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Search Results for " factor-kb "

Targets Recommended: NF-κB

3

抑制剂 & 化合物

4

天然产物

1

化合物库

7

重组蛋白

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Cat. No.	Product Name
L3800	NF-κB 通路分子库		729 compounds
	729 个 NF-κB 信号通路相关的小分子化合物的特有集合，用于高通量、高内涵筛选；

化合物库

NF-κB 通路分子库

Cat.No: L3800

Compounds: 729

Cat. No.	Product Name	Target	Signaling Pathways
T39924	NF-κΒ activator 2	NF-κB	NF-κB
	NF-κΒ activator 2 是口服有效的 NF-ҡB 激活剂，EC50为 1.58 μM。它通过增加 NF-κB 的表达和激活来诱导 SOD2。它具有用于研究肌萎缩性侧索硬化症的价值。
T0947	Dexamethasone acetate Dexamethasone 21-acetate,醋酸地塞米松,Dexamethason acetate,NSC 39471	Glucocorticoid Receptor; Mitophagy; IL Receptor; Annexin A; NOS; Antibacterial; Autophagy; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Autophagy; Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology
	Dexamethasone acetate (NSC 39471) 是一种糖皮质素类甾体，有抗炎和免疫抑制活性。它可研究眼部感染。
T63107	Anti-inflammatory agent 6	Others	Others
	Anti-inflammatory agent 6 能够阻断作为炎症关键控制器的 Iκb 激酶 α/β（IKKα/β）、IκBα 和核因子 kB p65（NF-κb p65）的磷酸化，表现出抗炎潜力。

化合物

NF-κΒ activator 2

Cat.No: T39924

Target: NF-κB

Dexamethasone acetate

Cat.No: T0947

Synonym: Dexamethasone 21-acetate,醋酸地塞米松,Dexamethason acetate,NSC 39471

Target: Glucocorticoid Receptor, Mitophagy, IL Receptor, Annexin A, NOS, Antibacterial, Autophagy, ADC Cytotoxin

Anti-inflammatory agent 6

Cat.No: T63107

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T5660	Menthone	IL Receptor; TNF; NF-κB; Parasite	Apoptosis; Immunology/Inflammation; Microbiology/Virology; NF-κB
	Menthone 是一种从植物和薄荷油中提取的单萜，是精油的主要挥发性成分，具有抗炎和抗氧化特性。
T2745	18α-Glycyrrhetinic acid 18-α-甘草次酸,甘草次酸,Enoxolone,Glycyrrhetinic acid	Apoptosis; NF-κB; Proteasome	Apoptosis; NF-κB; Proteases/Proteasome; Ubiquitination
	18α-Glycyrrhetinic acid (Enoxolone) 是 NF-kB 的抑制剂和蛋白酶体的激活剂，在多细胞生物中起到促进长寿和抗聚集因子的作用。它诱导细胞凋亡。
TN1874	Liriodendrin 鹅掌楸苦素	ATPase; Potassium Channel; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel
	Liriodendrin 调节肺部炎症、NF-kB (p65) 的磷酸化和血管内皮生长因子 (VEGF) 的表达。Liriodendrin 具有抗炎、镇痛、降血糖活性，在脓毒症引起的急性肺损伤中起保护作用。
T37008	Reveromycin A	Others	Others
	Reveromycin A is the major component of a complex of spiroketal antibiotics isolated from Streptomyces sp. It inhibits the mitogenic activity of epidermal growth factor in Balb/MK cells (IC50 = 0.7 μg/ml), displays antiproliferative activity against human KB and K562 tumor cell lines (IC50s = 1.9 and 1.6 μg/ml, respectively), and demonstrates antifungal activity against C. albicans (MIC = 2 μg/ml at pH 3). Reveromycin A also has been shown to inhibit bone resorption by inducing apoptosis in oste...

天然产物

Cat.No: T5660

Target: IL Receptor, TNF, NF-κB, Parasite

18α-Glycyrrhetinic acid

Cat.No: T2745

Synonym: 18-α-甘草次酸,甘草次酸,Enoxolone,Glycyrrhetinic acid

Target: Apoptosis, NF-κB, Proteasome

Cat.No: TN1874

Synonym: 鹅掌楸苦素

Target: ATPase, Potassium Channel, Prostaglandin Receptor

Cat.No: T37008

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00674	RANK/TNFRSF11A Protein, Mouse, Recombinant (His) Receptor activator of NF-KB,TNFRSF11A,Osteoclast di...	Mouse	HEK293 Cells
	Receptor activator of NF-κB(RANK,TNFRSF11A) belongs to one member of tumor necrosis factor receptor family.It is a receptor for TNFSF11/RANKL/TRANCE/OPGL. This gene encodes a type 1 membrane protein with a 30 amino acids (aa) signal peptide, 184 aa extracellular region , a 20 aa transmembrane domain and a 391 aa cytoplasmic region. Human and murine RANK share 81% aa identity in their extracellular domains. RANK is ubiquitous highly expressed in trabecular bone, thymus, small intestine, lung, br...
TMPJ-00349	RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, His) CD265 antigen,FEO,TRANCER,ODFR,ODFROSTS,TRANCE R,TNFRSF11A,O...	Human	HEK293 Cells
	Receptor Activator of Nuclear Factor κ B (RANK), also known as CD265, TRANCE Receptor or TNFRSF11A, is member of the tumor necrosis factor receptor (TNFR) molecular superfamily. RANK is the receptor for RANK-Ligand (RANKL) and part of the RANK/RANKL/OPG signaling pathway that regulates osteoclast differentiation and activation. It plays a vital role in bone remodeling and repair, immune cell function, lymph node development, thermal regulation, and mammary gland development. RANK is constitutive...
TMPY-01710	IkB alpha/NFKBIA Protein, Human, Recombinant (His) IkB α,IKBA,nuclear factor of kapp...	Human	E. coli
	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkB alpha, NFKBIA, or IKBA), is a member of the NF-kappa-B inhibitor family that function to inhibit the NF-kB transcription factor. NFKBIA inhibits NF-kB by masking the nuclear localization signals (NLS) of NF-kB proteins and keeping them sequestered in an inactive state in the cytoplasm. Also, NFKBIA blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-kB's proper function...
TMPY-02757	TWEAKR/TNFRSF12A Protein, Human, Recombinant (hFc) FN14,CD266,TWEAKR,tumor necrosis factor receptor su...	Human	HEK293 Cells
	Fn14 (tumor necrosis factor receptor superfamily, member 12A), also known as TNFRSF12A, is the receptor for TNFSF12/TWEAK. Fn14 shares 82% amino acid identity with the mouse sequence. It contains a signal peptide, an extracellular domain, a membrane-anchoring domain, and a cytoplasmic domain. In response to FGF1, calf serum, or phorbol ester stimulation of human quiescent fibroblasts in vitro, the level of Fn14 is increased. A 1.2-kb FN14 transcript was expressed at high levels in heart, placent...
TMPH-02173	TRBC2 Protein, Human, Recombinant (His & Myc) T cell receptor beta constant 2,TRBC2	Human	E. coli
	Constant region of T cell receptor (TR) beta chain. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracell...
TMPH-02168	TRAC Protein, Human, Recombinant (E. coli, His) T cell receptor alpha chain constant,TRAC	Human	E. coli
	Constant region of T cell receptor (TR) alpha chain. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracel...
TMPH-02169	TRBC1 Protein, Human, Recombinant (His) T cell receptor beta constant 1,TRBC1	Human	P. pastoris (Yeast)
	Constant region of T cell receptor (TR) beta chain. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracell...

重组蛋白

RANK/TNFRSF11A Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00674

Species: Mouse

Expression System: HEK293 Cells

RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, His)

Cat.No: TMPJ-00349

Species: Human

Expression System: HEK293 Cells

IkB alpha/NFKBIA Protein, Human, Recombinant (His)

Cat.No: TMPY-01710

Species: Human

Expression System: E. coli

TWEAKR/TNFRSF12A Protein, Human, Recombinant (hFc)

Cat.No: TMPY-02757

Species: Human

Expression System: HEK293 Cells

TRBC2 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02173

Species: Human

Expression System: E. coli

TRAC Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-02168

Species: Human

Expression System: E. coli

TRBC1 Protein, Human, Recombinant (His)

Cat.No: TMPH-02169

Species: Human

Expression System: P. pastoris (Yeast)

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