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Search Results for " proteasome substrates "

Targets Recommended: PARP Proteasome

3

抑制剂 & 化合物

6

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T6941	PI-1840 PI 1840	PARP; Proteasome	Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome; Ubiquitination
	PI-1840 是一种高效的、选择性的蛋白酶体chymotrypsin-like (CT-L)抑制剂，IC50=27nM。
T79742	CARM1 degrader-2	Histone Methyltransferase	Chromatin/Epigenetic
	CARM1 degrader-2 (compound 3e) 是一种效能高的CARM1降解剂，其DC50为8.8 nM。该化合物通过VHL途径及蛋白酶体作用实现CARM1的降解，进而抑制其底物PABP1和BAF155的甲基化作用，能够有效抑制乳腺癌细胞迁移。
T79741	CARM1 degrader-1	Histone Methyltransferase	Chromatin/Epigenetic
	CARM1 degrader-1 (compound 3b) 是一种针对co-activator associated argininemethyltransferase (CARM1) 的降解剂，其DC50为8.1 nM。它通过VHL和蛋白酶体依赖的途径降解CARM1，从而抑制了CARM1底物（例如PABP1和BAF155）的甲基化，进而抑制乳腺癌细胞的迁移。

化合物

Cat.No: T6941

Synonym: PI 1840

Target: PARP, Proteasome

CARM1 degrader-2

Cat.No: T79742

Target: Histone Methyltransferase

CARM1 degrader-1

Cat.No: T79741

Target: Histone Methyltransferase

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02300	RAD23A Protein, Human, Recombinant (His) UV excision repair protein RAD23 homolog A,RAD23A	Human	E. coli
	Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucle...
TMPJ-01386	STUB1 Protein, Human, Recombinant Carboxy Terminus of Hsp70-Interacting Protein,STIP1 Homology...	Human	E. coli
	E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain; lead to in client substrate ubiquitylation and degradation by the proteasome. CHIP targets misfolded chaperone substrates towards proteasomal degradation. CHIP mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation....
TMPH-01269	SMURF2 Protein, Human, Recombinant (His) SMAD ubiquitination regulatory factor 2,E3 ubiquitin-protein...	Human	E. coli
	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF-beta receptor ubiquitin-dependent degradation, thereby downregulating TGF-beta signaling. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with AIMP1. Also forms a stable com...
TMPH-02282	Ubiquilin-1 Protein, Human, Recombinant (His & Myc) Ubiquilin-1,UBQLN1,Protein linking IAP with cytoskeleton 1	Human	E. coli
	Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its in...
TMPH-01531	IKBKB Protein, Human, Recombinant (His) Serine/threonine protein kinase IKBKB,Nuclear factor NF-kapp...	Human	Baculovirus Insect Cells
	Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In tu...
TMPH-01532	IKBKB Protein, Human, Recombinant (E. coli, His) Nuclear factor NF-kappa-B inhibitor kinase beta,Serine/threo...	Human	E. coli
	Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In tu...

重组蛋白

RAD23A Protein, Human, Recombinant (His)

Cat.No: TMPH-02300

Species: Human

Expression System: E. coli

STUB1 Protein, Human, Recombinant

Cat.No: TMPJ-01386

Species: Human

Expression System: E. coli

SMURF2 Protein, Human, Recombinant (His)

Cat.No: TMPH-01269

Species: Human

Expression System: E. coli

Ubiquilin-1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02282

Species: Human

Expression System: E. coli

IKBKB Protein, Human, Recombinant (His)

Cat.No: TMPH-01531

Species: Human

Expression System: Baculovirus Insect Cells

IKBKB Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-01532

Species: Human

Expression System: E. coli

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