|
TMPY-04460
|
OXSR1 Protein, Human, Recombinant (GST)
OSR1,oxidative stress responsive 1
|
Human
|
Baculovirus Insect Cells
|
|
Oxidative stress-responsive 1 protein (OXSR1), also known as Serine/threonine-protein kinase OSR1, is a member of the Ser/Thr protein kinase family of proteins. OXSR1 regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. OXSR1 is a 58 kDa protein of 527 amino acids that is widely expressed in mammalian tissues and cell lines. The amino acid (aa) sequence of the predicted OXSR1 protein is 39% identical to that of human SOK1. Of... |
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TMPY-00541
|
LON PROTEASE Protein, E. coli, Recombinant (His)
|
E. coli
|
E. coli
|
|
Lon protease, an ATP-dependent mitochondrial protease, is important in mitochondrial protein maintenance. Lon protease is a multifunctional enzyme, and its functions include the degradation of damaged proteins and naturally short-lived proteins, ATPase and chaperone-like activities, as well as DNA binding. Lon protease plays a major role in the protein quality control system in mammalian cell mitochondria. It is present in the mitochondrial matrix and degrades oxidized and misfolded proteins, th... |
|
TMPY-03962
|
AFM Protein, Human, Recombinant (His)
afamin,ALBA,ALB2,ALF
|
Human
|
HEK293 Cells
|
|
Afamin is an 87 kDa glycoprotein with five predicted N-glycosylation sites. Afamin's glycan abundance contributes to conformational and chemical inhomogeneity presenting great challenges for molecular structure determination. Afamin, a human plasma glycoprotein and putative transporter of hydrophobic molecules, has been shown to act as extracellular chaperone for poorly soluble, acylated Wnt proteins, forming a stable, soluble complex with functioning Wnt proteins. The 2.1-Å crystal structure of... |
|
TMPY-02043
|
PARK7/DJ-1 Protein, Human, Recombinant (His)
DJ1,HEL-S-67p,DJ-1,parkinson protein 7
|
Human
|
E. coli
|
|
Parkinson's disease locus DJ-1 (PARK7) is a differentially expressed transcript. DJ-1 plays a physiologic role in protection of erythroid cells from oxidant damage, a function unmasked in the context of oxidative stress. PARK7 belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress... |
|
TMPH-02681
|
GPX7 Protein, Mouse, Recombinant (His & Myc)
Glutathione peroxidase 7,Gpx7
|
Mouse
|
E. coli
|
|
It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks. GPX7 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 26.7 kDa and the accession number is Q99LJ6. |
|
TMPH-00641
|
YTFE Protein, E. coli, Recombinant (GST)
Regulator of cell morphogenesis and NO signaling,Iron-sulfur...
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E. coli
|
E. coli
|
|
Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions. YTFE Protein, E. coli, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 51.9 kDa and the accession number is P69506. |
|
TMPH-03275
|
Cytoglobin Protein, Rat, Recombinant (His & Myc)
Stellate cell activation-associated protein,Stap,CYGB,Cytogl...
|
Rat
|
E. coli
|
|
May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer. Plays a role in the development of liver fibrosis. Has a peroxidase activity. |
|
TMPH-03443
|
GPX2 Protein, S. cerevisiae, Recombinant (His & Myc)
Glutathione peroxidase homolog 2,Glutathione peroxidase-like...
|
Saccharomyces cerevisiae
|
E. coli
|
|
Glutathione peroxidase-like protein that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress. Plays an important role in the oxidative stress-induced response in the presence of Ca(2+). Has peroxidase activity using preferentially thioredoxin as a reducing power. The redox state of the mitochondrial GPX2 is regulated by TRX1 and TRX2 (cytoplasmic thioredoxin), and by TRX3 (mitochondrial matrix thioredoxin). Involved in sporulation. GPX2 Protein, ... |
|
TMPH-03054
|
Asp f3 Protein, Neosartorya fumigata, Recombinant (His & SUMO)
|
Neosartorya fumigata
|
E. coli
|
|
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Required for virulence. |
|
TMPY-02299
|
ALDH3A1 Protein, Human, Recombinant (His)
ALDHIII,aldehyde dehydrogenase 3 family, member A1,ALDH3
|
Human
|
Baculovirus Insect Cells
|
|
Aldehyde dehydrogenase 3A1 (ALDH3A1) is a metabolic enzyme that catalyzes the oxidation of various aldehydes. Certain types of epithelial tissues in mammals, especially those continually exposed to environmental stress (e.g., corneal epithelium), express ALDH3A1 at high levels and its abundance in such tissues is perceived to help to maintain cellular homeostasis under conditions of oxidative stress. Metabolic as well as non-metabolic roles for ALDH3A1 have been associated with its mediated resi... |
|
TMPH-01397
|
LANCL1 Protein, Human, Recombinant (His & Myc)
LANCL1,40 kDa erythrocyte membrane protein,Glutathione S-tra...
|
Human
|
E. coli
|
|
Functions as glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism. May play a role in EPS8 signaling. Binds glutathione. LANCL1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc... |
|
TMPJ-01248
|
Cytoglobin/CYGB Protein, Human, Recombinant (His)
Stellate Cell Activation-Associated Protein,Cytoglobin,CYGB,...
|
Human
|
E. coli
|
|
Cytoglobin is a ubiquitously globin protein that belongs to the globin family. The highest expressed in heart, stomach, bladder and small intestine. CYGB acts a protector under conditions of oxidative stress. CYGB may be involved in intracellular oxygen storage or transfer, modulates oxygen and nitric oxide metabolism or scavenging free radicals within a cell. |
|
TMPH-03721
|
IbpA Protein, Yersinia pestis bv. Antiqua, Recombinant (His)
Small heat shock protein IbpA,16 kDa heat shock protein A,ib...
|
Yersinia pestis
|
E. coli
|
|
Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent. |
|
TMPH-02153
|
Sulfiredoxin-1 Protein, Human, Recombinant (His & Myc)
SRXN1,Sulfiredoxin-1
|
Human
|
E. coli
|
|
Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase. |
|
TMPH-00072
|
2-Cys Prx A Protein, Arabidopsis thaliana, Recombinant (His)
Thioredoxin-dependent peroxiredoxin BAS1,2-Cys peroxiredoxin...
|
Arabidopsis thaliana
|
P. pastoris (Yeast)
|
|
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. May be an antioxidant enzyme particularly in the developing shoot and photosynthesizing leaf. 2-Cys Prx A Protein, Arabidopsis thaliana, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 24.4 kDa and the accession number is Q96291. |
|
TMPJ-00720
|
TXNDC12 Protein, Human, Recombinant (His)
TLP19,ERp19,Thioredoxin Domain-Containing Protein 12,hTLP19,...
|
Human
|
HEK293 Cells
|
|
Thioredoxin Domain-Containing Protein 12 belongs to the thioredoxin superfamily. In this family, proteins possess a thioredoxin fold with a consensus active-site sequence (CxxC) and have roles in redox regulation, defense against oxidative stress, refolding of disulfide-containing proteins, and regulation of transcription factors. TXNDC12 is widely expressed in many tissues and contains one thioredoxin domain. |
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TMPH-02199
|
TXNRD2 Protein, Human, Recombinant (His)
Thioredoxin-dependent peroxide reductase, mitochondrial,Pero...
|
Human
|
E. coli
|
|
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. TXNRD2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 25.5 kDa and the accession number is P30048. |
|
TMPJ-01076
|
FKBP4 Protein, Human, Recombinant (His)
FKBP4,HSP-binding immunophilin,immunophilin FKBP52,FK506-bin...
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Human
|
E. coli
|
|
FKBP4 act as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments, it also may have a protective role against oxidative stress in mitochondria. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. |
|
TMPH-00794
|
Dps Protein, Helicobacter pylori, Recombinant (His & SUMO)
napA,DNA protection during starvation protein,Bacterioferrit...
|
Helicobacter pylori
|
E. coli
|
|
Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction. Required for the survival in the presence of oxidative stress. Dps is also a virulence factor that activates neutrophils, mast cells and monocytes. It binds to neutrophil-glycosphingolipids and to sulfated carbohydrates on mucin. It might have a role... |
|
TMPJ-00379
|
AOC3 Protein, Human, Recombinant (hFc)
SSAO,AOC3,Membrane primary amine oxidase,Copper amine oxidas...
|
Human
|
HEK293 Cells
|
|
Membrane primary amine oxidase(AOC3), also known as vascular adhesion protein (VAP-1) and HPAO, this protein is a member of the semicarbazide-sensitive amine oxidase (SSAO) family. VAP-1 is a type 1 membrane-bound glycoprotein that has a distal adhesion domain and an enzymatically active amine oxidase site outside of the membrane, VAP-1 has adhesive properties, functional monoamine oxidase activity, and possibly plays a role in glucose handling, leukocyte trafficking, and migration during inflam... |
|
TMPY-02201
|
Peroxiredoxin 6 Protein, Human, Recombinant (His)
p29,PRX,1-Cys,HEL-S-128m,peroxiredoxin 6,NSGPx,AOP2,aiPLA2
|
Human
|
E. coli
|
|
PRDX6, a member of antioxidant protein superfamily, plays an important role in oxidative stress, catabolism of lipids and phospholipid lipisomes. Peroxiredoxin 6 (PRDX6) is involved in redox regulation of the cell and is thought to be protective against oxidant injury. Peroxiredoxin 6 (PRDX6) is a bifunctional protein with both glutathione peroxidase (GPx) and iPLA2 activities，which are concomitantly increased with the expression of PRDX6. PRDX6 promoted lung tumor growth in an in vivo allograft... |
|
TMPY-02544
|
FANCA Protein, Human, Recombinant (His)
FA-H,FA1,FAA,FAH,FANCH,FACA,Fanconi anemia, complementation ...
|
Human
|
Baculovirus Insect Cells
|
|
FANCA is one of the six known Fanconi anemia gene products (FANCA, FANCC, FANCD2, FANCE, FANCF, and FANCG proteins). Fanconi anemia (FA) is a genetic disorder predisposing to aplastic anemia and cancer characterized by hypersensitivity to DNA-damaging agents and oxidative stress. FANCA associates with the IκB kinase (IKK) signalsome via interaction with IKK2. Components of the FANCA complex undergo rapid, stimulus-dependent changes in phosphorylation, which are blocked by kinase-inactive IKK2. |
|
TMPK-01168
|
LOX-1 Protein, Mouse, Recombinant (His)
LOXIN,LOX-1,CLEC8A,Ox-LDL receptor 1,SLOX1,LOX1,SCARE1,SR-E1...
|
Mouse
|
HEK293 Cells
|
|
LOX-1 is a transmembrane glycoprotein that binds to and internalizes ox-LDL.LOX-1 gene deletion in mice and anti-LOX-1 therapy has been shown to decrease inflammation, oxidative stress and atherosclerosis. LOX-1 deletion also results in damage from ischemia, making LOX-1 a promising target of therapy for atherosclerosis and related disorders. In this article we focus on the different mechanisms for regulation, signaling and the various effects of LOX-1 in contributing to atherosclerosis. |
|
TMPJ-00105
|
SOD2 Protein, Human, Recombinant (His)
Superoxide Dismutase [Mn] Mitochondrial,SOD2
|
Human
|
HEK293 Cells
|
|
Superoxide Dismutase (SOD2) belongs to the iron/manganese superoxide dismutase family. SOD2 is a mitochondrial matrix protein that forms a homotetramer and binds one manganese ion per subunit. SOD2 transforms toxic superoxide, a byproduct of the mitochondrial electron transport chain into hydrogen peroxide and diatomic oxygen. It is reported that oxidative stress plays an essential role in the development of breast cancer, while SOD2 is one of the primary enzymes that directly convert potential ... |
|
TMPK-00693
|
HSP27/HSPB1 Protein, Human, Recombinant (His)
Hsp27,SRP27,HMN2B,HSP 27,HSPB1,CMT2F,HSP28
|
Human
|
E. coli
|
|
Heat shock protein beta-1 (HSPB1, also known as HSP27) is a small heat shock protein involved in many cellular processes and reportedly protects cells against oxidative stress. This protein is expressed only in insulin-dependent tissues (heart, skeletal muscle, and fat tissue), and expression of HspB7 is regulated by many different factors. HspB7 has an unusual N-terminal sequence, a conservative α-crystallin domain, and very short C-terminal domain lacking conservative IPV tripeptide involved i... |
|
TMPY-02072
|
HSF1 Protein, Human, Recombinant (His)
HSTF1,heat shock transcription factor 1
|
Human
|
E. coli
|
|
Heat shock factor protein 1, also known as heat shock transcription factor 1, HSF1, and HSTF1, is a cytoplasm and nucleus protein that belongs to the HSF family. HSF1 is the major transcription factor of HSPs (heat shock proteins) in response to various stresses. Wild type HSF1 (heat shock transcriptional factor 1) is normally inactive. HSF1 / HSTF1 is a DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable... |
|
TMPH-01502
|
Humanin Protein, Human, Recombinant (GST)
Humanin,Humanin mitochondrial,MT-RNR2
|
Human
|
E. coli
|
|
Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective effect by interacting with a receptor complex composed of IL6ST/GP130, IL27RA/WSX1 and CNTFR. Also acts as a ligand for G-protein coupled receptors FPR2/FPRL1 and FPR3/FPRL2. Inhibits amyloid-beta protein 40 fibril formation. Also inhibits amyloid-beta protein 42 fibril formation.... |
|
TMPY-00450
|
H Cadherin Protein, Mouse, Recombinant (His)
Cdht,T-cadherin,cadherin 13,4932416G01Rik,Tcad
|
Mouse
|
HEK293 Cells
|
|
CDH13, also known as cadherin-13 and H Cadherin, is a member of the cadherin superfamily. CDH13 acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. CDH13 is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. CDH13 gene is hypermethylated in many types of cancer. H Cadheri... |
|
TMPH-02661
|
Frataxin/FXN Protein, Mouse, Recombinant (E. coli, His)
Fxn,Frataxin, mitochondrial
|
Mouse
|
E. coli
|
|
Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activit... |
|
TMPH-02660
|
Frataxin/FXN Protein, Mouse, Recombinant (His)
Fxn,Frataxin, mitochondrial
|
Mouse
|
P. pastoris (Yeast)
|
|
Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activit... |
|
TMPY-01588
|
ALDH7A1 Protein, Human, Recombinant (His)
ATQ1,aldehyde dehydrogenase 7 family, member A1,EPD,PDE
|
Human
|
E. coli
|
|
ALDH7A1 (Aldehyde dehydrogenase 7 family, member A1) is a member of subfamily 7 in the aldehyde dehydrogenase family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Mammalian ALDH7A1 is homologous to plant ALDH7B1 which protects against various forms of stress such as increased salinity, dehydration and treatment with oxidants or pesticides. In mammals, ALDH7A1 is known to play a primary role during lysine... |
|
TMPH-01503
|
Humanin Protein, Human, Recombinant (hFc)
MT-RNR2,Humanin,Humanin mitochondrial
|
Human
|
HEK293 Cells
|
|
Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective effect by interacting with a receptor complex composed of IL6ST/GP130, IL27RA/WSX1 and CNTFR. Also acts as a ligand for G-protein coupled receptors FPR2/FPRL1 and FPR3/FPRL2. Inhibits amyloid-beta protein 40 fibril formation. Also inhibits amyloid-beta protein 42 fibril formation.... |
|
TMPY-03798
|
H Cadherin Protein, Rat, Recombinant (His)
cadherin 13
|
Rat
|
HEK293 Cells
|
|
CDH13, also known as cadherin-13 and H Cadherin, is a member of the cadherin superfamily. CDH13 acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. CDH13 is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. CDH13 gene is hypermethylated in many types of cancer. H Cadheri... |
|
TMPY-00601
|
H Cadherin Protein, Mouse, Recombinant (hFc)
Tcad,T-cadherin,4932416G01Rik,cadherin 13,Cdht
|
Mouse
|
HEK293 Cells
|
|
CDH13, also known as cadherin-13 and H Cadherin, is a member of the cadherin superfamily. CDH13 acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. CDH13 is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. CDH13 gene is hypermethylated in many types of cancer. H Cadheri... |
|
TMPY-03948
|
H Cadherin Protein, Rat, Recombinant
cadherin 13
|
Rat
|
HEK293 Cells
|
|
CDH13, also known as cadherin-13 and H Cadherin, is a member of the cadherin superfamily. CDH13 acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. CDH13 is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. CDH13 gene is hypermethylated in many types of cancer. H Cadheri... |
|
TMPY-03823
|
H Cadherin Protein, Rat, Recombinant (hFc)
cadherin 13
|
Rat
|
HEK293 Cells
|
|
CDH13, also known as cadherin-13 and H Cadherin, is a member of the cadherin superfamily. CDH13 acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. CDH13 is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. CDH13 gene is hypermethylated in many types of cancer. H Cadheri... |
|
TMPY-04260
|
p38 Protein, Human, Recombinant (His)
mitogen-activated protein kinase 14,CSPB1,PRKM14,RK,p38α,CSB...
|
Human
|
Baculovirus Insect Cells
|
|
MAPK14 contains 1 protein kinase domain and belongs to the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. MAPK14 can be detected in the brain, heart, placenta, pancreas, and skeletal muscle and it is expressed to a lesser extent in the lung, liver, and kidney. MAPK14 is activated by various environmental stresses ... |
|
TMPJ-00380
|
AOC3 Protein, Human, Recombinant (His)
Membrane primary amine oxidase,HPAO,VAP-1,Semicarbazide-sens...
|
Human
|
HEK293 Cells
|
|
Vascular adhesion protein-1(VAP-1) is a copper amine oxidase with a topaquinone cofactor.VAP-1 is a type II integral membrane protein, but a soluble form of the enzyme is present in human serum, and its level increases in diabetes and some inflammatory liver diseases. VAP-1 catalyzes the oxidative deamination of small primary amines such as methylamine, benzylamine, and aminoacetone in a reaction that produces an aldehyde, ammonia, and H2O2. VAP-1 vascular expression is regulated at sites of inf... |
|
TMPY-04406
|
Protein Kinase D2/PRKD2 Protein, Human, Recombinant (His & GST)
protein kinase D2,nPKC-D2,PKD2,HSPC187
|
Human
|
Baculovirus Insect Cells
|
|
Serine/threonine-protein kinase D2, also known as PRKD2 and PKD2, is a cytoplasm and membrane protein that belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family and PKD subfamily. PRKD2 / PKD2 is widely expressed. It contains one PH domain, two phorbol-ester/DAG-type zinc fingers and one protein kinase domain. PRKD2 / PKD2 is activated by DAG and phorbol esters. Phorbol-ester/DAG-type domains bind DAG, mediating translocation to membranes. Autophosphorylation of Ser-71 an... |
|
TMPY-01770
|
HAO1 Protein, Human, Recombinant (His)
GOX1,hydroxyacid oxidase (glycolate oxidase) 1,GOX,HAOX1
|
Human
|
E. coli
|
|
Hydroxyacid oxidase 1, also known as Glycolate oxidase, HAO1, and GOX1, is a member of the FMN-dependent alpha-hydroxy acid dehydrogenase family. HAO1 / GOX1 has 2-hydroxyacid oxidase activity. It is most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate. HAO1 / GOX1 is a liver-specific peroxisomal enzyme that oxidizes glycolate to glyoxylate with the concomitant production of H2O2. In H... |
|
TMPY-02482
|
Aconitase 1 Protein, Human, Recombinant (His)
HEL60,IRP1,ACONS,aconitase 1, soluble,IREBP,IREBP1,IREB1
|
Human
|
Baculovirus Insect Cells
|
|
Aconitase 1(ACO1) or IRP1 is one member of the aconitase family that contains a diverse group of iron-sulphur(Fe-S) isomerases and two types of iron regulatory protein. Aconitase exits in two forms: one is soluble and the other is mitochondrial. ACO1 is the soluble existing form, and the mitochondrial form is ACO2. Residues from all three N-terminal domains and the larger C-terminal domain contribute to the active site region. When the enzyme is activated, it gains an additional iron atom. ACO1 ... |
|
TMPY-02843
|
GPX7 Protein, Human, Recombinant (hFc)
GSHPx-7,UNQ469/PRO828,NPGPx,CL683,glutathione peroxidase 7,G...
|
Human
|
HEK293 Cells
|
|
GPX7 gene contains 3 distinct gt-ag introns. Transcription produces 4 different mRNAs, 3 alternatively spliced variants, and 1 unspliced form. There are 5 validated alternative polyadenylation sites. The mRNAs appear to differ by overlapping exons with different boundaries. GPX7 is an enzyme. It has molecular functions (glutathione peroxidase activity, oxidoreductase activity) and to localize in various compartments (extracellular space, extracellular region). GPX7 gene has been proposed to part... |
|
TMPY-01614
|
VNN2 Protein, Human, Recombinant (His)
vanin 2,FOAP-4,VNN2,GPI-80
|
Human
|
HEK293 Cells
|
|
Vascular non-inflammatory molecule 2, also known as glycosyl-phosphatidyl inositol-anchored protein GPI-8, Vanin-2, Protein FOAP-4 and VNN2, is a cell membrane protein that belongs to the CN hydrolase family and Vanin subfamily. VNN2 is widely expressed with higher expression in spleen and blood. VNN2 is a member of the vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a fe... |
|
TMPY-04122
|
ATOX1 Protein, Human, Recombinant (His)
HAH1,ATX1,antioxidant 1 copper chaperone
|
Human
|
E. coli
|
|
ATOX1 is a cytoplasmic copper chaperone that interacts with the copper-binding domain of the membrane copper transporters ATP7A and ATP7B. ATOX1 has also been suggested to have a potential anti-oxidant activity. As the trace element copper is essential, but extremely toxic in high concentrations, intracellular copper concentrations are tightly controlled. Once in the cell, copper is distributed by metallochaperones, including the small cytoplasmic protein ATOX1. ATOX1 plays an important role in ... |
|
TMPY-02084
|
Thioredoxin 2/TRX2 Protein, Human, Recombinant (His)
MT-TRX,RP5-1119A7. 13-005,TRX2,MTRX,thioredoxin 2
|
Human
|
E. coli
|
|
Thioredoxin-2, also known as TXN2, MTRX and TRX2, is a member of the thioredoxin family. Tryparedoxins (TXN) are thioredoxin-related proteins which, as trypanothione:peroxiredoxin oxidoreductases, constitute the trypanothione-dependent antioxidant defense and may also serve as substrates for ribonucleotide reductase in trypanosomatids. Thioredoxin-2 / TXN2 contains one thioredoxin domain. It is widely expressed in adult (at protein level) and fetal tissues. Human Thioredoxin-2 / TXN2 is a small ... |
|
TMPH-02539
|
MGAT3 Protein, Mouse, Recombinant (His & Myc)
Mgat3,Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosam...
|
Mouse
|
E. coli
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It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains, called bisecting N-acetylglucosamine (GlcNAc). It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. The addition of this bisecting GlcNAc residue alters not only the composition,... |
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TMPH-03264
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p53 Protein, Rat, Recombinant (His)
Tumor suppressor p53,Tp53,Cellular tumor antigen p53
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Rat
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E. coli
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Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 ex... |
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TMPH-02574
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p53 Protein, Mouse, Recombinant (His & SUMO)
Tp53,Cellular tumor antigen p53,Tumor suppressor p53
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Mouse
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E. coli
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Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 ex... |
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TMPY-04456
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PKC nu Protein, Human, Recombinant (GST)
PRKCN,nPKC-NU,PKC-NU,PKD3,EPK2,protein kinase D3
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Human
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Baculovirus Insect Cells
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Serine/threonine-protein kinase D3, also known as Protein kinase C nu type, Protein kinase EPK2, PRKD3, EPK2 and PRKCN, is a cytoplasm and membrane protein that belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family and PKD subfamily. PRKD3 / PRKCN contains one PH domain, two phorbol-ester/DAG-type zinc fingers and one protein kinase domain. Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second ... |
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TMPH-01263
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PRKN Protein, Human, Recombinant (His & SUMO)
PRKN,Parkin RBR E3 ubiquitin-protein ligase,E3 ubiquitin-pro...
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Human
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E. coli
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Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2. Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or det... |
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