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Search Results for " hik "

Targets Recommended: Potassium Channel

15

抑制剂 & 化合物

20

天然产物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T12256	NS8593 hydrochloride NS8593 HCl	Potassium Channel	Membrane transporter/Ion channel
	NS8593 hydrochloride (NS8593 HCl) 是选择性的 SK 通道抑制剂。它可逆抑制 SK3介导的电流，Kd 值为 77 nM。它抑制所有 SK1-3亚型的 Ca2+依赖性 (在 0.5 μM Ca2+时，Kd 分别为 0.42、0.60 和 0.73 μM)，并且不影响中间电导和大电导的钙激活钾通道。
T16523L	PhiKan 083	Mdm2	Apoptosis
	PhiKan 083 是咔唑衍生物，可以稳定p53的突变体Y220C，Kd 值为 167 μM。它可用于癌症研究。
T9394	CHIKV-IN-2	Dehydrogenase	Metabolism
	CHIKV-IN-2 基孔肯雅病毒的选择性抑制剂，具有强大的细胞抗病毒活性 (EC90=270 nM) 以及能够改善肝微粒体稳定性。它能够抑制细胞靶二氢乳清酸脱氢酶的活性。
T125535	3-O-Caffeoylshikimic acid	Others	Others
	3-O-Caffeoylshikimic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125535。
T125004	Chikusetsusaponin V methyl ester	Others	Others
	Chikusetsusaponin V methyl ester 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125004。
T125224	Shikokianin	Others	Others
	Shikokianin 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125224。
T125229	Yashabushiketol	Others	Others
	Yashabushiketol 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125229，CAS号为 24192-00-5。
T126409	5-0-Galloylshikimicacid	Others	Others
	5-0-Galloylshikimicacid 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T126409，CAS号为 110082-91-2。
T123852	3,5-Di-O-galloylshikimic acid	Others	Others
	3,5-Di-O-galloylshikimic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T123852，CAS号为 95753-52-9。
T123853	3,4-Di-o-galloylshikimicacid	Others	Others
	3,4-Di-o-galloylshikimicacid 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T123853，CAS号为 95753-51-8。
T61675	CHIKV-IN-3
	CHIKV-IN-3 是一种有效的针对 CHIKV-122508和 CHIKV-6708的低通道抑制剂，其 EC50值分别为 1.55 和 0.14 μM。CHIKV-IN-3 作用于宿主细胞以干扰病毒复制。CHIKV-IN-3 表现出极小的细胞毒性 (CC50> 100 μM)。预防作用。
T16523	PhiKan 083 hydrochloride	Others	Others
	PhiKan 083 hydrochloride is a carbazole derivative. Which binds to the surface cavity and stabilizes Y220C (Kd: 167 μM). It also a relative binding affinity (Kd) of 150 μM in Ln229 cells.
T23355	Signal Enhancer Hikari	Others	Others
	Signal enhancer for use in western blotting, dot blotting and ELISA
T125228	Dihydroyashabushiketol	Others	Others
	Dihydroyashabushiketol 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125228，CAS号为 24192-01-6。
T20968	CyPPA	Potassium Channel; Dopamine Receptor	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	CyPPA 是hSK2和hSK3的阳性调节剂，其EC50值分别为 5.6 μM 和14 μM。它对 hSK1 和 hIK 通道无活性。

化合物

NS8593 hydrochloride

Cat.No: T12256

Synonym: NS8593 HCl

Target: Potassium Channel

Cat.No: T16523L

Target: Mdm2

Cat.No: T9394

Target: Dehydrogenase

3-O-Caffeoylshikimic acid

Cat.No: T125535

Target: Others

Chikusetsusaponin V methyl ester

Cat.No: T125004

Target: Others

Cat.No: T125224

Target: Others

Yashabushiketol

Cat.No: T125229

Target: Others

5-0-Galloylshikimicacid

Cat.No: T126409

Target: Others

3,5-Di-O-galloylshikimic acid

Cat.No: T123852

Target: Others

3,4-Di-o-galloylshikimicacid

Cat.No: T123853

Target: Others

Cat.No: T61675

PhiKan 083 hydrochloride

Cat.No: T16523

Target: Others

Signal Enhancer Hikari

Cat.No: T23355

Target: Others

Dihydroyashabushiketol

Cat.No: T125228

Target: Others

Cat.No: T20968

Target: Potassium Channel, Dopamine Receptor

Cat. No.	Product Name	Target	Signaling Pathways
TN1137	Isobutylshikonin	Others	Others
	Isobutylshikonin 是分离自Lithospermum canescens 毛状根培养的一种紫草素色素。
T1125	Shikonin NSC 252844,Isoarnebin 4,(+)-Shikonin,紫草素,Alkanna Red,C.I. 75535,Anchusa acid	TNF; NF-κB; Chloride channel; HIV Protease; PKM	Apoptosis; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
	Shikonin (Anchusa acid) 属于天然产物，是一种 TMEM16A 氯离子通道抑制剂 (IC50=6.5 μM) 和选择性 PKM2 抑制剂。Shikonin 具有抗肿瘤、抗炎和伤口愈合活性。
TN1440	Beta-Hydroxyisovalerylshikonin	EGFR; Tyrosine Kinases; Prostaglandin Receptor; Src; AMPK; Fatty Acid Synthase	Angiogenesis; Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; Metabolism; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Beta-hydroxyisovalerylshikonin 是分离自Lithospermium radix 的天然产物，具有抑制PTK 的作用，对 EGFR 和 v-Src 受体作用的IC50分别为 0.7 μM 和 1 μM。它对多种肿瘤细胞系均有抑制作用，可以高效诱导 NCI-H522 和 DMS114 细胞的死亡。
T5S2343	Acetylshikonin 乙酰紫草素,Acetyl shikonin	Others; P450; AChE	Metabolism; Neuroscience; Others
	Acetylshikonin 来源于紫草根，具有抗癌、抗炎作用。它是一种 AChE 抑制剂，具有很强的抗凋亡活性。它是一种非选择性的细胞色素 P450抑制剂，对所有 P450 亚型抑制的 IC50值范围为 1.4-4.0 μM。
TN2447	Isovalerylshikonin	Antibacterial	Microbiology/Virology
	Isovalerylshikonin 是太子参和紫草的天然产物。
T3863	Chikusetsusaponin IVa 竹节参皂苷IVa,Calenduloside F,竹节人参皂苷 IVA	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Chikusetsusaponin IVa (Calenduloside F) 是一种三萜皂苷中主要的活性成分，是一种蛋白激酶的激活剂，对血栓及一些代谢性疾病具有抵抗作用。
TN1238	3,4-O-Isopropylidene-shikimic acid 3,4-O-异亚丙基莽草酸,3,4-O-Isopropylidene shikimic acid	NOS; NO Synthase	Immunology/Inflammation
	3,4-O-Isopropylidene-shikimic acid (3,4-O-Isopropylidene shikimic acid) 是一种从Hypericum wightianum 中提取得到的天然产物。它具有抗炎症和抗氧化作用。
T3S2344	β,β-Dimethylacrylshikonin β,β-二甲基丙烯酰紫草素,Dimethylacrylshikonin,β, β-Dimethylacrylshikonin	ERK; HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; MAPK; Metabolism
	β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) 是一种萘醌衍生物，从 Arnebia nobilis 中提取得到。它利用 PI3K 通路诱导 eNOS、VEGF 和 HIF-1α 的表达，促进血管生成，具有抗肿瘤活性。
T2739	Shikimic Acid Shikimate,莽草酸	Others; Endogenous Metabolite	Metabolism; Others
	Shikimic Acid (Shikimate) 是一种三羟基环己烯羧酸，是在微生物和植物中发现的，芳香族氨基酸生物合成途径的关键代谢中间体。
TN1295	5-O-Caffeoylshikimic acid	IL Receptor; TNF; NO Synthase	Apoptosis; Immunology/Inflammation
	5-O-Caffeoylshikimic acid 具有抗氧化和抗炎作用，可用于非小细胞肺癌的研究。
T5S2347	Deoxyshikonin 去氧紫草素,Arnebin 7	Others; HIF/HIF Prolyl-Hydroxylase; Antibacterial	Chromatin/Epigenetic; Metabolism; Microbiology/Virology; Others
	Deoxyshikonin (Arnebin 7) 是从紫草中分离的天然产物，具有抗肿瘤活性，在体外具有促血管生成作用。它和没食子酸十二烷基酯在体内外均与青霉素有显着的协同抗菌活性。
TN2443	Chikusetsusaponin Ib Chikusetsu saponin Ib	AChE	Neuroscience
	Chikusetsusaponin Ib (Chikusetsu saponin Ib) 是 AChE 的抑制剂，可用于抗阿尔茨海默病的研究。
T2897	(Rac)-Shikonin (±)-Shikonin,Alkanet extract,Anchusin,紫草素,Anchusa acid	Others	Others
	(Rac)-Shikonin (Anchusin) 具有抗肿瘤作用。它能够诱导坏死死亡来绕过癌症耐药性。
T5S2350	Beta-Acetoxyisovalerylshikonin 乙酰氧基异戊酰阿卡宁,Acetoxyisovalerylalkannin,β-乙酰氧基异戊酰阿卡宁	Others	Others
	Acetoxyisovalerylshikonin 是一种萘醌衍生物，提取自Arnebia euchroma 中。
TN6458	Acetylshikonin
	Acetylshikonin can effectively inhibit tumor cells, it can be used to treat hepatocellular carcinoma cells expressing hepatitis B virus X protein (HBX) by inducing ER stress , an oncoprotein from hepatitis B virus. Acetylshikonin inhibits the production of eicosanoid, is due to the attenuation of cytosolic phospholipase A(2) membrane recruitment via the decrease in [Ca(2+)](i) and to the blockade of cyclooxygenase and 5-lipoxygenase activity.
TN3052	4-O-Caffeoylshikimic acid	Others	Others
	4-O-Caffeoylshikimic acid is a natural product from Illicium verum.
T82739	Chikusaikoside Ⅱ
	Chikusaikoside II为从Bupleurum longeradiatum提取的一种天然化合物。
TN2207	Shikonofuran A	Others	Others
	Shikonofuran A 是一种分离自 Lithosperraum erythrorhizon Sieb 的根的天然产物。
TN2439	(2-Methylbutyryl)shikonin	Others	Others
	(2-Methylbutyryl)shikonin is a natural product from Lithospermum erythrorhizon Sieb. et Zucc.
T38675	Hikizimycin Anthelmycin	Others	Others
	Hikizimycin is a potent anthelmintic and antibacterial natural product.

天然产物

Isobutylshikonin

Cat.No: TN1137

Target: Others

Cat.No: T1125

Synonym: NSC 252844,Isoarnebin 4,(+)-Shikonin,紫草素,Alkanna Red,C.I. 75535,Anchusa acid

Target: TNF, NF-κB, Chloride channel, HIV Protease, PKM

Beta-Hydroxyisovalerylshikonin

Cat.No: TN1440

Target: EGFR, Tyrosine Kinases, Prostaglandin Receptor, Src, AMPK, Fatty Acid Synthase

Cat.No: T5S2343

Synonym: 乙酰紫草素,Acetyl shikonin

Target: Others, P450, AChE

Isovalerylshikonin

Cat.No: TN2447

Target: Antibacterial

Chikusetsusaponin IVa

Cat.No: T3863

Synonym: 竹节参皂苷IVa,Calenduloside F,竹节人参皂苷 IVA

Target: AMPK

3,4-O-Isopropylidene-shikimic acid

Cat.No: TN1238

Synonym: 3,4-O-异亚丙基莽草酸,3,4-O-Isopropylidene shikimic acid

Target: NOS, NO Synthase

β,β-Dimethylacrylshikonin

Cat.No: T3S2344

Synonym: β,β-二甲基丙烯酰紫草素,Dimethylacrylshikonin,β, β-Dimethylacrylshikonin

Target: ERK, HIF/HIF Prolyl-Hydroxylase

Cat.No: T2739

Synonym: Shikimate,莽草酸

Target: Others, Endogenous Metabolite

5-O-Caffeoylshikimic acid

Cat.No: TN1295

Target: IL Receptor, TNF, NO Synthase

Cat.No: T5S2347

Synonym: 去氧紫草素,Arnebin 7

Target: Others, HIF/HIF Prolyl-Hydroxylase, Antibacterial

Chikusetsusaponin Ib

Cat.No: TN2443

Synonym: Chikusetsu saponin Ib

Target: AChE

Cat.No: T2897

Synonym: (±)-Shikonin,Alkanet extract,Anchusin,紫草素,Anchusa acid

Target: Others

Beta-Acetoxyisovalerylshikonin

Cat.No: T5S2350

Synonym: 乙酰氧基异戊酰阿卡宁,Acetoxyisovalerylalkannin,β-乙酰氧基异戊酰阿卡宁

Target: Others

Cat.No: TN6458

4-O-Caffeoylshikimic acid

Cat.No: TN3052

Target: Others

Chikusaikoside Ⅱ

Cat.No: T82739

Cat.No: TN2207

Target: Others

(2-Methylbutyryl)shikonin

Cat.No: TN2439

Target: Others

Cat.No: T38675

Synonym: Anthelmycin

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04865	Chikungunya virus (CHIKV) (strain SL-CK1) E2/Envelope 2 Protein (His)	CHIKV	Baculovirus Insect Cells
	Chikungunya virus (CHIKV) (strain SL-CK1) E2/Envelope 2 Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 39.8 kDa and the accession number is A5Y7Y5.
TMPH-03584	Shikimate dehydrogenase Protein, S. epidermidis, Recombinant (His & Myc) Shikimate dehydrogenase (NADP(+)),aroE	Staphylococcus epidermidis	E. coli
	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). It can also use NAD to oxidize shikimate. Shikimate dehydrogenase Protein, S. epidermidis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 37.4 kDa and the accession number is Q5HNV1.
TMPH-00385	Chikungunya virus (strain S27-African prototype) Non-structural protein 4 (His) P1234,Non-structural polyprotein,Polyprotein P1234	CHIKV	E. coli
	Chikungunya virus (strain S27-African prototype) Non-structural protein 4 (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.1 kDa and the accession number is Q8JUX6.

重组蛋白

Chikungunya virus (CHIKV) (strain SL-CK1) E2/Envelope 2 Protein (His)

Cat.No: TMPY-04865

Species: CHIKV

Expression System: Baculovirus Insect Cells

Shikimate dehydrogenase Protein, S. epidermidis, Recombinant (His & Myc)

Cat.No: TMPH-03584

Species: Staphylococcus epidermidis

Expression System: E. coli

Chikungunya virus (strain S27-African prototype) Non-structural protein 4 (His)

Cat.No: TMPH-00385

Species: CHIKV

Expression System: E. coli

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