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Search Results for " pluripotent "

Targets Recommended: Wnt/beta-catenin

29

抑制剂 & 化合物

3

化合物库

10

重组蛋白

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Cat. No.	Product Name
L8110	细胞重编程化合物库		1813 compounds
	1813 种重编程信号通路相关的生物活性小分子化合物的特有集合，可用于高通量、高内涵筛选
L4010	已知活性化合物库		22555 compounds
	22555 个已知活性化合物的集合，可用于高通量筛选、高内涵筛选、细胞诱导和靶点确认；
L8000	干细胞分化化合物库		1197 compounds
	1197 种干细胞分化信号通路相关的生物活性小分子化合物的特有集合，可用于高通量、高内涵筛选；

化合物库

细胞重编程化合物库

Cat.No: L8110

Compounds: 1813

已知活性化合物库

Cat.No: L4010

Compounds: 22555

干细胞分化化合物库

Cat.No: L8000

Compounds: 1197

Cat. No.	Product Name	Target	Signaling Pathways
T2052	KY02111	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	KY02111 是典型的 WNT 信号抑制剂，能够促进人多潜能干细胞向心肌细胞分化，可用于研究人类心肌细胞再生。
T2437	O4I2 O-4I2,O4I2	OCT	Membrane transporter/Ion channel
	O4I2 是一种 Oct3/4诱导剂，可增强多能干细胞相关基因 Lin28、Sox2和 Nanog 的表达，并抑制 Rex1。
T8647	BCH001	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	BCH001 是喹啉衍生物，是一种选择性PAPD5抑制剂。它可以恢复先天性角化病诱导的多能干细胞中的端粒酶活性和端粒长度。它对聚 (A)-特异性核糖核酸酶或几种其他多核苷酸聚合酶均无抑制作用。它可用于调控衰老。
T2040	OAC1 BAS 00287861	OCT	Membrane transporter/Ion channel
	OAC1 (BAS 00287861) 是一种能够激活 Octamer 结合转录因子 4 的化合物。它提高了 iPSC 重编程效率并加速重编程过程。
T1725	Y-27632 dihydrochloride 反式-4-[(R)-1-氨基乙基]-N-(4-吡啶基)环己烷甲酰胺二盐酸盐,Y-27632 2HCl	ROCK; Apoptosis	Apoptosis; Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Y-27632 dihydrochloride (Y-27632 2HCl) 是一种 ROCK-I 和 ROCK-II 抑制剂，具有口服有效性、ATP 竞争性。Y-27632 dihydrochloride 还抑制分离诱导的小鼠前列腺干或祖细胞凋亡。
T16287	Neurodazine	DNA Methyltransferase	Chromatin/Epigenetic
	Neurodazine 是一种神经性诱导剂，可促进多能细胞分化为神经元细胞。Neurodazine 通过激活 Wnt 和 Shh 信号传导促进分化。
TP1828	N-Acetyl-Ser-Asp-Lys-Pro	RAAS	Endocrinology/Hormones
	N-Acetyl-Ser-Asp-Lys-Pro 通过酶促处理胸腺素 β4 在骨髓细胞中形成。它抑制多能造血干细胞进入细胞周期的 S 期，并防止小鼠中的 Ara-C 致死性。
T3684	CP21R7 CP21	GSK-3; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Stem Cells
	CP21R7 (CP21) 是一种 GSK-3β抑制剂，其 IC50=1.8 nM。它也是一种 PKCα抑制剂，其 IC50=1900 nM。
T22814	GSA-10	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	GSA-10是新型的喹啉甲酰胺衍生物，有效激动平滑受体剂，EC50为 1.2 μM。它作用于Smo，促进多能间充质干细胞分化为成骨细胞。它介导 Hedgehog 信号传导，这可能对癌症疾病的再生医学具有研究意义。
T65070	Chenodeoxycholic Acid sodium salt CDCA sodium salt	FXR	Metabolism
	Chenodeoxycholic Acid sodium salt (CDCA sodium salt) 是一种人体中的胆汁酸，能够活化核受体 FXR，可挽救痉挛性截瘫 5 型和脑黄瘤病患者诱导多能干细胞衍生神经元的轴突变性，可用于研究胰腺坏死。
T2019	OAC2	OCT	Membrane transporter/Ion channel
	OAC2 是一种 Oct4 激活剂，通过 Oct4 基因启动子激活表达，通过提高胚胎成纤维细胞诱导多能干细胞的产生速率来提高重编程效率，是 OAC1 的类似物。
TP2339	Goralatide
	Goralatide, isolated from fetal calf bone marrow, exerts a high inhibitory activity on the proliferation of hematopoietic pluripotent stem cells.
T33652	Neurodazole	Others	Others
	Neurodazole is a neurogenic inducer for converting pluripotent P19 cells into electrophysiologically active neurons.
T36301	PluriSIn #2	Others	Others
	PluriSIn #2 acts as a selective transcriptional inhibitor of topoisomerase II α (TOP2A) and effectively eliminates undifferentiated human pluripotent stem cells (hPSCs)[1].
T23271	RSC-133	Others	Others
	promotes the reprogramming of human somatic cells to pluripotent stem cells
T70520	TWS-119	Others	Others
	TWS-119 is an inhibitor of glycogen synthase kinase-3β (GSK-3β) that induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells (ESCs).
T32416	KP-1 KP 1,KP1,Kyoto Probe 1	Others	Others
	KP-1 is a selective fluorescent probe for labeling human pluripotent stem cells.
T81698	NBD-LLLLpY
	NBD-LLLLpY Y为通过酶催化生成的核内肽，专门用于靶向毁灭人类诱导多能干细胞。
T13769	TA-316 Megakaryocytes/platelets inducing agent	Others	Others
	Megakaryocytes/platelets inducing agent being useful in treating diseases involving thrombopenia. Megakaryocytes/platelets inducing agent is an inducing agent for megakaryocytes and/or platelets from pluripotent stem cells.
T72388	CBB1007 hydrochloride	Others	Others
	CBB1007 hydrochloride，一种可逆的、选择性的高效组蛋白去甲基化酶LSD1的底物竞争性抑制剂，其对hLSD1的IC50值为5.27 uM。
T72244	CBB1007 trihydrochloride	Others	Others
	CBB1007三盐酸盐是 LSD1选择性抑制剂，IC50值为5.27uM。
T82642	Cyclo(RGDfK(Mal))
	Cyclo(RGDfK(Mal))为一种五肽，能促进人多能干细胞的附着与渗透，适用于三维干细胞培养及其扩增。
T78520	CYT296	Others	Others
	CYT296是一种靶向染色质去凝集的化合物，能增强定义因子(OSKM)介导诱导多能干细胞(iPSC)的生成，并通过诱导小鼠胚胎成纤维细胞(MEFs)染色质的开放状态来促进体细胞的重编程，适用于细胞替代治疗和药物筛选的研究领域。
T75752	N-Acetyl-Ser-Asp-Lys-Pro acetate
	N-Acetyl-Ser-Asp-Lys-Pro (Ac-SDKP) acetate 是血管紧张素转换酶 (ACE) N 端活性位点的特异性底物。N-Acetyl-Ser-Asp-Lys-Pro acetate 是多能干细胞增殖的天然抑制剂。N-Acetyl-Ser-Asp-Lys-Pro acetate 具有抗炎和抗纤维化特性。
T76068	Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA
	Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA 是一种环状RGD多肽，对αvβ3有高亲和性，能干扰细胞整合素之间的相互作用。此化合物能抑制胚胎干细胞(ESC)的多潜能性基因表达，并可在体内减少mESC的致瘤潜力，因此适用于肿瘤研究领域。
T85259	N-Oleoyl serinol Oleoyl serinol	Others	Others
	N-Oleoyl serinol是一种用于干细胞治疗中防止干细胞演化为畸胎瘤的神经酰胺类似物。该化合物能够诱导残留的多能胚状体衍生细胞(EBC)的凋亡(apoptosis)，有效避免畸胎瘤的形成，并促进了移植后神经分化EBC细胞的增加。
T35541	Lipoxygenin	Others	Others
	Lipoxygenin is an inhibitor of 5-lipoxygenase (5-LO) with an IC50value of 5 μM for inhibition of 5-LO product synthesis in isolated human granulocytes stimulated with the cation ionophore A23187 .1It inhibits hedgehog-dependent signaling in Shh-LIGHT2 cells and TGF-β-, activin A-, bone morphogenic protein (BMP)-, or Wnt-dependent signaling in HEK293T cells (IC50s = 9.3, 3.2, 8.2, 9.6, and 3.7 μM, respectively, in luciferase reporter assays). Lipoxygenin (5 and 10 μM) increases levels of troponin...
T35567	BIX01294 (hydrochloride hydrate)	Others	Others
	The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development. BIX01294 (hydrochloride hydrate) is a selective inhibitor of G9a HMTase (IC50 = 1.7 μM). It less effectively inhibits the HMTase G9a-like protein (GLP; IC50 = 38 μM) and has no effect on other ...
T74247	TPE-MI
	TPE-MI（Tetraphenylethene maleimide）在与马来酰亚胺与硫醇反应前不具荧光性。在与游离的半胱氨酸硫醇标记时，其荧光被激活，后者多在球形蛋白质的核心，仅在展开时显露。TPE-MI适用于测量细胞中未折叠蛋白质的负荷，并能在亨廷顿病诱导的多能干细胞模型中监测蛋白质平衡失衡，以及在形成可见聚合体之前，监测转染突变亨廷顿外显子1的细胞的状况。此外，TPE-MI用于检测双氢青蒿素处理后疟疾寄生虫的蛋白质损伤。应暗处储存。

化合物

Cat.No: T2052

Target: Wnt/beta-catenin

Cat.No: T2437

Synonym: O-4I2,O4I2

Target: OCT

Cat.No: T8647

Target: DNA/RNA Synthesis

Cat.No: T2040

Synonym: BAS 00287861

Target: OCT

Y-27632 dihydrochloride

Cat.No: T1725

Synonym: 反式-4-[(R)-1-氨基乙基]-N-(4-吡啶基)环己烷甲酰胺二盐酸盐,Y-27632 2HCl

Target: ROCK, Apoptosis

Cat.No: T16287

Target: DNA Methyltransferase

N-Acetyl-Ser-Asp-Lys-Pro

Cat.No: TP1828

Target: RAAS

Cat.No: T3684

Synonym: CP21

Target: GSK-3, PKC

Cat.No: T22814

Target: Hedgehog/Smoothened

Chenodeoxycholic Acid sodium salt

Cat.No: T65070

Synonym: CDCA sodium salt

Target: FXR

Cat.No: T2019

Target: OCT

Cat.No: TP2339

Cat.No: T33652

Target: Others

Cat.No: T36301

Target: Others

Cat.No: T23271

Target: Others

Cat.No: T70520

Target: Others

Cat.No: T32416

Synonym: KP 1,KP1,Kyoto Probe 1

Target: Others

Cat.No: T81698

Cat.No: T13769

Synonym: Megakaryocytes/platelets inducing agent

Target: Others

CBB1007 hydrochloride

Cat.No: T72388

Target: Others

CBB1007 trihydrochloride

Cat.No: T72244

Target: Others

Cyclo(RGDfK(Mal))

Cat.No: T82642

Cat.No: T78520

Target: Others

N-Acetyl-Ser-Asp-Lys-Pro acetate

Cat.No: T75752

Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA

Cat.No: T76068

N-Oleoyl serinol

Cat.No: T85259

Synonym: Oleoyl serinol

Target: Others

Cat.No: T35541

Target: Others

BIX01294 (hydrochloride hydrate)

Cat.No: T35567

Target: Others

Cat.No: T74247

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00051	IL-3 Protein, Mouse, Recombinant (His) Mast cell growth factor,Il3,Multipotential colony-stimulatin...	Mouse	HEK293 Cells
	Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. In addition, IL-3 also affects the functional activity of mature mast cells, basophils, eosinophils and macrophages.Because of its multiple functions and targets, it was originally studied under different names, including mast cell growth factor P-cell stimulating factor, bu...
TMPK-00077	EPO/Erythropoietin Protein, Human, Recombinant EPO,MVCD2,红细胞生长素,Epoetin,Erythropoietin,EP	Human	HEK293 Cells
	Erythropoietin (EPO) is a circulating hormone conventionally considered to be responsible for erythropoiesis. In addition to facilitating red blood cell production, EPO has pluripotent potential, such as for cognition improvement, neurogenesis, and anti-fibrotic, anti-apoptotic, anti-oxidative, and anti-inflammatory effects.
TMPK-00049	IL-3 Protein, Mouse, Recombinant (hFc) IL3,MULTI-CSF,MCGF,白细胞介素,IL-3MGC79398,IL-3,白介素,interleukin-3	Mouse	HEK293 Cells
	Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes. IL-3 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 42.2 kDa and the accession num...
TMPK-00655	IL-3 Protein, Cynomolgus, Recombinant (His) MCGF,IL3,MULTI-CSF,IL-3MGC79398,interleukin-3,IL-3	Cynomolgus	E. coli
	Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes. IL-3 Protein, Cynomolgus, Recombinant (His) is expressed in E. coli expression system with N-His tag. The predicted molecular weight is 15.13 kDa and the acce...
TMPK-00032	IL-3 Protein, Human, Recombinant (His & Avi), Biotinylated 白细胞介素,白介素,interleukin-3,MULTI-CSF,IL-3,IL3,IL-3MGC79398,MCGF	Human	E. coli
	Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes. IL-3 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in E. coli expression system with N-His-Avi tag. The predicted molecular weight is 16....
TMPK-00590	IL-3 Protein, Human, Recombinant (E. coli) interleukin-3,IL-3,MULTI-CSF,MCGF,IL-3MGC79398,IL3	Human	E. coli
	Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes. IL-3 Protein, Human, Recombinant（E. coli） is expressed in E. coli expression system. The predicted molecular weight is 15.09 kDa and the accession number is A...
TMPK-00033	IL-3 Protein, Human, Recombinant (hFc) IL3,interleukin-3,IL-3,MULTI-CSF,白介素,白细胞介素,IL-3MGC79398,MCGF	Human	HEK293 Cells
	Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes. IL-3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 41.6 kDa and the accession num...
TMPK-00031	IL-3 Protein, Human, Recombinant (His & Avi) IL-3,IL3,IL-3MGC79398,白介素,interleukin-3,MULTI-CSF,白细胞介素,MCGF	Human	E. coli
	Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes. IL-3 Protein, Human, Recombinant (His & Avi) is expressed in E. coli expression system with N-His-Avi tag. The predicted molecular weight is 16.9 kDa and the ...
TMPY-01118	SLC27A4/FATP4 Protein, Human, Recombinant (His) FATP4,IPS,solute carrier family 27 (fatty acid transporter),...	Human	HEK293 Cells
	SLC27A4/ATG4B complex might act as a new potential therapeutic target of lung tumor chemotherapy. The solute carrier 27A (SLC27A) gene family encodes fatty acid transport proteins (FATPs) and includes 6 members. Autism spectrum disorders (ASD) are now recognized as disorders caused by impaired early brain development, it is possible that functional abnormalities of SLC27A genes may contribute to the pathogenesis of ASD. The expression of SLC27A3 and SLC27A4 in human neural stem cells derived fro...
TMPH-01288	Elongin-B Protein, Human, Recombinant (GST) EloB,Elongin-B,TCEB2,ELOB,SIII p18	Human	E. coli
	SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region ...

重组蛋白

IL-3 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00051

Species: Mouse

Expression System: HEK293 Cells

EPO/Erythropoietin Protein, Human, Recombinant

Cat.No: TMPK-00077

Species: Human

Expression System: HEK293 Cells

IL-3 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00049

Species: Mouse

Expression System: HEK293 Cells

IL-3 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00655

Species: Cynomolgus

Expression System: E. coli

IL-3 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00032

Species: Human

Expression System: E. coli

IL-3 Protein, Human, Recombinant (E. coli)

Cat.No: TMPK-00590

Species: Human

Expression System: E. coli

IL-3 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00033

Species: Human

Expression System: HEK293 Cells

IL-3 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00031

Species: Human

Expression System: E. coli

SLC27A4/FATP4 Protein, Human, Recombinant (His)

Cat.No: TMPY-01118

Species: Human

Expression System: HEK293 Cells

Elongin-B Protein, Human, Recombinant (GST)

Cat.No: TMPH-01288

Species: Human

Expression System: E. coli

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