Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7020 |
Z-VAD-FMK
Z-VAD(OH)-FMK,Caspase Inhibitor VI,Z-VAD |
Caspase | Apoptosis; Proteases/Proteasome |
Z-VAD-FMK (Caspase Inhibitor VI) 是一种 caspase 的广谱抑制剂。Z-VAD-FMK 可以与活化的 caspase 结合,从而抑制细胞凋亡。Z-VAD-FMK即使在高达 440μM 的浓度下也不会抑制 UCHL1 的活性。 | |||
T0282 |
Q-VD-OPH
Quinoline-Val-Asp-Difluorophenoxymethylketone |
Caspase; HIV Protease | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Q-VD-OPH (Quinoline-Val-Asp-Difluorophenoxymethylketone) 是一种具有强效抗凋亡特性的泛半胱天冬酶抑制剂。它可抑制 HIV 感染,能透过血脑屏障。 | |||
T6013 |
Z-VAD(OMe)-FMK
Z-VAD-FMK,Z-Val-Ala-Asp(OMe)-FMK |
Caspase | Apoptosis; Proteases/Proteasome |
Z-VAD(OMe)-FMK 是一种具有不可逆特性的pan-caspase抑制剂。Z-VAD(OMe)-FMK 还是泛素 C 端水解酶 L1 (UCHL1) 的抑制剂,它通过靶向 UCHL1 活性位点进行不可逆修饰。 | |||
T6826 |
Emricasan
PF 03491390,恩利卡生,IDN-6556 |
Influenza Virus; Caspase | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Emricasan (IDN-6556) 是一种泛的 caspase 抑制剂,具有不可逆性。Emricasan 具有抗炎和抗凋亡活性,可以用于治疗感染和肝衰竭等。Emricasan 还可以抑制 Zika 病毒感染。 | |||
T21293 |
MX1013
MX 1013,MX-1013 |
Others | Others |
MX1013, a dipeptide pan-caspase inhibitor, inhibits caspase-1, -3, -6, -7, -8, and -9. | |||
T80624 |
Ac-VAD-CHO
Ac-Val-Ala-Asp-CHO |
Caspase | Apoptosis; Proteases/Proteasome |
Ac-VAD-CHO (Ac-Val-Ala-Asp-CHO)是一款caspase抑制剂,能够阻止缺氧细胞内MMP的降解以及细胞色素c的释出。 | |||
T13445 |
(R)-Q-VD-OPh
(R)-Quinoline-Val-Asp-Difluorophenoxymethylketone,(R)-QVD-OPH |
Others | Others |
(R)-Q-VD-OPh is the less active enantiomer of Q-VD-OPha. Q-VD-OPha is an irreversible inhibitor of pan-caspase, with potent antiapoptotic properties. | |||
T39586 |
Cantrixil
TRX-E-002-1 |
Others | Others |
Cantrixil (TRX-E-002-1) is a second-generation super-benzopyran (SBP) compound, derived from TRX-E-002. It elicits an increase in phosphorylated c-Jun levels, leading to caspase-mediated apoptosis in ovarian cancer cells. Cantrixil exhibits potent pan anti-cancer activity against various cancer phenotypes. | |||
T69200 |
CGP74514A
|
Others | Others |
CGP74514A is a CDK1 inhibitor with potential anticancer activity. In U937 cells, CGP74514A - induced apoptosis (5 microM) became apparent within 4 hr and approached 100% by 24 hr. The pan- caspase inhibitor Boc-fmk and the caspase-8 inhibitor lETD-fmk opposed CGP74514A -induced caspase-9 activation and PARP degradation, but not cytochrome c or Smac/DIABLO release. CGP74514A -mediated apoptosis was substantially blocked by ectopic expression of full-length Bel- 2, a loop-deleted mutant Bcl-2, and... | |||
T75010 |
TD1092
|
Others | Others |
TD1092 是一种泛凋亡抑制蛋白 (IAP) 降解剂,可降解 cIAP1,cIAP2和 XIAP。TD1092 激活细胞凋亡蛋白酶 (apoptosis3/7),并通过促进 IAP 降解,导致癌细胞凋亡 (apoptosis)。同时,TD1092 还能够阻断 TNFα介导的 NF-κB 信号通路,抑制 IKK,IkBα,p65,和 p38 的磷酸化。TD1092 可作为 PROTAC,用于癌症研究。 |