36
11
6
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T70841 |
Osteosarcoma-IN-D14
|
Others | Others |
Osteosarcoma-IN-D14 is an inhibitor of migration and invasion of osteosarcoma cells mediated by p53, regulating EMT-related genes. | |||
T21876 |
DC_AC50
|
Apoptosis; Others | Apoptosis; Others |
DC_AC50 是一种 Atox 和 CCS 的双抑制剂,是一种抑制细胞内铜伴侣作为减少/预防获得性化疗耐药性的手段。它与 Atox1 和 CCS 结合并减少癌细胞增殖和肿瘤生长。 | |||
T70839 |
S 14063
|
Others | Others |
S 14063 is a potent 5-HT1A receptor antagonist devoid of beta-adrenoceptor blocking properties. | |||
T9102 |
WM-3835
|
Apoptosis; Histone Methyltransferase; Histone Acetyltransferase | Apoptosis; Chromatin/Epigenetic |
WM-3835 是一种高特异性 HBO1(KAT7orMYST2) 抑制剂,可直接与 HBO1 33 的乙酰辅酶 A 结合位点结合 WM-3835 激活细胞凋亡,抑制骨肉瘤细胞的增殖,迁移和侵袭。它抑制小鼠中骨肉瘤异种移植物的生长,有抗肿瘤活性。 | |||
T14364 |
AZ-Dyrk1B-33
3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine |
DYRK | Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors |
AZ-Dyrk1B-33 (3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine) 是高选择性的Dyrk1B 激酶抑制剂,其IC50=7 nM。 | |||
T77448 |
Naxitamab
Naxitamab-gqgk,Humanized 3F8,Hu3F8 |
Others | Others |
Naxitamab (Hu3F8) 是一种针对二氮冈糖苷 GD2 (hu3F8)的人源化单克隆抗体。Naxitamab 具有抗肿瘤活性,可用于研究神经母细胞瘤、骨肉瘤和其他 GD2 阳性癌症。 | |||
T13174 |
TMPyP4 tosylate
TMP 1363 |
DNA/RNA Synthesis; Telomerase | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
TMPyP4 tosylate (TMP 1363) 是四链体 (G-quadruplex) 的特异性配体,抑制四链体和 IGF-1 之间的相互作用。它也是端粒酶抑制剂,在骨肉瘤细胞系中显示抗肿瘤作用。 | |||
T0484 |
Deracoxib
SC 46,SC 046,地拉考昔,SC 59046 |
Apoptosis; COX | Apoptosis; Immunology/Inflammation; Neuroscience |
Deracoxib (SC 46) 是非甾体、非麻醉性抗炎药。 它也是选择性 cyclooxygenase-2 抑制剂,IC50 值:70 至 150 μM,抑制 3 种骨肉瘤细胞系。 | |||
T60039 |
KSQ-4279
USP1-IN-1 |
PARP; DUB | Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Ubiquitination |
KSQ-4279 (USP1-IN-1)是 USP1 和 PARP 的抑制剂。KSQ-4279 具有抗癌活性,可用于研究非小细胞肺癌、骨肉瘤、卵巢癌、乳腺癌、胶质母细胞瘤、膀胱癌、子宫癌和胰腺癌。 | |||
T37824 |
MSC-4381
MCT4-IN-1,MSC 4381,MSC4381 |
Monocarboxylate transporter | Membrane transporter/Ion channel |
MSC-4381 (MCT4-IN-1) 是一种可口服且具有选择性高效性的单羧酸转运蛋白 4 (MCT4/SLC16A3) 抑制剂,具有潜在的抗癌抗肿瘤活性,可用于研究骨肉瘤。 | |||
T26869 |
BMS-986122
BMS 986122 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
BMS-986122 (BMS 986122) 是选择性 μ 阿片受体正变构调节剂,可增加 β-抑制蛋白募集、腺苷酸环化酶抑制和 G 蛋白活化的作用,还增强 DAMGO 介导的 [35S]GTPγS 在小鼠脑膜中的结合。 | |||
T12037 |
Mifamurtide
L-MTP-PE,MTP-PE,CGP 19835,米伐木肽 |
Others | Others |
Mifamurtide is a drug against osteosarcoma, is an immunomodulator with antitumor effects. | |||
T26610 |
AM-6761
AM 6761,AM6761 |
Others | Others |
AM-6761 is a potent inhibitor of the MDM2-p53 interaction. In the SJSA-1 osteosarcoma xenograft model, AM-6761 shows excellent antitumor activity with an ED50 of 11 mg/kg. | |||
T35682 |
2-deoxy-2-fluoro-D-Glucose
|
Others | Others |
2-deoxy-2-fluoro-D-Glucose (2-FG) is a derivative of glucose with anticancer activity.1It inhibits the growth of 143B osteosarcoma cells grown under normoxic and hypoxic conditions when used at concentrations of 6 and 24 mM. | |||
T19559 |
Seocalcitol
EB 1089 |
Others | Others |
Seocalcitol is an analog of vitamin D, binds vitamin D receptor protein from human osteosarcoma MG-63 cells(Kd : 0.27 nM). | |||
T70983 |
Zoledronate disodium
|
Others | Others |
Zoledronate disodium is an inhibitor of osteoclastogenesis and macrophage recruitment, decreasing bone turnover and stabilizing the bone matrix, exhibiting diverse anti-tumor effects in osteosarcoma. | |||
TP2332L |
Mifamurtide sodium
Muramyl tripeptide,CGP 19835A,L-MTP-PE,米伐木肽钠盐,Mepact,Junovan |
||
Mifamurtide sodium is a drug against osteosarcoma, a kind of bone cancer mainly affecting children and young adults. It was approved in Europe in March 2009. | |||
T76377 |
Cdk2/Cyclin Inhibitory Peptide II
|
Others | Others |
Cdk2/Cyclin Inhibitory Peptide II (Tat-LDL) 是一种 CDK2抑制剂,能以剂量依赖的方式杀死 U2OS 骨肉瘤细胞。 | |||
T35408 |
(±)10(11)-EDP Ethanolamide
|
Others | Others |
(±)10(11)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 0.43 and 22.5 nM for CB1 and CB2 receptors, respectively). It is produced though direct epoxygenation of docosahexaenoyl ethanolamide by cytochrome P450 (CYP) epoxygenases. 10,11-EDP epoxide (12.5 and 25 μM) reduces the viability of 143B metastatic osteosarcoma cells. It induces apoptosis and inhibits cell migration in a wound-healing assay in 143B, MG63, and HOS osteosarcoma cells. (±)10(... | |||
T81353 |
Pterostilbene-isothiocyanate
PTER-ITC |
Others | Others |
Pterostilbene-isothiocyanate (PTER-ITC) 在体外展现出显著的抗癌活性。它通过干扰β-catenin/TCF-4的相互作用,从而针对人骨肉瘤细胞发挥作用。 | |||
T60975 |
Antitumor agent-50
|
Others | Others |
Antitumor agent-50 (compound 1a) 是一种噻唑烷酮。Antitumor agent-50 作为一种有效的抗肿瘤剂,在骨肉瘤 (OS)的研究中具有潜力。 | |||
T62480 |
Antitumor agent-51
|
Others | Others |
Antitumor agent-51 能够有效的、选择性的抑制骨肉瘤细胞的生长和迁移,作用于 MNNG/HOS 细胞 (IC50: 21.9 nM)。Antitumor agent-51 毒性较低,生物利用度极高。 | |||
TP2046 |
TAT-cyclo-CLLFVY
|
||
Selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50 = 1.3 μM). Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cance | |||
T62872 |
PDGFR-IN-1
|
Others | Others |
PDGFR-IN-1 (compound 7m) 是一种口服具有活力的 PDGFR (血小板源性生长因子受体) 抑制剂,作用于 PDGFRα (IC50: 2.4 nM) 和 PDGFRβ (IC50: 0.9 nM)。。PDGFR-IN-1 表现出较强的抗肿瘤作用,并毒性较低,能够用于研究骨肉瘤。 | |||
T35683 |
2-deoxy-D-Glucose-13C6
2-deoxy-D-Glucose-13C6 |
Others | Others |
2-deoxy-D-Glucose-13C6is intended for use as an internal standard for the quantification of 2-deoxy-D-glucose by GC- or LC-MS. 2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis.1,2It inhibits hexokinase, the enzyme that converts glucose to glucose-6-phosphate, as well as phosphoglucose isomerase, the enzyme that converts glucose-6-phosphate to fructose-6-phosphate.32-deoxy-D-Glucose (16 mM) induces apoptosis in SK-BR-3 cells, as well as inhibits the growth of 143B oste... | |||
T76759 | Robatumumab | ||
Robatumumab (Sch 717454) 为针对人胰岛素样生长因子 1 受体(anti-humanIGF-1R)的抗体,展现出抗肿瘤及阻止癌细胞增殖的作用,适用于骨肉瘤与尤文肉瘤的研究。 | |||
T68511 |
KRH102140
|
Others | Others |
KRH102140 is a potent activator of PHD2. KRH102140, which has a structure similar to KRH102053. KRH102140 more efficiently suppressed HIF-1α than KRH102053 in human osteosarcoma cells under hypoxia. Furthermore, KRH102140 decreased the mRNA levels of HIF-regulated downstream target genes associated with angiogenesis and energy metabolism such as vascular endothelial growth factor, adrenomedullin, Glut1, aldolase A, enolase 1 and monocarboxylate transporter 4. KRH102140 also inhibited tube format... | |||
T82327 |
GEM–IB
|
Others | Others |
GEM–IB是一种由吉西他滨(GEM)-5'-磷酸与伊班膦酸盐(IB)组成的复合物。在小鼠骨肉瘤(OS)模型中,GEM–IB能够作为独立活性分子减轻肿瘤负担,并在与多西紫杉醇(DTX)联合使用时,能进一步保护骨结构并提高生存率。 | |||
T76997 |
Socazolimab
|
||
Socazolimab (ZKAB001) 是一种针对PD-L1的单克隆抗体,在治疗复发或转移性宫颈癌方面展现了持久的安全性和有效性。此外,Socazolimab 也被认为在小细胞肺癌、食管鳞状细胞癌 (ESCC)、晚期尿路上皮癌及骨肉瘤治疗中具有潜在应用价值。 | |||
T74089 |
Mifamurtide TFA
|
Others | Others |
Mifamurtide TFA (MTP-PE TFA) 是穆拉基二肽 (MDP) 的类似物,一种非特异性免疫调节剂,通过刺激激活巨噬细胞和单核细胞的免疫应答而发挥作用。Mifamurtide TFA 是一种孤儿药,是 NOD2的特异性配体,用作胰岛素增敏剂。Mifamurtide TFA 具有用于骨肉瘤研究的潜力。 | |||
T36108 |
YW3-56 (hydrochloride) (technical grade)
YW3-56 (hydrochloride) (technical grade) |
Others | Others |
YW3-56 is an inhibitor of protein arginine deiminase 2 (PAD2) and PAD4 (IC50s = 0.5-1 and 1-5 μM, respectively).1It inhibits the growth of U2OS osteosarcoma cells (IC50= ~2.5 μM) in a p53-dependent mannerviainduction of SESN2 and subsequent inhibition of mTORC1. YW3-56 (10 mg/kg) reduces tumor growth in an S-180 murine sarcoma tumor model. It also inhibits tumor growth in the 1883 MDA-MB-231 breast cancer bone metastasis mouse xenograft model.2 1.Wang, Y., Li, P., Wang, S., et al.Anticancer pept... | |||
TP2046L |
TAT-cyclo-CLLFVY acetate(1446322-66-2 Free base)
|
||
TAT-cyclo-CLLFVY acetate(1446322-66-2 Free base) 是一种选择性 HIF-1 二聚化抑制剂。 TAT-cyclo-CLLFVY acetate 阻断重组 HIF-1α 与 HIF-1β 的蛋白质-蛋白质相互作用,但不阻断 HIF-2α 与 HIF-1β (IC50 = 1.3 μM)。 TAT-cyclo-CLLFVY acetate 在体外抑制缺氧诱导的 HIF-1 活性,并降低骨肉瘤和乳腺癌细胞中 VEGF 和 CAIX 的表达。 TAT-cyclo-CLLFVY acetate 减少缺氧 HUVEC 的管状化。 | |||
T35468 |
(±)19(20)-EDP Ethanolamide
|
Others | Others |
(±)19(20)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively). It is produced through direct epoxygenation of docosahexaenoyl ethanolamide by cytochrome P450 (CYP) epoxygenases. (±)19(20)-EDP ethanolamide (25 μM) reduces the viability of 143B metastatic osteosarcoma cells. It decreases the production of IL-6 and increases the production of IL-10 when used at concentrations ranging from 2.5 to 10 μM in BV-... | |||
T83854 |
BRC4wt TFA
|
||
BRC4wt是一种从人类BRCA2的BRC4重复区(1521-1536)衍生而来的乙酰化肽,并且是BRCA2与RAD51之间的蛋白质-蛋白质相互作用的抑制剂。当与阳离子穿膜肽(Arg)9结合时,BRC4wt缩短了体外DNA复制轨迹长度,并降低了由DNA拓扑异构酶I抑制剂坎普特西汀引起的DNA损伤的同源修复频率,同时也增强了聚(ADP-核糖)聚合酶(PARP)抑制剂奥拉帕尼在HeLa人类宫颈癌细胞和U2OS人类骨肉瘤细胞中诱导的细胞死亡,但在非癌症细胞hTERT RPE-1、MRC-5或MCF-10A中则不然。 | |||
T83911 |
CYY292
|
Others | Others |
CYY292是一种针对PDGFRα、PDGFRβ、FGFR1、-2和-3的抑制剂(IC50分别为5.35、4.6、28、28和78 nM)。该化合物对这些激酶的选择性高于FGFR4(IC50 > 1,000 nM),但也能抑制c-Kit、VEGFR2、VEGFR1和胰岛素样生长因子1受体(IGF-1R;IC50分别为67、33、36和75 nM),以及EGFR、布鲁顿酪氨酸激酶(BTK)、细胞周期依赖性激酶4(Cdk4)/cyclin D3和MET(IC50分别为128、198、214和396 nM)。CYY292抑制MG-63、U2OS、MNNG/HOS和Saos-2骨肉瘤细胞的增殖(IC50分别为0.84、0.76、1.36和0.72 µM)。在0.3和0.5 µM的浓度下,它抑制U87MG和LN-229胶质母细胞瘤细胞的迁移和侵袭。CYY292(30 mg/kg)在U87MG原位小鼠异种移植模型中降低肿瘤体积并增加生存率。 | |||
T35604 |
Osteocalcin (1-49) (human) (trifluoroacetate salt)
|
||
Osteocalcin (1-49) is a non-collagenous peptide that is secreted by osteoblasts and odontoblasts and comprises 1-2% of the total protein in bone. Secretion of osteocalcin (1-49) is stimulated by 1,25-dihydroxy vitamin D and plasma levels increase in diseases that induce dysregulated bone turnover such as osteoporosis, Paget's disease, and primary hyperparathyroidism. Osteocalcin (1-49) is positively correlated with insulin sensitivity and negatively correlated with high blood glucose levels in w... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3878 |
Raddeanin A
NSC382873,竹节香附素A,Anemodeanin A,Raddeanin R3 |
Apoptosis; HDAC | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair |
Raddeanin A (NSC-382873) 是竹节香附中的一种天然三萜皂苷,可抑制组蛋白去乙酰化酶,具有很强的抗血管生成能力和抗肿瘤活性。 | |||
T5S0803 |
Columbamine
非洲防己碱,Columbamin,Dehydroisocorypalmine |
Others | Others |
Columbamine (Columbamin) 是一种从植物中提取的季异喹啉生物碱。 | |||
T3425 |
Polyphyllin G
重楼皂苷VII,Polyphyllin VII,Polyphyllin VII,Y-0166,重楼皂苷G |
Others | Others |
Polyphyllin G (Polyphyllin VII) 是从Paris yunnanensis 的根茎中分离出来的,具有抗菌活性,抑制革兰氏阳性和革兰氏阴性细菌的生长。它是polyphyllin 家族的主要成员,对肺癌、乳腺癌、结直肠癌、宫颈癌、肝细胞癌和骨肉瘤等多种癌症具有很强的抗癌活性。 | |||
T5S0053 |
Coptisine
黄连碱,Coptisin |
Indoleamine 2,3-Dioxygenase (IDO) | Metabolism |
Coptisine (Coptisin) 是一种从黄连中分离到的生物碱,是非竞争性的IDO 抑制剂,Ki=为 5.8 μM,IC50=6.3 μM。 | |||
T4S1335 |
Daphnoretin
Dephnoretin,西瑞香素,Thymelol |
Influenza Virus; Caspase; PKC | Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology; Proteases/Proteasome |
Daphnoretin (Thymelol) 是从了哥王中提取得到的一种天然产物,具有抗癌和抗病毒活性。它通过在 G2/M 期连续阻断细胞并激活 caspase-3 通路导致 HOS 细胞死亡。 | |||
T2S1837 |
Steviol
甜菊醇,NSC 226902,Hydroxydehydrostevic acid |
Others | Others |
Steviol (NSC-226902) 是一种甜菊糖甙的主要代谢物。它能降低 AQP2 的表达,并促进 AQP2 的降解,从而减缓肾囊肿的生长。 | |||
T6S1141 |
Ganoderic acid A
灵芝酸 A,灵芝酸A |
Apoptosis; NF-κB; Endogenous Metabolite; Autophagy | Apoptosis; Autophagy; Metabolism; NF-κB |
Ganoderic acid A 能够抑制 JAK-STAT3信号通路,也能抑制细胞增殖,存活率和 ROS。 它对人骨肉瘤 HOS 和MG-63细胞具有增殖抑制、凋亡和侵袭抑制作用。 | |||
T3923 |
Calycosin
Cyclosin,3'-Hydroxyformononetin,异黄酮,毛异黄酮 |
Apoptosis; Tyrosinase | Apoptosis; Proteases/Proteasome |
Calycosin (Cyclosin) 是一抗氧化和抗炎症活性天然产物。 | |||
TN4637 |
Neogrifolin
|
PARP; GSK-3; Akt; Caspase | Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells |
Neogrifolin is a potential candidate for osteosarcoma, it can induce concentration- and time-dependent suppression of proliferation and induce apoptosis in U2OS and MG63 osteosarcoma cell lines; it exhibits inhibitory activity against nitric oxide (NO) production stimulated by lipopolysaccharide (LPS) in RAW 264.7 cells with the IC50value of 23.3 microM. Neogrifolin possesses antimicrobial activities against Bacillus cereus and Enterococcus faecalis, the MIC values of 20 and 0.5 microg/mL, respe... | |||
TN6419 | Chamaejasmine | ||
Chamaejasmine could be a candidate drug for osteosarcoma and breast cancer chemoprevention, induces apoptosis in MG63 and HEp-2 cells by Akt inactivation and dephosphorylation of BAD. It inhibits Bcl-2 expression and induces Bax expression to desintegrate | |||
TN3587 |
Capillarisin
|
MMP; ERK; IL Receptor; BCL; VEGFR; TNF; NOS; NF-κB; TLR; MAPK; COX; DNA/RNA Synthesis; Prostaglandin Receptor; JNK; STAT | Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; MAPK; Neuroscience; NF-κB; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors |
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cells, it inhibits cancer cell growth of osteosarcoma cells by inducing apoptosis accompanied with |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-03978 |
TSPAN31 Protein, Human, Recombinant (mFc)
tetraspanin 31,SAS |
Human | HEK293 Cells |
TSPAN31 is a member of the transmembrane 4 superfamily. Most members of this family are cell-surface proteins that are characterized by the presence of four hydrophobic domains. They mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TSPAN31 is thought to be involved in growth-related cellular processes. This gene is associated with tumorigenesis and osteosarcoma. | |||
TMPJ-00799 |
ANXA2 Protein, Human, Recombinant
ANXA2,Calpactin I Heavy Chain,ANX2,p36,LPC2D,PAP-IV,ANX2L4,C... |
Human | E. coli |
Annexin A2 (ANXA2) is a member of the annexin family and has roles in the regulation of cellular growth and in signal transduction pathways. ANXA2 protein is associated with sickle cell osteonecrosis and the expression reduce of ANXA2 is associated with osteosarcoma metastases. ANXA2 functions as an autocrine factor, it can increases osteoclast formation and bone resorption. ANXA2 is involved in muscular dystrophies. In humans, the up-regulation of ANXA2 is related with colon adenocarcinoma cell... | |||
TMPJ-00561 |
SDC2 Protein, Human, Recombinant (His)
CD362,SDC2,HSPG,HSPG1,Syndecan-2,SYND2,Heparan Sulfate Prote... |
Human | HEK293 Cells |
Syndecan-2 is a member of the Syndecans family comprised of type I transmembrane heparan sulfate proteoglycans (HSPG) that are involved in the regulation of many cellular processes. Four sub-types of mammalian Syndecans have been reported and among them. Syndecan-2 plays a role in the cancer development. It can affect the basal and chemotherapy-induced apoptosis in osteosarcoma. It can also suppress MMP2 activation, suppressing metastasis. | |||
TMPJ-00692 |
GAS7 Protein, Human, Recombinant (His)
GAS-7,GAS7,Growth Arrest-Specific Protein 7,KIAA0394 |
Human | E. coli |
Growth Arrest-Specific Protein 7 (GAS7) is expressed primarily in terminalaly differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 may play a role in neuronal development by promoting maturation and morphological differentiation of cerebellar neurons. Inhibition of GAS7 production in terminally differentiating cultures of embryonic murine cerebullum impedes neurite outgrowth. The hyper-expression of GAS7 may play an major role in the initiation and development... | |||
TMPY-03046 |
APCDD1 Protein, Human, Recombinant (hFc)
HYPT1,B7323,adenomatosis polyposis coli down-regulated 1,HTS... |
Human | HEK293 Cells |
Osteosarcoma (OS) is the most common type of bone tumor in children and adults. The expression of APCDD1, a Wnt antagonist, was reduced in OS tissues and cells compared to adjacent normal tissue and osteoblast cells, respectively. Mechanistically, this was due to increased levels of methylation in the promoter region of the APCDD1 gene. Consistently, the DNA methyltransferase inhibitor 5-AZA-dC, reduced DNA methylation in the APCDD1 promoter, and restored APCDD1 expression in OS tissue and cells... | |||
TMPJ-00164 |
IGFBP-5 Protein, Human, Recombinant (His & Avi), Biotinylated
IBP-5,IBP5,IGF-Binding Protein 5,IGFBP5,Insulin-Like Growth ... |
Human | HEK293 Cells |
Insulin-Like Growth Factor-Binding Protein 5 (IGFBP-5) is a secreted protein that belongs to the insulin-like growth factor (IGF) binding proteins superfamily. Members of this family prolong the half-life of the IGFs. They have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. IGFBP-5 contains one IGFBP N-terminal domain and one thyroglobulin type-1 domain. IGFBP-5 is expressed... |