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TMPH-03645
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Alpha-TCS Protein, Trichosanthes kirilowii, Recombinant (His)
rRNA N-glycosidase,EC:3.2.2.22,Ribosome-inactivatin...
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Trichosanthes kirilowii
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E. coli
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Inactivates eukaryotic 60S ribosomal subunits. Alpha-TCS Protein, Trichosanthes kirilowii, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 30.8 kDa and the accession number is P09989. |
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TMPH-00516
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StxA2 Protein, Enterobacteria phage 933W, Recombinant (E189K, His & Myc)
Verotoxin 2 subunit A,Verocytotoxin 2 subunit A,Shiga-like t...
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Enterobacteria phage 933W
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E. coli
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The A subunit is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits. After endocytosis, the A subunit is cleaved by furin in two fragments, A1 and A2: A1 is the catalytically active fragment, and A2 is essential for holotoxin assembly with the B subunits. |
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TMPH-00559
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30S ribosomal protein S15 Protein, E. coli, Recombinant (His)
Small ribosomal subunit protein uS15,30S ribosomal protein S...
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E. coli
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E. coli
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One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. Binds to its own mRNA, stabilizing it 5-UTR and preventing its translation.; In the E.coli 70S ribosome it has been modeled to contact the 23S rRNA of the 50S subunit forming part of bridge B4. In the two 3.5 A resolved ribosome structures there are minor differences between side-chain conformation... |
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TMPH-02999
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uL2 Protein, Mycobacterium tuberculosis, Recombinant (His)
rplB,50S ribosomal protein L2,Large ribosomal subunit protei...
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Mycobacterium tuberculosis
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E. coli
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One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. uL2 Protein, Mycobacterium tuberculosis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 34.7 kDa and the accession ... |
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TMPH-00561
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30S ribosomal protein S4 Protein, E. coli, Recombinant (His)
Small ribosomal subunit protein uS4,ramA,rpsD,30S ribosomal ...
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E. coli
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E. coli
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One of two assembly initiator proteins for the 30S subunit, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.; With S5 and S12 plays an important role in translational accuracy; many suppressors of streptomycin-dependent mutants of protein S12 are found in this protein, some but not all of which decrease translational accuracy (ram, ribosomal ambiguity mutations).; Plays a role in mRNA unwinding by the ribosome, possibly by forming part of a processivity c... |
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TMPJ-01357
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NHP2 Protein, Human, Recombinant (His)
NOLA2,Nucleolar protein family A member 2,snoRNP protein NHP...
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Human
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E. coli
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NHP2 belongs to the H/ACA snoRNPs gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been organized into 2 families: C/D and H/ACA. NHP2 forms a small ribonucleoprotein particle with GAR1 (NOLA1). NHP2 is involved in a variety of aspects of rRNA processing and modification. NHP2 localizes to the dense fibrillar component of the nucleolus and in nuclear Cajal bodies. NHP2 may also be required for correct processing or intranuclear trafficking of TERC... |
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TMPH-00562
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30S ribosomal protein S7 Protein, E. coli, Recombinant (His)
30S ribosomal protein S7,rpsG,Small ribosomal subunit protei...
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E. coli
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E. coli
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One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, where it has been shown to contact mRNA. Has been shown to contact tRNA in both the P and E sites; it probably blocks exit of the E site tRNA.; Protein S7 is also a translational repressor protein; it regulates the expression of the str operon members to different degrees by binding to its mRNA... |
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TMPH-00558
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30S ribosomal protein S11 Protein, E. coli, Recombinant (His)
rpsK,Small ribosomal subunit protein uS11
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E. coli
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E. coli
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Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome. |
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TMPH-03615
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Ribonuclease J Protein, Synechocystis sp., Recombinant (His & SUMO)
rnj,Ribonuclease J
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Synechocystis
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E. coli
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An RNase that has 5'-3' exonuclease and possibly endoonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. Ribonuclease J Protein, Synechocystis sp., Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 86.4 kDa and the accession number is P54123. |
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TMPH-00854
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RPS18 Protein, Human, Recombinant (GST)
Small ribosomal subunit protein uS13,Ke-3,40S ribosomal prot...
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Human
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E. coli
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Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA. RPS18 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 44.6 kDa and the accession number is P62269. |
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TMPY-02883
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C1D Protein, Human, Recombinant (GST)
SUNCOR,Rrp47,SUN-CoR,hC1D,C1D nuclear receptor corepressor,L...
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Human
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E. coli
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C1D nuclear receptor corepressor belongs to the C1D family. It is a DNA binding and apoptosis-inducing protein.C1D nuclear receptor corepressorinteracts with TSNAX and DNA-PKcs. It acts as a corepressor for the thyroid hormone receptor. It is thought that C1D nuclear receptor corepressor regulates TRAX/Translin complex formation. It is expressed in kidney, heart, brain, spleen, lung, testis, liver and small intestine. It plays a role in the recruitment of the RNA exosome complex to pre-rRNA to m... |
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TMPH-00015
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Abrin-d Protein, Abrus precatorius, Recombinant (His & Myc)
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Abrus precatorius
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E. coli
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The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA.; The B chain is a galactose-specific lectin that facilitates the binding of abrin to the cell membrane that precedes endocytosis. |
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TMPH-00014
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Abrin-c Protein, Abrus precatorius, Recombinant (His & Myc)
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Abrus precatorius
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E. coli
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The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. Abrin-a is more toxic than ricin.; The B chain is a galactose-specific lectin that facilitates the binding of abrin to the cell membrane that precedes endocytosis. Abrin-c Protein, Abrus precatorius, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight ... |
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TMPH-00012
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Abrin-a Protein, Abrus precatorius, Recombinant (E. coli, His)
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Abrus precatorius
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E. coli
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The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. Abrin-a is more toxic than ricin.; The B chain is a galactose-specific lectin that facilitates the binding of abrin to the cell membrane that precedes endocytosis. Abrin-a Protein, Abrus precatorius, Recombinant (E. coli, His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 33.6... |
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TMPJ-01395
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NIP7 Protein, Human, Recombinant (His)
KD93,NIP7,60S Ribosome Subunit Biogenesis Protein NIP7 Homol...
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Human
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E. coli
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60S Ribosome Subunit Biogenesis Protein NIP7 Homolog (NIP7) belongs to the NIP7 family. NIP7 contains one PUA domain, it is essential for the process of proper 27S pre-rRNA and 60S ribosome subunit assembly. NIP7 is a monomer form and interacts with NOL8 and SBDS, and may bind to RNA. In addition, NIP7 is one of the many trans-acting factors required for eukaryotic ribosome biogenesis, which interacts with nascent pre-ribosomal particles and dissociates as they complete maturation and are export... |
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TMPJ-01046
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RPS7 Protein, Human, Recombinant (His)
RPS7,40S ribosomal protein S7
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Human
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E. coli
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40S ribosomal protein S7(RPS7) belongs to the S7E family of ribosomal proteins. It is phosphorylated by NEK6 during post-translational modification. RPS7 is located in the cytoplasm, binds IPO9 with high affinity. it also can interacts with NEK6. As is required for rRNA maturation and typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. The unnormal expression of RPS7 may cause Diamond-Blackfan anemia 8. |
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TMPH-00013
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Abrin-a Protein, Abrus precatorius, Recombinant (Yeast, His)
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Abrus precatorius
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P. pastoris (Yeast)
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The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. Abrin-a is more toxic than ricin.; The B chain is a galactose-specific lectin that facilitates the binding of abrin to the cell membrane that precedes endocytosis. Abrin-a Protein, Abrus precatorius, Recombinant (Yeast, His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 30.1 kDa and the accession ... |
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TMPH-03707
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Viscumin Protein, Viscum album, Recombinant (His)
Beta-galactoside-specific lectin I,Viscumin,Beta-galactoside...
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Viscum album
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P. pastoris (Yeast)
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The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity). Inhibits growth of the human tumor cell line Molt4. Viscumin Protein, Viscum album, Recombinant (His) is expressed in yeast with N-6xHis tag. The predict... |
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TMPH-03193
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Alba Protein, Pyrococcus furiosus, Recombinant (His & SUMO)
DNA/RNA-binding protein Alba
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Pyrococcus furiosus
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E. coli
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Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes. Alba Protein, Pyrococcus furiosus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molec... |
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TMPH-00864
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RO60 Protein, Human, Recombinant (His)
TROVE domain family member 2,RNA-binding protein RO60,Sjoegr...
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Human
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E. coli
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RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation. Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammaotry cytokine secretion. Regulates the expression of Alu retroelements as well as inflammatory genes.; May play roles in cilia formation and/or maintenance. RO60 Protein, Human, Recombinant (His)... |
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TMPH-01247
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POLR3K Protein, Human, Recombinant (His)
RNA polymerase III subunit C11,POLR3K,RNA polymerase III 12....
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Human
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Baculovirus Insect Cells
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DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase I... |
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TMPY-04073
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MRPL44 Protein, Human, Recombinant (His)
mitochondrial ribosomal protein L44,COXPD16,L44MT,MRP-L44
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Human
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Baculovirus Insect Cells
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MRPL44 (Mitochondrial Ribosomal Protein L44) is a Protein Coding gene. MRPL44 encodes a protein in the large subunit of the mitochondrial ribosome and is suggested to locate near the tunnel exit of the yeast mitochondrial ribosome. It belongs to the mitochondrion-specific ribosomal protein mL44 subfamily. In the patient fibroblasts, decreased MRPL44 affected assembly of the large ribosomal subunit and stability of 16S rRNA leading to complex IV deficiency. It may have a function in the assembly/... |
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TMPH-01800
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Nucleolin Protein, Human, Recombinant (His)
NCL,Protein C23,Nucleolin
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Human
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P. pastoris (Yeast)
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Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Nucleolin Protein, ... |
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TMPH-02380
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RPB5 Protein, Kluyveromyces marxianus, Recombinant (His)
RPB5,DNA-directed RNA polymerases I, II, and III subunit RPA...
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Kluyveromyces marxianus
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E. coli
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DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol... |
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TMPJ-00947
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RPS19 Protein, Human, Recombinant
RPS19,40S Ribosomal Protein S19
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Human
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E. coli
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40S Ribosomal Protein S19 (RPS19) is a ribosomal protein that Belongs to the ribosomal protein S19e family. RPS19 is located in the nucleoli, and higher level expression is seen in colon carcinoma tissue than normal colon tissue. It required for pre-rRNA processing and maturation of 40S ribosomal subunits. RPS19 plays a role in many biological processes, such as endocrine pancreas development, erythrocyte differentiation, mRNA metabolic process. Defects in RPS19 are the cause of Diamond-Blackfan... |
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TMPY-02844
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EBP1 Protein, Human, Recombinant (His)
proliferation-associated 2G4,EBP1,p38-2G4,HG4-1
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Human
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E. coli
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EBP1, also known as PA2G4, is an RNA-binding protein that belongs to the peptidase M24 family. It can be detected n several cell lines tested, including primary and transformed cell lines. EBP1 also present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein is a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its int... |
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TMPH-02315
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XRCC5 Protein, Human, Recombinant (His & Myc)
ATP-dependent DNA helicase 2 subunit 2,XRCC5,Ku86,Nuclear fa...
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Human
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E. coli
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Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and bind... |
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TMPH-01246
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POLR3A Protein, Human, Recombinant (His)
RNA polymerase III subunit C160,RNA polymerase III 155 kDa s...
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Human
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E. coli
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DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft ... |
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TMPH-02314
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XRCC5 Protein, Human, Recombinant (His & MBP)
Nuclear factor IV,Lupus Ku autoantigen protein p86,ATP-depen...
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Human
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Baculovirus Insect Cells
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Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and bind... |
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