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Search Results for " prostaglandin e1 "

Targets Recommended: Others

27

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T36770	11-deoxy Prostaglandin E1 11-deoxy Prostaglandin E1	Others	Others
	11-deoxy Prostaglandin E1 是前列腺素 E1类似物，具有支气管扩张活性，可抑制组胺诱导的支气管收缩，引起离体豚鼠的气管条松弛。
T36726	6-keto Prostaglandin E1 6-keto Prostaglandin E1	Others	Others
	6-keto Prostaglandin E1 是 PGE1 的生物活性衍生物，在抗血小板聚集和解聚作用方面发挥作用。
T36159	8-iso Prostaglandin E1 8-iso Prostaglandin E1	Others	Others
	8-iso Prostaglandin E1 能引起犬肺静脉中的痉挛，还能够起到血管舒张作用。
T36775	13,14-dihydro Prostaglandin E1 13,14-dihydro Prostaglandin E1	Others	Others
	13,14-dihydro Prostaglandin E1 (13,14-dihydro PGE1) is a biologically active metabolite of PGE1 with comparable potency to the parent compound. It is an inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC50 values of 31 and 21 nM, respectively. 13,14-dihydro PGE1 is a slightly more potent inhibitor of ADP-induced human platelet aggregation than PGE1 which has an IC50 value of 40 nM. Also, 13,14-dihydro PGE1 was shown to activate adenylate cyclase in NCB-20 hyb...
T36214	16,16-dimethyl Prostaglandin E1 16,16-dimethyl Prostaglandin E1	Others	Others
	16,16-dimethyl Prostaglandin E1 是 PGE1 (T1626) 类似物，可诱导支气管收缩和血管平滑肌收缩，并抑制吲哚美辛诱导的细胞伸长。
T36219	1a,1b-dihomo Prostaglandin E1 1a,1b-dihomo Prostaglandin E1	Others	Others
	1a,1b-dihomo Prostaglandin E1 是一类前列腺素化合物。
T84592	Prostaglandin E1 ethanolamide Alprostadil Ethanolamide	Others	Others
	Prostaglandin E1 ethanolamide，前列腺素E1 (PGE1) 的类似物，可能有效抑制GLI2诱导的靶基因表达（包括Gli1和Ptch1）和肿瘤生长。
T85025	tetranor-Prostaglandin E1 Tetranor PGE1,7α,11-Dihydroxy-5-ketotetranorprost-9-enoic Acid,Tetranorprostaglandin E1	Others	Others
	Tetranor-Prostaglandin E1 (tetranor-PGE1), a metabolite of PGE1 and PGE2, undergoes formation through β-oxidation.
T29907	Alprostadil sodium PGE1 sodium salt,Prostaglandin E1 sodium	Others	Others
	Alprostadil sodium 是一种前列腺素受体配体，对小鼠 EP1、EP2、EP3、EP4和 IP 的 Ki 值分别为 36、10、1.1、2.1 和 33 nM。它诱导血管舒张并抑制血小板聚集，可作为血管扩张剂用于外周血管疾病的研究。
T37778	19(R)-hydroxy Prostaglandin E1 19(R)-hydroxy Prostaglandin E1	Others	Others
	19(R)-hydroxy Prostaglandin E1 是 EP1 和 EP3 受体亚型的激动剂，并对平滑肌表现出收缩活性，也是灵长类动物精液中的主要前列腺素。
T29908	Alprostadil ethyl ester Prostaglandin E1 ethyl ester,PGE1 ethyl ester	Others	Others
	Alprostadil ethyl ester is a biochemical used in the treatment of scleroderma.
T84595	2,3-dinor Prostaglandin E1 2,3-dinor PGE1	Others	Others
	Prostaglandin E1 (PGE1), though not predominantly found in nature, plays a significant role in clinical treatments, addressing conditions such as peripheral occlusive vascular disease, erectile dysfunction, and neonatal cardiology issues. The metabolism of PGE1 primarily begins with the oxidation at C-15, producing 13,14-dihydro-15-keto PGE1 as its major metabolite. Alternatively, inhibiting this pathway or overwhelming it with too much PGE1 could potentially enhance the production of 2,3-dinor ...
T25362	Ecraprost AS013,Circulase,AS 013,AS-013,Lipo-pro-prostaglandin E1	Others	Others
	Ecraprost is used as a prodrug of prostaglandin E1.
T41323	Dihomo-γ-Linolenic acid methyl ester	Others	Others
	Dihomo-γ-Linolenic acid methyl ester 是 Dihomo-γ-Linolenic acid 的甲酯形式，Dihomo-γ-Linolenic acid 具有抗炎和抗增殖作用。
T36147	13,14-dihydro-15-keto Prostaglandin E1 13,14-dihydro-15-keto Prostaglandin E1	Others	Others
	13,14-dihydro-15-keto Prostaglandin E1 可抑制 ADP 诱导的人离体富血小板血浆中的血小板聚集（IC50=14.8 μg/mL），也是 PGE1 代谢物。
T84527	13,14-dihydro-15(R)-Prostaglandin E1 13,14-dihydro-15(R)-PGE1	Others	Others
	13,14-dihydro-15(R)-Prostaglandin E1 (13,14-dihydro-15(R)-PGE1)为13,14-二氢-PGE1的同分异构体，特点在于其C-15位的羟基呈R构型，非自然形态。
T84513	13,14-dihydro-16,16-difluoro Prostaglandin E1 15-hydroxy Lubiprostone	Others	Others
	Prostaglandin E1 (PGE1), synthesized through cyclooxygenase-mediated metabolism of dihomo-γ-linolenic acid (DGLA), functions by inhibiting platelet aggregation (IC50= 40 nM) and enhancing vasodilation. Its analog, 13,14-dihydro-16,16-difluoro PGE1, and the metabolite, 13,14-dihydro PGE1, both retain similar anti-aggregatory properties to the original compound. The inclusion of two electron-withdrawing fluorine atoms in 13,14-dihydro-16,16-difluoro PGE1 is believed to increase molecular stability...
T84528	13,14-dihydro-19(R)-hydroxy Prostaglandin E1 19(R)-hydroxy PGE0	Others	Others
	13,14-Dihydro-19(R)-hydroxy Prostaglandin E1 (13,14-dihydro-19(R)-hydroxy PGE1) is posited as a theoretical metabolite resulting from the action of ω-1 hydroxylase on 13,14-dihydro PGE1. Its biosynthesis and biological activity remain unreported in scientific literature.
T20710	Ornoprostil OU-1308,OU 1308,OU1308,Ronoprost	Others	Others
	Ornoprostil, a prostaglandin E1 analogue, acts as a mucosal protectant.
T84560	Prostaglandin A1 PGA1	Others	Others
	Prostaglandin A1，Prostaglandin E1的脱水衍生物，具有抑制肿瘤生长、炎症、病毒复制、血小板聚集以及神经毒素诱导的神经元凋亡(apoptosis)的作用。
T20855	Gemeprost SC-37681,SC 37681,Carprost,Gemeprostum,Cervagem,Preglandin	Others	Others
	Gemeprost, an analog of prostaglandin E1, is used for the treatment of obstetric bleeding. It is used to terminate pregnancy up to 24 weeks gestation together with mifepristone.
T26090	Rioprostil TR 4698,TR4698,Rioprostilum,TR-4698	Others	Others
	Rioprostil is a methyl prostaglandin E1 analog that decreases gastric acid secretion and enhances the gastric mucus-bicarbonate barrier. It is effective in the treatment of gastric ulcers and gives significant protection against NSAID-induced gastric muco
T73346	SC 34301 Enisoprost	Others	Others
	SC 34301 (Enisoprost)为有效的口服活性PGE1类似物，显著降低细菌移位并提升烧伤小鼠存活率。
T84643	Dihomo-γ-Linolenic Acid ethyl ester ethyl 20:3ω6	Others	Others
	Ethyl dihomo-γ-linolenic acid ethyl ester (ethyl DGLA), an ω-6 fatty acid intermediate ester form, elevates prostaglandin E1(PGE1) and PGE2 secretion in rabbit renal papilla when administered dietarily at a dosage of 1 g/kg per day for 25 days. Additionally, this dosage of ethyl DGLA increases triglyceride levels and enhances the proportion of 20:3ω6 and 20:4ω6 phospholipids in the renal medulla of rabbits. Ethyl DGLA formulations have been employed in managing eczema and inflammatory disorders.
T84995	1-Palmitoyl-d9-2-hydroxy-sn-glycero-3-PA 1-Hexadecanoyl-d9-2-hydroxy-sn-glycero-3-phosphate	Others	Others
	1-Palmitoyl-d9-2-hydroxy-sn-glycero-3-PA (1-palmitoyl-d9LPA) serves as an internal standard for the quantification of 1-palmitoyl LPA using GC- or LC-MS. This compound, an analog of LPA with palmitic acid at the sn-1 position, activates reporter gene expression in PC12 cells fitted with human lysophosphatidic acid receptor 4 (LPA4) at 0.01 to 10 µM concentrations. Additionally, 1-palmitoyl LPA prompts aggregation in isolated human platelets within the 12-300 µM range, a process reversible by pro...
T84609	(±)5(6)-DiHET (±)5,6-DiHETrE	Others	Others
	5(6)-DiHET is a racemic compound synthesized through the action of epoxide hydrolases on 5(6)-EET, encompassing both enantiomeric forms. It serves as a quantitative marker for 5(6)-EET, facilitating its measurement by utilizing the compound's conversion to 5(6)-δ-lactone in solution. Additionally, 5(6)-DiHET activates large-conductance calcium-activated potassium (KCa1.1/BK) channels in rat small coronary artery smooth muscle cells, supporting its biological significance in vascular regulation. ...
T83807	Rp-Adenosine-5'-O-(1-thiotriphosphate) sodium Rp-ATP-α-S	Others	Others
	Rp-Adenosine-5'-O-(1-thiotriphosphate)（Rp-ATP-α-S）是一种含硫核苷酸衍生物ATP-α-S的异构体，同时也是嘌呤P2Y1受体的激动剂。在表达人类P2Y1受体的HEK293细胞中，Rp-ATP-α-S能增加钙的动员（EC50 = 75 nM）。该化合物与洗涤的人类孤立血小板结合（Ki = 156 nM），抑制由ADP引发的人类富血小板血浆（PRP）的聚集（pA2 = 4.74），并且能够抑制前列腺素E1（PGE1）在人类孤立PRP中引发的cAMP产生（pA2 = 5.26）。同时，Rp-ATP-α-S还能引起用氨基甲酰胆碱预先缩紧的豚鼠结肠条带的松弛（EC50 = 56 nM）。此外，Rp-ATP-α-S已经被用于合成被细菌核糖开关识别的环状二核苷酸。

化合物

11-deoxy Prostaglandin E1

Cat.No: T36770

Synonym: 11-deoxy Prostaglandin E1

Target: Others

6-keto Prostaglandin E1

Cat.No: T36726

Synonym: 6-keto Prostaglandin E1

Target: Others

8-iso Prostaglandin E1

Cat.No: T36159

Synonym: 8-iso Prostaglandin E1

Target: Others

13,14-dihydro Prostaglandin E1

Cat.No: T36775

Synonym: 13,14-dihydro Prostaglandin E1

Target: Others

16,16-dimethyl Prostaglandin E1

Cat.No: T36214

Synonym: 16,16-dimethyl Prostaglandin E1

Target: Others

1a,1b-dihomo Prostaglandin E1

Cat.No: T36219

Synonym: 1a,1b-dihomo Prostaglandin E1

Target: Others

Prostaglandin E1 ethanolamide

Cat.No: T84592

Synonym: Alprostadil Ethanolamide

Target: Others

tetranor-Prostaglandin E1

Cat.No: T85025

Synonym: Tetranor PGE1,7α,11-Dihydroxy-5-ketotetranorprost-9-enoic Acid,Tetranorprostaglandin E1

Target: Others

Alprostadil sodium

Cat.No: T29907

Synonym: PGE1 sodium salt,Prostaglandin E1 sodium

Target: Others

19(R)-hydroxy Prostaglandin E1

Cat.No: T37778

Synonym: 19(R)-hydroxy Prostaglandin E1

Target: Others

Alprostadil ethyl ester

Cat.No: T29908

Synonym: Prostaglandin E1 ethyl ester,PGE1 ethyl ester

Target: Others

2,3-dinor Prostaglandin E1

Cat.No: T84595

Synonym: 2,3-dinor PGE1

Target: Others

Cat.No: T25362

Synonym: AS013,Circulase,AS 013,AS-013,Lipo-pro-prostaglandin E1

Target: Others

Dihomo-γ-Linolenic acid methyl ester

Cat.No: T41323

Target: Others

13,14-dihydro-15-keto Prostaglandin E1

Cat.No: T36147

Synonym: 13,14-dihydro-15-keto Prostaglandin E1

Target: Others

13,14-dihydro-15(R)-Prostaglandin E1

Cat.No: T84527

Synonym: 13,14-dihydro-15(R)-PGE1

Target: Others

13,14-dihydro-16,16-difluoro Prostaglandin E1

Cat.No: T84513

Synonym: 15-hydroxy Lubiprostone

Target: Others

13,14-dihydro-19(R)-hydroxy Prostaglandin E1

Cat.No: T84528

Synonym: 19(R)-hydroxy PGE0

Target: Others

Cat.No: T20710

Synonym: OU-1308,OU 1308,OU1308,Ronoprost

Target: Others

Prostaglandin A1

Cat.No: T84560

Synonym: PGA1

Target: Others

Cat.No: T20855

Synonym: SC-37681,SC 37681,Carprost,Gemeprostum,Cervagem,Preglandin

Target: Others

Cat.No: T26090

Synonym: TR 4698,TR4698,Rioprostilum,TR-4698

Target: Others

Cat.No: T73346

Synonym: Enisoprost

Target: Others

Dihomo-γ-Linolenic Acid ethyl ester

Cat.No: T84643

Synonym: ethyl 20:3ω6

Target: Others

1-Palmitoyl-d9-2-hydroxy-sn-glycero-3-PA

Cat.No: T84995

Synonym: 1-Hexadecanoyl-d9-2-hydroxy-sn-glycero-3-phosphate

Target: Others

Cat.No: T84609

Synonym: (±)5,6-DiHETrE

Target: Others

Rp-Adenosine-5'-O-(1-thiotriphosphate) sodium

Cat.No: T83807

Synonym: Rp-ATP-α-S

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T1626	Prostaglandin E1 前列地尔,PGE1,列腺素E1,Alprostadil	Endogenous Metabolite; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism
	Prostaglandin E1 (Alprostadil) 是一种前列腺素受体配体，对小鼠 EP1、EP2、EP3、EP4和 IP 的 Ki 值分别为 36、10、1.1、2.1 和 33 nM。它诱导血管舒张并抑制血小板聚集，可作为血管扩张剂用于外周血管疾病的研究。

天然产物

Prostaglandin E1

Cat.No: T1626

Synonym: 前列地尔,PGE1,列腺素E1,Alprostadil

Target: Endogenous Metabolite, Prostaglandin Receptor

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