59
7
3
42
4
Cat. No. | Product Name | ||
---|---|---|---|
L2630 | 神经元分化化合物库 | 672 compounds | |
672 种与神经元分化相关的化合物,可以用于神经系统疾病药物研发 | |||
L2600 | 神经信号分子库 | 2540 compounds | |
2540 种CNS 相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L2700 | 肾上腺素能受体化合物库 | 193 compounds | |
193 种特异靶向肾上腺素受体的生物活性小分子化合物的集合,是相关疾病药物筛选的有效工具; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T35878 |
N-(3-Aminopropyl)cyclohexylamine
|
Others | Others |
N-(3-Aminopropyl)cyclohexylamine, a derivative of cyclohexylamine, functions as a selective and competitive inhibitor of spermine synthase, making it suitable for research on neurological diseases[1]. | |||
T6822 |
Hydroxy-Dynasore
Dyngo-4a |
Dynamin | Cytoskeletal Signaling |
Hydroxy-Dynasore (Dyngo-4a) 是 Dynasore 结构模拟类似物,是一种改进的,低细胞毒性的 dynamin 通用抑制剂,抑制 dynamin 依赖性转铁蛋白的内吞作用的 IC50为 5.7 μM,对大脑重组 dynamin I 和重组鼠 dynamin II 的 IC50值分别为 0.38 μM 和 2.3μM。 | |||
T23498 |
UNC3230
UNC 3230 |
Others | Others |
UNC3230 是一种 ATP 竞争性的磷脂酰肌醇 4 磷酸 5 激酶 1C 型 (PIP5K1C) 选择性抑制剂,其IC50约为 41 nM。它还可抑制PIP4K2C,但对其他调节磷酸肌醇水平的脂质激酶无抑制作用。它具有缓解疼痛和抗癌特性。 | |||
T14989 |
CMPD101
|
ROCK; GRK; PKC | Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; GPCR/G Protein; Stem Cells |
CMPD101 是膜透性的 GRK2/3高选择性小分子抑制剂,IC50分别为 18 nM 和 5.4 nM。它针对 GRK1、GRK5 ROCK-2 和 PKCα 的选择性较小,IC50值分别为 3.1 μM,2.3 μM,1.4 μM 和 8.1 μM,可研究心衰疾病。 | |||
T4993 |
Afloqualone
氟喹酮,HQ-495 |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Afloqualone (HQ-495) 是一种 GABA 受体激动剂。靶点:体外 GABA 受体:Afloqualone 是一种喹唑啉酮家族 GABA 能药物。由于其在 GABAa 受体β亚型的激动剂活性,它具有镇静和肌肉松弛作用。 | |||
T7748 |
Dermorphin TFA
皮啡肽三氟乙酸盐 |
Others; Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience; Others |
Dermorphin TFA 是在两栖类皮肤中发现的天然七肽,是 μ-阿片受体激动剂,可用于抑制神经痛。 | |||
T4641 |
Branaplam
LMI 070,NVS-SM1 |
Others; Potassium Channel; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Others |
Branaplam (LMI 070) 是一种高效、选择性和口服活性的小分子 SMN2 剪接调节剂,对 SMN 的 EC50为 20 nM。它可提高全长 SMN 蛋白并延长其生存期,也抑制 hERG,IC50为 6.3 μM。 | |||
T3217 |
PF-CBP1 hydrochloride
PF-CBP1 HCl |
Epigenetic Reader Domain; Histone Acetyltransferase | Chromatin/Epigenetic |
PF-CBP1 hydrochloride (PF-CBP1 HCl) 是 CREB 结合蛋白溴结构域的一种高选择性抑制剂,抑制 CREBBP 和 EP300溴结构域的 IC50分别为 125 和 363 nM。它降低 LPS 诱导的巨噬细胞中炎症因子的表达,也可下调皮质神经元 RGS4 的表达,可用于癫痫和帕金森病等神经疾病的研究。 | |||
T2141 |
Mecamylamine hydrochloride
盐酸美加明,Inversine,Mevasin |
AChR | Neuroscience |
Mecamylamine hydrochloride (Mevasin) 是一种易穿过血脑屏障的烟碱拮抗剂,用作高血压的神经节阻滞剂,具有抗神经疾病作用。 | |||
T22517 |
5,7-Dichlorokynurenic acid
5,7-二氯犬尿喹啉酸,5,7-dichlorokynurenic acid sodium,5,7-DCKA |
NMDAR | Neuroscience |
5,7-Dichlorokynurenic acid (5,7-dichlorokynurenic acid sodium) 是一种专门针对于NMDA 受体甘氨酸位点的竞争性拮抗剂(KB:65 nM)。它是犬尿酸的衍生物,可降低大鼠皮质细胞培养物中 NMDA 诱导的神经元损伤程度。 | |||
TQ0157 |
EIPA
L593754,MH 12-43 |
Sodium Channel; TRP/TRPV Channel | Membrane transporter/Ion channel |
EIPA (L593754) 是一种有效的TRPP3 channel 抑制剂,IC50为 10.5 μM。EIPA 对Na+/H+交换 (NHE) 和巨噬细胞也有抑制作用。 | |||
TP2045 |
CH 275
|
||
Potent somatostatin receptor 1 (sst1) agonist; displays selectivity for sst1 (IC50 values are 30.9 nM, 345 nM, > 1 μM, > 10 μM and > 10μM for human sst1, sst3, sst4, sst2 and sst5 respectively). Attenuates somatostatin release in the rat nucleus accumbens | |||
T7404 |
Dermorphin
皮啡肽 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Dermorphin 是在两栖类皮肤中发现的天然七肽,是 μ-阿片受体激动剂,可用于抑制神经痛。 | |||
TP1827L |
Neuronostatin-13 human acetate
Neuronostatin-13 human acetate(1096485-24-3 free base) |
Others | Others |
Neuronostatin-13 human acetate(1096485-24-3 free base) 是一种 13 个氨基酸的肽类激素,在调节激素和心脏功能中起重要作用。 | |||
T60750 |
Neuronotoxicity-IN-1
|
Others | Others |
Neuronotoxicity-IN-1 是一种吡啶并噻嗪衍生物。Neuronotoxicity-IN-1 具有神经保护活性,是红藻氨酸神经毒性的抑制剂。 | |||
TP1827 |
Neuronostatin-13 (human)
Neuronostatin-13 human |
||
Neuronostatin-13 (Human) is a 13 amino acid residue peptide with carboxyl-terminal amidation, the primary structure is conserved in human chimpanzee and some other mammals. | |||
TP1852L |
Myomodulin acetate(110570-93-9 free base)
|
Potassium Channel; Calcium Channel; Sodium Channel | Membrane transporter/Ion channel; Metabolism |
Myomodulin acetate(110570-93-9 free base) 存在于两个已识别的海兔神经元中,它们包含肌调节蛋白 A、ARC 运动神经元 B16 和腹部神经元 L10。 | |||
T23446 |
TCS 2210
|
Others | Others |
TCS 2210是间充质干细胞中神经元分化的诱导剂,并增加神经元标志物β-III 管蛋白的表达和神经元特异性烯醇酶的表达。 | |||
T27084 |
Crisdesalazine
AAD2004,AAD 2004,AAD-2004 |
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Crisdesalazine (AAD 2004) 是微粒体前列腺素 E2 合酶 1 (mPGES-1) 的抑制剂。 Crisdesalazine 可减少自噬体形成、轴索病变和运动神经元变性,改善运动功能并延长寿命。 | |||
T3525 |
PD150606
|
Cysteine Protease | Proteases/Proteasome |
PD150606 是一种具有选择性的非肽 calpain 抑制剂,具有神经保护活性,抑制 μ-calpains 和 m-calpains ,抑制红藻氨酸诱导的 Ca2+ 内流,干扰兴奋性毒性依赖性运动神经元死亡。 | |||
T16757 |
Risdiplam
RO7034067,RG7916 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Risdiplam (RO7034067) 是一种中枢和外周分布的 SMN2 前 mRNA 剪接修饰剂,可增加运动神经元存活 (SMN) 蛋白水平。 | |||
T2003 |
ISX-9
Isoxazole 9,Isoxazole 9 (ISX-9) |
Calcium Channel; Wnt/beta-catenin | Cytoskeletal Signaling; Membrane transporter/Ion channel; Metabolism; Stem Cells |
ISX-9 (Isoxazole 9) 是一种神经干细胞分化的有效诱导剂,可诱导 Notch 激活的心外膜衍生细胞(NEC) 的心肌分化。它可通过电压门控的 Ca2+通道和 NMDA 受体来激活 Ca2+流入,并增加 NeuroD 表达。 | |||
T2663 |
GTS-21 dihydrochloride
GTS 21 dihydrochloride,DMXB-A,DMBX-anabaseine |
5-HT Receptor; AChR | GPCR/G Protein; Neuroscience |
GTS-21 dihydrochloride (DMBX-anabaseine) 是一种选择性 α7 烟碱乙酰胆碱受体激动剂,具有抗炎和增强认知的活性。它也是一种拮抗剂,对人α4β2的 Ki 为20 nM,对5-HT3A 受体的 IC50为3.1 μM。 | |||
T5444 |
CLP290
CLP-290 |
Potassium Channel | Membrane transporter/Ion channel |
CLP-290 是一种神经特异性 K+-Cl−共转运体 KCC2的口服激活剂,在多种神经和精神疾病方面具有研究潜力。CLP290 能显著降低 STZ 大鼠的血液中 AVP 和血糖水平。 | |||
T27794 |
λ-Cyhalothrin
lambda-Cyhalothrin,Karate,λ-氯氟氰菊酯,Icon |
Sodium Channel; Parasite | Membrane transporter/Ion channel; Microbiology/Virology |
λ-Cyhalothrin (Icon) 是广谱的 II 型合成除虫菊酯杀虫剂,含有 α-氰基,用于防治多种害虫。它是一种钠通道神经毒素,靶向中枢神经系统中神经元膜。 | |||
T4431 |
Olodanrigan
PD-126055,EMA401 |
RAAS | Endocrinology/Hormones |
Olodanrigan (EMA401) 是具有口服活性、高选择性及外周受限的血管紧张素 Ⅱ 类型 2 受体(AT2R)拮抗剂。它的缓解疼痛的机制可能是:抑制增强的 AngII/AT2R 诱导的 p38 和 p42/p44 MAPK 激活,进而阻碍 DRG 神经元的过度兴奋性及 DRG 神经元的萌发。它可用于研究神经性疼痛。 | |||
T23709 |
alphaSYN-IN-NAB2
alphaSYN inhibitor NAB2,alphaSYNINNAB2,alphaSYN-IN-NAB2,NAB2,alphaSYN inhibitor-NAB2 |
Others | Others |
alphaSYN-IN-NAB2 是一种神经元保护剂,是一种由 NAB2基因编码的蛋白质。NAB2 高效且具有选择性地保护多种细胞免受 α-syn 毒性。NAB2 对依赖于 E3 泛素连接酶 Rsp5/Nedd4 的内体转运具有促进作用。NAB2 确定 α-syn 生物学中的一个可活性分子节点,该节点可以纠正其潜在病理学的多个方面,包括功能失调的内体和内质网到高尔基体囊泡的运输。NAB2参与细胞分化、凋亡和应激反应等细胞过程,可用来研究癌症、神经发育和神经元活动。 | |||
T24450 |
Mephenoxalone
Lenetran Lenetran,TAB Lenetranat |
Others | Others |
Mephenoxalone is a muscle relaxant and mild anxiolytic. It inhibits neuron transmission and relaxing skeletal muscles by inhibiting the reflex arc. | |||
T33858 |
PACA
N-Propargyl Caffeamide |
Others | Others |
PACA, (N-propargyl Caffeamide)enhances NGF-induced neurite growth and reduces 6-hydroxydopamine neurotoxicity in neuron cultures. Parkinson's disease (PD) is associated with insufficient production of nerve growth factor (NGF). | |||
TP1852 |
Myomodulin
肌调蛋白 |
Others; Potassium Channel; Calcium Channel; Sodium Channel | Membrane transporter/Ion channel; Metabolism; Others |
Myomodulin 是一种存在于软体动物、昆虫和腹足类动物中的神经肽。它存在于两个已确定的海兔神经元中,它们包含肌调节蛋白 A、ARC 运动神经元 B16 和腹部神经元 L10。 | |||
T34664 |
SMN2-Stablizer-27
SMN2-Stablizer 27,SMN2 Stablizer-27 |
Others | Others |
SMN2-Stablizer-27 is a stablizer of survival of motor neuron 2 (SMN2), and a post-translationally stablizing SMN protein for the treatment of spinal muscular atrophy (SMA). | |||
T13071 |
Talsaclidine
|
Others | Others |
Talsaclidine is an agonist of muscarinic with preferential neuron-stimulating properties. Talsaclidine is a full agonist at the M1 subtype, and as a partial agonist at the M2 and M3 subtypes. | |||
T31187 |
Dactylorhin B
|
Others | Others |
Dactylorhin B is an active compound isolated from Coeloglossum Viride. Dactylorhin B reduces the toxic effects of β -amyloid fragments (25-35) on neuron cells and isolated rat brain mitochondria, which play an important role in neurodegenerative diseases. | |||
T37748 |
Ivermectin B1b
|
Others | Others |
Ivermectin B1b is the minor component . It produces antiparasitic activity by binding to glutamate-gated chloride channels expressed on nematode neurons and pharyngeal muscle cells, inducing irreversible channel opening and very long-lasting hyperpolarization/depolarization of the neuron/muscle cell, thereby blocking further function. | |||
T29000 |
Tralomethrin
EPA Pesticide Chemical Code 121501,SAGA,HAG-107,HAG 107,Scout |
Others | Others |
Tralomethrin is used as a pyrethroid insecticide. It modifies the gating kinetics of the sodium channels in neurons, increases the length of time the channel remains open after a stimulus, thereby depolarizing the neuron for a longer period of time. This leads to uncontrolled spasms, paralysis, and eventual death. | |||
T35608 |
16F16
|
Others | Others |
16F16 is a protein disulfide isomerase (PDI) inhibitor.1It inhibits PDI reductase activity in an enzyme assay when used at concentrations ranging from 1 to 100 μg/ml.116F16 reduces PC12 cell apoptosis induced by the misfolded huntingtin protein HTTQ103. It suppresses PDI-dependent mitochondrial outer membrane permeabilization (MOMP) in isolated PC12 cell mitochondria. 16F16 (2, 3, 4, and 10 μM) reduces HTTN90Q73mutant huntingtin-induced medium spinal neuron death and MOMP in rat corticostriatal ... | |||
T84691 |
1R-cis-Permethrin
1R-cis-NRDC-143,顺式苄氯菊二丙酯 |
Others | Others |
1R-cis-Permethrin为一种杀虫剂以及神经毒素,主要通过延长钠通道激活来影响神经元膜。 | |||
T38656 |
Nusinersen
|
Others | Others |
Nusinersen is an antisense oligonucleotide drug that modifies pre–messenger RNA splicing of the SMN2 gene and thus promotes increased production of full-length SMN protein. | |||
T84560 |
Prostaglandin A1
PGA1 |
Others | Others |
Prostaglandin A1,Prostaglandin E1的脱水衍生物,具有抑制肿瘤生长、炎症、病毒复制、血小板聚集以及神经毒素诱导的神经元凋亡(apoptosis)的作用。 | |||
T69921 |
BRF110
|
Others | Others |
BRF110 is a brain penetrant, potent and selective agonist of nuclear receptor-related 1 (Nurr1):Retinoid X receptor α (RXRα) heterodimer. BRF110 is a neuroprotective agent that prevents dopaminergic neuron demise and striatal dopaminergic denervation in vivo against PD-causing toxins. It induced dopamine biosynthesis in vivo. BRF110 chronic dosing does not induce dyskinesia in mice model. | |||
TP2215 |
Agouti-related Protein (AGRP) (25-82), human
|
Others | Others |
Agouti-related peptide (AgRP) is a neuropeptide produced in the brain by the AgRP/NPY neuron. It is only synthesized in NPY containing cell bodies located in the ventromedial part of the arcuate nucleus in the hypothalamus. The appetite-stimulating effect | |||
T8443L |
MCI-225 hydrochloride hydrate
AA-10021,AA10021,MCI225,DDP-225,AA-10025,AA-10026 |
Others | Others |
MCI-225 is a norepinephrine reuptake/5-HT3/5-HT reuptake inhibitor. MCI-225 could be effective in the treatment of senile dementia of the Alzheimer type, which is accompanied with both deficit in the BF-cortex cholinergic neuron and cerebral glucose hypom | |||
T83512 |
[1,6-Aminosuberic acid]-arginine-Vasotocin
|
||
[1,6-Aminosuberic acid]-arginine-Vasotocin,一种类似神经垂体激素的合成肽,对黄芪周期性振荡神经元(PON)展现兴奋作用。 | |||
T76484 |
[Tyr8,Nle11] Substance P
|
||
[Tyr8,Nle11] Substance P 是 Substance P 的类似物。Substance P 是一种主要由神经元分泌的肽,参与许多生物学过程,包括痛觉和炎症。 | |||
T68714 |
Iobenguane I 131
|
Others | Others |
Iobenguane I 131 is a guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used as antineoplastic agents and radioactive imaging agents. MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase. | |||
T14693 |
BN201
|
Others | Others |
BN201 is able to cross the blood-brain barrier by active transport and activate pathways (IGF-1 pathway) associated with the response to stress and neuron survival. BN201 promotes neuronal differentiation, the differentiation of precursor cells to mature | |||
T15455 |
RGH-5526
GYKI-11679 |
Others | Others |
RGH-5526是一种新型的抗高血压药。它引起下丘脑去甲肾上腺素(NA)周转(利用)增加,下丘脑去甲肾上腺素能神经元活性的增加可能导致外周交感神经活性的降低,从而显著降低血压。 | |||
T81974 |
KPZ560
|
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
KPZ560作为HDAC1和HDAC2的有效抑制剂,在IC50数值上分别达到12 nM 和68 nM 。此化合物能提升小鼠颗粒神经元树突的棘密度,同时也能抑制MCF乳腺癌细胞系的生长。 | |||
T81575 |
PA22-2 free acid
Cys-Laminin A chain 2091-2108 |
||
PA22-2 (free acid) (Cys-Laminin A chain 2091-2108) 为促进神经突生长和神经元样过程形成的多肽。该化合物适用于人腺样囊性癌细胞培养和肽功能化磷脂双层制备<sup>[3]。 | |||
T64082 |
ABC44
|
Others | Others |
ABC44 是丝氨酸水解酶 (serine hydrolase) 的有效抑制剂,对棕榈酰蛋白硫酯酶 1 (PPT1) 原位和体外的 IC50 分别为 0.1 μM 和 6.5 μM。ABC44 能够用于研究婴儿晚期神经元样脂褐质沉积症。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0508 |
γ-Aminobutyric acid
Gamma-aminobutyric acid,4-Aminobutyric acid,4-氨基丁酸,γ-氨基丁酸,GABA,4-Aminobutanoic acid,Piperidic acid |
GABA Receptor; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism; Neuroscience |
γ-Aminobutyric acid (4-Aminobutyric acid) 是成年哺乳动物大脑中主要的抑制性神经递质,能够与离子移变 GABA 受体(GABAA) 受体和促代谢受体 (GABAB) 受体结合发挥作用。 | |||
TN1494 |
Cimicifugoside H-1
黑升麻苷H-1 |
Others | Others |
Cimicifugoside H1 是C. foetidaL.C 提取物的主要成分,是一种环甾烷醇木糖苷。它对骨吸收及卵巢切除术引起的骨质流失具有抑制作用。 | |||
T4S2084 |
3'-Methoxypuerarin
3'-甲氧基葛根素,3’- Methoxy Puerarin |
Antioxidant | oxidation-reduction |
3'-Methoxypuerarin 是一种提取自葛根中的异黄酮,具有神经元保护作用。 | |||
T3836 |
Eudesmin
|
MAPK; S6 Kinase | MAPK; PI3K/Akt/mTOR signaling |
Eudesmin 通过抑制S6K1信号通路来干扰成脂分化,具有抗肿瘤、抗炎和抗菌活性。 | |||
T5S2357 |
Acetylcorynoline
(+)-Corynoline Acetate,O-Acetylcorynoline,乙酰紫堇灵 |
Antifungal | Microbiology/Virology |
Acetylcorynoline (O-Acetylcorynoline) 是提取自 Corydalis bungeana 中的一种主要生物碱成分,具有抗炎活性。 | |||
T8270 |
Deserpidine
地舍平,Harmonyl |
RAAS | Endocrinology/Hormones |
Deserpidine (Harmonyl) 是从 Rauwolfia canescens 的根中分离的生物碱。Deserpidine 与 Reserpine 相关。Deserpidine 是竞争性血管紧张素转化酶抑制剂,可以被用作抗高血压药以及镇定剂。Deserpidine 还减少了肾上腺皮质血管紧张素 II 诱导的醛固酮分泌。 | |||
T4752 |
1-Aminocyclopropane-1-carboxylic acid
1-Aminocyclopropanecarboxylic acid,1-氨基环丙烷羧酸,1-Amino-1-carboxycyclopropane,ACC |
Endogenous Metabolite; NMDAR | Metabolism; Neuroscience |
1-Aminocyclopropane-1-carboxylic acid (ACC) 是内源性代谢产物的一种。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-02920 |
SMN1 Protein, Mouse, Recombinant (His & Myc)
Survival motor neuron protein,Smn1 |
Mouse | HEK293 Cells |
SMN1 Protein, Mouse, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 35.3 kDa and the accession number is P97801. | |||
TMPY-03451 |
SPF30 Protein, Human, Recombinant (His)
SPF30,SMNR,TDRD16C,survival motor neuron domain con... |
Human | E. coli |
SMNDC1 gene is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. SMNDC1 is a nuclear protein that has been identified as a constituent of the spliceosome complex. SMNDC1 gene is differentially expressed, with abundant levels in skeletal muscle, and may share similar cellular function as the SMN1 gene. SMNDC1 is necessary for spliceosome assembly. Its overexpression causes apoptosis. | |||
TMPH-01845 |
PNMA1 Protein, Human, Recombinant (B2M & His & JD & Myc)
Neuron- and testis-specific protein 1,37 kDa ne... |
Human | E. coli |
PNMA1 Protein, Human, Recombinant (B2M & His & JD & Myc) is expressed in E. coli expression system with N-10xHis-B2M-JD and C-Myc tag. The predicted molecular weight is 46.8 kDa and the accession number is Q8ND90. | |||
TMPH-02806 |
Nav3 Protein, Mouse, Recombinant (His)
Neuron navigator 3,Pore membrane and/or filament-in... |
Mouse | E. coli |
May regulate IL2 production by T-cells. May be involved in neuron regeneration. | |||
TMPH-03754 |
NAV1 Protein, Human, Recombinant (His)
NAV1,Steerin-1,Pore membrane and/or filament-interacting-lik... |
Human | E. coli |
May be involved in neuronal migration. | |||
TMPH-02748 |
KCP Protein, Mouse, Recombinant (His & Myc)
Kcp,Cysteine-rich BMP regulator 2,Kielin/chordin-like protei... |
Mouse | E. coli |
Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways. KCP Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 44.7 kDa and the accession number is Q3U492. | |||
TMPH-00929 |
APBA2 Protein, Human, Recombinant (His & Myc)
Adapter protein X11beta,MINT2,Neuronal Munc18-1-int... |
Human | HEK293 Cells |
Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. APBA2 Protein, Human, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 87.5 kDa and the accession number is Q99767. | |||
TMPH-00928 |
APBA2 Protein, Human, Recombinant (E. coli, His & Myc)
Neuronal Munc18-1-interacting protein 2 (Mint-2),Am... |
Human | E. coli |
APBA2 Protein, Human, Recombinant (E. coli, His & Myc) is expressed in E. coli. | |||
TMPJ-00722 |
APBA3 Protein, Human, Recombinant (His)
Neuronal Munc18-1-Interacting Protein 3,Neuron<... |
Human | E. coli |
Amyloid β A4 Precursor Protein-Binding Family A Member 3 (APBA3) is an adapter protein that belongs to the X11 family. APBA3 contains 2 PDZ (DHR) domains and 1 PID domain and interacts with the Alzheimer's disease amyloid precursor protein.. APBA3 is believed to be involved in signal transduction processes. Unlike X11-α and -β which are generally neuronal proteins, APBA3 is widely expressed in all tissues examined with lower levels in brain and testis. It binds to the cytoplasmic domain of amylo... | |||
TMPY-02646 |
NSE/ENO2 Protein, Human, Recombinant (His)
enolase 2 (γ, neuronal),NSE,HEL-S-279,enolase 2 (ga... |
Human | E. coli |
The combination of silencing ENO2 and 2-deoxyglucose (2-DG) synergistically inhibited leukemia cell survival. ENO2 may be a biological marker for monitoring chemotherapeutic efficacy and relapse in ALL. Reduced ENO2 expression may be a biomarker for a subset of autistic children. Neuron specific enolase (ENO2, gamma-enolase) has been used as a biomarker to help identify neuroendocrine differentiation in breast cancer. | |||
TMPJ-00587 |
NRCAM Protein, Human, Recombinant (hFc)
gCAM-related cell adhesion molecule,hBravo,Ng-CAM-related,Nr... |
Human | HEK293 Cells |
Neuronal cell adhesion molecule(NRCAM) is a single-pass type I membrane protein ,containing 5 fibronectin type-III domains and 6 Ig-like C2-type (immunoglobulin-like) domains.It belongs to the immunoglobulin superfamily. NrCAM is engaged in such biological processes as axonal fasciculation, cell-cell adhesion, central nervous system development, clustering of voltage-gated sodium channels, neuron migration, positive regulation of neuron differentiation, regulation of axon extension, and synaptog... | |||
TMPH-03713 |
ELAVL4 Protein, Xenopus tropicalis, Recombinant (His)
ELAVL4,HuD,Hu-antigen D,ELAV-like protein 4,PNEM |
Xenopus tropicalis | E. coli |
RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs. Plays a role in the regulation of mRNA stability, alternative splicing and translation. Binds to AU-rich element (ARE) sequences in the 3' untranslated region (3'UTR) of target mRNAs. Mainly plays a role in neuron-specific RNA processing. | |||
TMPK-00541 |
SEZ6 Protein, Cynomolgus, Recombinant (His)
SEZ-6,BSRPC,BSRP-C,SEZ6 |
Cynomolgus | HEK293 Cells |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weig... | |||
TMPH-02228 |
TRA2B Protein, Human, Recombinant (His & Myc)
TRA2B,Transformer-2 protein homolog B,Splicing factor, argin... |
Human | Baculovirus Insect Cells |
Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA. | |||
TMPJ-00945 |
HPCAL1 Protein, Human, Recombinant (His)
Hippocalcin-Like Protein 1,HLP2,HPCAL1,VILIP-3,Calcium-Bindi... |
Human | E. coli |
Hippocalcin-Like Protein 1 (HPCAL1) is a neuron-specific calcium-binding member of the recoverin family which found in the retina and brain. HPCAL1 contains four EF-hand domains and it is highly similar to human hippocalcin protein. HPCAL1 is involved in the calcium-dependent regulation of rhodopsin phosphorylation. In addition, it may be of relevance for neuronal signalling in the central nervous system. | |||
TMPJ-01148 |
NRN1L Protein, Human, Recombinant (His)
NRN1L,UNQ2446/PRO5725,Neuritin-like protein |
Human | HEK293 Cells |
Neuritin-like protein belongs to the neuritin family. Neuritin is a GPI-anchored protein that promotes neurite outgrowth and branching of neuritic processes in primary hippocampal and cortical cells. Neuritin expression also enhances the development of motor neuron axon arbors by promoting neuromuscular synaptogenesis and by stimulating the addition of new axon branches. Neuritin is induced by neuronal activity and by the neurotrophins, BDNF and NT3. NRN1L contains a consensus cleavage signal fo... | |||
TMPK-00495 |
CADM3 Protein, Cynomolgus, Recombinant (His)
NECL1,IGSF4B,CADM3,TSLC1-like 1,GSF4B,NECL-1,TSLL1,SynCAM3,m... |
Cynomolgus | HEK293 Cells |
Cell adhesion molecules belonging to the Cadm family, and in particular Cadm3 (axonal) and its heterophilic binding partner Cadm4 (Schwann cell), mediate these interactions along the internode.over-expressing Cadm3 on the surface of DRG neuron axons results in an almost complete inability by Schwann cells to form myelin segments. Axons of superior cervical ganglion (SCG) neurons, which do not normally support the formation of myelin segments by Schwann cells, express higher levels of Cadm3 compa... | |||
TMPK-00996 |
SEZ6 Protein, Human, Recombinant (His & Avi), Biotinylated
BSRPC,BSRP-C,SEZ6,SEZ-6 |
Human | HEK293 Cells |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predi... | |||
TMPH-01064 |
CCR4 Protein, Human, Recombinant (His & SUMO)
CMKBR4,CD194,K5-5,CCR-4,C-C chemokine receptor type 4,CC-CKR... |
Human | E. coli |
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. CCR4 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expressio... | |||
TMPK-01065 |
SEZ6 Protein, Mouse, Recombinant (His)
BSRP-C,SEZ-6,BSRPC,SEZ6 |
Mouse | HEK293 Cells |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is... | |||
TMPK-00998 |
SEZ6 Protein, Human, Recombinant (His)
BSRPC,BSRP-C,SEZ-6,SEZ6 |
Human | HEK293 Cells |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is... | |||
TMPK-00997 |
SEZ6 Protein, Human, Recombinant (hFc)
SEZ-6,BSRP-C,SEZ6,BSRPC |
Human | HEK293 Cells |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is... | |||
TMPJ-00104 |
SOD2 Protein, Human, Recombinant (E. coli, His)
SOD2,Superoxide Dismutase [Mn] Mitochondrial |
Human | E. coli |
Superoxide Dismutase (SOD2) is a number of the iron/manganese superoxide dismutase family. SOD2 is a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. The SOD2 protein transforms toxic superoxide and a byproduct of the mitochondrial electron transport chain into hydrogen peroxide and diatomic oxygen. Genetic variation in SOD2 is associated with microvascular complications of diabetes type 6 (MVCD6), idiopathic cardiomyopathy (IDC), sporadic motor neuron dis... | |||
TMPH-01065 |
CCR4 Protein-VLP, Human, Recombinant (His)
CC-CKR-4,CCR4,CCR-4,CD194,C-C chemokine receptor type 4,K5-5... |
Human | HEK293 Cells |
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. CCR4 Protein-VLP, Human, Recombinant (His) is expressed in HEK293 mammalian cel... | |||
TMPJ-00100 |
Artemin Protein, Human, Recombinant
ARTN,Artemin,EVN,Enovin,Neublastin |
Human | E. coli |
Human Artemin is a GDNF family ligand that is distantly related to the TGF-β superfamily of molecules. It is synthesized as a preproprotein, and contains a variable length pre-, or signal sequence, plus a 68 amino acid (aa) proregion and a 113 aa mature segment. Following synthesis and proteolytic processing, mature ARTN is secreted as a presumably glycosylated, 28 kDa disulfide-linked homodimer that contains three intrachain disulfide bonds and the typical TGF-β signature cysteine-knot motif. I... | |||
TMPH-02229 |
TRA2B Protein, Human, Recombinant (His & SUMO)
TRA2B,Transformer-2 protein homolog B,Splicing factor, argin... |
Human | E. coli |
Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA. TRA2B Protein, Human, Recombinant (His & SUMO) is expr... | |||
TMPY-02682 |
NELL2 Protein, Human, Recombinant (His)
NEL-like 2 (chicken),NRP2 |
Human | Baculovirus Insect Cells |
A brain-enriched secreting signal peptide, NELL2, has been suggested to play multiple roles in the development, survival, and activity of neurons in the mammal. NELL2 is an abundant glycoprotein containing an EGF-like domain in the neural tissues where it has multiple physiological functions by interacting with protein kinase C (PKC). There are two different splicing variant forms of NELL2 identified so far. One is secreted NELL2 (sNELL2) which is a neuron-specific variant and the other is cytos... | |||
TMPJ-00773 |
TUBB4A Protein, Human, Recombinant (His)
Tubulin β-4A Chain,Tubulin 5 β,TUBB4,TUBB5,Tubulin Beta-4A C... |
Human | E. coli |
Tubulin Beta-4A Chain (TUBB4A) is a cytoplasmic peptide containing 444 amino acids. TUBB4A is a member of the Tubulin family. Tubulin is the major constituent of microtubules. Tubulin is a dimer composed of one alpha and one beta tubulin molecule; there are many forms of beta tubulins, Beta II and Beta IV Tubulin are ubiquitously expressed. Beta-III Tubulin, also known as Tubulin Beta-4, is regarded as a neuron-specific marker. It binds two moles of GTP, one at an exchangeable site on the beta c... | |||
TMPJ-00290 |
GFR Alpha-2/GFRA2 Protein, Human, Recombinant (hFc & His)
TRNR2,GDNFR-beta,TGF-β-related neurotrophic factor receptor ... |
Human | HEK293 Cells |
GDNF family receptor alpha-2 is a glycosylphosphatidylinosito l (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It also able to mediate GDNF signaling through the RET tyrosine kina... | |||
TMPJ-00366 |
GAS6 Protein, Human, Recombinant (hFc)
AXLLG,Gas6,GAS-6,AXLLGAXL stimulatory factor,growth arrest-s... |
Human | HEK293 Cells |
GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification ... | |||
TMPJ-00365 |
GAS6 Protein, Human, Recombinant (Avi & His), Biotinylated
AXLLG,Growth arrest-specific protein 6,AXL receptor tyrosine... |
Human | HEK293 Cells |
Human Growth arrest-specific protein 6 (GAS6) is ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, plat... | |||
TMPY-03501 |
Optineurin Protein, Human, Recombinant (His & GST)
optineurin,HIP7,ALS12,HYPL,TFIIIA-INTP,FIP2,NRP,GLC1E |
Human | Baculovirus Insect Cells |
OPTN (Optineurin) is a Protein Coding gene. The Optineurin gene encodes the coiled-coil containing protein optineurin. Optineurin is a multifunctional adaptor protein intimately involved in various vesicular trafficking pathways. Through interactions with an array of proteins, such as myosin VI, huntingtin, Rab8, and Tank-binding kinase 1, as well as via its oligomerization, optineurin can act as an adaptor, scaffold, or signal regulator to coordinate many cellular processes associated with the ... | |||
TMPJ-01074 |
PKCE Protein, Human, Recombinant (His)
PRKCE,PKCE,nPKC-ε,nPKC-Epsilon,Protein Kinase C Epsilon Type... |
Human | E. coli |
Protein Kinase C Epsilon type is a member of the serine- and threonine-specific protein kinase family that can be activated by calcium and the second messenger diacylglycerol. Protein Kinase C Epsilon contains these domains: one AGC-kinase C-terminal domain, one C2 domain, one protein kinase domain and two phorbol-ester/DAG-type zinc fingers. Protein Kinase C Epsilon phosphorylate a variety of protein targets and has been identified to participate in diverse cellular signaling pathways. It has m... | |||
TMPY-04999 |
GAS6 Protein, Human, Recombinant (His)
|
Human | HEK293 cells |
GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification ... | |||
TMPJ-00467 |
Mindin Protein, Human, Recombinant (His)
Spondin-2,Differentially expressed in cancerous and non-canc... |
Human | HEK293 Cells |
Spondin-2, also referred to as mindin, belongs to the F-spondin family of secreted extracellular matrix proteins. Spondins are characterised by the presence of F-spondin domains 1 and 2 (FS1 and FS2) at the N-terminus and a thrombospondin-type 1 repeat (TSR1) domain at the C-terminus. Spondin-2 functions as a pattern-recognition molecule for bacterial and viral pathogens and as an integrin ligand for inflammatory cell recruitment and T cell priming. In addition to its roles in promoting neuron o... | |||
TMPH-02156 |
SOCS1 Protein, Human, Recombinant (His)
SOCS1,STAT-induced STAT inhibitor 1,JAK-binding protein,Tec-... |
Human | P. pastoris (Yeast) |
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Through binding to JAKs and IFNGR1, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron surviv... | |||
TMPJ-00448 |
NRG1 beta 1 Protein, Human, Recombinant (aa 2-246)
NRG1β,HGL,NDF,NRG1,HRGA,HRG1-beta 1,Pro-neuregulin-1,HRG1-β1... |
Human | E. coli |
Pro-neuregulin-1,Neuregulin-1 beta 1(NRG1) is a single-pass type I membrane protein and belongs to the neuregulin family .It contains 1 EGF-like domain and 1 Ig-like C2-type (immunoglobulin-like) domain. Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. The protein concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and ... | |||
TMPH-02217 |
SMARCA4 Protein, Human, Recombinant (His)
Transcription activator BRG1,Protein brahma homolog 1,SWI/SN... |
Human | P. pastoris (Yeast) |
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor compl... | |||
TMPY-04556 |
CDK5 Protein, Human, Recombinant (GST)
PSSALRE,cyclin-dependent kinase 5 |
Human | Baculovirus Insect Cells |
Cell division protein kinase 5, also known as Cyclin-dependent kinase 5, Serine/threonine-protein kinase PSSALRE, Tau protein kinase II catalytic subunit, TPKII catalytic subunit and CDK5, is a cytoplasm protein which belongs to theprotein kinase superfamily, CMGC Ser/Thr protein kinase family and CDC2 / CDKX subfamily. Cyclin-dependent kinases (Cdks) are a family of proline-directed Ser/Thr kinases known for their role in the control of cell cycle progression. In 1992, this family was jo... | |||
TMPH-01282 |
ELAVL4 Protein, Human, Recombinant (His & Myc & SUMO)
PNEM,ELAVL4,HuD,Hu-antigen D,ELAV-like protein 4 |
Human | E. coli |
RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs. Plays a role in the regulation of mRNA stability, alternative splicing and translation. Binds to AU-rich element (ARE) sequences in the 3' untranslated region (UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA. Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function. By binding to th... | |||
TMPH-02613 |
ATF-5 Protein, Mouse, Recombinant (His & Myc)
Transcription factor ATFx,Transcription factor-like protein ... |
Mouse | E. coli |
Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation. Its transcrip... | |||
TMPH-02690 |
PLA2G10 Protein, Mouse, Recombinant (His & Myc)
Pla2g10,Group X secretory phospholipase A2,Phosphatidylcholi... |
Mouse | E. coli |
Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with preference for phosphatidylcholines and phosphatidylglycerols over phosphatidylethanolamines. Preferentially releases sn-2 omega-6 and omega-3 polyunsaturated fatty acyl (PUFA) chains over saturated fatty acyls. Contributes to phospholipid remodeling of very low-density lipoprotein (VLDL), low-density li... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T70186 |
Methazolamide-d6
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Methazolamide-d6 is intended for use as an internal standard for the quantification of methazolamide by GC- or LC-MS. Methazolamide is a carbonic anhydrase inhibitor. It reduces intraocular pressure and cerebrospinal fluid flow in a rat model of glaucoma. Methazolamide reduces electroshock-induced seizures in rats with an ED50 value of 19.2 mg/kg. It also inhibits production of reactive oxygen species (ROS) in a primary cortical neuron (PCN) cellular model of subarachnoid hemorrhage (SAH) and re... | |||
T36903 |
Rasagiline-13C3 (mesylate)
Rasagiline-13C3 (mesylate) |
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Rasagiline-13C3is intended for use as an internal standard for the quantification of rasagiline by GC- or LC-MS. Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50= 4.43 nM for the rat brain enzyme).1It is selective for MAO-B over MAO-A (IC50= 412 nM for the rat brain enzyme). It inhibits serum and NGF withdrawal-induced apoptosis of PC12 cells when used at concentrations ranging from 0.01 to 100 μM.2Rasagiline inhibits rat brain MAO-Bin vivo(ED50= 0.1 mg/kg).1It reduces cerebral ede... | |||
T35789 |
Palmitic acid-1-13C
|
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Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.1 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.2 Palmitic acid is involved in the acylation of proteins to anchor membrane-bound proteins to the lipid bilayer.2,3,4,5,6 |1. Santos, M.J., López-Jurado, M., Llopis, J., et a... | |||
T35791 |
Palmitic acid-13C
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Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid-13C contains 13C at the C2 position and has been used in the study of free fatty acid incorporation into phospholipid fatty acids in soil microbes.1 Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.2 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.3 Palmitic ... |