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Search Results for " metabolism "
Targets Recommended: Mitochondrial Metabolism Mitochondrial Metabolism

492

抑制剂 & 化合物

200

天然产物

23

化合物库

1

TargetMol 试剂盒

172

重组蛋白

24

同位素标记化合物

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Cat. No. Product Name
L2510 脂代谢化合物库

492 compounds
492 个脂代谢相关的化合物集合,可用于高通量和高内涵筛选;
L2550 谷氨酰胺代谢化合物库

565 compounds
565 种谷氨酰胺代谢相关的分子,可以用于高通量和高内涵筛选;
L2130 抗癌细胞代谢库

1268 compounds
1268 种癌细胞代谢相关的生物活性小分子化合物的特有集合,用于肿瘤相关的研究以及抗肿瘤药物的筛选,用于高通量、高内涵筛选;
L5200 抗代谢疾病化合物库

1544 compounds
1544 个代谢疾病相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选;
L2560 代谢化合物库

2320 compounds
2320 种代谢途径相关的化合物,可用于高通量和高内涵筛选。
L2520 糖代谢化合物库

702 compounds
702 种糖代谢相关的化合物,可用于高通量和高内涵筛选;
L2501 人内源代谢化合物库 Plus

1283 compounds
1283种内源性生物活性化合物的独特集合,用于高通量、高内涵筛选。
L2100 抗癌化合物库

7234 compounds
7234 种肿瘤相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选;
L1510 核受体化合物库

531 compounds
531 个核受体作用化合物的独特集合,可用于高通量筛选和高内涵筛选;
L2540 肠道微生物代谢化合物库

614 compounds
614 种肠道微生物代谢物的集合,可以用于高通量和高内涵筛选;
L2400 内分泌激素分子库

784 compounds
784 种与内分泌系统相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选;
L2150 抗癌药物库

3080 compounds
3080 个具有抗癌活性小分子的独特集合,生物活性已经临床前实验证实,可用于高通量、高内涵筛选;
L6130 萜类天然产物库

622 compounds
622 种萜类天然产物的独特集合,可用于高通量筛选和高内涵筛选;
L2160 抗癌活性化合物库

3188 compounds
3188 种具有抗肿瘤活性的化合物的特有集合,用于高通量、高内涵筛选;
L1610 FDA 上市激酶抑制剂库

263 compounds
263种靶向激酶的上市药物集合,用于特定靶向激酶,可用于高通量筛选和高内涵筛选;
L2120 抗癌临床化合物库

2545 compounds
2545 个具有抗癌活性小分子的独特集合,可用于高通量高内涵筛选。
L1120 AMPK靶向分子库

80 compounds
80 个靶向AMPK 的分子集合,可用于高通量和高内涵筛选;
L2110 抗癌上市药物库

1779 compounds
1779 个具有抗癌活性小分子的独特集合,所有化合物都经过了严格的临床前研究和临床试验,由FDA、EMA 或NMPA 批准上市,可用于高通量、高内涵筛选。
L2180 抗肿瘤库Plus

1468 compounds
1468 种抗肿瘤相关、结构新颖的化合物;
L6120 黄酮类天然产物库

514 compounds
514 种黄酮类天然产物的独特集合,可用于高通量筛选和高内涵筛选;
L5300 线粒体靶向库

812 compounds
812 种具有潜在或确定线粒体靶向活性的化合物,以促进针对线粒体的药物研究;
L7100 抗肥胖化合物库

2247 compounds
2247 个抗肥胖化合物的独特集合,可用于高通量筛选和高内涵筛选;
L8500 HIF-1化合物库

1336 compounds
1336 个HIF-1相关小分子的独特集合,可用于缺血性疾病、癌症等相关领域的药物开发和药理研究;

化合物库

脂代谢化合物库
Cat.No: L2510
Compounds: 492
谷氨酰胺代谢化合物库
Cat.No: L2550
Compounds: 565
抗癌细胞代谢库
Cat.No: L2130
Compounds: 1268
抗代谢疾病化合物库
Cat.No: L5200
Compounds: 1544
代谢化合物库
Cat.No: L2560
Compounds: 2320
糖代谢化合物库
Cat.No: L2520
Compounds: 702
人内源代谢化合物库 Plus
Cat.No: L2501
Compounds: 1283
抗癌化合物库
Cat.No: L2100
Compounds: 7234
核受体化合物库
Cat.No: L1510
Compounds: 531
肠道微生物代谢化合物库
Cat.No: L2540
Compounds: 614
内分泌激素分子库
Cat.No: L2400
Compounds: 784
抗癌药物库
Cat.No: L2150
Compounds: 3080
萜类天然产物库
Cat.No: L6130
Compounds: 622
抗癌活性化合物库
Cat.No: L2160
Compounds: 3188
FDA 上市激酶抑制剂库
Cat.No: L1610
Compounds: 263
抗癌临床化合物库
Cat.No: L2120
Compounds: 2545
AMPK靶向分子库
Cat.No: L1120
Compounds: 80
抗癌上市药物库
Cat.No: L2110
Compounds: 1779
抗肿瘤库Plus
Cat.No: L2180
Compounds: 1468
黄酮类天然产物库
Cat.No: L6120
Compounds: 514
线粒体靶向库
Cat.No: L5300
Compounds: 812
抗肥胖化合物库
Cat.No: L7100
Compounds: 2247
HIF-1化合物库
Cat.No: L8500
Compounds: 1336
Cat. No. Product Name Form Specificity Of Inhibition
C0052 Penicillin-Streptomycin-Amphotericin B Solution (100×), Sterile

青霉素-链霉素-两性霉素B三抗溶液(100×),灭菌

Solution in bottle

TargetMol 试剂盒

青霉素-链霉素-两性霉素B三抗溶液(100×),灭菌
Cat.No: C0052
Cat. No. Product Name Target Signaling Pathways
T9372 D-Histidine

Mitochondrial Metabolism Metabolism
D-Histidine 是一种 L-histidine 的对映体。其中 L-histidine 是婴儿必需的氨基酸,是一种线粒体谷氨酰胺转运的抑制剂。
T9777 THP104c

Mitochondrial Metabolism Metabolism
THP104c 是有效的线粒体分裂抑制剂。
T15373 Gboxin

ATPase; Mitochondrial Metabolism Membrane transporter/Ion channel; Metabolism
Gboxin 是一种氧化磷酸化抑制剂,可靶向抑制胶质母细胞瘤生长,还抑制 F0F1 ATP 合成,具有抗肿瘤活性。
T12408 Perhexiline maleate

Others; Mitochondrial Metabolism Metabolism; Others
Perhexiline maleate 是一种口服活性的 CPT1和 CPT2抑制剂,可降低脂肪酸的代谢。Perhexiline maleate 对大鼠心脏和肝脏CPT 1的IC50值分别为77 和 148 μM。
T19428 Mito-TEMPO

Reactive Oxygen Species; Mitochondrial Metabolism Immunology/Inflammation; Metabolism; NF-κB
Mito-TEMPO 是一种线粒体靶向超氧化物歧化酶的模拟物。Mito-TEMPO 可以清除超氧化物和烷基自由基,防止线粒体的氧化、坏死和凋亡。
T14497 BAM 15

OXPHOS; Mitochondrial Metabolism Apoptosis; Metabolism
BAM 15 是一种线粒体质子解偶联剂,也是一种氧化磷酸化解偶联剂。
T15241 ER-000444793

Others; Mitochondrial Metabolism Metabolism; Others
ER-000444793 是一种线粒体通透性转换孔开放抑制剂。它能够抑制 mPTP,IC50=2.8 μM。
T10706 CCI-006

Mitochondrial Metabolism Metabolism
CCI-006 是一种 MLL 重排白血病细胞的选择性抑制剂和化学增敏剂。 它能够抑制线粒体呼吸,造成 MLL-r 白血病细胞亚群中无法克服的线粒体去极化和促凋亡未折叠蛋白反应。
T8734 Choline

Others Others
Choline hydroxide 是一种普遍存在的水溶性营养素,通常与 B 族维生素有关。
T9169 MPP+ iodide

Mitochondrial Metabolism; Autophagy Autophagy; Metabolism
MPP+ iodide 是一种神经毒素 MPTP 的有毒代谢物,也是一种 5-羟色胺转运体 (SERT) 的高亲和力底物。MPP+ iodide 对多巴胺能神经元有毒,可以在动物模型中导致帕金森症。
T9031 MCU-i4

Others; Mitochondrial Metabolism Metabolism; Others
MCU-i4 阻断IP3依赖的线粒体 Ca2+的摄取,是一种新型 MCU 负调节剂,可结合 MICU1 并损害肌肉细胞生长。
T1768 7ACC2

Mitochondrial Metabolism; Monocarboxylate transporter Membrane transporter/Ion channel; Metabolism
7ACC2 是单羧酸盐转运蛋白抑制剂,IC50为 11 nM。它还是线粒体丙酮酸转运的有效抑制剂,可抑制乳酸涌入,通过抑制乳酸通量来发挥抗癌作用。
T4639 Azemiglitazone

MSDC 0602

Mitochondrial Metabolism; mTOR Metabolism; PI3K/Akt/mTOR signaling
Azemiglitazone (MSDC 0602) 是一种 PPARγ 保留的噻唑烷二酮类药物 (TZD),与能够线粒体丙酮酸载体 (MPC) 相互作用并抑制其活性,降低 pparγ 介导的副作用的风险,有用于 2 型糖尿病研究的潜能。
T3713 BAY-876

transporter Metabolism
BAY-876 是口服有效的,选择性的葡萄糖转运蛋白 1 (GLUT1) 抑制剂(IC50= 2 nM)。BAY-876 对 GLUT1 选择性比 GLUT2,GLUT3 和 GLUT4 高(>130 倍)。BAY-876 对糖酵解代谢和卵巢癌生长也有有效的抑制作用。
T2498 Adjudin

AF-2364

Chloride channel; Mitochondrial Metabolism Membrane transporter/Ion channel; Metabolism
Adjudin (AF-2364) 是广泛研究的男性避孕试剂,可通过抑制 NF-κB 通路来减弱小胶质细胞的活化。
T4039 BIBB 515

Others Others
BIBB 515 是口服具有活力的 2,3-氧化角鲨烯环化酶选择性抑制剂,在大鼠和小鼠中的 ED50值分别为 0.2-0.5 mg/kg 和 0.36-33.3 mg/kg (1-5 小时)。它主要利用抑制低密度脂蛋白的产生,从而发挥降脂作用。
T16342 KL1333

NQO1 activator 1

NADPH; Mitochondrial Metabolism Metabolism
KL1333 (NQO1 activator 1) 是口服NAD+调节剂,与 NAD(P)H: 醌氧化还原酶 1 作为底物反应。它改善线粒体脑肌病、乳酸酸中毒和中风样发作成纤维细胞的能量代谢和线粒体功能障碍。它对顺铂诱导的小鼠耳蜗培养耳毒性的保护作用。
T6816 DASA-58

PKM Metabolism
DASA58 是一种有效的丙酮酸激酶M2 (PKM2) 活化剂,其中AC90=680 nM,AC50=38 nM。
T8732 CTPI-2

Others; Mitochondrial Metabolism Metabolism; Others
CTPI-2 是一种特异性线粒体柠檬酸盐载体SLC25A1抑制剂,KD=3.5 μM,具有抗肿瘤作用。它能够抑制糖酵解、PPARγ 及其下游靶点葡萄糖转运蛋白 GLUT4。它阻断非酒精性脂肪性肝炎逆转脂肪变性的显著改变,防止演变为脂肪性肝炎,减少肝脏和脂肪组织中炎性巨噬细胞的浸润,并显著减轻由高脂肪饮食引起的肥胖。
T6834 FCCP

Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone,Trifluoromethoxy carbonylcyanide phenylhydrazone

ATPase; Mitochondrial Metabolism Membrane transporter/Ion channel; Metabolism
FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone) 是一种氧化磷酸化 (OXPHOS) 抑制剂,线粒体质子载体解偶联剂。FCCP 常被用作细胞凋亡诱导剂。
T7093 Rafoxanide

碘醚柳胺,雷复尼特

CDK; Parasite Cell Cycle/Checkpoint; Microbiology/Virology
Rafoxanide 是口服活性水杨酰苯胺类驱虫剂。它作为抗寄生虫剂,可用于控制羊和牛的 Hemonchus 种和 Fasciola 种的感染。
T7837 SR8278

Others Others
SR8278 是竞争性核血红素受体REV-ERB 合成拮抗剂,能够抑制 REV-ERBα 转录活性(EC50:0.47 μM)。它可用于调节生物体内的代谢和研究生物节律。
T40514 ESP 15228

2,2,14,14-Tetramethyl-8-oxopentadecanedioic acid

Others Others
2,2,14,14-Tetramethyl-8-oxopentadecanedioic acid 属于酮类化合物,化合物 II-9。它在心血管疾病、血脂异常、蛋白异常和糖代谢紊乱方面具有研究的价值。
T8308 NL-1

Mitochondrial Metabolism; Autophagy Autophagy; Metabolism
NL-1 是一种mitoNEET 抑制剂,具有抗白血病作用。它抑制 REH 和 REH/Ara-C 细胞生长,IC50分别为 47.35 µM 和 56.26 µM。
T7835 CM10

CM 10

Dehydrogenase Metabolism
CM10是一种有效的乙醛脱氢酶 1A (ALDH1A) 家族选择性抑制剂,对于 ALDH1A1,ALDH1A2 和 ALDH1A3 的IC50分别为 1700、740 和 640 nM。CM 10 可以调节新陈代谢并具有抗癌活性。
T8366 Mitochonic acid 5

MA-5

Mitochondrial Metabolism Metabolism
Mitochonic acid 5 (MA-5) 能够调节线粒体 ATP 合成,可与线粒体结合,并改善肾小管和心肌细胞损伤。
T9232 Mitochondrial fusion promoter M1

Mitochondrial Metabolism Metabolism
Mitochondrial fusion promoter M1 是一种线粒体动态调节剂,能够保持线粒体功能并促进细胞呼吸,减轻心肌缺血/再灌注大鼠的心脏损伤和大脑损伤。
T8500 VLX600

OXPHOS; Mitochondrial Metabolism; Autophagy Apoptosis; Autophagy; Metabolism
VLX600 是一种铁螯合氧化磷酸化抑制剂,是一种细胞渗透性抗癌剂。它通过减少肿瘤细胞中的线粒体氧化磷酸化起作用。
T4441 UK-5099

UK 5099,PF-1005023,UK5099

Others; Mitochondrial Metabolism Metabolism; Others
UK-5099 (PF-1005023) 是一种线粒体丙酮酸转运蛋白 MPC 的抑制剂,通过共价可逆的方式与 MPC2 的 C54 结合来抑制 MPC,有助于丙酮酸通过线粒体内膜的运输。UK-5099 具有抗肿瘤活性。
T2367 SKF-86002

SKF86002

p38 MAPK; TNF Apoptosis; MAPK
SKF-86002 是一种可口服的 p38 MAPK 抑制剂,具有抗炎和抗关节炎活性,可用于缓解疼痛的研究。它能抑制脂氧合酶和环氧合酶介导的花生四烯酸代谢,还抑制脂多糖 (LPS) 刺激人单核细胞产生 IL-1 和 TNF-α,IC50为 1 μM。
T8676 FOY 251

Others; Serine/threonin kinase; SARS-CoV Cell Cycle/Checkpoint; Metabolism; Microbiology/Virology; Others
FOY 251 是一种蛋白酶抑制剂,是具有抗蛋白水解活性的 Camostate 代谢物,能抑制 SARS-CoV-2 的感染。
T6157 Devimistat

CPI-613,辛酸,CPI613,CPI 613,6,8-Bis(benzylthio)octanoic acid

Apoptosis; Dehydrogenase; Mitochondrial Metabolism Apoptosis; Metabolism
Devimistat (6,8-Bis(benzylthio)octanoic acid) 是一种线粒体代谢抑制剂,还是一种lipoic acid 拮抗剂,能阻断线粒体能量代谢,诱导多种癌细胞凋亡。
T7629 Olesoxime

NSC 21311,TRO 19622,奥利索西

Mitochondrial Metabolism Metabolism
Olesoxime (TRO 19622) 是一种靶向线粒体的神经保护性试剂,能够促进细胞存活,其 EC50=3.2±0.2 µM。
T0412 Idebenone

艾地苯醌,CV-2619

Apoptosis; Antioxidant; Mitochondrial Metabolism Apoptosis; Metabolism; oxidation-reduction
Idebenone (CV-2619) 是一种线粒体保护剂,具有神经保护功效,可用于研究阿尔茨海默病、亨廷顿舞蹈病,可透过血脑屏障,诱导细胞凋亡。
T5827 BI-6C9

Apoptosis; Others; Mitochondrial Metabolism Apoptosis; Metabolism; Others
BI-6C9 是一种高特异性的 BH3 相互作用结构域抑制剂,可阻止线粒体外膜电位和线粒体分裂,并保护细胞免受线粒体凋亡诱导因子释放和不依赖 caspase 的细胞死亡。
T12148 N-Desmethyltamoxifen hydrochloride

Estrogen Receptor/ERR; Endogenous Metabolite; PKC Chromatin/Epigenetic; Cytoskeletal Signaling; Endocrinology/Hormones; Metabolism
N-Desmethyltamoxifen hydrochloride 是 Tamoxifen 在人体内主要的三苯氧胺代谢物。它是蛋白激酶 C 抑制剂,也是人体 AML 细胞神经酰胺代谢的有效调节因子,可限制神经酰胺糖基化、水解和鞘氨醇磷酸化。
T9211 Mito-LND

Mito-Loidamine

OXPHOS; Reactive Oxygen Species; Mitochondrial Metabolism; Autophagy Apoptosis; Autophagy; Immunology/Inflammation; Metabolism; NF-κB
Mito-LND (Mito-Loidamine) 是一种有口服活性和靶向线粒体的氧化磷酸化抑制剂。它抑制线粒体生物能,刺激活性氧的形成,并诱导肺癌细胞自噬细胞死亡。
T5337 IACS-010759

IACS-10759,IACS 10759,IACS10759

Apoptosis; Others; Mitochondrial Metabolism Apoptosis; Metabolism; Others
IACS-010759 是一种口服有效的线粒体氧化磷酸化复合物 I 抑制剂。它在依赖 OXPHOS 的脑癌和急性髓性白血病模型中抑制增殖并诱导细胞凋亡,有研究复发/难治性 AML 和实体瘤潜力。
T5363 Tempo

2,2,6,6-四甲基哌啶氧化物,2,2,6,6-Tetramethylpiperidinooxy

Free radical scavengers; Reactive Oxygen Species; DNA/RNA Synthesis; Mitochondrial Metabolism Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
Tempo (2,2,6,6-Tetramethylpiperidinooxy) 可用作自由基清除剂、有机合成中的试剂和电子自旋共振光谱中的结构探针。它可在催化循环中使超氧化物歧化,也可诱导DNA 链断裂。
T24656 PQ-10

A844337,PQ 10,A-844337,A 844337

PDE Metabolism
PQ-10 (A-844337) 是磷酸二酯酶 10A 抑制剂,其IC50=4.6 nM,ED50=13 mg/kg。它能够诱导大脑葡萄糖代谢模式,这可能是潜在的转化生物标志物。它对精神分裂症等精神疾病具有研究潜力。
T8766 GOT1 inhibitor-1

GOT1 inhibitor 2c

Others Others
GOT1 inhibitor-1 (GOT1 inhibitor 2c) 是一种新型的、非共价的谷氨酸草酰乙酸转氨酶 1 (GOT1) 抑制剂(IC50:8.2 uM),是一种戊酸衍生物。 它可用于以及胰腺导管腺癌 (PDAC) 。
T3124 Carbendazim

Bavistin,Carbendazole,多菌灵,Mercarzole

Antifungal Microbiology/Virology
Carbendazim (Mercarzole) 是一种具有抗肿瘤活性的苯并咪唑衍生物,可用于癌症研究。它是一种口服广谱苯并咪唑杀菌剂,可作为真菌疾病研究的杀虫剂。
T0849 Pyrimethamine

Pirimecidan,RP 4753,Pirimetamin,乙胺嘧啶

DHFR; Antifolate; Parasite Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
Pyrimethamine (Pirimecidan) 是一种二氢叶酸还原酶的竞争性抑制剂,用作抗疟药。
T2607 MSDC 0160

CAY10415,Mitoglitazone,MSDC0160,MSDC-0160

Others; IGF-1R; Mitochondrial Metabolism Metabolism; Others; Tyrosine Kinase/Adaptors
MSDC 0160 (CAY10415) 是一种线粒体丙酮酸载体(MPC) 的调节剂,也是调节噻唑烷二酮的线粒体靶标 (mTOT) 的胰岛素增敏剂。它是一种噻唑烷二酮 (TZD),具有抗糖尿病和神经保护活性作用。它具有用于阿尔茨海默氏病的潜力。
T10814 Cinacalcet metabolite M4

3-三氟甲基苯丙胺,Rarechem AL BW 1078

Calcium Channel Membrane transporter/Ion channel; Metabolism
Cinacalcet metabolite M4 (Rarechem AL BW 1078) 是 Cinacalcet 的代谢物。Cinacalcet 是具有活性的 Ca receptor 激动剂,可用于心血管疾病。
T0239 Lonidamine

AF1890,氯尼达明,DICA,Diclondazolic Acid

Apoptosis; Hexokinase; Mitochondrial Metabolism Apoptosis; Metabolism
Lonidamine (Diclondazolic Acid) 是一种抗肿瘤药物,是己糖激酶、线粒体丙酮酸载体和质膜单羧酸转运蛋白抑制剂,同时也抑制线粒体复合物 II。
T35343 MTI-31

MTI-31,LXI-15029

mTOR PI3K/Akt/mTOR signaling
MTI-31 (LXI-15029) 是口服有效的,高度选择性的mTORC1和mTORC2抑制剂,对 mTOR 的Kd 为 0.20 nM,IC50为 39 nM。MTI-31可用于乳腺癌的研究。
T9235 GW604714X

2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-

Mitochondrial Metabolism Metabolism
GW604714X (2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-) 是一种高度特异性的线粒体丙酮酸载体抑制剂,Ki<0.1 nM。它是一种线粒体呼吸抑制剂。它也能抑制质膜单羧酸转运体的 L-乳酸转运,但浓度比 MPC 的大 4 个数量级。
T7487 Speract

精子活化肽

Others; Mitochondrial Metabolism Metabolism; Others
Speract 是调节精子活力的海胆蛋肽,也能够刺激精子线粒体代谢。
T1640 Ciprofloxacin

Ciproxan,环丙沙星,Ciprobay,Bay o 9867,Bay-09867

Topoisomerase; Antibacterial; Antibiotic DNA Damage/DNA Repair; Microbiology/Virology
Ciprofloxacin (Bay-09867) 是一种有高抗菌活性的氟喹诺酮类抗生素。

化合物

D-Histidine
Cat.No: T9372
Synonym:
Target: Mitochondrial Metabolism
THP104c
Cat.No: T9777
Synonym:
Target: Mitochondrial Metabolism
Gboxin
Cat.No: T15373
Synonym:
Target: ATPase, Mitochondrial Metabolism
Perhexiline maleate
Cat.No: T12408
Synonym:
Target: Others, Mitochondrial Metabolism
Mito-TEMPO
Cat.No: T19428
Synonym:
Target: Reactive Oxygen Species, Mitochondrial Metabolism
BAM 15
Cat.No: T14497
Synonym:
Target: OXPHOS, Mitochondrial Metabolism
ER-000444793
Cat.No: T15241
Synonym:
Target: Others, Mitochondrial Metabolism
CCI-006
Cat.No: T10706
Synonym:
Target: Mitochondrial Metabolism
Choline
Cat.No: T8734
Synonym:
Target: Others
MPP+ iodide
Cat.No: T9169
Synonym:
Target: Mitochondrial Metabolism, Autophagy
MCU-i4
Cat.No: T9031
Synonym:
Target: Others, Mitochondrial Metabolism
7ACC2
Cat.No: T1768
Synonym:
Target: Mitochondrial Metabolism, Monocarboxylate transporter
Azemiglitazone
Cat.No: T4639
Synonym: MSDC 0602
Target: Mitochondrial Metabolism, mTOR
BAY-876
Cat.No: T3713
Synonym:
Target: transporter
Adjudin
Cat.No: T2498
Synonym: AF-2364
Target: Chloride channel, Mitochondrial Metabolism
BIBB 515
Cat.No: T4039
Synonym:
Target: Others
KL1333
Cat.No: T16342
Synonym: NQO1 activator 1
Target: NADPH, Mitochondrial Metabolism
DASA-58
Cat.No: T6816
Synonym:
Target: PKM
CTPI-2
Cat.No: T8732
Synonym:
Target: Others, Mitochondrial Metabolism
FCCP
Cat.No: T6834
Synonym: Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone,Trifluoromethoxy carbonylcyanide phenylhydrazone
Target: ATPase, Mitochondrial Metabolism
Rafoxanide
Cat.No: T7093
Synonym: 碘醚柳胺,雷复尼特
Target: CDK, Parasite
SR8278
Cat.No: T7837
Synonym:
Target: Others
ESP 15228
Cat.No: T40514
Synonym: 2,2,14,14-Tetramethyl-8-oxopentadecanedioic acid
Target: Others
NL-1
Cat.No: T8308
Synonym:
Target: Mitochondrial Metabolism, Autophagy
CM10
Cat.No: T7835
Synonym: CM 10
Target: Dehydrogenase
Mitochonic acid 5
Cat.No: T8366
Synonym: MA-5
Target: Mitochondrial Metabolism
Mitochondrial fusion promoter M1
Cat.No: T9232
Synonym:
Target: Mitochondrial Metabolism
VLX600
Cat.No: T8500
Synonym:
Target: OXPHOS, Mitochondrial Metabolism, Autophagy
UK-5099
Cat.No: T4441
Synonym: UK 5099,PF-1005023,UK5099
Target: Others, Mitochondrial Metabolism
SKF-86002
Cat.No: T2367
Synonym: SKF86002
Target: p38 MAPK, TNF
FOY 251
Cat.No: T8676
Synonym:
Target: Others, Serine/threonin kinase, SARS-CoV
Devimistat
Cat.No: T6157
Synonym: CPI-613,辛酸,CPI613,CPI 613,6,8-Bis(benzylthio)octanoic acid
Target: Apoptosis, Dehydrogenase, Mitochondrial Metabolism
Olesoxime
Cat.No: T7629
Synonym: NSC 21311,TRO 19622,奥利索西
Target: Mitochondrial Metabolism
Idebenone
Cat.No: T0412
Synonym: 艾地苯醌,CV-2619
Target: Apoptosis, Antioxidant, Mitochondrial Metabolism
BI-6C9
Cat.No: T5827
Synonym:
Target: Apoptosis, Others, Mitochondrial Metabolism
N-Desmethyltamoxifen hydrochloride
Cat.No: T12148
Synonym:
Target: Estrogen Receptor/ERR, Endogenous Metabolite, PKC
Mito-LND
Cat.No: T9211
Synonym: Mito-Loidamine
Target: OXPHOS, Reactive Oxygen Species, Mitochondrial Metabolism, Autophagy
IACS-010759
Cat.No: T5337
Synonym: IACS-10759,IACS 10759,IACS10759
Target: Apoptosis, Others, Mitochondrial Metabolism
Tempo
Cat.No: T5363
Synonym: 2,2,6,6-四甲基哌啶氧化物,2,2,6,6-Tetramethylpiperidinooxy
Target: Free radical scavengers, Reactive Oxygen Species, DNA/RNA Synthesis, Mitochondrial Metabolism
PQ-10
Cat.No: T24656
Synonym: A844337,PQ 10,A-844337,A 844337
Target: PDE
GOT1 inhibitor-1
Cat.No: T8766
Synonym: GOT1 inhibitor 2c
Target: Others
Carbendazim
Cat.No: T3124
Synonym: Bavistin,Carbendazole,多菌灵,Mercarzole
Target: Antifungal
Pyrimethamine
Cat.No: T0849
Synonym: Pirimecidan,RP 4753,Pirimetamin,乙胺嘧啶
Target: DHFR, Antifolate, Parasite
MSDC 0160
Cat.No: T2607
Synonym: CAY10415,Mitoglitazone,MSDC0160,MSDC-0160
Target: Others, IGF-1R, Mitochondrial Metabolism
Cinacalcet metabolite M4
Cat.No: T10814
Synonym: 3-三氟甲基苯丙胺,Rarechem AL BW 1078
Target: Calcium Channel
Lonidamine
Cat.No: T0239
Synonym: AF1890,氯尼达明,DICA,Diclondazolic Acid
Target: Apoptosis, Hexokinase, Mitochondrial Metabolism
MTI-31
Cat.No: T35343
Synonym: MTI-31,LXI-15029
Target: mTOR
GW604714X
Cat.No: T9235
Synonym: 2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-
Target: Mitochondrial Metabolism
Speract
Cat.No: T7487
Synonym: 精子活化肽
Target: Others, Mitochondrial Metabolism
Ciprofloxacin
Cat.No: T1640
Synonym: Ciproxan,环丙沙星,Ciprobay,Bay o 9867,Bay-09867
Target: Topoisomerase, Antibacterial, Antibiotic
Cat. No. Product Name Target Signaling Pathways
T10857 Coenzyme A

Endogenous Metabolite Metabolism
Coenzyme A 是所有活细胞中必需的辅助因子,由泛酸,三磷酸腺苷和半胱氨酸合成的。Coenzyme A 与过氧化物酶 5 共价结合导致其过氧化物酶活性完全抑制,通过 DTT 还原能够逆转。Coenzyme A 及其硫酯衍生物是主要分解代谢,合成代谢途径和基因表达调控的关键参与者。
TN1586 Dihydrorotenone

Apoptosis; Mitochondrial Metabolism Apoptosis; Metabolism
Dihydrorotenone 是一种线粒体抑制剂,是天然杀虫剂。它通过触发内质网应激并激活 p38 信号通路来诱导人浆细胞凋亡,可能诱发帕金森综合症。
T8433 HQNO

Mitochondrial Metabolism Metabolism
HQNO 是一种电子传递链抑制剂,对 complex III 的Kd 值为 64 nM,由P. aeruginosa 产生的。它是许多物种的线粒体NDH-2的有效抑制剂。
TN6772 Malabaricone C

Others Others
Malabaricone C 是天然的鞘磷脂合成酶抑制剂,对 SMS 1 和 SMS 2 的IC50分别为 3 和 1.5 μM。
T14140 Agaric acid

落叶松蕈酸,Agaricinic Acid

Mitochondrial Metabolism; AChR Metabolism; Neuroscience
Agaric acid (Agaricinic Acid) 来一种自真菌部落的Polyporus officinalis 和Polyporus igniarius。它可促进积累的 Ca2+流出,跨膜电位的破坏和线粒体肿胀。它通过其与腺嘌呤核苷酸转位酶的相互作用诱导线粒体通透性转变。它用于调节脂类代谢。
T8091 trans-4-Hydroxycyclohexanecarboxylic Acid

Others Others
trans-4-Hydroxycyclohexanecarboxylic acid 是一种合成环己烷酸的底物 (substrate)。它是肠道细菌代谢的副产物 (by-product),能够通过尿路排泄。
T7922 Kresoxim-Methyl

Others; Mitochondrial Metabolism; Antifungal Metabolism; Microbiology/Virology; Others
Kresoxim-methyl 是一种嗜球果伞素类杀菌剂,可抑制复合体 III 的呼吸,抑制苹果园分离株 V. inaequalis 的分生孢子萌发。
T0938 Thiabendazole

2-(4-Thiazolyl)benzimidazole,噻菌灵

Microtubule Associated; Mitochondrial Metabolism; Parasite Cytoskeletal Signaling; Metabolism; Microbiology/Virology
Thiabendazole (2-(4-Thiazolyl)benzimidazole) 是具有驱虫特性的苯并咪唑衍生物。
T4766 3-Methylglutaric acid

Endogenous Metabolite Metabolism
3-Methylglutaric acid 是亮氨酸代谢物,是一种与两种亮氨酸途径 HMGCL、AUH 酶缺陷显著相关的 C6 二元羧酸有机酸。
T3804 Neomangiferin

Mangiferin 7-glucoside,新芒果苷

Phosphatase Metabolism
Neomangiferin (Mangiferin 7-glucoside) 是一种天然的 C-glucosyl xanthone,分离自干燥的Anemarrhena asphodeloides 的根茎中。它能够减轻大鼠高脂饮食诱导的非酒精性脂肪性肝病 (NAFLD)。
T2970 Rotenone

Rotenon,鱼藤酮,Paraderil,Barbasco,Rotocide,Dactinol

Apoptosis; Dehydrogenase; Mitochondrial Metabolism; p53; Autophagy Apoptosis; Autophagy; Metabolism
Rotenone (Rotocide) 属于天然产物,是一种植物杀虫剂。Rotenone 是一种线粒体电子传递复合物 I 抑制剂,可以促进线粒体产生活性氧,并诱导细胞凋亡。
T13795 Nicotinamide riboside

Sirtuin Chromatin/Epigenetic; DNA Damage/DNA Repair
Nicotinamide riboside 是维生素 B3 的来源,可以增强氧化代谢并防止高脂肪饮食诱导的代谢异常。它是具有口服活性的 NAD+的前体,增加 NAD+水平并激活SIRT1和SIRT3,可用于研究阿尔茨海默氏病的认知退化。
TN1362 Afzelin

阿福豆苷,Kaempferol-3-O-rhamnoside

PTEN; p38 MAPK; TNF; Mitochondrial Metabolism; Antibacterial; Prostaglandin Receptor; Autophagy Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; MAPK; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling
Afzelin (Kaempferol-3-O-rhamnoside) 具有多种细胞活性,例如 DNA 保护、抗菌、抗氧化和抗炎以及 UV 吸收活性,并且可以通过 UV 吸收和细胞活性的组合保护人体皮肤免受 UVB 引起的损伤。 Afzelin 减轻线粒体损伤,增强线粒体生物合成并降低线粒体自噬相关蛋白、parkin 和 putative kinase 1 的水平。
T0846 L-Carnitine

L(-)-Carnitine,Levocarnitine,左旋肉碱

Endogenous Metabolite; Fatty Acid Synthase Metabolism
L-Carnitine (L(-)-Carnitine) 是一种人内源性分子,在人体内以蛋氨酸和赖氨酸为底物进行生物合成,并参与脂肪酸代谢。L-Carnitine 将长链脂肪酰辅酶A 转运到线粒体。L-Carnitine 能够改善许多先天性代谢错误的代谢失衡。
T5645 Nerol

Cis-Geraniol,橙花醇,Neryl alcohol

Apoptosis; Reactive Oxygen Species; Mitochondrial Metabolism; Endogenous Metabolite; Antifungal Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
Nerol (Neryl alcohol) 是橙花油的一种单萜, 它通过增强 Ca2+和ROS 来触发线粒体功能障碍并诱导凋亡,具有抗真菌活性。它可减轻哺乳动物心脏中哇巴因引发的心律失常的严重程度。
T0437 Inosine

INO 495,NSC 20262,肌苷

ROS; Endogenous Metabolite; Adenosine Receptor GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
Inosine (NSC-20262) 是由腺苷分解代谢产生的一种内源性嘌呤核苷,是腺苷受体A1R 和A2AR 的激动剂,具有抗炎免疫调节,抗伤害和神经保护作用。
T2899 Liquiritin

Liquiritigenin-4'-O-glucoside,Liquiritoside,甘草苷

Reactive Oxygen Species Immunology/Inflammation; Metabolism; NF-κB
Liquiritin (Liquiritigenin-4'-O-glucoside) 是一种从甘草中分离出的类黄酮,是一种竞争性的 AKR1C1 抑制剂,对 AKR1C1,AKR1C2 和 AKR1C3 的 IC50分别为 0.62 μM,0.61 μM 和 3.72 μM,在体内有效抑制 AKR1C1 介导的孕酮代谢。它是一种抗氧化剂,具有神经保护、抗癌、抗炎的活性。
T20089 ATP

Atipi,ATP disodium salt hydrate,Triphosphoric acid adenosine ester,Ara-ATP,Triphosphaden,Adenosine triphosphate;Ara-ATP,Adenosine triphosphate

Endogenous Metabolite Metabolism
ATP (Adenosine triphosphate) 可为细胞提供能量,参与整体能量平衡,维持细胞内稳态。ATP 可以通过与特异性嘌呤能受体的相互作用充当细胞外信号分子,以介导神经传递、炎症、细胞凋亡和骨重塑等多种过程。
T3898 Schaftoside

夏佛塔苷,APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE,Shaftoside

Dynamin; Antioxidant; TLR; MyD88; Mitochondrial Metabolism; Autophagy Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; oxidation-reduction
Schaftoside (APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE) 是在多种中草药中发现的一种黄酮类天然产物。它抑制 TLR4 和 Myd88 表达,还降低 Drp1 表达和磷酸化,并减少线粒体分裂,具有抗氧化和抗癌活性。
T9352 hydrocotarnine

Others Others
hydrocotarnine 是 Cbl 的抑制剂。
T2A2532 L-Histidine

Glyoxaline-5-alanine,L-(-)-Histidine,L-组氨酸,histidine,组氨酸,L-Hisidine

Mitochondrial Metabolism; Endogenous Metabolite Metabolism
L-Histidine (L-(-)-Histidine) 是人类生长和组织修复所需的一种半必需氨基酸(儿童应从食物中获得)。 L-Histidine 是线粒体谷氨酰胺转运的抑制剂。
TN1353 N-Benzyllinoleamide

(9Z,12Z)-N-Benzyloctadeca-9,12-dienamide,N-苄基-(9Z,12Z)-十八碳二烯酰胺

Others Others
N-Benzyllinoleamide ((9Z,12Z)-N-Benzyloctadeca-9,12-dienamide) 是一种分离自 Lepidium meyeniiWalp,能够抗运动性疲劳的药物。
T2901 Daidzin

NPI-031D,大豆苷,Daidzein 7-O-glucoside,Daidzoside,黄豆苷,Daidzein 7-glucoside

Dehydrogenase; Reverse Transcriptase; Mitochondrial Metabolism Metabolism; Microbiology/Virology
Daidzin (Daidzoside) 是从大豆中分离出来的一种异黄酮,具有抗氧化、抗癌和抗动脉粥样硬化的活性。
T6220 Nicotinamide riboside chloride

烟酰胺核糖氯酸盐,烟酰胺核苷

Sirtuin; Endogenous Metabolite Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
Nicotinamide riboside Chloride 是维生素 B3 的来源,可以增强氧化代谢并防止高脂肪饮食诱导的代谢异常。它是具有口服活性的 NAD+的前体,增加 NAD+水平并激活SIRT1和SIRT3,可用于研究阿尔茨海默氏病的认知退化。
T0700 Ursodeoxycholic acid

熊去氧胆酸,UDCA,Ursodiol

Potassium Channel; Endogenous Metabolite Membrane transporter/Ion channel; Metabolism
Ursodeoxycholic acid (UDCA)是一种有效的肝脏特异性脂肪酸转运蛋白 5 (FATP5) 抑制剂,通过 FATP5 依赖性方式抑制原代肝细胞摄取长链脂肪酸。Ursodeoxycholic acid 能够抑制胆固醇的吸收,用于溶解胆结石,并具有研究与肥胖相关的脂肪肝疾病的潜力。
T2812 ATP disodium salt hydrate

ATP disodium,ATP disodium salt,Adenosine disodium triphosphate,三磷酸腺苷二钠盐

Others; Endogenous Metabolite Metabolism; Others
ATP disodium salt hydrate (Adenosine disodium triphosphate) 是体内能量储存和代谢的重要物质,为代谢提供能量,同时在细胞中作为辅酶发挥作用。同时,它是也是免疫和炎症中重要的内源性信号分子。
T1153 Trimethoprim

NIH 204,BW 56-72,甲氧苄啶,NSC-106568

DHFR; DNA/RNA Synthesis; Antifolate; Antibacterial; Antibiotic Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
Trimethoprim (NSC-106568) 是抑菌抗生素,也是具有口服活性的二氢叶酸还原酶抑制剂。它对多种革兰氏阳性和革兰氏阴性需氧细菌具有活性,可用于尿路感染,肺孢子菌肺炎和志贺氏菌病的研究。
T9368 3,4-(Methylenedioxy)cinnamic acid

3-(Benzo[d][1,3]dioxol-5-yl)acrylic acid,3,4-(亚甲二氧)肉桂酸

Others Others
3,4-(Methylenedioxy)cinnamic acid (3-(Benzo[d][1,3]dioxol-5-yl)acrylic acid) 是一种植物衍生化合物,首先从芦笋的根中提取,并进一步表征为一种化感化学物质。
T22235 Lipoic acid

R-(+)-硫辛酸,硫辛酸,R-(+)-Thioctic acid,(R)-(+)-1,2-Dithiolane-3-pentanoic acid,(R)-(+)-α-Lipoic acid

Reactive Oxygen Species; Mitochondrial Metabolism; Endogenous Metabolite Immunology/Inflammation; Metabolism; NF-κB
Lipoic acid (R-(+)-Thioctic acid) ((R)-(+)-α-Lipoic acid) 是一种抗氧化剂,是线粒体酶复合物的重要辅助因子。与外消旋 Lipoic acid 相比,Lipoic acid ((R)-(+)-α-Lipoic acid)更有效。
T5564 Tricarballylic acid

β-Carboxyglutaric acid,1,2,3-Propanetricarboxylic acid,三碳烯丙酸,Carballylic acid,Propane-1,2,3-tricarboxylic acid,丙三酸

aconitase; Mitochondrial Metabolism Metabolism
Tricarballylic acid (Carballylic acid) 是三碳烯丙酸酯的共轭酸,是一种乌头酸水合酶的竞争性抑制剂,其 Ki= 0.52 mM。
T1352 ATP disodium salt

Adenosine 5'-triphosphate disodium salt,三磷酸腺苷二钠,ATP,ATP disodium,腺苷-5'-三磷酸二钠盐,Adetide,Adenosine-Triphosphate,Disodium adenosine triphosphate

P2X Receptor; Endogenous Metabolite Membrane transporter/Ion channel; Metabolism; Neuroscience
ATP disodium salt (Adenosine-Triphosphate) 是体内能量储存的重要物质,为代谢提供能量,同时在细胞中作为辅酶发挥作用。Adenosine 5'-triphosphate disodium salt 也是免疫和炎症中重要的内源性信号分子。
T0200 α-Lipoic Acid

Thioctic acid,DL-α-Lipoic acid,(±)-α-Lipoic acid,α-硫辛酸,硫辛酸

Apoptosis; NF-κB; HIV Protease; Mitochondrial Metabolism; Endogenous Metabolite Apoptosis; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
α-Lipoic Acid (DL-α-Lipoic acid) 是线粒体酶复合物的重要辅助因子,是一种抗氧化剂,可抑制NF-κB 依赖性的HIV-1LTR 活化。它还可诱导内质网应激介导的肝癌细胞凋亡。
T29078 Ursodeoxycholic acid sodium

UDCA Na,UDCA sodium,Sodium Ursodeoxycholate,熊去氧胆酸钠盐,Ursodiol sodium,Ursodeoxycholic Acid (sodium salt),Ursodeoxycholate sodium

FXR; Endogenous Metabolite; GPCR19 GPCR/G Protein; Metabolism
Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) 是一种天然存在的次级胆汁酸,具有抗炎和细胞保护活性。Ursodeoxycholic acid sodium 作为信号分子,通过与胆汁酸激活受体相互作用发挥其作用,包括 G 蛋白偶联胆汁酸受体 5 (TGR5) 和法尼醇 X 受体 (FXR)。
T5213 Acetyl phosphate(lithium potassium)

乙酰磷酸锂钾盐,Lithium potassium acetyl phosphate,Acetylphosphoric acid

Others; Endogenous Metabolite Metabolism; Others
Acetyl phosphate lithium potassium (Lithium potassium acetyl phosphate) 是内源性代谢产物的一种。
T4942 Galactose 1-phosphate Potassium salt

D-半乳糖 1-磷酸二钾盐五水合物,α-D-Galactose-1-phosphate Dipotassium Pentahydrate

Others; Endogenous Metabolite Metabolism; Others
Galactose 1-phosphate Potassium salt (α-D-Galactose-1-phosphate Dipotassium Pentahydrate) 是一种半乳糖代谢中的中间体和核苷酸糖。
TN6752 Dimethyl sulfone

Endogenous Metabolite Metabolism
Dimethyl sulfone 是内源性代谢产物的一种。
T1040 Vitamin B12

Cyanocobalamin,Cobalamin,维生素B12

Endogenous Metabolite Metabolism
Vitamin B12 (Cobalamin) 是一种维生素,在维持血流形成和脑、神经系统正常功能等方面发挥关键作用。
TN7132 4,12-Dimethoxy-6-(7,8-dihydroxy-7,8-dihydrostyryl)-2-pyrone

Others Others
4,12-Dimethoxy-6-(7,8-dihydroxy-7,8-dihydrostyryl)-2-pyrone 是一种来自 Piper methysticum 的主要苯乙烯内酯 yangonin 的微生物代谢产物。
T4829 3-Hydroxyphenylacetic acid

Others; Endogenous Metabolite Metabolism; Others
3-Hydroxyphenylacetic acid 是内源性代谢产物的一种。
T5251 Phenylpyruvic acid

2-Oxo-3-phenylpropanoic acid,3-Phenylpyruvic acid,苯丙酮酸

Others; Endogenous Metabolite Metabolism; Others
Phenylpyruvic acid (3-Phenylpyruvic acid) 可以通过乳酸脱氢酶合成3-苯基乳酸 (PLA)。
T5078 Orotic acid monohydrate

2,4-dioxo-1H-pyrimidine-6-carboxylic acid hydrate,Orotic Acid Monohydrate,2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid hydrate,乳清酸一水合物

Others; Endogenous Metabolite Metabolism; Others
Orotic acid monohydrate (2,4-dioxo-1H-pyrimidine-6-carboxylic acid hydrate) 是内源性代谢产物的一种。
T14840 Butyrylcarnitine

Endogenous Metabolite Metabolism
Butyrylcarnitine 是血浆中的代谢物,是疾病引起异常代谢的指标,可用于诊断心力衰竭和胰腺囊肿。
T19115 3,4-Dimethylbenzoic acid

1-Carboxy-3,4-dimethylbenzene,3,4-二甲基苯甲酸

Others Others
3,4-Dimethylbenzoic acid (1-Carboxy-3,4-dimethylbenzene) 是 Rhodococcus rhodochrous N75 代谢苯甲酸二甲酯的产物。
T10147 4-Hydroxymephenytoin

(+/-)-4'-Hydroxymephenytoin

Others; Drug Metabolite Metabolism; Others
4-Hydroxymephenytoin ((+/-)-4'-Hydroxymephenytoin) 是抗癫痫药 mephenytoin 的代谢产物。Mephenytoin 是 CYP2C19的配体。
T21367 Tetrahydrofolic acid

5,6,7,8-tetrahydrofolic acid,folate-H4,Tetrahydropteroylglutamic acid,th-folate

Endogenous Metabolite Metabolism
Tetrahydrofolic acid (5,6,7,8-tetrahydrofolic acid) 是一种维生素 B9 衍生物,是生物体常见的一碳供体,参与生物体生长代谢。
T0800 Danthron

Dantron,1,8-Dihydroxyanthraquinone,1,8-二羟基蒽醌,丹蒽醌,Chrysazin,Antrapurol

Virus Protease; Antibacterial; AMPK; Autophagy Autophagy; Chromatin/Epigenetic; Microbiology/Virology; PI3K/Akt/mTOR signaling
Danthron (Antrapurol) 是一种从中药 rhubarb 中提取的天然产物,可通过激活 AMPK 来调节葡萄糖和脂质代谢。
T0894 Thiamine hydrochloride

盐酸硫胺素,Vitamin B1,Vitamin B1 hydrochloride,Thiamine HCl,盐酸硫胺(维生素B1),Thiamine chloride hydrochloride

Apoptosis; HBV; Endogenous Metabolite Apoptosis; Metabolism; Microbiology/Virology
Thiamine hydrochloride (Vitamin B1) 是一种必需的微量营养素,是许多中枢代谢酶的辅因子。
T8714 1-Stearoyl-sn-glycero-3-phosphocholine

1-硬脂酰-SN-甘油-3-磷酰胆碱,1-stearoyl-lysophosphatidylcholine,L-ALPHA-LYSOPHOSPHATIDYLCHOLINE, STEAROY

Others Others
1-Stearoyl-sn-glycero-3-phosphocholine (L-ALPHA-LYSOPHOSPHATIDYLCHOLINE, STEAROY) 是一种用于脂质代谢研究的化学物质。
T64980 ATP disodium trihydrate

Adenosine-5'-triphosphate disodium trihydrate

Endogenous Metabolite Metabolism
ATP disodium trihydrate (Adenosine-5'-triphosphate disodium trihydrate) 是体内能量储存和代谢的重要物质,是免疫和炎症中重要的内源性信号分子,可为机体代谢提供能量,同时在细胞中作为辅酶发挥作用。
T4461 3,5-Diiodo-L-thyronine

3,5-二碘-L-甲状腺素,Diiodothyronine

Thyroid hormone receptor(THR); Endogenous Metabolite Endocrinology/Hormones; Metabolism
3,5-Diiodo-L-thyronine (Diiodothyronine) 是内源性代谢产物的一种。
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天然产物

Coenzyme A
Cat.No: T10857
Synonym:
Target: Endogenous Metabolite
Dihydrorotenone
Cat.No: TN1586
Synonym:
Target: Apoptosis, Mitochondrial Metabolism
HQNO
Cat.No: T8433
Synonym:
Target: Mitochondrial Metabolism
Malabaricone C
Cat.No: TN6772
Synonym:
Target: Others
Agaric acid
Cat.No: T14140
Synonym: 落叶松蕈酸,Agaricinic Acid
Target: Mitochondrial Metabolism, AChR
trans-4-Hydroxycyclohexanecarboxylic Acid
Cat.No: T8091
Synonym:
Target: Others
Kresoxim-Methyl
Cat.No: T7922
Synonym:
Target: Others, Mitochondrial Metabolism, Antifungal
Thiabendazole
Cat.No: T0938
Synonym: 2-(4-Thiazolyl)benzimidazole,噻菌灵
Target: Microtubule Associated, Mitochondrial Metabolism, Parasite
3-Methylglutaric acid
Cat.No: T4766
Synonym:
Target: Endogenous Metabolite
Neomangiferin
Cat.No: T3804
Synonym: Mangiferin 7-glucoside,新芒果苷
Target: Phosphatase
Rotenone
Cat.No: T2970
Synonym: Rotenon,鱼藤酮,Paraderil,Barbasco,Rotocide,Dactinol
Target: Apoptosis, Dehydrogenase, Mitochondrial Metabolism, p53, Autophagy
Nicotinamide riboside
Cat.No: T13795
Synonym:
Target: Sirtuin
Afzelin
Cat.No: TN1362
Synonym: 阿福豆苷,Kaempferol-3-O-rhamnoside
Target: PTEN, p38 MAPK, TNF, Mitochondrial Metabolism, Antibacterial, Prostaglandin Receptor, Autophagy
L-Carnitine
Cat.No: T0846
Synonym: L(-)-Carnitine,Levocarnitine,左旋肉碱
Target: Endogenous Metabolite, Fatty Acid Synthase
Nerol
Cat.No: T5645
Synonym: Cis-Geraniol,橙花醇,Neryl alcohol
Target: Apoptosis, Reactive Oxygen Species, Mitochondrial Metabolism, Endogenous Metabolite, Antifungal
Inosine
Cat.No: T0437
Synonym: INO 495,NSC 20262,肌苷
Target: ROS, Endogenous Metabolite, Adenosine Receptor
Liquiritin
Cat.No: T2899
Synonym: Liquiritigenin-4'-O-glucoside,Liquiritoside,甘草苷
Target: Reactive Oxygen Species
ATP
Cat.No: T20089
Synonym: Atipi,ATP disodium salt hydrate,Triphosphoric acid adenosine ester,Ara-ATP,Triphosphaden,Adenosine triphosphate;Ara-ATP,Adenosine triphosphate
Target: Endogenous Metabolite
Schaftoside
Cat.No: T3898
Synonym: 夏佛塔苷,APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE,Shaftoside
Target: Dynamin, Antioxidant, TLR, MyD88, Mitochondrial Metabolism, Autophagy
hydrocotarnine
Cat.No: T9352
Synonym:
Target: Others
L-Histidine
Cat.No: T2A2532
Synonym: Glyoxaline-5-alanine,L-(-)-Histidine,L-组氨酸,histidine,组氨酸,L-Hisidine
Target: Mitochondrial Metabolism, Endogenous Metabolite
N-Benzyllinoleamide
Cat.No: TN1353
Synonym: (9Z,12Z)-N-Benzyloctadeca-9,12-dienamide,N-苄基-(9Z,12Z)-十八碳二烯酰胺
Target: Others
Daidzin
Cat.No: T2901
Synonym: NPI-031D,大豆苷,Daidzein 7-O-glucoside,Daidzoside,黄豆苷,Daidzein 7-glucoside
Target: Dehydrogenase, Reverse Transcriptase, Mitochondrial Metabolism
Nicotinamide riboside chloride
Cat.No: T6220
Synonym: 烟酰胺核糖氯酸盐,烟酰胺核苷
Target: Sirtuin, Endogenous Metabolite
Ursodeoxycholic acid
Cat.No: T0700
Synonym: 熊去氧胆酸,UDCA,Ursodiol
Target: Potassium Channel, Endogenous Metabolite
ATP disodium salt hydrate
Cat.No: T2812
Synonym: ATP disodium,ATP disodium salt,Adenosine disodium triphosphate,三磷酸腺苷二钠盐
Target: Others, Endogenous Metabolite
Trimethoprim
Cat.No: T1153
Synonym: NIH 204,BW 56-72,甲氧苄啶,NSC-106568
Target: DHFR, DNA/RNA Synthesis, Antifolate, Antibacterial, Antibiotic
3,4-(Methylenedioxy)cinnamic acid
Cat.No: T9368
Synonym: 3-(Benzo[d][1,3]dioxol-5-yl)acrylic acid,3,4-(亚甲二氧)肉桂酸
Target: Others
Lipoic acid
Cat.No: T22235
Synonym: R-(+)-硫辛酸,硫辛酸,R-(+)-Thioctic acid,(R)-(+)-1,2-Dithiolane-3-pentanoic acid,(R)-(+)-α-Lipoic acid
Target: Reactive Oxygen Species, Mitochondrial Metabolism, Endogenous Metabolite
Tricarballylic acid
Cat.No: T5564
Synonym: β-Carboxyglutaric acid,1,2,3-Propanetricarboxylic acid,三碳烯丙酸,Carballylic acid,Propane-1,2,3-tricarboxylic acid,丙三酸
Target: aconitase, Mitochondrial Metabolism
ATP disodium salt
Cat.No: T1352
Synonym: Adenosine 5'-triphosphate disodium salt,三磷酸腺苷二钠,ATP,ATP disodium,腺苷-5'-三磷酸二钠盐,Adetide,Adenosine-Triphosphate,Disodium adenosine triphosphate
Target: P2X Receptor, Endogenous Metabolite
α-Lipoic Acid
Cat.No: T0200
Synonym: Thioctic acid,DL-α-Lipoic acid,(±)-α-Lipoic acid,α-硫辛酸,硫辛酸
Target: Apoptosis, NF-κB, HIV Protease, Mitochondrial Metabolism, Endogenous Metabolite
Ursodeoxycholic acid sodium
Cat.No: T29078
Synonym: UDCA Na,UDCA sodium,Sodium Ursodeoxycholate,熊去氧胆酸钠盐,Ursodiol sodium,Ursodeoxycholic Acid (sodium salt),Ursodeoxycholate sodium
Target: FXR, Endogenous Metabolite, GPCR19
Acetyl phosphate(lithium potassium)
Cat.No: T5213
Synonym: 乙酰磷酸锂钾盐,Lithium potassium acetyl phosphate,Acetylphosphoric acid
Target: Others, Endogenous Metabolite
Galactose 1-phosphate Potassium salt
Cat.No: T4942
Synonym: D-半乳糖 1-磷酸二钾盐五水合物,α-D-Galactose-1-phosphate Dipotassium Pentahydrate
Target: Others, Endogenous Metabolite
Dimethyl sulfone
Cat.No: TN6752
Synonym:
Target: Endogenous Metabolite
Vitamin B12
Cat.No: T1040
Synonym: Cyanocobalamin,Cobalamin,维生素B12
Target: Endogenous Metabolite
4,12-Dimethoxy-6-(7,8-dihydroxy-7,8-dihydrostyryl)-2-pyrone
Cat.No: TN7132
Synonym:
Target: Others
3-Hydroxyphenylacetic acid
Cat.No: T4829
Synonym:
Target: Others, Endogenous Metabolite
Phenylpyruvic acid
Cat.No: T5251
Synonym: 2-Oxo-3-phenylpropanoic acid,3-Phenylpyruvic acid,苯丙酮酸
Target: Others, Endogenous Metabolite
Orotic acid monohydrate
Cat.No: T5078
Synonym: 2,4-dioxo-1H-pyrimidine-6-carboxylic acid hydrate,Orotic Acid Monohydrate,2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid hydrate,乳清酸一水合物
Target: Others, Endogenous Metabolite
Butyrylcarnitine
Cat.No: T14840
Synonym:
Target: Endogenous Metabolite
3,4-Dimethylbenzoic acid
Cat.No: T19115
Synonym: 1-Carboxy-3,4-dimethylbenzene,3,4-二甲基苯甲酸
Target: Others
4-Hydroxymephenytoin
Cat.No: T10147
Synonym: (+/-)-4'-Hydroxymephenytoin
Target: Others, Drug Metabolite
Tetrahydrofolic acid
Cat.No: T21367
Synonym: 5,6,7,8-tetrahydrofolic acid,folate-H4,Tetrahydropteroylglutamic acid,th-folate
Target: Endogenous Metabolite
Danthron
Cat.No: T0800
Synonym: Dantron,1,8-Dihydroxyanthraquinone,1,8-二羟基蒽醌,丹蒽醌,Chrysazin,Antrapurol
Target: Virus Protease, Antibacterial, AMPK, Autophagy
Thiamine hydrochloride
Cat.No: T0894
Synonym: 盐酸硫胺素,Vitamin B1,Vitamin B1 hydrochloride,Thiamine HCl,盐酸硫胺(维生素B1),Thiamine chloride hydrochloride
Target: Apoptosis, HBV, Endogenous Metabolite
1-Stearoyl-sn-glycero-3-phosphocholine
Cat.No: T8714
Synonym: 1-硬脂酰-SN-甘油-3-磷酰胆碱,1-stearoyl-lysophosphatidylcholine,L-ALPHA-LYSOPHOSPHATIDYLCHOLINE, STEAROY
Target: Others
ATP disodium trihydrate
Cat.No: T64980
Synonym: Adenosine-5'-triphosphate disodium trihydrate
Target: Endogenous Metabolite
3,5-Diiodo-L-thyronine
Cat.No: T4461
Synonym: 3,5-二碘-L-甲状腺素,Diiodothyronine
Target: Thyroid hormone receptor(THR), Endogenous Metabolite
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Cat. No. Product Name Species Expression System
TMPY-00395 Insulin Protein, Human, Recombinant

IDDM1,MODY10,ILPR,IDDM2,IRDN,IDDM,insulin,INS

Human P. pastoris (Yeast)
INS (Insulin) is a Protein Coding gene. This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. The binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Diseases associated with ...
TMPY-00322 DEC-205 Protein, Human, Recombinant (His)

GP200-MR6,CD205,CLEC13B,lymphocyte antigen 75,LY-75,DEC-205

Human HEK293 Cells
LY75 (Lymphocyte Antigen 75) is a Protein Coding gene. It is broadly expressed in the lymph node, appendix, and other tissues. LY75 knockdown in SKOV3 cells resulted in predominant upregulation of functional pathways implicated in cell proliferation and metabolism, while pathways associated with cell signaling and adhesion, complement activation, and immune response were mostly suppressed. Moreover, LY75 suppression had an opposite effect on EOC cell lines with the epithelial phenotype (A2780s a...
TMPY-02707 PAH Protein, Human, Recombinant (415 Asn/Asp, His)

phenylalanine hydroxylase,PH,PKU1,PKU

Human Baculovirus Insect Cells
PAH (phenylalanine hydroxylase), also known as PH, belongs to the biopterin-dependent aromatic amino acid hydroxylase family. It contains 1 ACT domain, N-terminal region of PAH is thought to contain allosteric binding sites for phenylalanine and to constitute an "inhibitory" domain that regulates the activity of a catalytic domain in the C-terminal portion of the molecule. In humans, PAH is expressed both in the liver and the kidney, and there is some indication that it may be differentially reg...
TMPY-03962 AFM Protein, Human, Recombinant (His)

afamin,ALBA,ALB2,ALF

Human HEK293 Cells
Afamin is an 87 kDa glycoprotein with five predicted N-glycosylation sites. Afamin's glycan abundance contributes to conformational and chemical inhomogeneity presenting great challenges for molecular structure determination. Afamin, a human plasma glycoprotein and putative transporter of hydrophobic molecules, has been shown to act as extracellular chaperone for poorly soluble, acylated Wnt proteins, forming a stable, soluble complex with functioning Wnt proteins. The 2.1-Å crystal structure of...
TMPY-02062 SULT1A1 Protein, Human, Recombinant (His)

HAST1/HAST2,PST,P-PST,ST1A1,STP,sulfotransferase family, cyt...

Human E. coli
Sulfate conjugation catalyzed by cytosolic sulfotransferase (SULT) enzymes. The SULTs are Phase II drug-metabolizing enzymes that catalyze the addition of a sulfuryl moiety to both endogenous compounds, including steroids and neurotransmitters, and certain xenobiotics, including N-hydroxy-2-acetylaminoflourine and phenolic compounds, like alpha-naphthol. SULTs may be involved in the individual genetic disposition, species differences, and organotropisms for toxicological effects of chemicals. Pa...
TMPY-04552 AKT1 Protein, Human, Recombinant (His)

RAC-ALPHA,v-akt murine thymoma viral oncogene homolog 1,RAC,...

Human Baculovirus Insect Cells
v-akt murine thymoma viral oncogene homolog 1 (AKT1), or protein kinase B-alpha (PKB-ALPHA) is a serine-threonine protein kinase, belonging to the Protein Kinase Superfamily. AKT1 is a major mediator of the responses to insulin, insulin-like growth factor 1 (IGF1), and glucose. AKT1 also plays a key role in the regulation of both muscle cell hypertrophy and atrophy. AKT1 activity is required for physiologic cardiac growth in response to IGF1 stimulation or exercise training. In contrast, AKT1 ac...
TMPY-02219 Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS1 Protein (His)

NS1 Protein

H1N1 E. coli
The NS1 Influenza protein is created by the internal protein-encoding, linear negative-sense, single-stranded RNA, NS gene segment and which also codes for the nuclear export protein or NEP, formerly referred to as the NS2 protein, which mediates the export of vRNPs. The non-structural (NS1) protein is found in Influenzavirus A, Influenzavirus B, and Influenzavirus C. The non-structural (NS1) protein of the highly pathogenic avian H5N1 viruses circulating in poultry and waterfowl in Southeast As...
TMPY-00481 AKR1C4 Protein, Human, Recombinant (His)

aldo-keto reductase family 1, member C4,3-alpha-HSD,DD4,CHDR...

Human E. coli
Aldo-keto reductases comprise of AKR1C1-AKR1C4, four enzymes that catalyze NADPH dependent reductions and have been implicated in biosynthesis, intermediary metabolism, and detoxification. there is a strong correlation between the expression levels of these family members and the malignant transformation as well as the resistance to cancer therapy. Type I human hepatic 3alpha-hydroxysteroid dehydrogenase (AKR1C4) plays a significant role in bile acid biosynthesis, steroid hormone metabolism, an...
TMPJ-01072 GALK2 Protein, Human, Recombinant (His)

GalNAc kinase,N-acetylgalactosamine kinase,Galactokinase 2,G...

Human HEK293 Cells
GALK2 acts as a galactokinase when galactose is present at high concentrations. GALK2 may be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates. GALK2 has been reported to participate in pathways , such as Amino sugar and nucleotide sugar metabolism, Galactose metabolism and Metabolic pathways.
TMPK-00516 BST1 Protein, Cynomolgus, Recombinant (His)

Bp-3,CD157,Bst1,BST-1,Ly65,Bp3,Antigen BP3

Cynomolgus HEK293 Cells
BST1 overexpression conferred resistance to sphingosine in yeast. BST1 deletion produced sensitivity to exogenous D-erythro-sphingosine and phytosphingosine and intracellular accumulation of sphingosine 1-phosphate upon exposure to exogenous sphingosine. sphingoid base metabolism is similar in all eukaryotes and suggests that yeast genetics may be useful in the isolation and identification of other genes involved in sphingolipid signaling and metabolism.
TMPH-01563 IAPP Protein, Human, Recombinant (His)

IAPP,Diabetes-associated peptide,Insulinoma amyloid peptide,...

Human P. pastoris (Yeast)
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
TMPJ-00158 Apolipoprotein A-I/APOA1 Protein, Human, Recombinant

Apolipoprotein A-I,APOA1,Apo-AI,ApoA-I

Human E. coli
Apolipoprotein A1 (APOA1) is a secreted protein which belongs to the Apolipoprotein A1/A4/E family. APOA1 is the major protein component of high density lipoprotein (HDL) in plasma. APOA1 plays a critical role in various biological processes, such as Cholesterol metabolism, Lipid metabolism and transport, Steroid metabolism. APOA1 promotes cholesterol efflux from tissues to the liver and thus helps to clear cholesterol from arteries. Defects in this gene resulted in HDL deficiencies, including T...
TMPH-01670 Metallothionein-4/MT4 Protein, Human, Recombinant (His & SUMO)

MT4,Metallothionein-4,Metallothionein-IV

Human E. coli
Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia.
TMPH-02561 CES1C Protein, Mouse, Recombinant (GST)

Liver carboxylesterase N,Es1,Lung surfactant convertase,Carb...

Mouse E. coli
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Involved in the extracellular metabolism of lung surfactant.
TMPH-00608 Dihydrofolate reductase Protein, E. coli, Recombinant (His)

Dihydrofolate reductase,folA,tmrA

E. coli E. coli
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
TMPH-02562 CES1C Protein, Mouse, Recombinant (His & Myc)

Ces1c,Liver carboxylesterase N,Es1,Lung surfactant convertas...

Mouse HEK293 Cells
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Involved in the extracellular metabolism of lung surfactant.
TMPK-01087 Apolipoprotein A-V/APOA5 Protein, Mouse, Recombinant (His)

ApoA-V,Apolipoprotein A-V,Rap3,Apoa5,Apo-AV,Apolipoprotein A...

Mouse E. coli
APOA5 is probably the gene with the strongest effect on triglyceride (TG) metabolism. APOA5 is almost exclusively expressed in the liver, and its product apoAV has a very low circulating concentration. New physiological roles of apoAV have been recently elucidated, such as control of chylomicron production in the intestine and TG accumulation in adipose tissue.The key role of APOA5 in TG metabolism has been largely shown through genetic studies in association with either severe or moderate hyper...
TMPY-02622 Aldolase B Protein, Human, Recombinant (GST)

aldolase B, fructose-bisphosphate,ALDO2,ALDB

Human E. coli
The aldolase family members involved in metabolism and glycolysis are present in three isoforms: ALDOA, ALDOB, and ALDOC. Aldolases are differentially expressed in human tissues, and aberrant expression has been observed in several human diseases and cancer types. Via GATA6, metastatic cells in the liver upregulate the enzyme aldolase B (ALDOB), which enhances fructose metabolism and provides fuel for major pathways of central carbon metabolism during tumor cell proliferation. Targeting ALDOB or...
TMPH-03387 TSHB Protein, Rat, Recombinant (His & Myc)

Thyrotropin subunit beta,Thyroid-stimulating hormone subunit...

Rat P. pastoris (Yeast)
Indispensable for the control of thyroid structure and metabolism. TSHB Protein, Rat, Recombinant (His & Myc) is expressed in yeast with N-6xHis and C-Myc tag. The predicted molecular weight is 16.4 kDa and the accession number is P04652.
TMPJ-01296 SULT4A1 Protein, Human, Recombinant

hBR-STL,SULTX3,Nervous System Sulfotransferase,SULT4A1,ST4A1...

Human E. coli
Sulfotransferase 4A1 (ST4A1) is a member of the Sulfotransferase 1 family. ST4A1 is highly expressed in the cerebral cortex and frontal lobe, but no expression is detected in the pancreas. ST4A1 is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. ST4A1 acts on catecholamines and T4 in a manner that may not involve sulfonation. ST4A1 may have a role in the metabolism of drugs and neurotransmitters in the CNS. In addition, ST4A1 is related to schizo...
TMPH-02618 CYP2E1 Protein, Mouse, Recombinant (His)

Cyp2e1,Cytochrome P450 2E1,Cytochrome P450-J,4-nitrophenol 2...

Mouse E. coli
A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be invo...
TMPH-01360 GALT Protein, Human, Recombinant (His & SUMO)

Galactose-1-phosphate uridylyltransferase,UDP-glucose--hexos...

Human E. coli
Plays an important role in galactose metabolism. GALT Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 59.4 kDa and the accession number is P07902.
TMPH-02526 Arginase-2/ARG2 Protein, Mouse, Recombinant (His & SUMO)

Arginase II,Kidney-type arginase,Type II arginase,Arg2,Argin...

Mouse E. coli
May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells. May suppress inflammation-related signaling in asthmatic airway epithelium....
TMPH-02685 GPHB5 Protein, Mouse, Recombinant (His & Myc)

Glycoprotein hormone beta-5,Thyrostimulin subunit beta,Gphb5

Mouse E. coli
Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism.
TMPK-00101 IL-6 Protein, Cynomolgus, Recombinant (His)

CDF,BSF-2,白介素,IL6,HGF,白细胞介素,Interleukin-6,HSF,MGI-2A,IFN-β-2...

Cynomolgus HEK293 Cells
IL-6 (Interleukin-6) is a pleiotropic cytokine that acts in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression.Interleukin 6 has been shown to interact with interleukin-6 receptor and glycoprotein.
TMPH-03386 TSHB Protein, Rat, Recombinant (E. coli, His & Myc)

Thyrotropin beta chain,Tshb,Thyrotropin subunit beta,Thyroid...

Rat E. coli
Indispensable for the control of thyroid structure and metabolism. TSHB Protein, Rat, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 19.9 kDa and the accession number is P04652.
TMPY-04771 CARKL Protein, Human, Recombinant (His & GST)

SHK,CARKL,sedoheptulokinase

Human Baculovirus Insect Cells
CARKL, also known as SHPK, is a nonprotein kinase of glucose metabolism. CARKL has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. CARKL catalyzes an orphan reaction in the pentose phosphate pathway, refocusing cellular metabolism to a high-redox state upon physiological or artificial downregulation. CARKL-dependent metabolic reprogramming is required for proper M1- and ...
TMPH-01562 IAPP Protein, Human, Recombinant (GST)

Insulinoma amyloid peptide,IAPP,Islet amyloid polypeptide,Am...

Human E. coli
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. IAPP Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 31.4 kDa and the accession number is P10997.
TMPH-00198 Bet v 3 Protein, Betula pendula, Recombinant (His & Myc & SUMO)

Bet v 3,Allergen Bet v III,BETVIII,Calcium-binding allergen ...

Betula pendula E. coli
Could be involved in calcium metabolism in pollen. Binds 3 calcium ions. Bet v 3 Protein, Betula pendula, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 43.1 kDa and the accession number is P43187.
TMPH-02563 CES1C Protein, Mouse, Recombinant

Es1,PES-N,Liver carboxylesterase N,Carboxylesterase 1C,Lung ...

Mouse E. coli
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Involved in the extracellular metabolism of lung surfactant. CES1C Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 58.6 kDa and the accession number is P23953.
TMPH-00615 RecF Protein, E. coli, Recombinant (His & SUMO)

recF,DNA replication and repair protein RecF

E. coli E. coli
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.
TMPH-01224 Dihydrofolate reductase Protein, Human, Recombinant (His)

DHFR,Dihydrofolate reductase

Human E. coli
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2.
TMPK-00050 Leptin Protein, Mouse, Recombinant (hFc)

LEP,Obesity factor,Leptin,LEPD,Obese protein,OBS,OB

Mouse HEK293 Cells
Leptin has key roles in the regulation of energy balance, body weight, metabolism, and endocrine function. Leptin levels are undetectable or very low in patients with lipodystrophy, hypothalamic amenorrhea, and congenital leptin deficiency (CLD) due to mutations in the leptin gene.
TMPY-02288 Glyoxalase II/HAGH Protein, Human, Recombinant (His)

HAGH1,GLO2,GLX2,hydroxyacylglutathione hydrolase,GLXII

Human E. coli
HAGH (Hydroxyacylglutathione Hydrolase) is a Protein Coding gene. 3 alternative splicing and alternative initiation of human isoforms have been reported. The enzyme encoded by this gene is classified as a thioesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. HAGH belongs to the Metallo-beta-lactamase superfamily. HAGH is widely expressed in the kidney, liver, and other tissues. Diseases associated with HAGH include Hydroxyacyl Glutathio...
TMPH-03535 Dihydrofolate reductase Protein, S. aureus, Recombinant (His & Myc)

DHFR,Dihydrofolate reductase,folA

Staphylococcus aureus E. coli
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Dihydrofolate reductase Protein, S. aureus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 25.6 kDa and the accession number is P99079.
TMPH-01859 PISD Protein, Human, Recombinant (His & SUMO)

PISD,Phosphatidylserine decarboxylase proenzyme, mitochondri...

Human E. coli
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. PISD Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 56.0 kDa and the accession number is Q9UG56.
TMPH-03581 Dihydrofolate reductase Protein, S. epidermidis, Recombinant (His)

dfrC,folA1,Dihydrofolate reductase,folA,DHFR

Staphylococcus epidermidis E. coli
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Dihydrofolate reductase Protein, S. epidermidis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 22.0 kDa and the accession number is P0C0P1.
TMPH-03293 FGF-23 Protein, Rat, Recombinant (E. coli, His)

Fgf23,Fibroblast growth factor 23

Rat E. coli
Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Regulator of vitamin-D metabolism. Negatively regulates osteoblasts differentiation and matrix mineralization. Acts directly on the parathyroid to decrease PTH secretion. Upregulates EGR1 expression in the presence of KL.
TMPH-03021 PstP Protein, Mycobacterium tuberculosis, Recombinant (His)

Mycobacterial Ser/Thr phosphatase,PP2C-family Ser/Thr phosph...

Mycobacterium tuberculosis E. coli
Plays an important role in regulating cell division and growth by reversible phosphorylation signaling. May play important roles in regulating cellular metabolism and signaling pathways, which could mediate the growth and development of the cell. Plays a role in establishing and maintaining infection.
TMPH-02684 GPHB5 Protein, Mouse, Recombinant (His)

Thyrostimulin subunit beta,Glycoprotein hormone beta-5,Gphb5

Mouse P. pastoris (Yeast)
Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism. GPHB5 Protein, Mouse, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 13.3 kDa and the accession number is Q812B2.
TMPH-02582 CELA2A Protein, Mouse, Recombinant (His)

Elastase-2A,ELA2A,CELA2A,Chymotrypsin-like elastase family m...

Mouse E. coli
Elastase that enhances insulin signaling and might have a physiologic role in cellular glucose metabolism. Circulates in plasma and reduces platelet hyperactivation, triggers both insulin secretion and degradation, and increases insulin sensitivity. CELA2A Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 29.7 kDa and the accession number is P05208.
TMPY-01217 ANGPTL5 Protein, Human, Recombinant (GST)

angiopoietin like 5,ANGPTL5

Human Baculovirus Insect Cells
The angiopoietins are protein growth factors that promote angiogenesis, the formation of blood vessels from pre-existing blood vessels. There are now four identified angiopoietins: Ang1, Ang2, Ang3, Ang4. In addition, there are a number of proteins that are closely related to angiopoietins (ANGPTL2, ANGPTL3, ANGPTL4, ANGPTL5, ANGPTL6, ANGPTL7). Angiopoietin-like 5 (ANGPTL5) is mainly expressed in adult heart. Like other members of the angiopoietin family, ANGPTL5-deduced protein also has an N-te...
TMPH-00911 GPT Protein, Human, Recombinant (His)

Glutamic--alanine transaminase 1,Glutamate pyruvate transami...

Human E. coli
Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles. GPT Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 58.5 kDa and the accession number is P24298.
TMPJ-01302 ACAT2 Protein, Human, Recombinant (His)

ACTL,Acetyl-CoA transferase-like protein,Acetyl-CoA acetyltr...

Human E. coli
ACAT2 is a cytoplasmic enzyme which belongs to the thiolase family. ACAT2 takes part in lipid metabolism, lipoprotein assembly, catalyzing cholesterol esterification in mammalian cells. It is responsible for the synthesis of cholesteryl esters which are part of lipoproteins containing apoB. ACAT2 deficiency contributes to severe mental retardation and hypotonus.
TMPH-01087 CSH2 Protein, Human, Recombinant (GST & His)

Chorionic somatomammotropin hormone 2,Lactogen,Choriomammotr...

Human E. coli
Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. CSH2 Protein, Human, Recombinant (GST & His) is expressed in E. coli expression system with N-6xHis-GST tag. The predicted molecular weight is 53.8 kDa and the accession number is P0DML3.
TMPH-01094 CELA2A Protein, Human, Recombinant (His)

Chymotrypsin-like elastase family member 2A,CELA2A,ELA2A,Ela...

Human P. pastoris (Yeast)
Elastase that enhances insulin signaling and might have a physiologic role in cellular glucose metabolism. Circulates in plasma and reduces platelet hyperactivation, triggers both insulin secretion and degradation, and increases insulin sensitivity. CELA2A Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 27.9 kDa and the accession number is P08217.
TMPJ-01248 Cytoglobin/CYGB Protein, Human, Recombinant (His)

Stellate Cell Activation-Associated Protein,Cytoglobin,CYGB,...

Human E. coli
Cytoglobin is a ubiquitously globin protein that belongs to the globin family. The highest expressed in heart, stomach, bladder and small intestine. CYGB acts a protector under conditions of oxidative stress. CYGB may be involved in intracellular oxygen storage or transfer, modulates oxygen and nitric oxide metabolism or scavenging free radicals within a cell.
TMPY-05099 GBA/glucocerebrosidase Protein, Human, Recombinant (His)

glucosidase, β, acid,GLUC,GCB,GBA1,glucosidase, beta, acid

Human HEK293 Cells
Mutations in the GBA gene, encoding the lysosomal hydrolase glucocerebrosidase (GCase), are the most common known genetic risk factor for Parkinson's disease (PD) and dementia with Lewy bodies (DLB). ASAH1 (acid ceramidase 1) and GBA2 (glucocerebrosidase 2) enzymes that mediate glucosylsphingosine production and metabolism are attractive therapeutic targets for treating mutant GBA-associated PD.
TMPK-00764 Apolipoprotein A-II/APOA2 Protein, Human, Recombinant (hFc)

Apolipoprotein A-II(1-76),Apolipoprotein A-II,Apo-AII,APOA2,...

Human HEK293 Cells
APOA2 is a protein implicated in triglyceride, fatty acid and glucose metabolism. In pigs, the APOA2 gene is located on pig chromosome 4 (SSC4) in a QTL region affecting fatty acid composition, fatness and growth traits. Apolipoprotein A-II/APOA2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 36.1 kDa and the accession number is P02652.
TMPK-00795 Apolipoprotein A-II/APOA2 Protein, Mouse, Recombinant (hFc)

APOA2,Apolipoprotein A-II(1-76),Apolipoprotein A-II,Apolipop...

Mouse HEK293 Cells
APOA2 is a protein implicated in triglyceride, fatty acid and glucose metabolism. In pigs, the APOA2 gene is located on pig chromosome 4 (SSC4) in a QTL region affecting fatty acid composition, fatness and growth traits. Apolipoprotein A-II/APOA2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 36.2 kDa and the accession number is P09813.
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重组蛋白

Insulin Protein, Human, Recombinant
Cat.No: TMPY-00395
Species: Human
Expression System: P. pastoris (Yeast)
DEC-205 Protein, Human, Recombinant (His)
Cat.No: TMPY-00322
Species: Human
Expression System: HEK293 Cells
PAH Protein, Human, Recombinant (415 Asn/Asp, His)
Cat.No: TMPY-02707
Species: Human
Expression System: Baculovirus Insect Cells
AFM Protein, Human, Recombinant (His)
Cat.No: TMPY-03962
Species: Human
Expression System: HEK293 Cells
SULT1A1 Protein, Human, Recombinant (His)
Cat.No: TMPY-02062
Species: Human
Expression System: E. coli
AKT1 Protein, Human, Recombinant (His)
Cat.No: TMPY-04552
Species: Human
Expression System: Baculovirus Insect Cells
Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS1 Protein (His)
Cat.No: TMPY-02219
Species: H1N1
Expression System: E. coli
AKR1C4 Protein, Human, Recombinant (His)
Cat.No: TMPY-00481
Species: Human
Expression System: E. coli
GALK2 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01072
Species: Human
Expression System: HEK293 Cells
BST1 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-00516
Species: Cynomolgus
Expression System: HEK293 Cells
IAPP Protein, Human, Recombinant (His)
Cat.No: TMPH-01563
Species: Human
Expression System: P. pastoris (Yeast)
Apolipoprotein A-I/APOA1 Protein, Human, Recombinant
Cat.No: TMPJ-00158
Species: Human
Expression System: E. coli
Metallothionein-4/MT4 Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-01670
Species: Human
Expression System: E. coli
CES1C Protein, Mouse, Recombinant (GST)
Cat.No: TMPH-02561
Species: Mouse
Expression System: E. coli
Dihydrofolate reductase Protein, E. coli, Recombinant (His)
Cat.No: TMPH-00608
Species: E. coli
Expression System: E. coli
CES1C Protein, Mouse, Recombinant (His & Myc)
Cat.No: TMPH-02562
Species: Mouse
Expression System: HEK293 Cells
Apolipoprotein A-V/APOA5 Protein, Mouse, Recombinant (His)
Cat.No: TMPK-01087
Species: Mouse
Expression System: E. coli
Aldolase B Protein, Human, Recombinant (GST)
Cat.No: TMPY-02622
Species: Human
Expression System: E. coli
TSHB Protein, Rat, Recombinant (His & Myc)
Cat.No: TMPH-03387
Species: Rat
Expression System: P. pastoris (Yeast)
SULT4A1 Protein, Human, Recombinant
Cat.No: TMPJ-01296
Species: Human
Expression System: E. coli
CYP2E1 Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02618
Species: Mouse
Expression System: E. coli
GALT Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-01360
Species: Human
Expression System: E. coli
Arginase-2/ARG2 Protein, Mouse, Recombinant (His & SUMO)
Cat.No: TMPH-02526
Species: Mouse
Expression System: E. coli
GPHB5 Protein, Mouse, Recombinant (His & Myc)
Cat.No: TMPH-02685
Species: Mouse
Expression System: E. coli
IL-6 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-00101
Species: Cynomolgus
Expression System: HEK293 Cells
TSHB Protein, Rat, Recombinant (E. coli, His & Myc)
Cat.No: TMPH-03386
Species: Rat
Expression System: E. coli
CARKL Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-04771
Species: Human
Expression System: Baculovirus Insect Cells
IAPP Protein, Human, Recombinant (GST)
Cat.No: TMPH-01562
Species: Human
Expression System: E. coli
Bet v 3 Protein, Betula pendula, Recombinant (His & Myc & SUMO)
Cat.No: TMPH-00198
Species: Betula pendula
Expression System: E. coli
CES1C Protein, Mouse, Recombinant
Cat.No: TMPH-02563
Species: Mouse
Expression System: E. coli
RecF Protein, E. coli, Recombinant (His & SUMO)
Cat.No: TMPH-00615
Species: E. coli
Expression System: E. coli
Dihydrofolate reductase Protein, Human, Recombinant (His)
Cat.No: TMPH-01224
Species: Human
Expression System: E. coli
Leptin Protein, Mouse, Recombinant (hFc)
Cat.No: TMPK-00050
Species: Mouse
Expression System: HEK293 Cells
Glyoxalase II/HAGH Protein, Human, Recombinant (His)
Cat.No: TMPY-02288
Species: Human
Expression System: E. coli
Dihydrofolate reductase Protein, S. aureus, Recombinant (His & Myc)
Cat.No: TMPH-03535
Species: Staphylococcus aureus
Expression System: E. coli
PISD Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-01859
Species: Human
Expression System: E. coli
Dihydrofolate reductase Protein, S. epidermidis, Recombinant (His)
Cat.No: TMPH-03581
Species: Staphylococcus epidermidis
Expression System: E. coli
FGF-23 Protein, Rat, Recombinant (E. coli, His)
Cat.No: TMPH-03293
Species: Rat
Expression System: E. coli
PstP Protein, Mycobacterium tuberculosis, Recombinant (His)
Cat.No: TMPH-03021
Species: Mycobacterium tuberculosis
Expression System: E. coli
GPHB5 Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02684
Species: Mouse
Expression System: P. pastoris (Yeast)
CELA2A Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02582
Species: Mouse
Expression System: E. coli
ANGPTL5 Protein, Human, Recombinant (GST)
Cat.No: TMPY-01217
Species: Human
Expression System: Baculovirus Insect Cells
GPT Protein, Human, Recombinant (His)
Cat.No: TMPH-00911
Species: Human
Expression System: E. coli
ACAT2 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01302
Species: Human
Expression System: E. coli
CSH2 Protein, Human, Recombinant (GST & His)
Cat.No: TMPH-01087
Species: Human
Expression System: E. coli
CELA2A Protein, Human, Recombinant (His)
Cat.No: TMPH-01094
Species: Human
Expression System: P. pastoris (Yeast)
Cytoglobin/CYGB Protein, Human, Recombinant (His)
Cat.No: TMPJ-01248
Species: Human
Expression System: E. coli
GBA/glucocerebrosidase Protein, Human, Recombinant (His)
Cat.No: TMPY-05099
Species: Human
Expression System: HEK293 Cells
Apolipoprotein A-II/APOA2 Protein, Human, Recombinant (hFc)
Cat.No: TMPK-00764
Species: Human
Expression System: HEK293 Cells
Apolipoprotein A-II/APOA2 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPK-00795
Species: Mouse
Expression System: HEK293 Cells
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Cat. No. Product Name Target Signaling Pathways
T19261 D-Glucose-13C6

D-(+)-Glucose-13C6,Glucose-13C6,Dextrose-13C6

Endogenous Metabolite Metabolism
D-Glucose-13C6 (Dextrose-13C6) 是一种 D-Glucose 的同位素标记物,可作为代谢示踪剂,可用于研究机体代谢相关疾病和部分物质的代谢过程。
T9087 Creatine-d3 hydrate

CREATINE-(METHYL-D3) MONOHYDRATE,肌氨酸酐-甲基-D3 一水合物

Endogenous Metabolite Metabolism
Creatine-d3 hydrate (CREATINE-(METHYL-D3) MONOHYDRATE) 是一种氘标记的肌酸水合物。其中肌酸水合物在肌肉和脑细胞的能量代谢中起着关键作用。
T73712 Metformin-d6 hydrochloride

1,1-Dimethylbiguanide-d6 hydrochloride

AMPK; Autophagy Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
Metformin-d6 hydrochloride (Metformin-d6 hydrochloride) 是 Metformin 的一种氘代化物,可用于研究 Metformin 在体内的代谢,常作为Metformin的内标。
T41001 L-Lactic acid-13C3

L-Lactic acid-13C3,(S)-2-hydroxypropanoic-13-C3

L-Lactic acid-13C3 is a stable isotope labeled L-Lactic acid analog. L-Lactic acid-13C3 can be used for lactate metabolism research.
TMIJ-0377 Thiamine Hydrochloride-13C4

Thiamine Hydrochloride-13C4 是 Thiamine Hydrochloride 的 13C 的标记化合物。Thiamine Hydrochloride 的 CAS 号为 67-03-8。Thiamine hydrochloride 是一种必需的微量营养素,是许多中枢代谢酶的辅因子。
TMID-0001 Vitamin K1-d4

Vitamin K1-d4 是 Vitamin K1 的氘代化合物。Vitamin K1 的 CAS 号为 84-80-0。Vitamin K1 (Phylloquinone) 是天然存在的维生素。Vitamin K1是血液凝固,骨和血管代谢所必须的。
TMID-0056 (±)-Mandelic-2,3,4,5,6-d5 Acid

(±)-Mandelic-2,3,4,5,6-d5 Acid 是 (±)-Mandelic Acid 的氘代化合物。(±)-Mandelic Acid 的 CAS 号为 90-64-2。DL-Mandelic acid 是一种 α-羟基羧酸,有抗菌活性,广泛用作医药和精细化学品的中间体,已用于研究尿路感染和阴道滴虫病,还具有较高的精子固定活性和较低的阴道刺激性。
TMIJ-0373 Biotin-d2

Biotin-d2 是 Biotin 的氘代化合物。Biotin 的 CAS 号为 58-85-5。Biotin 是一种水溶性B族维生素,是细胞生长、脂肪酸产生以及脂肪和氨基酸代谢所必需的。
TMID-0060 Methylcobalamin-13C-d3

Methylcobalamin-13C-d3 是 Methylcobalamin 的 13C 和氘代化合物。Methylcobalamin 的 CAS 号为 13422-55-4。Methylcobalamin 是维生素B12的一种形式,可直接参与同型半胱氨酸代谢。
TMIH-0368 Naringenin-d4

Naringenin-d4 是 Naringenin 的氘代化合物。Naringenin 的 CAS 号为 480-41-1。Naringenin是葡萄柚中主要的黄烷酮,可作为抗氧化剂、自由基清除剂、抗炎剂、碳水化合物代谢促进剂、免疫系统调节剂。
TMIJ-0094 Trimetazidine-d8 Dihydrochloride

Trimetazidine-d8 Dihydrochloride 是 Trimetazidine Dihydrochloride 的氘代化合物。Trimetazidine Dihydrochloride 的 CAS 号为 13171-25-0。Trimetazidine dihydrochloride 是细胞保护性抗缺血剂,也用作缺血性心脏病或心绞痛的血管扩张剂,具有抗氧化,抗炎,抗伤害和胃保护作用。它可通过抑制脂肪酸代谢提高心肌葡萄糖利用率。
T35698 Octanoic Acid-13C

Octanoic acid-13C is intended for use as an internal standard for the quantification of octanoic acid by GC- or LC-MS. Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from goat, ovine, or bovine milk.1 Octanoic acid is active against the bacteria S. mutans, S. gordonii, F. nucleatum, and P. gingivalis (IC80s = <125, <125, 1,403, and 2,294 μM, respectively).2 Levels of octanoic acid are increased in the plasma of patients with medium-chain acyl-CoA d...
TMID-0104 L-Thyroxine-13C6

L-Thyroxine-13C6 是 L-Thyroxine 的 13C 的标记化合物。L-Thyroxine 的 CAS 号为 51-48-9。L-Thyroxine (T4)是一种合成的甲状腺激素,用于甲状腺功能减退症的研究。在DIO 酶作用下, L-Thyroxine (T4)转化成具有生物特性的三碘甲状腺氨酸 (T3)。
TMIH-0030 2,2,14,14-tetramethyl-8-oxopentadecanedioic acid-d4

Bempedoic Acid Impurity 1-d4

2,2,14,14-tetramethyl-8-oxopentadecanedioic acid-d4 是 2,2,14,14-tetramethyl-8-oxopentadecanedioic acid 的氘代化合物。2,2,14,14-tetramethyl-8-oxopentadecanedioic acid 的 CAS 号为 413624-71-2。2,2,14,14-Tetramethyl-8-oxopentadecanedioic acid 属于酮类化合物,详细信息请参考专利文献 WO2002030860A2,化合物 II-9。它在心血管疾病、血脂异常、蛋白异常和糖代谢紊乱方面具有研究的价值。
TMIH-0028 2-(1-(methyl-d3)-1H-imidazol-4-yl)ethan-1-amine 2HCl

1-Methylhistamine-d3 Dihydrochloride

2-(1-(methyl-d3)-1H-imidazol-4-yl)ethan-1-amine 2HCl 是 2-(1-(methyl)-1H-imidazol-4-yl)ethan-1-amine 2HCl 的氘代化合物。2-(1-(methyl)-1H-imidazol-4-yl)ethan-1-amine 2HCl 的 CAS 号为 6481-48-7。1-Methylhistamine dihydrochloride 是组胺代谢物。
TMIH-0109 Bempedoic acid-d4

Bempedoic acid-d4 是 Bempedoic acid 的氘代化合物。Bempedoic acid 的 CAS 号为 738606-46-7。ETC-1002 是一种 ATP-柠檬酸裂解酶抑制剂,可激活AMPK。它是脂质和碳水化合物代谢的调节剂。
TMIJ-0372 L-Threonine-d2

L-Threonine-d2 是 L-Threonine 的氘代化合物。L-Threonine 的 CAS 号为 72-19-5。L-Threonine 是人体必需氨基酸,是神经系统的重要氨基酸。L-Threonine 在卟啉和脂肪代谢中也起着重要作用,防止肝脏脂肪堆积。L-Threonine 可用于治疗肠道疾病和消化不良,也可用于缓解焦虑和轻度抑郁。
TMIH-0530 Sulbactam-d2

Sulbactam-d2 是 Sulbactam 的氘代化合物。Sulbactam 的 CAS 号为 68373-14-8。Sulbactam是一种竞争性、不可逆的 β-内酰胺酶抑制剂,抑制耐多药不动杆菌-鲍曼不动杆菌复合物。它具有抗菌活性。
TMID-0097 Ethyl-d5-malonic Acid

Ethyl-d5-malonic Acid 是 Ethyl-malonic Acid 的氘代化合物。Ethyl-malonic Acid 的 CAS 号为 601-75-2。Ethylmalonic acid 是潜在有毒物质,非致癌性,与神经性厌食和甲氧基脱羧酶缺乏症有关。
TMID-0167 6-Hydroxypurine-d4

6-Hydroxypurine-d4 是 6-Hydroxypurine 的氘代化合物。6-Hydroxypurine 的 CAS 号为 68-94-0。Hypoxanthine,也被称为 purine-6-ol 或 Hyp,属于嘌呤类有机化合物。Hypoxanthine 是一种天然存在的嘌呤衍生物,是腺苷代谢和核苷酸补救途径形成核酸的反应中间体。在正常情况下,Hypoxanthine 很容易转化为尿酸。Hypoxanthine 首先被氧化为黄嘌呤,黄嘌呤再被黄嘌呤氧化酶氧化为尿酸。
TMIJ-0047 Isobutyric-d6 acid

Isobutyric-d6 acid 是 Isobutyric acid 的氘代化合物。Isobutyric acid 的 CAS 号为 79-31-2。Isobutyric acid 是一种羧酸或短链脂肪酸,具有特征性的汗味。通过微生物(肠道)代谢产生少量异丁酸。在某些食物或发酵饮料中也可能发现少量。
TMIJ-0053 2-Methylpropionic-d7 acid

2-Methylpropionic-d7 acid 是 2-Methylpropionic acid 的氘代化合物。2-Methylpropionic acid 的 CAS 号为 79-31-2。Isobutyric acid 是一种羧酸或短链脂肪酸,具有特征性的汗味。通过微生物(肠道)代谢产生少量异丁酸。在某些食物或发酵饮料中也可能发现少量。
TMIJ-0384 L-Cysteine-d3

L-Cysteine-d3 是 L-Cysteine 的氘代化合物。L-Cysteine 的 CAS 号为 52-90-4。L-Cysteine 是人体非必需的含硫氨基酸。L-Cysteine 对蛋白质合成、解毒和多种代谢功能很重要。L-Cysteine 存在于指甲、皮肤和头发的主要蛋白质-角蛋白中,对胶原蛋白的生成、皮肤弹性和质地都很重要。L-Cysteine 是抗氧化剂谷胱甘肽的一种成分,在辅酶A、肝素和生物素等基本生化物质的代谢中起着重要作用,也是氨基酸牛磺酸的制造所必需的。
T36384 DL-Tyrosine-13C9,15N

L-Tyrosine-13C9,15N

L-Tyrosine-13C9,15N is intended for use as an internal standard for the quantification of L-tyrosine by GC- or LC-MS. L-Tyrosine is a non-essential amino acid.1It is produced by hydroxylation of phenylalanine by phenylalanine hydroxylase but can also be obtained from dietary sources or degradation of endogenous proteins, resulting in L-tyrosine release.1,2L-Tyrosine is a precursor in the biosynthesis of catecholamine neurotransmitters, melanins, and thyroid hormones.3Plasma, skeletal muscle, and...

同位素标记化合物

D-Glucose-13C6
Cat.No: T19261
Synonym: D-(+)-Glucose-13C6,Glucose-13C6,Dextrose-13C6
Target: Endogenous Metabolite
Creatine-d3 hydrate
Cat.No: T9087
Synonym: CREATINE-(METHYL-D3) MONOHYDRATE,肌氨酸酐-甲基-D3 一水合物
Target: Endogenous Metabolite
Metformin-d6 hydrochloride
Cat.No: T73712
Synonym: 1,1-Dimethylbiguanide-d6 hydrochloride
Target: AMPK, Autophagy
L-Lactic acid-13C3
Cat.No: T41001
Synonym: L-Lactic acid-13C3,(S)-2-hydroxypropanoic-13-C3
Target:
Thiamine Hydrochloride-13C4
Cat.No: TMIJ-0377
Synonym:
Target:
Vitamin K1-d4
Cat.No: TMID-0001
Synonym:
Target:
(±)-Mandelic-2,3,4,5,6-d5 Acid
Cat.No: TMID-0056
Synonym:
Target:
Biotin-d2
Cat.No: TMIJ-0373
Synonym:
Target:
Methylcobalamin-13C-d3
Cat.No: TMID-0060
Synonym:
Target:
Naringenin-d4
Cat.No: TMIH-0368
Synonym:
Target:
Trimetazidine-d8 Dihydrochloride
Cat.No: TMIJ-0094
Synonym:
Target:
Octanoic Acid-13C
Cat.No: T35698
Synonym:
Target:
L-Thyroxine-13C6
Cat.No: TMID-0104
Synonym:
Target:
2,2,14,14-tetramethyl-8-oxopentadecanedioic acid-d4
Cat.No: TMIH-0030
Synonym: Bempedoic Acid Impurity 1-d4
Target:
2-(1-(methyl-d3)-1H-imidazol-4-yl)ethan-1-amine 2HCl
Cat.No: TMIH-0028
Synonym: 1-Methylhistamine-d3 Dihydrochloride
Target:
Bempedoic acid-d4
Cat.No: TMIH-0109
Synonym:
Target:
L-Threonine-d2
Cat.No: TMIJ-0372
Synonym:
Target:
Sulbactam-d2
Cat.No: TMIH-0530
Synonym:
Target:
Ethyl-d5-malonic Acid
Cat.No: TMID-0097
Synonym:
Target:
6-Hydroxypurine-d4
Cat.No: TMID-0167
Synonym:
Target:
Isobutyric-d6 acid
Cat.No: TMIJ-0047
Synonym:
Target:
2-Methylpropionic-d7 acid
Cat.No: TMIJ-0053
Synonym:
Target:
L-Cysteine-d3
Cat.No: TMIJ-0384
Synonym:
Target:
DL-Tyrosine-13C9,15N
Cat.No: T36384
Synonym: L-Tyrosine-13C9,15N
Target:
TargetMol Loading
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