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TMPY-02238
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MAD2L1 Protein, Human, Recombinant (His)
MAD2 mitotic arrest deficient-like 1 (yeast),HSMAD2...
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Human
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E. coli
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Mitotic spindle assembly checkpoint protein MAD2A, also known as HsMAD2, Mitotic arrest deficient 2-like protein 1, MAD2-like protein 1, MAD2L1, and MAD2, is a nucleus and cytoplasm protein that belongs to the MAD2 family. MAD2L1 is a component of the spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle atta... |
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TMPH-00841
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SMARCA4 Protein, Human, Recombinant (His)
ATP-dependent helicase SMARCA4,Mitotic growth and t...
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Human
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E. coli
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SMARCA4 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 37.1 kDa and the accession number is P51532. |
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TMPH-02217
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SMARCA4 Protein, Human, Recombinant (His)
Transcription activator BRG1,Protein brahma homolog 1,SWI/SN...
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Human
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P. pastoris (Yeast)
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Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor compl... |
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TMPY-04125
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PTP1B Protein, Human, Recombinant (His)
protein tyrosine phosphatase, non-receptor type 1,PTP1B,PTPN...
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Human
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E. coli
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PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1B contains 1 tyrosine-protein p... |
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TMPY-04025
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CEP57 Protein, Human, Recombinant (GST)
MVA2,PIG8,TSP57,centrosomal protein 57kDa
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Human
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E. coli
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CEP57 is a centrosomal protein and is involved in nucleating and stabilizing microtubules. CEP57 was initially identified as a regulator of centriole overduplication in an RNA interference screen. There is a link between altered microenvironmental signaling cues such as FGF-2 overexpression and mitotic instability and provide a rationale for the therapeutic targeting of the FGF-2/FGFR1/CEP57 axis in prostate cancer. CEP57 is involved in intracellular transport processes, and its overexpression c... |
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TMPH-01592
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KIF18B Protein, Human, Recombinant (His & Myc)
Kinesin-like protein KIF18B,KIF18B
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Human
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E. coli
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In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules. |
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TMPH-01704
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RAE1 Protein, Human, Recombinant (GST)
Rae1 protein homolog,mRNA-associated protein mrnp 41,mRNA ex...
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Human
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E. coli
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Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. RAE1 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 68.0 kDa and the accession number is P78406. |
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TMPK-00618
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FcRH5/FcRL5 Protein, Human, Recombinant (His)
FcR-like protein 5,CD307,BXMAS1,FcRH5,IFGP5,CD307e,FcRL5
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Human
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HEK293 Cells
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FcRH5 is a cell surface marker enriched on malignant plasma cells when compared to other hematologic malignancies and normal tissues. DFRF4539A is an anti-FcRH5 antibody-drug conjugated to monomethyl auristatin E (MMAE), a potent anti-mitotic agent. FcRH5/FcRL5 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 92.38 kDa and the accession number is AAK93971. |
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TMPH-01703
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CDC25C Protein, Human, Recombinant (His)
Dual specificity phosphatase Cdc25C,M-phase inducer phosphat...
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Human
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E. coli
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Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity. CDC25C Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 57.4 kDa and the accession number is P30307. |
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TMPK-00619
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FcRH5/FcRL5 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
IFGP5,CD307,FCRH5MGC119593,FLJ00397,DKFZp667E2019,BXMAS1MGC1...
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Human
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HEK293 Cells
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FcRH5 is a cell surface marker enriched on malignant plasma cells when compared to other hematologic malignancies and normal tissues. DFRF4539A is an anti-FcRH5 antibody-drug conjugated to monomethyl auristatin E (MMAE), a potent anti-mitotic agent. FcRH5/FcRL5 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 92.38 kDa and the accession number is AAK93971. |
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TMPK-01039
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FcRH5/FcRL5 Protein, Mouse, Recombinant (His)
CD307e,FcRL5,BXMAS1MGC119592,IFGP5,FcRH5,BXMAS1,CD307,DKFZp6...
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Mouse
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HEK293 Cells
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FcRH5 is a cell surface marker enriched on malignant plasma cells when compared to other hematologic malignancies and normal tissues. DFRF4539A is an anti-FcRH5 antibody-drug conjugated to monomethyl auristatin E (MMAE), a potent anti-mitotic agent. FcRH5/FcRL5 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 53.7 kDa and the accession number is Q68SN8-1. |
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TMPH-01081
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CHMP7 Protein, Human, Recombinant (His)
Charged multivesicular body protein 7,Chromatin-modifying pr...
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Human
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E. coli
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ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway. CHMP7 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 56.9 kDa and the accession number is Q8WUX9. |
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TMPK-01145
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FcRH5/FcRL5 Protein, Human, Recombinant (His & Avi), Biotinylated
CD307,FcRL5,FcR-like protein 5,FCRH5MGC119593,DKFZp667F216,B...
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Human
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HEK293 Cells
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FcRH5 is a cell surface marker enriched on malignant plasma cells when compared to other hematologic malignancies and normal tissues. DFRF4539A is an anti-FcRH5 antibody-drug conjugated to monomethyl auristatin E (MMAE), a potent anti-mitotic agent. FcRH5/FcRL5 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 94.19 kDa and the accession number is Q96RD9-1. |
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TMPH-03438
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CHS1 Protein, S. cerevisiae, Recombinant (His)
CHS1,Chitin-UDP acetyl-glucosaminyl transferase 1,Chitin syn...
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Saccharomyces cerevisiae
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E. coli
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Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer. Required for mitotic division septum formation during adverse conditions. CHS1 Protein, S. cerevisiae, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 26.6 kDa and the accession number is P08004. |
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TMPH-02884
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CTDP1 Protein, Mouse, Recombinant (His & Myc)
Fcp1,Ctdp1,RNA polymerase II subunit A C-terminal domain pho...
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Mouse
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E. coli
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Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation. CTDP1 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The p... |
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TMPY-04558
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NEK7 Protein, Human, Recombinant (His & GST)
NIMA-related kinase 7
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Human
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Baculovirus Insect Cells
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NIMA (never in mitosis gene a)-related kinase 7, NEK7 belongs to the NIMA subfamily, NEK Ser/Thr protein kinase family, protein kinase superfamily. NEKs (NIMA-related kinases) are mammalian serine/threonine (Ser/Thr) protein kinases structurally related to Aspergillus NIMA (Never in Mitosis, gene A), which plays essential roles in mitotic signaling. NEKs share an amino-terminal catalytic domain related to NIMA, an Aspergillus kinase involved in the control of several aspects of mitosis, and dive... |
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TMPY-03442
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MOB4A/MOB1B Protein, Human, Recombinant (GST)
MOB kinase activator 1B,MOBKL1A,MATS2,MOB4A
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Human
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E. coli
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MST1 and MST2 are the mammalian Ste2-related protein kinases most closely related to Drosophila Hippo, a major regulator of cell proliferation and survival during development. Overexpression of MST1 or MST2 in mammalian cells is proapoptotic. MST1 and MST2 activity increase during mitosis, especially in nocodazole-arrested mitotic cells, where these kinases exhibit an increase in both abundance and activation. MST1 and MST2 also can be activated nonphysiologically by okadaic acid or H2O2. The MO... |
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TMPJ-01436
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MKI67 Protein, Human, Recombinant (GST)
Ki-67,Antigen Ki67,MKI67,KIA,antigen KI-67,MIB-1,MIB-,Ki67,P...
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Human
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E. coli
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MKI67 also also known as Ki67, is a 350-400 kDa nuclear protein that belongs to a molecular group comprised of mitotic chromosome-associated proteins. MKI67 contains 1 FHA domain and plays a key role in cell proliferation. MKI67 is contextually expressed, being potentially found in all cells that are not in the Go phase of the cell cycle. Thus, MKI67 qualifies as a cell proliferation marker. It is also associated with ribosomal RNA transcription. Inactivation of antigen MKI67 leads to inhibition... |
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TMPJ-00465
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PTP1C Protein, Human, Recombinant (His)
HCP,Hematopoietic Cell Protein-Tyrosine Phosphatase,SH-PTP1,...
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Human
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E. coli
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Protein-Tyrosine Phosphatase 1C (PTP1C) belongs to the protein-tyrosine phosphatase family.which is known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1C is highly expressed in leukocyte cell type. It contains two SH2 domains and one tyrosine-protein phosphatase domain. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against inter... |
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TMPH-02304
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Vasohibin-2/VASH2 Protein, Human, Recombinant (His & SUMO)
Vasohibin-2,VASH2,Vasohibin-like protein,Tubulinyl-Tyr carbo...
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Human
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E. coli
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Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning. Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis. Plays a role in axon formation. Vasohibin-2/VASH2 Protein, Human,... |
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TMPJ-00972
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CDKN1B Protein, Human, Recombinant (His)
KIP1,CDKN1B,Cyclin-Dependent Kinase Inhibitor p27,Cyclin-Dep...
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Human
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E. coli
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Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B) is a Kinesin-related motor protein necessary for mitotic spindle assembly and chromosome segregation. CDKN1B is expressed in all tissues with highest levels observed in skeletal muscle. CDKN1B is a potent inhibitor of Cyclin E- and Cyclin A-CDK2 complexes. CDKN1B forms a complex with Cyclin Type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. In addition, CDKN1B acts as an inhibitor or an ... |
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TMPY-03296
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SHP-1 Protein, Mouse, Recombinant (aa 207-597, His & GST)
SH-PTP1,Hcph,70Z-SHP,Ptp1C,protein tyrosine phosphatase, non...
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Mouse
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Baculovirus Insect Cells
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PTPN6 is an enzyme that belongs to the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of PTPN6 contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of PTPN6 with its substrates. PTPN6 is expressed primarily in hematopoietic cells, and functions as an ... |
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TMPJ-00960
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TMPO Protein, Human, Recombinant (His)
Thymopoietin-Related Peptide Isoforms β/γ,Splenin,TMPO,TP,TP...
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Human
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E. coli
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Thymopentin is a member of the LEM family. Thymopentin is expressed in many tissues, highly in the adult thymus and fetal liver. The N-terminal contains two structurally independent domains, LEM domain and LEM-like domain. The C-terminal domain forms a four-stranded coiled coil. Thymopentin may be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. It is associated with T-cell development and function. Meantime, Thymopentin plays an important role, to... |
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TMPH-00536
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Epstein-Barr virus (strain AG876) EBNA2 Protein (His & Myc)
Epstein-Barr nuclear antigen 2,EBNA2
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EBV
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P. pastoris (Yeast)
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Plays a key role in the activation of the host resting B-cell and stimulation of B-cell proliferation. Acts by up-regulating the expression of viral EBNA1-6, LMP1, LMP2A and LMP2B genes, as well as several host genes including CD21, CD23 and MYC. Activates transcription by acting as an adapter molecule that binds to cellular sequence-specific DNA-binding proteins such as host CBF1, SMARCB1 and SPI1. Once EBNA2 is near promoter sites, its acidic activating domain recruits basal and activation-ass... |
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TMPY-04547
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PBK/TOPK Protein, Human, Recombinant (His)
HEL164,Nori-3,CT84,TOPK,PDZ binding kinase,SPK
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Human
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Baculovirus Insect Cells
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PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the characteristic protein kinase subdomains and a C-terminal PDZ-binding T/SXV motif. PBK is expressed in the testis restrictedly expressed in outer cell layer of seminiferous tubules, as well as placenta. PBK may be enrolled in the activation of lymphoid cells and support testicular fun... |
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TMPH-02846
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BICD2 Protein, Mouse, Recombinant (GST)
Bicd2,Kiaa0699,Bic-D 2,Protein bicaudal D homolog 2
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Mouse
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E. coli
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Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (... |
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TMPH-01526
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KMT2E Protein, Human, Recombinant (His & Myc)
Inactive histone-lysine N-methyltransferase 2E,Myeloid/lymph...
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Human
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E. coli
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Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Also acts as an important cell cycle regulator, participating in cell cycle r... |
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TMPY-04443
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NEK3 Protein, Mouse, Recombinant (His & GST)
NIMA-related kinase 3
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Mouse
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Baculovirus Insect Cells
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NEK3 (NIMA (never in mitosis gene a)-related expressed kinase 3), contains 1 protein kinase domain and is a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. Members of the NEK family of protein kinases share high amino acid homology with NIMA (never in mitosis gene a). NEK3 differs from other NimA family members in that it is not the cell cycle-regulated and is found primarily in the cytoplasm. It is activated by prolactin stimulation, leading to phosphorylatio... |
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TMPY-02763
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DEP-1 Protein, Human, Recombinant (aa 997-1337, His)
HPTPeta,SCC1,protein tyrosine phosphatase, receptor type, J,...
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Human
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E. coli
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DEP1 / PTPRJ (Receptor-type tyrosine-protein phosphatase eta) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. DEP1 / PTPRJ possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-... |
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TMPJ-00936
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CCND2 Protein, Human, Recombinant (His)
G1/S-specific cyclin-D2,CCND2
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Human
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E. coli
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CCND2，also known as G1/S-specific cyclin-D2，is a member of the highly conserved cyclin family. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. CCND2 is involved in a number of fundamental biological processes such ... |
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TMPH-01621
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BRCC3 Protein, Human, Recombinant (His & SUMO)
BRCC36,CXorf53,C6.1A,BRCC3,BRCA1/BRCA2-containing complex su...
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Human
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E. coli
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Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, anta... |
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TMPY-02399
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TRF1 Protein, Human, Recombinant (His)
TRF,telomeric repeat binding factor (NIMA-interacting) 1,hTR...
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Human
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Baculovirus Insect Cells
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Telomeric repeat binding factor 1 (TRF1), also known as TERF1, the shelterin complex, which modulates the telomere structures. TRF1 protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Pin2/TRF1 was originally identified as a protein bound to telomeric DNA (TRF1) and as a protein involved in mitotic regulation (Pin2). Pin2/TRF1 negatively regulates telomere length and importantly, its function is tightly regulated during the cell ... |
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TMPY-03397
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TPPP3 Protein, Human, Recombinant (His)
CGI-38,TPPP3,p25gamma,tubulin polymerization-promoting prote...
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Human
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E. coli
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TPPP3, a member of the Tubulin polymerization-promoting protein family, is an intrinsically unstructured protein that induces tubulin polymerization. TPPP3 is a marker in the developing musculoskeletal system. In tendons, Tppp3 is expressed in cells at the circumference of the developing tendons, likely the progenitors of connective tissues that surround tendons: the tendon sheath, epitenon, and paratenon. Tppp3 is also expressed in forming synovial joints. The onset of Tppp3 expression in joint... |
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TMPH-03753
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MYLK Protein, Human, Recombinant (His)
MYLK,Myosin light chain kinase, smooth muscle,Telokin,Kinase...
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Human
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E. coli
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Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscl... |
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