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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T78573 |
Glucocerebrosidase
GCase,Glucosylceramidase |
Endogenous Metabolite | Metabolism |
Glucocerebrosidase (Glucosylceramidase; GBA) 是溶酶体内的酶,负责催化GC中的β-糖苷键裂解,从而生成葡萄糖和神经酰胺。 | |||
T60353 |
Glucocerebrosidase-IN-1
|
Others | Others |
Glucocerebrosidase-IN-1 (compound 11a) 是一种有效的选择性的GCase(葡糖脑苷脂酶)抑制剂,其IC50为 29.3 μM,Ki 为 18.5 μM。由于GCase 参与酶缺乏性病理疾病,Glucocerebrosidase-IN-1 可用于戈谢病 (GD) 和帕金森病 (PD) 的研究。 | |||
T78671 |
Glucocerebrosidase-IN-1 hydrochloride
|
Glucosidase | Metabolism |
Glucocerebrosidase-IN-1 (compound 11a) hydrochloride,是一种针对GCase的高效选择性抑制剂,展现出了29.3 μM的IC50和18.5 μM的Ki。该化合物适用于戈谢病(GD)与帕金森病(PD)相关研究。 | |||
T8986 |
ML198
|
Glucokinase | Metabolism |
ML198 是葡萄糖脑苷脂酶激活剂(EC50:0.4 μM)。它不会抑制该酶的作用,且能促进其易位至溶酶体,可用于研究戈谢病。 | |||
T0920 |
Ambroxol
氨溴索,氨溴索碱,Ambroxolum,NA-872 |
P450; Autophagy | Autophagy; Metabolism |
Ambroxol (NA-872) 是前药溴己辛的活性代谢产物,是一种分泌溶解剂,具有强效祛痰作用,用于治疗与粘液或过多粘液相关的呼吸道疾病。它可诱导肺组织细胞自噬,有用于帕金森氏病和神经性戈谢病的研究潜力。它是一种葡糖脑苷脂酶伴侣,可增加葡糖脑苷脂酶的活性。 | |||
T6234 |
Ambroxol hydrochloride
Mucosolvan,Mucoangin,盐酸氨溴索,Ambroxol HCl |
Sodium Channel; Autophagy | Autophagy; Membrane transporter/Ion channel |
Ambroxol hydrochloride (Mucosolvan) 是前药溴己辛的活性代谢产物,是一种葡糖脑苷脂酶伴侣,可增加葡糖脑苷脂酶的活性。它可刺激粘液纤毛作用并清除呼吸道中的空气通道,具有强效祛痰作用。它可诱导肺细胞自噬,有用于帕金森氏病和神经性戈谢病的研究潜力。 | |||
T40544 |
NCGC00092410
ML008 |
Glucosidase | Metabolism |
NCGC00092410 (ML008) 是一种葡萄糖脑苷脂酶 (glucocerebrosidase, GC) 抑制剂,IC50 值为 31 nM。可用于由糖脑苷酶基因突变引起的戈谢病的研究。 | |||
T8989 |
NCGC 607
NCGC607 |
Others | Others |
NCGC 607 是一种葡萄糖脑苷酶的非抑制性分子伴侣。 | |||
T4280 |
Gcase activator 1
LTI-291,LTI 291,LTI291 |
Glucosidase | Metabolism |
Gcase activator 1 (LTI-291) 是葡糖脑苷脂酶 (Gcase) 的激活剂。 | |||
T60048 |
WAY-640509
|
Glucokinase | Metabolism |
WAY-640509是一种葡糖脑苷酶抑制剂。 | |||
T8990 |
ML266
|
Glucokinase | Metabolism |
ML266 是葡萄糖脑苷脂酶 (GCase) 分子伴侣, IC50值为 2.5 µM。ML266与 GCase 结合并将其转运至溶酶体,恢复 GCase 酶的活性。ML266 不会抑制 GCase 的活性。ML266 具有研究戈谢病的潜力。 | |||
T39518 |
PFB-FDGlu
|
Others | Others |
PFB-FDGlu 是一种溶酶体葡糖脑苷脂酶(GCase)底物,具有细胞渗透特异性,裂解后产生荧光素。PFB-FDGlu 通常与流式细胞仪结合使用,以单个细胞为基础测量活细胞中 GCase 的活性。 | |||
T37440 |
C2 Adamantanyl Galactosylceramide (d18:1/2:0)
|
Others | Others |
C2 Adamantanyl Galactosylceramide (d18:1/2:0) (AdaGalCer) is a bioactive sphingolipid. It reduces globotriaosylceramide 3 synthesis from exogenous lactosylceramide in microsomes. AdaGalCer stimulates recombinant glucocerebrosidase activity in a pH-dependent manner. It activates glucocerebrosidase to decrease glucosylceramide accumulation in fibroblasts and lymphoblasts isolated from patients with Gaucher and Fabry disease, respectively. | |||
T80994 |
Therapeutic agent-1
|
Others | Others |
Therapeutic agent-1 是一种杂芳基化合物,用于戈谢病的葡萄糖脑苷脂酶活性酶替代疗法。 | |||
T38213 |
1-β-D-Glucosylsphingadienine (d18:2 (4E,8E))
1-β-D-Glucosylsphingadienine (d18:2 (4E,8E)) |
Others | Others |
1-β-D-Glucosylsphingadienine is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucosylcerebrosides . They are formed when sphingosines undergo glucosidation by UDP-glucose. Glucosylsphingosines completely reduce neurite outgrowth and induce death of LA-N-2 cells at concentrations of 10 and 50 μM, respectively. They also decrease the activity of glucocerebrosidase in LA-N-2 cells in a dose-dependent manner. Glucosylsphingosine levels are elevated in patients with Gaucher'... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T78493 |
Glucosylsphingosine
Lyso-Gb1,Glucopsychosine |
Others | Others |
Glucosylsphingosine(lyso-Gb1)作为糖基神经酰胺的脱酰基产物,同样能被糖脑苷酶所降解。该化合物是监测戈谢病的一个极具潜力、可靠且特异的生物标志物。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-05099 |
GBA/glucocerebrosidase Protein, Human, Recombinant (His)
glucosidase, β, acid,GLUC,GCB,GBA1,glucosidase, beta, acid |
Human | HEK293 Cells |
Mutations in the GBA gene, encoding the lysosomal hydrolase glucocerebrosidase (GCase), are the most common known genetic risk factor for Parkinson's disease (PD) and dementia with Lewy bodies (DLB). ASAH1 (acid ceramidase 1) and GBA2 (glucocerebrosidase 2) enzymes that mediate glucosylsphingosine production and metabolism are attractive therapeutic targets for treating mutant GBA-associated PD. | |||
TMPH-02772 |
GBA Protein, Mouse, Recombinant (His)
Cholesteryl-beta-glucosidase,Lysosomal galactosylceramidase,... |
Mouse | P. pastoris (Yeast) |
GBA Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 57.5 kDa and the accession number is P17439. | |||
TMPH-02771 |
GBA Protein, Mouse, Recombinant (His & SUMO)
Lysosomal galactosylceramidase,Cholesteryl-beta-glucosidase,... |
Mouse | E. coli |
GBA Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPH-01623 |
GBA Protein, Human, Recombinant (His & Myc & SUMO)
Lysosomal acid glucosylceramidase,GBA1,Lysosomal galactosylc... |
Human | E. coli |
Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction tha... | |||
TMPH-01624 |
GBA Protein, Human, Recombinant
Lysosomal glycosylceramidase,Acid beta-glucosidase,Alglucera... |
Human | E. coli |
Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction tha... | |||
TMPH-03342 |
GBA2 Protein, Rat, Recombinant (His)
Bile acid glucosyl transferase GBA2,Glucosylceramidase 2,Non... |
Rat | E. coli |
GBA2 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 42.6 kDa and the accession number is Q5M868. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T37928 |
13C6 Glucosylsphingosine (d18:1)
|
||
13C6 Glucosylsphingosine (d18:1) is an isotopically enriched form of 1-β-D-glucosylsphingosine (d18:1) that is intended for use as an internal standard for the quantification of 1-β-D-glucosylsphingosine by GC- or LC-MS. 1-β-D-Glucosylsphingosine is a lysolipid derivative of glucosylcerebroside that decreases activity of glucocerebrosidase in LA-N-2 cells in a dose-dependent manner. |