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Targets Recommended: Others

80

抑制剂 & 化合物

15

天然产物

2

化合物库

38

重组蛋白

5

同位素标记化合物

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Cat. No. Product Name
L9420 外泌体相关化合物库

76 compounds
76 种外泌体相关的化合物,可以用于高通量和高内涵筛选;
L5900 血脑屏障通透化合物库

509 compounds
509 个 CNS-Penetrant 生物活性小分子化合物的特有集合,用于高通量、高内涵筛选;

化合物库

外泌体相关化合物库
Cat.No: L9420
Compounds: 76
血脑屏障通透化合物库
Cat.No: L5900
Compounds: 509
Cat. No. Product Name Target Signaling Pathways
T20701 MCPA

NSC-2351,Krezone,NSC2351,NSC 2351,U 46 M-Fluid,Raphone

Others Others
MCPA(Krezone) 是一种高效的苯氧基除草剂。使用 MCPA 会对附近的水资源和土壤资源产生影响。
T2451 GlyH-101

GlyH 101

CFTR; Autophagy Autophagy; Membrane transporter/Ion channel
GlyH-101 是一种可渗透入细胞的 CFTR 阻断剂,Ki 为1.4 uM。
T0142 Brinzolamide

布林佐胺,AL-4862

Carbonic Anhydrase Metabolism
Brinzolamide (AL-4862) 是一种碳酸酐酶(carbonic anhydrase)II 抑制剂(IC50:3.19 nM)。
T8593 RU 24969 free base

5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

5-HT Receptor GPCR/G Protein; Neuroscience
RU 24969 (5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole) 是 5-HT1A 和 5-HT1B 受体的选择性激动剂,Ki 值分别为 0.38 和 2.5 nM。它可减少液体消耗并增加向前运动。
T20971 Mefluidide

VEL3973,VEL-3973,VEL 3973,MBR 12325

Others Others
Mefluidide is a biochemical.
T33930 Perfluidone

SB1528,SB 1528,Destun,SB-1528,WL 43423

Others Others
Perfluidone is a a fluorinated arylalkylsulphonamide plant growth regulator and herbicide.
T19507 Perfluamine

FTPA,Tris(perfluoropropyl)amine,Perfluorotripropylamine

Others Others
Perfluamine (FTPA) 是一种疏水性载液,可用作血液替代品。
TP1745L Ceratotoxin A acetate

Ceratotoxin A acetate(150671-04-8 Free base)

Antibacterial Microbiology/Virology
Ceratotoxin A acetate 是从副腺分泌液中分离出来的,具有抗菌作用。
T12478L Pinacidil

吡那地尔,S 1230,P 1134,S-1230,P-1134,P1134

Potassium Channel Membrane transporter/Ion channel
Pinacidil (P 1134) 是钾通道的有效激活剂。Pinacidil 通过打开 K+-通道使血管平滑肌超极化,显示出抗高血压活性。它显著改善再灌注功能和心脏顺应性。它具有直接的心脏保护作用。
T68118 Nufenoxole

Others Others
Nufenoxole 是一种具有口服活性和止泻作用的化合物,可抑制人空肠中的液体分泌。
T6581 Methyclothiazide

Duretic,Enduron,甲氯噻嗪,Aquatensen

Others; Carbonic Anhydrase Metabolism; Others
Methyclothiazide (Aquatensen) 是一种具有口服活性的利尿剂,也是一种降压剂。它能够拮抗体外的电压依赖性钙通道的 (VDCC) 活性,也可以抑制内源性血管收缩刺激导致的血管反应。
T7295 Miridesap

Ro63-8695,CPHPC,GSK2315698

Others Others
Miridesap (GSK2315698) 是一种血清淀粉样蛋白 P 组分 (SAP) 的配体,能够利用肝脏清除导致循环 SAP 的快速消耗。 它也可以明显减少脑脊液和内脏淀粉样蛋白沉积物中的 SAP。
T63540 Astrophloxine

Beta Amyloid Neuroscience
Astrophloxine 是能够靶向反平行二聚体的荧光成像探针。Astrophloxine 可用于检测阿尔茨海默症 (AD) 小鼠脑组织和脑脊液样本中聚集的Aβ。
T4103 (L)-Sodium lactate

L-乳酸钠,Sodium L-Lactate

Others Others
(L)-Sodium lactate (Sodium L-Lactate) 是由乳酸脱氢酶从丙酮酸中产生的。它在无氧糖酵解过程中或增殖活跃的细胞中产生。 它在人和动物的血液和肌肉液中少量存在。剧烈运动后,肌肉和血液中的乳酸浓度会增加。 它也存在于肝脏、肾脏、胸腺、人羊水以及其他器官和体液中。
TQ0291 Firategrast

SB 683699

Integrin Cytoskeletal Signaling
Firategrast (SB 683699) 是一种具有口服活性和特异性的α4β1/α4β7整合素拮抗剂。Firategrast 减少淋巴细胞进入中枢神经系统 (CNS) 的运输,降低多发性硬化症 (MS) 的活性。Firategrast 用于复发缓解性多发性硬化症。Firategrast 治疗与中位脑脊液与 CD4,CD8和CD19淋巴细胞计数的适度降低有关。
T31751 Fce 21258

Ddh-carbo pgl2

Others Others
Fce 21258 is used to stimulate the adenylate cyclase of synovial fluid macrophages.
T32098 Homocarnosine

NSC-92522,NSC92522,高肌肽,L-Homocarnosine,NSC 92522

Others Others
Homocarnosine is an endogenous dipeptide in cerebral regions and cerebrospinal fluid.
T71738 DRAinh-A250

Others Others
DRAinh-A250 is a SLC26A3 inhibitor which blocks colonic fluid absorption and reduces constipation.
T35849 17(S)-HETE

Others Others
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites.17-HETE is a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney.17(S)-HETE inhibits proximal tubule ATPase activity by as much as 70% at a concentration of 2 μM.
TP1745 Ceratotoxin A

Ceratotoxin A is a 29-residue peptide extracted from the accessory gland secretion fluid, known for its potent antibacterial properties.
T22551 ACSF

Others Others
ACSF is often used as a replacement of CSF for perfusion of brain slices to preserve interneurons. ACSF is invented to reduce the incidence of cerebral edema and further suppress brain cell disorders. And ACSF is often used as an irrigation fluid or perfu
T27243 Efipladib

PLA-902,PLA 902,PLA902

Others Others
Efipladib is a phospholipase inhibitor. Efipladib decreases nociceptive responses without affecting PGE2 levels in the cerebral spinal fluid.
T37863 9(S),10(S),13(S)-TriHOME

Others Others
9(S),10(S),13(S)-TriHOME is an oxylipin derived from linoleic acid. It has been detected in beer and in bronchoalveolar lavage fluid (BALF) from female smokers.
T69287 NAA-004

Others Others
NAA-004, also known as APAZA, has been shown to significantly inhibit toxin A-induced myeloperoxidase activity, luminal fluid accumulation, and structural damage to the colon in instances of toxin A-induced colitis.
T85254 1,2-Dinonadecanoyl-sn-glycero-3-PC

1,2-DNPC,PC (19:0/19:0),1,2-Dinonadecanoyl-sn-glycero-3-phosphocholine

Others Others
1,2-Dinonadecanoyl-sn-glycero-3-PC (DNPC), a saturated phospholipid, serves as a standard in quantifying phosphatidylcholines in human synovial fluid and has been utilized in researching lipid bilayer phase transition dynamics.
T73795 Normetanephrine

Others Others
Normetanephrine 是存在于脑脊液中的内源代谢物,可用于研究高血压。
T37708 17(R)-HETE

Others Others
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 17-HETE is a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney. 17(R)-HETE is an inactive isomer of 17-HETE, whereas the (S) enantiomer can inhibit proximal tubule ATPase activity at a concentration of 2 μM.
T34107 Polythiazide

P2525,NSC-108161,NSC 108161,P-2525,NSC108161

Others Others
Polythiazide (NSC-108161, P-2525) is used to treat fluid retention (edema) caused by a variety of causes, including congestive heart failure, severe liver disease (cirrhosis), kidney disease, or steroid or hormonal medication.
T68344 AGG-523

Others Others
AGG-523 is an aggrecanase specific inhibitor that has been shown to attenuate increases in synovial fluid ARG-aggrecan levels following surgically-induced joint instability in the rat MT model. Pharmacologic inhibition of aggrecanase activity in humans using AGG-523 may be an effective treatment for slowing cartilage degradation following joint injury.
T37373 4-hydroxy-3-Methoxyphenylglycol (piperazine salt)

Others Others
4-hydroxy-3-Methoxyphenylglycol (piperazine salt) is a metabolite of norepinephrine derived in part by deamination of normetanephrine or by O-methylation of dihydroxyphenylglycol after cellular uptake of either intermediate. It is released into the blood and cerebrospinal fluid and has been used as a biochemical index of recent sympathetic nervous system activity.
T39244 Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled

Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled, is one of three mammalian natriuretic peptides (NPs) that exerts endocrine effects on fluid homeostasis and blood pressure. Atrial Natriuretic Peptide holds promise for cardiovascular diseases research.
T84461 Lignoceroyl Ethanolamide

Others Others
Lignoceroyl ethanolamide, a fatty N-acyl ethanolamine within the endocannabinoid family, is derived from lignoceric acid, which is found in relatively high concentrations in rat cerebrospinal fluid. However, the specific function and significance of this metabolite remain unclear.
TP1866 β-Amyloid (1-11)

β-amyloid 1-11

Anionic interaction of Beta-amyloid (1-11) with Factor XII is suspected to cause massive activation of the C4 (complement 4) system in the cerebrospinal fluid of Alzheimer’s disease patients.
T35847 16(R)-HETE

Others Others
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 16-HETE is a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation that demonstrates stereospecific biological activity. Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 16-HETE is a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation that...
T70807 Lanabecestat HCl

Others Others
Lanabecestat, also known as AZD3293 and LY3314814, is a potent, highly permeable, orally active, blood-brain barrier (BBB) penetrating, BACE1 inhibitor with unique slow off-rate kinetics. AZD3293 displayed significant dose- and time-dependent reductions in plasma, cerebrospinal fluid, and brain concentrations of Aβ40, Aβ42, and sAβPPβ.
T39823 Apelin-12

Apelin-12 is a highly potent C-terminal fragment of a polypeptide that exhibits a strong affinity towards the orphan receptor APJ. It plays a role in maintaining body fluid balance and regulating feeding control in the central nervous system. Additionally, Apelin-12 functions as an inhibitor of HIV-1 entry through the APJ receptor and demonstrates neuroprotective properties.
T35848 16(S)-HETE

Others Others
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 16-HETE is a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation that demonstrates stereospecific biological activity. 16(S)-HETE inhibits proximal tubule ATPase activity by as much as 60% at a concentration of 2 μM.
T84398 8,12-iso-iPF2α-VI

12-iso-5,6E,14Z-PGF2α,12-iso-5,6E,14Z-Prostaglandin F2α,8,12-iso-Isoprostane-F2α-VI

Others Others
8,12-iso-iPF2α-VI, an isoprostane, arises from non-enzymatic, free radical-induced peroxidation of membrane lipids. It is the predominant isoprostane formed during lipid peroxidation and serves as a biomarker for oxidative stress. Detectable in hepatic tissue post CCl4-induced oxidative damage, 8,12-iso-iPF2α-VI levels are also elevated in the urine, blood, and cerebrospinal fluid of Alzheimer’s disease patients.
T81539 PAT1inh-B01

Others Others
PAT1inh-B01为选择性SLC26A6抑制剂,抑制PAT1(Cl-/HCO3-交换器)介导的阴离子交换(IC50: 350 nM),并阻断小肠液体吸收,适用于小肠分泌不足相关疾病研究。
TP2094 Apelin-36(rat, mouse)

Apelin-36 (rat, mouse)

Endogenous APJ receptor agonist that is secreted by adipocytes. Binds with high affinity to APJ receptors (IC50 = 5.4 nM) and potently inhibits cAMP production in vitro (EC50 = 0.52 nM). Involved in regulation of cardiovascular function, fluid homeostasis
T22575 Angiotensin Fragment 1-7 (acetate)

Others Others
Angiotensin Fragment 1-7 is a type 1 angiotensin II receptor agonist. In the renin-angiotensin system, angiotensin I is cleaved by the angiotensin-converting enzyme to form angiotensin II, which has effects on fluid and electrolyte, as well as homeostasis
TP2093 Apelin-36(human)

Apelin-36 (human)

Endogenous APJ receptor agonist (EC50 = 20 nM) that is secreted by adipocytes. Binds with high affinity to human APJ receptors expressed in HEK 293 cells (pIC50= 8.61). Involved in regulation of cardiovascular function, fluid homeostasis and feeding. Bloc
T80438 Atrial natriuretic peptide (3-28) (human)

ANP (3-28) (human)

Endothelin Receptor GPCR/G Protein
Atrial natriuretic peptide (3-28) (human) 是由心房心肌细胞合成并分泌的肽类激素,主要在调节血压、体液平衡及电解质稳态方面发挥作用。
TP1048 Secretin, porcine

Porcine secretin acetate

Secretin, porcine (Porcine secretin acetate) is a 27-amino acid peptide, acting on pancreatic acinar cells and ductal epithelial cells stimulating the production of bicarbonate rich fluid. Secretin porcine stimulates pancreatic and gastric secretions to a
T75973 Secretin, porcine TFA

Porcine secretin TFA (Porcine secretin TFA) 是一种含有27个氨基酸的多肽,能够影响胰腺腺泡细胞和导管上皮细胞,促进碳酸氢盐丰富的流体生成。
T77109 Omfiloctocog alfa

Omfiloctocog alfa (SCT-800) 是一种重组的 factor VIII(FVIII)。FVIII 是一种必需的凝血蛋白,是液相凝血系统的关键组成部分。Omfiloctocog alfa 可用于血友病 A 的研究。
T73783 D-Ribofuranose

Others Others
D-Ribofuranose (D-Ribose) 是一种在脑脊液中发现的内源性代谢物,用于磷酸 5 核糖异构酶缺乏症和中链酰基 CoA 脱氢酶缺乏症的研究。
T76178 Aspartate aminotransferase

Aspartate aminotransferase (AST) 是一种转氨酶,常用于生化研究。Aspartate aminotransferase 催化天冬氨酸和 α-酮戊二酸转化为草酰乙酸和谷氨酸。Aspartate aminotransferase 可存在于在脑脊液、渗出液和渗出物。
T70800 Elenbecestat free base

Others Others
Elenbecestat,also known as E2609 is a BACE1 inhibitor. By inhibiting BACE, a key enzyme in the production of Aβ peptides, E2609 decreases the formation of these peptides which can aggregate into toxic oligomers and protofibrils and eventually form amyloid plaques in the brain. Elenbecestat has been shown to reduce Aβ levels in cerebrospinal fluid, was investigated in two global phase 3 studies in early AD.
T69664 Umibecestat HCl

Others Others
Umibecestat, also known as CNP-520, is a beta-secretase inhibitor and is a drug candidate for prevention trials in Alzheimer's disease. CNP520 has a selectivity, pharmacodynamics, and distribution profile suitable for AD prevention studies. CNP520 reduced brain and cerebrospinal fluid (CSF) Aβ in rats and dogs, and Aβ plaque deposition in APP-transgenic mice. CNP520 reduces Aβ load and neuroinflammation in APP‐transgenic mice

化合物

MCPA
Cat.No: T20701
Synonym: NSC-2351,Krezone,NSC2351,NSC 2351,U 46 M-Fluid,Raphone
Target: Others
GlyH-101
Cat.No: T2451
Synonym: GlyH 101
Target: CFTR, Autophagy
Brinzolamide
Cat.No: T0142
Synonym: 布林佐胺,AL-4862
Target: Carbonic Anhydrase
RU 24969 free base
Cat.No: T8593
Synonym: 5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole
Target: 5-HT Receptor
Mefluidide
Cat.No: T20971
Synonym: VEL3973,VEL-3973,VEL 3973,MBR 12325
Target: Others
Perfluidone
Cat.No: T33930
Synonym: SB1528,SB 1528,Destun,SB-1528,WL 43423
Target: Others
Perfluamine
Cat.No: T19507
Synonym: FTPA,Tris(perfluoropropyl)amine,Perfluorotripropylamine
Target: Others
Ceratotoxin A acetate
Cat.No: TP1745L
Synonym: Ceratotoxin A acetate(150671-04-8 Free base)
Target: Antibacterial
Pinacidil
Cat.No: T12478L
Synonym: 吡那地尔,S 1230,P 1134,S-1230,P-1134,P1134
Target: Potassium Channel
Nufenoxole
Cat.No: T68118
Synonym:
Target: Others
Methyclothiazide
Cat.No: T6581
Synonym: Duretic,Enduron,甲氯噻嗪,Aquatensen
Target: Others, Carbonic Anhydrase
Miridesap
Cat.No: T7295
Synonym: Ro63-8695,CPHPC,GSK2315698
Target: Others
Astrophloxine
Cat.No: T63540
Synonym:
Target: Beta Amyloid
(L)-Sodium lactate
Cat.No: T4103
Synonym: L-乳酸钠,Sodium L-Lactate
Target: Others
Firategrast
Cat.No: TQ0291
Synonym: SB 683699
Target: Integrin
Fce 21258
Cat.No: T31751
Synonym: Ddh-carbo pgl2
Target: Others
Homocarnosine
Cat.No: T32098
Synonym: NSC-92522,NSC92522,高肌肽,L-Homocarnosine,NSC 92522
Target: Others
DRAinh-A250
Cat.No: T71738
Synonym:
Target: Others
17(S)-HETE
Cat.No: T35849
Synonym:
Target: Others
Ceratotoxin A
Cat.No: TP1745
Synonym:
Target:
ACSF
Cat.No: T22551
Synonym:
Target: Others
Efipladib
Cat.No: T27243
Synonym: PLA-902,PLA 902,PLA902
Target: Others
9(S),10(S),13(S)-TriHOME
Cat.No: T37863
Synonym:
Target: Others
NAA-004
Cat.No: T69287
Synonym:
Target: Others
1,2-Dinonadecanoyl-sn-glycero-3-PC
Cat.No: T85254
Synonym: 1,2-DNPC,PC (19:0/19:0),1,2-Dinonadecanoyl-sn-glycero-3-phosphocholine
Target: Others
Normetanephrine
Cat.No: T73795
Synonym:
Target: Others
17(R)-HETE
Cat.No: T37708
Synonym:
Target: Others
Polythiazide
Cat.No: T34107
Synonym: P2525,NSC-108161,NSC 108161,P-2525,NSC108161
Target: Others
AGG-523
Cat.No: T68344
Synonym:
Target: Others
4-hydroxy-3-Methoxyphenylglycol (piperazine salt)
Cat.No: T37373
Synonym:
Target: Others
Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled
Cat.No: T39244
Synonym:
Target:
Lignoceroyl Ethanolamide
Cat.No: T84461
Synonym:
Target: Others
β-Amyloid (1-11)
Cat.No: TP1866
Synonym: β-amyloid 1-11
Target:
16(R)-HETE
Cat.No: T35847
Synonym:
Target: Others
Lanabecestat HCl
Cat.No: T70807
Synonym:
Target: Others
Apelin-12
Cat.No: T39823
Synonym:
Target:
16(S)-HETE
Cat.No: T35848
Synonym:
Target: Others
8,12-iso-iPF2α-VI
Cat.No: T84398
Synonym: 12-iso-5,6E,14Z-PGF2α,12-iso-5,6E,14Z-Prostaglandin F2α,8,12-iso-Isoprostane-F2α-VI
Target: Others
PAT1inh-B01
Cat.No: T81539
Synonym:
Target: Others
Apelin-36(rat, mouse)
Cat.No: TP2094
Synonym: Apelin-36 (rat, mouse)
Target:
Angiotensin Fragment 1-7 (acetate)
Cat.No: T22575
Synonym:
Target: Others
Apelin-36(human)
Cat.No: TP2093
Synonym: Apelin-36 (human)
Target:
Atrial natriuretic peptide (3-28) (human)
Cat.No: T80438
Synonym: ANP (3-28) (human)
Target: Endothelin Receptor
Secretin, porcine
Cat.No: TP1048
Synonym: Porcine secretin acetate
Target:
Secretin, porcine TFA
Cat.No: T75973
Synonym:
Target:
Omfiloctocog alfa
Cat.No: T77109
Synonym:
Target:
D-Ribofuranose
Cat.No: T73783
Synonym:
Target: Others
Aspartate aminotransferase
Cat.No: T76178
Synonym:
Target:
Elenbecestat free base
Cat.No: T70800
Synonym:
Target: Others
Umibecestat HCl
Cat.No: T69664
Synonym:
Target: Others
Cat. No. Product Name Target Signaling Pathways
T4884 alpha-D-glucose

α-D-Glucose,α-葡萄糖,alpha-Glucose,α-Dextrose

Others; Endogenous Metabolite Metabolism; Others
alpha-D-glucose (α-Dextrose) 是内源性代谢产物的一种。
T5224 2-Hydroxyhexanoic acid

DL-2-羟己酸,2-Hydroxycaproic acid

Others; Endogenous Metabolite Metabolism; Others
2-Hydroxyhexanoic acid (2-Hydroxycaproic acid) 是内源性代谢产物的一种。
T3762 Hyaluronic acid

透明质酸,Hyaluronate,玻尿酸,hyaluronan

Others; Endogenous Metabolite Metabolism; Others
Hyaluronic acid (hyaluronan) 由玉米发酵得到,是由二糖的重复单元组成的生物聚合物,应用领域广泛。
TN7246 3-Sulfopropanoic acid

3-SPA

Drug Metabolite Metabolism
3-Sulfopropanoic acid 是曲吡罗酯及其前药ALZ-801的主要代谢产物,是存在于AD患者的脑脊液(CSF)中的内源性分子,可抑制 Aβ42 寡聚体的形成。
T4710 3-Methoxytyramine hydrochloride

3-O-methyl Dopamine hydrochloride,3-O-methyl Dopamine hydrochloride),3-O-甲基多巴胺盐酸盐

Others; Endogenous Metabolite; Drug Metabolite Metabolism; Others
3-Methoxytyramine hydrochloride (3-O-methyl Dopamine hydrochloride) 是多巴胺的无活性代谢物,能够活化痕量胺相关受体1 。
T13516 5-Methyltetrahydrofolic acid

甲基叶酸盐,5-Methyl THF

Endogenous Metabolite Metabolism
5-Methyltetrahydrofolic acid (5-Methyl THF) 是四氢叶酸的甲基化衍生物,具有生物活性。5-Methyltetrahydrofolic acid 是主要的天然膳食叶酸,是血浆和脑脊液中叶酸的主要形式。
T0887 D-Glucose

Dextrose,D-无水葡萄糖,Glucopyranose,Grape sugar,葡萄糖,D(+)-Glucose

Endogenous Metabolite Metabolism
D-Glucose (Glucopyranose) 是一种单糖。D-Glucose 是甜味剂,是一般代谢的关键组成部分,并作为与细胞代谢状态以及生物和非生物应激反应有关的关键信号分子。
T5S0106 Peimisine

贝母辛,Ebeiensine

RAAS; AChR Endocrinology/Hormones; Neuroscience
Peimisine (Ebeiensine) 非竞争性拮抗气管平滑肌 M 受体,抑制 Ach 引起的平滑肌收缩。它兴奋 β 受体和拮抗内钙释放,促进一氧化氮释放,可舒张气管平滑肌,有平喘作用。
T8053 N-Acetyl-L-arginine

N-Α-乙酰-L-精氨酸,Ac-Arg-OH

Endogenous Metabolite Metabolism
N-Acetyl-L-arginine (Ac-Arg-OH) 是一种胍基诺化合物,被发现存在于血液渗析性肾不足儿童患者血清中的。
T37499 Estriol 3-glucuronide

Others Others
Estriol-3-glucuronide, a natural compound found in urine, is also present in amniotic fluid during normal pregnancy [1][2].
TN3114 5-Hydroxy-1-(4-hydroxyphenyl)-7-phenyl-3-heptanone (AO 2210)

Others Others
(±)-5-hydroxyl-1-(4'-hydroxyphenyl)-7-phenyl-3-heptanone have digestibility inhibition in vitro in cow rumen fluid.
TN6685 Homovanillic Acid Sulfate

Homovanillic acid sulfate is used as a reagent to detect oxidative enzymes, and is associated with dopamine levels in the brain.In psychiatry and neuroscience, brain and cerebrospinal fluid levels of homovanillic acid are measured as a marker of metabolic
T21893 Luffariellolide

Others Others
Luffariellolide 是人滑膜蛋白磷脂酶A2 (HSF-PLA2) 抑制剂 (IC50=5 μM)。Luffariellolide (ED50=50 μg/耳)可有效抑制佛波酯 (PMA) 引起的耳水肿。
TN5147 Tilifodiolide

IL Receptor; TNF; GABA Receptor Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience
Tilifodiolide exerts in vitro and in vivo anti-inflammatory activity and in vivo antinociceptive effects. Tilifodiolide exerted antidiarrheal activity by decreasing the intestinal fluid accumulation and vasorelaxant effects mediated by nitric oxide and cyclic guanosine monophosphate, it also showed anxiolytic and antidepressant effects by the partial involvement of gamma-Aminobutyric acid (GABA) receptors and the possible participation of α2-adrenoreceptors, respectively.
TN4505 Masticadienolic acid

Others Others
Masticadienolic acid is a specific competitive inhibitor of secreted phospholipase A2, it not only protects the active site histidine from alkylation but also inhibits the action of secreted from pancreas, synovial fluid, and bee venom. Masticadienolic ac

天然产物

alpha-D-glucose
Cat.No: T4884
Synonym: α-D-Glucose,α-葡萄糖,alpha-Glucose,α-Dextrose
Target: Others, Endogenous Metabolite
2-Hydroxyhexanoic acid
Cat.No: T5224
Synonym: DL-2-羟己酸,2-Hydroxycaproic acid
Target: Others, Endogenous Metabolite
Hyaluronic acid
Cat.No: T3762
Synonym: 透明质酸,Hyaluronate,玻尿酸,hyaluronan
Target: Others, Endogenous Metabolite
3-Sulfopropanoic acid
Cat.No: TN7246
Synonym: 3-SPA
Target: Drug Metabolite
3-Methoxytyramine hydrochloride
Cat.No: T4710
Synonym: 3-O-methyl Dopamine hydrochloride,3-O-methyl Dopamine hydrochloride),3-O-甲基多巴胺盐酸盐
Target: Others, Endogenous Metabolite, Drug Metabolite
5-Methyltetrahydrofolic acid
Cat.No: T13516
Synonym: 甲基叶酸盐,5-Methyl THF
Target: Endogenous Metabolite
D-Glucose
Cat.No: T0887
Synonym: Dextrose,D-无水葡萄糖,Glucopyranose,Grape sugar,葡萄糖,D(+)-Glucose
Target: Endogenous Metabolite
Peimisine
Cat.No: T5S0106
Synonym: 贝母辛,Ebeiensine
Target: RAAS, AChR
N-Acetyl-L-arginine
Cat.No: T8053
Synonym: N-Α-乙酰-L-精氨酸,Ac-Arg-OH
Target: Endogenous Metabolite
Estriol 3-glucuronide
Cat.No: T37499
Synonym:
Target: Others
5-Hydroxy-1-(4-hydroxyphenyl)-7-phenyl-3-heptanone (AO 2210)
Cat.No: TN3114
Synonym:
Target: Others
Homovanillic Acid Sulfate
Cat.No: TN6685
Synonym:
Target:
Luffariellolide
Cat.No: T21893
Synonym:
Target: Others
Tilifodiolide
Cat.No: TN5147
Synonym:
Target: IL Receptor, TNF, GABA Receptor
Masticadienolic acid
Cat.No: TN4505
Synonym:
Target: Others
Cat. No. Product Name Species Expression System
TMPY-04912 PLA2G2A Protein, Mouse, Recombinant (His)

Pla2,sPLA2,sPla2-IIA,Mom1,EF,phospholipase A2, group IIA (pl...

Mouse P. pastoris (Yeast)
PLA2G2A Protein, Mouse, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 15.3 kDa and the accession number is P31482.
TMPY-01705 PLA2G2A Protein, Human, Recombinant (His)

PLAS1,phospholipase A2, group IIA (platelets, synovial f...

Human HEK293 Cells
PLA2G2A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.4 kDa and the accession number is A0A024RA96.
TMPH-01916 PIP Protein, Human, Recombinant (His)

gp17,Secretory actin-binding protein,Gross cystic disease

Human E. coli
PIP Protein, Human, Recombinant (His) is expressed in E. coli.
TMPK-00019 B2M/beta 2-Microglobulin Protein, Human, Recombinant (hFc)

Beta-2-microglobulin,B2M/β 2-Microglobulin,β-2-microglobulin...

Human HEK293 Cells
To assess whether beta-2 microglobulin (B2M) has effects on articular chondrocytes that would implicate B2M involvement in osteoarthritis (OA) pathogenesis.The average B2M level in OA synovial fluid is significantly higher than that found in normal synovial fluid. B2M is highly expressed in OA cartilage and synovial fluid compared to normal, and suggest that B2M may have effects on chondrocyte function that could contribute to OA pathogenesis.
TMPJ-00759 VDB Protein, Human, Recombinant (His)

Group-Specific Component,DBP,VDB,GC,Gc-Globulin,Vitamin D-Bi...

Human HEK293 Cells
Vitamin D-Binding Protein (DBP) is a member of the ALB/AFP/VDB family. DBP is a secreted protein and contains three albumin domains. The primary structure contains 28 cysteine residues forming multiple disulfide bonds. DBP acts as a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. DBP binds to vitamin D and its plasma metabolites and transports them to target tissues. DBP associates with membrane-bound immunoglobulin on...
TMPK-01388 GUCY2C Protein, Canine, Recombinant (aa 21-430, His)

GC-C,GUCY2C,STAR,EC 4.6.1,STA receptor,GCC,MUCIL,Guanylyl cy...

Canine HEK293 Cells
Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier function. GUCY2C may represent a new target for anti-obesity pharmacotherapy. GUCY2C Protein, Canine, Recombinant (aa 21-430, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 47.6 kDa and the accession number is F1PAG3.
TMPK-00991 GUCY2C Protein, Mouse, Recombinant (His & Avi), Biotinylated

EC 4.6.1,Guanylyl cyclase C,MUCIL,GUC2CEC 4.6.1.2,GUC2C,STA ...

Mouse HEK293 Cells
Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier function. GUCY2C may represent a new target for anti-obesity pharmacotherapy. GUCY2C Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 50.01 kDa and the accession number is Q3UWA6-1.
TMPK-01279 GUCY2C Protein, Cynomolgus, Recombinant (aa 24-430, His)

GUC2CEC 4.6.1.2,GCC,Guanylyl cyclase C,STA receptor,MUCIL,GU...

Cynomolgus HEK293 Cells
Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier function. GUCY2C may represent a new target for anti-obesity pharmacotherapy. GUCY2C Protein, Cynomolgus, Recombinant (aa 24-430, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 47.2 kDa and the accession number is XP_005570270.1.
TMPK-00856 GUCY2C Protein, Human, Recombinant (His & Avi)

GCC,STAR,STA receptor,Guanylyl cyclase C,EC 4.6.1,GUC2C,MUCI...

Human HEK293 Cells
Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier function. GUCY2C may represent a new target for anti-obesity pharmacotherapy. GUCY2C Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 48.8 kDa and the accession number is P25092-1.
TMPJ-00490 Serpin A5 Protein, Human, Recombinant (His)

Plasminogen Activator Inhibitor 3,Acrosomal Serine Protease ...

Human HEK293 Cells
Serpin A5 is a member of the human Serpin superfamily consists of at least 35 members. It is synthesized in the liver and has been detected in saliva, cerebral spinal fluid, amniotic fluid, tears and semen. As a potent inhibitor of the protein C anticoagulant pathway at the levels of both zymogen activation and enzyme inhibition, Serpin A5 additionally inhibits a variety of serine protease including thrombin, factor Xa, several kallekreins and acrosin. It plays a critical role in the processes o...
TMPK-00990 GUCY2C Protein, Mouse, Recombinant (His & Avi)

GC-C,STAR,DIAR6,GCC,GUC2CEC 4.6.1.2,STA receptor,MUCIL,GUCY2...

Mouse HEK293 Cells
Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier function. GUCY2C may represent a new target for anti-obesity pharmacotherapy. GUCY2C Protein, Mouse, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 50.01 kDa and the accession number is Q3UWA6-1.
TMPK-01201 BPIFA1/LUNX Protein, Human, Recombinant

Lung-specific protein X,BPI fold-containing family A member ...

Human E. coli
Bactericidal/permeability-increasing fold containing family A, member 1 (BPIFA1) is a secretory protein found in human upper aerodigestive tract mucosa. This innate material is secreted in mucosal fluid or found in submucosal tissue in the human soft palate, lung, uvula, and nasal cavity. BPIFA1 is a critical component of the innate immune response that prevents upper airway diseases.
TMPH-01424 GUCA2B Protein, Human, Recombinant (His)

Guanylate cyclase activator 2B,GUCA2B

Human HEK293 Cells
Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport. GUCA2B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 13.5 kDa and the accession number is Q16661.
TMPH-01973 Proteoglycan 4 Protein, Human, Recombinant (His)

PRG4,Megakaryocyte-stimulating factor,Superficial zone prote...

Human P. pastoris (Yeast)
Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface.; Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages. Proteoglycan 4 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 1...
TMPJ-00740 PTH Protein, Human, Recombinant

PTH,Parathyrin,Parathyroid Hormone,Parathormone

Human E. coli
Parathyroid hormone is the most important endocrine regulator of calcium and phosphorus concentration in extracellular fluid. This hormone is secreted from cells of the parathyroid glands and finds its major target cells in bone and kidney. Another hormone, parathyroid hormone-related protein, binds to the same receptor as parathyroid hormone and has major effects on development. Like most other protein hormones, parathyroid hormone is synthesized as a preprohormone. After intracellular processi...
TMPJ-00227 Follistatin 288 Protein, Human, Recombinant (His)

FSActivin-binding protein,Follistatin,follistatin isoform FS...

Human HEK293 Cells
Follistatin 288 is a secreted glycoprotein that was first identified as a follicle-stimulating hormone inhibiting substance in ovarian follicular fluid . Human follistatin 288 cDNA encodes a 317 amino acid (aa) protein with a 29 aa signal sequence, and a 288 aa mature region. Follistatin shows the highest affinity for activins due to its extended configuration. Genetic deletion of follistatin in mice, or expression of only the Follistatin form, is perinatally lethal due to defects of lung, skin ...
TMPJ-00701 Carbonic Anhydrase 11 Protein, Human, Recombinant (His)

Carbonic Anhydrase-Related Protein 2,CARP XI,CA11,CARP-2,Car...

Human HEK293 Cells
Carbonic Anhydrase-Related Protein 11 (CA11) is a secreted protein member of the α-carbonic anhydrase family. Carbonic Anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. CA11 is expressed abundantly in the brain with moder...
TMPY-01933 CHI3L2 Protein, Human, Recombinant (His)

YKL-39,CHIL2,chitinase 3 like 2,YKL39

Human HEK293 Cells
Chondrocyte protein 39 (YKL-39), also known as Chitinase 3-like 2 (CHI3L2), is a secretory protein of articular chondrocytes belonging to the glycosyl hydrolase 18 family. Its highest expression is in chondrocytes, followed by synoviocytes, lung and heart. YKL-39/CHI3L2 is not detected in spleen, pancreas, and liver. YKL-39/CHI3L2 may also be expressed in developing brain and placenta. YKL-39/CHI3L2, a cartilage-related protein, is found to induce arthritis accompanied by pathologic changes in b...
TMPY-01679 LCN1 Protein, Human, Recombinant (His)

TLC,MGC71975,TP,VEGP,Lipocalin 1,PMFA

Human HEK293 Cells
Lipocalin-1, also known as Von Ebner gland protein, VEG protein, Tear Prealbumin, VEGP, Tear lipocalin, and LCN1 is a secreted protein that belongs to the calycin superfamily and Lipocalin family. Human Lipocalin-1 / VEGP was originally described as a major protein of human tear fluid, which was thought to be tear specific. Lipocalin-1 / VEGP is identical to lingual von Ebner's gland protein and is also produced in the prostate, nasal mucosa, and tracheal mucosa. Homologous proteins have been fo...
TMPY-01877 CA5A Protein, Human, Recombinant (His)

CA5,GS1-21A4.1,CA5AD,carbonic anhydrase VA, mitochondrial,CA...

Human E. coli
Carbonic anhydrase 5A, mitochondrial, also known as Carbonate dehydratase VA, Carbonic anhydrase VA, CA-VA and CA5A, is a member of thealpha-carbonic anhydrase family. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospi...
TMPY-02277 Carbonic Anhydrase 7 Protein, Human, Recombinant (His)

CAVII,carbonic anhydrase VII

Human E. coli
Carbonic anhydrase 7, also known as carbonate dehydratase VII, carbonic anhydrase VII, CA-VII and CA7, is a cytoplasm protein which belongs to thealpha-carbonic anhydrase family. Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, ...
TMPY-03109 PHYH Protein, Human, Recombinant

PHYH1,RD,PAHX,LN1,phytanoyl-CoA 2-hydroxylase,LNAP1

Human E. coli
PHYH belongs to the family of iron(II)-dependent oxygenases, which typically incorporate one atom of dioxygen into the substrate and one atom into the succinate carboxylate group. PHYH is expressed in liver, kidney, and T-cells, but not in spleen, brain, heart, lung and skeletal muscle. It converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA. Defects in PHYH can cause Refsum disease (RD). RD is an autosomal recessive disorder characterized clinically by a tetrad of abnormalities: retinitis pigmentos...
TMPJ-00234 AMBP Protein, Human, Recombinant (His)

α-1-Microglobulin,Uronic-Acid-Rich Protein,Inter-α-Trypsin I...

Human HEK293 Cells
Protein AMBP belongs to the calycin superfamily and Lipocalin family. AMBP can be cleaved into three chains: α-1-microglobulin, inter-α-trypsin inhibitor light chain and trypstatin. AMBP is expressed by the liver and secreted in plasma. α-1-microglobulin occurs in many physiological fluids including the plasma, urine, and cerebrospinal fluid. Inter-α-trypsin inhibitor is present in the plasma and urine. α-1-microglobulin occurs as a monomer and also in complexes with IgA and albumin, Inter-α-try...
TMPJ-00981 PTX3 Protein, Mouse, Recombinant (His)

alpha-induced protein 5,pentraxin 3, long,pentaxin-related g...

Mouse HEK293 Cells
Pentraxin-related protein PTX3, also known as Tumor necrosis factor-inducible gene 14 protein (TSG-14), belongs to the pentraxin family. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. It’s subunit is a disulfide-linked homooctamer that binds to C1q. PTX3 concentration is elevated in the joint fluid of patients with rheumatoid arthritis (RA), indicating that PTX3 may be a potential mediator...
TMPY-02070 Cystatin SN Protein, Human, Recombinant (His)

CST1,cystatin SN

Human HEK293 Cells
Cystatin-SN, also known as Cystain-SA-I, Cystatin-1, Salivary cystatin-SA-1 and CST1, is a secreted protein which belongs to thecystatin family. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. Cystatin-SN / CST1 is expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Cy...
TMPY-02081 PDE2A Protein, Human, Recombinant (aa 215-900, His)

phosphodiesterase 2A, cGMP-stimulated,cGSPDE,PED2A4,PDE2A1,C...

Human Baculovirus Insect Cells
cGMP-dependent 3',5'-cyclic phosphodiesterase, also known as cyclic GMP-stimulated phosphodiesterase and PDE2A, is a peripheral membrane protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE2 subfamily. Phosphodiesterases (PDEs) comprise a family of enzymes that regulate the levels of cyclic nucleotides, key second messengers that mediate a diverse array of functions. Phosphodiesterases (PDEs) modulate signaling by cyclic nucleotides in diverse processes such as cardiac ...
TMPJ-00741 PTH Protein, Human, Recombinant (His)

Parathyroid hormone,Parathyrin,PTH,Parathormone

Human HEK293 Cells
Parathyroid hormone (PTH) is a critical hormone in the regulation of Ca++ homeostasis. Parathyroid hormone is the most important endocrine regulator of calcium and phosphorus concentration in extracellular fluid. This hormone is secreted from cells of the parathyroid glands and finds its major target cells in bone and kidney. Another hormone, parathyroid hormone-related protein, binds to the same receptor as parathyroid hormone and has major effects on development. Like most other protein hormon...
TMPY-02839 Adrenomedullin Protein, Human, Recombinant (hFc)

AM,PAMP,adrenomedullin

Human HEK293 Cells
Adrenomedullin consists of 52 amino acids and is a member of the adrenomedullin family. It s a a hypotensive peptide and has 1 intramolecular disulfide bond. It seems that adrenomedullin has a slight homology with the calcitonin gene-related peptide. Adrenomedullin has a highly expression in pheochromocytoma and adrenal medulla. It also can be detected in lung, ventricle and kidney tissues. Adrenomedullin and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been report...
TMPY-02549 GBP1 Protein, Human, Recombinant (His)

guanylate binding protein 1,GBP1

Human HEK293 Cells
Guanylate-binding protein 1 (GBP-1) is a member of the GBP family whose members are GTPases induced in response to interferon-λ (IFN-λ), with seven highly homologous members in humans, termed HuGBP-1 to HuGBP-7. GBP-1 expression is induced by type1 and type2 interferons, including IFN-λ and also by interleukin-1β (IL-1β), IL-1α, and tumor necrosis factor-α (TNF-α). GBP-1 is key to the protective immunity against microbial and viral pathogens. GBP-1 was only secreted from endothelial cells. Secre...
TMPY-03963 CALCB Protein, Human, Recombinant (mFc)

CGRP-II,calcitonin-related polypeptide β,calcitonin-related ...

Human HEK293 Cells
CALCB, also known as CGPR and calcitonin 2, belongs to the calcitonin family. CALCB is a calcitonin (CT) peptide which may play a role in the mediation of human inflammatory diseases. It is highly expressed in the skin, blood, and cerebrospinal fluid. CGRP immunolabeling (IL) was detected in epidermal keratinocytes at levels that were especially high and widespread in the skin of humans from locations afflicted with postherpetic neuralgia (PHN) and complex region pain syndrome type 1 (CRPS), of ...
TMPY-02248 Myocilin Protein, Human, Recombinant (His)

myocilin, trabecular meshwork inducible glucocorticoid respo...

Human HEK293 Cells
Myocilin, also known as Trabecular meshwork-induced glucocorticoid response protein, MYOC, and GLC1A, is a protein that contains one olfactomedin-like domain. Myocilin / MYOC may participate in the obstruction of fluid outflow in the trabecular meshwork. Myocilin / MYOC is expressed in large amounts in various types of muscle, ciliary body, papillary sphincter, skeletal muscle, heart, and other tissues. Myocilin / MYOC is expressed predominantly in the retina. In normal eyes, it is found in the ...
TMPY-02133 Carbonic Anhydrase VB Protein, Human, Recombinant (His)

carbonic anhydrase VB, mitochondrial,CA-VB,MGC39962

Human E. coli
Carbonic anhydrase 5B, also known as carbonate dehydratase VB, carbonic anhydrase VB, CA-VB and CA5B, is amember of the alpha-carbonic anhydrase family. The strongest expression of CA5B / CA-VB is in heart, pancreas, kidney, placenta, lung, and skeletal muscle. It is not expressed in liver. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological process...
TMPJ-00990 S100B Protein, Mouse, Recombinant (His)

S-100 protein subunit beta,S-100 protein beta chain,S100b,S1...

Mouse E. coli
S100-B, is an acidic protein with a molecular weight of 21 kDa belonging to the S100 family. S100-B contains two EF-hand-type calcium-binding motifs separated by a hinge region with a hydrophobic cleft. S100-B plays an important role in neurodevelopment, differentiation, and brain construction. S100-B has neuroprotective effects, but at high concentrations S100-B is neurotoxic. Extracellular concentration of S100-B increases following brain damage, which easily penetrates into cerebrospinal flui...
TMPY-01992 Kallikrein 8/KLK8 Protein, Human, Recombinant (His)

kallikrein-related peptidase 8,PRSS19,TADG14,NRPN,NP,HNP

Human HEK293 Cells
Kallikrein-8, also known as Neuropsin, Serine protease 19, Serine protease TADG-14, Tumor-associated differentially expressed gene 14 protein, and KLK8 is a secreted protein that belongs to the peptidase S1 family and Kallikrein subfamily. It is a serine protease that is capable of degrading some proteins such as casein, fibrinogen, kininogen, fibronectin, and collagen type IV. Kallikrein-8 / KLK8 plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-c...
TMPY-01644 Cystatin S Protein, Human, Recombinant (His)

MGC71923,cystatin S,CST4

Human HEK293 Cells
Cystatin-S, also known as Cystatin-4, Salivary acidic protein 1, Cystatin-SA-III and CST4, is a secreted protein which belongs to thecystatin family. Cystatin-4 / CST4 is expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). It is also expressed in saliva, tears, urine and seminal fluid. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while oth...
TMPY-04467 NME1 Protein, Human, Recombinant (His)

NME/NM23 nucleoside diphosphate kinase 1,NB,NDPK-A,NM23-H1,N...

Human E. coli
NME1, also known as Nucleoside Diphosphate Kinase A (NDK-A), or NM23-H1, belongs to the NDK family. NM23-H1 is known to have a metastasis suppressive activity in many tumor cells. Recent studies have shown that the interacting proteins with NM23-H1 which mediate cell proliferation, may act as modulators of the metastasis suppressor activity. The interacting proteins with NM23-H1 can be classified into 3 groups. The first group of proteins can be classified as upstream kinases of NM23-H1 such as ...
TMPY-01466 S100A12 Protein, Human, Recombinant

MRP6,MRP-6,S100A12,S100 calcium binding protein A12,CAGC,p6,...

Human E. coli
S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S100 proteins have been implicated in a variety of i...
TMPY-01761 Carbonic Anhydrase 3 Protein, Human, Recombinant (His)

carbonic anhydrase III,CAIII,Car3

Human E. coli
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. Carbonic anhydrases (CAs) form a family of enzymes that catalyze the rapid conversion of carbon dioxide and water to bicarbonate an...

重组蛋白

PLA2G2A Protein, Mouse, Recombinant (His)
Cat.No: TMPY-04912
Species: Mouse
Expression System: P. pastoris (Yeast)
PLA2G2A Protein, Human, Recombinant (His)
Cat.No: TMPY-01705
Species: Human
Expression System: HEK293 Cells
PIP Protein, Human, Recombinant (His)
Cat.No: TMPH-01916
Species: Human
Expression System: E. coli
B2M/beta 2-Microglobulin Protein, Human, Recombinant (hFc)
Cat.No: TMPK-00019
Species: Human
Expression System: HEK293 Cells
VDB Protein, Human, Recombinant (His)
Cat.No: TMPJ-00759
Species: Human
Expression System: HEK293 Cells
GUCY2C Protein, Canine, Recombinant (aa 21-430, His)
Cat.No: TMPK-01388
Species: Canine
Expression System: HEK293 Cells
GUCY2C Protein, Mouse, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-00991
Species: Mouse
Expression System: HEK293 Cells
GUCY2C Protein, Cynomolgus, Recombinant (aa 24-430, His)
Cat.No: TMPK-01279
Species: Cynomolgus
Expression System: HEK293 Cells
GUCY2C Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00856
Species: Human
Expression System: HEK293 Cells
Serpin A5 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00490
Species: Human
Expression System: HEK293 Cells
GUCY2C Protein, Mouse, Recombinant (His & Avi)
Cat.No: TMPK-00990
Species: Mouse
Expression System: HEK293 Cells
BPIFA1/LUNX Protein, Human, Recombinant
Cat.No: TMPK-01201
Species: Human
Expression System: E. coli
GUCA2B Protein, Human, Recombinant (His)
Cat.No: TMPH-01424
Species: Human
Expression System: HEK293 Cells
Proteoglycan 4 Protein, Human, Recombinant (His)
Cat.No: TMPH-01973
Species: Human
Expression System: P. pastoris (Yeast)
PTH Protein, Human, Recombinant
Cat.No: TMPJ-00740
Species: Human
Expression System: E. coli
Follistatin 288 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00227
Species: Human
Expression System: HEK293 Cells
Carbonic Anhydrase 11 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00701
Species: Human
Expression System: HEK293 Cells
CHI3L2 Protein, Human, Recombinant (His)
Cat.No: TMPY-01933
Species: Human
Expression System: HEK293 Cells
LCN1 Protein, Human, Recombinant (His)
Cat.No: TMPY-01679
Species: Human
Expression System: HEK293 Cells
CA5A Protein, Human, Recombinant (His)
Cat.No: TMPY-01877
Species: Human
Expression System: E. coli
Carbonic Anhydrase 7 Protein, Human, Recombinant (His)
Cat.No: TMPY-02277
Species: Human
Expression System: E. coli
PHYH Protein, Human, Recombinant
Cat.No: TMPY-03109
Species: Human
Expression System: E. coli
AMBP Protein, Human, Recombinant (His)
Cat.No: TMPJ-00234
Species: Human
Expression System: HEK293 Cells
PTX3 Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-00981
Species: Mouse
Expression System: HEK293 Cells
Cystatin SN Protein, Human, Recombinant (His)
Cat.No: TMPY-02070
Species: Human
Expression System: HEK293 Cells
PDE2A Protein, Human, Recombinant (aa 215-900, His)
Cat.No: TMPY-02081
Species: Human
Expression System: Baculovirus Insect Cells
PTH Protein, Human, Recombinant (His)
Cat.No: TMPJ-00741
Species: Human
Expression System: HEK293 Cells
Adrenomedullin Protein, Human, Recombinant (hFc)
Cat.No: TMPY-02839
Species: Human
Expression System: HEK293 Cells
GBP1 Protein, Human, Recombinant (His)
Cat.No: TMPY-02549
Species: Human
Expression System: HEK293 Cells
CALCB Protein, Human, Recombinant (mFc)
Cat.No: TMPY-03963
Species: Human
Expression System: HEK293 Cells
Myocilin Protein, Human, Recombinant (His)
Cat.No: TMPY-02248
Species: Human
Expression System: HEK293 Cells
Carbonic Anhydrase VB Protein, Human, Recombinant (His)
Cat.No: TMPY-02133
Species: Human
Expression System: E. coli
S100B Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-00990
Species: Mouse
Expression System: E. coli
Kallikrein 8/KLK8 Protein, Human, Recombinant (His)
Cat.No: TMPY-01992
Species: Human
Expression System: HEK293 Cells
Cystatin S Protein, Human, Recombinant (His)
Cat.No: TMPY-01644
Species: Human
Expression System: HEK293 Cells
NME1 Protein, Human, Recombinant (His)
Cat.No: TMPY-04467
Species: Human
Expression System: E. coli
S100A12 Protein, Human, Recombinant
Cat.No: TMPY-01466
Species: Human
Expression System: E. coli
Carbonic Anhydrase 3 Protein, Human, Recombinant (His)
Cat.No: TMPY-01761
Species: Human
Expression System: E. coli
Cat. No. Product Name Target Signaling Pathways
T71329 Theophylline-d6

Theophylline-d6 is intended for use as an internal standard for the quantification of theophylline by GC- or LC-MS. Theophylline is an inhibitor of phosphodiesterase. It is also an adenosine A1 and A2 receptor antagonist. Theophylline induces relaxation of isolated cat bronchial smooth muscle segments precontracted with acetylcholine. It inhibits ovalbumin-induced increases in bronchoalveolar lavage fluid (BALF) eosinophil infiltration in an ovalbumin-sensitized mouse model of allergic asthma. F...
TMIJ-0376 D-Glucose-1,2-13C2

D-Glucose-1,2-13C2 是 D-Glucose 的 13C 的标记化合物。D-Glucose 的 CAS 号为 50-99-7。D-Glucose 是一种单糖。D-Glucose 是甜味剂,是一般代谢的关键组成部分,并作为与细胞代谢状态以及生物和非生物应激反应有关的关键信号分子。
T70186 Methazolamide-d6

Methazolamide-d6 is intended for use as an internal standard for the quantification of methazolamide by GC- or LC-MS. Methazolamide is a carbonic anhydrase inhibitor. It reduces intraocular pressure and cerebrospinal fluid flow in a rat model of glaucoma. Methazolamide reduces electroshock-induced seizures in rats with an ED50 value of 19.2 mg/kg. It also inhibits production of reactive oxygen species (ROS) in a primary cortical neuron (PCN) cellular model of subarachnoid hemorrhage (SAH) and re...
TMID-0097 Ethyl-d5-malonic Acid

Ethyl-d5-malonic Acid 是 Ethyl-malonic Acid 的氘代化合物。Ethyl-malonic Acid 的 CAS 号为 601-75-2。Ethylmalonic acid 是潜在有毒物质,非致癌性,与神经性厌食和甲氧基脱羧酶缺乏症有关。
T71303 Flufenamic Acid-d4

Flufenamic acid-d4 is intended for use as an internal standard for the quantification of flufenamic acid by GC- or LC-MS. Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 µM for human COX-1 and COX-2, respectively). Flufenamic acid inhibits TNF-α-induced increases in COX-2 levels and NF-κB activation in HT-29 colon cancer cells in a concentration-dependent manner. It inhibits calcium influx induced by fMLP or A23187 in human polymorphonuclear...

同位素标记化合物

Theophylline-d6
Cat.No: T71329
Synonym:
Target:
D-Glucose-1,2-13C2
Cat.No: TMIJ-0376
Synonym:
Target:
Methazolamide-d6
Cat.No: T70186
Synonym:
Target:
Ethyl-d5-malonic Acid
Cat.No: TMID-0097
Synonym:
Target:
Flufenamic Acid-d4
Cat.No: T71303
Synonym:
Target:
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