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Search Results for " human igg2 "

Targets Recommended: EGFR

19

抑制剂 & 化合物

7

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T9927	Panitumumab	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Panitumumab 是一种重组全人源 IgG2 单克隆抗体，可与表皮生长因子(EGFR)结合，具有抗肿瘤活性。
T78243	Human IgG2 kappa, Isotype Control
	HumanIgG2kappa, Isotype Control为人源化单克隆抗体，作为human IgG2κ抗体的标准同型对照使用。
T76779	Brodalumab LP 0160,KHK-4827,AMG-827	IL Receptor	Immunology/Inflammation
	Brodalumab (AMG 827) 是一种人源靶向白介素 17 受体 (IL-17R) IgG2 的单克隆抗体，常作为免疫抑制剂来治疗银屑病和牛皮藓。
T77439	Glembatumumab	Others; ADC Antibody	Antibody-drug Conjugate/ADC Related; Others
	Glembatumumab 是一种靶向在人类乳腺癌和黑色素瘤中表达的 GPNMB 细胞外结构域的完全人类 IgG2 单克隆抗体。Glembatumumab 是 Glembatumumab vedotin 的裸抗，可用于研究抗体-活性分子偶联物（Glembatumumab vedotin ）。
T77491	Prezalumab AMG 557	Others	Others
	Prezalumab (AMG 557) 是一种针对 ICOSL 和 BAFF 的人源 IgG2 单克隆抗体。Prezalumab 可用于研究干燥综合征皮肤红斑狼疮、银屑病、系统性红斑狼疮关节炎和系统性红斑狼疮 (SLE)。
T9920	Evolocumab	Others	Others
	Evolocumab 是人源化单克隆抗体PCSK9的抑制剂。它与循环的 PCSK9 蛋白结合，使得PCSK9与 LDLR 结合受到抑制。它可用研究于高胆固醇血症以及动脉粥样硬化性心血管疾病的研究。
T76858	Ascrinvacumab PF-03446962	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	Ascrinvacumab (PF-03446962) 是一种针对 ALK-1 的高效人源化 IgG2 单克隆抗体。Ascrinvacumab 对人 ALK1 的 Kd 值为 7 nM。Ascrinvacumab 对 TGF-β 有抑制作用，可用于研究肝细胞癌 (HCC)。
T82367	Fulranumab
	Fulranumab为IgG2亚型针对神经生长因子（NGF）的单克隆抗体，适用于疼痛研究领域。
T76829	Tarextumab
	Tarextumab (OMP-59R5) 是一种抗 Notch2/3全人源 IgG2单克隆抗体。Tarextumab 具有抗肿瘤活性。
T76921	Befovacimab
	Befovacimab (BAY 1093884)，一种全人源单克隆IgG2抗体，特异性结合于组织因子通路抑制剂(TFPI)，适用于血友病A/B的研究。
T78304	Bapotulimab BAY-1905254
	Bapotulimab (BAY-1905254)为一种全人IgG2型单克隆抗体，专一性靶向免疫球蛋白样结构域含受体2(ILDR2)。该抗体展现出抗肿瘤及免疫抑制功能。
T76934	Brazikumab
	Brazikumab (AMG 139) 是一种人IgG2单克隆抗体，可选择性结合IL-23的 p19 亚基，对人IL-23的KD 值为 0.138 nM 的。Brazikumab 可用于克罗恩病的研究。
T76697	Panitumumab (anti-EGFR)
	Panitumumab (anti-EGFR) 是一种全人源IgG2抗EGFR 单克隆抗体，具有抗肿瘤活性。Panitumumab (anti-EGFR) 抑制肿瘤细胞增殖、存活和血管生成。Panitumumab (anti-EGFR) 可用于癌症研究，例如结肠癌。
T77450	Vantictumab OMP-18R5
	Vantictumab (OMP-18R5)为全人源IgG2单克隆抗体，针对FZD1/2/5/7/8受体抑制Wnt信号通路。该抗体适用于研究治疗转移性HER2阴性乳腺癌及转移性胰腺腺癌。
T78307	Catumaxomab
	Catumaxomab是一种IgG2类三功能抗体，由小鼠及大鼠抗体的重链与轻链构成，可与人类EpCAM及CD3受体结合。其Fc端能特异性结合FcγR1 (CD 64)、 FcγRIIA (CD 32a) 以及FcγRIII (CD 16)。该抗体主要应用于抗肿瘤治疗研究，尤其是针对上皮癌。
T77037	Insulin efsitora alfa
	Insulinefsitora alfa (LY-3209590) 为选择性胰岛素受体(IR)激动剂，该融合蛋白融合了人胰岛素受体(IR)激动剂与人免疫球蛋白G2(IgG2)的片段可结晶(Fc)结构域，分子量为64.1 kDa。Insulinefsitora alfa展现出良好的耐受性，并在糖尿病治疗中显示出潜在应用价值。
T76791	Seribantumab
	Seribantumab (MM 121) 是一种完全人 IgG2单克隆抗体，靶向 HER3。Seribantumab 阻断 ErbB 家族成员及其下游信号的激活。Seribantumab 在体内、外抑制乳腺癌、肺癌和卵巢癌患者源性癌症模型中神经调节蛋白 (NRG1) 融合依赖的肿瘤发生。
T77173	Eflepedocokin alfa
	Eflepedocokin alfa 是一种具有潜在细胞保护活性的重组融合蛋白。Eflepedocokin alfa 由人的IL-22与人的IgG2-Fc 结构域融合组成。Eflepedocokin alfa 可激活IL-22/IL-22R 介导的信号转导通路以及STAT3。Eflepedocokin alfa 在免疫反应和细菌感染、增强肠道屏障功能、肠道免疫和组织修复方面发挥作用。
T76974	Tafolecimab
	Tafolecimab (IBI-306) 是一种人源 lgG2 单克隆抗体，可特异性结合 PCSK-9并通过抑制 PCSK-9 介导的低密度脂蛋白受体的内吞作用降低 LDL-C 水平，进而增强对 LDL-C 的清除，导致 LDL-C 水平降低。Tafolecimab 可用于高胆固醇血症的研究。

化合物

Cat.No: T9927

Target: EGFR

Human IgG2 kappa, Isotype Control

Cat.No: T78243

Cat.No: T76779

Synonym: LP 0160,KHK-4827,AMG-827

Target: IL Receptor

Cat.No: T77439

Target: Others, ADC Antibody

Cat.No: T77491

Synonym: AMG 557

Target: Others

Cat.No: T9920

Target: Others

Cat.No: T76858

Synonym: PF-03446962

Target: ALK, TGF-beta/Smad

Cat.No: T82367

Cat.No: T76829

Cat.No: T76921

Cat.No: T78304

Synonym: BAY-1905254

Cat.No: T76934

Panitumumab (anti-EGFR)

Cat.No: T76697

Cat.No: T77450

Synonym: OMP-18R5

Cat.No: T78307

Insulin efsitora alfa

Cat.No: T77037

Cat.No: T76791

Eflepedocokin alfa

Cat.No: T77173

Cat.No: T76974

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02692	IgG2 Protein, Human, Recombinant (S257A) Immunoglobulin heavy constant gamma 2,IgG<...	Human	HEK293 Cells
	IgG2 Protein, Human, Recombinant (S257A) is expressed in HEK293 mammalian cells. The predicted molecular weight is 25 kDa and the accession number is P01859.
TMPY-00105	Recombinant Protein G		E. coli
	Protein G is a bacterial cell wall protein expressed at the cell surface of certain group C and group G Streptococcal strains. It has affinity for both Fab- and Fc-fragments of human IgG by independent and separate binding sites. Binding to the Fc region of immunoglobulins from several species by a non-immune mechanism exhibits great affinity for almost all mammalian immunoglobulin G (IgG) classes, including all human IgG subclasses (IgG1, IgG2, IgG3 and IgG4) and also rabbit, mouse, and goat Ig...
TMPY-04964	Recombinant Protein A, HRP conjugate
	Protein A is surface protein originally found in the cell wall of the bacteria Staphylococcusaureus. It is encoded by the spa gene and its regulation is controlled by DNA topology, cellular osmolarity, and a two component system called ArlS-ArlR. Protein A binds the Fc region of various mammalian IgG subclasses including: Human IgG1, IgG2, IgG3 (weakly), IgG4 Mouse IgG1 (weakly), IgG2a, IgG2b, IgG3 SPA also binds IgG from monkey, rabbit, pig, guinea pig, dog, rat and cat. It also weakly binds to...
TMPK-01534	Chimeric HLA-A02:01 (mα3) &B2M&LMP2 (CLGGLLTMV) Monomer Protein, Human*&Mouse, MHC (His & Avi) RING12,PSMB9,Proteasome chain 7,RMF,LMP-2,...	Human & Mouse	HEK293 Cells
	The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that selectively inhibit the major catalytic subunit, LMP2, of the immunoproteasome,LMP2-rich cancer cells compared to LMP2-deficient cancer cells are more sensitive to growth inhibition by the LMP2-specific inhibitor, implicating an important role of LMP2 in regulating cell growth of ma...
TMPK-01523	Chimeric HLA-A02:01 (mα3) &B2M&WT-1 (RMFPNAPYL) Monomer Protein, Human*&Mouse, MHC (His & Avi) WAGR,WT33,AWT1,GUD,RMF,WT1,WIT-2,MHC,NPHS4GUD	Human & Mouse	HEK293 Cells
	The WT1 protein plays a role in cell growth, the process by which cells mature to perform specific functions (differentiation), and the self-destruction of cells (apoptosis). WT1 is differentially expressed in serous, endometrioid, clear cell, and mucinous carcinomas of the peritoneum, fallopian tube, ovary, and endometrium.The Human HLA-A0201 WT-1 (RMFPNAPYL) complex Protein is a complex of HLA-A0201 of the MHC Class I, B2M and RMFPNAPYL peptide of the WT-1.
TMPK-01535	Chimeric HLA-A02:01 (mα3) &B2M&LMP2 (CLGGLLTMV) Tetramer Protein, Human*&Mouse, MHC (His & Avi) Macropain chain 7,LMP2,Proteasome chain 7,RING1...	Human & Mouse	HEK293 Cells
	The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that selectively inhibit the major catalytic subunit, LMP2, of the immunoproteasome,LMP2-rich cancer cells compared to LMP2-deficient cancer cells are more sensitive to growth inhibition by the LMP2-specific inhibitor, implicating an important role of LMP2 in regulating cell growth of ma...
TMPK-01522	Chimeric HLA-A02:01 (mα3) &B2M&WT-1 (RMFPNAPYL) Tetramer Protein, Human*&Mouse, MHC (His & Avi) RMF,WT33,WIT-2,MHC,WAGR,AWT1,GUD,WT1,NPHS4GUD	Human & Mouse	HEK293 Cells
	The WT1 protein plays a role in cell growth, the process by which cells mature to perform specific functions (differentiation), and the self-destruction of cells (apoptosis). WT1 is differentially expressed in serous, endometrioid, clear cell, and mucinous carcinomas of the peritoneum, fallopian tube, ovary, and endometrium.The Human HLA-A0201 WT-1 (RMFPNAPYL) complex Protein is a complex of HLA-A0201 of the MHC Class I, B2M and RMFPNAPYL peptide of the WT-1.

重组蛋白

IgG2 Protein, Human, Recombinant (S257A)

Cat.No: TMPY-02692

Species: Human

Expression System: HEK293 Cells

Recombinant Protein G

Cat.No: TMPY-00105

Expression System: E. coli

Recombinant Protein A, HRP conjugate

Cat.No: TMPY-04964

Expression System:

Chimeric HLA-A*02:01 (mα3) &B2M&LMP2 (CLGGLLTMV) Monomer Protein, Human&Mouse, MHC (His & Avi)

Cat.No: TMPK-01534

Species: Human & Mouse

Expression System: HEK293 Cells

Chimeric HLA-A*02:01 (mα3) &B2M&WT-1 (RMFPNAPYL) Monomer Protein, Human&Mouse, MHC (His & Avi)

Cat.No: TMPK-01523

Species: Human & Mouse

Expression System: HEK293 Cells

Chimeric HLA-A*02:01 (mα3) &B2M&LMP2 (CLGGLLTMV) Tetramer Protein, Human&Mouse, MHC (His & Avi)

Cat.No: TMPK-01535

Species: Human & Mouse

Expression System: HEK293 Cells

Chimeric HLA-A*02:01 (mα3) &B2M&WT-1 (RMFPNAPYL) Tetramer Protein, Human&Mouse, MHC (His & Avi)

Cat.No: TMPK-01522

Species: Human & Mouse

Expression System: HEK293 Cells

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