25
8
19
2
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T22891 |
KL001
KL 001,KL-001 |
Others | Others |
KL001 是一流的隐花色素蛋白 (CRY)稳定剂,可与 CRY1 和 CRY2 特异性相互作用。其中CRY 是一种对蓝光敏感的黄素蛋白,参与调节动植物的昼夜节律。KL001能够防止泛素依赖性 CRY 降解,从而延长了昼夜节律周期,具有控制空腹激素诱导的糖异生的潜力。 | |||
T5045 |
GSK4112
1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate,SR6452 |
Autophagy | Autophagy |
GSK4112 (SR6452) 是一种 Rev-erbα 激动剂,EC50 为 0.4 μM。它也是一种用于核血红素受体 Rev-erbα 的细胞生物学的小分子化学探针。 | |||
T15389L |
Glucagon (1-29), bovine, human, porcine hydrochloride
盐酸胰高血糖素,Porcine glucagon hydrochloride,Glucagon hydrochloride |
Glucocorticoid Receptor; Glucagon Receptor | Endocrinology/Hormones; GPCR/G Protein |
Glucagon (1-29), bovine, human, porcine hydrochloride 是一种由胰腺 α 细胞产生的多肽激素。它可激活 HNF4α 并促进 HNF4α 磷酸化,促进糖异生。 | |||
T64345 |
4-(Dimethylamino)phenol
|
Others | Others |
4-(Dimethylamino)phenol enhances extracellular lactate dehydrogenase (LDH) levels without significant effects on gluconeogenesis. Only when the membrane becomes permeable to LDH does 4-(Dimethylamino)phenol reduce ATP content. | |||
T37185 |
D-(-)-3-Phosphoglyceric acid disodium
3-Phospho-D-glyceric acid disodium |
Others | Others |
D-(-)-3-Phosphoglyceric acid disodium (3-Phospho-D-glyceric acid disodium) 是糖酵解、糖原合成以及丝氨酸、甘氨酸、苏氨酸生物合成等过程中的重要中间体,竞争性抑制酵母烯醇化酶 (enolase)。作为中间体它还在植物、真核细胞以及原核细胞许多的生物合成信号通路中发挥许多作用。 | |||
T25572 |
Ketohypoglycin
Methylenecyclopropylpyruvate |
Others | Others |
Ketohypoglycin has been utilized to study the inhibition of gluconeogenesis in isolated rat liver cells. | |||
T69481 |
Clanobutin
|
Others | Others |
Clanobutin inhibits gluconeogenesis and acts as a choleretic and digestion-stimulating agent. | |||
T10786 |
Charantin
|
GSK-3 | PI3K/Akt/mTOR signaling; Stem Cells |
Charantin is a steroidal saponin isolated from Momordica charantia. It increases the release of insulin and slowing down gluconeogenesis. Charantin can inhibit GSK-3. | |||
T20028 |
Janumet
Efficib,Janumet XR,Metformin / sitagliptin,Metformin hydrochloride mixture with sitagliptin phosphate |
Others | Others |
Metformin hydrochloride mixture with sitagliptin phosphate is an AMP-activated protein kinase stimulant. It is also a CD26 antigen inhibitor, Gluconeogenesis inhibitor, and Glucose modulator. | |||
T70141 |
MDK80908
|
Others | Others |
MDK80908, also known as PPARalpha/gamma agonist N15, is a dual PPARα/γ agonist, ameliorating insulin resistance and gluconeogenesis in vivo and vitro. MDK80908 has CAS#1821380-90-8. | |||
T36927 |
Hydrocortisone phosphate
|
Others | Others |
Hydrocortisone phosphate is the pharmaceutical term for cortisol, which is a steroid hormone, in the glucocorticoid class of hormones, increases blood sugar through gluconeogenesis, to suppress the immune system, and to aid in the metabolism of fat, protein, and carbohydrate. | |||
T37783 |
2,5-Anhydro-D-mannitol
|
Others | Others |
2,5-Anhydro-D-mannitol is an antimetabolic fructose analogue that increases food intake in rats at doses of 50-800 mg/kg by inhibiting gluconeogenesis and glycogenolysis in the liver.. It is phosphorylated in the liver, which decreases available ATP and signals eating behavior in rats through a vagal nerve mechanism. | |||
T35265 |
YM-440
YM440,YM 440 |
Others | Others |
YM-440 is a novel hypoglycemic agent, an insulin sensitizer, that may be used for the treatment of type 2 diabetes mellitus by reducing glucose 6-phosphatase activity in obese Zucker rats and inhibiting liver glucose output through gluconeogenesis. | |||
T15389 |
Glucagon (1-29), bovine, human, porcine
胰高血糖素,Porcine glucagon,Glucagon |
Others | Others |
Glucagon is a peptide hormone, produced by pancreatic α-cells. Glucagon reduces the activity of HNF-4. Glucagon stimulates gluconeogenesis. Glucagon enhances HNF4α phosphorylation. | |||
T61992 |
SIK1 activator 1
|
Others | Others |
SIK1 activator 1可以增强SIK1磷酸化和改善2型糖尿病小鼠的高血糖状态。SIK1 activator 1显示出显著抑制肝脏糖异生的活性。 | |||
T85184 |
Glucagon hydrochloride
|
Others | Others |
Glucagon, a peptide hormone derived from proglucagon in pancreatic α cells, regulates glucose metabolism. It stimulates glucose production in rat hepatocytes ex vivo and enhances glucose output from perfused rat livers through elevated gluconeogenesis and glycogenolysis, while reducing glycolysis, and raises plasma glucose levels in rats. Glucagon secretion decreases following food intake in healthy rats and humans, yet remains unchanged or increases in individuals with type 2 diabetes. | |||
T37521 |
DL-Glyceraldehyde 3-phosphate
3-Phosphoglyceraldehyde,DL-甘油醛3-磷酸 |
Others | Others |
DL-Glyceraldehyde-3-phosphate (GADP) is an intermediate in several metabolic pathways, including glycolysis and gluconeogenesis. In glycolysis, it can be derived from fructose 1,6-bisphosphate by fructose bisphosphate aldolase in a reaction that also produces dihydroxyacetone phosphate (DHAP). Triose phosphate isomerase reversibly converts DHAP to GADP. GADP is processed to 1,3-bisphosphoglycerate by glyceraldehyde phosphate dehydrogenase and NAD+. | |||
T69380 |
Cinnamic acid, hydrazide
|
Others | Others |
Cinnamic acid, hydrazide is an unsaturated carboxylic acid and precursor to aspartame via enzyme-catalysed amination to phenylalanine. Cinnamic acid may be useful in prevention or treatment of Diabetes through various mechanism of actions including stimulation of insulin secretion, improvement of pancreatic β-cell functionality, inhibition of hepatic gluconeogenesis, enhanced glucose uptake, increased insulin signaling pathway, delay of carbohydrate digestion and glucose absorption, and inhibiti... | |||
T74941 |
D-Glyceraldehyde 3-phosphate
|
Others | Others |
D-Glyceraldehyde 3-phosphate (Triose phosphate) 是一种在生物体内广泛存在的分子,主要作为糖酵解过程和糖异生过程的关键中间体,同时也是卡尔文循环生成糖类的产物。此外,D-Glyceraldehyde 3-phosphate 还涉及色氨酸和硫胺素的生物合成过程。 | |||
T80060 |
Pyruvate carboxylase
|
Endogenous Metabolite | Metabolism |
Pyruvate carboxylase是一种催化反应中丙酮酸与HCO3−和MgATP进行依赖性羧化生成草酰乙酸的含生物素酶。它在调控肝脏糖异生、脂肪细胞脂肪酸合成及胰腺β细胞胰岛素分泌方面,对全身能量平衡发挥关键作用。 | |||
T75292 |
Biotin sodium
|
Others | Others |
Biotin (Vitamin B7) sodium 是一种水溶性维生素 B,是人体五种羧化酶的辅酶,参与脂肪酸、异亮氨酸和缬氨酸的合成,并参与糖异生。Biotin sodium 是细胞生长、脂肪酸产生以及脂肪和氨基酸代谢的必需物质。 | |||
T83814 |
8-Bromoguanosine-5'-O-triphosphate sodium
8-bromo GTP |
Others | Others |
8-Bromoguanosine-5'-O-triphosphate是一种guanosine 5'-triphosphate (GTP)的衍生物,后者是蛋白质合成和糖异生作用的能量底物。该化合物在31.8 µM的浓度下抑制大肠杆菌的GTPase FtsZ(Ki = 31.8 µM),但在500 µM的浓度下,能促进在无细胞测定中猪脑微管的组装。 | |||
T76122 |
Phosphoglycerate kinase
|
Others | Others |
Phosphoglycerate kinase(PGK),即磷酸甘油酸激酶,是一种糖酵解酶,常用于生化研究。Phosphoglycerate kinase 可以催化磷酸基团从1,3-二磷酸甘油酸(1,3-BPG)到ADP 的可逆转移,从而产生 3-磷酸甘油酸(3-PG) 和 ATP。同时也可以参与糖异生,催化相反的反应产生 1,3BPGA 和ADP。Phosphoglycerate kinase 参与了能量代谢、与核酸的相互作用、肿瘤发生进展、细胞死亡和病毒复制等相关过程。 | |||
T37120 |
1,2,3-Triundecanoyl Glycerol
|
Others | Others |
1,2,3-Triundecanoyl glycerol is a triacylglycerol that contains undecanoic acid at thesn-1,sn-2, andsn-3 positions. Dietary administration of a 7:3 (w/w) mixture of 1,2,3-triundecanoyl glycerol and corn oil prevents fasting-induced decreases in plasma glucose, alanine, and insulin levels, as well as the ratio of insulin to glucagon, in rats compared with dietary administration of corn oil alone.1 1.Pi-Sunyer, F.X., Conway, J.M., Lavau, M., et al.Glucagon, insulin, and gluconeogenesis in fasted o... | |||
T83820 |
TNP-GTP sodium
TNP-Guanosine 5'-triphosphate |
||
TNP-GTP是一种荧光衍生物,源自蛋白质合成与糖异生的能量底物鸟苷三磷酸(GTP)。其在水中激发波长为410 nm时,发射最大波长为552 nm,而在40%和80%的N,N-二甲基甲酰胺中,其荧光强度增加,发射波长分别向544 nm和532 nm移动,这是因为N,N-二甲基甲酰胺的极性比水小。TNP-GTP是谷氨酸脱氢酶的抑制剂(Ki = 2.7 μM)。当与谷氨酸脱氢酶结合时,TNP-GTP的荧光强度增加,且发射波长从552 nm变为545 nm,此效果可以通过加入GTP来阻断。TNP-GTP还是嘌呤P2X2和P2X2/3受体的拮抗剂(IC50s分别为0.4和1.2 nM)。它还选择性抑制大鼠可溶性鸟苷酸环化酶(sGC; Ki = 11 nM)高于牛肝谷氨酸脱氢酶(GDH; Ki = 2.7 µM)以及钙调素依赖的B. pertussis腺苷酸环化酶(AC)毒素(Kis在存在锰或镁时分别为20和320 µM)。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN7038 |
Regaloside H
|
Others | Others |
Regaloside H 是一种糖异生抑制剂,是一种苯丙酸甘油糖苷。它能够抑制大鼠肝癌细胞中葡萄糖的产生。 | |||
T1116 |
Biotin
Vitamin B7,生物素,D-Biotin,Vitamin H,D-生物素(维生素H) |
||
Biotin (Vitamin H) 属于天然产物,是一种 B 族维生素,具有水溶性。Biotin 参与脂肪酸产生、脂肪和氨基酸代谢以及细胞生长。Biotin 常被用于生物素标记。 | |||
T1614 |
Hydrocortisone
氢化可的松,Cortisol |
Glucocorticoid Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Hydrocortisone (Cortisol) 是一种糖皮质激素,由肾上腺素皮质分泌。Hydrocortisone 激动糖皮质激素受体,可促进蛋白质分解代谢、糖异生、毛细血管壁稳定性、肾脏钙排泄,并抑制免疫和炎症反应。 | |||
T37984 |
Fosfructose, sodium salt, hydrate (1:3:8)
D-Fructose-1,6-bisphosphate , sodium salt, hydrate (1:3:8) |
Others | Others |
D-Fructose-1,6-bisphosphate sodium salt hydrate 是碳水化合物代谢的中间体,包括糖酵解和糖异生。在糖酵解过程中,它是由磷酸果糖激酶磷酸化果糖-6-磷酸产生的。由果糖-1,6-二磷酸酶-1介导的逆反应是糖异生的限速步骤之一。同样的反应也发生在植物的叶绿体中,D-Fructose-1,6-bisphosphate sodium salt hydrate 作为还原性戊糖磷酸循环的一部分。由于癌细胞采用糖酵解作为代谢能量产生的主要来源,这一途径已成为癌症化疗的主要靶点。 | |||
T5248 |
(R)-3-Hydroxybutanoic acid
|
Others; Endogenous Metabolite | Metabolism; Others |
(R)-3-Hydroxybutanoic acid 是一种代谢物,在 3-羟基丁酸脱氢酶催化下由乙酸乙酯转化而成。它可以作为营养来源和抗生素、维生素和信息素的前体。 | |||
T3976 |
Cytosporone B
Csn-B,Dothiorelone G |
Others | Others |
Cytosporone B (Dothiorelone G) 是一种天然存在的核孤儿受体Nur77/NR4A1激动剂(EC50=0.278 nM)。 | |||
T73074 |
Phanginin A
|
Others | Others |
Phanginin A 是有效的口服活性SIK1激活剂,通过抑制糖异生、增加p-SIK1表达及降低p-CREB表达,达到降低血糖水平、改善葡萄糖耐量和血脂异常的效果,显示出其在2型糖尿病研究中的潜力。 | |||
TN4997 |
Serpentine
|
IGF-1R | Tyrosine Kinase/Adaptors |
Serpentine 是一种玫瑰花根中的生物碱,可用作胰岛素增敏剂,以协助胰岛素降低血糖。Serpentine 可激活 AMPK 磷酸化,从而刺激C2C12细胞对葡萄糖的摄取。Serpentine 可增加了肌肉组织中GSK-3β mRNA的表达,从而增强葡萄糖摄取。Serpentine 显著增加胰高血糖素分泌和肝糖异生。在高脂肪饮食/链脲佐菌素(HFD/STZ)诱导的糖尿病小鼠中,Serpentine 显著延长了胰岛素的降血糖时间,显著降低了外源性胰岛素的使用,抑制了内源性胰岛素的分泌。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-02662 |
Aldolase A Protein, Mouse, Recombinant (His)
Aldolase 1,Fructose-bisphosphate aldolase A,Muscle-type aldo... |
Mouse | Baculovirus Insect Cells |
Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein. Aldolase A Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with C-6xHis tag. The predicted molecular weight is 40.3 kDa and the accession number is P05064. | |||
TMPH-01357 |
ALDOA Protein, Human, Recombinant (His)
Muscle-type aldolase,Lung cancer antigen NY-LU-1,Fructose-bi... |
Human | E. coli |
Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein. ALDOA Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 45.3 kDa and the accession number is P04075. | |||
TMPJ-00816 |
FBPase1 Protein, Human, Recombinant (His)
D-fructose-1,FBP,6-bisphosphate 1-phosphohydrolase 1,FBPase ... |
Human | HEK293 Cells |
Fructose-1,6-bisphosphatase 1(FBP1) is a homotetramer protein and belongs to the FBPase class 1 family. It involves in carbohydrate biosynthesis; gluconeogenesis pathway. FBP1 is a gluconeogenesis regulatory protein which catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. FBP1 deficiency is associated with hypoglycemia and metabolic acidosis. FBP1 regulates mouse endogenous glucose production. FBP1 coupled with phosphofructokinase (PFK) takes p... | |||
TMPH-01390 |
G6PC Protein, Human, Recombinant (His & SUMO)
Glucose-6-phosphatase alpha,G6PC1,Glucose-6-phosphatase,Gluc... |
Human | E. coli |
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels. G6PC Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 17.1 kDa and the accession number i... | |||
TMPH-02663 |
Aldolase A Protein, Mouse, Recombinant (His & Myc)
Aldoa,Aldolase 1,Fructose-bisphosphate aldolase A,Aldo1,Musc... |
Mouse | E. coli |
Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein. Aldolase A Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 46.7 kDa and the accession number is P05064. | |||
TMPH-00911 |
GPT Protein, Human, Recombinant (His)
Glutamic--alanine transaminase 1,Glutamate pyruvate transami... |
Human | E. coli |
Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles. GPT Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 58.5 kDa and the accession number is P24298. | |||
TMPH-01389 |
G6PC Protein, Human, Recombinant (His)
Glucose-6-phosphatase,Glucose-6-phosphatase catalytic subuni... |
Human | P. pastoris (Yeast) |
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels. G6PC Protein, Human, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 5.6 kDa and the accession number is P35575. | |||
TMPH-00335 |
FBA1 Protein, Candida albicans, Recombinant (His & Myc)
Fructose-1,6-bisphosphate aldolase,IgE-binding allergen,Fruc... |
Candida albicans | E. coli |
Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. FBA1 Protein, Candida albicans, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 46.5 kDa and the accession number is Q9URB4. | |||
TMPJ-00742 |
GCG Protein, Human, Recombinant (His)
Glicentin,GRPP,GLP-2,Glucagon-Like Peptide 1,OXM,Glucagon,GL... |
Human | HEK293 Cells |
Glucagon is a secreted protein and belongs to the glucagon family. Glucagon can be cleved into 8 chains, playing an important role in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon can regulates blood glucose by decreasing glycolysis and increasing gluconeogenesis. In addition, Glucagon is involved in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon release is stimulated by hypoglycemia and inhibited by hyperglycemia, insulin, and somatostatin.... | |||
TMPH-02675 |
GCGR Protein, Mouse, Recombinant (GST)
Glucagon receptor,Gcgr |
Mouse | E. coli |
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. ... | |||
TMPH-02677 |
GPI Protein, Mouse, Recombinant (B2M & His)
Gpi,Phosphohexose isomerase,Phosphoglucose isomerase,Neurole... |
Mouse | E. coli |
In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis. Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion. | |||
TMPJ-00868 |
PFKFB1 Protein, Human, Recombinant (His)
PFKFB1,F6PK,6-P2ase liver isozyme,6-bisphosphatase 1,6PF-2-K... |
Human | HEK293 Cells |
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 is an enzyme that in humans is encoded by the PFKFB1 gene. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. It belongs to the phosphoglycerate mutase family. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activit... | |||
TMPH-02678 |
GPI Protein, Mouse, Recombinant (His)
Phosphoglucose isomerase,Autocrine motility factor,Glucose-6... |
Mouse | P. pastoris (Yeast) |
In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis. Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion. GPI Protein, Mous... | |||
TMPJ-00319 |
PFKFB3 Protein, Human, Recombinant (His)
PFK/FBPase 3,PFK2,IPFK2,iPFK-2 |
Human | E. coli |
Fructose-2,6-biphosphatase 3, also known as 6-phosphofructo-2-kinase or PFK2 or PFKFB3, involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls the activity of the enzymes phosphofructokinase 1 (PFK-1) and fructose 1,6-bisphosphatase (FBPase-1) to regulate glycolysis and gluconeogenesis. Highly phosphorylated PFKFB3 protein was found in human tumor cells, vascular endothelial cells, and smooth muscle cells. Because of its proto-oncogenic c... | |||
TMPH-01391 |
GPI Protein, Human, Recombinant (His)
Sperm antigen 36,Neuroleukin,Glucose-6-phosphate isomerase,G... |
Human | E. coli |
In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis. Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion. GPI Protein, Huma... | |||
TMPJ-00815 |
FBPase1 Protein, Human, Recombinant (His, E. coli)
6-Bisphosphate 1-Phosphohydrolase 1,FBP1,FBP,FBPase 1,D-Fruc... |
Human | E. coli |
Fructose-1,6-Bisphosphatase 1 (FBPase 1) is a member of the FBPase class 1 family. FBPase 1 is a gluconeogenesis regulatory protein, which catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. FBPase 1 can assume an active R-state, or an inactive T-state. FBPase 1 deficiency is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis in newborn infants or young chi... | |||
TMPY-01100 |
GPT2 Protein, Rat, Recombinant (His)
glutamic pyruvate transaminase (alanine aminotransferase) 2 |
Rat | Baculovirus Insect Cells |
Alanine aminotransferase (ALT), also known as glutamate pyruvate transaminase (Gpt), is a pyridoxal enzyme that catalyzes the reversible interconversion of L-alanine and 2-oxoglutalate to pyruvate and L-glutamate and plays a key role in the intermediary metabolism of glucose and amino acids. As a key enzyme for gluconeogenesis, Gpt is a widely-used serum marker for liver injury. Two ALT isoenzymes have been identified, ALT1 and ALT2 (GPT1 and GPT2), which are encoded by separate genes and share ... | |||
TMPJ-00955 |
MDH1 Protein, Human, Recombinant (His)
Cytosolic Malate Dehydrogenase,MDH1,MDHA,Diiodophenylpyruvat... |
Human | E. coli |
Malate Dehydrogenase, Cytoplasmic (MDH1) is an enzyme which belongs to the MDH Type 2 sub-family of LDH/MDH superfamily. MDH1 is involved in the Citric Acid Cycle that catalyzes the conversion of Malate into Oxaloacetate (using NAD+) and vice versa. MDH1 should not be confused with Malic Enzyme, which catalyzes the conversion of Malate to Pyruvate, producing NADPH. MDH1 also participates in Gluconeogenesis, the synthesis of Glucose from smaller molecules. Pyruvate in the mitochondria is acted up... | |||
TMPY-01099 |
GPT Protein, Rat, Recombinant (His)
Gpt1,ALAT,glutamic-pyruvate transaminase (alanine aminotrans... |
Rat | Baculovirus Insect Cells |
Alanine aminotransferase (ALT), also known as glutamate pyruvate transaminase (GPT), is a pyridoxal enzyme that belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family, Alanine aminotransferase subfamily. Gpt / Gpt1 / ALT catalyzes the reversible interconversion of L-alanine and 2-oxoglutalate to pyruvate and L-glutamate and plays a key role in the intermediary metabolism of glucose and amino acids. Gpt / Gpt1 / ALT is expressed in the liver, kidney, heart, and skeletal musc... |
Cat. No. | Product Name | Target | Signaling Pathways |
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TMIJ-0193 |
Hydrocortisone-d4
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Hydrocortisone-d4 是 Hydrocortisone 的氘代化合物。Hydrocortisone 的 CAS 号为 50-23-7。Hydrocortisone 是肾上腺皮质分泌的糖皮质激素。 | |||
TMID-0229 |
Cortisol-1,2-d2
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Cortisol-1,2-d2 是 Cortisol 的氘代化合物。Cortisol 的 CAS 号为 50-23-7。Hydrocortisone 是肾上腺皮质分泌的糖皮质激素。 |