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Search Results for " m6a "

Targets Recommended: Apoptosis Others

抑制剂 & 化合物

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7138	FB23-2	Apoptosis; Others	Apoptosis; Others
	FB23-2 是一种 mRNA N6- 甲基腺嘌呤脱甲基酶 FTO 选择性抑制剂，IC50值为 2.6 μM。它具有抗增殖作用，可研究急性髓系白血病。
T74474	m7Gpppm6AmpG ammonium	Others	Others
	m7Gppm6AmpG ammonium 是一种三核苷酸 mRNA 5' 帽类似物，可用于体外 RNA 的合成。
T74473	m7Gpppm6AmpG	Others	Others
	m7Gppm6AmpG 是一种三核苷酸 mRNA 5' 帽类似物，可用于体外 RNA 合成。
T8874	FB23	Others	Others
	FB23 是FTO 去甲基化酶选择性抑制剂(IC50:60 nM)。它能够直接与FTO 结合，选择性的抑制FTO 的 mRNA N6-甲基腺嘌呤脱甲基酶活性。
T67930L	CWI1-2 HCL	Apoptosis	Apoptosis
	CWI1-2 HCL 是一种有效的 IGF2BP2 抑制剂，结合 IGF2BP2 并抑制其与 m6A 修饰的靶转录物的相互作用，可诱导细胞凋亡和分化，具有治疗白血病的作用。
T67930	CWI1-2	Apoptosis	Apoptosis
	CWI1-2 是一种有效的 IGF2BP2 抑制剂，通过结合 IGF2BP2 抑制其与 m6A 修饰的靶转录物的相互作用。CWI1-2 具有抗白血病活性，可诱导细胞凋亡 (apoptosis)和分化。
T37198	Ethyl LipotF	Others	Others
	Selective FTO inhibitor (IC50 = 0.81 μM). Exhibits >30-fold selectivity for FTO over ALKBH2, 3 and 5 and >100-fold selectivity over PHD2 and JMJD2A. Increases levels of modified N6-methyladenosine (m6A) in HeLa cells in a concentration-dependent manner.
T37447	UZH1 UZH1	Others	Others
	UZH1 is a racemate of UZH1a and UZH1b. UZH1a is a potent and selective METTL3 inhibitor, with an IC50 of 280 nM. UZH1b (IC50=28 μM) is essentially inactive. UZH1 can be used for epitranscriptomic modulation of cellular processes. UZH1 has antitumor activity. UZH1 also can be used as a chemical probe for studying METTL3[1]. UZH1a (2.5-160 μM; 72 h) inhibits the growth of MOLM-13, HEK293T, and U2Os cells, with IC50s of 11 μM, 67 μM, and 87 μM, respectively[1].UZH1b (2.5-160 μM; 72 h) inhibits the ...

化合物

FB23-2

Cat.No: T7138

Synonym:

Target: Apoptosis, Others

m7Gpppm6AmpG ammonium

Target: Apoptosis

CWI1-2

Cat.No: T67930

Synonym:

Target: Apoptosis

Cat. No.	Product Name	Target	Signaling Pathways
T6599	N6-methyladenosine N6-甲基腺苷,N-Methyladenosine,6-Methyladenosine,NSC-29409,m6A	Others; Influenza Virus; Endogenous Metabolite	Metabolism; Microbiology/Virology; Others
	N6-Methyladenosine 是甲基化的腺嘌呤残基，苷是转移核糖核酸降解的内源性尿核苷产物。它是存在于所有高等真核生物中最普遍的的信使 RNA 内部修饰，可修饰病毒 RNA，有抗病毒活性。

天然产物

N6-methyladenosine

Cat.No: T6599

Synonym: N6-甲基腺苷,N-Methyladenosine,6-Methyladenosine,NSC-29409,m6A

Target: Others, Influenza Virus, Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02317	YTHDF1 Protein, Human, Recombinant (His) YTHDF1,Dermatomyositis associated with cancer putative autoa...	Human	P. pastoris (Yeast)
	Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and regulates their stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex. The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) shares m6A-containing mRNAs targets and act redundantly to mediate mRNA degradatio...

重组蛋白

YTHDF1 Protein, Human, Recombinant (His)

Cat.No: TMPH-02317

Species: Human

Expression System: P. pastoris (Yeast)

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