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Search Results for " expansion "

Targets Recommended: Wnt/beta-catenin

30

抑制剂 & 化合物

2

天然产物

22

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T3635	IQ 1 IQ1,IQ-1	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	IQ 1 有多种作用，如保持小鼠ESCs 的多功能性、降低Wnt 刺激的磷酸化、阻止PP2A/Nkd 的相互作用等等。
T15199	Edicotinib JNJ-527,JNJ-40346527	c-Fms; FLT; CSF-1R; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	Edicotinib (JNJ-527) 是能够透过血脑屏障的、口服具有活性的、选择性的CSF-1R 抑制剂 (IC50:3.2 nM)。它对 KIT (IC50:20 nM) 和 FLT3 (IC50:190 nM) 的抑制作用较小。它抑制小胶质细胞的扩张，减弱小胶质细胞的增殖和神经退行性变。它可用于研究阿尔茨海默病和类风湿性关节炎。
T6506	FPH1 BRD-6125	Others	Others
	FPH1 (BRD-6125) 在体外能够提高人肝原代细胞的活性及数量，并促进 iPS 细胞向肝系分化。
T3590	NSC23005	CDK	Cell Cycle/Checkpoint
	NSC23005 是一种 p18INK 抑制剂，可有效促进造血干细胞 (HSC) 扩增 (ED50: 5.21 nM)。
T24580	P18IN003 P18IN 003,P18IN-003	CDK	Cell Cycle/Checkpoint
	P18IN003 是一种具有选择性和有效性的 p18(INK4C) 抑制剂，可抑制 p18 蛋白的活性可用于研究造血干细胞的体外扩增。
T3589	NSC23005 Sodium	CDK	Cell Cycle/Checkpoint
	NSC23005 sodium 是新型 p18 抑制剂 (ED50=5.21 nM)，在小鼠和人类模型中促进造血干细胞扩增。
T24398	Lenaldekar LDK	Akt; IGF-1R; S6 Kinase	Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Lenaldekar (LDK) 抑制 T 细胞扩增和自身免疫性脑脊髓炎。 Lenaldekar 导致 PI3 激酶/AKT/mTOR 通路成员的去磷酸化并延迟有丝分裂晚期的敏感细胞。
TQ0147	Arundic Acid ONO 2506,(R)-2-丙基辛酸,(R)-2-Propyloctanoic acid	Others	Others
	Arundic Acid (ONO 2506) 是星形胶质细胞调节剂，能够抑制 S-100β 的合成，并调节星形胶质细胞的活化，进而延缓脑梗塞的扩张。它对中风和阿尔茨海默病具有潜在的研究价值。
T77170	Siplizumab MEDI-507	Others	Others
	Siplizumab (MEDI-507) 是一种人源化靶向 CD2 的 IgG1 单克隆抗体。Siplizumab 在体外选择性地消耗效应记忆 T 细胞并促进同种异体反应性调节性 T 细胞的相对扩增。Siplizumab 可用于治疗斑块状银屑病。
T82525L	DT-2 acetate DT-2 acetate（1220985-78-3 Free base）	PKA	Tyrosine Kinase/Adaptors
	DT-2 acetate 是一种具有选择性的 cGMP 依赖性蛋白激酶 (PKG) 抑制剂，是一种靶向犬胸腺细胞的小鼠单克隆抗体。DT-2 acetate 抑制 PKG 催化的磷酸化，逆转8-Br-cGMP诱导的扩张，可用于研究免疫疾病。
T14973	CITCO	Apoptosis; Others	Apoptosis; Others
	CITCO 是一种咪唑噻唑衍生物，也是一种选择性组成型雄甾烷受体激动剂。它抑制脑肿瘤干细胞的生长和扩增，其 EC50 比孕烷 X 受体为 49 nM
T38861L	Tat-beclin 1 acetate Tat-beclin 1 acetate(1423821-88-8 free base)	HIV Protease; Autophagy	Autophagy; Microbiology/Virology; Proteases/Proteasome
	Tat-beclin 1 acetate 是一种有效的自噬诱导剂，并与自噬的负调节因子 GAPR-1 相互作用。 Tat-beclin 1 acetate 减少聚谷氨酰胺扩增蛋白聚集体的积累和几种病原体（包括 HIV-1）的复制。
T0048	Nikethamide N,N-Diethylnicotinamide,Corvotone,Anacardone,烟酰乙胺,Corvin	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Nikethamide 是呼吸中枢激活剂，可用于研究呼吸衰竭。
T29166	XIE18-6 XIE186	Others	Others
	XIE18-6, a novel INK4C inhibitor, specifically blocks the bioactivity of p18 protein and promotes human and murine hematopoietic stem cell ex vivo expansion.
T27279	ER819762 ER-819762,ER 819762	Others	Others
	ER819762, an antagonist of the prostaglandin E2 EP4 receptor, inhibits Th1 differentiation and Th17 expansion.
T32125	Hyperphyllin HP	Others	Others
	Hyperphyllin specifically mimics the branch defects of AMP1, including plastid reduction and expansion and proliferation of the branch meristem.
T71793	CDMG1	Others	Others
	CDMG1 is a novel Wnt inhibitor, promoting heart regeneration, injury repair, and myocardial hyperplasia through expansion of the cardiac progenitor cell population
T39650	Tadnersen IONIS-C9Rx,BIIB078	Others	Others
	Tadnersen (BIIB078) is an antisense oligonucleotide (ASO) designed for the selective targeting of C9ORF72 transcript variants 1 and 3, specifically those carrying the expansion.
T83072	Antifreeze Polypeptide 6 (winter flounder)
	Antifreeze Polypeptide 6 (winter flounder)为美洲拟鲽特有的抗冻多肽组成成分之一，主要作用是通过抑制冰核生长来降低血浆的凝固点。
T62859	MEIS-IN-1	Others	Others
	MEIS-IN-1 是一种有效的诱导小鼠和人类造血干细胞扩增的 MEIS 抑制剂。
T82642	Cyclo(RGDfK(Mal))
	Cyclo(RGDfK(Mal))为一种五肽，能促进人多能干细胞的附着与渗透，适用于三维干细胞培养及其扩增。
TP2001	MM 54
	Potent apelin receptor antagonist (Ki = 82 nM; IC50 = 93 nM). Antagonizes the inhibitory affect of [Pyr1]-Apelin-13 on forskolin-induced cAMP accumulation in CHO-K1-APJ cells. Recuces tumor expansion and lengthens survival time in a mouse xenograft model
T38861	Tat-beclin 1
	Tat-beclin 1, a peptide derived from the autophagy protein beclin 1, is a powerful inducer of autophagy. It interacts with GAPR-1 (GLIPR2), a negative regulator of autophagy. Tat-beclin 1 effectively reduces the buildup of polyglutamine expansion protein aggregates and inhibits the replication of various pathogens, such as HIV-1, in laboratory experiments. In addition, it has demonstrated the ability to decrease mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV).
T82560	di-Ellipticine-RIBOTAC	PROTACs	PROTAC
	Di-Ellipticine-RIBOTAC是一款双功能小分子，在体外和体内肌萎缩侧索硬化（ALS）模型中能够减少c9ALS/FTD r(G4C2)的重复扩增。
T83127	AMPK activator 13	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	AMPK activator13作为AMPK激活剂，通过激活AMPK通路有效抑制3T3-L1细胞的有丝分裂克隆扩增，并增加细胞线粒体耗氧量，适用于肥胖研究。
T62137	ANKRD22-IN-1	Others	Others
	ANKRD22-IN-1 是一种 ANKRD22 的有效抑制剂。ANKRD22-IN-1 能够促进胃肠黏膜上皮干细胞的扩增，进而可以间接激活 Wnt 经典通路，对体内受损胃肠黏膜组织的恢复有益。
T69308	Spliceostatin A	Apoptosis	Apoptosis
	Spliceostatin A 是抗癌剂和剪接抑制剂，抑制剪接体剪接机制，抑制有丝分裂克隆扩增和脂肪生成。Spliceostatin A 诱导细胞周期停滞在 G1 和 G2/M 期，诱导细胞凋亡。
T78031	MOG peptide (35-55)
	MOG peptide (35-55) 是一段特定的髓鞘少突胶质细胞糖蛋白 (MOG) 免疫原肽的35至55氨基酸序列。该肽段具有针对CD4+T细胞的特异性活性，并可用于诱导实验性自身免疫性脑脊髓炎 (EAE) 的动物模型。
T76058	Tat-beclin 1 TFA
	Tat-beclin 1 TFA是一种来源于自噬蛋白区域(beclin 1)的肽，有效诱导自噬(autophagy)并与GAPR-1 (GLIPR2)发生相互作用，具有显著的自噬负调控作用。该化合物能有效减少体外聚谷氨酰胺扩增蛋白聚集体的积累，并抑制HIV-1等多种病原体的复制。同时，Tat-beclin 1 TFA能显著降低感染基孔肯雅病(CHIKV)或西尼罗河病毒(WNV)小鼠的死亡率。
T36578	Boc-Lys(Ac)-AMC	Others	Others
	Commendamide (N-acyl-3-hydroxypalmitoyl-glycine) is a newly discovered GPCR G2A/GPR132 agonist (EC50=11.8 μM) that isolated from Bacteroides vulgatus. [1] G2A/GPR132 belongs to the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. GPR132/G2A is first reported to be a transcriptional target for BCR-ABL tyrosine kinase attenuating B-cell expansion in vitro and arresting cells at G2 during mitosis. It has been involved in autoimmune disease and atherosclerosis. [1]...

化合物

Cat.No: T3635

Synonym: IQ1,IQ-1

Target: Wnt/beta-catenin

Cat.No: T15199

Synonym: JNJ-527,JNJ-40346527

Target: c-Fms, FLT, CSF-1R, c-Kit

Cat.No: T6506

Synonym: BRD-6125

Target: Others

Cat.No: T3590

Target: CDK

Cat.No: T24580

Synonym: P18IN 003,P18IN-003

Target: CDK

NSC23005 Sodium

Cat.No: T3589

Target: CDK

Cat.No: T24398

Synonym: LDK

Target: Akt, IGF-1R, S6 Kinase

Cat.No: TQ0147

Synonym: ONO 2506,(R)-2-丙基辛酸,(R)-2-Propyloctanoic acid

Target: Others

Cat.No: T77170

Synonym: MEDI-507

Target: Others

Cat.No: T82525L

Synonym: DT-2 acetate（1220985-78-3 Free base）

Target: PKA

Cat.No: T14973

Target: Apoptosis, Others

Tat-beclin 1 acetate

Cat.No: T38861L

Synonym: Tat-beclin 1 acetate(1423821-88-8 free base)

Target: HIV Protease, Autophagy

Cat.No: T0048

Synonym: N,N-Diethylnicotinamide,Corvotone,Anacardone,烟酰乙胺,Corvin

Target: GABA Receptor

Cat.No: T29166

Synonym: XIE186

Target: Others

Cat.No: T27279

Synonym: ER-819762,ER 819762

Target: Others

Cat.No: T32125

Synonym: HP

Target: Others

Cat.No: T71793

Target: Others

Cat.No: T39650

Synonym: IONIS-C9Rx,BIIB078

Target: Others

Antifreeze Polypeptide 6 (winter flounder)

Cat.No: T83072

Cat.No: T62859

Target: Others

Cyclo(RGDfK(Mal))

Cat.No: T82642

Cat.No: TP2001

Cat.No: T38861

di-Ellipticine-RIBOTAC

Cat.No: T82560

Target: PROTACs

AMPK activator 13

Cat.No: T83127

Target: AMPK

Cat.No: T62137

Target: Others

Spliceostatin A

Cat.No: T69308

Target: Apoptosis

MOG peptide (35-55)

Cat.No: T78031

Tat-beclin 1 TFA

Cat.No: T76058

Boc-Lys(Ac)-AMC

Cat.No: T36578

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T2230	Paeoniflorin 芍药苷,Peoniflorin	HSP; COX	Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; Neuroscience
	Paeoniflorin (Peoniflorin) 是从芍药根中提取的一种蒎烷单萜糖苷，具有抗癌作用、抗氧化应激、抗血小板聚集、血管扩张、降低血液粘度和抗炎活性等多种生物活性。它是一种热休克蛋白诱导剂，通过自噬途径保护 PC12 细胞免受 MPP+和酸性损伤。
T3S1471	Cucurbitacin IIA 葫芦素Iia,Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA	Apoptosis; Survivin	Apoptosis
	Cucurbitacin IIA (Dihydrocucurbitacin Q1) 是从园果雪胆中分离得到的一种三萜烯，可诱导细胞凋亡和增强自噬，有助于葫芦素IIA 对炎症相关疾病的抗炎活性。它可降低癌细胞中生存素的表达，降低磷酸化组蛋白 H3 的水平，增加裂解的 PARP 的水平。

天然产物

Cat.No: T2230

Synonym: 芍药苷,Peoniflorin

Target: HSP, COX

Cucurbitacin IIA

Cat.No: T3S1471

Synonym: 葫芦素Iia,Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA

Target: Apoptosis, Survivin

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00580	Aquaporin Z Protein, E. coli, Recombinant (His) Water channel AqpZ,bniP,Aquaporin Z,Bacterial nodulin-like i...	E. coli	E. coli
	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. Aquaporin Z Protein, E. coli, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 27.7 kDa and the accession number is P60844.
TMPJ-00515	HCLS1 Protein, Human, Recombinant (His) p75,Hematopoietic cell-specific LYN substrate 1,LckBP1,Hemat...	Human	HEK293 Cells
	Hematopoietic lineage cell-specific protein (HCLS1) is a protein that in humans is encoded by the HCLS1 gene. It is expressed only in tissues and cells of hematopoietic origin. It is substrate of the antigen receptor-coupled tyrosine kinase and plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. It may also be involved in the regulation of gene expression.
TMPH-00754	Capsid decoration Protein, Escherichia phage lambda, Recombinant (GST) Gene product D,Auxiliary protein D,Major capsid protein D,gp...	Escherichia phage lambda	E. coli
	Stabilizes the expansion of the capsid head shell after genome packaging. The packaging of viral genome in the procapsid triggers a dramatic reconfiguration of the capsid shell, expanding from roughly 50nm to 60nm while the capsid thickness decreases. 415 capsid decoration protein molecules cooperatively bind the expanded capsid, thereby stabilizing the mature capsid shell. Capsid decoration Protein, Escherichia phage lambda, Recombinant (GST) is expressed in E. coli expression system with N-GST...
TMPY-00990	Lefty-A Protein, Human, Recombinant (hFc) LEFTYA,left-right determination factor 2,LEFTA,TGFB4,EBAF	Human	HEK293 Cells
	left-right determination factor 2 (Lefty2), also known as Left-right determination factor A (Lefty A), endometrial bleeding associated factor (left-right determination, factor A transforming growth factor-beta superfamily), and transforming growth factor beta-4, is a member of the TGF-beta family of proteins. This protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. Lefty2/Lefty A may also play a role in endometrial bleeding. Mutations i...
TMPJ-01196	ANGPTL8 Protein, Human, Recombinant (hFc) βtrophin,Angiopoietin-like protein 8,Lipasin,Angptl8,Betatro...	Human	HEK293 Cells
	The protein specifically promotes pancreatic beta cell proliferation and beta cell mass expansion, thereby improving glucose tolerance. It promotes pancreatic beta cell proliferation without insulin resistance. Also it acts as a blood lipid regulator by regulating serum triglyceride levels and possibly by promoting ANGPTL3 cleavage. It interacts with ANGPTL3. It predominantly expressed in liver and also expressed in adipose tissues. The ability of the protein to induce pancreatic beta cell proli...
TMPK-01226	DKK3 Protein, Human, Recombinant (His & Avi) AW061014,REIC,REICdkk-3,C87148,Dkk3,RIG,Dickkopf-3,RIG-like ...	Human	HEK293 Cells
	Dkk-3, also known as REIC (Reduced Expansion in Immortalized Cells), is one of four numbered members of the Dickkopf family of Wnt antagonists.DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. DKK3 Protein, Human, Recombinant (His & Avi) is expressed...
TMPK-01287	NCAM1 Protein, Cynomolgus, Recombinant (His) N-CAM-1,NCAM,MSK39,NCAM1,NCAM-1,CD56	Cynomolgus	HEK293 Cells
	Neural Cell Adhesion Molecule 1 (NCAM-1), a multifunctional member of the immunoglobulin superfamily, is expressed on the surface of neurons, glia, skeletal muscle, and natural killer cells. NCAM-1 has been implicated as having a role in cell-cell adhesion, involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. NCAM1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mam...
TMPK-00164	IL-2 R alpha/CD25 Protein, Human, Recombinant (His & Avi) IL-2 R alpha,IL-2 R α,IL2RA,IL2R,TCGFR,IDDM10,CD25,p55,IL-2 ...	Human	HEK293 Cells
	Human IL-2 receptor alpha (IL-2 R alpha), also known as Tac antigen and as CD25, was initially identified as a 55 kDa membrane glycoprotein that is capable of binding IL‑2.eceptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. IL-2 R alpha/CD25 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. ...
TMPK-01227	DKK3 Protein, Human, Recombinant (His & Avi), Biotinylated C87148,Dickkopf-3,Dkk3,RIG-like 7-1,AW061014,REIC,RIG,REICdk...	Human	HEK293 Cells
	Dkk-3, also known as REIC (Reduced Expansion in Immortalized Cells), is one of four numbered members of the Dickkopf family of Wnt antagonists.DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. DKK3 Protein, Human, Recombinant (His & Avi), Biotinylate...
TMPK-00165	IL-2 R alpha/CD25 Protein, Human, Recombinant (His & Avi), Biotinylated IL2RA,CD25,IL-2 R alpha,TCGFR,IL-2 R α/CD25,p55,IL-2 R α,IDD...	Human	HEK293 Cells
	Human IL-2 receptor alpha (IL-2 R alpha), also known as Tac antigen and as CD25, was initially identified as a 55 kDa membrane glycoprotein that is capable of binding IL‑2.eceptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. IL-2 R alpha/CD25 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C...
TMPJ-00824	Ig lambda constant 2 Protein, Human, Recombinant (His) Ig λ constant 2 Protein, Human, Recombinant (His),MGC45681,I...	Human	HEK293 Cells
	Immunoglobulin lambda constant region is constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. IGLC2 is 105 amino acids (aa) in length. I...
TMPK-00815	NCAM1 Protein, Human, Recombinant (aa 20-718, His) MSK39,CD56,NCAM1,N-CAM-1,NCAM-1,NCAM	Human	HEK293 Cells
	Neural Cell Adhesion Molecule 1 (NCAM-1), a multifunctional member of the immunoglobulin superfamily, is expressed on the surface of neurons, glia, skeletal muscle, and natural killer cells. NCAM-1 has been implicated as having a role in cell-cell adhesion, involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. NCAM1 Protein, Human, Recombinant (aa 20-718, His) is expressed in HEK2...
TMPK-00816	NCAM1 Protein, Mouse, Recombinant (aa 20-711, His) NCAM-1,NCAM,CD56,MSK39,NCAM1,N-CAM-1	Mouse	HEK293 Cells
	Neural Cell Adhesion Molecule 1 (NCAM-1), a multifunctional member of the immunoglobulin superfamily, is expressed on the surface of neurons, glia, skeletal muscle, and natural killer cells. NCAM-1 has been implicated as having a role in cell-cell adhesion, involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. NCAM1 Protein, Mouse, Recombinant (aa 20-711, His) is expressed in HEK2...
TMPY-02276	GPR56 Protein, Human, Recombinant (His) BFPP,UNQ540/PRO1083,DKFZp781L1398,TM7LN4,adhesion G protein-...	Human	HEK293 Cells
	ADGRG1 (Adhesion G Protein-Coupled Receptor G1, also known as GPR56) is a Protein Coding gene. GPR56 is a member of an adhesion G protein-coupled receptor family with a very long N-terminal stalk and seven transmembrane domains. The encoded protein binds specifically to transglutaminase 2, a component of tissue and tumor stroma implicated as an inhibitor of tumor progression. GPR56 may be a target for the treatment of type 2 diabetes. GPR56 inhibits melanoma metastatic growth by impeding the exp...
TMPJ-00439	BTNL6 Protein, Mouse, Recombinant (His) EG624681,BTNL6,NG13,Butyrophilin-like 6,Gm6519	Mouse	HEK293 Cells
	Butyrophilin-like 6 (BTNL6) is a member of the BTN/MOG Ig-superfamily and functions with BTNL1 as a regulator of immune cell proliferation. The Btnl6 gene is found only in mice. BTNL6 expression is coordinated as a heteromeric protein with BTNL1, and the presence of this complex is correlated with expansion of gamma δ T cells, especially those containing V gamma 7Vδ4 TCR. Btnl6 shows striking sequence similarity to Skint1; is also largely restricted to an epithelial tissue (the small intestine) ...
TMPJ-00968	NAMPT Protein, Human, Recombinant (His) PBEF,PBEF1,Nicotinamide phosphoribosyltransferase,NAmPRTase,...	Human	E. coli
	Pre-B cell colony enhancing factor (PBEF) was originally identified as a cytokine that potentiated the clonal expansion and differentiation of pre-B cells, but it is also acknowledged to be the ubiquitous intracellular enzyme nicotinamide phosphoribosyltranferase (NAMPT) and the adipokine “visfatin”. PBEF is constitutively expressed in the fetal membranes where its greatest expression is in the amnion. It has intracellular and extracellular forms. Most of the intracellular functions of PBEF are ...
TMPY-05028	NOTCH2NL Protein, Human, Recombinant (mFc) notch 2 N-terminal like,N2N	Human	HEK293 Cells
	NOTCH2NLA (Notch 2 N-Terminal Like A) is a Protein Coding gene. NOTCH2NL, human-specific paralogs of the NOTCH2 receptor, stood out for their ability to promote cortical progenitor maintenance. It belongs to the NOTCH family. NOTCH2NL promote the clonal expansion of human cortical progenitors, ultimately leading to higher neuronal output. At the molecular level, NOTCH2NL function by activating the Notch pathway through inhibition of cis Delta/Notch interactions. NOTCH2NL ectopic expression delay...
TMPY-01576	Artemin Protein, Mouse, Recombinant (hFc) artemin,neublastin	Mouse	HEK293 Cells
	Artemin (ARTN) is a member of glial cell line-derived neurotrophic factor (GDNF) family of ligands, and its signaling is mediated via a multi-component receptor complex including the glycosylphosphatidylinositol-anchored GDNF family receptors a (GFRa1, GFRa3) and RET receptor tyrosine kinase. The major mechanism of ARTN action is via binding to a non-signaling co-receptor. The major function of ARTN is to drive the molecule to induce migration and axonal projection from sympathetic neurons. It a...
TMPJ-00879	HOXB4 Protein, Human,Recombinant (L175D, E176K, E178K, His) Homeobox protein Hox-2.6,HOX2F,HOXB4,Homeobox protein Hox-2F...	Human	E. coli
	Homeobox B4 (HOXB4) is encoded by the HOXB4 gene which is a member of the the class I homeobox (HOX) gene family and encodes a nuclear protein with a homeobox DNA-binding domain. These genes are master control regulators of developmental programs including embryonic and adult hematopoiesis. Multiple HOX genes, including HOXB4, are highly expressed in the hematopoietic stem cells (HSC) compartment. HOXB4 gene can act in opposite ways when expressed by different cells, promoting the proliferation ...
TMPJ-00748	Ig kappa Protein, Human, Recombinant (His) Ig κ chain C region AG,Ig κ,Ig kappa chain C region AG,Ig ka...	Human	HEK293 Cells
	Immunoglobulin Kappa is constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humo...
TMPY-00819	HAPLN1 Protein, Human, Recombinant (His) CRTL1,hyaluronan and proteoglycan link protein 1	Human	HEK293 Cells
	Hyaluronan (HA) is a high MW glycosaminoglycan significantly involved in the formation and stability of extracellular matrix via its association with specific HA-binding proteins. HAPLN1, also known as CRTL1 (Cartilage Link Protein 1, CLP) and link protein, is a member of the HA-binding protein (hyaladherins) family, and contains a common structural domain of about 100 amino acids that is termed a Link module with two α-helices and two antiparallel β-sheets. HAPLN1/CRTL1 stabilizes the interacti...
TMPY-04550	JNK2 Protein, Human, Recombinant (His) JNK2α,SAPK1a,PRKM9,JNK2β,JNK2,SAPK,JNK2BETA,mitogen-activate...	Human	Baculovirus Insect Cells
	Mitogen-activated protein kinase 9 (MAPK9), also well known as c-Jun N-terminal kinase (JNK2), is a member of the MAP kinase subfamily belonging to the protein kinase superfamily. MAPK9 responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating some transcription factors, such as c-Jun and ATF2. The crystal structure of human JNK2 complexed with an indazole inhibitor by applying a high-throughput protein engineering and surface-site mutagenesis approach. A n...

重组蛋白

Aquaporin Z Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00580

Species: E. coli

Expression System: E. coli

HCLS1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00515

Species: Human

Expression System: HEK293 Cells

Capsid decoration Protein, Escherichia phage lambda, Recombinant (GST)

Cat.No: TMPH-00754

Species: Escherichia phage lambda

Expression System: E. coli

Lefty-A Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00990

Species: Human

Expression System: HEK293 Cells

ANGPTL8 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-01196

Species: Human

Expression System: HEK293 Cells

DKK3 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-01226

Species: Human

Expression System: HEK293 Cells

NCAM1 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01287

Species: Cynomolgus

Expression System: HEK293 Cells

IL-2 R alpha/CD25 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00164

Species: Human

Expression System: HEK293 Cells

DKK3 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-01227

Species: Human

Expression System: HEK293 Cells

IL-2 R alpha/CD25 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00165

Species: Human

Expression System: HEK293 Cells

Ig lambda constant 2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00824

Species: Human

Expression System: HEK293 Cells

NCAM1 Protein, Human, Recombinant (aa 20-718, His)

Cat.No: TMPK-00815

Species: Human

Expression System: HEK293 Cells

NCAM1 Protein, Mouse, Recombinant (aa 20-711, His)

Cat.No: TMPK-00816

Species: Mouse

Expression System: HEK293 Cells

GPR56 Protein, Human, Recombinant (His)

Cat.No: TMPY-02276

Species: Human

Expression System: HEK293 Cells

BTNL6 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00439

Species: Mouse

Expression System: HEK293 Cells

NAMPT Protein, Human, Recombinant (His)

Cat.No: TMPJ-00968

Species: Human

Expression System: E. coli

NOTCH2NL Protein, Human, Recombinant (mFc)

Cat.No: TMPY-05028

Species: Human

Expression System: HEK293 Cells

Artemin Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-01576

Species: Mouse

Expression System: HEK293 Cells

HOXB4 Protein, Human,Recombinant (L175D, E176K, E178K, His)

Cat.No: TMPJ-00879

Species: Human

Expression System: E. coli

Ig kappa Protein, Human, Recombinant (His)

Cat.No: TMPJ-00748

Species: Human

Expression System: HEK293 Cells

HAPLN1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00819

Species: Human

Expression System: HEK293 Cells

JNK2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04550

Species: Human

Expression System: Baculovirus Insect Cells

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