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Search Results for " histone "
Targets Recommended: Histone Acetyltransferase Histone Demethylase Histone Methyltransferase Others

502

抑制剂 & 化合物

30

天然产物

5

化合物库

98

重组蛋白

5

同位素标记化合物

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Cat. No. Product Name
L3500 组蛋白修饰化合物库

469 compounds
469 个组蛋白修饰相关的小分子化合物的特有集合,用于高通量、高内涵筛选;
L3510 甲基化化合物库

128 compounds
128 种甲基化相关的化合物,可以用于高通量和高内涵筛选;
L8300 染色质修饰分子库

250 compounds
250 种染色质化学修饰相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选;
L1200 表观遗传库

953 compounds
953 种表观遗传学研究相关的生物活性小分子的特有集合,用于表观遗传学研究及其相关的检测和高通量、高内涵筛选;
L8000 干细胞分化化合物库

1197 compounds
1197 种干细胞分化信号通路相关的生物活性小分子化合物的特有集合,可用于高通量、高内涵筛选;

化合物库

组蛋白修饰化合物库
Cat.No: L3500
Compounds: 469
甲基化化合物库
Cat.No: L3510
Compounds: 128
染色质修饰分子库
Cat.No: L8300
Compounds: 250
表观遗传库
Cat.No: L1200
Compounds: 953
干细胞分化化合物库
Cat.No: L8000
Compounds: 1197
Cat. No. Product Name Target Signaling Pathways
T38766L Histone H3 (1-35) acetate

Others Others
Histone H3 (1-35) acetate 是组蛋白 H3 的 35 个残基肽。组蛋白 H3 是一种重要的蛋白质,在基因的动态和长期调控中发挥作用。
T11563 Histone Acetyltransferase Inhibitor II

Epigenetic Reader Domain; Histone Acetyltransferase Chromatin/Epigenetic
Histone Acetyltransferase Inhibitor II 是一种选择性的细胞渗透性 p300 组蛋白乙酰转移酶抑制剂,IC50值为 5 µM。它在哺乳动物细胞中具有抗乙酰化酶活性,可用于癌症研究。
T2157 M344

MS 344,Histone Deacetylase Inhibitor III

HDAC Chromatin/Epigenetic; DNA Damage/DNA Repair
M344 (Histone Deacetylase Inhibitor III) 是一种组蛋白去乙酰化酶抑制剂,IC50为 100 nM。
T41019 Histone H1-derived Peptide

Histone H1-derived Peptide

Histone H1-derived peptide is a phosphopeptide with peptide substrates that consist of a sequence aligned with the optimal recognition motif for cyclin-dependent kinases (CDKs).
T40993 Histone H3 (1-21)

Histone H3 (1-21)

Histone H3 (1-21) is a truncated form of the Histone H3 protein consisting of amino acids 1 to 21. It serves as a common substrate for methyltransferase assays targeting Histone 3 at lysine 4 and lysine 9, as well as for acetyltransferase assays targeting Histone 3 at lysine 9 and lysine 14.
T38766 Histone H3 (1-35)

Histone H3 (1-35)

Histone H3 (1-35) is a 35-residue peptide derived from histone H3, which is a key member of the five main histones participating in the formation of chromatin within eukaryotic cells.
T38785 Histone H3 (21-44)

Histone H3 (21-44)

Histone H3 (21-44), derived from a sequence of 21-44 amino acids of histone H3, is commonly employed as a substrate, particularly for protein arginine methyltransferase assays, where methylation activity is being examined.
T39580 Histone H3 (23-34)

Histone H3 (23-34)

Histone H3 (23-34) is a peptide consisting of amino acid residues 23 to 34 of the histone H3 protein. This peptide specifically includes lysine residues at positions 23 and 27, which can undergo methylation and acetylation modifications.
T40407 Histone H3 (5-23)

Histone H3 (5-23)

Histone H3 (5-23), a derivative of histone H3 consisting of amino acids 5-23, serves as a substrate for histone acetyltransferase (HAT) assays.
T38784 Histone H3 (1-25), amide

Histone H3 (1-25), amide

Histone H3 (1-25), amide is a N-terminal peptide fragment of histone H3 that serves as a substrate for histone methyltransferases (HMTs). It can be utilized to identify the substrate for HMTs. Compared to histone H3 (15-39) and full-length histone H3, Histone H3 (1-25), amide proves to be more efficient as a substrate for HMT G9a.
T41061 Histone H3 (116-136), C116-136

Histone H3 (116-136), C116-136

Histone H3 (116-136), C116-136 is a peptide consisting of amino acids 116 to 136, which spans the C-terminus of histone H3.
T3206 NKL 22

Histone Deacetylase Inhibitor IV,PAOA

HDAC Chromatin/Epigenetic; DNA Damage/DNA Repair
NKL 22 (Histone Deacetylase Inhibitor IV) 是一种有效的选择性组蛋白脱乙酰基酶(HDAC) 抑制剂,对 HDAC2/4/5/7/8 具有选择性,抑制HDAC1和HDAC3的IC50值分别为 199 和 69 nM。它可改善亨廷顿氏病转基因小鼠的疾病表型和转录异常。
T36980 Histone H3K27Me1 (23-34) (trifluoroacetate salt)

Histone H3K27Me1 (23-34) (trifluoroacetate salt)

Others Others
Histone H3K27Me1 (23-34) is a peptide fragment of histone H3 that corresponds to amino acid residues 24-35 of the human histone H3.1 and H3.2 sequences. Monomethylation of histone H3 at lysine 27 is associated with actively transcribed genes and positively correlates with H3K36 trimethylation. Levels of H3K27Me1 are increased in tumor tissue isolated from patients with metastatic hormone-na ve and castration-resistant prostate cancer. Histone H3K27Me1 (23-34) has been used in epitope mapping of ...
T77560 Histone acetyltransferase p300 Inhibitor 4c

Carbonic Anhydrase; AChE Metabolism; Neuroscience
Histone acetyltransferase p300 Inhibitor 4c 是2-氨基噻唑衍生物,Histone acetyltransferase p300 Inhibitor 4c 对 hCA I 、hCA II、AChE 和 BChE 具有抑制作用,Ki 值为 0.008 ± 0.001 、 0.124 ± 0.017、0.129 ± 0.030 和 0.083 ± 0.041 μM。
T36576 Histone H3 (21-44)-GK-biotin (trifluoroacetate salt)

Histone H3 (21-44)-GK-biotin (trifluoroacetate salt)

Others Others
Histone H3 (21-44)-GK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.1 and 3.2 sequences and is biotinylated via a C-terminal GK linker. Histone H3 (21-44) contains a lysine residue at position 23 that is subject to acetylation, an arginine at position 26 subject to methylation, and a serine at position 28 subject to phosphorylation, as well as lysine residues at positions 27 and 36 that are subject to methylation and acetylation....
T36979 Histone H3 (21-44)-GK-biotin amide (trifluoroacetate salt)

Histone H3 (21-44)-GK-biotin amide (trifluoroacetate salt)

Others Others
Histone H3 (21-44)-GK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.3 sequence and is biotinylated via a C-terminal GK linker. Unlike histone H3.1 and H3.2, the histone H3.3 variant contains a serine residue at position 31 that is phosphorylated during late prometaphase and metaphase of mitosis. Histone H3 (21-44) also contains lysine residues at positions 23, 27, and 36 that are subject to methylation and acetylation, all of whi...
T36095 Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt)

Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt)

Others Others
Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt) 可用于生命科学领域的相关研究,其产品编号为 T36095。
T36577 K-Biotin-W-Histone H2B (108-125) (trifluoroacetate salt)

K-Biotin-W-Histone H2B (108-125) (trifluoroacetate salt)

Others Others
Histone H2B (108-125) is a peptide fragment of histone H2B that corresponds to amino acid residues 109-126 of the human histone H2B sequence. It contains an N-terminal biotinylated lysine followed by a tryptophan linker. Histone H2B can be modified by addition of an O-linked N-acetylglucosamine (GlcNAc) moiety to the serine residue at position 112, which promotes monoubiquitination of the lysine at position 120.1 Both of these modifications are associated with active transcription. Histone H2B a...
T3193 Pimelic diphenylamide 106

Histone Deacetylase Inhibitor VII,TC-H 106,RGFA-8

HDAC Chromatin/Epigenetic; DNA Damage/DNA Repair
Pimelic diphenylamide 106 (RGFA-8) 是一种缓慢和紧密结合的I 类HDAC 抑制剂,对HDAC1、 2和3的IC50值分别150、760和370 nM。
TP1536 Histone H4 (2-21)

Histone H4 (2-21) is a pivotal core histone involved in the process of chromatinization specific to the genomes of herpes simplex virus 1 (HSV-1).
TP2257 Histone-H2A-(107-122)-Ac-OH

Others Others
Histone-H2A-(107-122)-Ac-OH is a peptide with the sequence Ac-Gly-Val-Leu-Pro-Asn-Ile-Gln-Ala-Val-Leu-Leu-Pro-Lys-Lys-Thr-Glu-OH, MW= 1762.1. Histone H2A is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells.
T64592 Histone H3 Antibody #9715R

Others Others
Histone H3 Antibody #9715R 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T64592。
T16435 PBIT

Histone Demethylase; Histone Methyltransferase Chromatin/Epigenetic
PBIT 是一种特异性 Jumonji/AT 富集互作结构域 1 抑制剂,抑制JARID1A 和JARID1C,IC50分别为 6 和 4.9 μM。它抑制JARID1B(KDM5B 或PLU1) 组蛋白去甲基化酶,IC50值约为 3 μM。
T11807 L002

Others; Histone Acetyltransferase; STAT Chromatin/Epigenetic; JAK/STAT signaling; Others; Stem Cells
L002 是一种细胞可渗透的,可逆特定性乙酰转移酶 p300(KAT3B)抑制剂,IC50为 1.98 μM。 它结合乙酰辅酶 A 口袋并竞争性抑制 FATp300 催化结构域,阻断组蛋白乙酰化和 p53 乙酰化,且抑制 STAT3 激活,有用于高血压引起的心脏肥大和纤维化的研究潜力。
T9243 PFI-90

Histone Demethylase; Others Chromatin/Epigenetic; Others
PFI-90 是组蛋白去甲基化酶 (KDM3B) 的选择性抑制剂,可抑制 PAX3-FOXO1 的作用。它具有抗肿瘤活性的潜力,可诱导细胞凋亡和成肌分化,导致细胞死亡增加。
T8344 CPTH2

Apoptosis; Histone Acetyltransferase Apoptosis; Chromatin/Epigenetic
CPTH2 是一种组蛋白乙酰基转移酶抑制剂。它选择性地抑制Gcn5对组蛋白 H3 的乙酰化,通过抑制乙酰转移酶p300 (KAT3B)诱导凋亡并降低透明细胞肾癌细胞系的侵袭性。
T3499 Remodelin

Histone Acetyltransferase Chromatin/Epigenetic
Remodelin 是一种特异性有效的乙酰转移酶蛋白 NAT10 抑制剂。
T5347 CXD101

CXD-101

HDAC Chromatin/Epigenetic; DNA Damage/DNA Repair
CXD101 是一种选择性和具有口服活性的 I 类HDAC 抑制剂,有抗肿瘤活性,对HDAC1、HDAC2和HDAC3的IC50分别为 63、570 和 550 nM。
T6327 Tubacin

Virus Protease; HDAC Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology
Tubacin 是一种高效、选择性、可逆、可渗透细胞的 HDAC6 抑制剂,IC50 为 4 nM,选择性是 HDAC1 的约 350 倍。
T76381 H1-7 (histone H1 phosphorylation site), PKA Substrate

H1-7 (histone H1 phosphorylation site),PKASubstrate 是一种合成多肽,可作为PKA 底物。
T1819 Nexturastat A

HDAC Chromatin/Epigenetic; DNA Damage/DNA Repair
Nexturastat A 是一种有效且特异性的 HDAC6 抑制剂,IC50: 5 nM。它的选择性是其他 HDAC 的 190 倍以上。
T7664 Pyroxamide

Apoptosis; HDAC Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
Pyroxamide 是一种组蛋白脱乙酰基酶 1 抑制剂,IC50为 100 nM。 它可以诱导白血病细胞凋亡和细胞周期停滞。
T8778 TTK21

Epigenetic Reader Domain Chromatin/Epigenetic
TTK21 是 CBP/p300 组蛋白乙酰转移酶活性的激活剂,与葡萄糖基碳纳米球结合时,可通过血脑屏障,对成人大脑神经发生和长期记忆功能有益。
T64611 Acetyl-Histone H3 (Lys9) (C5B11) Rabbit mAb #9649R

Others Others
Acetyl-Histone H3 (Lys9) (C5B11) Rabbit mAb #9649R 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T64611。
T6055 Quisinostat

奎诺司他,JNJ-26481585

Apoptosis; HDAC; Autophagy Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair
Quisinostat (JNJ-26481585) 是一种高效的,具有口服活性的 pan-HDAC 抑制剂,对 HDAC1、HDAC2、HDAC4、HDAC10、HDAC11 作用的 IC50值范围为 0.11-0.64 nM。它在成神经细胞瘤中能诱导自噬,具有广泛的抗肿瘤活性。
T5830 SKLB-23bb

HDAC Chromatin/Epigenetic; DNA Damage/DNA Repair
SKLB-23bb 是一种口服生物可利用的 HDAC6 选择性抑制剂,还具有微管破坏能力,IC50为 17 nM。它比HDAC1和HDAC8选择性分别高 25 倍和 200 倍,IC50为 422 和 3398 nM。
T9745 Elevenostat

HDAC Chromatin/Epigenetic; DNA Damage/DNA Repair
Elevenostat 是有效的HDAC11选择性抑制剂 (IC50=0.235 µM)。Elevenostat 具有抗多发性骨髓瘤的活性。
T12098 MOZ-IN-2

Histone Acetyltransferase Chromatin/Epigenetic
MOZ-IN-2 是一种MOZ,属于组蛋白乙酰转移酶的抑制剂,IC50值为 125 nM。
T16129 MPI_5a

HDAC Chromatin/Epigenetic; DNA Damage/DNA Repair
MPI_5a 是高效的 HDAC6选择性抑制剂,IC50=36 nM,对其他 HDAC 酶几乎无抑制作用。MPI_5a 抑制细胞内酰基微管蛋白积累, IC50为 210 nM。
T5322 BCI-121

Histone Methyltransferase Chromatin/Epigenetic
BCI-121是一种底物竞争性 SMYD3 抑制剂,可抑制癌细胞的增殖。
T3084 SGC707

Histone Methyltransferase Chromatin/Epigenetic
SGC707 是 PRMT3化学探针,是一种有效的、选择性的、细胞活性的 PRMT3 变构抑制剂,IC50值为 31 nM。
T1775 GSK503

Histone Methyltransferase Chromatin/Epigenetic
GSK503是一种高效特异性EZH2甲基转移酶抑制剂,Ki 值为3到27 nM,具有潜在的抗肿瘤活性。
T4021 UNC3866

Histone Methyltransferase Chromatin/Epigenetic
UNC3866 CBX7-H3 相互作用的有效拮抗剂,IC50为 66±1.2 nM。
T1905 EPZ005687

Histone Methyltransferase Chromatin/Epigenetic
EPZ005687 是一种选择性EZH2抑制剂,Ki 值为 24 nM,对其选择性是对 EZH1 的 50 倍,对其他 15 种甲基转移酶的 500 倍。
T9584 UNC6934

Others; Histone Methyltransferase Chromatin/Epigenetic; Others
UNC6934 是一种针对 NSD2 的 N 端 PWWP (PWWP1) 结构域的化学探针,可定位核仁。
T2435 EPZ011989

Histone Methyltransferase Chromatin/Epigenetic
EPZ011989是一种高选择性可口服的 EZH2抑制剂,对wt EZH2以及EZH2突变型Ki 值<3nM。
T15201 MAK683

Histone Methyltransferase Chromatin/Epigenetic
MAK683 是胚胎外胚层发育 (EED) 抑制剂。在 EED Alphascreen 结合、LC-MS 和 ELISA 测定中,IC50值为 59、89 和 26 nM。
T6900 MS023

Histone Methyltransferase Chromatin/Epigenetic
MS023 是一种有效的、选择性的、细胞活性的 I 型 PRMT 抑制剂,对 PRMT1、PRMT3、PRMT4、PRMT6和 PRMT8的 IC50分别为 30、119、83、4 和 5 nM。
T7089 SGC2085

Histone Methyltransferase Chromatin/Epigenetic
SGC2085是一种高效选择性CARM1抑制剂,IC50值为50 nM。
T10205 A-395

Histone Methyltransferase Chromatin/Epigenetic
A-395 是一种多梳抑制复合物 2 (PRC2) 蛋白质-蛋白质相互作用的拮抗剂,可有效抑制三聚体 PRC2 复合物 (EZH2-EED-SUZ12),IC50为 18 nM。

化合物

Histone H3 (1-35) acetate
Cat.No: T38766L
Synonym:
Target: Others
Histone Acetyltransferase Inhibitor II
Cat.No: T11563
Synonym:
Target: Epigenetic Reader Domain, Histone Acetyltransferase
M344
Cat.No: T2157
Synonym: MS 344,Histone Deacetylase Inhibitor III
Target: HDAC
Histone H1-derived Peptide
Cat.No: T41019
Synonym: Histone H1-derived Peptide
Target:
Histone H3 (1-21)
Cat.No: T40993
Synonym: Histone H3 (1-21)
Target:
Histone H3 (1-35)
Cat.No: T38766
Synonym: Histone H3 (1-35)
Target:
Histone H3 (21-44)
Cat.No: T38785
Synonym: Histone H3 (21-44)
Target:
Histone H3 (23-34)
Cat.No: T39580
Synonym: Histone H3 (23-34)
Target:
Histone H3 (5-23)
Cat.No: T40407
Synonym: Histone H3 (5-23)
Target:
Histone H3 (1-25), amide
Cat.No: T38784
Synonym: Histone H3 (1-25), amide
Target:
Histone H3 (116-136), C116-136
Cat.No: T41061
Synonym: Histone H3 (116-136), C116-136
Target:
NKL 22
Cat.No: T3206
Synonym: Histone Deacetylase Inhibitor IV,PAOA
Target: HDAC
Histone H3K27Me1 (23-34) (trifluoroacetate salt)
Cat.No: T36980
Synonym: Histone H3K27Me1 (23-34) (trifluoroacetate salt)
Target: Others
Histone acetyltransferase p300 Inhibitor 4c
Cat.No: T77560
Synonym:
Target: Carbonic Anhydrase, AChE
Histone H3 (21-44)-GK-biotin (trifluoroacetate salt)
Cat.No: T36576
Synonym: Histone H3 (21-44)-GK-biotin (trifluoroacetate salt)
Target: Others
Histone H3 (21-44)-GK-biotin amide (trifluoroacetate salt)
Cat.No: T36979
Synonym: Histone H3 (21-44)-GK-biotin amide (trifluoroacetate salt)
Target: Others
Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt)
Cat.No: T36095
Synonym: Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt)
Target: Others
K-Biotin-W-Histone H2B (108-125) (trifluoroacetate salt)
Cat.No: T36577
Synonym: K-Biotin-W-Histone H2B (108-125) (trifluoroacetate salt)
Target: Others
Pimelic diphenylamide 106
Cat.No: T3193
Synonym: Histone Deacetylase Inhibitor VII,TC-H 106,RGFA-8
Target: HDAC
Histone H4 (2-21)
Cat.No: TP1536
Synonym:
Target:
Histone-H2A-(107-122)-Ac-OH
Cat.No: TP2257
Synonym:
Target: Others
Histone H3 Antibody #9715R
Cat.No: T64592
Synonym:
Target: Others
PBIT
Cat.No: T16435
Synonym:
Target: Histone Demethylase, Histone Methyltransferase
L002
Cat.No: T11807
Synonym:
Target: Others, Histone Acetyltransferase, STAT
PFI-90
Cat.No: T9243
Synonym:
Target: Histone Demethylase, Others
CPTH2
Cat.No: T8344
Synonym:
Target: Apoptosis, Histone Acetyltransferase
Remodelin
Cat.No: T3499
Synonym:
Target: Histone Acetyltransferase
CXD101
Cat.No: T5347
Synonym: CXD-101
Target: HDAC
Tubacin
Cat.No: T6327
Synonym:
Target: Virus Protease, HDAC
H1-7 (histone H1 phosphorylation site), PKA Substrate
Cat.No: T76381
Synonym:
Target:
Nexturastat A
Cat.No: T1819
Synonym:
Target: HDAC
Pyroxamide
Cat.No: T7664
Synonym:
Target: Apoptosis, HDAC
TTK21
Cat.No: T8778
Synonym:
Target: Epigenetic Reader Domain
Acetyl-Histone H3 (Lys9) (C5B11) Rabbit mAb #9649R
Cat.No: T64611
Synonym:
Target: Others
Quisinostat
Cat.No: T6055
Synonym: 奎诺司他,JNJ-26481585
Target: Apoptosis, HDAC, Autophagy
SKLB-23bb
Cat.No: T5830
Synonym:
Target: HDAC
Elevenostat
Cat.No: T9745
Synonym:
Target: HDAC
MOZ-IN-2
Cat.No: T12098
Synonym:
Target: Histone Acetyltransferase
MPI_5a
Cat.No: T16129
Synonym:
Target: HDAC
BCI-121
Cat.No: T5322
Synonym:
Target: Histone Methyltransferase
SGC707
Cat.No: T3084
Synonym:
Target: Histone Methyltransferase
GSK503
Cat.No: T1775
Synonym:
Target: Histone Methyltransferase
UNC3866
Cat.No: T4021
Synonym:
Target: Histone Methyltransferase
EPZ005687
Cat.No: T1905
Synonym:
Target: Histone Methyltransferase
UNC6934
Cat.No: T9584
Synonym:
Target: Others, Histone Methyltransferase
EPZ011989
Cat.No: T2435
Synonym:
Target: Histone Methyltransferase
MAK683
Cat.No: T15201
Synonym:
Target: Histone Methyltransferase
MS023
Cat.No: T6900
Synonym:
Target: Histone Methyltransferase
SGC2085
Cat.No: T7089
Synonym:
Target: Histone Methyltransferase
A-395
Cat.No: T10205
Synonym:
Target: Histone Methyltransferase
Cat. No. Product Name Target Signaling Pathways
T8201 Gambogenic acid

Histone Methyltransferase Chromatin/Epigenetic
Gambogenic acid 是黄藤中的一种有效成分,具有抗癌活性。它是特异性EZH2抑制剂,与 EZH2-SET 结构域的 Cys668 位点共价结合,诱导 EZH2 泛素化。
T6803 Chaetocin

毛壳素

Histone Methyltransferase; Antibacterial; Antibiotic Chromatin/Epigenetic; Microbiology/Virology
Chaetocin 特异性抑制组蛋白甲基转移酶(HMT) SU(VAR)3-9,IC50值为0.6 μM。它还可抑制硫氧还蛋白还原酶,IC50值为4 μM。
TQ0207 Sulforaphane

萝卜硫素

Apoptosis; Nrf2; HDAC Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation
Sulforaphane 是存在于多种蔬菜中的一种天然异硫氰酸酯。它可以激活Nrf2,并通过 AMPK 依赖性信号传导抑制高糖诱导的胰腺癌。它增加肿瘤抑制蛋白的转录并抑制组蛋白脱乙酰酶的活性,具有抗癌和抗炎活性。
T3719 Daminozide

Succinic Acid,DMASA,Aminozide,丁酰肼

Histone Demethylase Chromatin/Epigenetic
Daminozide (Succinic Acid) 是一种植物生长调节剂,选择性地抑制 KDM2/7 JmjC 亚家族,对PHF8、KDM2A 和KIAA1718的IC50值分别为 0.55、1.5 和 2.1 μM。
T7052 Gnetol

Tyrosinase; COX; HDAC; AChR Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Neuroscience; Proteases/Proteasome
Gnetol 是从买麻藤的根中分离出来的一种酚类。它是酪氨酸酶抑制剂,对鼠酪氨酸酶的 IC50为 4.5 μM,可抑制黑色素的生物合成。它有效抑制 COX-1和 HDAC,具有抗氧化、抗增殖、抗癌和保肝活性,还具有浓度依赖性的 α-淀粉酶、α-葡萄糖苷酶和脂肪形成活性。
T2266 SantacruzaMate A

CAY-10683

HDAC Chromatin/Epigenetic; DNA Damage/DNA Repair
SantacruzaMate A (CAY-10683) 是一种高效选择性的HDAC2抑制剂,IC50为 119 pM。
T11366 Garcinol

Apoptosis; Endogenous Metabolite; Histone Acetyltransferase; AChR; AChE Apoptosis; Chromatin/Epigenetic; Metabolism; Neuroscience
Garcinol 是一种从印度藤黄提取的聚异戊二烯基二苯甲酮,对乙酰胆碱酯酶和丁酰胆碱酯酶具有抗胆碱酯酶的特性,IC50分别为 0.66 µM 和 7.39 µM。它还抑制组蛋白乙酰转移酶和 p300/CPB 相关因子,具有抗炎和抗癌活性。
T6270 Trichostatin A

曲古柳菌素A,曲古抑菌素A,TSA

HDAC Chromatin/Epigenetic; DNA Damage/DNA Repair
Trichostatin A (TSA) 属于二烯异羟肟酸类的天然衍生物。Trichostatin A 是一种组蛋白去乙酰化酶抑制剂 (IC50=1.8 nM),具有可逆性和特异性。Trichostatin A 导致核心组蛋白过度乙酰化,从而调节染色质结构。
TN1150 Procyanidin B3

原花青素B3,原花青素 B3

Histone Acetyltransferase Chromatin/Epigenetic
Procyanidin B3 是从葡萄中提取的一种黄酮类天然产物,是组蛋白乙酰转移酶特异性抑制剂,可与 p300的其他位点而非活性位点结合,选择性抑制 p300 介导的 androgen 受体乙酰化。
T5368 Eicosapentaenoic Acid

Histone Demethylase; Others; Endogenous Metabolite Chromatin/Epigenetic; Metabolism; Others
Eicosapentaenoic Acid 是一种 ω-3 脂肪酸。
TN1911 Marein

马里苷,马里甙

transporter; Akt; HDAC; AMPK Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling
Marein 能通过CaMKK/AMPK/GLUT1促进葡萄糖摄取,IRS/Akt/GSK-3β增加糖原合成,并通过Akt/FoxO1减少糖异生,从而改善 HepG2 细胞中高葡萄糖诱导的胰岛素抵抗。它对甲基乙二醛诱导的 PC12 细胞损伤具有神经保护作用,还有抗氧化、降压、降血脂和抗糖尿病作用。
T3753 Sinapinic Acid

Sinapic acid,芥子酸,Synapoic acid

Apoptosis; RAAS; Reactive Oxygen Species; HDAC Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB
Sinapinic Acid (Synapoic acid) 是从 Hydnophytum formicarumJack. 根中分离到的酚类,是HDAC 抑制剂,对ACE-I 的活性也有抑制作用。它有抗肿瘤活性,诱导肿瘤细胞凋亡,具有抗氧化、抗糖尿病的作用。
T6389 Anacardic Acid

漆树酸,6-pentadecylsalicylic Acid,Hydroginkgolic acid

Others; Epigenetic Reader Domain; Histone Acetyltransferase; Antibacterial Chromatin/Epigenetic; Microbiology/Virology; Others
Anacardic Acid (6-pentadecylsalicylic Acid) 是从腰果壳中提取液中分离到的酸类物质,是一种组蛋白乙酰转移酶抑制剂,对 p300 和 PCAF 的 IC50值分别为 ∼8.5 μM 和 ∼5 μM。
T6S0033 Crotonoside

巴豆苷;异鸟苷,巴豆苷,Isoguanosine,2-HYDROXYADENOSINE

Others; FLT; HDAC Angiogenesis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Others; Tyrosine Kinase/Adaptors
Crotonoside (Isoguanosine) 是从中草药巴豆中分离出来的一种天然产物。 它抑制 FLT3 和 HDAC3/6,有治疗急性髓性白血病 (AML)的研究潜力。
T0065 Acetaminophen

对乙酰氨基酚,醋氨酚,4-Acetamidophenol,4'-Hydroxyacetanilide,APAP,Paracetamol

COX; Endogenous Metabolite; Histone Acetyltransferase Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; Neuroscience
Acetaminophen (APAP) 是一种 COX 抑制剂,抑制 COX-1 和 COX-2 (IC50=113.7/25.8 μM)。Acetaminophen 具有解热镇痛活性,以及较弱的抗炎活性。
T1516 Curcumin

Diferuloylmethane,Natural Yellow 3,姜黄素,Indian Saffron,Turmeric yellow

Mitophagy; Epigenetic Reader Domain; Ferroptosis; Influenza Virus; Nrf2; Histone Acetyltransferase; HDAC; Autophagy Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology
Curcumin (Natural Yellow 3) 属于酚类天然产物,是一种组蛋白乙酰化转移酶 p300/CREB 的抑制剂 (IC50=25 μM),具有特异性。Curcumin 具有抗肿瘤、抗炎和抗氧化等多种药理活性。
T7064 Valproic Acid

Sodium valproate,2-Propylpentanoic Acid,丙戊酸,VPA,Depakine,2-Propylvaleric Acid

Mitophagy; Gamma-secretase; HIV Protease; GABA Receptor; Sodium Channel; HDAC; Autophagy Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome; Stem Cells
Valproic Acid (2-Propylpentanoic Acid) 是一种 HDAC 抑制剂,可抑制 HDAC1 活性,诱导 HDAC2 降解,具有口服活性。Valproic Acid 可以用于癫痫和躁郁症的研究。
T64353 4-tert-Octylphenol

Endogenous Metabolite Metabolism
4-tert-Octylphenol 是一种干扰内分泌的化学物质及雌激素药物,能诱导子代小鼠脑神经元祖细胞的凋亡,并通过减少溴脱氧尿苷(BrdU)、有丝分裂标志物Ki67以及磷酸组蛋白H3(p-Histone-H3)的表达,导致神经元祖细胞的增殖减少。这种物质不仅会干扰小鼠的大脑发育,还会影响其行为。
T3878 Raddeanin A

NSC382873,竹节香附素A,Anemodeanin A,Raddeanin R3

Apoptosis; HDAC Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
Raddeanin A (NSC-382873) 是竹节香附中的一种天然三萜皂苷,可抑制组蛋白去乙酰化酶,具有很强的抗血管生成能力和抗肿瘤活性。
T14305 Apicidin

OSI 2040

Apoptosis; HDAC; Autophagy Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair
Apicidin (OSI 2040) 是组蛋白去乙酰化酶(HDAC)抑制剂,具有抗寄生虫活性和抗增殖活性。Apicidin 通过减少 APP/PS1 小鼠中的 Abeta 负荷来减轻记忆缺陷,抑制细胞生长增殖,诱导细胞凋亡和自噬,可用于研究白血病。
T5066 Nε,Nε,Nε-Trimethyllysine chloride

Lys(Me)3-OH Chloride,Nε,Nε,Nε-Trimethyllysine hydrochloride

Others; Endogenous Metabolite Metabolism; Others
Nε,Nε,Nε-Trimethyllysine chloride (Lys(Me)3-OH Chloride) 是肠道菌群依赖性形成 N,N,N-trimethyl-5-aminovaleric acid (TMAVA) 的前体。
T37067 9-hydroxy Stearic Acid

HDAC Chromatin/Epigenetic; DNA Damage/DNA Repair
9-hydroxy Stearic Acid 是一种羟基脂肪酸,是9-PAHSA 的活性代谢物。9-hydroxy Stearic Acid 是由9-PAHSA 通过肝脏和胰腺的羧基酯脂肪酶形成的。9-hydroxy Stearic Acid (5 μM)抑制HT-29结肠癌细胞裂解物中组蛋白去乙酰化酶1 (HDAC1)的表达。3 .当浓度为100 μM.1时,可抑制HT-29细胞的增殖,并诱导细胞周期阻滞于G0/ g1期。
TN1567 Delphinidin chloride

Estrogen Receptor/ERR; VEGFR Angiogenesis; Endocrinology/Hormones; Tyrosine Kinase/Adaptors
Delphinidin chloride 是一种花青素,是一种可从浆果和红酒中分离得到的天然植物色素,是某些花青素的前体。Delphinidin chloride 诱导血管内皮释放一氧化氮,引起血管松弛。在1 ~ 40 μM 剂量下,对上皮生长因子受体的信号传导和雌激素受体α的表达有抑制作用,与细胞凋亡和自噬有关。Delphinidin chloride 能调节 JAK/STAT3 和 MAPKinase 信号传导。Delphinidin 还能抑制 p300/CBP 的组蛋白乙酰转移酶活性(IC50 在约为30 μM)
T13749 L-2-Hydroxyglutaric acid

(S)-2-Hydroxyglutaric acid

Others Others
L-2-Hydroxyglutaric acid, an epigenetic modifier and potential oncometabolite in renal cancer, impedes mitochondrial creatine kinase (Mi-CK) activity, exhibiting Km and Ki values of 2.52 mM and 11.13 mM, respectively. Additionally, it obstructs histone demethylases, thereby encouraging histone methylation.
T70778 Depudecin

Others Others
Depudecin is a polyketide obtained from the fungus Alternaria brassicicola and having a highly unusual structure of an 11-carbon chain containing two epoxides and six stereogenic centres. It is an inhibitor of histone deacetylase (HDAC) both in vivo and in vitro and also exhibits anti-angiogenic activity.
T75767 Parasin I TFA

Others Others
Parasin I (TFA) 是一种含有19个氨基酸残基的多肽,源自鲶鱼皮肤中分离出的组蛋白H2A,具备抗菌功能。
T36797 1-Alaninechlamydocin

Others Others
1-Alaninechalmydocin is a fungal metabolite originally isolated from a Great Lakes-derived Tolypocladium sp. and an inhibitor of histone deacetylases (HDACs). It reduces total HDAC activity in HeLa cell lysates in a concentration-dependent manner. 1-Alaninechlamydocin reduces proliferation of MIA PaCa-2, PANC-1, and hTERT-HPNE cells (GI50s = 5.3, 14, and 2.0 nM, respectively).
T74368 OKI-006

Others Others
OKI-006 是一种有效的、具有口服活性的组蛋白脱乙酰酶 (HDAC) 抑制剂。OKI-006 是天然产物HDAC 抑制剂 largazole 的独特同系物。组蛋白去乙酰化酶 (HDAC) 在表观基因组调控中起关键作用,并且组蛋白乙酰化在许多人类癌症中失调。OKI-006 具有研究癌症疾病的潜力。
TN2646 16-Hydroxycleroda-3,13-dien-15,16-olide

Autophagy Autophagy
16-Hydroxycleroda-3,13-dien-15,16-olide, and prodigiosin are presented as candidates for autophagy inducers that can trigger cell death in a supplement or alternative medicine for cancer therapy. 16-Hydroxycleroda-3,13-dien-15,16-olide regulates the expre
TN3070 4beta-Hydroxywithanolide E

PARP; HSP; NF-κB; COX Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB
4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progression and develop into a dietary chemopreventive agent, it affects alternative splicing by mo

天然产物

Gambogenic acid
Cat.No: T8201
Synonym:
Target: Histone Methyltransferase
Chaetocin
Cat.No: T6803
Synonym: 毛壳素
Target: Histone Methyltransferase, Antibacterial, Antibiotic
Sulforaphane
Cat.No: TQ0207
Synonym: 萝卜硫素
Target: Apoptosis, Nrf2, HDAC
Daminozide
Cat.No: T3719
Synonym: Succinic Acid,DMASA,Aminozide,丁酰肼
Target: Histone Demethylase
Gnetol
Cat.No: T7052
Synonym:
Target: Tyrosinase, COX, HDAC, AChR
SantacruzaMate A
Cat.No: T2266
Synonym: CAY-10683
Target: HDAC
Garcinol
Cat.No: T11366
Synonym:
Target: Apoptosis, Endogenous Metabolite, Histone Acetyltransferase, AChR, AChE
Trichostatin A
Cat.No: T6270
Synonym: 曲古柳菌素A,曲古抑菌素A,TSA
Target: HDAC
Procyanidin B3
Cat.No: TN1150
Synonym: 原花青素B3,原花青素 B3
Target: Histone Acetyltransferase
Eicosapentaenoic Acid
Cat.No: T5368
Synonym:
Target: Histone Demethylase, Others, Endogenous Metabolite
Marein
Cat.No: TN1911
Synonym: 马里苷,马里甙
Target: transporter, Akt, HDAC, AMPK
Sinapinic Acid
Cat.No: T3753
Synonym: Sinapic acid,芥子酸,Synapoic acid
Target: Apoptosis, RAAS, Reactive Oxygen Species, HDAC
Anacardic Acid
Cat.No: T6389
Synonym: 漆树酸,6-pentadecylsalicylic Acid,Hydroginkgolic acid
Target: Others, Epigenetic Reader Domain, Histone Acetyltransferase, Antibacterial
Crotonoside
Cat.No: T6S0033
Synonym: 巴豆苷;异鸟苷,巴豆苷,Isoguanosine,2-HYDROXYADENOSINE
Target: Others, FLT, HDAC
Acetaminophen
Cat.No: T0065
Synonym: 对乙酰氨基酚,醋氨酚,4-Acetamidophenol,4'-Hydroxyacetanilide,APAP,Paracetamol
Target: COX, Endogenous Metabolite, Histone Acetyltransferase
Curcumin
Cat.No: T1516
Synonym: Diferuloylmethane,Natural Yellow 3,姜黄素,Indian Saffron,Turmeric yellow
Target: Mitophagy, Epigenetic Reader Domain, Ferroptosis, Influenza Virus, Nrf2, Histone Acetyltransferase, HDAC, Autophagy
Valproic Acid
Cat.No: T7064
Synonym: Sodium valproate,2-Propylpentanoic Acid,丙戊酸,VPA,Depakine,2-Propylvaleric Acid
Target: Mitophagy, Gamma-secretase, HIV Protease, GABA Receptor, Sodium Channel, HDAC, Autophagy
4-tert-Octylphenol
Cat.No: T64353
Synonym:
Target: Endogenous Metabolite
Raddeanin A
Cat.No: T3878
Synonym: NSC382873,竹节香附素A,Anemodeanin A,Raddeanin R3
Target: Apoptosis, HDAC
Apicidin
Cat.No: T14305
Synonym: OSI 2040
Target: Apoptosis, HDAC, Autophagy
Nε,Nε,Nε-Trimethyllysine chloride
Cat.No: T5066
Synonym: Lys(Me)3-OH Chloride,Nε,Nε,Nε-Trimethyllysine hydrochloride
Target: Others, Endogenous Metabolite
9-hydroxy Stearic Acid
Cat.No: T37067
Synonym:
Target: HDAC
Delphinidin chloride
Cat.No: TN1567
Synonym:
Target: Estrogen Receptor/ERR, VEGFR
L-2-Hydroxyglutaric acid
Cat.No: T13749
Synonym: (S)-2-Hydroxyglutaric acid
Target: Others
Depudecin
Cat.No: T70778
Synonym:
Target: Others
Parasin I TFA
Cat.No: T75767
Synonym:
Target: Others
1-Alaninechlamydocin
Cat.No: T36797
Synonym:
Target: Others
OKI-006
Cat.No: T74368
Synonym:
Target: Others
16-Hydroxycleroda-3,13-dien-15,16-olide
Cat.No: TN2646
Synonym:
Target: Autophagy
4beta-Hydroxywithanolide E
Cat.No: TN3070
Synonym:
Target: PARP, HSP, NF-κB, COX
Cat. No. Product Name Species Expression System
TMPY-02580 Histone H1 Protein, Human, Recombinant (His)

HSP60,HSP65,CPN60,H1 histone family, member 0,H10,H...

Human E. coli
H1 histone family, member 0 (H1F0) is a member of the H1 histone family of nuclear proteins which are a component of chromatin in eukaryotic cells. It's involved in maintaining the structure of chromatin by packing the "beads on a string" sub-structure into a high order structure. The lysine-rich H1 histone family in mammals includes eleven members. In higher eukaryotes, all H1 variants have the same general structure, consisting of a central conserved globular domain and less conserved N-termin...
TMPH-01477 Histone H1.3 Protein, Human, Recombinant (His & MBP)

Histone H1s-2,H1-3,Histone H1.3,Histon...

Human E. coli
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. HIST1H1D Protein, Human, Recombinant (His & MBP) is expressed in E. coli expression system with N-MBP and C-6xHis tag. The predicted molecula...
TMPY-02521 HIST3H2A Protein, Human, Recombinant

histone cluster 3, H2a,MGC3165

Human E. coli
Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. There are subtype diversities: H1, H2A, H2B, and H3 or H4. It has become more and more evident that histone modifications are key players in the regulation of chromatin states and dynamics as well as in gene expression. Therefore, histone modifications and the enzymatic machinery that set them are crucial regulators that can control cellular proliferation, differentiation,...
TMPY-01333 HDAC8 Protein, Human, Recombinant (GST)

histone deacetylase 8,CDA07,MRXS6,RPD3,CDLS5,WTS,HD...

Human Baculovirus Insect Cells
HDAC8 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 68 kDa and the accession number is Q9BY41-1.
TMPY-03431 HDAC4 Protein, Human, Recombinant (aa 612-1084)

histone deacetylase 4,HA6116,HDAC-4,HD4,BDMR,HDAC-A...

Human Baculovirus Insect Cells
HDAC4 (histone deacetylase 4), belongs to class II of the histone deacetylase/AcuC/APhA family. Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional repression. In general, they do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. Th...
TMPY-01332 HIST1H3A Protein, Human, Mouse, Recombinant

Histone H3.1,histone cluster 1, H3a,Hi...

Human,Mouse E. coli
Histone H3.1, also known as HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J, is a member of the histone H3 family which is a core component of nucleosome. It is expressed during the S phase, then expression strongly decreases as cell division slows down during the process of differentiation. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machinery which requires DNA as a template. Histones thereby pla...
TMPH-01479 H2AFX Protein, Human, Recombinant (GST)

H2AX,Histone H2A.X,Histone H2AX

Human E. coli
H2AFX Protein, Human, Recombinant (GST) is expressed in E. coli.
TMPH-01480 H2BC3 Protein, Human, Recombinant (His & SUMO)

H2BC3,Histone H2B type 1-B,Histone H2B.f,<...

Human E. coli
H2BC3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
TMPH-02710 HIST1H2BA Protein, Mouse, Recombinant (His & Myc)

Histone H2B type 1-A,Histone H2B, testis,H...

Mouse E. coli
HIST1H2BA Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli.
TMPY-02317 HDAC8 Protein, Mouse, Recombinant (His)

histone deacetylase 8,2610007D20Rik

Mouse Baculovirus Insect Cells
HDAC8 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 43.1 kDa and the accession number is Q8VH37-1.
TMPY-04092 Histone H4 Protein, Human, Recombinant

HIST1H4E,H4FK,HIST1H4J,H4/M,HIST1H4A,H4FD,H4FC,H4/J,H4FN,H4F...

Human E. coli
Histone H4 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 11.4 kDa and the accession number is B2R4R0.
TMPH-01476 HDAC9 Protein, Human, Recombinant (His)

HDAC9,Histone deacetylase-related protein,MEF2-inte...

Human E. coli
HDAC9 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-01478 H2A.1 Protein, Human, Recombinant (His)

H2AC16,H2AC17,H2AC13,Histone H2A/ptl,H2AC15,His...

Human E. coli
HIST1H2AG Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-00095 HDT2 Protein, Arabidopsis thaliana, Recombinant (His)

Histone deacetylase HDT2,Histone deacetyla...

Arabidopsis thaliana P. pastoris (Yeast)
Probably mediates the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. HDT2 Protein, Arabidopsis thaliana, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 34.3 kDa and the accession number is Q56WH4.
TMPH-01472 HDAC11 Protein, Human, Recombinant (GST)

HDAC11,Histone deacetylase 11

Human E. coli
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC11 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 66....
TMPH-01482 HPF1 Protein, Human, Recombinant (His & Myc & SUMO)

Histone PARylation factor 1,HPF1

Human E. coli
HPF1 Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 59.4 kDa and the accession number is Q9NWY4.
TMPY-01708 DOT1L Protein, Human, Recombinant

DOT1,KMT4,DOT1-like histone H3K79 methyltransferase

Human E. coli
Histone-lysine N-methyltransferase, H3 lysine-79 specific, also known as Histone H3-K79 methyltransferase, DOT1-like protein, Lysine N-methyltransferase 4 and DOT1L, is a nucleus protein which belongs to theDOT1 family. In contrast to other lysine histone methyltransferase, DOT1L does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones. DOT1L is an histone methyltransferase. It methylates 'Lys-79' of histone H3. Nucleosome...
TMPY-03341 ASF1B Protein, Human, Recombinant (His)

anti-silencing function 1B histone chaperone,CIA-II

Human Baculovirus Insect Cells
The histone chaperone anti-silencing factor 1a (ASF1a) interacts with MDC1 and is recruited to sites of DSBs to facilitate the interaction of phospho-ATM with MDC1 and phosphorylation of MDC1, which are required for the recruitment of RNF8/RNF168 histone ubiquitin ligases. Thus, ASF1a deficiency reduces histone ubiquitination at DSBs, decreasing the recruitment of 53BP1, and decreases NHEJ, rendering cells more sensitive to DSBs. This role of ASF1a in DSB repair cannot be provided by the closely...
TMPH-02711 H2B type 1-M Protein, Mouse, Recombinant (His)

Histone H2B type 1-M,H2bc14,H2B 291B

Mouse E. coli
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. HIST1H2BM Protein, Mouse, Recombinant (His) is expressed in E...
TMPH-02463 HMf-2 Protein, Methanothermus fervidus, Recombinant (His)

Archaeal histone B,hmfB,DNA-binding protein HMf-2

Methanothermus fervidus E. coli
Binds and compacts DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation in vitro. HMf-2 Protein, Methanothermus fervidus, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 11.7 kDa and the accession number is P19267.
TMPH-02462 HMf-1 Protein, Methanothermus fervidus, Recombinant (His & Myc)

Archaeal histone A,hmfA,DNA-binding protein HMf-1

Methanothermus fervidus E. coli
Binds and compacts DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation. HMf-1 Protein, Methanothermus fervidus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 14.9 kDa and the accession number is P48781.
TMPH-01471 HDAC1 Protein, Human, Recombinant (His & SUMO)

Histone deacetylase 1,Protein deacetylase HDAC1,HDA...

Human E. coli
HDAC1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 71.1 kDa and the accession number is Q13547.
TMPH-01483 RBBP7 Protein, Human, Recombinant (His & SUMO)

Histone acetyltransferase type B subunit 2,Hist...

Human E. coli
RBBP7 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 63.8 kDa and the accession number is Q16576.
TMPH-01481 H2BC12 Protein, Human, Recombinant (His & Myc)

Histone H2B type 1-K,HIRA-interacting protein 1,H2B...

Human E. coli
H2BC12 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPH-03487 DNA-binding protein H-NS Protein, SerRatia marcescens, Recombinant (His)

hnsA,hns,Histone-like protein HLP-II,DNA-binding pr...

Serratia marcescens E. coli
A DNA-binding protein implicated in transcriptional repression and chromosome organization and compaction. Binds nucleation sites in AT-rich DNA and bridges them, forming higher-order nucleoprotein complexes and condensing the chromosome. As many horizontally transferred genes are AT-rich, it plays a central role in silencing foreign genes. A subset of genes are repressed by H-NS in association with other proteins. DNA-binding protein H-NS Protein, SerRatia marcescens, Recombinant (His) is expre...
TMPH-01474 HDAC6 Protein, Human, Recombinant (His)

Protein deacetylase HDAC6,Histone deacetylase 6,HDA...

Human E. coli
HDAC6 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-02105 ASH2L Protein, Human, Recombinant (His & SUMO)

ASH2-like protein,ASH2L,ASH2L1,Set1/Ash2 histone me...

Human E. coli
Transcriptional regulator. Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters. Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May p...
TMPH-01622 KDM3B Protein, Human, Recombinant (His & Myc & SUMO)

[histone H3]-dimethyl-L-lysine(9) demethylase 3B,Ly...

Human E. coli
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.
TMPH-01470 KAT5 Protein, Human, Recombinant (His)

Protein 2-hydroxyisobutyryltransferase KAT5,Lysine acetyltra...

Human E. coli
KAT5 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-01473 HDAC3 Protein, Human, Recombinant (His & SUMO)

Protein deacylase HDAC3,RPD3-2,Protein deacetylase HDAC3,

Human E. coli
HDAC3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 64.8 kDa and the accession number is O15379.
TMPH-02709 SAP130 Protein, Mouse, Recombinant (His)

Sap130,130 kDa Sin3-associated polypeptide,Sin3-associated p...

Mouse E. coli
Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. SAP130 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 28.8 kDa and the accession number is Q8BIH0.
TMPH-01526 KMT2E Protein, Human, Recombinant (His & Myc)

Inactive histone-lysine N-methyltransferase 2E,Myel...

Human E. coli
Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Also acts as an important cell cycle regulator, participating in cell cycle r...
TMPH-01776 HMGN2 Protein, Human, Recombinant (GST)

Non-histone chromosomal protein HMG-17,HMGN2,High m...

Human E. coli
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. HMGN2 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 36.4 kDa and the accession number is P05204.
TMPY-02510 HIST2H2BE Protein, Human, Recombinant

MGC129734,H2BGL105,H2B.1,histone cluster 2, H2be,H2...

Human E. coli
Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. Histone proteins exhibit two levels of diversity: 1. evolutionary diversity between species and 2. subtype diversity in a class(H1, H2A, H2B, H3 or H4) within a species. It has become more and more evident that histone modifications are key players in the regulation of chromatin states and dynamics as well as in gene expression. Therefore, histone modifications and the enz...
TMPJ-01399 ASF1A Protein, Human, Recombinant (His, T7)

CIA,Anti-Silencing Function Protein 1 Homolog A,ASF1A,Hi...

Human E. coli
Human Histone Chaperone ASF1A (ASF1A) belongs to the H3/H4 family of histone chaperone proteins. ASF1A is ubiquitously expressed in many cells and tissues, interacting with histones H3 and H4. ASF1A cooperates with Chromatin Assembly Factor 1 to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. In addition, ASF1A is necessary for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associat...
TMPH-01484 SMYD3 Protein, Human, Recombinant (His & Myc)

Zinc finger MYND domain-containing protein 1,SMYD3,SET and M...

Human E. coli
SMYD3 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPH-01908 JMJD1C Protein, Human, Recombinant (His & Myc & SUMO)

Probable JmjC domain-containing histone demethylati...

Human E. coli
JMJD1C Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli.
TMPH-00616 DNA-binding protein H-NS Protein, E. coli, Recombinant (His)

hns,DNA-binding protein H-NS,Protein B1,Protein H1,Heat-stab...

E. coli E. coli
A DNA-binding protein implicated in transcriptional repression (silencing). Also involved in bacterial chromosome organization and compaction. H-NS binds tightly to AT-rich dsDNA and inhibits transcription. Binds upstream and downstream of initiating RNA polymerase, trapping it in a loop and preventing transcription. Binds to hundreds of sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome. Many of these loci were horizontally transfe...
TMPY-00021 PADI4 Protein, Human, Recombinant (His)

PADI5,PAD4,PDI4,peptidyl arginine deiminase, type IV,PAD,PDI...

Human Baculovirus Insect Cells
Protein-arginine deiminase type-4, also known as HL-6 PAD, Peptidylarginine deiminase IV, Protein-arginine deiminase type I V and PADI4, is a cytoplasm and nucleus protein that belongs to the protein arginine deiminase family. PADI4 is expressed in CD34+stem cells in normal tissues, and many more CD34+ cells expressing PADI4 are present in tumour tissues. PADI4 post-translationally converts peptidylarginine to citrulline, a process called citrullination. Studies have demonstrated the high expres...
TMPH-03748 KAT14 Protein, Human, Recombinant (His)

KAT14,ADA2A-containing complex subunit 2,Cysteine-rich prote...

Human E. coli
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle.
TMPH-01698 MORC4 Protein, Human, Recombinant (His & Myc)

MORC4,Zinc finger CW-type domain protein 4,MORC family CW-ty...

Human E. coli
Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3. The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0.
TMPY-03498 ING4 Protein, Human, Recombinant (His)

inhibitor of growth family, member 4,p29ING4,my036

Human E. coli
ING4 is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. ING4 contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. ING4 protein can bind TP53 and EP3/p3, a component of the histone acetyltransferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. ING4 is a component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activi...
TMPY-02981 ING5 Protein, Human, Recombinant (GST)

p28ING5,inhibitor of growth family, member 5

Human E. coli
ING5 belongs to the ING family. It contains 1 PHD-type zinc finger and is a component of the HBO1 complex. HBO1 complex has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of PHF15, PHF16, and PHF17. ING5 also is a component of the MOZ/MORF complex which is composed at least of ING5, KAT6A, KAT6B, MEAF6, and one of BRP...
TMPY-01657 SUV420H2 Protein, Human, Recombinant (His & GST)

suppressor of variegation 4-20 homolog 2 (Drosophila),KMT5C

Human E. coli
Histone-lysine N-methyltransferase SUV42H2, also known as Suppressor of variegation 4-2 homolog 2, Su(var)4-2 homolog 2, Lysine N-methyltransferase 5C, SUV42H2 and KMT5C, is nucleus protein that belongs to the histone-lysine methyltransferase family and Suvar4-2 subfamily. SUV42H2 is a histone methyltransferase that specifically trimethylates 'Lys-2' of histone H4. H4 'Lys-2' trimethylation represents a specific tag for epigenetic transcriptional repression. SUV42H2 mainly functions in pericentr...
TMPY-01229 SETD7 Protein, Human, Recombinant (His)

SET7/9,SET domain containing (lysine methyltransferase) 7,SE...

Human E. coli
Histone-lysine N-methyltransferase SETD7, also known as SET domain containing (lysine methyltransferase) 7, SET7/9, Histone H3-K4 methyltransferase SETD7, H3-K4-HMTase SETD7, and SETD7, is a member of the histone-lysine methyltransferase family and SET7 subfamily. SETD7 is widely expressed and expressed in pancreatic islets. SETD7 contains three MORN repeats and one SET domain. SETD7 plays a central role in the transcriptional activation of genes such as collagenase or insulin. As a protein lysi...
TMPH-03040 HupB Protein, MenB, Recombinant (His)

DNA-binding protein HU-beta,hupB

MenB E. coli
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
TMPH-01803 NAP1L4 Protein, Human, Recombinant (His & Myc)

Nucleosome assembly protein 2,Nucleosome assembly protein 1-...

Human E. coli
Acts as histone chaperone in nucleosome assembly. NAP1L4 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 50.1 kDa and the accession number is Q99733.
TMPH-01697 MORC3 Protein, Human, Recombinant (His & SUMO)

Zinc finger CW-type coiled-coil domain protein 3,MORC3,Nucle...

Human E. coli
Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism. Sumoylated MORC3-NBs can also associate with PML-NBs. Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity. Binds RNA in vitro. May be required for influenza A transcription during viral infection. Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3. The order of binding preference is ...
TMPH-02227 ERG Protein, Human, Recombinant (His)

Transcriptional regulator ERG,Transforming protein ERG,ERG

Human P. pastoris (Yeast)
Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure. ERG Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 56.6 kDa and the accession number is P11308.
TMPH-01088 CBX5 Protein, Human, Recombinant (His & Myc)

HP1 alpha,CBX5,Heterochromatin protein 1 homolog alpha,Chrom...

Human E. coli
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. CBX5 Protein...
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重组蛋白

Histone H1 Protein, Human, Recombinant (His)
Cat.No: TMPY-02580
Species: Human
Expression System: E. coli
Histone H1.3 Protein, Human, Recombinant (His & MBP)
Cat.No: TMPH-01477
Species: Human
Expression System: E. coli
HIST3H2A Protein, Human, Recombinant
Cat.No: TMPY-02521
Species: Human
Expression System: E. coli
HDAC8 Protein, Human, Recombinant (GST)
Cat.No: TMPY-01333
Species: Human
Expression System: Baculovirus Insect Cells
HDAC4 Protein, Human, Recombinant (aa 612-1084)
Cat.No: TMPY-03431
Species: Human
Expression System: Baculovirus Insect Cells
HIST1H3A Protein, Human, Mouse, Recombinant
Cat.No: TMPY-01332
Species: Human,Mouse
Expression System: E. coli
H2AFX Protein, Human, Recombinant (GST)
Cat.No: TMPH-01479
Species: Human
Expression System: E. coli
H2BC3 Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-01480
Species: Human
Expression System: E. coli
HIST1H2BA Protein, Mouse, Recombinant (His & Myc)
Cat.No: TMPH-02710
Species: Mouse
Expression System: E. coli
HDAC8 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-02317
Species: Mouse
Expression System: Baculovirus Insect Cells
Histone H4 Protein, Human, Recombinant
Cat.No: TMPY-04092
Species: Human
Expression System: E. coli
HDAC9 Protein, Human, Recombinant (His)
Cat.No: TMPH-01476
Species: Human
Expression System: E. coli
H2A.1 Protein, Human, Recombinant (His)
Cat.No: TMPH-01478
Species: Human
Expression System: E. coli
HDT2 Protein, Arabidopsis thaliana, Recombinant (His)
Cat.No: TMPH-00095
Species: Arabidopsis thaliana
Expression System: P. pastoris (Yeast)
HDAC11 Protein, Human, Recombinant (GST)
Cat.No: TMPH-01472
Species: Human
Expression System: E. coli
HPF1 Protein, Human, Recombinant (His & Myc & SUMO)
Cat.No: TMPH-01482
Species: Human
Expression System: E. coli
DOT1L Protein, Human, Recombinant
Cat.No: TMPY-01708
Species: Human
Expression System: E. coli
ASF1B Protein, Human, Recombinant (His)
Cat.No: TMPY-03341
Species: Human
Expression System: Baculovirus Insect Cells
H2B type 1-M Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02711
Species: Mouse
Expression System: E. coli
HMf-2 Protein, Methanothermus fervidus, Recombinant (His)
Cat.No: TMPH-02463
Species: Methanothermus fervidus
Expression System: E. coli
HMf-1 Protein, Methanothermus fervidus, Recombinant (His & Myc)
Cat.No: TMPH-02462
Species: Methanothermus fervidus
Expression System: E. coli
HDAC1 Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-01471
Species: Human
Expression System: E. coli
RBBP7 Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-01483
Species: Human
Expression System: E. coli
H2BC12 Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01481
Species: Human
Expression System: E. coli
DNA-binding protein H-NS Protein, SerRatia marcescens, Recombinant (His)
Cat.No: TMPH-03487
Species: Serratia marcescens
Expression System: E. coli
HDAC6 Protein, Human, Recombinant (His)
Cat.No: TMPH-01474
Species: Human
Expression System: E. coli
ASH2L Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-02105
Species: Human
Expression System: E. coli
KDM3B Protein, Human, Recombinant (His & Myc & SUMO)
Cat.No: TMPH-01622
Species: Human
Expression System: E. coli
KAT5 Protein, Human, Recombinant (His)
Cat.No: TMPH-01470
Species: Human
Expression System: E. coli
HDAC3 Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-01473
Species: Human
Expression System: E. coli
SAP130 Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02709
Species: Mouse
Expression System: E. coli
KMT2E Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01526
Species: Human
Expression System: E. coli
HMGN2 Protein, Human, Recombinant (GST)
Cat.No: TMPH-01776
Species: Human
Expression System: E. coli
HIST2H2BE Protein, Human, Recombinant
Cat.No: TMPY-02510
Species: Human
Expression System: E. coli
ASF1A Protein, Human, Recombinant (His, T7)
Cat.No: TMPJ-01399
Species: Human
Expression System: E. coli
SMYD3 Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01484
Species: Human
Expression System: E. coli
JMJD1C Protein, Human, Recombinant (His & Myc & SUMO)
Cat.No: TMPH-01908
Species: Human
Expression System: E. coli
DNA-binding protein H-NS Protein, E. coli, Recombinant (His)
Cat.No: TMPH-00616
Species: E. coli
Expression System: E. coli
PADI4 Protein, Human, Recombinant (His)
Cat.No: TMPY-00021
Species: Human
Expression System: Baculovirus Insect Cells
KAT14 Protein, Human, Recombinant (His)
Cat.No: TMPH-03748
Species: Human
Expression System: E. coli
MORC4 Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01698
Species: Human
Expression System: E. coli
ING4 Protein, Human, Recombinant (His)
Cat.No: TMPY-03498
Species: Human
Expression System: E. coli
ING5 Protein, Human, Recombinant (GST)
Cat.No: TMPY-02981
Species: Human
Expression System: E. coli
SUV420H2 Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-01657
Species: Human
Expression System: E. coli
SETD7 Protein, Human, Recombinant (His)
Cat.No: TMPY-01229
Species: Human
Expression System: E. coli
HupB Protein, MenB, Recombinant (His)
Cat.No: TMPH-03040
Species: MenB
Expression System: E. coli
NAP1L4 Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01803
Species: Human
Expression System: E. coli
MORC3 Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-01697
Species: Human
Expression System: E. coli
ERG Protein, Human, Recombinant (His)
Cat.No: TMPH-02227
Species: Human
Expression System: P. pastoris (Yeast)
CBX5 Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01088
Species: Human
Expression System: E. coli
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Cat. No. Product Name Target Signaling Pathways
TMIJ-0163 Valproic Acid-d4

Valproic Acid-d4 是 Valproic Acid 的氘代化合物。Valproic Acid 的 CAS 号为 99-66-1。Valproic acid是一种 HDAC 抑制剂,可抑制HDAC1的活性,同时可诱导HDAC2的降解。它激活Notch1信号并抑制小细胞肺癌细胞的增殖。它可研究癫痫、双相情感障碍和偏头痛等。
TMIJ-0431 2-(Propyl-3,3,3-d3)pentanoic-5,5,5-d3 Acid

2-(Propyl-3,3,3-d3)pentanoic-5,5,5-d3 Acid 是 2-pentanoic Acid 的氘代化合物。2-pentanoic Acid 的 CAS 号为 99-66-1。Valproic acid是一种 HDAC 抑制剂,可抑制HDAC1的活性,同时可诱导HDAC2的降解。它激活Notch1信号并抑制小细胞肺癌细胞的增殖。它可研究癫痫、双相情感障碍和偏头痛等。
TMID-0120 Valproic Acid-d15

Valproic Acid-d15 是 Valproic Acid 的氘代化合物。Valproic Acid 的 CAS 号为 99-66-1。Valproic acid是一种 HDAC 抑制剂,可抑制HDAC1的活性,同时可诱导HDAC2的降解。它激活Notch1信号并抑制小细胞肺癌细胞的增殖。它可研究癫痫、双相情感障碍和偏头痛等。
T10901 Curcumin-d6

Turmeric yellow D6,Natural Yellow 3 D6,Curcumin D6,Diferuloylmethane D6

Others Others
Curcumin D6 (difluoroformylmethane D6) is deuterium-labeled curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with various pharmacological effects, including anti-inflammatory, antioxidant, anti-proliferative and anti-a
TMIJ-0050 Butyricacid-d7

Butyricacid-d7 是 Butyricacid 的氘代化合物。Butyricacid 的 CAS 号为 107-92-6。Butyric acid 是一种从许多乳制品中分离出来的脂肪酸,具有抗癌活性。 它抑制组蛋白去乙酰化酶 (HDAC) 并诱导胶质瘤细胞凋亡和 G1 期细胞周期停滞。此外,它在低剂量时刺激上皮细胞增殖,在高剂量时抑制增殖。

同位素标记化合物

Valproic Acid-d4
Cat.No: TMIJ-0163
Synonym:
Target:
2-(Propyl-3,3,3-d3)pentanoic-5,5,5-d3 Acid
Cat.No: TMIJ-0431
Synonym:
Target:
Valproic Acid-d15
Cat.No: TMID-0120
Synonym:
Target:
Curcumin-d6
Cat.No: T10901
Synonym: Turmeric yellow D6,Natural Yellow 3 D6,Curcumin D6,Diferuloylmethane D6
Target: Others
Butyricacid-d7
Cat.No: TMIJ-0050
Synonym:
Target:
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