Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T21995 |
XAP044
|
GluR | Neuroscience |
XAP044 是高效的选择性mGlu7拮抗剂。代谢型谷氨酸受体亚型 7 是哺乳动物 CNS 中神经传递的重要突触前调节剂。它在啮齿动物行为测试中表现出较好的大脑暴露、广谱抗应激、抗抑郁以及抗焦虑作用。 | |||
T13321 |
VU6005649
|
GluR | Neuroscience |
VU6005649 是一种中枢神经系统渗透性的mGlu7/8受体激动剂,对于mGlu7受体和mGlu8受体的EC50分别为 0.65 μM 和 2.6 μM。 | |||
T13323 |
VU6012962
|
GluR | Neuroscience |
VU6012962 是一种可渗透 CNS ,可口服的代谢型谷氨酸受体 7 阴性变构调节剂,IC50为 347 nM。 | |||
T6726 |
VU0361737
ML-128,VU 0361737 |
GluR | Neuroscience |
VU0361737 (ML-128) 是一种高效选择性的,中枢神经系统渗透性的代谢型谷氨酸受体 4(mGluR4)正变构调节剂,对人类和大鼠 mGluR4作用的EC50值分别为 240 和 110 nM。它具有神经保护作用,有用于帕金森氏病的研究潜力。 | |||
T23008 |
MMPIP
MMPIP hydrochloride |
Others | Others |
allosteric mGlu7-selective receptor antagonist | |||
T15692 |
L-AP4
L-APB,L-AP 4 |
GluR | Neuroscience |
L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively). | |||
T35082 |
VU6010608
VU-6010608,VU 6010608 |
Others | Others |
VU6010608 is an effective mGlu7 NAM with excellent CNS permeability and is powerful in electrophysiological studies in blocking long-term enhancement of high-frequency stimuli. | |||
T21935 |
AMN082
AMN 082 dihydrochloride |
GluR | Neuroscience |
AMN082 (AMN 082 dihydrochloride) 是可口服,可透过血脑屏障的选择性mGluR7激动剂,通过跨膜区的变构位点直接激活受体信号,具有抗抑郁作用。 | |||
T37127 |
L-AP4 monohydrate
L-AP4 monohydrate |
Others | Others |
L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively[1][2]. L-AP4 (5-30 μg, intrathecal inhection 4-5 days) significantly increases the paw withdrawal threshold in response to application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner. Intrathecal administration of different doses of L-AP4 is not associated with any evident motor dysfunctio... |