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148

抑制剂 & 化合物

25

天然产物

1

化合物库

62

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5

同位素标记化合物

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Cat. No. Product Name
L7110 抗高血压化合物库

678 compounds
678 种高血压相关的小分子,用于高通量和高内涵筛选;

化合物库

抗高血压化合物库
Cat.No: L7110
Compounds: 678
Cat. No. Product Name Target Signaling Pathways
T1880 P7C3

Others Others
P7C3 是一种 aminopropyl carbazole 类化合物,具有口服活性,可透过血脑屏障,具有神经保护作用。它可用于神经退行性疾病,如帕金森病的研究。
T9530 W 36017

Others Others
W36017 是利多卡因的一种杂质,其阻滞神经活性的pKa为 7.4。
T16766 Ro 08-2750

Others Others
Ro 08-2750 是一种非肽和可逆的神经生长因子 (NGF) 抑制剂,与 NGF 结合,IC50 约为 1 µM。它是一种选择性 MSI RNA 结合活性抑制剂,IC50 为 2.7 μM。它选择性抑制 NGF 与 p75NTR 的结合,而不是 TRKA。
T4542 Clonixin

Clonixic acid,氯尼辛

Others Others
Clonixin (Clonixic acid) 是一种非甾体抗炎药,具有口服活性。
T40045 Sivopixant

S-600918,Sivopixant

P2X Receptor Membrane transporter/Ion channel; Neuroscience
Sivopixant (S-600918) 是P2X3受体选择性拮抗剂 (P2X3IC50=4.2 nM; P2X2/3IC50=1100 nM)。Sivopixant 可用于缓解疼痛的研究。
T6052 GW 441756

Apoptosis; Raf; Trk receptor; CDK Apoptosis; Cell Cycle/Checkpoint; MAPK; Tyrosine Kinase/Adaptors
GW 441756 是一种高特异性神经生长因子受体酪氨酸激酶 a 抑制剂 ,IC50值为 2 nM,可消除 BmK NSPK 诱导神经突生长。
T8834 EST64454 hydrochloride

EST64454

Sigma receptor GPCR/G Protein
EST64454 hydrochloride (EST64454) 是一种可口服的选择性sigma-1受体拮抗剂,Ki 为 22 nM。它有用于疼痛的研究潜力。
T1234 5,5-Dimethyloxazolidine-2,4-dione

Dimethadion,Dimethadione,二甲双酮,Dimethyloxazolidinedione

Calcium Channel Membrane transporter/Ion channel; Metabolism
5,5-Dimethyloxazolidine-2,4-dione (Dimethadione) 是抗惊厥药,是 TRIMETHADIONE 的活性代谢物。
T7748 Dermorphin TFA

皮啡肽三氟乙酸盐

Others; Opioid Receptor Endocrinology/Hormones; GPCR/G Protein; Neuroscience; Others
Dermorphin TFA 是在两栖类皮肤中发现的天然七肽,是 μ-阿片受体激动剂,可用于抑制神经痛。
T11861 LM11A-31 dihydrochloride

Others Others
LM11A-31 dihydrochloride 是一种具有高血脑屏障通透性的氨基酸衍生物,能阻断 p75 介导的细胞死亡。它是一种 p75NTR(神经营养蛋白受体 p75) 非肽调节剂,是口服有效的 proNGF 拮抗剂。它可以逆转中晚期的阿尔茨海默氏病小鼠模型中的胆碱能神经突营养不良。
T0378 Oxybuprocaine hydrochloride

Risedronic Acid,Oxybuprocaine HCl,奥布卡因盐酸盐

Sodium Channel Membrane transporter/Ion channel
Oxybuprocaine hydrochloride (Oxybuprocaine HCl) 是可逆的钠通道阻断剂,可防止角膜,结膜和巩膜中疼痛神经的冲动传播。Oxybuprocaine hydrochloride 专用于眼科与耳鼻喉科。
T15781 LP-935509

Serine/threonin kinase; AAK1 (AP2 associated kinase 1) Cell Cycle/Checkpoint; Metabolism; Neuroscience
LP-935509 是一种选择性的、具有脑渗透的、小分子的衔接蛋白-2 相关激酶1 (AAK1) ATP 竞争性抑制剂,其 IC50=3.3 nM,Ki=0.9 nM。它是一种 BIKE 的有效抑制剂 (IC50=14 nM) 和中度的 GAK 抑制剂 (IC50=320 nM)。它能够逆转 SNL 手术后的疼痛。
T9263 cim0216

N-(5-methyl-1,2-oxazol-3-yl)-2-phenyl-2-(1,2,3,4-tetrahydroquinolin-1-yl)acetamide

TRP/TRPV Channel Membrane transporter/Ion channel
CIM0216 是选择性的TRPM3激动剂,对 TRPM3 的选择性高于 TRPM1、TRPM2 和 TRPM4-8。它以TRPM3依赖性的方式引起疼痛并唤起感觉神经末梢的神经肽释放,可用于神经源性炎症的相关研究。
T1111 Pralidoxime Chloride

2-PAM chloride,吡啶醛肟甲氯,2-Pyridinealdoxime methochloride,2-PAM (chloride)

AChE Neuroscience
Pralidoxime Chloride (2-PAM chloride) 是一种肟类化合物,对中毒乙酰胆碱酯酶具有恢复作用,可用于有机磷中毒的研究。
T7404 Dermorphin

皮啡肽

Opioid Receptor Endocrinology/Hormones; GPCR/G Protein; Neuroscience
Dermorphin 是在两栖类皮肤中发现的天然七肽,是 μ-阿片受体激动剂,可用于抑制神经痛。
T23401 Strontium chloride

Others; CaSR GPCR/G Protein; Others
Strontium chloride 是钙敏感受体 (CaSR) 的激动剂,并可以直接影响 C 型神经纤维。
T0924 Benzocaine

苯唑卡因,苯佐卡因

Others; MRP; Sodium Channel Immunology/Inflammation; Membrane transporter/Ion channel; Others
Benzocaine 作用电压门控 Na+通道的共同受体,+30 mV 下的 IC50为0.8 mM。
T8762 SW106065

SW-106065

Apoptosis Apoptosis
SW106065 是一种恶性外周神经鞘瘤(MPNST)细胞凋亡诱导剂。 它抑制 sMPNST 和其他 MPNST 模型的 ATP 消耗,EC50 为 1 µM。
T34373 RO5166017

RO 5166017,RO-5166017

Others Others
RO5166017 是一种具有口服活性、高效性和选择性的痕量胺相关受体 1(TAAR1)激动剂,可用于研究条件性味觉厌恶额神经障碍。
T62893 SM-2470

Adrenergic Receptor GPCR/G Protein; Neuroscience
SM-2470 是一种α1-adrenoceptor拮抗剂,具有降压活性,可减低前神经节肾上腺神经活性和主动脉降压神经活性。SM-2470 具有降胆固醇活性,可抑制胆固醇吸收。
T22361 Mepivacaine

Carbocaine

Sodium Channel Membrane transporter/Ion channel
Mepivacaine (Carbocaine) 是一种可用于局部麻醉的酰胺类化合物,可使人或动物短暂的失去自知觉。Mepivacaine 通过与神经细胞膜上特定的电压门控钠离子通道结合,抑制钠离子内流和膜去极化来发挥作用。Mepivacaine 适用于神经阻滞和硬膜外麻醉。
T4397 DIM-C-pPhOCH3

C-DIM5

Others Others
DIM-C-pPhOCH3 (C-DIM5) 是 Nur77 激动剂。其中 Nur77 是孤儿核受体。
T77663 1-Benzyl-3-Phenylthiourea

1-Benzyl-3-Phenyl-2-Thiourea

Others Others
1-Benzyl-3-Phenylthiourea (1-Benzyl-3-Phenyl-2-Thiourea) 可用作检测神经毒剂和相关兴奋剂的传感材料。
T37688 Cyfluthrin

Reactive Oxygen Species; Sodium Channel Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB
Cyfluthrin 属于 II 型拟除虫菊酯,对多种昆虫都有杀灭效果。Cyfluthrin 是Nav1.8钠通道调节剂。它可应用于农业、兽医、杀虫剂、拟除虫菊酯和贮存产品等领域。
T13830 Propoxycaine hydrochloride

Propoxycaine HCl

Sodium Channel Membrane transporter/Ion channel
Propoxycaine hydrochloride 是一种酯类局部麻醉剂,抑制电压门控的钠通道,可调节神经冲动,可诱导感觉丧失。Propoxycaine hydrochloride 可调节SPMVs脂质双层的流动。
T12160 N6-Cyclohexyladenosine

CHA,A1受体促进剂

Adenosine Receptor GPCR/G Protein; Neuroscience
N6-Cyclohexyladenosine (CHA) 是一种选择性腺苷 A1 受体激动剂,EC50 为 8.2 nM。
T5585 AM-92016 hydrochloride

Potassium Channel Membrane transporter/Ion channel
AM-92016 hydrochloride 是一种整流钾电流的特异性阻断剂。它能够延迟整流钾通道,使膜复极化,限制神经冲动的持续时间。
T67980 Coleneuramide

MCC-257

Others Others
Coleneuramide (MCC-257)可增强神经生长因子 (NGF) 对细胞存活的影响,可用于研究糖尿病性多发性神经病。
T25102 Aprikalim

RP-52891,RP 52891,RP52891

Potassium Channel Membrane transporter/Ion channel
Aprikalim (RP 52891) 是一种三磷酸腺苷钾通道(KATP)开启剂,可保护脊髓缺血兔模型中的神经受到损伤。Aprikalim 抑制血管收缩,抑制心肌麻痹期间 [Ca2+]i 升高,可以用于研究心血管疾病。
T12269 NUCC-390

CXCR Autophagy; GPCR/G Protein; Immunology/Inflammation
NUCC-390 是新型的选择性小分子 CXCR4 receptor 受体激动剂。NUCC-390 可以诱导 CXCR4 受体的内化,作用方式与 AMD3100相反。NUCC-390 在动物模型中,有助于神经退行性变后神经功能恢复。
T9234 Tocainide hydrochloride

2-amino-n-(2,6-dimethylphenyl)propanamide hydrochloride

Sodium Channel Membrane transporter/Ion channel
Tocainide hydrochloride (2-amino-n-(2,6-dimethylphenyl)propanamide hydrochloride) 是利多卡因的伯胺类似物,是钠通道阻滞剂,在产生疼痛的病灶中(神经膜上) 阻断钠通道。Tocainide hydrochloride 具有用于心律不齐研究的价值。
T0025 Haloperidol

Aloperidin,氟哌啶醇,Serenace,Haldol

Dopamine Receptor; 5-HT Receptor GPCR/G Protein; Neuroscience
Haloperidol (Serenace) 是一种安定药,是一种dopamine D2 receptor 拮抗剂。
T15756 Lidorestat

IDD-676

Reductase Endocrinology/Hormones; Metabolism
Lidorestat (IDD-676) 是一种醛糖还原酶抑制剂(IC50: 5 nM),具有有效性,选择性和口服活性。Lidorestat 改善神经传导,减少白内障的形成。Lidorestat 可用于治疗慢性糖尿病并发症。
T15212 Emamectin Benzoate

MK-244,甲胺基阿维菌素苯甲酸盐

Apoptosis; Reactive Oxygen Species; GABA Receptor; Parasite Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; NF-κB
Emamectin Benzoate (MK-244) 是口服有效的神经系统毒物,其通过结合昆虫中的 GABA 受体发挥作用。它是阿维菌素的半合成衍生物之一,具有广谱的杀虫和杀螨活性。它诱导ROS 介导的 DNA 损伤和细胞凋亡。
T27509 GW-493838

GW 493838X,GW 493838,GW493838,GW493838X,GW-493838X

Adenosine Receptor GPCR/G Protein; Neuroscience
GW-493838是一种有效的腺苷 A1A 受体激动剂,用于治疗血脂异常和神经性疼痛,对创伤或手术引起的疱疹后神经痛或周围神经损伤具有镇痛效果。
T8869 B355252

Others Others
B355252 是苯氧基噻吩磺酰胺小分子,NGF 受体激动剂。它能增强 NGF 诱导的神经突生长。它可减轻 DNA 损伤、抑制 ROS 生成、降低 LDH 水平以及预防神经元凋亡,保护缺血性神经元免受神经元损失。它具有抗细胞凋亡作用。
T9272 Xaliproden hydrochloride

Dopamine Receptor; 5-HT Receptor GPCR/G Protein; Neuroscience
Xaliproden hydrochloride 是选择性和具有口服活性的5-HT1A 受体激动剂,对大鼠海马中的 5-HT1A 特异性结合位点表现出高亲和力。它也是选择性的多巴胺D2受体拮抗剂,具有抗抑郁和抗焦虑作用,有用于神经退行性疾病的研究潜力。
T6645 Ropivacaine hydrochloride monohydrate

Ropivacaine HCl,Ropivacaine HCl monohydrate,LEA 103,盐酸罗哌卡因,盐酸罗哌卡因一水合物,LEA-103 HCl

Potassium Channel; Sodium Channel Membrane transporter/Ion channel
Ropivacaine hydrochloride monohydrate (LEA-103 HCl) 是钠通道阻断剂,通过可逆地抑制钠离子内流从而引起神经纤维脉冲传导阻滞。Ropivacaine HCl monohydrate 也是 K2P(双孔钾通道)TREK-1的抑制剂。在动物实验模型中,Ropivacaine HCl monohydrate 可用于神经性疼痛的缓解。
T14127 Adenosine A1 receptor activator T62

Adenosine Receptor GPCR/G Protein; Neuroscience
Adenosine A1 receptor activator T62 是腺苷 A1 受体的变构增强剂,有镇痛作用。
T11717 JHU395

Apoptosis Apoptosis
JHU395 是一种口服生物利用度高的前药,其活性成分是亲脂性谷氨酸拮抗剂(GA,6-叠氮-5-酮-L-去亚硝基赖氨酸)。JHU395 能有效地将DON输送至恶性周围神经鞘瘤(MPNST)的体外和体内模型中,并在MPNST上显现出显著的抗肿瘤活性。此外,JHU395在血浆中表现出良好的稳定性。
T78105 PAC1R antagonist 1

PACAP GPCR/G Protein
PAC1R antagonist 1为一种具有口服活性的 PAC1 受体拮抗剂,可抑制由垂体腺苷酸环化酶激活多肽(PACAP)及神经损伤所诱导的异常性疼痛,可用于研究肿瘤和与免疫相关的疾病。
T5030 Zofenopril calcium

SQ26991,佐芬普利钙,Zofenopril (calcium)

RAAS; Reactive Oxygen Species Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB
Zofenopril calcium (SQ26991) 是一种抗氧化剂和血管紧张素转化酶 (ACE) 抑制剂。
T38654 Cotosudil

ROCK Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
Cotosudil 是一种 ROCK 激酶抑制剂,具有抗高血压活性,可用于治疗或预防白内障、心血管疾病或神经退行性疾病或神经损伤引起的疾病或病症。
T0029 Procaine

Duracaine,Spinocaine,普鲁卡因,Novocaine,Vitamin H3,奴夫卡因

Histone Demethylase; DNA/RNA Synthesis; Sodium Channel Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Membrane transporter/Ion channel
Procaine (Vitamin H3) 是DNA 脱甲基剂,是一种酯类局部麻醉剂。它起效缓慢,作用持续时间短,主要用于浸润麻醉、周围神经阻滞和脊髓阻滞。
T6707 Tiotropium Bromide hydrate

BA-679 BR hydrate,BA 679BR,噻托溴铵一水合物

AChR Neuroscience
Tiotropium Bromide hydrate (BA-679 BR hydrate) 是长效的毒蕈碱受体拮抗剂,可用于治疗慢性阻塞性气道疾病 (COPD)。
T4497 Amifampridine

3,4-Pyridinediamine,Pyridine-3,4-Diamine,阿米吡啶,3,4-Diaminopyridine

Others Others
Amifampridine (3,4-Diaminopyridine) 可用于罕见肌肉疾病的研究。
T10659 Ca2+ channel agonist 1

Calcium Channel; CDK Cell Cycle/Checkpoint; Membrane transporter/Ion channel; Metabolism
Ca2+channel agonist 1 是 N-型钙离子通道激动剂和Cdk2的抑制剂,EC50分别为 14.23 μM 和 3.34 μM,可用作运动神经末梢功能障碍的潜在治疗方法。
T13177 Taquidil

Others Others
Tocainide hydrochloride 是一种sodium channel 阻滞剂,它阻断神经膜中产生疼痛的病灶中的钠通道。Tocainide hydrochloride 是利多卡因 (lignocaine) 的一种伯胺类似物,可有效抑制各种情况下的室性心律失常。
T16723 Ranirestat

AS3201,SX3030,SX-3030,AS 3201,AS-3201

Reductase Endocrinology/Hormones; Metabolism
Ranirestat (AS-3201) 是一种具有口服活性和高效性的醛糖还原酶 (AR) 抑制剂,具有神经保护作用,可改善晚期糖尿病多发性神经病大鼠的周围神经功能障碍。Ranirestat 抑制高葡萄糖暴露内皮细胞的炎症反应,可用于研究糖尿病感觉运动性多发性神经病。
TP1413L Crustacean Cardioactive Peptide Acetate

CCAP acetate

Crustacean Cardioactive Peptide Acetate (CCAP acetate) 是 是节肢动物中最保守和普遍存在的神经肽,在昆虫中由腹侧神经索中的保守神经元网络产生。Crustacean Cardioactive Peptide Acetate 是一种环酰胺化九肽激素,常见于昆虫,甲壳类动物和其他节肢动物中。

化合物

P7C3
Cat.No: T1880
Synonym:
Target: Others
W 36017
Cat.No: T9530
Synonym:
Target: Others
Ro 08-2750
Cat.No: T16766
Synonym:
Target: Others
Clonixin
Cat.No: T4542
Synonym: Clonixic acid,氯尼辛
Target: Others
Sivopixant
Cat.No: T40045
Synonym: S-600918,Sivopixant
Target: P2X Receptor
GW 441756
Cat.No: T6052
Synonym:
Target: Apoptosis, Raf, Trk receptor, CDK
EST64454 hydrochloride
Cat.No: T8834
Synonym: EST64454
Target: Sigma receptor
5,5-Dimethyloxazolidine-2,4-dione
Cat.No: T1234
Synonym: Dimethadion,Dimethadione,二甲双酮,Dimethyloxazolidinedione
Target: Calcium Channel
Dermorphin TFA
Cat.No: T7748
Synonym: 皮啡肽三氟乙酸盐
Target: Others, Opioid Receptor
LM11A-31 dihydrochloride
Cat.No: T11861
Synonym:
Target: Others
Oxybuprocaine hydrochloride
Cat.No: T0378
Synonym: Risedronic Acid,Oxybuprocaine HCl,奥布卡因盐酸盐
Target: Sodium Channel
LP-935509
Cat.No: T15781
Synonym:
Target: Serine/threonin kinase, AAK1 (AP2 associated kinase 1)
cim0216
Cat.No: T9263
Synonym: N-(5-methyl-1,2-oxazol-3-yl)-2-phenyl-2-(1,2,3,4-tetrahydroquinolin-1-yl)acetamide
Target: TRP/TRPV Channel
Pralidoxime Chloride
Cat.No: T1111
Synonym: 2-PAM chloride,吡啶醛肟甲氯,2-Pyridinealdoxime methochloride,2-PAM (chloride)
Target: AChE
Dermorphin
Cat.No: T7404
Synonym: 皮啡肽
Target: Opioid Receptor
Strontium chloride
Cat.No: T23401
Synonym:
Target: Others, CaSR
Benzocaine
Cat.No: T0924
Synonym: 苯唑卡因,苯佐卡因
Target: Others, MRP, Sodium Channel
SW106065
Cat.No: T8762
Synonym: SW-106065
Target: Apoptosis
RO5166017
Cat.No: T34373
Synonym: RO 5166017,RO-5166017
Target: Others
SM-2470
Cat.No: T62893
Synonym:
Target: Adrenergic Receptor
Mepivacaine
Cat.No: T22361
Synonym: Carbocaine
Target: Sodium Channel
DIM-C-pPhOCH3
Cat.No: T4397
Synonym: C-DIM5
Target: Others
1-Benzyl-3-Phenylthiourea
Cat.No: T77663
Synonym: 1-Benzyl-3-Phenyl-2-Thiourea
Target: Others
Cyfluthrin
Cat.No: T37688
Synonym:
Target: Reactive Oxygen Species, Sodium Channel
Propoxycaine hydrochloride
Cat.No: T13830
Synonym: Propoxycaine HCl
Target: Sodium Channel
N6-Cyclohexyladenosine
Cat.No: T12160
Synonym: CHA,A1受体促进剂
Target: Adenosine Receptor
AM-92016 hydrochloride
Cat.No: T5585
Synonym:
Target: Potassium Channel
Coleneuramide
Cat.No: T67980
Synonym: MCC-257
Target: Others
Aprikalim
Cat.No: T25102
Synonym: RP-52891,RP 52891,RP52891
Target: Potassium Channel
NUCC-390
Cat.No: T12269
Synonym:
Target: CXCR
Tocainide hydrochloride
Cat.No: T9234
Synonym: 2-amino-n-(2,6-dimethylphenyl)propanamide hydrochloride
Target: Sodium Channel
Haloperidol
Cat.No: T0025
Synonym: Aloperidin,氟哌啶醇,Serenace,Haldol
Target: Dopamine Receptor, 5-HT Receptor
Lidorestat
Cat.No: T15756
Synonym: IDD-676
Target: Reductase
Emamectin Benzoate
Cat.No: T15212
Synonym: MK-244,甲胺基阿维菌素苯甲酸盐
Target: Apoptosis, Reactive Oxygen Species, GABA Receptor, Parasite
GW-493838
Cat.No: T27509
Synonym: GW 493838X,GW 493838,GW493838,GW493838X,GW-493838X
Target: Adenosine Receptor
B355252
Cat.No: T8869
Synonym:
Target: Others
Xaliproden hydrochloride
Cat.No: T9272
Synonym:
Target: Dopamine Receptor, 5-HT Receptor
Ropivacaine hydrochloride monohydrate
Cat.No: T6645
Synonym: Ropivacaine HCl,Ropivacaine HCl monohydrate,LEA 103,盐酸罗哌卡因,盐酸罗哌卡因一水合物,LEA-103 HCl
Target: Potassium Channel, Sodium Channel
Adenosine A1 receptor activator T62
Cat.No: T14127
Synonym:
Target: Adenosine Receptor
JHU395
Cat.No: T11717
Synonym:
Target: Apoptosis
PAC1R antagonist 1
Cat.No: T78105
Synonym:
Target: PACAP
Zofenopril calcium
Cat.No: T5030
Synonym: SQ26991,佐芬普利钙,Zofenopril (calcium)
Target: RAAS, Reactive Oxygen Species
Cotosudil
Cat.No: T38654
Synonym:
Target: ROCK
Procaine
Cat.No: T0029
Synonym: Duracaine,Spinocaine,普鲁卡因,Novocaine,Vitamin H3,奴夫卡因
Target: Histone Demethylase, DNA/RNA Synthesis, Sodium Channel
Tiotropium Bromide hydrate
Cat.No: T6707
Synonym: BA-679 BR hydrate,BA 679BR,噻托溴铵一水合物
Target: AChR
Amifampridine
Cat.No: T4497
Synonym: 3,4-Pyridinediamine,Pyridine-3,4-Diamine,阿米吡啶,3,4-Diaminopyridine
Target: Others
Ca2+ channel agonist 1
Cat.No: T10659
Synonym:
Target: Calcium Channel, CDK
Taquidil
Cat.No: T13177
Synonym:
Target: Others
Ranirestat
Cat.No: T16723
Synonym: AS3201,SX3030,SX-3030,AS 3201,AS-3201
Target: Reductase
Crustacean Cardioactive Peptide Acetate
Cat.No: TP1413L
Synonym: CCAP acetate
Target:
Cat. No. Product Name Target Signaling Pathways
T8392 L(+)-Asparagine monohydrate

Endogenous Metabolite Metabolism
L(+)-Asparagine monohydrate 是一种非必需氨基酸,参与组织细胞功能的神经和代谢调节。
T2S0843 Negletein

黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether

IL Receptor; TNF; NOS; Interleukin Apoptosis; Immunology/Inflammation
Negletein (7-O-Methylbaicalein) 一种神经保护剂,可增强神经生长因子的作用并诱导 PC12 细胞中的神经突生长。它通过抑制TNF-α和IL-1β表现出抗炎活性,其 IC50值分别为 16.4 和 10.8 μM。它还具有抗菌、抗缺氧和抗阿尔茨海默病活性。
T4396 Officinalisinin I

Others Others
Officinalisinin I 是一种甾体皂苷,分离自 Anemarrhena asphodeloides。
T8264 3-Methyl-2-oxovaleric acid

Endogenous Metabolite Metabolism
3-Methyl-2-oxovaleric acid 是神经毒素,代谢毒素和酸性原,它是支链氨基酸不完整分解产生的异常代谢物。
T5232 3-Methyl-2-oxobutanoic acid

3-甲基-2-氧丁酸,2-Oxoisovaleric acid,alpha-Ketoisovaleric acid

Others; Endogenous Metabolite Metabolism; Others
3-Methyl-2-oxobutanoic acid (2-Oxoisovaleric acid) 是大肠杆菌中泛酸的前体。它是由支链氨基酸的不完全分解产生的一种异常代谢物。
T2O2774 L-Asparagine

alpha-aminosuccinamic acid,L-天门冬氨酸,(-)-Asparagine,Asparamide,2-Aminosuccinamic acid,Asn,Altheine

Endogenous Metabolite Metabolism
L-Asparagine (Asparamide) 是一种非必需氨基酸,可以参与神经和脑组织细胞功能的代谢控制。
T4S1876 3-Deoxyaconitine

Sodium Channel Membrane transporter/Ion channel
3-Deoxyaconitine 是一种二萜类生物碱,对钠离子通道有激活作用。
T4S1519 Pseudoginsenoside RT5

拟人参皂苷RT5

Others Others
Pseudoginsenoside RT5 分离于 Panax quinquefolium 中。它通过促进神经生长和提高认知能力,具有抗癫痫、抗抑郁活性,还具有抗菌、抗肿瘤、抗疟疾等活性。
T1045 Trimipramine maleate

Surmontil maleate,马来酸三甲丙咪嗪,三甲丙咪嗪马来酸盐

Dopamine Receptor; 5-HT Receptor; Antibacterial; Adrenergic Receptor; Norepinephrine; Histamine Receptor GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
Trimipramine maleate (Surmontil maleate) 是一种 5-HT 受体拮抗剂,对 5-HT1C、5-HT2和 5-HT1A 受体的 pKi 值分别为 6.39、8.10和 4.66。
T3836 Eudesmin

MAPK; S6 Kinase MAPK; PI3K/Akt/mTOR signaling
Eudesmin 通过抑制S6K1信号通路来干扰成脂分化,具有抗肿瘤、抗炎和抗菌活性。
T0894 Thiamine hydrochloride

盐酸硫胺素,Vitamin B1,Vitamin B1 hydrochloride,Thiamine HCl,盐酸硫胺(维生素B1),Thiamine chloride hydrochloride

Apoptosis; HBV; Endogenous Metabolite Apoptosis; Metabolism; Microbiology/Virology
Thiamine hydrochloride (Vitamin B1) 是一种必需的微量营养素,是许多中枢代谢酶的辅因子。
T2A2532 L-Histidine

Glyoxaline-5-alanine,L-(-)-Histidine,L-组氨酸,histidine,组氨酸,L-Hisidine

Mitochondrial Metabolism; Endogenous Metabolite Metabolism
L-Histidine (L-(-)-Histidine) 是人类生长和组织修复所需的一种半必需氨基酸(儿童应从食物中获得)。 L-Histidine 是线粒体谷氨酰胺转运的抑制剂。
T3822 Bellidifolin

Bellidifoline,龙胆山酮酚,Bellidifolium,雏菊叶龙胆酮

Others; HIV Protease Microbiology/Virology; Others; Proteases/Proteasome
Bellidifolin (Bellidifoline) 是从獐牙菜的茎中提取的一种呫吨酮,它能作为病毒蛋白 R 的抑制剂,具有保肝、降血糖、抗炎、抗氧化、抗肿瘤作用。
T9279 nerolidol acetate

Others Others
Nerolidol acetate是一种具有抗癌、抗炎、抗菌和抗虫的活性的天然倍半萜。Nerolidol acetate可抑制寄生虫活动,抑制吸血虫病、线虫病以及疟疾等。Nerolidol acetate可保护细胞免受脂质、蛋白质和 DNA 的氧化损伤,对小鼠海马神经细胞具有保护作用。
T2163 Dihydrocapsaicin

CCRIS1589,二氢辣椒素,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide

Others; TRP/TRPV Channel Membrane transporter/Ion channel; Others
Dihydrocapsaicin (CCRIS1589) 是一种天然来源的辣椒素,是TRPV1的选择性激动剂,同时可以增加 p-Akt 水平。它可以增强低温诱导的神经保护。
T82446 Erinacine C

Erinacine C是一种刺激剂,用于促进神经生长因子(NGF)的合成。
TN4123 Gelsemiol

Others Others
Gelsemiol has neurotrophic factor-potentiating activity, markedly enhances an increase in the proportion of neurite-bearing cells and an extension of the neurite length in the presence of nerve growth factor.
T2S1727 Lycorenine

Antifection Microbiology/Virology
Lycorenine may produce a decrease in blood pressure as the result of alpha-adrenergic blockade in conjunction with the reduction of the spontaneous sympathetic nerve activity, and produce bradycardia by modifying vagal activity. The development of tachyph
T81814 Methyl Ganoderic acid B

Methyl Ganoderic acid B, 一种从灵芝中分离得到的三萜类化合物,具有类似神经生长因子的神经元存活促进作用。
TN4126 Gentiside B

Others Others
Gentiside B is a potent inducer of neurite outgrowth on PC12 cells, it shows a significant neuritogenic activity at 30 microM against PC12 cells that is comparable to that seen for the best nerve growth factor (NGF) concentration of 40 ng/mL.
T79983 Flaccidoside II

Apoptosis Apoptosis
Flaccidoside II 是一种源自Anemone flaccida根茎的三萜皂苷,能抑制恶性周围神经鞘瘤(MPNST)细胞系增殖并诱导细胞凋亡(apoptosis)。此外,Flaccidoside II 亦能改善由胶原蛋白引发的小鼠关节炎症状。
T81980 Kissoone C

Kissoone C (compound 3),一种三环倍半萜类,源自缬草根提取。该化合物能增强PC12D细胞中神经生长因子(NGF)介导的神经突生长活性。
T81676 NG-012

NG-012为一种神经生长因子(NGF)增强剂,来源于Penicillium verruculosum F-4542的培养液。该化合物能在大鼠嗜铬细胞瘤细胞系(PC12)中提升NGF引导的神经突生长效应。
TN4291 Isofuranodiene

IL Receptor; NOS Immunology/Inflammation
Isofuranodiene protects GalN/LPS-induced liver injury in SD rats, it may be a potential functional food ingredient for the prevention and treatment of liver diseases. Isofuranodiene has anticancer activity, by inhibiting the proliferation and inducing apo
TN3323 Monomethyl lithospermate

Lithospermic acid monomethyl ester

Akt; PI3K Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
Monomethyl lithospermate (Lithospermic acid monomethyl ester) 具有潜在的抗病毒活性,通过激活PI5K/Akt信号传导,减轻体内大脑中动脉闭塞小鼠缺血性中风损伤,并在体外保护氧葡萄糖剥夺/复氧诱导的SHSY-3Y细胞。Monomethyl lithospermate 能提高 SHSY-5Y 细胞的生存能力,抑制线粒体膜电位 (MMOP) 崩溃,抑制细胞凋亡。Monomethyl lithospermate 还降低中动脉闭塞 (MCAO) 大鼠脑组织中的氧化应激水平,改善缺血性中风 (IS) 大鼠神经损伤。

天然产物

L(+)-Asparagine monohydrate
Cat.No: T8392
Synonym:
Target: Endogenous Metabolite
Negletein
Cat.No: T2S0843
Synonym: 黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether
Target: IL Receptor, TNF, NOS, Interleukin
Officinalisinin I
Cat.No: T4396
Synonym:
Target: Others
3-Methyl-2-oxovaleric acid
Cat.No: T8264
Synonym:
Target: Endogenous Metabolite
3-Methyl-2-oxobutanoic acid
Cat.No: T5232
Synonym: 3-甲基-2-氧丁酸,2-Oxoisovaleric acid,alpha-Ketoisovaleric acid
Target: Others, Endogenous Metabolite
L-Asparagine
Cat.No: T2O2774
Synonym: alpha-aminosuccinamic acid,L-天门冬氨酸,(-)-Asparagine,Asparamide,2-Aminosuccinamic acid,Asn,Altheine
Target: Endogenous Metabolite
3-Deoxyaconitine
Cat.No: T4S1876
Synonym:
Target: Sodium Channel
Pseudoginsenoside RT5
Cat.No: T4S1519
Synonym: 拟人参皂苷RT5
Target: Others
Trimipramine maleate
Cat.No: T1045
Synonym: Surmontil maleate,马来酸三甲丙咪嗪,三甲丙咪嗪马来酸盐
Target: Dopamine Receptor, 5-HT Receptor, Antibacterial, Adrenergic Receptor, Norepinephrine, Histamine Receptor
Eudesmin
Cat.No: T3836
Synonym:
Target: MAPK, S6 Kinase
Thiamine hydrochloride
Cat.No: T0894
Synonym: 盐酸硫胺素,Vitamin B1,Vitamin B1 hydrochloride,Thiamine HCl,盐酸硫胺(维生素B1),Thiamine chloride hydrochloride
Target: Apoptosis, HBV, Endogenous Metabolite
L-Histidine
Cat.No: T2A2532
Synonym: Glyoxaline-5-alanine,L-(-)-Histidine,L-组氨酸,histidine,组氨酸,L-Hisidine
Target: Mitochondrial Metabolism, Endogenous Metabolite
Bellidifolin
Cat.No: T3822
Synonym: Bellidifoline,龙胆山酮酚,Bellidifolium,雏菊叶龙胆酮
Target: Others, HIV Protease
nerolidol acetate
Cat.No: T9279
Synonym:
Target: Others
Dihydrocapsaicin
Cat.No: T2163
Synonym: CCRIS1589,二氢辣椒素,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide
Target: Others, TRP/TRPV Channel
Erinacine C
Cat.No: T82446
Synonym:
Target:
Gelsemiol
Cat.No: TN4123
Synonym:
Target: Others
Lycorenine
Cat.No: T2S1727
Synonym:
Target: Antifection
Methyl Ganoderic acid B
Cat.No: T81814
Synonym:
Target:
Gentiside B
Cat.No: TN4126
Synonym:
Target: Others
Flaccidoside II
Cat.No: T79983
Synonym:
Target: Apoptosis
Kissoone C
Cat.No: T81980
Synonym:
Target:
NG-012
Cat.No: T81676
Synonym:
Target:
Isofuranodiene
Cat.No: TN4291
Synonym:
Target: IL Receptor, NOS
Monomethyl lithospermate
Cat.No: TN3323
Synonym: Lithospermic acid monomethyl ester
Target: Akt, PI3K
Cat. No. Product Name Species Expression System
TMPJ-01469 NGF Protein, Human, Recombinant (E. colli)

NGFB,神经生长因子,β-NGF,NGF,Beta-Nerve Growth Factor,β-

Mouse E. coli
NGF is the first member discovered in the Neurotrophin family, which includes brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Mouse beta -NGF is a homodimer of two 120 amino acid polypeptides. It shares approximately 90% homology at the amino acid level with human beta -NGF and 95.8% with rat beta -NGF. NGF signaling has been shown to play an impo...
TMPY-06985 NGF Protein, Human, Recombinant (HEK293)

NGFB,神经生长因子,Beta-NGF,HSAN5,β-NGF,nerve growth facto...

Human HEK293 Cells
NGF Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 24.8 kDa. and the accession number is P01138.
TMPJ-01468 pro-Beta NGF Protein, Human, Recombinant

β-NGF,NGF,NGFB,Beta-NGF,Beta-Nerve Growth Factor,pr...

Human E. coli
The precursor form of the nerve growth factor (proNGF) like its mature form is characterized by the cystin knot motif consisting of three cystine bridges, whereas proneurotrophins and mature neurotrophins elicit opposite biological effects. ProNGF functions preferentially via the complex of pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin inducing neuronal apoptosis and contributing to age- and disease-related neurodegeneration.
TMPY-01010 NGF Protein, Human, Recombinant

Beta-NGF,神经生长因子,β-NGF,NGFB,nerve growth factor (β p...

Human CHO Cells
NGF Protein, Human, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 13.2 kDa and the accession number is P01138.
TMPY-02614 NGFR/p75NTR Protein, Human, Recombinant (hFc)

神经生长因子,nerve growth factor receptor (TNFR superfami...

Human HEK293 Cells
NGFR/p75NTR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.6 kDa and the accession number is P08138.
TMPY-01402 NGF Protein, Mouse, Recombinant

神经生长因子,nerve growth factor (β polypeptide),Ngfb,

Mouse CHO Cells
NGF Protein, Mouse, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 13.5 kDa and the accession number is P01139.
TMPH-03102 NGF Protein, Pig, Recombinant (His & SUMO)

Beta-nerve growth factor,NGF

Sus scrofa (Pig) E. coli
NGF Protein, Pig, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 29.4 kDa and the accession number is Q29074.
TMPY-04646 NGFR/p75NTR Protein, Rabbit, Recombinant (His)

神经生长因子,nerve growth factor receptor (TNFR superfami...

Rabbit HEK293 Cells
NGFR/p75NTR Protein, Rabbit, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.8 kDa and the accession number is XP_008269543.1.
TMPH-03341 Neurotrophin 3 Protein, Rat, Recombinant (His & Myc)

Neurotrophin-3,Neurotrophic factor,Nerve growth fac...

Rat E. coli
Seems to promote the survival of visceral and proprioceptive sensory neurons. Neurotrophin 3 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 21.1 kDa and the accession number is P18280.
TMPH-01769 Neurotrophin 3 Protein, Human, Recombinant (His)

NTF3,HDNF,Neurotrophic factor,Neurotrophin-3,Nerve ...

Human E. coli
Seems to promote the survival of visceral and proprioceptive sensory neurons. Neurotrophin 3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 17.7 kDa and the accession number is P20783.
TMPY-06973 NGFR/p75NTR Protein, Cynomolgus, Recombinant (His)

nerve growth factor receptor (TNFR superfamily, mem...

Cynomolgus HEK293 Cells
NGFR/p75NTR Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.03 kDa and the accession number is XP_005583674.1.
TMPY-06959 NGFR/p75NTR Protein, Rat, Recombinant (His)

神经生长因子,nerve growth factor receptor (TNFR superfami...

Rat HEK293 Cells
NGFR/p75NTR Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.34 kDa and the accession number is P07174.
TMPY-04831 NGFR/p75NTR Protein, Rabbit, Recombinant (hFc)

NGFR,nerve growth factor receptor (TNFR superfamily...

Rabbit HEK293 Cells
NGFR/p75NTR Protein, Rabbit, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.1 kDa and the accession number is XP_008269543.1.
TMPY-02541 NGFR/p75NTR Protein, Mouse, Recombinant (His)

Tnfrsf16,神经生长因子,nerve growth factor receptor (TNFR ...

Mouse HEK293 Cells
NGFR/p75NTR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25 kDa and the accession number is Q9Z0W1.
TMPY-02588 NGFR/p75NTR Protein, Mouse, Recombinant (hFc)

p75NGFR,RP23-67E18.6,p75,p75NTR,LNGFR,神经生长因子,Tnfrsf16,ne...

Mouse HEK293 Cells
NGFR/p75NTR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.6 kDa and the accession number is Q9Z0W1.
TMPH-03357 S100A4 Protein, Rat, Recombinant (His & Myc)

P9K,Metastasin,Placental calcium-binding protein,S100 calciu...

Rat E. coli
S100A4 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 18.6 kDa and the accession number is P05942.
TMPY-02615 NGFR/p75NTR Protein, Human, Recombinant (His)

p75(NTR),TNFRSF16,神经生长因子,p75NTR,nerve growth factor...

Human HEK293 Cells
NGFR/p75NTR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25 kDa and the accession number is P08138.
TMPJ-00883 EGR1 Protein, Human, Recombinant (His)

zinc finger protein 225,NGFI-A,Zif268,Early growth response ...

Human E. coli
EGR-1 belongs to the EGR family of C2H2-type zinc finger proteins. It is a nuclear protein and functions as a transcriptional regulator. EGR-1 recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site).The products of target genes it activates are required for differentiation and mitogenesis. Studies suggest this is a tumor suppressor gene. EGR-1 has a distinct pattern of expression in the brain, and its induction has been shown to be associated with neuronal activity. Several studies su...
TMPH-02742 Klk1b22 Protein, Mouse, Recombinant (His & SUMO)

Klk1b22,Glandular kallikrein K22,Beta-NGF-endopeptidase,Kall...

Mouse E. coli
Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Klk1b22 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 41.8 kDa and the accession number is P15948.
TMPK-00735 CXCL13/BCA-1 Protein, Mouse, Recombinant (His)

ANGIE,BLR1L,ANGIE2,BLC,SCYB13,BCA1,BCA-1

Mouse HEK293 Cells
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve ligation (SNL) model of neuropathic pain, CXCL13 was persistently upregulated in spinal cord neurons after SNL, resulting in spinal astrocyte activation via CXCR5 in mice. CXCL13/BCA-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The pred...
TMPY-04069 Neurotrophin 3 Protein, Human, Recombinant

NGF2,HDNF,NT-3,neurotrophin 3,NGF-2,NT3

Human E. coli
NTF3 (Neurotrophin 3) is a Protein Coding gene. The protein encoded by this gene is a member of the neurotrophin family, that controls the survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. NTF3 is a key mediator of neuronal development during the early neurogenic period. NTF3 is a novel target gene of POU3F2 and that the POU3F2/NTF3 pathway plays a role in the process of neuronal differentiation. ...
TMPJ-00135 BDNF Protein, Human/Murine/Rat, Recombinant

BDNF,Abrineurin,Brain-Derived Neurotrophic Factor

Human,Mouse,Rat E. coli
Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF, NT-3 and NT-4, BDNF binds with high affinity to the TrkB kinase receptor. It also binds with the LNGFR (for low-affinity nerve growth factor receptor, also known as p75). BDNF promotes the survival, growth and differentiation of neurons. It serves as a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. ...
TMPJ-01471 Activin A Protein, Human, Mouse, Rat, Cynomolgus, Rhesus, Recombinant

Activin A,INHBA,Inhibin beta A chain,Inhibin β A chain

Human/Mouse/Rat HEK293 Cells
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell developm...
TMPK-00774 TrkA Protein, Human, Recombinant (aa 33-417, His)

TrkAI,TrkA I,Trk-A,TRKA,NTRK1,MTC,TRK,TrkA-I

Human HEK293 Cells
TrkA, a tyrosine kinase receptor, is an essential component of the nerve growth factor (NGF) response pathway. The binding of NGF to the receptor induces receptor autophosphorylation and activation of intracellular signaling pathways, resulting in diverse biological effects.
TMPY-03053 Ezrin Protein, Human, Recombinant (His)

HEL-S-105,CVL,VIL2,CVIL,ezrin

Human E. coli
VIL2, also known as villin-2, belongs to the ERM protein family. It is expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. VIL2 contains 1 FERM domain and may be involved in connections of major cytoskel
TMPY-03963 CALCB Protein, Human, Recombinant (mFc)

CGRP-II,calcitonin-related polypeptide β,calcitonin-related ...

Human HEK293 Cells
CALCB, also known as CGPR and calcitonin 2, belongs to the calcitonin family. CALCB is a calcitonin (CT) peptide which may play a role in the mediation of human inflammatory diseases. It is highly expressed in the skin, blood, and cerebrospinal fluid. CGRP immunolabeling (IL) was detected in epidermal keratinocytes at levels that were especially high and widespread in the skin of humans from locations afflicted with postherpetic neuralgia (PHN) and complex region pain syndrome type 1 (CRPS), of ...
TMPH-03369 SEMA3A Protein, Rat, Recombinant (His)

Semaphorin III,Sema3a,Semaphorin-3A

Rat E. coli
May be involved in guiding growing axons towards their targets by forming a molecular boundary that instructs axons to engage in the formation of specific nerve tracts. Binds to neuropilin. Involved in the development of the olfactory system and in neuronal control of puberty. SEMA3A Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 90.6 kDa and the accession number is Q63548.
TMPY-02579 NRN1 Protein, Human, Recombinant (His)

NRN,dJ380B8.2,MGC44811,neuritin 1

Human Baculovirus Insect Cells
Neuritin 1 (NRN1) is a member of the neuritin family. Neuritin is a glycosylphosphatidylinositol-anchored protein induced by neural activity. It is expressed in postmitotic-differentiating neurons of the developing nervous system and a population of small-diameter neurons in the dorsal root ganglia and was anterogradely and retrogradely transported. Neuritin message is induced by neuronal activity and by the activity-regulated neurotrophins BDNF, nerve growth factor (NGF), and NT-3. Purified rec...
TMPY-02106 GAP43 Protein, Human, Recombinant (His)

B-50,PP46,growth associated protein 43

Human HEK293 Cells
Neuromodulin, also known as Axonal membrane protein GAP-43, Growth-associated protein 43, Neural phosphoprotein B-5, pp46 and GAP43, is a cell membrane protein which belongs to theneuromodulin family. Neuromodulin / GAP43 contains oneIQ domain. Neuromodulin / GAP43 is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Neuromodulin / GAP43 is involved in neurite outgrowth, a crucial process for the differentiation of n...
TMPJ-01016 INHBC Protein, Human, Recombinant (N-His)

Activin Beta-C Chain,INHBC,Inhibin β C Chain,Activin β-C Cha...

Human E. coli
Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins,Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary...
TMPK-01065 SEZ6 Protein, Mouse, Recombinant (His)

BSRP-C,SEZ-6,BSRPC,SEZ6

Mouse HEK293 Cells
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is...
TMPH-01258 DAG1 Protein, Human, Recombinant (His & Myc)

Dystrophin-associated glycoprotein 1,Dystroglycan,Dystroglyc...

Human Baculovirus Insect Cells
The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.; Extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Also acts as a receptor for laminin LAMA5.; Transmembra...
TMPK-00541 SEZ6 Protein, Cynomolgus, Recombinant (His)

SEZ-6,BSRPC,BSRP-C,SEZ6

Cynomolgus HEK293 Cells
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weig...
TMPK-00998 SEZ6 Protein, Human, Recombinant (His)

BSRPC,BSRP-C,SEZ-6,SEZ6

Human HEK293 Cells
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is...
TMPK-00017 CXCL13/BCA-1 Protein, Human, Recombinant (hFc)

BCA1,BLR1L,BLC,SCYB13,ANGIE2,BCA-1,ANGIE

Human HEK293 Cells
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve ligation (SNL) model of neuropathic pain, CXCL13 was persistently upregulated in spinal cord neurons after SNL, resulting in spinal astrocyte activation via CXCR5 in mice. CXCL13/BCA-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The pred...
TMPH-02637 Embigin Protein, Mouse, Recombinant (His)

Emb,Gp70,Teratocarcinoma glycoprotein Gp-70,Embigin

Mouse E. coli
Plays a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane. Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. Embig...
TMPH-01530 INHBA Protein, Human, Recombinant (His & SUMO)

Activin beta-A chain,INHBA,Inhibin beta A chain,Erythroid di...

Human E. coli
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of a...
TMPH-03400 SLC17A6 Protein, Rat, Recombinant (His)

Slc17a6,Vesicular glutamate transporter 2,Solute carrier fam...

Rat P. pastoris (Yeast)
Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. Involved in the regulation of retinal hyaloid vessel regression during postnatal development. May also play a role in the endocrine glutamatergic system of other tissues such as pineal gland and pancreas. SLC17A6 Protein, Rat, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 11.1 kDa an...
TMPY-03216 GMF beta/GMFB Protein, Human, Recombinant

GMF β/GMFB,glia maturation factor, β,glia maturation factor,...

Human E. coli
GMFB is a nerve growth factor which belongs to the actin-binding proteins ADF family, GMF subfamily. GMFB is involved in nervous system development, angiogenesis and immune function. It is especially crucial for the nervous system. GMFB causes brain cell differentiation, stimulates neural regeneration and inhibits tumor cell proliferation. It contains 1 ADF-H domain and is phosphorylated after phorbol ester stimulation. GMFB overexpression in astrocytes results in the increase of BDNF production...
TMPK-00997 SEZ6 Protein, Human, Recombinant (hFc)

SEZ-6,BSRP-C,SEZ6,BSRPC

Human HEK293 Cells
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is...
TMPJ-00100 Artemin Protein, Human, Recombinant

ARTN,Artemin,EVN,Enovin,Neublastin

Human E. coli
Human Artemin is a GDNF family ligand that is distantly related to the TGF-β superfamily of molecules. It is synthesized as a preproprotein, and contains a variable length pre-, or signal sequence, plus a 68 amino acid (aa) proregion and a 113 aa mature segment. Following synthesis and proteolytic processing, mature ARTN is secreted as a presumably glycosylated, 28 kDa disulfide-linked homodimer that contains three intrachain disulfide bonds and the typical TGF-β signature cysteine-knot motif. I...
TMPJ-00024 GMF beta/GMFB Protein, Human, Recombinant (His)

GMF-β,GMF-beta,GMFB,Glia maturation factor beta,Glia maturat...

Human E. coli
Glia maturation factor beta (GMFB) contains a ADF-H domain,which is a member of the actin-binding proteins ADF family, GMF subfamily. It is a nerve growth factor implicated in nervous system development, angiogenesis and immune function. GMFB causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells. It is phosphorylated after phorbol ester stimulation, and is crucial for the nervous system. GMFB overexpression in astrocytes results...
TMPJ-00892 TAC1 Protein, Human, Recombinant (His)

PPT,Protachykinin-1,TAC1

Human E. coli
Protachykinin-1(TAC1) is a secreted protein and belongs to the tachykinin family. TAC1 is encoded by the TAC1 gene. This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretag...
TMPK-00996 SEZ6 Protein, Human, Recombinant (His & Avi), Biotinylated

BSRPC,BSRP-C,SEZ6,SEZ-6

Human HEK293 Cells
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predi...
TMPK-00734 CXCL13/BCA-1 Protein, Mouse, Recombinant (hFc)

ANGIE,ANGIE2,BCA-1,BLR1L,BLC,BCA1,SCYB13

Mouse HEK293 Cells
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve ligation (SNL) model of neuropathic pain, CXCL13 was persistently upregulated in spinal cord neurons after SNL, resulting in spinal astrocyte activation via CXCR5 in mice. CXCL13/BCA-1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The pred...
TMPK-00018 CXCL13/BCA-1 Protein, Human, Recombinant (His & Sumo)

BLC,SCYB13,ANGIE,ANGIE2,BCA-1,BLR1L,BCA1

Human E. coli
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve ligation (SNL) model of neuropathic pain, CXCL13 was persistently upregulated in spinal cord neurons after SNL, resulting in spinal astrocyte activation via CXCR5 in mice. CXCL13/BCA-1 Protein, Human, Recombinant (His & Sumo) is expressed in E. coli expression system with N-His-Sum...
TMPY-01695 CASPR2 Protein, Mouse, Recombinant (His)

5430425M22Rik,Caspr2,contactin associated protein-like 2,mKI...

Mouse HEK293 Cells
CNTNAP2/CASPR2 is a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. CNTNAP2/CASPR2 is localized at the juxtaparanodes of myelinated axons, and media...
TMPJ-00813 QDPR Protein, Human, Recombinant (His)

Dihydropteridine Reductase,QDPR,DHPR,HDHPR,Quinoid Dihydropt...

Human HEK293 Cells
Dihydropteridine reductase, also known as HDHPR and Quinoid dihydropteridine reductase, QDPR and DHPR, belongs to the short-chain dehydrogenases/reductases (SDR) family. QDPR exists as a homodimer. QDPR is part of the pathway that recycles a substance called tetrahydrobiopterin, also known as BH4 and tryptophan hydroxylases. The regeneration of this substance is critical for the proper processing of several other amino acids in the body. Tetrahydrobiopterin also helps produce certain chemicals i...
TMPJ-01015 INHBC Protein, Human, Recombinant (C-His)

Activin β-C Chain,Activin Beta-C Chain,Inhibin β C Chain,INH...

Human HEK293 Cells
Inhibin beta C chain, also known as activin beta-C chain and INHBC, belongs to the TGF-beta family. INHBC forms a homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only. Inhibins/activins regulates many physiological processes, such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell ...
TMPY-03852 Dopamine beta-Hydroxylase Protein, Human, Recombinant (His)

dopamine β-hydroxylase (dopamine β-monooxygenase),Dopamine β...

Human HEK293 Cells
DBH is a 29 kDa copper-containing oxygenase. It can be detected in noradrenergic nerve terminals of the central and peripheral nervous systems, and is also expressed in chromaffin cells of the adrenal medulla. DBH contains our identical subunits, and its activity requires ascorbate as a cofactor. It functions in in the synthesis of small-molecule neurotransmitters that is membrane-bound, making norepinephrine the only transmitter synthesized inside vesicles. DBH has been shown to be associated ...
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重组蛋白

NGF Protein, Human, Recombinant (E. colli)
Cat.No: TMPJ-01469
Species: Mouse
Expression System: E. coli
NGF Protein, Human, Recombinant (HEK293)
Cat.No: TMPY-06985
Species: Human
Expression System: HEK293 Cells
pro-Beta NGF Protein, Human, Recombinant
Cat.No: TMPJ-01468
Species: Human
Expression System: E. coli
NGF Protein, Human, Recombinant
Cat.No: TMPY-01010
Species: Human
Expression System: CHO Cells
NGFR/p75NTR Protein, Human, Recombinant (hFc)
Cat.No: TMPY-02614
Species: Human
Expression System: HEK293 Cells
NGF Protein, Mouse, Recombinant
Cat.No: TMPY-01402
Species: Mouse
Expression System: CHO Cells
NGF Protein, Pig, Recombinant (His & SUMO)
Cat.No: TMPH-03102
Species: Sus scrofa (Pig)
Expression System: E. coli
NGFR/p75NTR Protein, Rabbit, Recombinant (His)
Cat.No: TMPY-04646
Species: Rabbit
Expression System: HEK293 Cells
Neurotrophin 3 Protein, Rat, Recombinant (His & Myc)
Cat.No: TMPH-03341
Species: Rat
Expression System: E. coli
Neurotrophin 3 Protein, Human, Recombinant (His)
Cat.No: TMPH-01769
Species: Human
Expression System: E. coli
NGFR/p75NTR Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPY-06973
Species: Cynomolgus
Expression System: HEK293 Cells
NGFR/p75NTR Protein, Rat, Recombinant (His)
Cat.No: TMPY-06959
Species: Rat
Expression System: HEK293 Cells
NGFR/p75NTR Protein, Rabbit, Recombinant (hFc)
Cat.No: TMPY-04831
Species: Rabbit
Expression System: HEK293 Cells
NGFR/p75NTR Protein, Mouse, Recombinant (His)
Cat.No: TMPY-02541
Species: Mouse
Expression System: HEK293 Cells
NGFR/p75NTR Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-02588
Species: Mouse
Expression System: HEK293 Cells
S100A4 Protein, Rat, Recombinant (His & Myc)
Cat.No: TMPH-03357
Species: Rat
Expression System: E. coli
NGFR/p75NTR Protein, Human, Recombinant (His)
Cat.No: TMPY-02615
Species: Human
Expression System: HEK293 Cells
EGR1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00883
Species: Human
Expression System: E. coli
Klk1b22 Protein, Mouse, Recombinant (His & SUMO)
Cat.No: TMPH-02742
Species: Mouse
Expression System: E. coli
CXCL13/BCA-1 Protein, Mouse, Recombinant (His)
Cat.No: TMPK-00735
Species: Mouse
Expression System: HEK293 Cells
Neurotrophin 3 Protein, Human, Recombinant
Cat.No: TMPY-04069
Species: Human
Expression System: E. coli
BDNF Protein, Human/Murine/Rat, Recombinant
Cat.No: TMPJ-00135
Species: Human,Mouse,Rat
Expression System: E. coli
Activin A Protein, Human, Mouse, Rat, Cynomolgus, Rhesus, Recombinant
Cat.No: TMPJ-01471
Species: Human/Mouse/Rat
Expression System: HEK293 Cells
TrkA Protein, Human, Recombinant (aa 33-417, His)
Cat.No: TMPK-00774
Species: Human
Expression System: HEK293 Cells
Ezrin Protein, Human, Recombinant (His)
Cat.No: TMPY-03053
Species: Human
Expression System: E. coli
CALCB Protein, Human, Recombinant (mFc)
Cat.No: TMPY-03963
Species: Human
Expression System: HEK293 Cells
SEMA3A Protein, Rat, Recombinant (His)
Cat.No: TMPH-03369
Species: Rat
Expression System: E. coli
NRN1 Protein, Human, Recombinant (His)
Cat.No: TMPY-02579
Species: Human
Expression System: Baculovirus Insect Cells
GAP43 Protein, Human, Recombinant (His)
Cat.No: TMPY-02106
Species: Human
Expression System: HEK293 Cells
INHBC Protein, Human, Recombinant (N-His)
Cat.No: TMPJ-01016
Species: Human
Expression System: E. coli
SEZ6 Protein, Mouse, Recombinant (His)
Cat.No: TMPK-01065
Species: Mouse
Expression System: HEK293 Cells
DAG1 Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01258
Species: Human
Expression System: Baculovirus Insect Cells
SEZ6 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-00541
Species: Cynomolgus
Expression System: HEK293 Cells
SEZ6 Protein, Human, Recombinant (His)
Cat.No: TMPK-00998
Species: Human
Expression System: HEK293 Cells
CXCL13/BCA-1 Protein, Human, Recombinant (hFc)
Cat.No: TMPK-00017
Species: Human
Expression System: HEK293 Cells
Embigin Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02637
Species: Mouse
Expression System: E. coli
INHBA Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-01530
Species: Human
Expression System: E. coli
SLC17A6 Protein, Rat, Recombinant (His)
Cat.No: TMPH-03400
Species: Rat
Expression System: P. pastoris (Yeast)
GMF beta/GMFB Protein, Human, Recombinant
Cat.No: TMPY-03216
Species: Human
Expression System: E. coli
SEZ6 Protein, Human, Recombinant (hFc)
Cat.No: TMPK-00997
Species: Human
Expression System: HEK293 Cells
Artemin Protein, Human, Recombinant
Cat.No: TMPJ-00100
Species: Human
Expression System: E. coli
GMF beta/GMFB Protein, Human, Recombinant (His)
Cat.No: TMPJ-00024
Species: Human
Expression System: E. coli
TAC1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00892
Species: Human
Expression System: E. coli
SEZ6 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-00996
Species: Human
Expression System: HEK293 Cells
CXCL13/BCA-1 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPK-00734
Species: Mouse
Expression System: HEK293 Cells
CXCL13/BCA-1 Protein, Human, Recombinant (His & Sumo)
Cat.No: TMPK-00018
Species: Human
Expression System: E. coli
CASPR2 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-01695
Species: Mouse
Expression System: HEK293 Cells
QDPR Protein, Human, Recombinant (His)
Cat.No: TMPJ-00813
Species: Human
Expression System: HEK293 Cells
INHBC Protein, Human, Recombinant (C-His)
Cat.No: TMPJ-01015
Species: Human
Expression System: HEK293 Cells
Dopamine beta-Hydroxylase Protein, Human, Recombinant (His)
Cat.No: TMPY-03852
Species: Human
Expression System: HEK293 Cells
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Cat. No. Product Name Target Signaling Pathways
T23983 Deutetrabenazine metabolite M4

SD-1018,Deuterated monohydroxy tetrabenazine,D6-tetrabenazine metabolite M4

Deutetrabenazine metabolite M4 is believed to be related to its effect as a reversible depletion of monoamines from nerve terminals. The major circulating metabolites of Deutetrabenazine, are reversible inhibitors of VMAT2, resulting in decreased uptake
TMIH-0086 Amifampridine-d3 2HCl

Amifampridine-d3 2HCl 是 Amifampridine 2HCl 的氘代化合物。Amifampridine 2HCl 的 CAS 号为 54-96-6。Amifampridine 可用于罕见肌肉疾病的研究。
TMIJ-0377 Thiamine Hydrochloride-13C4

Thiamine Hydrochloride-13C4 是 Thiamine Hydrochloride 的 13C 的标记化合物。Thiamine Hydrochloride 的 CAS 号为 67-03-8。Thiamine hydrochloride 是一种必需的微量营养素,是许多中枢代谢酶的辅因子。
T69600 Spermidine-d6

Spermidine-d6 is intended for use as an internal standard for the quantification of spermidine by GC- or LC-MS. Spermidine is an endogenous polyamine. It is formed from putrescine by spermidine synthase. Spermidine (25 µM) inhibits the activity of the human inward-rectifying potassium channel Kir2.3 in a patch-clamp assay. It induces autophagy in HeLa cells when used at a concentration of 100 µM and increases the lifespan of D. melanogaster, yeast, and C. elegans. Spermidine (30 mM in the drinki...
TMIJ-0114 Vardenafil-d5

Vardenafil-d5 是 Vardenafil 的氘代化合物。Vardenafil 的 CAS 号为 224785-90-4。Vardenafil 是选择性、高效的、具有口服活性的磷酸二酯酶5抑制剂,IC50=0.7 nM。它能够非竞争性地抑制环磷酸鸟苷水解,从而提高 cGMP 水平。它对 PDE1 (180 nM),PDE6 (11 nM),PDE2,PDE3,PDE4 (>1000 nM) 具有选择性。它可用于研究勃起功能障碍。

同位素标记化合物

Deutetrabenazine metabolite M4
Cat.No: T23983
Synonym: SD-1018,Deuterated monohydroxy tetrabenazine,D6-tetrabenazine metabolite M4
Target:
Amifampridine-d3 2HCl
Cat.No: TMIH-0086
Synonym:
Target:
Thiamine Hydrochloride-13C4
Cat.No: TMIJ-0377
Synonym:
Target:
Spermidine-d6
Cat.No: T69600
Synonym:
Target:
Vardenafil-d5
Cat.No: TMIJ-0114
Synonym:
Target:
TargetMol Loading
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