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TMPH-01573
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KRT35 Protein, Human, Recombinant (His & SUMO)
Keratin, type I cuticular Ha5,Keratin-35,Hair kerat...
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Human
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E. coli
|
|
N/A. KRT35 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 66.4 kDa and the accession number is Q92764. |
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TMPH-01571
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KRT34 Protein, Human, Recombinant (hFc)
Hair keratin, type I Ha4,Keratin-34,KRT34,Keratin, ...
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Human
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HEK293 Cells
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|
N/A. KRT34 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFC tag. The predicted molecular weight is 78.3 kDa and the accession number is O76011. |
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TMPH-01572
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KRT34 Protein, Human, Recombinant (His & Myc)
KRT34,Keratin-34,Hair keratin, type I Ha4,Keratin, ...
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Human
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E. coli
|
|
KRT34 Protein, Human, Recombinant (His & Myc) is expressed in E. coli. |
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TMPH-01574
|
KRT38 Protein, Human, Recombinant (His & SUMO)
Keratin, type I cuticular Ha8,KRT38,Hair keratin, t...
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Human
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E. coli
|
|
KRT38 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. |
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TMPH-01581
|
KRT1 Protein, Human, Recombinant (His)
Keratin, type II cytoskeletal 1,67 kDa cytokeratin,Keratin-1...
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Human
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E. coli
|
|
May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK. KRT1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 69.9 kDa and the accession number is P04264. |
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TMPH-01335
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FGF-5 Protein, Human, Recombinant (GST & His & Myc)
Smag-82,FGF5,Fibroblast growth factor 5,Heparin-binding grow...
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Human
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E. coli
|
|
Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase. FGF-5 Protein, Human, Recombinant (GST & His & Myc) is expressed in E. coli expression system with N-10xHis-GST and C-Myc tag. The predicted molecular weight is 62.4 kDa and the ... |
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TMPH-02654
|
FGF-5 Protein, Mouse, Recombinant (His)
Fgf5,Heparin-binding growth factor 5,Fibroblast growth facto...
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Mouse
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E. coli
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Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase. FGF-5 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 32.8 kDa and the accession number is P15656. |
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TMPH-02831
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PLET1 Protein, Mouse, Recombinant (His & SUMO)
Plet1,Placenta-expressed transcript 1 protein,Antigen mAgK11...
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Mouse
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E. coli
|
|
Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle. |
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TMPH-02830
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PLET1 Protein, Mouse, Recombinant (His)
Plet1,Placenta-expressed transcript 1 protein,Antigen mAgK11...
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Mouse
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Baculovirus Insect Cells
|
|
Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle. |
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TMPH-01865
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PLET1 Protein, Human, Recombinant (His)
PLET1,Placenta-expressed transcript 1 protein
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Human
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E. coli
|
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Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle. PLET1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 24.4 kDa and the accession number is Q6UQ28. |
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TMPH-01866
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PLET1 Protein, Human, Recombinant (His & Myc)
Placenta-expressed transcript 1 protein,PLET1
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Human
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Baculovirus Insect Cells
|
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Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle. PLET1 Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 22.3 kDa and the accession number is Q6UQ28. |
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TMPH-02670
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Gasdermin-A3 Protein, Mouse, Recombinant (His)
Gsdma3,Gasdermin-3,Gasdermin-A3
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Mouse
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E. coli
|
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Precursor of a pore-forming protein involved in the transition from catagen to telogen at the end of hair follicle morphogenesis. This form constitutes the precursor of the pore: upon cleavage, the released N-terminal moiety (Gasdermin-A3, N-terminal) binds to membranes and forms pores, triggering cell death.; Pore-forming protein that causes membrane permeabilization and pyroptosis. Released upon cleavage in vitro of genetically engineered Gsdma3, and binds to membrane inner leaflet lipids. Hom... |
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TMPY-03225
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VSIG8 Protein, Human, Recombinant (hFc)
C1orf204,V-set and immunoglobulin domain containing 8
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Human
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HEK293 Cells
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V-set and immunoglobulin domain containing 8 (VSIG8) is essential in hair cycle, oral mucosa, and the nail matrix. Moreover, VSIG8 also has an important role in proper epithelial differentiation and function in the upper alimentary tract. |
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TMPJ-01211
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EDA2R Protein, Mouse, Recombinant (His)
EDA-A2R,Tumor necrosis factor receptor superfamily member XE...
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Mouse
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HEK293 Cells
|
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Tumor necrosis factor receptor superfamily member 27, also known as XEDAR and EDA2R, is a type III transmembrane protein of the TNFR superfamily. EDA2R consists of extracellular domain (ECD) with 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. EDA2R is widely expressed, notably in embryonic basal epidermal cells and maturing hair follicles. Even though it does not contain a cytoplasmic death domain, EDA2R can associate with Fas and induce EDA‑A2 ... |
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TMPK-01193
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GPRC5D Protein-VLP, Mouse, Recombinant
MGC129713,orphan G-protein coupled receptor,GPRC5D,MGC129714
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Mouse
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HEK293 Cells
|
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Chimeric antigen receptor (CAR) T cells, a type of cell-based immunotherapy, have shown some promising results in multiple myeloma, a bone marrow cancer.The orphan G protein–coupled receptor, class C group 5 member D (GPRC5D), normally expressed only in the hair follicle, Using quantitative immunofluorescence, we determined that GPRC5D protein is expressed on CD138 MM cells from primary marrow samples with a distribution that was similar to, but independent of, BCMA. GPRC5D Protein-VLP, Mouse, R... |
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TMPK-00737
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EVA-1/MPZL2 Protein, Human, Recombinant (hFc)
Eva,Mpzl2,EVA-1,EVA 1,EVA1,Epithelial V-like antigen 1
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Human
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HEK293 Cells
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|
MPZL2 encodes myelin protein zero-like 2, an adhesion molecule that mediates epithelial cell-cell interactions in several (developing) tissues.Deleterious variants of Mplz2/MPZL2 affect adhesion of the inner-ear epithelium and result in loss of structural integrity of the organ of Corti and progressive degeneration of hair cells, supporting cells, and spiral ganglion neurons. EVA-1/MPZL2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecu... |
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TMPK-00738
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EVA-1/MPZL2 Protein, Mouse, Recombinant (hFc)
EVA 1,Mpzl2,Epithelial V-like antigen 1,EVA-1,Eva,EVA1
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Mouse
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HEK293 Cells
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MPZL2 encodes myelin protein zero-like 2, an adhesion molecule that mediates epithelial cell-cell interactions in several (developing) tissues.Deleterious variants of Mplz2/MPZL2 affect adhesion of the inner-ear epithelium and result in loss of structural integrity of the organ of Corti and progressive degeneration of hair cells, supporting cells, and spiral ganglion neurons. EVA-1/MPZL2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecu... |
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TMPJ-01370
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EDAR Protein, Mouse, Recombinant (hFc)
Ectodysplasin-A receptor,Anhidrotic ectodysplasin receptor 1...
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Mouse
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HEK293 Cells
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Ectodysplasin A receptor (EDAR) is a type I transmembrane protein of the TNF-α receptor superfamily which plays a key role in ectodermal differentiation. EDAR was encoded by the mouse downless gene and defective in human dominant and recessive forms of autosomal hypohidrotic ectodermal dysplasia (EDA) syndrome. The extracellular domain of EDAR contains 14 cysteine residues, six of which approximate the TNFRSF cysteine-rich region, the cytoplasmic domain contains a region with homology to the dea... |
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TMPH-02244
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Trichohyalin Protein, Human, Recombinant (His & Myc)
TCHH,Trichohyalin
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Human
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E. coli
|
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Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing dur... |
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TMPY-03046
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APCDD1 Protein, Human, Recombinant (hFc)
HYPT1,B7323,adenomatosis polyposis coli down-regulated 1,HTS...
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Human
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HEK293 Cells
|
|
Osteosarcoma (OS) is the most common type of bone tumor in children and adults. The expression of APCDD1, a Wnt antagonist, was reduced in OS tissues and cells compared to adjacent normal tissue and osteoblast cells, respectively. Mechanistically, this was due to increased levels of methylation in the promoter region of the APCDD1 gene. Consistently, the DNA methyltransferase inhibitor 5-AZA-dC, reduced DNA methylation in the APCDD1 promoter, and restored APCDD1 expression in OS tissue and cells... |
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TMPY-04561
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SGK3 Protein, Human, Recombinant (His & GST)
serum/glucocorticoid regulated kinase family, member 3,SGK2,...
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Human
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Baculovirus Insect Cells
|
|
Serine / threonine-protein kinase Sgk3, also known as Serum / glucocorticoid-regulated kinase 3, Serum / glucocorticoid-regulated kinase-like and SGK3, is a cytoplasmic vesicle protein that belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. SGK3 contains one AGC-kinase C-terminal domain, one protein kinase domain and one PX (phox homology) domain. Two specific sites of SGK3, one in the kinase domain (Thr-32) and the other in the C-terminal regulatory region (Ser-486... |
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TMPK-00528
|
GPRC5D Protein-VLP, Cynomolgus, Recombinant
MGC129713,GPRC5D,MGC129714,orphan G-protein coupled receptor
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Cynomolgus
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HEK293 Cells
|
|
Chimeric antigen receptor (CAR) T cells, a type of cell-based immunotherapy, have shown some promising results in multiple myeloma, a bone marrow cancer.The orphan G protein–coupled receptor, class C group 5 member D (GPRC5D), normally expressed only in the hair follicle, Using quantitative immunofluorescence, we determined that GPRC5D protein is expressed on CD138 MM cells from primary marrow samples with a distribution that was similar to, but independent of, BCMA. GPRC5D Protein-VLP, Cynomolg... |
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TMPY-02289
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CIB2 Protein, Human, Recombinant (His)
DFNB48,calcium and integrin binding family member 2,USH1J,KI...
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Human
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E. coli
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Calcium and integrin-binding protein 2 (CIB2) belongs to a protein family with four known members, CIB1 through CIB4, which are characterized by multiple calcium-binding EF-hand domains. Sensorineural hearing loss is genetically heterogeneous. The mutations in CIB2, which encodes a calcium- and integrin-binding protein, are associated with nonsyndromic deafness (DFNB48) and Usher syndrome type 1J (USH1J). Furthermore, in zebrafish and Drosophila melanogaster, CIB2 is essential for the function a... |
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TMPH-02857
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Wnt10a Protein, Mouse, Recombinant (His & Myc)
Wnt10a,Protein Wnt-10a
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Mouse
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E. coli
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Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a role in normal ectoderm development. Required for normal tooth development. Required for normal postnatal development and maintenance of tongue papillae and sweat ducts. Required for normal proliferation of basal cells in tongue filiform papillae, plantar epithelium and sweat ducts. Required for normal expression of keratins in tongue papillae. Requir... |
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TMPY-04144
|
Kremen-1 Protein, Human, Recombinant (His)
KREMEN,KRM1,kringle containing transmembrane protein 1
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Human
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HEK293 Cells
|
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KREMEN1 (Kringle Containing Transmembrane Protein 1) is a Protein Coding gene. This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The cell surface molecule KREMEN1 is an entry receptor for coxsackievirus A1 (CV-A10). Whereas loss of KREMEN1 renders cells resistant to CV-A10 infection, KREMEN1 overexpression enhances CV-A10 binding to the cell surface and increases susceptibility... |
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TMPH-01240
|
MCM2 Protein, Human, Recombinant (His)
DNA replication licensing factor MCM2,Nuclear protein BM28,M...
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Human
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E. coli
|
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Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active ... |
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TMPY-02376
|
BNIP3L Protein, Human, Recombinant
BCL2/adenovirus E1B 19kDa interacting protein 3-like,NIX,BNI...
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Human
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E. coli
|
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The deletion of BNIP3L results in retention of mitochondria during lens fiber cell remodeling, and that deletion of BNIP3L also results in the retention of endoplasmic reticulum and Golgi apparatus. BNIP3L localizes to the endoplasmic reticulum and Golgi apparatus of wild-type newborn mouse lenses and is contained within mitochondria, endoplasmic reticulum and Golgi apparatus isolated from adult mouse liver. As the cells become packed with keratin bundles, Bnip3L expression triggers mitophagy to... |
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TMPY-02129
|
Transglutaminase 3/TGM3 Protein, Human, Recombinant (His)
transglutaminase 3,UHS2,TGE
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Human
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Baculovirus Insect Cells
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Transglutaminases (TGase) are a family of calcium-dependent acyl-transfer enzymes ubiquitously expressed in mammalian cells and responsible for catalyzing covalent cross-links between proteins or peptides. Transglutaminase 3 (TGM3) is a member of a family of Ca2+-dependent enzymes that catalyze covalent cross-linking reactions between proteins or peptides. TGM3 isoform is widely expressed and is important for epithelial barrier formation. It is a zymogen, requiring proteolysis for activity. Calc... |
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TMPY-02495
|
p19 INK4d Protein, Human, Recombinant (GST)
p19-INK4D,INK4D,cyclin-dependent kinase inhibitor 2D (p19, i...
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Human
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E. coli
|
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Cyclin-dependent kinase inhibitor 2D(also known as CDKN2D or p19ink4d), a member of the INK4 family of cyclin-dependent kinase (CDK) inhibitors, negatively regulates the cyclin D-CDK4/6 complexes, which promote G1/S transition by phosphorylating the retinoblastoma tumor-suppressor gene product. It is clearly shown that DNA repair is the main target of p19ink4d effect and that diminished apoptosis is a downstream event. Experiments has uncovered a role of p19INK4d as a regulator of DNA-damage-ind... |
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TMPY-02242
|
Serpin B6 Protein, Human, Recombinant (His)
DKFZp686I04222,PTI,SPI3,PI-6,RP1-90J20.6,serpin peptidase in...
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Human
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Baculovirus Insect Cells
|
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SerpinB6, also known as Cytoplasmic antiproteinase, Peptidase inhibitor 6, Placental thrombin inhibitor, SERPINB6 and PI-6, is a cytoplasm protein that belongs to the serpin family and Ov-serpin subfamily. SerpinB6 / PI-6 is an inhibitor of cathepsin G, kallikrein-8 and thrombin. It may play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. SerpinB6 / PI-6 is ex... |
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TMPY-02766
|
PSPH Protein, Human, Recombinant
PSP,phosphoserine phosphatase,PSPHD
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Human
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E. coli
|
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Phosphoserine phosphatase (PSPH) belongs to a subfamily of the phosphotransferases. PSPH is the rate-limiting enzyme in l-serine biosynthesis. It has previously been found that Phosphoserine phosphatase (PSPH) plays a role in epidermal homeostasis. Phosphoserine phosphatase (PSP) catalyzes the hydrolysis of phosphoserine to serine. Phosphoserine phosphatase (PSPH) expression has been examined in human-mouse somatic cell hybrids retaining different combination of human chromosomes. Phosphoserine ... |
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TMPY-04388
|
BLK Protein, Human, Recombinant (GST)
MODY11,BLK proto-oncogene, Src family tyrosine kinase
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Human
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Baculovirus Insect Cells
|
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Tyrosine-protein kinase Blk, also known as B lymphocyte kinase, p55-Blk and BLK, is a member of theprotein kinase superfamily, Tyr protein kinase family and SRC subfamily. BLK / p55-Blk is expressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands and hair follicles. BLK / p55-Blk is a src-family protein tyrosine kinase specifically expressed in B-lineage cells of mice. The early onset of Blk expression during B-cell development in the bone marrow and... |
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TMPH-02690
|
PLA2G10 Protein, Mouse, Recombinant (His & Myc)
Pla2g10,Group X secretory phospholipase A2,Phosphatidylcholi...
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Mouse
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E. coli
|
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Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with preference for phosphatidylcholines and phosphatidylglycerols over phosphatidylethanolamines. Preferentially releases sn-2 omega-6 and omega-3 polyunsaturated fatty acyl (PUFA) chains over saturated fatty acyls. Contributes to phospholipid remodeling of very low-density lipoprotein (VLDL), low-density li... |
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