首页工具

登录

搜索结果

Search Results for " lysosome "

Targets Recommended: Others

31

抑制剂 & 化合物

5

天然产物

1

化合物库

20

重组蛋白

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name
L8600	泛素化化合物库		210 compounds
	210 种泛素化相关的小分子，用于高通量和高内涵筛选；

化合物库

泛素化化合物库

Cat.No: L8600

Compounds: 210

Cat. No.	Product Name	Target	Signaling Pathways
T8549	HEPES	Others	Others
	HEPES 是两性离子化学缓冲剂，在 pH 值为 6.8 至 8.2 时为有效的缓冲液，广泛应用于细胞培养。它是溶酶体生物发生的有效诱导剂。
T24477	MK6-83 MK683	TRP/TRPV Channel	Membrane transporter/Ion channel
	MK6-83 是有效的TRPML1的候选激动剂，具有优越的活性。它在IV 型粘脂病中具有研究的价值。
T4989	Fosfomycin Tromethamine	Antibacterial; Antibiotic	Microbiology/Virology
	Fosfomycin tromethamine 是一种能透过血脑屏障的广谱抗生素，不可逆地抑制细胞壁合成的早期阶段。它对多种细菌具有杀菌活性，包括耐多药、广泛耐药和耐全药细菌。
T3131	Fosfomycin calcium Phosphomycin calcium salt,Fosmicin,磷霉素钙	Antibacterial; Antibiotic	Microbiology/Virology
	Fosfomycin calcium (Phosphomycin calcium salt) 是一种能透过血脑屏障的广谱抗生素，不可逆地抑制细胞壁合成的早期阶段。它对多种细菌具有杀菌活性，包括耐多药、广泛耐药和耐全药细菌。
T1090	Perphenazine Perphenazin,Etaperazine,Trilafon,奋乃静	CaMK; Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Perphenazine (Trilafon) 是吩噻嗪衍生物和多巴胺拮抗剂，具有止吐和抗精神病特性。它能够抑制5-HT2A 受体，α1A 肾上腺素能受体，多巴胺D2、D3、D2L 受体，以及组胺H1受体，对应的Ki 值分别为5.6、10、0.765、0.13、3.4 和 8 nM。
T39370	tri-GalNAc-COOH	LYTACs	PROTAC
	Tri-GalNAc-COOH is a ligand for the asialoglycoprotein receptor (ASGPR) commonly employed in Lysosome Targeting Chimera (LYTAC) investigations.
T9957	LASV inhibitor 3.3	Virus Protease	Microbiology/Virology
	LASV inhibitor 3.3 是一种针对溶酶体相关膜蛋白 1 (LAMP1) 的拉沙热病毒 (LASV) 抑制剂，LAMP1 是一种在感染期间与 LASV 糖蛋白 (GP) 结合的宿主因子。
T12038	Migalastat hydrochloride GR181413A hydrochloride,Migalastat HCl,GR181413A HCl	Others	Others
	Migalastat hydrochloride (GR181413A) 是一种可口服且具有有效和竞争性的 α-galactosidase A 抑制剂，可促进α-半乳糖苷酶A向溶酶体的运输，可用于研究法布里病。
T5181	CA-5f	Apoptosis; Autophagy	Apoptosis; Autophagy
	CA-5f 是晚期巨自噬/自噬抑制剂，通过抑制自噬体-溶酶体融合起作用。它能够增加监控自噬的标记物 LC3B-II 和 SQSTM1 蛋白水平，促进 ROS 的产生，具有抗肿瘤活性。
T72057	H1k	CDK	Cell Cycle/Checkpoint
	H1k 是一种 eudistomin Y 荧光衍生物和溶酶体靶向抗增殖剂。它可以剂量依赖性地增加自噬信号，下调细胞周期蛋白依赖性激酶(cyclin-dependent kinase, CDK1)和细胞周期蛋白 B1的表达。
T22839	HEPES Sodium	Others	Others
	HEPES Sodium salt 是一种非挥发性两性离子化学缓冲剂。HEPES 钠盐在细胞培养中有着广泛的应用。HEPES Sodium salt 在 pH 6.8至8.2时有效。HEPES Sodium salt 也诱导溶酶体的生物发生。
T8990	ML266	Glucokinase	Metabolism
	ML266 是葡萄糖脑苷脂酶 (GCase) 分子伴侣， IC50值为 2.5 µM。ML266与 GCase 结合并将其转运至溶酶体，恢复 GCase 酶的活性。ML266 不会抑制 GCase 的活性。ML266 具有研究戈谢病的潜力。
T3437	Lys05 Lys01 trihydrochloride	lysosomal autophagy; Autophagy	Autophagy
	Lys05 是一种有效的水溶性溶酶体自噬抑制剂，具有抗肿瘤活性。在 MTT 试验中，对1205Lu、c8161、LN229 和 HT-29细胞系的IC50值分别为3.6、3.8、6 和7.9 μM。
T73550	CUR5g	Others	Others
	CUR5g 是一种有效的自噬 (autophagy) 抑制剂。CUR5g 通过阻断自噬体-溶酶体融合选择性地抑制癌细胞中的自噬体降解。CUR5g 通过依赖 UVRAG 的机制阻止 STX17 募集到自噬体，导致自噬体无法与溶酶体融合。CUR5g 可提高顺铂 (Cisplatin) 在体外和体内对 A549 细胞的抗癌作用。
T111959	IFB-088 acetate	Others	Others
	IFB-088 acetate 是一种苄基胍衍生物，可用于治疗与PPP1R15A 途径相关并与蛋白质错误折叠应激相关的疾病和癌症，如tau 病、突触核蛋白病、多谷氨酰胺和多丙氨酸疾病、白质营养不良、囊性纤维化、多发性硬化症、溶酶体储存障碍、淀粉样变性疾病、炎症、代谢障碍、心血管疾病、骨质疏松症、神经系统创伤等等。
T11191	EN6	Proton pump; Autophagy	Autophagy; Membrane transporter/Ion channel
	EN6 是一种小分子体内自噬激活剂，其共价靶向溶酶体v-ATP 酶的 ATP6V1A 亚基中的半胱氨酸 277。它以溶酶体依赖性方式清除 TDP-43 聚集体，这是额颞叶痴呆的病原体。它介导的 ATP6V1A 修饰使 v-ATP 酶与 Rags 分离，从而抑制 mTORC1 信号传导、增加溶酶体酸化和激活自噬。
T23978	Deox B 7,4 Deoxysappanone-B-7,4 dimethyl ether,Deox-B-7,4,Deoxysappanone B 7,4 dimethyl ether,DeoxB7,4	Others	Others
	Deox B 7,4 is a reversible microtubule inhibitor that acts by increasing lysosomal V-ATPase activity and lysosome acidity.
T77946	Tri-GalNAc(OAc)3	LYTACs	PROTAC
	Tri-GalNAc(OAc)3为一tri-GalNAc配体，用于GalNAc-LYTAC合成，该合成物通过靶向去唾液酸糖蛋白受体实施蛋白降解。
T77941	tri-GalNAc biotin	LYTACs	PROTAC
	tri-GalNAc biotin是一种针对降解物的小分子溶酶体靶向化合物，作为ASGPR（肝脏糖蛋白受体）的配体，它促进肝细胞通过ASGPR吸收中性抗生物素蛋白（NA），并将其运送至溶酶体内降解。该化合物适用于LYTAC（溶酶体靶向嵌合体）的研究。
T80947	tri-GalNAc-COOH (acetylation)	LYTACs	PROTAC
	Tri-GalNAc-COOH acetylation 是一种对 tri-GalNAc-COOH 进行乙酰化和修饰的过程，该过程可用于LYTAC的合成。
T81671	Nitro-coronene	Others	Others
	Nitro-coronene用于制备近红外光触发的溶酶体靶向碳点，适用于癌症光热疗法研究。
T77935	Tri-GalNAc(OAc)3-Perfluorophenyl	LYTACs	PROTAC
	Tri-GalNAc(OAc)3-Perfluorophenyl 为五氟苯基修饰的 Tri-GalNAc(OAc)3，属 tri-GalNAc 配体类，用于 GalNAc-LYTAC 合成。该 GalNAc-LYTAC 通过去唾液酸糖蛋白受体实现靶向蛋白降解。
T77947	Tri-GalNAc(OAc)3 TFA	LYTACs	PROTAC
	Tri-GalNAc(OAc)3 TFA为一种tri-GalNAc配体，用于GalNAc-LYTAC合成，后者通过靶向去唾液酸糖蛋白受体实现蛋白降解。
T35747	Quinacrine analog 34	Others	Others
	Quinacrine is a compound with multiple actions that is commonly used as an anti-protozoal agent. It has also been shown to be a highly potent autophagy inhibitor, although the dose required to achieve this effect is considerably cytotoxic (LD50 = 2.5 μM). Quinacrine analog 34 is a derivative of quinacrine that was designed with an improved cell viability profile (LD50 = 27 μM) to inhibit autophagy. At a minimum concentration of 0.5 μM, this compound has been shown to increase the protein levels ...
T80946	Tri-GalNAc-NHS ester	LYTACs	PROTAC
	Tri-GalNAc-NHS ester 是一种LYTAC，特别作为asialoglycoprotein receptor (ASGPR) 的配体，后者是肝细胞特有、参与细胞外包括膜蛋白在内的蛋白质降解的溶酶体靶向受体。该化合物在利用LYTAC进行蛋白质降解研究中扮演关键角色。
T63488	TCMDC-135051 hydrochloride	Others	Others
	TCMDC-135051 hydrochloride 是有效的、高度选择性的、低的靶外毒性的蛋白激酶 PfCLK3 抑制剂。TCMDC-135051 hydrochloride 能够阻断滋养体到裂殖体的转变，破坏转录并抑制向蚊子载体的传播，表现出具有抗寄生虫效果，其EC50值为320 nM。
T74633	MS9427	Others	Others
	MS9427 是一种有效的PROTACEGFR 降解剂，对野生型EGFR 和突变型EGFRL858R 的Kd 分别为 7.1 nM 和 4.3 nM。MS9427 通过泛素/蛋白酶体系统 (UPS) 和自噬/溶酶体途径选择性地降解突变体，但不降解WTEGFR。MS9427 对 NSCLC 细胞增殖有较强的抑制作用。MS9427 可用于抗癌研究。
T72543	BOLD-100 free base NKP-1339 free base ; IT-139 free base ; KP-1339 free base,KP-1339 free base,NKP-1339 free base,IT-139 free base	Others	Others
	BOLD-100 (NKP-1339; IT-139) free base 是一款钌基抗癌药物。作为GRP78应激诱导上调的抑制剂，它破坏内质网(ER)的稳态，从而诱发ER应激和未折叠蛋白反应(UPR)。此外，BOLD-100 free base 干预了内质网应激反应、溶酶体动力学以及细胞自噬(autophagy)间的复杂交互作用。
T74635	MS9449	PROTACs	PROTAC
	MS9449 是一种高效的 PROTAC EGFR 降解剂，其对野生型 EGFR 和突变型 EGFR L858R 的 Kd 值分别为 17 nM 和 10 nM。该化合物通过 UPS (泛素/蛋白酶体系统) 和自噬/溶酶体途径，有效促进突变型 EGFRs 的降解，并对 NSCLC（非小细胞肺癌）细胞增殖显示出显著的抑制效果，适用于抗癌研究。
T74634	MS9427 TFA	PROTACs	PROTAC
	MS9427 TFA 是一种有效的 PROTACEGFR 降解剂，对野生型 EGFR 和突变型 EGFRL858R 的 Kd 分别为 7.1 nM 和 4.3 nM。MS9427 TFA 通过泛素/蛋白酶体系统 (UPS) 和自噬/溶酶体途径选择性地降解突变体，但不降解 WTEGFR。MS9427 TFA 对 NSCLC 细胞增殖有较强的抑制作用。MS9427 TFA 可用于抗癌研究。
T35639	Sulfatides (bovine) (sodium salt)
	Sulfatides are endogenous sulfoglycolipids with various biological activities in the central and peripheral nervous systems, pancreas, and immune system. They are produced from the combination of ceramide and UDP-galactose in the endoplasmic reticulum followed by sulfation in the Golgi apparatus. The ceramide portion contains variable fatty acid chain lengths, which are tissue- and pathology-dependent. Sulfatides are primarily found in the myelin sheath of oligodendrocytes and Schwann cells, wit...

化合物

Cat.No: T8549

Target: Others

Cat.No: T24477

Synonym: MK683

Target: TRP/TRPV Channel

Fosfomycin Tromethamine

Cat.No: T4989

Target: Antibacterial, Antibiotic

Fosfomycin calcium

Cat.No: T3131

Synonym: Phosphomycin calcium salt,Fosmicin,磷霉素钙

Target: Antibacterial, Antibiotic

Cat.No: T1090

Synonym: Perphenazin,Etaperazine,Trilafon,奋乃静

Target: CaMK, Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, Histamine Receptor

tri-GalNAc-COOH

Cat.No: T39370

Target: LYTACs

LASV inhibitor 3.3

Cat.No: T9957

Target: Virus Protease

Migalastat hydrochloride

Cat.No: T12038

Synonym: GR181413A hydrochloride,Migalastat HCl,GR181413A HCl

Target: Others

Cat.No: T5181

Target: Apoptosis, Autophagy

Cat.No: T72057

Target: CDK

Cat.No: T22839

Target: Others

Cat.No: T8990

Target: Glucokinase

Cat.No: T3437

Synonym: Lys01 trihydrochloride

Target: lysosomal autophagy, Autophagy

Cat.No: T73550

Target: Others

IFB-088 acetate

Cat.No: T111959

Target: Others

Cat.No: T11191

Target: Proton pump, Autophagy

Cat.No: T23978

Synonym: Deoxysappanone-B-7,4 dimethyl ether,Deox-B-7,4,Deoxysappanone B 7,4 dimethyl ether,DeoxB7,4

Target: Others

Tri-GalNAc(OAc)3

Cat.No: T77946

Target: LYTACs

tri-GalNAc biotin

Cat.No: T77941

Target: LYTACs

tri-GalNAc-COOH (acetylation)

Cat.No: T80947

Target: LYTACs

Cat.No: T81671

Target: Others

Tri-GalNAc(OAc)3-Perfluorophenyl

Cat.No: T77935

Target: LYTACs

Tri-GalNAc(OAc)3 TFA

Cat.No: T77947

Target: LYTACs

Quinacrine analog 34

Cat.No: T35747

Target: Others

Tri-GalNAc-NHS ester

Cat.No: T80946

Target: LYTACs

TCMDC-135051 hydrochloride

Cat.No: T63488

Target: Others

Cat.No: T74633

Target: Others

BOLD-100 free base

Cat.No: T72543

Synonym: NKP-1339 free base ; IT-139 free base ; KP-1339 free base,KP-1339 free base,NKP-1339 free base,IT-139 free base

Target: Others

Cat.No: T74635

Target: PROTACs

Cat.No: T74634

Target: PROTACs

Sulfatides (bovine) (sodium salt)

Cat.No: T35639

Cat. No.	Product Name	Target	Signaling Pathways
T5S1099	Liensinine	Apoptosis; Mitophagy; Others; Autophagy	Apoptosis; Autophagy; Others
	Liensinine 是一种自噬/线粒体自噬抑制剂。Liensinine 是从芙蕖种子胚中提取的，一种主要的异喹啉生物碱，具抗心律不齐、抗高血压、抗肺纤维化、血管平滑肌松弛等广泛的生物活性。
T8262	Fosfomycin sodium Fosfomycin Disodium,磷霉素钠	Antibacterial; Antibiotic	Microbiology/Virology
	Fosfomycin sodium 是一种能透过血脑屏障的广谱抗生素，不可逆地抑制细胞壁合成的早期阶段。它对多种细菌具有杀菌活性，包括耐多药、广泛耐药和耐全药的细菌。
T2S1837	Steviol 甜菊醇,NSC 226902,Hydroxydehydrostevic acid	Others	Others
	Steviol (NSC-226902) 是一种甜菊糖甙的主要代谢物。它能降低 AQP2 的表达，并促进 AQP2 的降解，从而减缓肾囊肿的生长。
T4S1102	Liensinine diperchlorate 莲心碱高氯酸盐,莲心碱二高氯酸盐,Liensinine-Perchlorate	Mitophagy; Others; Autophagy	Autophagy; Others
	Liensinine Diperchlorate 是从芙蕖种子胚中提取的一种异喹啉生物碱。它通过阻断自噬小体-溶酶体融合来抑制晚期自噬，具有抗心律不齐、抗高血压、抗肺纤维化和血管平滑肌松弛等生物学活性。
T82428	Euphorblin R EOF2
	Euphorblin R (EOF2)为鼠李叶烷二萜类化合物，从龙骨木 (Euphorbia resinifera) 中分离。该化合物或促进溶酶体生物合成，具研究溶酶体相关疾病潜力。

天然产物

Cat.No: T5S1099

Target: Apoptosis, Mitophagy, Others, Autophagy

Fosfomycin sodium

Cat.No: T8262

Synonym: Fosfomycin Disodium,磷霉素钠

Target: Antibacterial, Antibiotic

Cat.No: T2S1837

Synonym: 甜菊醇,NSC 226902,Hydroxydehydrostevic acid

Target: Others

Liensinine diperchlorate

Cat.No: T4S1102

Synonym: 莲心碱高氯酸盐,莲心碱二高氯酸盐,Liensinine-Perchlorate

Target: Mitophagy, Others, Autophagy

Cat.No: T82428

Synonym: EOF2

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00299	LIMPII/SR-B2 Protein, Mouse, Recombinant (hFc) LIMP II,Lysosome membrane protein II,SCARB2,85 kDa ...	Mouse	HEK293 Cells
	Lysosome membrane protein II (LIMPII)，also known as SCARB2, is a type III multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far examined. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junc...
TMPJ-00264	LAMP1 Protein, Human, Recombinant (hFc) LAMP-1,CD107a,Lysosome-Associated Membrane Glycopro...	Human	HEK293 Cells
	Lysosome-Associated Membrane Glycoprotein 1 (LAMP1) is a single-pass type I membrane protein belonging to the LAMP family. LAMP1 is expressed largely in the endosome-lysosome membranes of cells.It shuttles between lysosomes, endosomes, and the plasma membrane. LAMP1 functions to present carbohydrate ligands to selectins and it has also been implicated in tumor cell metastasis. It has been proposed LAMP1 can be used as a therapeutic agent for certain cancers, as well as a marker for lysosomal sto...
TMPH-03324	LIMPII/SR-B2 Protein, Rat, Recombinant (His & Myc) 85 kDa lysosomal membrane sialoglycoprotein,Scarb2,CD36 anti...	Rat	E. coli
	Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting. LIMPII/SR-B2 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 53.7 kDa and the accession number is P27615.
TMPH-03146	LAMP5 Protein, Pongo abelii, Recombinant (His & Myc) Lysosome-associated membrane glycoprotein 5,LAMP5,B...	Pongo abelii	E. coli
	Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain. LAMP5 Protein, Pongo abelii, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 30.4 kDa and the accession number is Q5R5V2.
TMPJ-00298	CD36 Protein, Human, Recombinant (aa 27-432, His) LGP85,Scavenger Receptor Class B Member 2,CD36,Lysosome<...	Human	HEK293 Cells
	Scavenger Receptor Class B Member 2 (SCARB2) is a type III multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far examined. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstructio...
TMPJ-01192	ELAPOR1 Protein, Human, Recombinant (His) ELAPOR1,Endosome-Lysosome Associated Apoptosis And ...	Human	HEK293 Cells
	Endosome/lysosome-associated apoptosis and autophagy regulator (ELAPOR1), also known as EIG121 protein, is a type I transmembrane protein induced by estrogen. The estrogen-induced gene 121 (EIG121) has been associated with breast and endometrial cancers,but its mechanism of action remains unknown.May protect cells from cell death by inducing cytosolic vacuolization and upregulating the autophagy pathway. That EIG121 is a good endometrial biomarker associated with a hyperestrogenic state and estr...
TMPJ-00837	LAMP1 Protein, Mouse, Recombinant (His) Lysosomal membrane glycoprotein A,CD107a,LAMP-1,CD107 antige...	Mouse	HEK293 Cells
	Lysosomal associated membrane protein 1 (LAMP1) is an approximately 120 kDa transmembrane glycoprotein that is a major protein component of lysosomal membranes. Mature mouse LAMP1 consists of a 346 amino acid (aa) intralumenal domain (ECD), a 24 aa transmembrane segment, and a 12 aa cytoplasmic tail. Its lumenal domain is organized into two heavily N-glycosylated regions separated by a Ser/Pro-rich linker that carries a minor amount of O-linked glycosylation. Within the lumenal domain, mouse LAM...
TMPK-01051	BLOC1S2 Protein, Human, Recombinant BLOS2,CEAP11,CEAP,BLOC-1 subunit 2	Human	E. coli
	BLOC1S2 (Biogenesis of lysosome-related organelles complex-1 subunit 2) protein is widely expressed in normal tissue as well as in malignant tumors with a tendency towards lower expression levels in certain subtypes of tumors. On the subcellular level, BLOC1S2 is expressed in an organellar-like pattern and co-localizes with mitochondria.
TMPH-01909	CPVL Protein, Human, Recombinant (His & SUMO) Carboxypeptidase, vitellogenic-like,VCP-like protein,hVLP,Vi...	Human	E. coli
	May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation. CPVL Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 67.9 kDa and the accession number is Q9H3G5.
TMPY-03598	EPDR1 Protein, Human, Recombinant (His) ependymin related 1,MERP1,UCC1,MERP-1,EPDR	Human	HEK293 Cells
	EPDR1 is a member of the ependymin family. EPDR1 is a type II transmembrane protein that is similar to two families of cell adhesion molecules, the protocadherins and ependymins. It may play a role in calcium-dependent cell adhesion. EPDR1 is glycosylated, and the orthologous mouse protein is localized to the lysosome. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8.
TMPH-02127	SNX16 Protein, Human, Recombinant (His) Sorting nexin-16,SNX16	Human	E. coli
	May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm.
TMPK-01161	LAMP5 Protein, Mouse, Recombinant (hFc) C20orf103,BADLAMP,dJ1119D9.3,LAMP-5,UNC-43,BAD-LAMP	Mouse	HEK293 Cells
	Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesicles. LAMP5 deficiency led to a larger intensity-dependent increase of wave I, II and V peak amplitude of auditory brainstem response. LAMP5 plays a pivotal role in sensorimotor processing in the brainstem and spinal cord. LAMP5 Protein, Mouse, Recombinant (hFc) is expressed in H...
TMPK-01234	LAMP5 Protein, Human, Recombinant (His) BAD-LAMP,BADLAMP,C20orf103,UNC-43,dJ1119D9.3,LAMP-5	Human	HEK293 Cells
	Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesicles. LAMP5 deficiency led to a larger intensity-dependent increase of wave I, II and V peak amplitude of auditory brainstem response. LAMP5 plays a pivotal role in sensorimotor processing in the brainstem and spinal cord. LAMP5 Protein, Human, Recombinant (His) is expressed in H...
TMPK-01069	TMEM106B Protein, Mouse, Recombinant (hFc) Transmembrane protein 106B,Tmem106b	Mouse	HEK293 Cells
	TMEM106B is a well-recognised risk factor for FTD caused by GRN mutation. Elegant experiments have suggested that increased risk for FTD is due to elevated levels of TMEM106B (Nicholson et al, 2013; Gallagher et al, 2017). Therefore, recent work has explored the therapeutic potential of reducing TMEM106B levels, with initial results looking encouraging, as crossing a Grn-deficient mouse to a Tmem106b knockout showed a rescue in FTD-related behavioural defects and specific aspects of lysosome dys...
TMPK-00659	LAMP5 Protein, Cynomolgus, Recombinant (His) C20orf103,BAD-LAMP,BADLAMP,LAMP-5,UNC-43,dJ1119D9.3	Cynomolgus	HEK293 Cells
	Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesicles. In the mouse forebrain, LAMP5 is expressed in a subpopulation of GABAergic neurons in the olfactory bulb and the striato-nigral system, where it is required for fine-tuning of GABAergic synaptic transmission. LAMP5 Protein, Cynomolgus, Recombinant (His) is expressed in HEK2...
TMPK-01233	LAMP5 Protein, Human, Recombinant (hFc) BADLAMP,C20orf103,LAMP-5,dJ1119D9.3,UNC-43,BAD-LAMP	Human	HEK293 Cells
	Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesicles. In the mouse forebrain, LAMP5 is expressed in a subpopulation of GABAergic neurons in the olfactory bulb and the striato-nigral system, where it is required for fine-tuning of GABAergic synaptic transmission. LAMP5 Protein, Human, Recombinant (hFc) is expressed in HEK293 ma...
TMPJ-00869	GLB1 Protein, Human, Recombinant (His) Lactase,Acid Beta-Galactosidase,Elastin Receptor 1,GLB1,Acid...	Human	HEK293 Cells
	β Galactosidase is a lysosomal β Galactosidase that hydrolyzes the terminal β Galactose from Ganglioside and Keratan sulfate. In lysosome, the mature β Galactosidase protein associates with Cathepsin A and Neuraminidase 1 to form the lysosomal multienzyme complex . An alternative splicing at the RNA level of β Galactosidase results a catalytically inactive β Galactosidase that plays an important role in vascular development. Defects of β-galactosidase (GLB1) are the cause of diseases like GM1-ga...
TMPY-02980	BLOC1S2 Protein, Human, Recombinant (GST) CEAP,CEAP11,BLOS2,biogenesis of lysosomal organelles complex...	Human	E. coli
	BLOC1S2, also known as BLOS2, belongs to the BLOC1S2 family. It is a component of BLOC-1 complex. The BLOC-1 complex is composed of BLOC1S1, BLOC1S2, BLOC1S3, DTNBP1, MUTED, PLDN, CNO/cappuccino and SNAPIN. The BLOC-1 complex is required for normal biogenesis of lysosome-related organelles, such as platelet dense granules and melanosomes. BLOC1S2 interacts directly with BLOC1S1, BLOC1S3, MUTED, CNO/cappuccino and SNAPIN. It may play a role in cell proliferation. It also plays a role in intracell...
TMPH-02282	Ubiquilin-1 Protein, Human, Recombinant (His & Myc) Ubiquilin-1,UBQLN1,Protein linking IAP with cytoskeleton 1	Human	E. coli
	Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its in...
TMPH-01692	MAPK3 Protein, Human, Recombinant (His) MAP kinase isoform p44,p44-ERK1,MAPK3,Extracellular signal-r...	Human	E. coli
	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, c...

重组蛋白

LIMPII/SR-B2 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00299

Species: Mouse

Expression System: HEK293 Cells

LAMP1 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00264

Species: Human

Expression System: HEK293 Cells

LIMPII/SR-B2 Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03324

Species: Rat

Expression System: E. coli

LAMP5 Protein, Pongo abelii, Recombinant (His & Myc)

Cat.No: TMPH-03146

Species: Pongo abelii

Expression System: E. coli

CD36 Protein, Human, Recombinant (aa 27-432, His)

Cat.No: TMPJ-00298

Species: Human

Expression System: HEK293 Cells

ELAPOR1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01192

Species: Human

Expression System: HEK293 Cells

LAMP1 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00837

Species: Mouse

Expression System: HEK293 Cells

BLOC1S2 Protein, Human, Recombinant

Cat.No: TMPK-01051

Species: Human

Expression System: E. coli

CPVL Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01909

Species: Human

Expression System: E. coli

EPDR1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03598

Species: Human

Expression System: HEK293 Cells

SNX16 Protein, Human, Recombinant (His)

Cat.No: TMPH-02127

Species: Human

Expression System: E. coli

LAMP5 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01161

Species: Mouse

Expression System: HEK293 Cells

LAMP5 Protein, Human, Recombinant (His)

Cat.No: TMPK-01234

Species: Human

Expression System: HEK293 Cells

TMEM106B Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01069

Species: Mouse

Expression System: HEK293 Cells

LAMP5 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00659

Species: Cynomolgus

Expression System: HEK293 Cells

LAMP5 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-01233

Species: Human

Expression System: HEK293 Cells

GLB1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00869

Species: Human

Expression System: HEK293 Cells

BLOC1S2 Protein, Human, Recombinant (GST)

Cat.No: TMPY-02980

Species: Human

Expression System: E. coli

Ubiquilin-1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02282

Species: Human

Expression System: E. coli

MAPK3 Protein, Human, Recombinant (His)

Cat.No: TMPH-01692

Species: Human

Expression System: E. coli

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼