首页工具

登录

搜索结果

Search Results for " poly adp ribose polymerase "

Targets Recommended: PARP

84

抑制剂 & 化合物

17

天然产物

13

重组蛋白

1

同位素标记化合物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T22749	DR2313 DR 2313	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	DR2313 是一种选择性，竞争性的和可透过血脑屏障的PARP 抑制剂，对PARP-1和PARP-2的IC50值分别为 0.20 和 0.24 μM。它在体内外均有对缺血性损伤的神经保护作用。
T50098	TIQ-A	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	TIQ-A 是一种 PARP1 抑制剂，通过碱基切除修复途径参与 DNA 单链断裂修复。 PARP1 由 DNA 损伤触发，其过度激活已被认为是许多病理状况的致病因素，包括缺血和再灌注损伤、哮喘相关炎症和动脉粥样硬化形成。
T16761	RK-287107	Others; PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair; Others
	RK-287107 是一种有效且特异性的 tankyrase 抑制剂，可阻断结直肠癌细胞生长，对 tankyrase-1和 tankyrase-2的 IC50分别为 14.3 和 10.6 nM。
T6181	UPF 1069	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	UPF 1069 是一种特异性PARP 抑制剂，对 PARP-1 和 PARP-2 的IC50值分别为 8 和 0.3 μM。
T6197	PJ34	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	PJ34 是一种PARP1/2的特异性有效抑制剂，IC50分别为 110 nM 和 86 nM。
T6768	AZ6102	PARP; Wnt/beta-catenin	Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Stem Cells
	AZ6102 是TNKS1和TNKS2双重抑制剂，IC50值分别为 3 和 1 nM，选择性是对 PARP 家族其他蛋白的 100 多倍，对 PARP1、PARP2 和 PARP6 的IC50值分别为 2.0、0.5 和大于 3 μM。
T6578	ME0328	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	ME0328 是一种有效的选择性 PARP 抑制剂，对 PARP3 的 IC50 为 0.89 μM。
T2484	AZD-2461	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	AZD-2461 是一种 PARP 抑制剂，可抑制 PARP1、PARP2 和 PARP3 的活性，IC50值分别为 5、2 和 200 nM。
T3168	MN-64 MN64	Others; PARP; Wnt/beta-catenin	Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Others; Stem Cells
	MN-64 是一种有效的tankyrase 1抑制剂，对TNKS1、TNKS2、ARTD1 和 ARTD2 的IC50值分别为 6、72、19.1 和 39.4 μM。
T21524	4-amino-1,8-Naphthalimide	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	4-amino-1,8-Naphthalimide 是PARP 抑制剂，可增强癌细胞对 γ 辐射诱导的细胞毒性的敏感度。
T9165	AZD5305	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	AZD5305 是一种强效、选择性和口服活性 PARP 抑制剂，可用于肿瘤异体移植模型研究。
T15639	K-756	PARP; Wnt/beta-catenin	Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Stem Cells
	K-756 是一种直接的 tankyrase(TNKS) 选择性抑制剂，对 TNKS1和 TNKS2的 ADP-核糖基化活性有抑制作用，IC50分别为 31 和 36 nM。
T6842	G007-LK	PARP; Wnt/beta-catenin	Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Stem Cells
	G007-LK 是 TNKS1 和 TNKS2 的选择性抑制剂，IC50 分别为 46 nM 和 25 nM。
T8964	G244-LM	Others; PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair; Others
	G244-LM 是一种特异性有效的tankyrase 1/2抑制剂，可抑制Wnt 信号传导。
T1807	JW 55 JW55	PARP; Wnt/beta-catenin	Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Stem Cells
	JW 55 (JW55) 是一种有效且选择性的 β-catenin 信号通路抑制剂，通过抑制 tankyrase 1 和 tankyrase 2 (TNKS1/2) 的 PARP 结构域起作用。
T4471	E7449 Stenoparib,UNII-9X5A2QIA7C	Others; PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair; Others
	E7449 (UNII-9X5A2QIA7C) 是一种有效的 PARP1 和 PARP2 抑制剂，也抑制 TNKS1 和 TNKS2，使用 32P-NAD+ 作为底物，对 PARP1、PARP2、TNKS1 和 TNKS2 的 IC50 分别为 2.0、1.0、约 50 和约 50 nM。
T7042	1,5-Isoquinolinediol	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	1,5-Isoquinolinediol 是一种多聚（ADP-核糖）合成酶抑制剂，对PARP1的IC50值为 0.39 µM。它用于研究 PARP1 在 DNA 修复和氧化应激诱导的细胞死亡中的作用。
T3062	WIKI4	PARP; Wnt/beta-catenin	Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Stem Cells
	WIKI4 是tankyrase 有效抑制剂，其对TNKS2的IC50值为 26 nM。它有效抑制Wnt/β-catenin 信号传导，其EC50值为 75 nM。它通过抑制TNKS2的酶活性来介导其对Wnt/β-catenin 信号传导的影响。它对 SCLC 细胞具有细胞毒性，其IC50值为 0.02 μM。
T22264	AZ9482	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	AZ9482 是一种选择性 PARP1/2/6的三重抑制剂，IC50值分别为 1 、1 和640 nM。
T4472	NMS-P118	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	NMS-P118是可口服的高选择性PARP-1抑制剂，用于癌症治疗，在HeLa 细胞中的IC50值为0.04 μM。
T5058	Pamiparib BGB-290	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Pamiparib (BGB-290) 是一种具有口服活性、强效、高选择性的 PARP 抑制剂，对PARP1和PARP2的IC50值分别为 0.9 nM 和 0.5 nM。它具有强大的 PARP 捕获能力，具有穿透大脑的能力，可用于研究癌症。
T6339	AG14361 AG 14361,AG-14361	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	AG14361 是一种 PARP-1抑制剂，Ki 值小于 5 nM，在通透的 SW620 细胞和完整的 SW620 细胞中，抑制 PARP-1的活性，IC50值分别为 29 和 14 nM。
T9593	Senaparib IMP4297	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Senaparib (IMP4297) 是一种选择性和口服有效的PARP1/2抑制剂，具有强效的抗肿瘤活性。
T5399	GeA-69	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	GeA-69 是一种选择性变构 PARP14 大结构域 2 (MD2) 抑制剂，Kd 值为 2.1 µM。
T22414	RBN012759	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	RBN012759 是选择性和具有口服活性的 PARP14抑制剂，IC50值小于3 nM，可降低促肿瘤巨噬细胞功能并在肿瘤外植体中引发炎症反应，比对 monoPARPs 的选择性高 300 倍，比对 polyPARPs 的选择性高 1000 倍。
T9430	Venadaparib NOV140101,IDX-1197	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Venadaparib (NOV140101) 是一种选择性和具有口服活性的 PARP 抑制剂，对 PARP1和 PARP2的 IC50分别为 1.4 和 1.0 nM。它可防止 DNA 单链断裂 (SSB) 的修复，可研究实体瘤。
T7896	BYK204165 RT-017290	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	BYK204165 (RT-017290) 是一种选择性PARP1抑制剂，对重组人 PARP1的pIC50值为 7.35，pKi 值为7.05。它对鼠 PARP-2的pIC50值为 5.38 ，其对 PARP1 的选择性比对 PARP2 高 100 倍。
T3649	BGP-15 BGP15,BGP-15 2HCl	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	BGP-15 (BGP-15 2HCl) 是一种PARP 抑制剂，IC50和Ki 值分别为 120 和 57 μM，在缺血再灌注损伤后具有保护作用。
T12695	RBN-2397	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	RBN-2397 是一种有效的、选择性的、具有口服活性的跨物种 NAD+ 竞争性 PARP7 抑制剂，IC50 小于 3 nM。它选择性结合 PARP7 ，Kd 为0.001 μM，可恢复干扰素 I 型信号转导，有用于晚期或转移性实体肿瘤的研究潜力。
T9497	Niraparib tosylate monohyrate	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Niraparib tosylate monohyrate 也称为 MK-4827，是一种聚 (ADP-核糖) 聚合酶 (PARP) 抑制剂，具有潜在的抗肿瘤活性。 MK4827 抑制 PARP 活性，增强 DNA 链断裂的积累，促进基因组不稳定性和细胞凋亡。 PARP 蛋白家族通过碱基切除修复 (BER) 途径检测和修复单链 DNA 断裂。
T1878	XAV-939 XAV939,NVP-XAV939	PARP; Wnt/beta-catenin	Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Stem Cells
	XAV-939 (NVP-XAV939) 是一种 Tankyrase (TNKS) 抑制剂，抑制 TNKS1 和 TNKS2 (IC50=11/4 nM)。XAV-939 可以选择性抑制 Wnt/β-catenin 介导的转录。
T2591	Veliparib ABT-888,NSC 737664,维利帕尼	PARP; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Veliparib (ABT-888) 是一种可口服的 PARP 抑制剂，抑制PARP1和PARP2的Ki 分别为 5.2 和 2.9 nM。它增强细胞凋亡和自噬。
T6912	NU1025 NSC 696807	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	NU1025 (NSC-696807) 是一种PARP 的有效抑制剂，IC50为 400 nM，Ki 为 48 nM。它可增强电离辐射和抗癌药物的细胞毒性，有抗癌和神经保护的作用。
T2124	PJ34 hydrochloride PJ34 HCl	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	PJ34 hydrochloride (PJ34 HCl) 是一种 PARP1/2的特异性有效抑制剂，IC50值分别为 110 nM 和 86 nM。
T3231	Niraparib 尼拉帕尼,MK-4827	Apoptosis; Others; PARP	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Others
	Niraparib (MK-4827) 是一种 PARP 抑制剂，可以抑制 PARP1 和 PARP2 (IC50=3.8/2.1 nM)，具有选择性。Niraparib 具有抗肿瘤活性，可以抑制 DNA 损伤修复、诱导细胞凋亡。
T7439	3-Methoxybenzamide 3-MBA,3-甲氧基苯甲酰胺	PARP; Antibacterial; Transferase	Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	3-Methoxybenzamide (3-MBA) 是一种多聚 ADP-核糖合成酶的竞争性抑制剂，可抑制枯草芽孢杆菌的细胞分裂，诱导细胞凋亡。它可促进蓝薯植株的生长、微瘤化和转化效率。
T6366	A-966492 2-[2-氟-4-[(2S)-2-吡咯烷基]苯基]-1H-苯并咪唑-7-甲酰胺	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	A966492 是一种新型有效的抑制剂，对 PARP1 和 PARP2 的 Ki 分别为 1 nM 和 1.5 nM。
T9024	OUL35 NSC39047	Others; PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair; Others
	OUL35 (NSC-39047) 是一种选择性 PARP-10 抑制剂和小分子 ARTD10 抑制剂，其 IC50值为 329 nM。
T3261	NVP-TNKS656 TNKS656	Apoptosis; PARP; Wnt/beta-catenin	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Stem Cells
	NVP-TNKS656 (TNKS656) 是一种可口服的选择性TNKS2抑制剂，IC50值为 6 nM。
T8806	Fluzoparib HS10160,SHR3162,氟唑帕利	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Fluzoparib (SHR3162) 是口服活性 PARP1抑制剂，IC50为1.46±0.72 nM，在体内具有良好的药代动力学特性，具有抗肿瘤活性，可用于癌症研究。它选择性地抑制同源重组修复(HR) 缺陷细胞的增殖，并使 HR 缺陷细胞对细胞毒性药物敏感。
T12064	Niraparib (R-enantiomer) MK 4827 (R-enantiomer),Niraparib R-enantiomer	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Niraparib R-enantiomer (MK 4827 R-enantiomer) 是一种 PARP1抑制剂，IC50为 2.4 nM。
T16807	Rucaparib monocamsylate 瑞卡帕布樟脑磺酸盐,Rucaparib Camsylate	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Rucaparib monocamsylate (Rucaparib Camsylate) 是一种口服有效的 PARP 蛋白抑制剂，对 PARP-1 的Ki 为 1.4 nM。它是六磷酸己糖脱氢酶 (H6PD) 抑制剂，有用于去势抵抗性前列腺癌 (CRPC) 的研究潜力。
T6329	3-Aminobenzamide 3-AB,INO1001,INO-1001,3-ABA,PARP-IN-1,INO 1001	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	3-Aminobenzamide (PARP-IN-1) 是一种有效的 PARP 抑制剂，在 CHO 细胞中，对 PARP 的 IC50值约为 50 nM。它是再灌注过程中氧化剂诱导的肌细胞功能障碍的介质。
T60019	VPC-70063 Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-	Apoptosis; PARP; c-Myc	Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair
	VPC-70063 (Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-) 是 c-Myc-MAX 的抑制剂。 VPC-70063 的 Myc-Max 转录活性抑制率为 106%，IC50 为 8.9 μM，Myc-Max/UBE2C 下游通路抑制率为 94%。 VPC-70063 可用于抗癌研究。
T3015	Olaparib AZD2281,奥拉帕尼,KU0059436	Mitophagy; PARP; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Olaparib (KU0059436) 是 PARP1/PARP2 的小分子抑制剂 (IC50=5/1 nM)，对 PARP tankyrase-1 的抑制活性较弱 (IC50=1.5 μM)，具有选择性和口服活性。Olaparib 具有自噬和线粒体自噬激活活性。
T2105	Veliparib dihydrochloride 维利帕尼二盐酸盐,ABT-888 dihydrochloride	PARP; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Veliparib dihydrochloride (ABT-888 dihydrochloride) 是一种PARP1和PARP2抑制剂，Ki 分别为5.2 nM 和2.9 nM。
T9891	PARP1-IN-8 N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	PARP1-IN-8 (N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide) 是PARP1的有效抑制剂（IC50 = 97 nM）。
T6253	Talazoparib LT-673,BMN-673,他拉唑帕利	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Talazoparib (LT-673) 是一种 PARP 抑制剂，可以抑制 PARP 1和 PARP 2 (Ki=1.2/0.87 nM)，具有口服活性。Talazoparib 具有抗肿瘤活性，可以通过阻断 PARP 酶活性以及将 PARP 捕获在 DNA 损伤位点上来诱导肿瘤细胞死亡。
T6941	PI-1840 PI 1840	PARP; Proteasome	Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome; Ubiquitination
	PI-1840 是一种高效的、选择性的蛋白酶体chymotrypsin-like (CT-L)抑制剂，IC50=27nM。
T6224	Iniparib NSC-746045,IND-71677,3-硝基-4-碘苯甲酰胺,BSI-201	PARP; Influenza Virus	Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology
	Iniparib (BSI-201) 是一种不可逆的 PARP1抑制剂，在三阴性乳腺 Y 中表现出效力。

化合物

Cat.No: T22749

Synonym: DR 2313

Target: PARP

Cat.No: T50098

Target: PARP

Cat.No: T16761

Target: Others, PARP

Cat.No: T6181

Target: PARP

Cat.No: T6197

Target: PARP

Cat.No: T6768

Target: PARP, Wnt/beta-catenin

Cat.No: T6578

Target: PARP

Cat.No: T2484

Target: PARP

Cat.No: T3168

Synonym: MN64

Target: Others, PARP, Wnt/beta-catenin

4-amino-1,8-Naphthalimide

Cat.No: T21524

Target: PARP

Cat.No: T9165

Target: PARP

Cat.No: T15639

Target: PARP, Wnt/beta-catenin

Cat.No: T6842

Target: PARP, Wnt/beta-catenin

Cat.No: T8964

Target: Others, PARP

Cat.No: T1807

Synonym: JW55

Target: PARP, Wnt/beta-catenin

Cat.No: T4471

Synonym: Stenoparib,UNII-9X5A2QIA7C

Target: Others, PARP

1,5-Isoquinolinediol

Cat.No: T7042

Target: PARP

Cat.No: T3062

Target: PARP, Wnt/beta-catenin

Cat.No: T22264

Target: PARP

Cat.No: T4472

Target: PARP

Cat.No: T5058

Synonym: BGB-290

Target: PARP

Cat.No: T6339

Synonym: AG 14361,AG-14361

Target: PARP

Cat.No: T9593

Synonym: IMP4297

Target: PARP

Cat.No: T5399

Target: PARP

Cat.No: T22414

Target: PARP

Cat.No: T9430

Synonym: NOV140101,IDX-1197

Target: PARP

Cat.No: T7896

Synonym: RT-017290

Target: PARP

Cat.No: T3649

Synonym: BGP15,BGP-15 2HCl

Target: PARP

Cat.No: T12695

Target: PARP

Niraparib tosylate monohyrate

Cat.No: T9497

Target: PARP

Cat.No: T1878

Synonym: XAV939,NVP-XAV939

Target: PARP, Wnt/beta-catenin

Cat.No: T2591

Synonym: ABT-888,NSC 737664,维利帕尼

Target: PARP, Autophagy

Cat.No: T6912

Synonym: NSC 696807

Target: PARP

PJ34 hydrochloride

Cat.No: T2124

Synonym: PJ34 HCl

Target: PARP

Cat.No: T3231

Synonym: 尼拉帕尼,MK-4827

Target: Apoptosis, Others, PARP

3-Methoxybenzamide

Cat.No: T7439

Synonym: 3-MBA,3-甲氧基苯甲酰胺

Target: PARP, Antibacterial, Transferase

Cat.No: T6366

Synonym: 2-[2-氟-4-[(2S)-2-吡咯烷基]苯基]-1H-苯并咪唑-7-甲酰胺

Target: PARP

Cat.No: T9024

Synonym: NSC39047

Target: Others, PARP

Cat.No: T3261

Synonym: TNKS656

Target: Apoptosis, PARP, Wnt/beta-catenin

Cat.No: T8806

Synonym: HS10160,SHR3162,氟唑帕利

Target: PARP

Niraparib (R-enantiomer)

Cat.No: T12064

Synonym: MK 4827 (R-enantiomer),Niraparib R-enantiomer

Target: PARP

Rucaparib monocamsylate

Cat.No: T16807

Synonym: 瑞卡帕布樟脑磺酸盐,Rucaparib Camsylate

Target: PARP

3-Aminobenzamide

Cat.No: T6329

Synonym: 3-AB,INO1001,INO-1001,3-ABA,PARP-IN-1,INO 1001

Target: PARP

Cat.No: T60019

Synonym: Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-

Target: Apoptosis, PARP, c-Myc

Cat.No: T3015

Synonym: AZD2281,奥拉帕尼,KU0059436

Target: Mitophagy, PARP, Autophagy

Veliparib dihydrochloride

Cat.No: T2105

Synonym: 维利帕尼二盐酸盐,ABT-888 dihydrochloride

Target: PARP, Autophagy

Cat.No: T9891

Synonym: N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide

Target: PARP

Cat.No: T6253

Synonym: LT-673,BMN-673,他拉唑帕利

Target: PARP

Cat.No: T6941

Synonym: PI 1840

Target: PARP, Proteasome

Cat.No: T6224

Synonym: NSC-746045,IND-71677,3-硝基-4-碘苯甲酰胺,BSI-201

Target: PARP, Influenza Virus

Cat. No.	Product Name	Target	Signaling Pathways
T8184	Fucosterol 岩皂甾醇,岩藻甾醇	PARP; Endogenous Metabolite; PPAR	Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	Fucosterol 是从藻类、海藻或硅藻中分离的一种甾醇，具有抗氧化、抗脂肪、降低血液胆固醇、抗糖尿病和抗癌活性。它通过抑制 PPARα和C/EBPα的表达调控脂肪生成，可用于抗肥胖试剂开发研究。
T7443	4'-Methoxychalcone 4'-甲氧基查耳酮,4'-甲氧基查尔酮	PARP; PPAR	Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	4'-Methoxychalcone 通过PPARγ活化调节脂肪细胞分化，并调节参与胰岛素敏感性的脂肪组织中各种脂肪因子的表达和分泌，具抗肿瘤和抗炎活性。
T8150	Nudifloramide 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide,1-甲基-6-氧代吡啶-3-甲酰胺	PARP; Endogenous Metabolite	Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	Nudifloramide 是烟酰胺-腺嘌呤二核苷酸 (NAD) 降解的一种最终产物，可显著抑制PARP-1活性。
T5S2358	Dehydrocorydaline Dehydrocorydalin,脱氢紫堇碱,13-Methylpalmatine	BCL; PARP; p38 MAPK; Caspase; Parasite; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Proteases/Proteasome
	Dehydrocorydaline (13-Methylpalmatine) 是一种生物碱。它调节Bax，Bcl-2蛋白表达，激活caspase-7，caspase-8，并使PARP 失活。它能增强p38 MAPK 活化，具有抗炎、抗癌等功效。它具有强大的抗疟疾作用，并具低细胞毒性。
T6780	Benzamide Amid kyseliny benzoove,苯甲酰胺,Phenylcarboxyamide,Benzoylamide	PARP; Endogenous Metabolite	Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	Benzamide (Amid kyseliny benzoove) 是聚(ADP-核糖)聚合酶的抑制剂，是苯甲酸的衍生物。
T2S2362	Dehydrocorydaline nitrate 去氢延胡索甲素硝酸盐,硝酸脱氢紫堇碱	BCL; Others; PARP; p38 MAPK; Caspase; Parasite; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Others; Proteases/Proteasome
	Dehydrocorydaline nitrate 是生物碱。Dehydrocorydaline 调节 Bax，Bcl-2蛋白表达，激活 caspase-7，caspase-8，并使 PARP 失活。它能增强 p38 MAPK 活化，具有抗炎、抗癌、抗疟疾等功效。
T10990	Dehydrocorydaline chloride 盐酸脱氢紫堇碱,13-Methylpalmatine chloride	BCL; PARP; p38 MAPK; Caspase; Parasite; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Proteases/Proteasome
	Dehydrocorydaline chloride (13-Methylpalmatine chloride) 是生物碱。Dehydrocorydaline 调节 Bax，Bcl-2蛋白表达；激活 caspase-7，caspase-8，并使 PARP 失活。它能增强 p38 MAPK 活化，具有抗炎、抗癌等功效。它具有强大的抗疟疾作用，并具低细胞毒性。
TN2883	3',4'-Dimethoxyflavone	Others; PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair; Others
	3',4'-Dimethoxyflavone 是类黄酮化合物的参考标准，类黄酮化合物具有多种药用活性。
T5S1805	5,7-Dihydroxychromone 5,7-Dihydroxy-4H-Chromen-4-One,5,7-二羟基色酮,5,7-二羟基色原酮	Others; Virus Protease; PARP; Caspase; Nrf2	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology; Others; Proteases/Proteasome
	5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) 是一种Cudrania tricuspidata 的提取物，通过激活 Nrf2/ARE 信号对 6-OHDA 诱导的氧化应激和细胞凋亡发挥神经保护作用。它抑制 6-OHDA 诱导的 SH-SY5Y 细胞中活化的caspase-3，caspase-9以及切割的PARP 表达。
T8296	5,7,4'-Trimethoxyflavone 5,7,4'-三甲氧基黄酮,芹菜素三甲醚,4',5,7-三甲氧基黄酮,4',5,7-Trimethoxyflavone	Apoptosis; PARP; Caspase	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome
	5,7,4'-Trimethoxyflavone (4',5,7-Trimethoxyflavone) 是从泰国著名的药用植物 Kaempferia parviflora 中分离出来的一种天然产物。它以浓度依赖性方式显著有效抑制 SNU-16 人胃癌细胞的增殖，诱导细胞凋亡。
T2851	Daphnetin 7,8-Dihydroxycoumarin,Daphnetol,瑞香素	EGFR; PKA; PKC; Parasite; Autophagy	Angiogenesis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Daphnetin (7,8-Dihydroxycoumarin) 是从 Genus Daphne 中分离得到的香豆素衍生物，有抗氧化、抗炎、抗疟疾和解热作用，可用于凝血功能障碍、类风湿性关节炎等疾病的相关研究。
T4085	Paris saponin VII 重楼皂苷 VII,Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII	Apoptosis; BCL; Others; PARP; p38 MAPK; Akt; Caspase; P-gp; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; MAPK; Membrane transporter/Ion channel; Neuroscience; Others; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Paris saponin VII (Dioscini) 是从延龄草的根和根茎中分离的一种甾体皂苷。它减弱线粒体膜电位，增加凋亡相关蛋白的表达，并降低Bcl-2、caspase-9、caspase-3、PARP-1和p-Akt 的蛋白表达水平。它在 K562/ADR 细胞中诱导强烈的自噬，可研究白血病。
T40834	5-Hydroxymethyl-2'-deoxycytidine 5hmdC,2'-脱氧-5-(羟甲基)胞啶	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	5-Hydroxymethyl-2'-deoxycytidine 是 DNA 中 5-methyl-2'-deoxycytidine (5-mdC) 的氧化衍生物，引起DNA损伤反应，染色体畸变，复制叉损伤和细胞活力丧失。5-Hydroxymethyl-2’-deoxycytidine 复制叉不稳定性与染色质上聚（ADP-核糖）聚合酶1（PARP1）的存在有关。
T2860	Vanillyl Alcohol 4-Hydroxy-3-methoxybenzenemethanol,3-Methoxy-4-hydroxybenzyl alcohol,4-Hydroxy-3-methoxybenzyl alcohol,香兰醇,Vanillin alcohol,Vanillic alcohol	Apoptosis; Others	Apoptosis; Others
	Vanillyl Alcohol (3-Methoxy-4-hydroxybenzyl alcohol) 是一种酚类醇，具有抗血管生成、抗惊厥、抗炎、抗氧化、神经保护和抗伤害活性。它由香兰素衍生而来，在食品和饮料中用作调味剂。
T6S2391	L-Chicoric Acid (-)-Chicoric acid,trans-Caffeoyltartaric acid,Chicoric acid,L-菊苣酸,dicaffeoyltartaric acid,菊苣酸	Others; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	L-Chicoric Acid (trans-Caffeoyltartaric acid) 是一种二咖啡酰酒石酸，是一种选择性可逆的 HIV-1 整合酶抑制剂，IC50约为 100 nM。它还可抑制 HIV-1 复制。
TN4046	Excisanin A	MMP; FAK; PARP; GSK-3; NF-κB; Wnt/beta-catenin; Akt; Caspase; PI3K; Prostaglandin Receptor; JNK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors
	ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatment of breast cancer. Excisanin A shows comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-kappaB without affecting cell viability.Excisanin A induces apoptosis in colon cancer cell line SW620 as determined by Annexin V staining, the ...
T73403	Aviculin	Others	Others
	Aviculin 是一种木聚糖苷，是一种有效的抗癌剂 (anticanceragent)。Aviculin 可降低 MCF-7 细胞代谢活性到 50% 以下，IC50为 75.47 μM。Aviculin 通过内在凋亡途径诱导乳腺癌细胞凋亡 (apoptosis)。Aviculin 增加了 caspase-9、caspase-7和 PARP 的表达。Aviculin 使 Bax/Bcl-2 的比值升高。

天然产物

Cat.No: T8184

Synonym: 岩皂甾醇,岩藻甾醇

Target: PARP, Endogenous Metabolite, PPAR

4'-Methoxychalcone

Cat.No: T7443

Synonym: 4'-甲氧基查耳酮,4'-甲氧基查尔酮

Target: PARP, PPAR

Cat.No: T8150

Synonym: 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide,1-甲基-6-氧代吡啶-3-甲酰胺

Target: PARP, Endogenous Metabolite

Dehydrocorydaline

Cat.No: T5S2358

Synonym: Dehydrocorydalin,脱氢紫堇碱,13-Methylpalmatine

Target: BCL, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Cat.No: T6780

Synonym: Amid kyseliny benzoove,苯甲酰胺,Phenylcarboxyamide,Benzoylamide

Target: PARP, Endogenous Metabolite

Dehydrocorydaline nitrate

Cat.No: T2S2362

Synonym: 去氢延胡索甲素硝酸盐,硝酸脱氢紫堇碱

Target: BCL, Others, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Dehydrocorydaline chloride

Cat.No: T10990

Synonym: 盐酸脱氢紫堇碱,13-Methylpalmatine chloride

Target: BCL, PARP, p38 MAPK, Caspase, Parasite, Autophagy

3',4'-Dimethoxyflavone

Cat.No: TN2883

Target: Others, PARP

5,7-Dihydroxychromone

Cat.No: T5S1805

Synonym: 5,7-Dihydroxy-4H-Chromen-4-One,5,7-二羟基色酮,5,7-二羟基色原酮

Target: Others, Virus Protease, PARP, Caspase, Nrf2

5,7,4'-Trimethoxyflavone

Cat.No: T8296

Synonym: 5,7,4'-三甲氧基黄酮,芹菜素三甲醚,4',5,7-三甲氧基黄酮,4',5,7-Trimethoxyflavone

Target: Apoptosis, PARP, Caspase

Cat.No: T2851

Synonym: 7,8-Dihydroxycoumarin,Daphnetol,瑞香素

Target: EGFR, PKA, PKC, Parasite, Autophagy

Paris saponin VII

Cat.No: T4085

Synonym: 重楼皂苷 VII,Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII

Target: Apoptosis, BCL, Others, PARP, p38 MAPK, Akt, Caspase, P-gp, Autophagy

5-Hydroxymethyl-2'-deoxycytidine

Cat.No: T40834

Synonym: 5hmdC,2'-脱氧-5-(羟甲基)胞啶

Target: PARP

Vanillyl Alcohol

Cat.No: T2860

Synonym: 4-Hydroxy-3-methoxybenzenemethanol,3-Methoxy-4-hydroxybenzyl alcohol,4-Hydroxy-3-methoxybenzyl alcohol,香兰醇,Vanillin alcohol,Vanillic alcohol

Target: Apoptosis, Others

L-Chicoric Acid

Cat.No: T6S2391

Synonym: (-)-Chicoric acid,trans-Caffeoyltartaric acid,Chicoric acid,L-菊苣酸,dicaffeoyltartaric acid,菊苣酸

Target: Others, HIV Protease

Cat.No: TN4046

Target: MMP, FAK, PARP, GSK-3, NF-κB, Wnt/beta-catenin, Akt, Caspase, PI3K, Prostaglandin Receptor, JNK

Cat.No: T73403

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01188	PARP Protein, Human, Recombinant (His) ADPRT1,ADPRT,pADPRT-1,PPOL,ARTD1,...	Human	Baculovirus Insect Cells
	PARP Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 114.5 kDa and the accession number is A0A024R3T8.
TMPH-01945	TIPARP Protein, Human, Recombinant (His) ADP-ribosyltransferase diphtheria toxin-like 14,	Human	Baculovirus Insect Cells
	TIPARP Protein, Human, Recombinant (His) is expressed in Baculovirus.
TMPH-01943	PARP4 Protein, Human, Recombinant (His) Poly [ADP-ribose] polyme...	Human	E. coli
	PARP4 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-01881	PARP2 Protein, Human, Recombinant (GST & His) Protein poly-ADP-ribosyltransferase PARP2,...	Human	Baculovirus Insect Cells
	PARP2 Protein, Human, Recombinant (GST & His) is expressed in Baculovirus insect cells with N-GST and C-6xHis tag. The predicted molecular weight is 92.8 kDa and the accession number is Q9UGN5.
TMPH-01880	PARP2 Protein, Human, Recombinant (His) Protein poly-ADP-ribosyltransferase PARP2,...	Human	E. coli
	PARP2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 72.2 kDa and the accession number is Q9UGN5.
TMPH-01944	PARP9 Protein, Human, Recombinant (His & Myc) Poly [ADP-ribose] polyme...	Human	HEK293 Cells
	PARP9 Protein, Human, Recombinant (His & Myc) is expressed in HEK293.
TMPH-01879	PARP11 Protein, Human, Recombinant (His) PARP11,Poly [ADP-ribose] poly...	Human	E. coli
	Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis. PARP11 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 41.0 kDa and the accession number is Q9NR21.
TMPH-01942	PARP14 Protein, Human, Recombinant (His & Myc) Protein mono-ADP-ribosyltransferase PARP14,B aggres...	Human	HEK293 Cells
	PARP14 Protein, Human, Recombinant (His & Myc) is expressed in HEK293.
TMPY-02465	PARP Protein, Mouse, Recombinant (His) AI893648,Adprp,5830444G22Rik,C80510,sPARP-1,pol...	Mouse	Baculovirus Insect Cells
	PARP Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 115 kDa and the accession number is Q921K2.
TMPH-01882	PARP9 Protein, Human, Recombinant (His) PARP9,Poly [ADP-ribose] poly<...	Human	E. coli
	PARP9 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 30.0 kDa and the accession number is Q8IXQ6.
TMPY-02421	PARP3 Protein, Human, Recombinant (His & GST) ARTD3,IRT1,ADPRTL2,ADPRTL3,poly (...	Human	Baculovirus Insect Cells
	Poly(ADP-ribose) polymerase 3 (PARP3) is an important member of the PARP family and shares high structural similarities with both PARP1 and PARP2. Poly(ADP-ribose) polymerase 3 (PARP3), a critical player in cellular response to DNA double-strand breaks (DSBs), plays an essential role in the maintenance of genome integrity. The ADP ribosyl transferase [poly(ADP-ribose) polymerase] ARTD3(PARP3) is a newly characterized member of the ARTD(PARP) family that catalyzes the reaction of ADP ribosylation...
TMPH-01941	PARP12 Protein, Human, Recombinant (His & Myc) Protein mono-ADP-ribosyltransferase PARP12,PARP12,<...	Human	E. coli
	PARP12 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPY-02831	Caspase-7 Protein, Human, Recombinant (His) ICE-LAP3,LICE2,MCH3,CASP-7,caspase 7, apoptosis-related cyst...	Human	E. coli
	Caspase 7, also known as caspase-7 and MCH3, belongs to the cysteine-aspartic acid protease (caspase) family. Caspases play a role in the signal transduction pathways of apoptosis, necrosis and inflammation. There are two major classes of caspases: initiators and effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with, upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector caspases (-3,-6,-7) are r...

重组蛋白

PARP Protein, Human, Recombinant (His)

Cat.No: TMPY-01188

Species: Human

Expression System: Baculovirus Insect Cells

TIPARP Protein, Human, Recombinant (His)

Cat.No: TMPH-01945

Species: Human

Expression System: Baculovirus Insect Cells

PARP4 Protein, Human, Recombinant (His)

Cat.No: TMPH-01943

Species: Human

Expression System: E. coli

PARP2 Protein, Human, Recombinant (GST & His)

Cat.No: TMPH-01881

Species: Human

Expression System: Baculovirus Insect Cells

PARP2 Protein, Human, Recombinant (His)

Cat.No: TMPH-01880

Species: Human

Expression System: E. coli

PARP9 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01944

Species: Human

Expression System: HEK293 Cells

PARP11 Protein, Human, Recombinant (His)

Cat.No: TMPH-01879

Species: Human

Expression System: E. coli

PARP14 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01942

Species: Human

Expression System: HEK293 Cells

PARP Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02465

Species: Mouse

Expression System: Baculovirus Insect Cells

PARP9 Protein, Human, Recombinant (His)

Cat.No: TMPH-01882

Species: Human

Expression System: E. coli

PARP3 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02421

Species: Human

Expression System: Baculovirus Insect Cells

PARP12 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01941

Species: Human

Expression System: E. coli

Caspase-7 Protein, Human, Recombinant (His)

Cat.No: TMPY-02831

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T40394	Benzamide-15N Phenylamide-15N,Benzenecarboxamide-15N,NSC-3114-15N,Benzamide-15N
	Benzamide-15N (NSC-3114-15N) is a 15N-labeled Benzamide. Benzamide inhibits poly(ADP-ribose) polymerase (PARP).

同位素标记化合物

Cat.No: T40394

Synonym: Phenylamide-15N,Benzenecarboxamide-15N,NSC-3114-15N,Benzamide-15N

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼