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Search Results for " histamine h3 receptor "

Targets Recommended: Histamine Receptor

59

抑制剂 & 化合物

1

天然产物

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同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T6164	Ciproxifan FUB-359,环丙基[4-[3-(1H-咪唑-4-基)丙氧基]苯基]甲酮马来酸盐	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Ciproxifan (FUB-359) 是一种高效且特异性的组胺 H3 受体拮抗剂，IC50值为 9.2 nM，可用于研究衰老性疾病和阿尔兹海默症。
T41247	Thioperamide maleate MR-12842 maleate,硫丙咪胺马来酸	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Thioperamide maleate (MR-12842 maleate) 是一种有效且选择性的 H3 受体拮抗剂 (Ki = 4.3 nM)，可抑制 [3H]histamine 的合成 (Ki = 31 nM)。
T23038L	Nα-Methylhistamine FA Nα-Methylhistamine FA（673-50-7 Free base)	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Nα-Methylhistamine FA 是一种组胺H3受体激动剂。
T27678	JNJ-39220675 JNJ 39220675,JNJ39220675	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	JNJ-39220675 (JNJ 39220675) 是一种具有选择性和脑渗透性的组胺 H3 受体拮抗剂。
T12054	MK-0249 MK 0249,MK0249	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	MK-0249 是一种具有口服活性、选择性和高效性的 histamine H3 受体拮抗剂（IC50：1.7 nM），可用于研究注意力缺陷和多动障碍。
T7413	JNJ-5207852	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	JNJ-5207852 是一种新型的非咪唑组胺 H3 受体拮抗剂，其对大鼠和人 H3 受体的 pKi 值分别为 8.9 和9.24。
T8822	JNJ-5207852 dihydrochloride	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	JNJ-5207852 dihydrochloride 是一种新型的非咪唑组胺 H3 受体拮抗剂，对大鼠和人类 H3受体的 pKi 值分别为 8.9 和 9.24。
TQ0066	GSK189254A GSK189254	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	GSK189254A (GSK189254) 是一种有效的特异性组胺 H3 受体拮抗剂，对人类和大鼠H3的pKi 值分别为9.59到9.90和8.51到9.17之间。
T67828	Enerisant TS-091	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Enerisant (TS-091) 是一种具有口服活性、选择性和高效性的组胺 H3 受体拮抗剂，在小鼠体内以剂量依赖的方式调节组胺H3受体。Enerisant 可促进促认知作，可逆转东莨菪碱诱导的认知障碍。
T79500L	KSK94 FA KSK94 FA(2566716-07-0 Free base)	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	KSK94 FA 是一种高效的组胺 H3 受体拮抗剂，抑制 H3 受体，可用于研究神经性疼痛和肥胖症。
T7176	Pitolisant hydrochloride 1-[3-[3-(4-氯丙基)丙氧基]丙基]-哌啶盐酸盐,BF 2649,Ciproxidine	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Pitolisant hydrochloride (Ciproxidine) 是一种有效的、选择性的组胺 H3 受体反向激动剂，Ki 为0.16 nM。
T14087	ABT-239	TRP/TRPV Channel	Membrane transporter/Ion channel
	ABT-239是一种新型、高效、非咪唑类H3R 拮抗剂，也是一种TRPV1拮抗剂。
T70489	Enerisant HCl	P450; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
	Enerisant HCl是一种新型强效选择性组胺H3受体拮抗剂，是P-gp的底物，由细胞色素P450（CYP）和转运蛋白介导。
T16476	PF-03654746	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	PF-03654746 是组胺 H3 受体的选择性拮抗剂。 PF-03654746 提高了阿尔茨海默病的认知功效和疾病改善作用。 PF-03654746 可用于治疗过敏性鼻炎的研究。
T60636	Pitolisant Tiprolisant,BF-2.649,BF-2649	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Pitolisant (Tiprolisant) 是一种具有选择性和高效性的非咪唑类重组人组胺 H3 受体拮抗剂，可用于研究发作性睡病患者白天过度嗜睡和猝倒。
T22864	Immethridine dihydrobromide	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Immethridine dihydrobromide 是一种新型高效且具有选择性的组胺 H3 受体 (H3R) 激动剂，抑制树突状细胞的功能，可缓解实验性自身免疫性脑脊髓炎。Immethridine dihydrobromide MesV 诱导神经元和MMN去极化，可防止心肾损伤。
T79499	KSK68	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	KSK68 是一种高效的 sigma-1 和组胺 H3 受体双重拮抗剂，具有潜在的镇痛活性，对 H3 受体、sigma-1、sigma-2 受体有很高的亲和力。KSK68 可用于研究与疼痛相关的疾病。
T0246	Betahistine dihydrochloride PT-9,Betahistine 2HCl,盐酸倍他司汀	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Betahistine dihydrochloride (Betahistine 2HCl) 是可口服的组胺 H1 受体激动剂和 H3 受体的拮抗剂，可用作血管扩张剂，用于类风湿性关节炎的研究。
T32191	Irdabisant CEP-26401,CEP 26401,CEP26401	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Irdabisant (CEP-26401) 是选择性、口服活性和血脑屏障渗透性的组胺 H3 受体 (histamine H3 receptor, H3R) 拮抗剂/逆激动剂。Irdabisant 显示人 H3R 和大鼠 H3R 的 Ki 分别为 2.0 nM 和 7.2 nM。Irdabisant 抑制 hERG 电流的活性相对较低 (IC50= 13.8 μM)。在大鼠社会认知模型中，Irdabisant 具有认知增强和唤醒作用。Irdabisant 可用于研究精神分裂症或认知障碍。
T0246L	Betahistine mesylate Extovyl,甲磺酸倍他司汀,Melopat,Meginalisk	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Betahistine mesylate (Extovyl) 是可口服的组胺 H1 受体激动剂和 H3 受体的拮抗剂，可用作血管扩张剂，用于类风湿性关节炎的研究。
T8514	LML134 LML-134	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	LML134 (LML-134) 是一种可口服的高选择性组胺 H3 受体反向激动剂，有用于过度睡眠障碍的潜力，对 hH3R 的 cAMP 和 bdg 的Kis 分别为 0.3 和 12 nM。
T4195	Betahistine PT 9 base,倍他司汀,Vasomotal,Serc base	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Betahistine (Vasomotal) 是可口服的组胺 H1 受体激动剂和 H3 受体的拮抗剂，可用作血管扩张剂，用于类风湿性关节炎的研究。
T14970	Cipralisant GT-2331	Others	Others
	Cipralisant is a selective histamine H3 receptor antagonist in vivo, and an agonist in vitro (pKi: 9.9 for histamine H3 receptor; Ki: 0.47 nM for rat histamine H3 receptor). It has the potential for the treatment of attention-deficit hyperactivity disorde
T27473	GSK334429 GSK-334429,GSK 334429	Others	Others
	GSK334429 is an antagonist of histamine H3 receptor.
T23519	VUF 5681 dihydrobromide	Others	Others
	histamine H3 receptor silent antagonist
T22878	JNJ 10181457 dihydrochloride	Others	Others
	JNJ 10181457 dihydrochloride is a Histamine H3 receptor antagonist.
T23038	Nα-Methylhistamine dihydrochloride	Others	Others
	Nα-Methylhistamine dihydrochloride is a histamine H3 receptor agonist.
T23190	Proxyfan oxalate	Others	Others
	histamine H3 receptor ligand
T70111	GT-2394	Others	Others
	GT-2394 is a histamine H3 receptor agonist.
T70112	GT-2227	Others	Others
	GT-2227 is a histamine H3 receptor antagonist.
T29043	UCL-1972 UCL 1972	Others	Others
	UCL-1972, a Histamine H3 Receptor Antagonist, used to treat cognitive disorders.
T69756	GT-2331	Others	Others
	GT-2331 is a histamine H3 receptor antagonist.
T22866	Impentamine dihydrobromide	Others	Others
	Impentamine dihydrobromide is a histamine H3 receptor antagonist.
T71270	ZEL-H16	Others	Others
	ZEL-H16 is an agonist of the histamine H3 receptor.
T12416	PF-03654746 Tosylate	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	PF-03654746 Tosylate is selective antagonist of histamine H3 receptor with high brain penetration.
T22863	Immepip dihydrobromide	Others	Others
	Immepip dihydrobromide is a histamine H3 receptor agonist.
T24698	(R)-(-)-α-Methylhistamine dihydrochloride HISTAMINE DIHYDROCHLORIDE R(-)-A-METHYL	Others	Others
	R(-)-alpha-Methylhistamine 2HCl is an effective and selective agonist of the H3 histamine receptor.
T26480	A331440 A-331440,A331440 free base,A 331440	Others	Others
	A331440 is an modulator of L-histidine and histamine H3 receptor.
T10911	H3 receptor antagonist 1	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	H3 receptor antagonist 1 is used in the study of neurological diseases, histamine H3 receptor antagonist.
T26643	Aplysamine-1 Aplysamine	Others	Others
	Aplysamine-1 is an antagonist of histamine H3 receptor.
T10499	H3 receptor-MO-1	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	H3 receptor-MO-1 是一种有效的组胺 H3 受体 (histamine H3 receptor) 调节剂，可用于研究神经分裂和认知障碍。
T27022	Cipralisant maleate GT-2331,Cipralisant maleate. trade name Perceptin,GT 2331,GT2331	Others	Others
	Cipralisant maleate is a potent, selective Histamine H3 receptor antagonist.
T12630	(R)-(-)-α-Methylhistamine dihydrobromide	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	(R)-(-)-α-Methylhistamine dihydrobromide is a potent and selective agonist of H3 histamine receptor( Kd of 50.3 nM).
T71605	APD-916 dicitrate	Others	Others
	APD-916 dicitrate is a potent and selective inverse agonist of the histamine H3 receptor.
T19628	GSK 189254 HCl GSK-189254A,GSK 189254A,GSK 189254 hydrochloride,GSK189254A	Others	Others
	GSK 189254A is a histamine H3 receptor antagonist for the treatment of narcolepsy. Histamine H3 receptor antagonists have been shown to increase the release of neurotransmitters in the brain and to enhance cognition in vivo. The compound may also be usefu
T68521	MK-3134	Others	Others
	MK-3134 is a novel histamine H3 receptor inverse agonist.
T69654	VUF16839	Others	Others
	VUF16839 is a high-affinity non-imidazole histamine H3 receptor agonist.
T12491	Pitolisant oxalate Tiprolisant oxalate	Others	Others
	Pitolisant oxalate is a potent and selective inverse agonist of nonimidazole at the recombinant human histamine H3 receptor with Ki of 0.16 nM.
T19762	Clobenpropit 2HBr VUF-9153,VUF 9153,Clobenpropit Dihydrobromide,VUF9153	Others	Others
	Clobenpropit 2HBr is a histamine H3 receptor antagonist. It has neuroprotective effects via stimulation of GABA release in the brain.
T15590	Iodophenpropit dihydrobromide	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Iodophenpropit dihydrobromide is an effective and selective antagonist of the histamine H3 receptor. The binding of [125I]Iodophenpropit is readily reversible, selective, and of high affinity (KD: 0.32 nM).

化合物

Cat.No: T6164

Synonym: FUB-359,环丙基[4-[3-(1H-咪唑-4-基)丙氧基]苯基]甲酮马来酸盐

Target: Histamine Receptor

Thioperamide maleate

Cat.No: T41247

Synonym: MR-12842 maleate,硫丙咪胺马来酸

Target: Histamine Receptor

Nα-Methylhistamine FA

Cat.No: T23038L

Synonym: Nα-Methylhistamine FA（673-50-7 Free base)

Target: Histamine Receptor

Cat.No: T27678

Synonym: JNJ 39220675,JNJ39220675

Target: Histamine Receptor

Cat.No: T12054

Synonym: MK 0249,MK0249

Target: Histamine Receptor

Cat.No: T7413

Target: Histamine Receptor

JNJ-5207852 dihydrochloride

Cat.No: T8822

Target: Histamine Receptor

Cat.No: TQ0066

Synonym: GSK189254

Target: Histamine Receptor

Cat.No: T67828

Synonym: TS-091

Target: Histamine Receptor

Cat.No: T79500L

Synonym: KSK94 FA(2566716-07-0 Free base)

Target: Histamine Receptor

Pitolisant hydrochloride

Cat.No: T7176

Synonym: 1-[3-[3-(4-氯丙基)丙氧基]丙基]-哌啶盐酸盐,BF 2649,Ciproxidine

Target: Histamine Receptor

Cat.No: T14087

Target: TRP/TRPV Channel

Cat.No: T70489

Target: P450, Histamine Receptor

Cat.No: T16476

Target: Histamine Receptor

Cat.No: T60636

Synonym: Tiprolisant,BF-2.649,BF-2649

Target: Histamine Receptor

Immethridine dihydrobromide

Cat.No: T22864

Target: Histamine Receptor

Cat.No: T79499

Target: Histamine Receptor

Betahistine dihydrochloride

Cat.No: T0246

Synonym: PT-9,Betahistine 2HCl,盐酸倍他司汀

Target: Histamine Receptor

Cat.No: T32191

Synonym: CEP-26401,CEP 26401,CEP26401

Target: Histamine Receptor

Betahistine mesylate

Cat.No: T0246L

Synonym: Extovyl,甲磺酸倍他司汀,Melopat,Meginalisk

Target: Histamine Receptor

Cat.No: T8514

Synonym: LML-134

Target: Histamine Receptor

Cat.No: T4195

Synonym: PT 9 base,倍他司汀,Vasomotal,Serc base

Target: Histamine Receptor

Cat.No: T14970

Synonym: GT-2331

Target: Others

Cat.No: T27473

Synonym: GSK-334429,GSK 334429

Target: Others

VUF 5681 dihydrobromide

Cat.No: T23519

Target: Others

JNJ 10181457 dihydrochloride

Cat.No: T22878

Target: Others

Nα-Methylhistamine dihydrochloride

Cat.No: T23038

Target: Others

Proxyfan oxalate

Cat.No: T23190

Target: Others

Cat.No: T70111

Target: Others

Cat.No: T70112

Target: Others

Cat.No: T29043

Synonym: UCL 1972

Target: Others

Cat.No: T69756

Target: Others

Impentamine dihydrobromide

Cat.No: T22866

Target: Others

Cat.No: T71270

Target: Others

PF-03654746 Tosylate

Cat.No: T12416

Target: Histamine Receptor

Immepip dihydrobromide

Cat.No: T22863

Target: Others

(R)-(-)-α-Methylhistamine dihydrochloride

Cat.No: T24698

Synonym: HISTAMINE DIHYDROCHLORIDE R(-)-A-METHYL

Target: Others

Cat.No: T26480

Synonym: A-331440,A331440 free base,A 331440

Target: Others

H3 receptor antagonist 1

Cat.No: T10911

Target: Histamine Receptor

Cat.No: T26643

Synonym: Aplysamine

Target: Others

H3 receptor-MO-1

Cat.No: T10499

Target: Histamine Receptor

Cipralisant maleate

Cat.No: T27022

Synonym: GT-2331,Cipralisant maleate. trade name Perceptin,GT 2331,GT2331

Target: Others

(R)-(-)-α-Methylhistamine dihydrobromide

Cat.No: T12630

Target: Histamine Receptor

APD-916 dicitrate

Cat.No: T71605

Target: Others

Cat.No: T19628

Synonym: GSK-189254A,GSK 189254A,GSK 189254 hydrochloride,GSK189254A

Target: Others

Cat.No: T68521

Target: Others

Cat.No: T69654

Target: Others

Pitolisant oxalate

Cat.No: T12491

Synonym: Tiprolisant oxalate

Target: Others

Clobenpropit 2HBr

Cat.No: T19762

Synonym: VUF-9153,VUF 9153,Clobenpropit Dihydrobromide,VUF9153

Target: Others

Iodophenpropit dihydrobromide

Cat.No: T15590

Target: Histamine Receptor

Cat. No.	Product Name	Target	Signaling Pathways
T20712	Conessine Conessinum,Wrightine,地麻素,Roquessine,Neriine,Konessin	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Conessine (Conessinum) 是一种具有抗疟活性的甾体生物碱，是高效选择性H3 受体拮抗剂，对于人、狗、豚鼠和大鼠 H3受体的Ki 分别为 5.4、6.0、5.7 和 25 nM。

天然产物

Cat.No: T20712

Synonym: Conessinum,Wrightine,地麻素,Roquessine,Neriine,Konessin

Target: Histamine Receptor

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0338	Pitolisant-d6 HCl
	Pitolisant-d6 HCl 是 Pitolisant HCl 的氘代化合物。Pitolisant HCl 的 CAS 号为 903576-44-3。Pitolisant hydrochloride 是一种有效的、选择性的组胺 H3 受体反向激动剂，Ki为0.16 nM。

同位素标记化合物

Pitolisant-d6 HCl

Cat.No: TMIJ-0338

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