1503
171
130
14
465
20
Cat. No. | Product Name | ||
---|---|---|---|
L7800 | 高溶解性片段库 | 2728 compounds | |
2728 种片段分子合集,数量适中,是 FBDD 方法新药筛选的有力工具。 | |||
L7820 | 高溶解性微型片段化合物库 | 1081 compounds | |
高溶解性微型片段化合物库由 1081 个低分子量片段组成。 | |||
L7830 | 高溶解性片段药效团化合物库 | 985 compounds | |
高溶解性片段药效团库包含985 个片段小分子。 | |||
L7840 | 高溶解性卤化片段化合物库 | 796 compounds | |
高溶解性卤化片段库包含796 个卤化片段化合物。 | |||
L7850 | 高溶解性3D结构多样性片段化合物库 | 1079 compounds | |
高溶解性3D 结构多样性片段库包含1079 个化合物。 | |||
L7810 | 高溶解性多官能团片段化合物库 | 1159 compounds | |
高溶解性多官能团片段库包含1159 种片段分子 | |||
LF1030 | LC高溶解性片段化合物库 | 9600 compounds | |
L2010 | 高选择性抑制剂库 | 575 compounds | |
575种具有高选择性的抑制剂集合 | |||
L6900 | 稀有天然产物库 | 693 compounds | |
693 种稀有天然产物的集合,可以用于高通量和高内涵筛选; | |||
LF1000 | 多样性核心预制库 | 50000 compounds | |
For your convenience, there are Diversity Sets of 5,000, 10,000, 15,000, and 20,000 compounds with no structure overlap. | |||
L9610 | 环肽库 | 80 compounds | |
80 种环肽分子,可用于高通量和高内涵筛选; | |||
L3410 | 临床前化合物库 | 701 compounds | |
701 种临床前小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L3900 | DNA 损伤和修复分子库 | 910 compounds | |
910 个与 DNA 损伤和修复紧密相关的化合物集合,是高通量筛选,高内涵筛选的良好载体; | |||
L6100 | 天然多酚类化合物库 | 635 compounds | |
635 个天然多酚化合物的独特集合,可用于高通量、高内涵筛选; | |||
L2000 | 抑制剂库 | 8328 compounds | |
8328 个小分子抑制剂的独特集合,主要用于细胞信号研究、新药筛选、高通量筛选和高内涵筛选; | |||
L6230 | 苗药化合物库 | 534 compounds | |
534种苗族特色药材的天然产物分子,可用于高通量和高内涵筛选 | |||
L6010 | 天然产物库 | 3840 compounds | |
3840 种天然产物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L1510 | 核受体化合物库 | 531 compounds | |
531 个核受体作用化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L2400 | 内分泌激素分子库 | 784 compounds | |
784 种与内分泌系统相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L8400 | 血液病分子库 | 514 compounds | |
514 种造血系统疾病相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L1200 | 表观遗传库 | 953 compounds | |
953 种表观遗传学研究相关的生物活性小分子的特有集合,用于表观遗传学研究及其相关的检测和高通量、高内涵筛选; | |||
L5400 | 抗心血管疾病化合物库 | 1408 compounds | |
1408 种心血管疾病相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L6220 | 蒙药化合物库 | 950 compounds | |
950 种蒙药来源的天然产物分子集合,可以用于高通量和高内涵筛选; | |||
L3600 | 细胞因子抑制剂库 | 604 compounds | |
604 个与细胞因子紧密相关的化合物集合,是高通量、高内涵筛选的良好载体; | |||
L2120 | 抗癌临床化合物库 | 2545 compounds | |
2545 个具有抗癌活性小分子的独特集合,可用于高通量高内涵筛选。 | |||
L7000 | 活性脂质化合物库 | 385 compounds | |
385 种生物活性小分子化合物,用于高通量、高内涵筛选; | |||
L6300 | 药食同源库 | 1290 compounds | |
1290 个药食同源化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L3700 | JAK-STAT 化合物库 | 252 compounds | |
252 个 JAK/STAT 靶点相关的小分子化合物的独特集合,用于高通量、高内涵筛选; | |||
L9200 | 药物功能重定位化合物库 | 4630 compounds | |
4630 种全球上市药物和临床药物的独特集合,可用于高通量筛选和高内涵筛选,是老药新用、新的药物靶点筛选和细胞诱导的有效工具。 | |||
L5500 | 毒性化合物库 | 262 compounds | |
262 个细胞毒性化合物的特有集合,可用于高通量、高内涵筛选。 | |||
L8300 | 染色质修饰分子库 | 250 compounds | |
250 种染色质化学修饰相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L2800 | 5-羟色胺分子库 | 268 compounds | |
268 种生物活性小分子化合物,用于高通量、高内涵筛选; | |||
L4100 | TGF-β/Smad靶点化合物库 | 184 compounds | |
184 个 TGF-β/Smad 靶点相关的小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L9850 | 口服活性化合物库 | 2427 compounds | |
2427 种口服活性化合物独特集合,可用于高通量筛选和高内涵筛选 | |||
L2910 | 抗氧化化合物库 | 1314 compounds | |
氧化应激(Oxidative Stress,OS)是指体内氧化与抗氧化作用失衡的一种状态。氧化应激导致活性氧(ROS)大量积累,氧化程度超出抗氧化物的清除能力,从而引起氧化损伤,氧化应激损伤是许多疾病发生的基础,不同程度的氧化应激造成的细胞效应与心脑血管疾病、神经退行性病变、炎症和肿瘤密切相关。抗氧化剂是一类能够对抗氧化应激,降低氧化损伤的一类化合物。 TargetMol 抗氧化化合物库是1314 种对氧化应激具有抑制作用的小分子特有集合,是研究氧化应激的有用工具,可以用于高通量筛选和高内涵筛选。 | |||
L6610 | 抗感染天然产物库 | 1060 compounds | |
1060 个抗感染相关的天然产物集合,是药物开发、药理研究的有效工具; | |||
L8000 | 干细胞分化化合物库 | 1197 compounds | |
1197 种干细胞分化信号通路相关的生物活性小分子化合物的特有集合,可用于高通量、高内涵筛选; | |||
L1000 | 上市药物库 | 2808 compounds | |
2808 个上市药物化合物集合,可用于高通量筛选和高内涵筛选; | |||
L2600 | 神经信号分子库 | 2540 compounds | |
2540 种CNS 相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L2152 | 靶向治疗药物库 | 119 compounds | |
119 个肿瘤靶向治疗药物,可以用于高通量和高内涵筛选; | |||
L2140 | 癌细胞分化化合物库 | 406 compounds | |
406 个诱导肿瘤细胞分化化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L2130 | 抗癌细胞代谢库 | 1268 compounds | |
1268 种癌细胞代谢相关的生物活性小分子化合物的特有集合,用于肿瘤相关的研究以及抗肿瘤药物的筛选,用于高通量、高内涵筛选; | |||
L1010 | FDA上市及药典收录分子库 | 3158 compounds | |
3158 个上市及药典分子集合,可用于高通量筛选和高内涵筛选; | |||
L9240 | 农药化合物库 | 270 compounds | |
270种农药相关化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L3980 | DNA损伤/修复库Plus | 667 compounds | |
667 种 DNA 损伤/修复靶向、结构新颖的化合物; | |||
L1600 | 激酶抑制剂库 | 2720 compounds | |
2720 种激酶抑制剂/调节剂的独特集合,用于特定靶向激酶,可用于高通量筛选和高内涵筛选; | |||
L9410 | 共价抑制剂库 | 1920 compounds | |
1920 种小分子的独特集合,包含已发现的共价抑制剂以及包含某些共价反应基团常见弹头的分子,如氯乙酰基,2-氯丙酰基,丙烯酰基,1-丙-2-炔基,1-丁-2-炔基,酮羰基,二硫键等,可以用于共价抑制剂药物研发; | |||
L2300 | 离子通道库 | 931 compounds | |
931 种与离子通道相关的生物活性小分子化合物的特有集合,用于离子通道相关的疾病和药物研究,可用于高通量筛选和高内涵筛选; | |||
L4300 | Wnt/Hedgehog/Notch 通路化合物库 | 237 compounds | |
237 个Wnt & Hedgehog & Notch 靶点相关的生物活性小分子化合物的特有集合,用于相关通路的研究及药物的筛选,可用于高通量、高内涵筛选。 | |||
L1610 | FDA 上市激酶抑制剂库 | 263 compounds | |
263种靶向激酶的上市药物集合,用于特定靶向激酶,可用于高通量筛选和高内涵筛选; | |||
L8600 | 泛素化化合物库 | 210 compounds | |
210 种泛素化相关的小分子,用于高通量和高内涵筛选; | |||
L1500 | GPCR靶点分子库 | 1940 compounds | |
1940 种与 G 蛋白及其耦联受体相关的生物活性小分子化合物,所有小分子都具有良好的生物和药理活性,部分是 FDA 批准的上市药物; | |||
L3800 | NF-κB 通路分子库 | 729 compounds | |
729 个 NF-κB 信号通路相关的小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L6210 | 藏药化合物库 | 747 compounds | |
747 种藏药来源的天然产物分子集合,可以用于高通量和高内涵筛选; | |||
L2195 | 抗前列腺癌化合物库 | 2070 compounds | |
2070 种与前列腺癌相关的化合物,可以用于高通量和高内涵筛选 | |||
L2900 | 氧化还原化合物库 | 1264 compounds | |
1264 个活性化合物,已经验证具有一定的抗氧化活性,包括 ROS 清除剂、iNOS、eNOS、及抗氧化的天然产物,是研究疾病机理以及药物研究的优良载体 | |||
L4200 | FDA 上市药物库 | 1729 compounds | |
1729 个FDA 批准药物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L7870 | 可溶性羧酸片段化合物库 | 1806 compounds | |
可溶性羧酸片段库包含 1806 个化合物 | |||
L5200 | 抗代谢疾病化合物库 | 1544 compounds | |
1544 个代谢疾病相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L1300 | PI3K/Akt/mTOR 化合物库 | 420 compounds | |
420 种与PI3K/Akt/mTOR 相关的生物活性小分子化合物的特有集合,用于PI3K/Akt/mTOR 相关研究以及高通量、高内涵筛选; | |||
L6200 | 瑶药化合物库 | 221 compounds | |
221 种瑶药来源的天然产物分子集合,可以用于高通量和高内涵筛选; | |||
L6700 | 抗癌天然产物库 | 1772 compounds | |
1772 种已知活性天然产物的独特集合,是肿瘤药物开发、抗癌先导化合物筛选等领域的有力工具,可用于HTS 和HCS。 | |||
L2191 | 抗乳腺癌化合物库 | 1939 compounds | |
1939 种与乳腺癌相关的化合物,可以用于抗乳腺癌药物研发和药理研究; | |||
L1800 | 抗感染化合物库 | 2938 compounds | |
2938 种具有抗感染活性的化合物的特有集合,包括抗细菌、抗真菌、抗巨细胞病毒、抗HIV、抗SARS、抗流感等活性; | |||
L3400 | 临床期小分子药物库 | 3404 compounds | |
3404 个临床期化合物集合,可用于高通量筛选和高内涵筛选; | |||
L4510 | 抗寄生虫库 | 419 compounds | |
419 种具有抗寄生虫活性的小分子化合物; | |||
L3100 | 造血毒性小分子库 | 101 compounds | |
101 种生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L2521 | 糖酵解化合物库 | 555 compounds | |
555 种糖酵解相关的活性化合物,可用于高通量和高内涵筛选 | |||
L2570 | 人代谢物化合物库 | 4454 compounds | |
4454 种人代谢物的独特集合,用于高通量、高内涵筛选; | |||
L1700 | 抗病毒库 | 1040 compounds | |
1040 种具有抗病毒活性的化合物的特有集合,是筛选新型抗病毒药的有效工具;可用于高通量筛选和高内涵筛选; | |||
L2151 | 化疗药物库 | 48 compounds | |
48 个肿瘤化疗药物,可以用于高通量和高内涵筛选; | |||
L5800 | 药物代谢杂质库 | 197 compounds | |
197 种药物异构体/代谢产物的特有集合,可用于高通量、高内涵筛选; | |||
L9230 | ReFRAME 相关化合物库 | 3210 compounds | |
3210 化合物的独特集合,可用于高通量筛选和高内涵筛选 | |||
L9210 | 儿童药物库 | 972 compounds | |
972 种儿童药物的独特集合,可用于高通量筛选和高内涵筛选 | |||
L7300 | 钾通道分子库 | 152 compounds | |
152 种钾通道相关化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L4710 | 非甾体类抗炎化合物库 | 530 compounds | |
530 种非甾体类的抗炎相关化合物,可用于高通量和高内涵筛选; | |||
L6001 | Mini真菌代谢天然产物筛选库 | Inquiry | |
L4020 | NO PAINS 化合物库 | 9384 compounds | |
TargetMol NO PAINS 化合物库包含 9384 个剔除了PAINS 的小分子活性化合物,可用于新药研发,信号通路研究,老药新用等研究。 | |||
L6030 | 天然产物衍生物虚筛化合物库 | 163000 compounds | |
16.3万种天然产物衍生物,并且在持续增加中; | |||
L2194 | 抗结直肠癌化合物库 | 1545 compounds | |
1545 种与结直肠癌相关的化合物,可以用于高通量和高内涵筛选; | |||
L3500 | 组蛋白修饰化合物库 | 469 compounds | |
469 个组蛋白修饰相关的小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L3200 | 自噬库 | 1248 compounds | |
1248 种细胞自噬相关的生物活性小分子化合物的特有集合,用于自噬相关的研究,用于高通量、高内涵筛选; | |||
L2200 | 酪氨酸激酶分子库 | 1016 compounds | |
1016 种酪氨酸激酶抑制剂的独特集合,可用于高通量筛选和高内涵筛选; | |||
L6400 | 海洋天然产物库 | 144 compounds | |
144 种海洋来源的单体化合物,是药物开发、药理研究等领域的有力工具; | |||
L2150 | 抗癌药物库 | 3080 compounds | |
3080 个具有抗癌活性小分子的独特集合,生物活性已经临床前实验证实,可用于高通量、高内涵筛选; | |||
L8720 | 细胞焦亡化合物库 | 1066 compounds | |
1066 种细胞焦亡相关的化合物,可以用于细胞焦亡相关研究。 | |||
L2560 | 代谢化合物库 | 2320 compounds | |
2320 种代谢途径相关的化合物,可用于高通量和高内涵筛选。 | |||
L2160 | 抗癌活性化合物库 | 3188 compounds | |
3188 种具有抗肿瘤活性的化合物的特有集合,用于高通量、高内涵筛选; | |||
L6130 | 萜类天然产物库 | 622 compounds | |
622 种萜类天然产物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L6620 | 抗寄生虫天然产物库 | 253 compounds | |
253 个抗寄生虫相关的天然产物集合,是药物开发、药理研究的有效工具; | |||
L6000 | 高通量筛选天然产物库 | 4533 compounds | |
4533 种天然产物的独特集合,是药物开发、药理研究、干细胞分化、指纹图谱研究、质量研究等领域的有力工具,可用于HTS 和HCS; | |||
L2100 | 抗癌化合物库 | 7234 compounds | |
7234 种肿瘤相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L8100 | 细胞周期化合物库 | 677 compounds | |
677 种细胞周期相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L6600 | 胃肠炎天然产物库 | 219 compounds | |
219 种胃肠炎相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L4800 | 血管生成库 | 1353 compounds | |
1353 个高潜力的抑制或促进血管生成的小分子集合,可用于药物靶点开发、血管生成机理研究的高通量筛选,高内涵筛选; | |||
L8200 | 抗衰老化合物库 | 3279 compounds | |
3279 个抗衰老化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L4000 | 经典已知活性库 | 14439 compounds | |
14439 个已知活性化合物的集合,可用于高通量筛选、高内涵筛选、细胞诱导和靶点确认; | |||
L5900 | 血脑屏障通透化合物库 | 509 compounds | |
509 个 CNS-Penetrant 生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L8110 | 细胞重编程化合物库 | 1813 compounds | |
1813 种重编程信号通路相关的生物活性小分子化合物的特有集合,可用于高通量、高内涵筛选 | |||
L2110 | 抗癌上市药物库 | 1779 compounds | |
1779 个具有抗癌活性小分子的独特集合,所有化合物都经过了严格的临床前研究和临床试验,由FDA、EMA 或NMPA 批准上市,可用于高通量、高内涵筛选。 | |||
L8110 | 细胞重编程化合物库 | 1813 compounds | |
1813 种重编程信号通路相关的生物活性小分子化合物的特有集合,可用于高通量、高内涵筛选 | |||
L9860 | 抗抑郁症化合物库 | 1163 compounds | |
1163 种与抑郁症相关的化合物,可以用于高通量和高内涵筛选 | |||
L3510 | 甲基化化合物库 | 128 compounds | |
128 种甲基化相关的化合物,可以用于高通量和高内涵筛选; | |||
L6110 | 生物碱类天然产物库 | 500 compounds | |
500 种生物碱类天然产物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L7500 | 凝血与抗凝化合物库 | 144 compounds | |
144 个化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L4010 | 已知活性化合物库 | 22555 compounds | |
22555 个已知活性化合物的集合,可用于高通量筛选、高内涵筛选、细胞诱导和靶点确认; | |||
L3300 | 组胺&褪黑色素化合物库 | 153 compounds | |
153 种生物活性小分子化合物,用于高通量、高内涵筛选; | |||
L7400 | 钠通道分子库 | 118 compounds | |
118 种钠通道相关化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L2500 | 人内源代谢化合物库 | 499 compounds | |
499 种内源性生物活性化合物的独特集合,用于高通量、高内涵筛选; | |||
L7200 | 钙通道分子库 | 140 compounds | |
140 种钙通道相关化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L7900 | 成骨分子库 | 317 compounds | |
317 种成骨相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L7700 | 神经再生化合物库 | 524 compounds | |
524 种神经再生相关化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L4700 | 免疫/炎症分子化合物库 | 4720 compounds | |
4720 种具有抗炎症活性的化合物的特有集合,可用于高通量筛选和高内涵筛选; | |||
L4600 | 植物来源化合物库 | 3048 compounds | |
3048 个植物来源天然产物的独特集合,来自277类植物的精心之选; | |||
L2510 | 脂代谢化合物库 | 492 compounds | |
492 个脂代谢相关的化合物集合,可用于高通量和高内涵筛选; | |||
L5100 | 含氟化合物库 | 574 compounds | |
574 个含氟化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L2550 | 谷氨酰胺代谢化合物库 | 565 compounds | |
565 种谷氨酰胺代谢相关的分子,可以用于高通量和高内涵筛选; | |||
L9500 | 表型筛选靶点鉴定库 | 1796 compounds | |
1796 种靶点明确的已知活性化合物,适合表型筛选; | |||
L6820 | 烟草单体化合物库 | 747 compounds | |
747种烟草单体化合物的独特集合,可用于高通量筛选和高内涵筛选 | |||
L9700 | 内质网应激化合物库 | 193 compounds | |
193 个内质网应激相关的化合物集合,可用于高通量和高内涵筛选; | |||
L6120 | 黄酮类天然产物库 | 514 compounds | |
514 种黄酮类天然产物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L9420 | 外泌体相关化合物库 | 76 compounds | |
76 种外泌体相关的化合物,可以用于高通量和高内涵筛选; | |||
L7100 | 抗肥胖化合物库 | 2247 compounds | |
2247 个抗肥胖化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L7600 | 趋化因子抑制剂库 | 59 compounds | |
59 种趋化因子或其受体抑制剂的独特集合,可用于高通量筛选和高内涵筛选; | |||
L1710 | 抗COVID-19化合物库 | 1133 compounds | |
1133 种对SARS-CoV-2有抑制作用或潜在抑制作用的化合物集合,可用于高通量和高内涵筛选; | |||
L2170 | 肿瘤免疫治疗小分子化合物库 | 449 compounds | |
449 种靶向肿瘤免疫治疗靶点的小分子,可用于高通量和高内涵筛选,是研究肿瘤免疫治疗的有力工具; | |||
L6500 | 微生物天然产物库 | 685 compounds | |
685 种微生物来源的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L9300 | 大环化合物库 | 210 compounds | |
210 种活性已知的大环化合物,用于高通量、高内涵筛选; | |||
DO1200 | 药物靶点库 | 53200 compounds | |
数量多,含53200种小分子化合物,是高通量筛选的有力工具; | |||
L7110 | 抗高血压化合物库 | 678 compounds | |
678 种高血压相关的小分子,用于高通量和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5471 |
GUANABENZ
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
GUANABENZ 是一种中枢 alpha-2 肾上腺素能激动剂。它的作用机制是作为肾上腺素能 α2-激动剂。 | |||
T2086 |
ELN-441958
ELN 441958 |
Bradykinin Receptor | GPCR/G Protein |
ELN-441958是一种B1受体拮抗剂,能够抑制B1激动剂配体[3H] DAKD 与IMR-90细胞结合(Ki:0.26 nM),相较于B2受体,它对B1受体的抑制作用具有更高的选择性,且比抑制μ阿片受体选择性高500多倍,比抑制δ阿片受体选择性高2000多倍。 | |||
T6054 |
GSK256066
|
PDE | Metabolism |
GSK256066 是高亲和力的、选择性的PDE4抑制剂,IC50=3.2 pM,被开发用于慢性阻塞性肺病的研究。 | |||
T13884 |
Shield-1
|
Others | Others |
Shield-1 是 FK506 结合蛋白 12 (FKBP) 的特异性、高亲和力和细胞渗透性配体,通过与突变的 FKBP (mtFKBP) 结合来逆转不稳定性,允许 mtFKBP 融合蛋白的条件表达。它可以稳定整个融合蛋白。 | |||
T11344 |
G150
|
DNA; cGAS | DNA Damage/DNA Repair; Immunology/Inflammation |
G150 是高选择性h-cGAS 抑制剂,IC50值为 10.2 nM,用于抑制 dsDNA 引发的干扰素表达。 | |||
T21957 |
Guanabenz hydrochloride
NE56490 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Guanabenz hydrochloride (NE56490) 是一种具有降血压作用的口服活性 α2-肾上腺素受体激动剂。 | |||
T7686 |
Ramiprilat
|
RAAS | Endocrinology/Hormones |
Ramiprilat 是 Ramipril 的活性代谢物,是一种口服有活力的血管紧张素转换酶 (ACE) 抑制剂,其 Ki=7 pM。它可用于研究心力衰竭以及高血压。 | |||
T33639 |
Neotame
NC 00723,HSDB 7965,NC-00723,NC00723,纽甜 |
Others | Others |
Neotame (HSDB 7965) 是阿斯巴甜的衍生物,是低热量、高效的人造甜味剂,非营养性甜味剂和增味剂,其甜度是糖的 7000-13,000 倍,可用于多种食品。 | |||
T6581 |
Methyclothiazide
Duretic,Enduron,甲氯噻嗪,Aquatensen |
Others; Carbonic Anhydrase | Metabolism; Others |
Methyclothiazide (Aquatensen) 是一种具有口服活性的利尿剂,也是一种降压剂。它能够拮抗体外的电压依赖性钙通道的 (VDCC) 活性,也可以抑制内源性血管收缩刺激导致的血管反应。 | |||
T4524 |
SBC-110736
SBC110736 |
Others; Serine/threonin kinase | Cell Cycle/Checkpoint; Metabolism; Others |
SBC-110736 是一种蛋白转化酶枯草杆菌蛋白酶 9 型 (PCSK9) 抑制剂。 | |||
T3283 |
Cetilistat
新利司他,ATL-962 |
Lipid | Metabolism |
Cetilistat (ATL-962) 是胰腺脂肪酶 (pancreatic lipase) 抑制剂,能够抑制大鼠脂肪酶(IC50:54.8 nM)和人胰脂肪酶(IC50:5.95 nM)的活性,可用作有效的抗肥胖药。 | |||
T14667 |
BLT-1
|
Others; HCV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
BLT-1 是一种氨基硫脲铜螯合剂,是一种选择性清除受体 B1 型 (SR-BI) 抑制剂,抑制高密度脂蛋白 (HDL) 和 SR-BI 介导的细胞之间的脂质转移。 | |||
T2499 |
Torcetrapib
CP-529414,托彻普 |
CETP | Metabolism |
是胆固醇酯转移蛋白 (CETP) 选择性抑制剂。根据人血浆的抑制曲线,Torcetrapib (CP-529414) 对CETP 的最有效浓度为 37 nM。 | |||
T0197 |
Terazosin hydrochloride
盐酸特拉唑嗪,Terazosin HCl,Terazosine,Blavin,Hytrin,Zayasel,Fosfomic |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Terazosin hydrochloride (Hytrin) 是一种竞争性和口服活性的 α1-肾上腺素受体拮抗剂,是一种喹唑啉衍生物。它通过舒张血管和打开膀胱来起作用。它可用于良性前列腺增生和高血压的研究。 | |||
T1050 |
Prazosin hydrochloride
Prazosin hydrochloride,哌唑嗪盐酸盐,Prazosin HCl,cp-12299-1,Peripress,Vasoflex,盐酸哌唑嗪,Minipress |
Potassium Channel; MRP; Adrenergic Receptor; ABC; Autophagy | Autophagy; GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience |
Prazosin hydrochloride (Vasoflex) 是一种选择性肾上腺素能 α-1 拮抗剂,可降低外周阻力并放松血管平滑肌。 它可用于研究高血压和酒精使用障碍。 它是一种合成哌嗪衍生物,具有降压抗肾上腺素能特性。它抑制有机阳离子转运蛋白 OCT-1 和 OCT-3,IC50分别为 1.8 和 13 μM 。 | |||
T20656 |
Verapamil
NSC 135784,维拉帕米,NSC-135784,CP-16533-1,(±)-Verapamil |
P450; Calcium Channel; P-gp | Membrane transporter/Ion channel; Metabolism; Neuroscience |
Verapamil (CP-16533-1) 是一种非二氢吡啶类钙通道阻滞剂,一种 P-gp 抑制剂,也是一种 CYP3A4 抑制剂,具有口服活性。Verapamil 可以用于治疗高血压、心绞痛、心肌梗塞等。 | |||
T1010 |
Verapamil hydrochloride
Manidon,盐酸维拉帕米,(±)-Verapamil hydrochlorid,Verapamil HCl,Calcan hydrochloride |
P450; Calcium Channel; P-gp | Membrane transporter/Ion channel; Metabolism; Neuroscience |
Verapamil hydrochloride (Verapamil HCl) 是一种钙通道阻滞剂,是一种可口服的 P 糖蛋白 (P-gp) 抑制剂,可抑制CYP3A4,用于高血压、心律不齐和心绞痛的研究。 | |||
T6701 |
Terazosin hydrochloride dihydrate
Flotrin dihydrate,Terazosin HCl Dihydrate,Dysalfa dihydrate,Heitrin dihydrate,盐酸特拉唑嗪(二水合物) |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Terazosin hydrochloride dihydrate (Heitrin dihydrate) 是一种竞争性和口服活性的 α1-肾上腺素受体(α1-adrenoceptor) 拮抗剂,是一种喹唑啉衍生物,通过舒张血管和打开膀胱的方式起作用。它可用于研究良性前列腺增生 (BPH) 和高血压。 | |||
T1203 |
Nadolol
Anabet,Corgard,Solgol,苯甲丁氮酮,纳多洛尔,SQ11725 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Nadolol 是一种有机阴离子转运多肽 1A2 (OATP1A2) 的底物,是一种非选择性的、具有口服活性的 β-肾上腺素受体 (β-adrenergic receptors) 阻滞剂,可用于高血压,心绞痛和血管性头痛的研究。 | |||
T10477 |
BAY-985
|
IκB/IKK | NF-κB |
BAY-985 是高效的、ATP 竞争性的、有口服活性的、选择性的TBK1和IKKε双重抑制剂,对 TBK1 (在低/高 ATP 实验中) 和 IKKε 的IC50分别为 2/30 和 2 nM。它具有抗肿瘤作用。 | |||
T12140 |
N-Acetyl-Calicheamicin
N-Acetyl-Calicheamicin γ,N-Acetyl-γ-calicheamicin |
Antibacterial; ADC Cytotoxin | Antibody-drug Conjugate/ADC Related; Microbiology/Virology |
N-Acetyl-Calicheamicin (N-Acetyl-γ-calicheamicin)是一种具有很高抗肿瘤活性的的抗生素。 | |||
T34383L |
2H-Naphth[2′,1′:4,5]indeno[1,2-d][1,3]dioxole, pregn-4-ene-3,20-dione deriv
|
Others | Others |
2H-Naphth[2′,1′:4,5]indeno[1,2-d][1,3]dioxole, pregn-4-ene-3,20-dione deriv在Sprague Dawley大鼠上进行测试时显示出高局部抗炎效力和高肺选择性。 | |||
T2229 |
Tetraethylenepentamine Pentahydrochloride
|
Others | Others |
Tetraethylenepentamine Pentahydrochloride 是一种高亲和力的铜和锌螯合剂。 | |||
T20761 |
RU 59063
RU-59063,RU59063 |
Androgen Receptor | Endocrinology/Hormones |
RU 59063 是一类新型高亲和力非甾体雄激素受体 (AR) 配体的原型。 | |||
T11864 |
Iptacopan
LNP023 |
Others | Others |
Iptacopan (LNP023) 是一种与factor B 亲和力较高的抑制剂。 | |||
T34994 |
Uk-390957
Uk390957,Uk 390957 |
Others | Others |
Uk-390957 是一种磺酰胺化合物,由于与碳酸酐酶结合而具有高BPR。 | |||
T9058 |
Bisphenoxyethanolfluorene
|
Others | Others |
Bisphenoxyethanolfluorene 是一种高稳定性的新型有机化工原料,主要用于合成耐热、透明性和高折射率的高分子单体。 | |||
T15581 |
Inolitazone
RS5444,Efatutazone,CS-7017,伊诺他酮 |
PPAR | DNA Damage/DNA Repair; Metabolism |
Inolitazone (RS5444) 是一种高亲和力PPARγ激动剂。在体外,Inotazone 显示生长抑制的IC50约为0.8 nM。 | |||
T31362 |
Deferitazole
SPD602,FBS 0701,SPD-602,FBS0701,FBS-0701,SPD 602 |
Others | Others |
Deferitazole (FBS 0701) 是一种新型且具有口服活性、选择性和高亲和力的铁螯合剂。 | |||
T34383 |
Rofleponide
|
Glucocorticoid Receptor | Endocrinology/Hormones |
Rofleponide 是一种人工合成的糖皮质激素,与大鼠胸腺糖皮质激素受体有很高的亲和力。 | |||
T26085 |
Rilapine
Rilapinum |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Rilapine (Rilapinum) 是一种抗精神病化合物,对 5-HT6 受体显示出较高亲和力,可以用于研究神经系统疾病。 | |||
TP1044L |
Pancreatic Polypeptide, rat acetate
|
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
Pancreatic Polypeptide, rat acetate 是 NPY 受体的激动剂,对 NPYR4 具有高亲和力。 | |||
T9501 |
Enterobactin
Enterochelin |
Others | Others |
Enterobactin (Enterochelin) 是一种高亲和力铁载体,可为微生物系统获取铁。 | |||
T9989 |
AChE-IN-27
|
Others | Others |
AChE-IN-27是一种用于高通量测定的小分子。 | |||
T11349 |
GABAA receptor agent 1
|
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
GABAA receptor agent 1 是GABAA 受体的高亲和力配体,有抗惊厥活性。 | |||
T15364 |
G-1
|
Estrogen Receptor/ERR; GPR | Endocrinology/Hormones; GPCR/G Protein |
G-1 是一种高亲和力的、非甾体的、有选择性的 GPR30激动剂(Ki:11 nM)。 | |||
T7021 |
ZM241385
|
Adenosine Receptor | GPCR/G Protein; Neuroscience |
ZM241385 是一种高亲和力的,选择性的腺苷A2AR 拮抗剂,Ki 值为 1.4 nM。 | |||
T7716 |
TNCA
(S)-2,3,4,9-四氢-1H-吡啶[3,4-B]吲哚-3-羧酸,Lycoperodine-1 |
Others | Others |
TNCA (Lycoperodine-1) 是一种具有共激动剂活性的高亲和力 CaSR 配体 (CaSRL)。 | |||
T6333 |
MM-102
MM102,HMTase Inhibitor IX |
Histone Methyltransferase | Chromatin/Epigenetic |
MM-102 (HMTase Inhibitor IX) 是一种有效的 WDR5/MLL 相互作用抑制剂,在 WDR5 结合检测中,IC50为 2.4 nM,Ki 小于 1 nM。 | |||
T9995 |
Antituberculosis agent-5
|
Others | Others |
Antituberculosis agent-5是一种用于高通量测定的小分子。 | |||
T3497 |
Ocaperidone
奥卡哌酮,Ocaperidona,R79598 |
Dopamine Receptor; 5-HT Receptor | GPCR/G Protein; Neuroscience |
Ocaperidone (Ocaperidona) 是5-HT2和多巴胺D2的拮抗剂,也是5-HT1A 的激动剂,有安定作用。 | |||
T9994 |
WAY-620521
|
Others | Others |
WAY-620521是一种用于细胞的高通量测定小分子。 | |||
T23312 |
SB 204741
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
SB 204741 是一种选择性的5-HT2B 拮抗剂,具有高亲和性,pKi 值为7.1。 | |||
T0107 |
Halcinonide
Halcimat,Halciderm,哈西奈德,Halcinonida,氯氟舒松,SQ-18566 |
Glucocorticoid Receptor; Smo | Endocrinology/Hormones; Stem Cells |
Halcinonide (Halciderm) 是一种糖皮质激素,可用于局部皮肤感染的研究。 | |||
T4531 |
GSK2200150A
|
Antibacterial | Microbiology/Virology |
GSK2200150A 是一种通过高通量筛选活动确定的抗结核剂,对 H37Rv 的 MIC 是 0.38 μM。 | |||
T21246 |
Metsulfuron-methyl
|
Others | Others |
Metsulfuron-methyl 是一种内吸传导选择性麦田高效磺酰脲类除草剂,主要防治麦田大多数阔叶杂草和禾本科杂草。 | |||
T39573 |
GSK251
|
PI3K | PI3K/Akt/mTOR signaling |
GSK251是一种新型的,口服生物利用度高的PI3Kδ抑制剂,具有高效性和高选择性,且具有独特的结合模式。 | |||
T9755 |
MRTX0902
UNII-CRG69FR93G |
Raf | MAPK |
MRTX0902 是一种有效且高选择性的 SOS1 抑制剂,IC50 为 46 nM,Ki 为 2 nM。 | |||
T68134 |
Ro-3201195
|
p38 MAPK | MAPK |
Ro-3201195是一种新型可口服的p38 MAPK 抑制剂,具有很高的选择性。 | |||
TP1957L |
PKI (5-24) Acetate(99534-03-9 free base)
|
PKA | Tyrosine Kinase/Adaptors |
PKI (5-24) Acetate(99534-03-9 free base) 是一种高亲和力 PKA 抑制剂 (Ki = 2.3 nM)。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8465 |
28-high brassinolide
|
Others | Others |
28-high brassinolide 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 T8465,CAS号为 82373-95-3。 | |||
T3804 |
Neomangiferin
Mangiferin 7-glucoside,新芒果苷 |
Phosphatase | Metabolism |
Neomangiferin (Mangiferin 7-glucoside) 是一种天然的 C-glucosyl xanthone,分离自干燥的Anemarrhena asphodeloides 的根茎中。它能够减轻大鼠高脂饮食诱导的非酒精性脂肪性肝病 (NAFLD)。 | |||
TN1624 |
Ethyl cinnamate
|
Calcium Channel; ROS; NO Synthase | Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism |
Ethyl cinnamate 是食品香料和化妆品添加剂,也是哺乳动物组织的优良清除剂。 | |||
TN1117 |
Veraguensin
|
p38 MAPK; NF-κB; Antibiotic; Parasite; Antifection | MAPK; Microbiology/Virology; NF-κB |
Veraguensin 来源于 Magnolia sp.。 Veraguensin 抑制骨吸收并显示出高抗寄生虫活性。 | |||
T14961 |
Chrysene
䓛,屈 |
Others | Others |
Chrysene 是高分子量 (HMW) 多环芳烃,有极强的顽固性和致癌性。 | |||
T12296 |
Oleoylethanolamide
油酰单乙醇胺,N-Oleoylethanolamide,Oleamide MEA,Oleic acid monoethanolamide |
Endogenous Metabolite; PPAR | DNA Damage/DNA Repair; Metabolism |
Oleoylethanolamide (N-Oleoylethanolamide) 是一种PPAR-α 的高亲和力内源性激动剂,可用于肥胖和动脉硬化的相关研究。 | |||
T4S1951 |
10-Methoxycamptothecin
|
Others; ADC Cytotoxin | Antibody-drug Conjugate/ADC Related; Others |
10-Methoxycamptothecin 是分离自喜树的喜树碱衍生物,具有高抗癌特性。通过对 2774 细胞系的抗肿瘤活性测定,发现它比 10-羟基喜树碱的细胞毒性更高。 | |||
TMA2386 |
4,4'-Methylenediphenol
|
Others | Others |
4,4'-Methylenediphenol 首次从 Galeola Faberi 的根茎中分离出来,具有抗氧化活性。 | |||
T0532 |
5,6-Dihydro-5-methyluracil
5, 6-Dihydrothymine,二氢朐腺嘧啶,Dihydrothymine |
Nucleoside Antimetabolite/Analog; Endogenous Metabolite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Dihydrothymine 是胸腺嘧啶的中间代谢产物之一,来源于动植物,浓度过高时会产生毒性。 | |||
TQ0027 |
Transcrocetinate disodium
Disodium trans-crocetinate,藏红花,藏红花酸二钠盐 |
NMDAR; iGluR | Membrane transporter/Ion channel; Neuroscience |
Transcrocetinate disodium (Disodium trans-crocetinate) 从藏红花中提取的一种天然产物,是高亲和力NMDA 受体拮抗剂。 | |||
T22300 |
Creatine monohydrate
Methylguanidoacetic acid monohydrate,一水肌酸 |
Others; Endogenous Metabolite | Metabolism; Others |
Creatine monohydrate (Methylguanidoacetic acid monohydrate) 是磷酸原能量系统的关键参与者,尤其是在肌肉和大脑中。 Creatine monohydrate 是高强度、短期活动中 ATP 的主要来源。 | |||
TMA1570 |
Sappanone A
|
NF-κB; Nrf2 | Immunology/Inflammation; NF-κB |
Sappanone A 是一种高异黄烷酮,通过调节 Nrf2 和 NF-κB 表现出抗炎作用。Sappanone A 可以减轻卵清蛋白引起的哮喘中的过敏性气道炎症。 | |||
T0344L |
Miconazole nitrate
NSC 169434 Nitrate,硝酸咪康唑,R18134 nitrate |
Antibacterial; Antibiotic; Antifungal | Microbiology/Virology |
Miconazole nitrate (R18134 nitrate) 是咪唑类可抗菌的抗真菌剂。 | |||
T19608 |
Zinc sulfate heptahydrate
|
Others | Others |
Zinc sulfate heptahydrate 是七水合形式的硫酸锌,是一种膳食补充剂,可用于锌缺乏症和预防高危人群的锌缺乏症。 | |||
T1424 |
Ethynyl estradiol
乙炔基雌二醇,17α-Ethynylestradiol,Ethinyl Estradiol,炔雌醇 |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Ethynyl estradio 是一种高效的生物活性雌激素。 | |||
TP1232L |
Amylin, amide, rat acetate(124447-81-0,free base)
|
Amylin Receptor | GPCR/G Protein |
Amylin, amide, rat acetate(124447-81-0,free base) 是 AMY1 和 AMY3 受体以及 AMY2 受体的强效和高亲和力配体。 | |||
TN1048 |
Cnidilin
Knidilin |
||
Cnidilin (Knidilin) 存在与Angelica dahurica 根中,具有高BBB 通透性,在治疗中枢神经系统疾病方面具有药代动力学潜力。 | |||
T3878 |
Raddeanin A
NSC382873,竹节香附素A,Anemodeanin A,Raddeanin R3 |
Apoptosis; HDAC | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair |
Raddeanin A (NSC-382873) 是竹节香附中的一种天然三萜皂苷,可抑制组蛋白去乙酰化酶,具有很强的抗血管生成能力和抗肿瘤活性。 | |||
T19344 |
Glycogen, Mussel
α-1,6 葡聚糖,Glycogen |
Endogenous Metabolite | Metabolism |
Glycogen, Mussel 是一种糖酵解的中间产物和高能磷酸盐,它是人类、动物、真菌和细菌的一种能量储存形式。 | |||
T2975 |
2,3-Dimethoxybenzaldehyde
5,6-Dimethoxybenzaldehyde,邻藜芦醛,o-Veratraldehyde |
Antifungal | Microbiology/Virology |
2,3-Dimethoxybenzaldehyde (5,6-Dimethoxybenzaldehyde) 是苯甲酸类似物,具有高抗真菌活性(MIC=2.5 mM)。2,3-Dimethoxybenzaldehyde 可用于合成小檗碱。 | |||
T39887 |
(S)-3-(4-Hydroxyphenyl)lactic acid
(S)-3-(4-羟苯基)乳酸,(S)-3-(4-Hydroxyphenyl)lactic acid,(S)-3-(4-Hydroxyphenyl)-2-hydroxypropionic acid |
Others; Antioxidant | Others; oxidation-reduction |
(S)-3-(4-Hydroxyphenyl)-2-hydroxypropionic acid 是分离自间肠隐球菌培养基的代谢物,具有高的 DPPH 清除自由基活性和抗氧化活性。 | |||
TN1049 |
Ingenol-5,20-acetonide
|
Others | Others |
Ingenol-5,20-acetonide 是一种天然化合物,Ingenol 3-Angelate的类似物,当局部用于治疗光化性角化病时具有抗肿瘤活性。 | |||
TN7241 |
Annatto
|
||
T4831 |
α,α-Dimethylglycine
2-Aminoisobutyric acid,α-Aminoisobutanoic acid,2-甲基丙氨酸 |
Others; Endogenous Metabolite | Metabolism; Others |
NSC-16590 (2-Aminoisobutyric acid) 对苍耳子叶中内源性乙烯(ethylene)的产生具有抑制作用。 | |||
TN1012 |
Febrifugine
|
IL Receptor; Anti-infection; Parasite | Immunology/Inflammation; Microbiology/Virology |
Febrifugine 是存在于常山的根和叶中的一种喹唑啉酮类生物碱,有抗疟活性。它是一种有效的抗球虫药,具有杀灭裂殖体的作用。 | |||
TN1860 |
Licoflavone B
甘草黄酮 B,甘草黄酮B |
ATPase; Anti-infection; Parasite | Membrane transporter/Ion channel; Microbiology/Virology |
Licoflavone B 是从甘草中得到的一种类黄酮,抑制曼氏血吸虫 ATPase 和 ADPase 的活性,IC50值分别为 23.78 µM 和 31.50 µM。 | |||
T3S0872 |
Paederoside
|
Antiviral; HBV | Immunology/Inflammation; Microbiology/Virology |
Paederoside 是从Paederia pertomentosa 分离的一种单萜 S-甲基硫代碳酸酯。它抑制 Epstein-Barr 病毒的激活,有抗肿瘤促进作用。 | |||
T3262 |
Phosphocreatine disodium
Disodium phosphocreatine,Phosphocreatine disodium salt,Creatine phosphate disodium salt,磷酸肌酸钠 |
Others; Endogenous Metabolite | Metabolism; Others |
Phosphocreatine disodium (Phosphocreatine disodium salt) 是一种磷酸化的肌酸分子,在肌肉、骨骼和大脑中作为一种可快速动员的高能磷酸盐储备。 | |||
T19924 |
Rhododendrol
Betuligenol,Frambinol,杜鹃醇 |
Others | Others |
Rhododendrol (Frambinol) 是一种黑色素合成物,防止雄性小鼠高脂饮食引起的体重升高和增加雄性小鼠白色脂肪细胞的脂肪分解。Rhododendrol 可用作美白/美白化妆品抑制剂。 | |||
T3976 |
Cytosporone B
Csn-B,Dothiorelone G |
Others | Others |
Cytosporone B (Dothiorelone G) 是一种天然存在的核孤儿受体Nur77/NR4A1激动剂(EC50=0.278 nM)。 | |||
T3S1692 |
Octahydrocurcumin
|
Anti-infection; NF-κB; Reactive Oxygen Species; ROS | Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB |
Octahydrocurcumin 是一种姜黄素的氢化衍生物,是姜黄素的代谢物。 | |||
TN3831 |
(-)-Denudatin B
Denudatin B |
ATPase; Potassium Channel; Calcium Channel; PAFR | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism |
(-)-Denudatin B (Denudatin B) 源自 Magnolia fargesii。 (-)-Denudatin B 通过抑制胶原蛋白和凝血酶诱导的磷酸肌醇分解,在高浓度下具有非特异性抗血小板作用。 | |||
T3313 |
D-Luciferin
Firefly luciferin,D-萤光素,D-荧光素,D-(-)-Luciferin |
Others | Others |
D-Luciferin (D-(-)-Luciferin) 是一种萤光素酶的底物,能够催化生物发光昆虫产生典型的黄绿光。 | |||
T21205 |
Ponasterone A
坡那甾酮A,AI3-44686 |
Others | Others |
Ponasterone A 是一种蜕皮激素,能够高度亲和蜕皮激素受体。它能够使报告基因能够快速打开和关闭,是细胞和转基因动物中基因表达的有效调节剂。 | |||
T5545 |
Maltol
Veltol,Larixinic acid,麦芽酚,Palatone |
Antioxidant; Endogenous Metabolite | Metabolism; oxidation-reduction |
Maltol 是一种在红参中高浓度存在的芳香化合物的类型,是一种有效的抗氧化剂,用于增强味道和保藏食品。 | |||
T3382 |
Wilforlide A
Abruslactone A,雷公藤内酯甲,3-Epiabruslactone A,Regelide |
Tyrosinase | Proteases/Proteasome |
Wilforlide A (3-Epiabruslactone A) 是一种具有生物活性的三萜,从雷公藤中分离得到,具有抗炎和免疫抑制活性。 | |||
T21418 |
Lisinopril
Linopril,赖诺普利,Zestril,Prinivil,Lisipril |
RAAS | Endocrinology/Hormones |
Lisinopril (Prinivil) 是一种血管紧张素转化酶抑制剂,能够作用于高血压,充血性心力衰竭和心脏病等。 | |||
TN1150 |
Procyanidin B3
原花青素B3,原花青素 B3 |
Histone Acetyltransferase | Chromatin/Epigenetic |
Procyanidin B3 是从葡萄中提取的一种黄酮类天然产物,是组蛋白乙酰转移酶特异性抑制剂,可与 p300的其他位点而非活性位点结合,选择性抑制 p300 介导的 androgen 受体乙酰化。 | |||
TN1035 |
Irisolidone
尼泊尔鸢尾异黄酮,葛花苷元 |
IL Receptor; NF-κB; Chloride channel | Immunology/Inflammation; Membrane transporter/Ion channel; NF-κB |
Irisolidone 是葛根花中的一种异黄酮,具有较强的保肝活性。它是一种有效的体积调节阴离子通道 (VRAC) 电流抑制剂,有高效阻断作用,IC50 为 5-13 μM。 | |||
T3666 |
Atractylodin
苍术素,Atractydin |
Lipid | Metabolism |
Atractylodin (Atractydin) 是一种Atractylodes lancea 和A. chinensis 的根茎中所含精油的活性成分。它是天然杀虫剂,能够抑制Tribolium castaneum 的活性。 | |||
T5081 |
Adenine monohydrochloride hemihydrate
腺嘌呤盐酸盐,Adenine hydrochloride hydrate,6-Aminopurine hydrochloride hydrate |
Endogenous Metabolite; Adenosine Receptor | GPCR/G Protein; Metabolism; Neuroscience |
Adenine monohydrochloride hemihydrate 是内源性代谢产物的一种。 | |||
T13795 |
Nicotinamide riboside
|
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Nicotinamide riboside 是维生素 B3 的来源,可以增强氧化代谢并防止高脂肪饮食诱导的代谢异常。它是具有口服活性的 NAD+的前体,增加 NAD+水平并激活SIRT1和SIRT3,可用于研究阿尔茨海默氏病的认知退化。 | |||
T8148 |
Mupirocin calcium hydrate
莫匹罗星钙,Mupirocin calcium |
Others; Antibacterial; Antibiotic | Microbiology/Virology; Others |
Mupirocin calcium hydrate 是从Pseudomonas fluorescens 中分离得到的,一种有口服活性的抗生素。它可逆地抑制异亮氨酸转移RNA,并抑制细菌蛋白和RNA 的合成起到抗菌作用。 | |||
TN1146 |
8-Prenylnaringenin
8-Prenylnaringenin,8-异戊烯基柚皮素 |
Apoptosis; ROS | Apoptosis; Immunology/Inflammation |
8-prenylnaringenin 是一种从啤酒花穗中分离到的异戊烯类黄酮,具有细胞毒性。它能通过激活小鼠 Akt 磷酸化途径,使其从静止诱导的停用性肌肉萎缩中恢复。它能通过诱导内源性和外源性通路介导的凋亡,对 HCT-116 结肠癌细胞产生抗增殖活性。 | |||
TN2031 |
γ-Terpinene
Moslene,p-Mentha-1,4-diene,Crithmene |
Antioxidant | oxidation-reduction |
γ-Terpinene (p-Mentha-1,4-diene) 是一种单萜化合物,具有高抗氧化属性,适合口服。它展示了直接的自由基清除能力,并且已知是一种有效的抗痛剂。 | |||
TN2158 |
Robinetin
3,3',4',5',7-Pentahydroxyflavone,洋槐黄素 |
Anti-infection; HIV Protease; Antibacterial | Microbiology/Virology; Proteases/Proteasome |
Robinetin (3,3',4',5',7-Pentahydroxyflavone) 是一种天然黄酮,具有显著的“两种颜色”固有荧光特性。它具有抗真菌、抗病毒、抗菌、抗突变、抗氧化和抗自由基活性,高效抑制 EYPC 膜脂质过氧化和 HbA 糖基化。 | |||
T4726 |
D-Glucose 6-phosphate sodium
G6P sodium salt,D-Glucose 6-phosphate sodium salt,D-葡萄糖-6-磷酸钠盐,Sodium Glucose-6-Phosphate |
Others; Endogenous Metabolite | Metabolism; Others |
D-Glucose 6-phosphate sodium (G6P sodium salt) 是内源性代谢产物的一种。 | |||
T5251 |
Phenylpyruvic acid
2-Oxo-3-phenylpropanoic acid,3-Phenylpyruvic acid,苯丙酮酸 |
Others; Endogenous Metabolite | Metabolism; Others |
Phenylpyruvic acid (3-Phenylpyruvic acid) 可以通过乳酸脱氢酶合成3-苯基乳酸 (PLA)。 | |||
T4785 |
Oxfenicine
4-羟基-L-苯甘氨酸,4-Hydroxy-L-phenylglycine |
Others | Others |
Oxfenicine (4-Hydroxy-L-phenylglycine) 是具有口服活性的肉碱棕榈酰转移酶-1 抑制剂。它在缺血期间保护心脏免受坏死组织的损害。它可抑制心脏中脂肪酸的氧化。 | |||
T0775 |
Coumarin
|
Factor Xa; Influenza Virus | Metabolism; Microbiology/Virology |
Coumarin 是中国北沙参中的一种主要生物活性成分,具有抗癌、抗炎和抗病毒等活性。它作为几种抗凝剂的前体具有临床价值,尤其是华法林。 | |||
------------------------ 更多 ------------------------ |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-04261 |
CD64 Protein, Human, Recombinant (His)
Fc γ RI,Fc receptor, IgG, high affinity I,Fc gamma ... |
Human | HEK293 Cells |
CD64 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32 kDa and the accession number is P12314-1. | |||
TMPY-01848 |
HMGB1 Protein, Human, Recombinant (aa 1-215, His)
SBP-1,high mobility group box 1,HMG-1,HMG3,HMG1 |
Human | HEK293 Cells |
HMGB1 Protein, Human, Recombinant (aa 1-215, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is A0A024RDR0. | |||
TMPY-01205 |
CD64 Protein, Mouse, Recombinant (His)
Fc receptor, IgG, high affinity I,IGGHAFC,AI323638,... |
Mouse | HEK293 Cells |
CD64 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32 kDa and the accession number is P26151. | |||
TMPY-02590 |
HMGB1 Protein, Mouse, Recombinant (hFc)
HMG-1,SBP-1,high mobility group box 1,p30,Hmg1,DEF,... |
Mouse | HEK293 Cells |
HMGB1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 53.3 kDa and the accession number is P63158. | |||
TMPY-03054 |
Fc epsilon RI Protein, Human, Recombinant (His)
Fc ε RI,α polypeptide,Fc fragment of IgE, high affi... |
Human | HEK293 Cells |
Fc epsilon RI Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.5 kDa and the accession number is P12319. | |||
TMPY-05084 |
Fc epsilon RI Protein, Human, Recombinant
alpha polypeptide,FcERI,α polypeptide,Fc fragment of IgE, |
Human | HEK293 Cells |
Fc epsilon RI Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 21 kDa and the accession number is P12319. | |||
TMPH-02707 |
HMGB1 Protein, Mouse, Recombinant (His)
High mobility group protein 1,Hmgb1,High m... |
Mouse | E. coli |
HMGB1 Protein, Mouse, Recombinant (His) is expressed in E. coli. | |||
TMPJ-00918 |
HMGB2 Protein, Human, Recombinant (His)
High Mobility Group Protein B2,HMG2,High M... |
Human | HEK293 Cells |
High Mobility Group Protein B2 (HMGB2) belongs to the non-histone chromosomal high-mobility group protein family. Members of this family are chromatin-associated and widely spread in the nucleus of higher eukaryotic cells. HMGB2 contains 2 HMG box DNA-binding domains. It is associated with chromatin and has the ability to bend DNA, preferentially single-stranded DNA. It is shown that HMGB2 is able to efficiently bend DNA and form DNA circles. In addition, HMGB2 is involved in the final ligation ... | |||
TMPJ-00668 |
HMGB3 Protein, Human, Recombinant (His)
HMG4,High Mobility Group Protein 2a,HMG-2a,High... |
Human | HEK293 Cells |
High Mobility Group Protein B3 (HMGB3) belongs to the HMGB family. Members of the HMG box subfamily are thought to be have an important role in DNA replication, nucleosome assembly and transcription. HMGB3 binds preferentiallly single-stranded DNA and unwinds double stranded DNA. HMGB3 consists of 200 amino acids and is localized to the cell nucleus. It contains two HMG box DNA-binding domain. HMGB3 binds preferentially single-stranded DNA and unwinds double stranded DNA. | |||
TMPY-05257 |
FCAMR/CD351 Protein, Mouse, Recombinant (His)
Fc receptor, IgA, IgM, high affinity |
Mouse | HEK293 Cells |
FCAMR/CD351 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.4 kDa and the accession number is Q2TB54-2. | |||
TMPJ-00095 |
HMGB1 Protein, Human, Recombinant (Truncated)
HMG1,HMG-1,High Mobility Group Protein B1,High<... |
Human | E. coli |
HMGB1 Protein, Human, Recombinant (Truncated) is expressed in E. coli expression system. The predicted molecular weight is 13 KDa and the accession number is P09429. | |||
TMPJ-00094 |
HMGB1 Protein, Human, Recombinant (N-teminal)
HMG1,HMGB1,High Mobility Group Protein B1,HMG-1, |
Human | E. coli |
HMGB1 Protein, Human, Recombinant (N-teminal) is expressed in E. coli expression system. The predicted molecular weight is 14 KDa and the accession number is P09429. | |||
TMPY-02015 |
CD64 Protein, Rat, Recombinant (His)
Fc receptor, IgG, high affinity I |
Rat | HEK293 Cells |
CD64 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.6 kDa and the accession number is A0A0B4J2J0. | |||
TMPH-03313 |
HMGB1 Protein, Rat, Recombinant (His)
High mobility group protein 1,Amphoterin,High |
Rat | E. coli |
HMGB1 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 30.8 kDa and the accession number is P63159. | |||
TMPY-02146 |
CD64 Protein, Human, Recombinant (His & Avi), Biotinylated
Fc γ RI,Fc receptor, IgG, high affinity I,CD64,Fc g... |
Human | HEK293 Cells |
CD64 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 34.4 kDa and the accession number is P12314-1. | |||
TMPH-02706 |
PDE9A Protein, Mouse, Recombinant (His)
High affinity cGMP-specific 3',5'-cyclic phosphodie... |
Mouse | E. coli |
PDE9A Protein, Mouse, Recombinant (His) is expressed in E. coli. | |||
TMPY-00559 |
GPIHBP1 Protein, Human, Recombinant (His)
GPI-HBP1,HYPL1D,glycosylphosphatidylinositol anchored hi... |
Human | HEK293 Cells |
GPIHBP1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.9 kDa and the accession number is Q8IV16. | |||
TMPY-00822 |
HMGB1 Protein, Human, Recombinant (hFc)
HMG1,SBP-1,high mobility group box 1,HMG3,HMG-1 |
Human | HEK293 Cells |
HMGB1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.5 kDa and the accession number is A0A024RDR0. | |||
TMPJ-01004 |
HDGF Protein, Human, Recombinant (His)
HDGF,Hepatoma-Derived Growth Factor,HMG1L2,High Mob... |
Human | E. coli |
Hepatoma-Derived Growth Factor is a original member of the HDGF family. HDGF is a cytoplasmic protein and contains one PWWP domain. HDGF expression levels are high in the nucleus and cytoplasm of smooth muscle and endothelial cells. HDGF has proliferative, angiogenic and neurotrophic activity. HDGF was initially characterized as a secreted mitogen from the Huh-7 human hepatoma cell line. As a heparin-binding protein, which is highly expressed in tumor cells where it stimulates proliferation. HDG... | |||
TMPH-01467 |
PDE9A Protein, Human, Recombinant (His & Myc)
PDE9A,High affinity cGMP-specific 3',5'-cyclic phos... |
Human | E. coli |
PDE9A Protein, Human, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPY-00557 |
GPIHBP1 Protein, Human, Recombinant (hFc)
glycosylphosphatidylinositol anchored high density ... |
Human | HEK293 Cells |
GPIHBP1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.2 kDa and the accession number is Q8IV16. | |||
TMPY-02979 |
HMGN3 Protein, Human, Recombinant (His)
PNAS-24,TRIP7,PNAS-25,high mobility group nucleosom... |
Human | E. coli |
HMGN3 belongs to the HMGN family and is expressed in the kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate, and uterus. Members of the HMGN family bind to nucleosomes without any specificity for the underlying DNA sequence. They affect the global and local structure of chromatin, as well as the levels of histone modifications, and thus play a role in epigenetic regulation of gene expression. HMGN3 regulates the expression of the glucose transporter ... | |||
TMPY-03427 |
HMGB1 Protein, Human, Recombinant (aa 57-158, His)
SBP-1,HMG3,high mobility group box 1,HMG1,HMG-1 |
Human | E. coli |
HMGB1 Protein, Human, Recombinant (aa 57-158, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 13.6 kDa and the accession number is P09429. | |||
TMPH-00189 |
HtpG Protein, Bacteroides fragilis, Recombinant (His & Myc & SUMO)
Chaperone protein HtpG,Heat shock protein HtpG,htpG,High... |
Bacteroides fragilis | E. coli |
Molecular chaperone. Has ATPase activity. HtpG Protein, Bacteroides fragilis, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 57.0 kDa and the accession number is Q5LCH4. | |||
TMPH-02939 |
TFAM Protein, Mouse, Recombinant (His & Myc)
Testis-specific high mobility group protein,Transcr... |
Mouse | E. coli |
TFAM Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 30.9 kDa and the accession number is P40630. | |||
TMPH-03027 |
HMW1 Protein, Mycoplasma pneumoniae, Recombinant (His & Myc)
Cytadherence accessory protein 1,Cytadherence high ... |
Mycoplasma pneumoniae | E. coli |
Component of the cytoskeleton-like structure which stabilizes the shape of the wall-less Mycoplasma. This cytoskeleton-like network of accessory proteins containing HMW proteins 1 to 5 allows the proper anchoring of cytadhesin proteins in the mycoplasmal membrane at the attachment organelle. | |||
TMPY-01988 |
CD64 Protein, Mouse, Recombinant (His & Avi), Biotinylated
Fc receptor, IgG, high affinity I,FcgammaRI,CD64,IG... |
Mouse | HEK293 Cells |
CD64 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 34.3 kDa and the accession number is P26151. | |||
TMPH-03028 |
HMW3 Protein, Mycoplasma pneumoniae, Recombinant (His & Myc)
hmw3,Accessory adhesin protein 3,Cytadherence accessory prot... |
Mycoplasma pneumoniae | E. coli |
Component of the cytoskeleton-like structure which stabilizes the shape of the wall-less mycoplasma. This cytoskeleton-like network of accessory proteins containing HMW proteins 1 to 5 allows the proper anchoring of cytadhesin proteins in the mycoplasmal membrane at the attachment organelle. Essential for successful surface parasitism. HMW3 Protein, Mycoplasma pneumoniae, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight... | |||
TMPH-00594 |
HtpG Protein, E. coli, Recombinant (His)
Chaperone protein HtpG,Heat shock protein C62.5,Heat shock p... |
E. coli | E. coli |
Molecular chaperone. Has ATPase activity. | |||
TMPH-02894 |
HTRA1 Protein, Mouse, Recombinant (His)
Serine protease 11,Serine protease HTRA1,Htra1,High... |
Mouse | E. coli |
HTRA1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 39.0 kDa and the accession number is Q9R118. | |||
TMPH-02081 |
HTRA1 Protein, Human, Recombinant (His & SUMO)
Serine protease HTRA1,HTRA1,Serine protease 11,L56,High<... |
Human | E. coli |
HTRA1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPH-01776 |
HMGN2 Protein, Human, Recombinant (GST)
Non-histone chromosomal protein HMG-17,HMGN2,High m... |
Human | E. coli |
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. HMGN2 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 36.4 kDa and the accession number is P05204. | |||
TMPH-01468 |
SLC31A1 Protein, Human, Recombinant (His & SUMO)
Copper transporter 1,SLC31A1,High affinity copper u... |
Human | E. coli |
SLC31A1 Protein, Human, Recombinant (His & SUMO) is expressed in in vitro E. coli expression system. | |||
TMPH-00595 |
HtpG Protein, E. coli, Recombinant
High temperature protein G,Heat shock protein C62.5... |
E. coli | E. coli |
Molecular chaperone. Has ATPase activity. | |||
TMPY-03064 |
Fc epsilon RI Protein, Mouse, Recombinant (hFc)
α polypeptide,FcERI,Fc ε RI,Fcr-5,alpha polypeptide,Fce1a,Fc... |
Mouse | HEK293 Cells |
Fc epsilon RI Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48 kDa and the accession number is P20489. | |||
TMPJ-00326 |
CD122/IL2RB Protein, Human, Recombinant (aa 27-239, His & Avi), Biotinylated
IL-2R subunit beta,High affinity IL-2 receptor subu... |
Human | HEK293 Cells |
Human IL-2RB, also known asinterleukin-2 receptor subunit beta,is the receptor for interleukin-2. IL2 receptor complex is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. IL2 receptor complex has three forms with respect to ability to bind IL2. IL-2RB is belonged to a type I membrane protein,and has a 26 residue signal peptide, a 214 residue extracellular region, a 25 residue transmembrane region and a 286 residue cytoplasmic domain. IL-2RB is the subunit c... | |||
TMPJ-00734 |
KNG1 Protein, Human, Recombinant (His)
KNG1,High Molecular Weight Kininogen,BDK,HMWK,KNG,W... |
Human | HEK293 Cells |
Kininogen-1 is a secreted protein which contains three cystatin domains. There are two alternatively spliced forms, designated as the high molecular weight (HMW) and low MW (LMW) forms. Kininogen-1 plays a critical role in blood coagulation and inflammatory response. Kininogens are inhibitors of thiol proteases. Kininogen-1 participates in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII, also inhibits the thrombin- and plasmin-induced aggregation... | |||
TMPH-01709 |
Mucin-5B/MUC5B Protein, Human, Recombinant (His & Myc)
Mucin-5 subtype B, tracheobronchial,Mucin-5B,Sublingual glan... |
Human | E. coli |
Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus. Mucin-5B/MUC5B Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 18.9 kDa and the accession number is Q9HC84. | |||
TMPJ-00617 |
IL-33 Protein, Rhesus macaque, Recombinant (His)
Interleukin-33,IL1F11,IL33,白介素,白细胞介素,IL-1F11,Interleukin-1 F... |
Rhesus | E. coli |
Interleukin-33 (IL-33) belongs to the IL-1 superfamily. IL33 is highly expressed in endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes, but almost undetectable in placenta. IL33 induces the production of T helper-2 (Th2)-associated cytokines. IL-33 is a cytokine that mediates its biological effects by binding to and signals through IL1RL1/ST2 and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-κB and MAP kinase signaling pathways... | |||
TMPJ-01019 |
NHP2L1 Protein, Human, Recombinant (His)
High Mobility Group-Like Nuclear Protein 2 Homolog ... |
Human | E. coli |
NHP2-Like Protein 1 (NHP2L1) is a member of the ribosomal protein L7Ae family. NHP2L1 proteinis limited to the nucleus, primarily focused in the dense fibrillar component of the nucleolus. NHP2L1 has been shown to interact with RAD17and PRPF31. The protein undergoes a conformational change upon RNA-binding. NHP2L1 binds to the 5-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly, prior to step I of splicing catalysis. | |||
TMPY-05033 |
5T4/TPBG Protein, Human, Recombinant (aa 60-345, His)
5T4AG,trophoblast glycoprotein,WAIF1,M6P1,5T4 |
Human | HEK293 Cells |
Trophoblast glycoprotein (TPBG), also known as 5T4, is the therapeutic target of several anticancer agents currently in clinical development, largely due to its high expression in tumors and low expression in normal adult tissues. 5T4/TPBG Protein, Human, Recombinant (aa 60-345, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 33.1 kDa and the accession number is Q13641. | |||
TMPY-00021 |
PADI4 Protein, Human, Recombinant (His)
PADI5,PAD4,PDI4,peptidyl arginine deiminase, type IV,PAD,PDI... |
Human | Baculovirus Insect Cells |
Protein-arginine deiminase type-4, also known as HL-6 PAD, Peptidylarginine deiminase IV, Protein-arginine deiminase type I V and PADI4, is a cytoplasm and nucleus protein that belongs to the protein arginine deiminase family. PADI4 is expressed in CD34+stem cells in normal tissues, and many more CD34+ cells expressing PADI4 are present in tumour tissues. PADI4 post-translationally converts peptidylarginine to citrulline, a process called citrullination. Studies have demonstrated the high expres... | |||
TMPK-01414 |
Qa-1b&B2M&Qdm (AMAPRTLLL) Monomer Protein, Mouse, MHC (His & Avi)
Qa-1b,Qdm,MHC,H2-T23 |
Mouse | HEK293 Cells |
Qa-1b binds a peptide (AMAPRTLLL), referred to as Qdm (for Qa-1 determinant modifier), derived from the signal sequence of murine class Ia molecules. This peptide binds with high affinity and accounts for almost all of the peptides associated with this molecule. Human histocompatibility leukocyte antigen (HLA)-E, a homologue of Qa-1b, binds similar peptides derived from human class Ia molecules and interacts with CD94/NKG2 receptors on natural killer cells. | |||
TMPK-01074 |
CD163 Protein, Human, Recombinant (His & Avi)
CD163,HbSR,RM3/1,MM130,CD163 molecule,GHI/61,sCD163,SCARI1,M... |
Human | HEK293 Cells |
The hemoglobin (Hb) scavenger receptor, CD163, is a macrophage-specific protein and the upregulated expression of this receptor is one of the major changes in the macrophage switch to alternative activated phenotypes in inflammation. Accordingly, a high CD163 expression in macrophages is a characteristic of tissues responding to inflammation. CD163 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 111.4 kDa and th... | |||
TMPY-04722 |
DcR1/TRAILR3 Protein, Human, Recombinant (His)
TRAILR3,TRID,DCR1,TRAIL-R3,CD263,DCR1-TNFR,tumor necrosis fa... |
Human | HEK293 Cells |
TNFRSF10C CNV in patients with CRC is associated with distant metastatic disease. A high frequency of CGI methylation in the TNFRSF10C promoter results in inactivation of the gene and enhancement of tumor growth in most PC cell lines (except CFPAC-1). Inactivation of TNFRSF10C by CpG island (CGI) hypermethylation can play an important role in PC progression and be potentially useful as a diagnostic marker and a new therapeutic approach for PC. | |||
TMPJ-01099 |
IL-15RA Protein, Human, Recombinant (hFc, Human Cells)
interleukin-15 receptor subunit α,IL15RA,interleukin-15 rece... |
Human | HEK293 Cells |
Interleukin 15 Receptor alpha (IL-15Rα) is a transmembrane glycoprotein that plays a pleiotropic role in immune development and function, including the positive maintenance of lymphocyte homeostasis. IL-15Rα chain can bind soluble IL-15 and “transpresent” cytokine to the cells, allowing them to respond to IL-15. Soluble IL-15Rα can function as a specific high-affinity IL-15 antagonist. The soluble IL-15/IL-15Rα complexes exhibit a strong agonistic activity which is mediated through membrane-boun... | |||
TMPJ-01461 |
IL-15RA & IL-15 Protein, Human, Recombinant (hFc)
IL-15 Receptor α & IL-15 Fusion Protein,Interleukin-15,IL15R... |
Human | HEK293 Cells |
IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 ... | |||
TMPY-03958 |
TGF alpha Protein, Human, Recombinant
transforming growth factor α,转化生长因子,transforming growth fact... |
Human | E. coli |
The miR-137 served as a tumor suppressor in non-small cell lung cancer (NSCLC) and its suppressive effect is mediated by repressing TGFA expression. TGFA gene expression was significantly higher in tumor tissues compared to adjacent normal tissue and high TGFA gene expression strongly correlated with poor survival in patients with lung adenocarcinoma, and miR-374a suppresses lung adenocarcinoma cell proliferation and invasion via targeting TGFA gene expression. Transforming growth factor alpha (... | |||
TMPJ-00135 |
BDNF Protein, Human/Murine/Rat, Recombinant
BDNF,Abrineurin,Brain-Derived Neurotrophic Factor |
Human,Mouse,Rat | E. coli |
Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF, NT-3 and NT-4, BDNF binds with high affinity to the TrkB kinase receptor. It also binds with the LNGFR (for low-affinity nerve growth factor receptor, also known as p75). BDNF promotes the survival, growth and differentiation of neurons. It serves as a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. ... | |||
TMPJ-00254 |
TGF beta 3 Protein, Human/Mouse/Rat, Recombinant
Latency-associated peptide,TGF-beta-3,Transforming growth fa... |
Human,Mouse,Rat | HEK293 Cells |
Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subset ofintegrins. It binds with high affinity to TGF- β RII, a type II serine/threonine kinase receptor. TGFB3 is involved incell differentiation, embryogenesis and development.It is believed to regu... | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12300 |
Olmesartan-d4
RNH-6270 D4,奥美沙坦 D4 |
Others | Others |
Olmesartan D4 is the deuterium labeled Olmesartan. Olmesartan is an antagonist of angiotensin II receptor (AT1R) used to treat high blood pressure. | |||
T71306 |
Gemfibrozil-d6
|
||
Gemfibrozil-d6 is intended for use as an internal standard for the quantification of gemfibrozil by GC- or LC-MS. Gemfibrozil is a peroxisome proliferator-activated reporter α and PPARγ agonist. In vivo, gemfibrozil reduces serum total cholesterol, triglyceride, and LDL levels in a rat model of high-cholesterol diet-induced hyperlipidemia. Gemfibrozil reduces atherosclerotic plaque area, superoxide production, and expression of the genes encoding the NF-κB subunit p65 and chemokine (C-C) motif l... | |||
T13282 |
Valsartan-d9
CGP-48933 D9,缬沙坦 D9 |
Others | Others |
Valsartan D9 is a deuterium-labeled valsartan. Valsartan is an antagonist of the angiotensin II receptor and for the treatment of high blood pressure and heart failure. | |||
TMIJ-0389 |
Chrysene-d12
|
||
Chrysene-d12 是 Chrysene 的氘代化合物。Chrysene 的 CAS 号为 218-01-9。Chrysene 是高分子量 (HMW) 多环芳烃,有极强的顽固性和致癌性。 | |||
TMIJ-0173 |
Calcipotriol-d4
|
||
Calcipotriol-d4 是 Calcipotriol 的氘代化合物。Calcipotriol 的 CAS 号为 112965-21-6。Calcipotriol 是一种合成的 VitD3类似物,对维他命D受体具有高亲和力。 | |||
TMIJ-0183 |
Terazosin-d8
|
||
Terazosin-d8 是 Terazosin 的氘代化合物。Terazosin 的 CAS 号为 63590-64-7。 | |||
TMIJ-0498 |
Fluticasone Propionate-d5
|
||
Fluticasone Propionate-d5 是 Fluticasone Propionate 的氘代化合物。Fluticasone Propionate 的 CAS 号为 80474-14-2。Fluticasone propionate 是一种选择性糖皮质激素受体激动剂,是一种局部抗炎激素,绝对亲和力KD为 0.5 nM。具有抗病毒活性。 | |||
TMIJ-0296 |
Bezafibrate-d6 (dimethyl-d6)
|
||
Bezafibrate-d6 (dimethyl-d6) 是 Bezafibrate 的氘代化合物。Bezafibrate 的 CAS 号为 41859-67-0。Bezafibrate 是一种降血脂剂,是PPAR的激动剂,对人以及鼠PPARα、PPARγ和PPARδ的EC50分别为 50、60和20 μM, 以及 90、55 和110 μM。 | |||
T35697 |
Lauric Acid-13C
|
||
Lauric acid-13C is intended for use as an internal standard for the quantification of lauric acid by GC- or LC-MS. Lauric acid is a medium-chain saturated fatty acid. It has been found at high levels in coconut oil.1Lauric acid induces the activation of NF-κB and the expression of COX-2, inducible nitric oxide synthase (iNOS), and IL-1α in RAW 264.7 cells when used at a concentration of 25 μM.2 | |||
TMID-0139 |
17α-Ethynylestradiol-2,4,16,16-d4
|
||
17α-Ethynylestradiol-2,4,16,16-d4 是 17α-Ethynylestradiol 的氘代化合物。17α-Ethynylestradiol 的 CAS 号为 57-63-6。Ethynyl Estradiol 是一种高效的生物活性雌激素。 | |||
TMIH-0461 |
Prucalopride-13C-d3
|
||
Prucalopride-13C-d3 是 Prucalopride 的 13C 和氘代化合物。Prucalopride 的 CAS 号为 179474-81-8。Prucalopride 是一种选择性、高亲和力的 5-HT4A/4B 受体激动剂,Ki为2.5和 8 nM。它对 5-HT4A/4B 受体的选择性是其他 5-HT 受体亚型的 290 倍以上。 | |||
TMIJ-0055 |
DL-Norepinephrine-d6 HCl
|
||
DL-Norepinephrine-d6 HCl 是 DL-NorepinephrineHCl 的氘代化合物。DL-NorepinephrineHCl 的 CAS 号为 55-27-6。DL-Norepinephrine hydrochloride 是一种靶向α1 adrenoceptor和β1 adrenoceptor的神经递质,可降低心内膜下氧分压。它是一种模拟内源性去甲肾上腺素的拟交感神经作用的合成苯乙胺。 | |||
TMIJ-0042 |
Metoprolol-d7 Hydrochloride
|
||
Metoprolol-d7 Hydrochloride 是 Metoprolol Hydrochloride 的氘代化合物。Metoprolol Hydrochloride 的 CAS 号为 56392-18-8。Metoprolol 是一种选择性 β1 受体阻滞剂。Metoprolol 用于治疗高血压、因心脏血流不畅而引起的胸痛以及许多心率异常快的疾病。 | |||
TMIJ-0371 |
Coumarin-d4
|
||
Coumarin-d4 是 Coumarin 的氘代化合物。Coumarin 的 CAS 号为 91-64-5。Coumarin 是中国北沙参中的一种主要生物活性成分,具有抗癌、抗炎和抗病毒等活性。它作为几种抗凝剂的前体具有临床价值,尤其是华法林。 | |||
T70990 |
ADMA-d6
|
||
NG,NG-dimethyl-L-arginine-d6 (ADMA-d6) (hydrochloride) is intended for use as an internal standard for the quantification of NG,NG-dimethyl-L-arginine by GC- or LC-MS. ADMA is an endogenous inhibitor of nitric oxide synthase (NOS). It is formed from arginine by protein arginine methyltransferases (PRMTs) and degraded by dimethylarginine dimethylaminohydrolases (DDAHs) and alanine-glyoxylate aminotransferase 2 (AGXT2). ADMA levels are increased concomitant with an increase in blood pressure in Da... | |||
TMIJ-0050 |
Butyricacid-d7
|
||
Butyricacid-d7 是 Butyricacid 的氘代化合物。Butyricacid 的 CAS 号为 107-92-6。Butyric acid 是一种从许多乳制品中分离出来的脂肪酸,具有抗癌活性。 它抑制组蛋白去乙酰化酶 (HDAC) 并诱导胶质瘤细胞凋亡和 G1 期细胞周期停滞。此外,它在低剂量时刺激上皮细胞增殖,在高剂量时抑制增殖。 | |||
TMID-0097 |
Ethyl-d5-malonic Acid
|
||
Ethyl-d5-malonic Acid 是 Ethyl-malonic Acid 的氘代化合物。Ethyl-malonic Acid 的 CAS 号为 601-75-2。Ethylmalonic acid 是潜在有毒物质,非致癌性,与神经性厌食和甲氧基脱羧酶缺乏症有关。 | |||
T69600 |
Spermidine-d6
|
||
Spermidine-d6 is intended for use as an internal standard for the quantification of spermidine by GC- or LC-MS. Spermidine is an endogenous polyamine. It is formed from putrescine by spermidine synthase. Spermidine (25 µM) inhibits the activity of the human inward-rectifying potassium channel Kir2.3 in a patch-clamp assay. It induces autophagy in HeLa cells when used at a concentration of 100 µM and increases the lifespan of D. melanogaster, yeast, and C. elegans. Spermidine (30 mM in the drinki... | |||
T35591 |
Guanfacine-13C,15N3
Guanfacine-13C,15N3 |
||
Guanfacine-13C,15N3is intended for us as an internal standard for the quantification of guanfacine by GC- or LC-MS. Guanfacine is an α2-adrenergic receptor (α2-AR) agonist with Kivalues of 93, 1,380, and 3,890 nM for α2A-, α2B-, and α2C-ARs, respectively, in a radioligand binding assay.1It has EC50values of 52, 288, and 602 nM for α2A-, α2B-, and α2C-ARs, respectively, for stimulated [35S]GTPγS binding. It also binds to imidazoline receptor 1 (Ki= 19 nM in a radioligand binding assay).2Guanfacin... | |||
T38297 |
Ribavirin-13C5
Ribavirin-13C5 |
||
Ribavirin-13C5is intended for use as an internal standard for the quantification of ribavirin by GC- or LC-MS. Ribavirin is an antiviral guanosine nucleoside analog.1,2Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 μg/ml).3Ribavirin also reduces replication of severe acute respiratory syndrome coro... |