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Search Results for " homodimers "

Targets Recommended: Others RAR/RXR

5

抑制剂 & 化合物

1

化合物库

18

重组蛋白

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Cat. No.	Product Name
L3800	NF-κB 通路分子库		729 compounds
	729 个 NF-κB 信号通路相关的小分子化合物的特有集合，用于高通量、高内涵筛选；

化合物库

NF-κB 通路分子库

Cat.No: L3800

Compounds: 729

Cat. No.	Product Name	Target	Signaling Pathways
T23383	SR11237 SR 11237	Others; RAR/RXR	Metabolism; Others
	SR11237 是一种泛视黄醇 X 受体 (RXR) 激动剂。 SR11237 导致 RXR/RXR 同源二聚体形成并反式激活包含 RXR 反应元件的报告基因。
T26859	BMS-8	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	BMS-8 抑制PD-1/PD-L1相互作用(IC50:7.2 μM)。它能够直接与 PD-L1 结合，促使形成 PD-L1 同源二聚体，进而阻断 PD-L1 与 PD-1 的相互作用。
T78870	TWIK-1/TREK-1-IN-3	Potassium Channel	Membrane transporter/Ion channel
	TWIK-1/TREK-1-IN-3 是一种具有选择性和有效性的钾通道 TREK-1 抑制剂，对含有双孔域钾(K2p)通道的TREK-1同二聚体和TWIK-1/TREK-1异二聚体有抑制作用。TWIK-1/TREK-1-IN-3 具有抗抑郁活性，可用于研究抑郁症。
T32107	HX-603 HX 603	Others	Others
	HX-603 is a selectivity agonist of RXR that inhibits the activation of RAR-RXR heterodimers as well as RXR homodimers.
T78868	TWIK-1/TREK-1-IN-1	Potassium Channel	Membrane transporter/Ion channel
	TWIK-1/TREK-1-IN-1 (compound 2a) 是一种针对 TWIK 相关钾通道 (Potassium Channel) TREK-1 的抑制剂，有效抑制 TREK-1 的双孔域钾 (K2p) 通道，阻止其二聚化形成 TREK-1 同二聚体和 TWIK-1/TREK-1 异二聚体。作为抗抑郁治疗的潜在靶点，TWIK-1/TREK-1-IN-3 对 TREK-1 同二聚体和 TWIK-1/TREK-1 异二聚体表现出相当的选择性，IC50s 分别是 9.36 μM 和 14.6 μM，显示出抗抑郁样活性。

化合物

Cat.No: T23383

Synonym: SR 11237

Target: Others, RAR/RXR

Cat.No: T26859

Target: PD-1/PD-L1

TWIK-1/TREK-1-IN-3

Cat.No: T78870

Target: Potassium Channel

Cat.No: T32107

Synonym: HX 603

Target: Others

TWIK-1/TREK-1-IN-1

Cat.No: T78868

Target: Potassium Channel

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01471	Activin A Protein, Human, Mouse, Rat, Cynomolgus, Rhesus, Recombinant Activin A,INHBA,Inhibin beta A chain,Inhibin β A chain	Human/Mouse/Rat	HEK293 Cells
	Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell developm...
TMPY-03407	NQO1 Protein, Human, Recombinant (His) NAD(P)H dehydrogenase, quinone 1,NMORI,DIA4,QR1,NMOR1,DTD,DH...	Human	E. coli
	NQO1 gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. NQO1 forms homodimers and reduces quinones to hydroquinones. NQO1's enzymatic activity prevents the one-electron reduction of quinones that results in the production of radical species. Mutations in the NQO1 gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered ex...
TMPY-02888	MAX Protein, Human, Recombinant (His & GST) MYC associated factor X,bHLHd4	Human	Baculovirus Insect Cells
	MYC associated factor X contains 1 basic helix-loop-helix (bHLH) domain and belongs to the MAX family. It is highly expressed in the brain, heart, and lung while lower levels are seen in the liver, kidney, and skeletal muscle. MYC associated factor X can form homodimers and heterodimers with other family members, which include Mad, Mxi1, and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation, and apoptosis. The homodimers and heterodimers compete for a common DNA target...
TMPJ-00046	IL-17F Protein, Human, Recombinant IL17F,白介素,IL-17F,Interleukin-17F,白细胞介素,Cytokine ML-1	Human	E. coli
	Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Today, IL-17 represents a family of structurally related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17F also regulates cartilage mat...
TMPJ-00931	Serpin A4 Protein, Human, Recombinant (His) Kallistatin,Peptidase Inhibitor 4,KST,Kallikrein Inhibitor,S...	Human	HEK293 Cells
	Serpin Peptidase Inhibitor, Clade A (α-1 Antiproteinase, Antitrypsin), Member 4 (Serpin A4) is a member of the Serpin family. Serpin A4 exists as a monomer and some homodimers. Serpin A4 is expressed by the liver and secreted in plasma. Serpin A4 is a regulator of vascular homeostasis capable of controlling a wide spectrum of biological actions in the cardiovascular and renal systems. It can inhibit intracellular reactive oxygen species formation in cultured cardiac and renal cells. In addition,...
TMPY-03974	Bim Protein, Human, Recombinant (His) BAM,BCL2-like 11 (apoptosis facilitator),BIM,BOD	Human	E. coli
	BCL2L11, also known as Bim, belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL2L11 contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. BCL2L11 gene functions as an essential initiator of apoptosis in thymoc...
TMPY-03434	BMF Protein, Human, Recombinant (His) Bcl2 modifying factor	Human	E. coli
	BMF(Bcl2 modifying factor) belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BMF contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. BMF is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular d...
TMPJ-00363	IL-12RB1 Protein, Human, Recombinant (hFc) IL-12R-β1,IL-12R-BETA1,IL-12 receptor subunit beta-1,IL12RB,...	Human	HEK293 Cells
	Interleukin12 receptor subunit beta 1 (IL12RB1) is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. IL12RB1 can spontaneously form homodimers and -oligomers, which are able to bind IL12 with only low affinity. IL12 high affinity receptor complex is composed of two subunits designated IL12RB1 and IL12RB2. While IL12RB1 interacts with the IL-12p40 subunit, IL-12p35 is mainly connecting with IL12RB2. This receptor chain is also responsible for transmitting the IL...
TMPJ-00397	IL-17RA Protein, Human, Recombinant (His & Avi), Biotinylated CD217,IL17RA,interleukin 17 receptor A,IL17Rinterleukin-17 r...	Human	HEK293 Cells
	CD217, also known as Interleukin-17 receptor A, is a T cell expressed pleotropic cytokine with 866 amino acids in length. CD217 functions as receptors for IL17A and IL17F, it binds to IL17A with higher affinity than to IL17F and binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC. It also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC. The activation of IL17RA would lead to induction of expression of inflammatory chemokines...
TMPJ-01089	TFF1 Protein, Mouse, Recombinant (His) Bcei,Protein pS2,Ps2,Trefoil factor 1,Tff1	Mouse	HEK293 Cells
	Trefoil Factor 1 (TFF1) belongs to the three structurally related secreted proteins that contain trefoil domains.TFF1 is an approximately peptide that has an important effect in epithelial regeneration and wound healing.It originates from musculus and highly expressed by goblet cells of the gastric and intestinal mucosa and by conjunctival goblet cells. TFF1 is a copper-binding protein that can form disulfide-linked homodimers, associate into disulfide-linked complexes with Gastrokine 2, and fo...
TMPJ-00058	BTC Protein, Mouse, Recombinant (His) βcellulin,isoform CRA_a,Btc,Betacellulin,mCG_12529	Mouse	E. coli
	Mouse Betacellulin is a single type I membrane protein which belongs to the EGF family of cytokines. EGF family has many members including EGF, TGF-a, Amphiregulin, HB-EGF, Epiregulin, Tomoregulin and the Neuregulins. Betacellulin is characterised by a six-cysteine consensus motif that forms three intra-molecular disulfide bonds crucial for binding the ErbB receptor family. Betacellulin is expressed in several tissues and tumor cells including kidney, uterus, liver, pancreas and small intestine....
TMPJ-00716	Cerberus 1/CER1 Protein, Human, Recombinant (HEK293, His) DAN Domain Family Member 4,Cerberus,Cerberus-Related Protein...	Human	HEK293 Cells
	Cerberus 1 is a secreted glycoprotein that forms disulfide-linked homodimers. It is a cytokine member of the DAN domain family of BMP antagonists that includes DAN (DAND1), Gremlin/Drm (DAND2), PRDC (Protein Related to Dan and Cerberus, DAND3), and COCO/Dante (DAND5). DAN family members contain a cysteine knot domain that is homologous to that found in other TGF-beta superfamily ligands. At the onset of gastrulation, Cerberus 1 is transiently expressed in anterior endodermal structures in respon...
TMPY-00004	CD28 Protein, Rat, Recombinant (hFc) CD28 molecule	Rat	HEK293 Cells
	CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. Mouse CD28 is constitutively expressed on the surface of all murine T cells and on developing thymocytes as disulfide-linked homodimers or as monomers. CD28 can binds the B7-1 and B7-2 ligand, and together perform important functions in the T and B cell r...
TMPY-02797	TXNL4A Protein, Human, Recombinant (His) U5-15kD,thioredoxin-like 4A,DIB1,SNRNP15,TXNL4,BMKS,DIM1	Human	E. coli
	DIM1, also known as TXNL4A, is a member of the Dim protein family. The Dim protein family is composed of two classes, DIM1and Dim2, which share a common thioredoxin-like fold. They were originally identified for their role in cell cycle progression and have been found to interact with Prp6, an essential component of the spliceosome, which forms the bridge of U4/U6.U5-tri-snRNP. Despite their biological and structural similarities, DIM1 and Dim2 proteins differ in many aspects. DIM1 bears distinc...
TMPY-01618	GLO1 Protein, Mouse, Recombinant (His) glyoxalase I,Glo-1r,GLY1,Glo1-r,2510049H23Rik,Glo1-s,AW55064...	Mouse	E. coli
	Lactoylglutathione lyase, also known as Methylglyoxalase, Aldoketomutase, Glyoxalase I, Ketone-aldehyde mutase, S-D-lactoylglutathione methylglyoxal lyase and GLO1, is a member of the glyoxalase I family. GLO1 / Glyoxalase I is a ubiquitous cellular defense enzyme involved in the detoxification of methylglyoxal, a cytotoxic byproduct of glycolysis. Accumulative evidence suggests an important role of GLO1 expression in protection against methylglyoxal-dependent protein adduction and cellul...
TMPJ-00385	CDH6 Protein, Human, Recombinant (hFc) K-Cadherin,Cadherin-6,CDH6,Kidney Cadherin	Human	HEK293 Cells
	Cadherin-6 (CDH6) is a type-II classic cadherin cell-cell adhesion molecules, which are expressed in graded or areal patterns, as well as layer-specific patterns, in the cortical plate. Human Cadherin-6 is synthesized as a 790 aa type I transmembrane glycoprotein that contains a 18 aa signal peptide, a 35 aa propeptide, a 562 aa extracellular region, a 21 aa transmembrane segment, and a 154 aa cytoplasmic domain. There are five cadherin domains of approximately 110 aa each in the extracellular r...
TMPY-02723	TXNL4B Protein, Human, Recombinant (His) DLP,Dim2,thioredoxin-like 4B	Human	E. coli
	Dim2, also known as TXNL4B, is a member of the DIM1 family. The Dim protein family is composed of two classes, Dim1and Dim2, which share a common thioredoxin-like fold. They were originally identified for their role in cell cycle progression and have been found to interact with Prp6, an essential component of the spliceosome, which forms the bridge of U4/U6.U5-tri-snRNP. Despite their biological and structural similarities, Dim1 and Dim2 proteins differ in many aspects. Dim1 bears distinctive st...
TMPY-01052	R-Cadherin/CDH4 Protein, Human, Recombinant (His) R-CAD,cadherin 4, type 1, R-cadherin (retinal),RCAD,CAD4	Human	HEK293 Cells
	The cadherin superfamily is a large family that engage in both homo- and heterotypic, calcium-dependent, cell-cell adhesion events, and can be divided into at least four subfamilies based on the extracellular (EC) regions and cytoplasmic domains, that is: classical cadherins, desmosomal cadherins, protocadherins, and cadherin-like molecules. Human cadherin 4, type 1, R-cadherin (retinal), also known as CDH4, CAD4 and RCAD, is a classical cadherin from the cadherin superfamily. It is a calcium-de...

重组蛋白

Activin A Protein, Human, Mouse, Rat, Cynomolgus, Rhesus, Recombinant

Cat.No: TMPJ-01471

Species: Human/Mouse/Rat

Expression System: HEK293 Cells

NQO1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03407

Species: Human

Expression System: E. coli

MAX Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02888

Species: Human

Expression System: Baculovirus Insect Cells

IL-17F Protein, Human, Recombinant

Cat.No: TMPJ-00046

Species: Human

Expression System: E. coli

Serpin A4 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00931

Species: Human

Expression System: HEK293 Cells

Bim Protein, Human, Recombinant (His)

Cat.No: TMPY-03974

Species: Human

Expression System: E. coli

BMF Protein, Human, Recombinant (His)

Cat.No: TMPY-03434

Species: Human

Expression System: E. coli

IL-12RB1 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00363

Species: Human

Expression System: HEK293 Cells

IL-17RA Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPJ-00397

Species: Human

Expression System: HEK293 Cells

TFF1 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01089

Species: Mouse

Expression System: HEK293 Cells

BTC Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00058

Species: Mouse

Expression System: E. coli

Cerberus 1/CER1 Protein, Human, Recombinant (HEK293, His)

Cat.No: TMPJ-00716

Species: Human

Expression System: HEK293 Cells

CD28 Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-00004

Species: Rat

Expression System: HEK293 Cells

TXNL4A Protein, Human, Recombinant (His)

Cat.No: TMPY-02797

Species: Human

Expression System: E. coli

GLO1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01618

Species: Mouse

Expression System: E. coli

CDH6 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00385

Species: Human

Expression System: HEK293 Cells

TXNL4B Protein, Human, Recombinant (His)

Cat.No: TMPY-02723

Species: Human

Expression System: E. coli

R-Cadherin/CDH4 Protein, Human, Recombinant (His)

Cat.No: TMPY-01052

Species: Human

Expression System: HEK293 Cells

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