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Targets Recommended: Estrogen/progestogen Receptor Estrogen Receptor/ERR Estrogen Receptor/ERR

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Cat. No. Product Name
L2191 抗乳腺癌化合物库

1939 compounds
1939 种与乳腺癌相关的化合物，可以用于抗乳腺癌药物研发和药理研究；

化合物库

抗乳腺癌化合物库
Cat.No: L2191
Compounds: 1939
Cat. No. Product Name Target Signaling Pathways
T15249 Estrogen receptor modulator 1

Estrogen Receptor/ERR Endocrinology/Hormones
Estrogen receptor modulator 1 是一种有效的、具有口服活性的、选择性雌激素受体(estrogen receptor)调节剂 (SERM)，其 pIC50为 0.46。它能够诱导 Tamoxifen 耐药、激素非依赖性异种移植瘤的消退。
T78646 Estrogen receptor antagonist 8

Estrogen/progestogen Receptor Endocrinology/Hormones
Estrogen receptor antagonist 8 作为一种雌激素受体(ER)拮抗剂，具有抗子宫活性和潜在的抗肿瘤活性，可用于研究卵巢功能障碍。
T11236 Giredestrant tartrate

Estrogen receptor antagonist 1

 Estrogen Receptor/ERR; Others Endocrinology/Hormones; Others
Giredestrant tartrate (Estrogen receptor antagonist 1) 是一种新型的、具有口服活性的、有选择性的、有效的的非甾体雌激素受体拮抗剂。Giredestrant tartrate 与 ER 强效结合，导致 ER 无法激活靶向基因的转录，并促使 ER 蛋白降解。Giredestrant tartrate 可用于治疗肿瘤疾病。
T11237 Camizestrant

Estrogen receptor antagonist 2

 Estrogen Receptor/ERR Endocrinology/Hormones
Camizestrant (Estrogen receptor antagonist 2) 是一种雌激素受体拮抗剂，可用于 ER+ HER2 晚期乳腺癌的研究[1]。
T40893 Estrogen receptor modulator 6

Others Others
Estrogen receptor modulator 6 (compound 3a) is a highly specific and potent agonist of the estrogen receptor (ER) β with a remarkable affinity (K i = 0.44 nM). This compound exhibits an impressive 19-fold selectivity for ERβ over ERα, as evidenced by its affinity (K i = 8.4 nM).
T19988 Conjugated Estrogen sodium

Conjugated estrogens,Conest,HSDB 3076,Kestrin,Estrogens, conjugated,TAG-39

 Others Others
Conjugated estrogens are medicine that contains a mixture of estrogen hormones. It is used to treat moderate to severe hot flashes, changes in and around the vagina, and other symptoms of menopause or low amounts of estrogen. Conjugated estrogens tablet i
T60293 Estrogen receptor-IN-1

Others Others
Estrogen receptor-IN-1 (compound 16) 是有效的雌激素受体(ER)抑制剂，其对 ERα 和 Erβ 的IC50值分别为 13 和 5μM。
T63582 Estrogen receptor antagonist 1

Others Others
Estrogen receptor antagonist 1 是 estrogen receptor 的有效拮抗剂。其中雌激素 (E2) 和雌激素α受体 (ERα) 是乳腺癌发展的重要驱动因素。Estrogen receptor antagonist 1 对乳腺癌疾病表现出研究潜力。
T79064 Estrogen receptor modulator 7

Estrogen Receptor/ERR Endocrinology/Hormones
Estrogen receptor modulator7 为一高效雌激素受体调节剂，主要用途涉及癌症研究领域。
T62953 Estrogen receptor antagonist 6

Others Others
Estrogen receptor antagonist 6 是一种 Estrogen receptor 的有效拮抗剂。雌激素受体 (Estrogen receptor) 是一种配体激活的转录调节蛋白，能够与内源性雌激素的相互作用，并介导多种生物效应的诱导。Estrogen receptor antagonist 6 具有潜力进行转移性疾病的研究。
T63277 Estrogen receptor antagonist 2

Others Others
Estrogen receptor antagonist 2 是 estrogen receptor 的选择性下调剂。雌激素 (E2) 和雌激素 α 受体 (ERα) 是乳腺癌发展的重要驱动因素。Estrogen receptor antagonist 2 对乳腺癌疾病具有研究潜力。
T62952 Estrogen receptor antagonist 5

Others Others
Estrogen receptor antagonist 5 是一种 Estrogen receptor 的有效拮抗剂。雌激素受体 (Estrogen receptor) 是一种配体激活的转录调节蛋白，能够与内源性雌激素的相互作用，并介导多种生物效应的诱导。Estrogen receptor antagonist 5 具有潜力进行转移性疾病的研究。
T61909 Estrogen receptor antagonist 7

Others Others
Estrogen receptor antagonist7 (compound 13) 是高效ER拮抗剂，能够抑制乳腺癌细胞与卵巢癌细胞生长，展现出抗癌及抗子宫营养活性。
T63914 Estrogen receptor antagonist 3

Others Others
Estrogen receptor antagonist 3 是雌激素受体 (ER) 的有效降解剂。雌激素信号系统在调节细胞生长、分化和凋亡 (apoptosis) 中发挥着重要作用。Estrogen receptor antagonist 4 对癌症疾病表现出研究潜力。
T63106 Estrogen receptor antagonist 4

Others Others
Estrogen receptor antagonist4 是一种有效的雌激素受体 (ER) 降解剂。雌激素信号系统在调节细胞生长、分化和凋亡 (apoptosis) 中发挥着重要作用。Estrogen receptor antagonist4 具有研究癌症疾病的潜力。
T79109 Estrogen receptor modulator 8

Estrogen Receptor/ERR Endocrinology/Hormones
Estrogen receptor modulator8 (compound 4) 为一口服活性化合物，作用为抑制雌激素受体/ERR α（IC50=0.437 nM，MCF-7 细胞）。此化合物能有效抑制MCF-7细胞的增殖，其IC50值仅为0.1 nM。
T82439 Estrogen receptor modulator 10

Estrogen Receptor/ERR Endocrinology/Hormones
Estrogen receptor modulator10 (compound G-5b) 是一种具有高亲和力的ER拮抗剂，具有IC50值为6.7 nM，并且是一种有效的降解剂，DC50为0.4 nM。它能够通过蛋白酶体途径实现对ER的快速降解，并能诱导细胞凋亡，同时还能将细胞周期阻滞在G1/G0期，这使其成为癌症研究中的一个重要工具。
T62764 Estrogen receptor α antagonist 1

Others Others
Estrogen receptor α antagonist 1 (compound 35) 是一种高度选择性的 estrogen receptor α 拮抗剂，作用于 estrogen receptor α (IC50: 0.02 μM)，estrogen receptor β (IC50: 6.55 μM) 和 MCF-7 细胞 (IC50: 7.73 μM)。Estrogen receptor α antagonist 1 (compound 35) 能够用于研究肿瘤。
T62311 Estrogen receptor β antagonist 2

Others Others
Estrogen receptor β antagonist 2 是一种选择性的、有效的雌激素受体βestrogen receptor β (ERβ) 拮抗剂，作用于 Erα (IC50: 109.10 μM)和 Erβ (IC50: 0.63 μM)。
T4388 PHTPP

Estrogen Receptor/ERR; Estrogen/progestogen Receptor Endocrinology/Hormones
PHTPP 是选择性的雌激素受体 β 拮抗剂，其选择性比 ERα 高 36 倍。
T8984 FLTX1

Estrogen Receptor/ERR; Estrogen/progestogen Receptor Endocrinology/Hormones
FLTX1 is a fluorescent derivative of Tamoxifen, designed to efficiently target and label intracellular Tamoxifen-binding sites (estrogen receptors) both under permeabilized and non-permeabilized conditions. Additionally, FLTX1 demonstrates strong antiestrogenic activity in breast cancer cells, resembling the potent antiestrogenic properties of Tamoxifen. Notably, FLTX1 does not exhibit any estrogenic agonistic effect on the uterus.
T7904 SR 19881

Estrogen/progestogen Receptor Endocrinology/Hormones
SR 19881 是 ERRγ 的完全激动剂（结合试验中的 EC50 值为 0.39 μM，基于细胞的试验中 EC50 值为 4.7 μM）。
T7644 DPN

Diarylpropionitrile,2,3-双(4-羟苯基)丙腈

 Apoptosis; Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Autophagy Apoptosis; Autophagy; Endocrinology/Hormones
DPN (Diarylpropionitrile) 是一种非甾体雌激素受体 ERβ选择性配体，其 EC50值为 0.85 nM。DPN 在许多神经系统疾病具有神经保护作用。
T3975 AZD9496

Estrogen Receptor/ERR; Estrogen/progestogen Receptor Endocrinology/Hormones
AZD9496 是口服有效的选择性雌激素受体降解剂，是一种选择性的雌激素受体拮抗剂(IC50:0.28 nM)。
T7389 G15

Estrogen Receptor/ERR Endocrinology/Hormones
G15 是一种高亲和力的、选择性的 G 蛋白偶联雌激素受体(GPER/GPR30)拮抗剂(Ki:20 nM)。
T39710 ARV-471

Vepdegestrant

 Estrogen Receptor/ERR; PROTACs Endocrinology/Hormones; PROTAC
ARV-471 (Vepdegestrant) 是一种高效的，口服有效的基于 Cereblon 配体的雌激素受体降解剂 PROTAC 。ARV-471 常用于研究乳腺癌。
T5531 GSK-4716

Estrogen Receptor/ERR Endocrinology/Hormones
GSK-4716 是一种ERRβ/γ选择性激动剂。
T6533 Hexestrol

Bibenzyl,4,4'-(1,2-二乙基亚乙基)二苯酚,Hexanoestrol,meso-Hexestrol,Hexestrofen

 Estrogen Receptor/ERR; Estrogen/progestogen Receptor Endocrinology/Hormones
Hexestrol (Hexanoestrol) 是非甾体合成雌激素，对雌激素受体ERα和ERβ的Ki=均为 0.06 nM。它可增加牛的体重，也可用于雌激素缺乏引起的疾病的研究。
T16566 Propyl pyrazole triol

PPT

 Estrogen Receptor/ERR; Estrogen/progestogen Receptor Endocrinology/Hormones
Propyl pyrazole triol (PPT) 是雌激素受体 α(ERα)选择性激动剂。它对 ERα 的相对结合亲和力 (ERα: 49%) 比雌激素受体 β (ERβ: 0.12%) 高 410 倍。
T14987 CMP8

Estrogen Receptor/ERR; Estrogen/progestogen Receptor Endocrinology/Hormones
CMP8 是一种雌激素受体的选择性配体，可结合到雌激素受体配体结合域。它能够作用于突变型 MGERα (IC50:29 nM)、MGRERα (IC50:41 nM)和野生型 hERα (IC50:1100 nM)、hERβ (IC50:2200 nM)。
T1216 Diethylstilbestrol

Stilbestrol,己烯雌酚,DES

 Estrogen Receptor/ERR; Estrogen/progestogen Receptor Endocrinology/Hormones
Diethylstilbestrol (DES) 是一种非甾体雌性激素，能够用于更年期和绝经后的紊乱。
T15364 G-1

Estrogen Receptor/ERR; GPR Endocrinology/Hormones; GPCR/G Protein
G-1 是一种高亲和力的、非甾体的、有选择性的 GPR30激动剂(Ki:11 nM)。
T5633 H3B-5942

Estrogen Receptor/ERR; Estrogen/progestogen Receptor Endocrinology/Hormones
H3B-5942 是不可逆的、选择性的、可口服的雌激素受体共价拮抗剂，能够靶作用于 Cys530，使野生型和突变型ERα失活，能够抑制 ERα 的目标基因GREB1的表达。它具有抗癌活性，对含有 ERαWT 或者突变型 ERα 的肿瘤细胞和动物具有抗肿瘤作用。
T0593 XCT790

Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Autophagy Autophagy; Endocrinology/Hormones
XCT790 是 ERRα的一种选择性反向激动剂，IC50值为 0.37 μM。它在化疗过程中诱导癌细胞死亡。
T3958 WAY-200070

WAY 200070

 Estrogen Receptor/ERR; Estrogen/progestogen Receptor Endocrinology/Hormones
WAY-200070 是一种选择性的雌激素受体激动剂(IC50:2.3 nM)。
T20625 Prochloraz

咪鲜胺,Sporgon,Prelude

 Estrogen Receptor/ERR; AhR; Androgen Receptor; Antifungal Endocrinology/Hormones; Immunology/Inflammation; Metabolism; Microbiology/Virology
Prochloraz (Prelude) 是咪唑类抗真菌剂。Prochloraz 抑制羊毛甾醇的细胞色素 P450 依赖性 14α-脱甲基作用，由此抑制麦角固醇的生物合成，从而导致真菌细胞膜破裂和细胞死亡。它也是雌激素受体和 雄激素受体的拮抗剂，IC50分别为25 μM 和4 μM， 并激活芳烃受体，EC50为1μM。
T6306 Erteberel

LY500307

 Estrogen Receptor/ERR; Estrogen/progestogen Receptor Endocrinology/Hormones
Erteberel (LY500307) 是一种选择性的雌激素受体 β(ERβ) 激动剂，其Ki=1.54 nM，EC50=3.61 nM。具有抗肿瘤作用。
T8370 GSK5182

Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Reactive Oxygen Species Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB
GSK5182 是高效选择性，具有口服活性的 ERRγ反向激动剂，其 IC50=79 nM，且不与其他核受体相互作用，包括 ERRα 和 ERα。它还能增加肝癌细胞中 reactive oxyen species (ROS)的产生。
T13674 Elacestrant

依拉司群,RAD1901

 Estrogen Receptor/ERR; Estrogen/progestogen Receptor Endocrinology/Hormones
Elacestrant (RAD1901) 是一种具有口服活性的、选择性的雌激素受体 (ER) 降解剂 (SERD)，能够作用于 ERα (IC50:48 nM)和 ERβ (IC50:870 nM)。
T13443 (R)-Equol

(+)-Equol,R-雌马酚

 Estrogen/progestogen Receptor Endocrinology/Hormones
(R)-Equol ((+)-Equol) 是一种 ERα (Ki:27.4 nM) 和 Erβ (Ki:15.4 nM) 激动剂。
T13507 4,4'-Iminodiphenol

4-(4-羟基苯胺)苯酚,Leucoindophenol

 Estrogen/progestogen Receptor Endocrinology/Hormones
4,4'-Iminodiphenol (Leucoindophenol) 是基于二苯胺骨架的无活性雌激素受体配体。
T0168 Estradiol (cypionate)

Depofemin,环戊丙酸雌二醇,Estradiol cypionate

 Estrogen Receptor/ERR; Estrogen/progestogen Receptor Endocrinology/Hormones
Estradiol cypionate (Depofemin) 是一种 Estradiol 的 17β-环戊丙酸酯，能够作用于雌激素受体。抑制ET-1的合成。
T0035 Dienestrol

Restrol,双烯雌酚,Dehydrostilbestrol,Dienoestrol,Cycladiene

 Estrogen Receptor/ERR; Estrogen/progestogen Receptor Endocrinology/Hormones
Dienestrol (Restrol) 是一种雌激素受体激动剂，是一种合成的非甾体类雌激素，用于对绝经期和绝经后症状的相关研究。
T7313 Enclomiphene citrate

恩氯米芬柠檬酸盐,Enclomifene citrate,(E)-Clomiphene citrate,trans-Clomiphene citrate

 Estrogen Receptor/ERR Endocrinology/Hormones
Enclomiphene citrate (trans-Clomiphene citrate) 是口服具有活力的 oestrogen receptor 拮抗剂，具有抗雌激素活性。
T7223 Gestrinone

R 2323,孕三烯酮

 Estrogen Receptor/ERR; Estrogen/progestogen Receptor Endocrinology/Hormones
Gestrinone (R 2323) 是一种合成类固醇激素，能够抑制平滑肌瘤(IC50:43.67 μM)，有用于子宫内膜异位症的研究潜力。
T6404 Bazedoxifene hydrochloride

Bazedoxifene HCl,盐酸巴多昔芬,TSE-424

 Estrogen Receptor/ERR; Estrogen/progestogen Receptor Endocrinology/Hormones
Bazedoxifene hydrochloride (TSE-424) 是一种 IL-6/GP130蛋白相互作用抑制剂，可用于胰腺癌的研究。它也是一种有口服活性的，能透过血脑屏障的，非甾体、选择性的雌激素受体调节剂 (SERM)，对 ERα 和 ERβ 作用的 IC50值分别为 26 nM 和 99 nM，可用于研究骨质疏松症。
T8981 WAY-169916

WAY 169916,WAY169916

 NF-κB NF-κB
WAY-169916 是雌激素受体 (ER) 的通路选择性抑制剂。它通过抑制 NF-kB 转录活性而发挥作用，但没有常规的雌激素活性。
T4420 4-Hydroxytamoxifen

ICI 79280,(Z)-4-hydroxy Tamoxifen,4-羟基他莫昔芬,trans-4-Hydroxytamoxifen

 Estrogen Receptor/ERR; Estrogen/progestogen Receptor Endocrinology/Hormones
4-Hydroxytamoxifen (ICI 79280) 是 Tamoxifen 的活性代谢产物，是一种雌激素受体调节剂 (SERM)，具有选择性和口服有效性。4-Hydroxytamoxifen 具有抗肿瘤活性，可用于乳腺癌的研究。
T2567 Etonogestrel

3-Oxodesogestrel,3-keto-Desogestrel,依托孕烯,Nexplanon,Implanon

 Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Progesterone Receptor; Endogenous Metabolite Endocrinology/Hormones; Metabolism; Others
Etonogestrel (Implanon) 是孕激素去氧孕烯的生物活性代谢物，与靶器官中的孕酮受体和雌激素受体高亲和力地结合，可诱导FKBP51mRNA 和蛋白表达。它是一种甾体孕激素，用作激素避孕药。
T0384 Estradiol benzoate

Benzoestrofol,Benzhormovarine,苯甲酸雌二醇,Benovocylin

 Estrogen Receptor/ERR; Estrogen/progestogen Receptor Endocrinology/Hormones
Estradiol benzoate (Benzhormovarine) 是一种类固醇性激素，是一种雌二醇的前体药物。它表现出轻微的合成代谢特性，增加血液凝固性。

化合物

Estrogen receptor modulator 1
Cat.No: T15249
Synonym:
Target: Estrogen Receptor/ERR
Estrogen receptor antagonist 8
Cat.No: T78646
Synonym:
Target: Estrogen/progestogen Receptor
Giredestrant tartrate
Cat.No: T11236
Synonym: Estrogen receptor antagonist 1
Target: Estrogen Receptor/ERR, Others
Camizestrant
Cat.No: T11237
Synonym: Estrogen receptor antagonist 2
Target: Estrogen Receptor/ERR
Estrogen receptor modulator 6
Cat.No: T40893
Synonym:
Target: Others
Conjugated Estrogen sodium
Cat.No: T19988
Synonym: Conjugated estrogens,Conest,HSDB 3076,Kestrin,Estrogens, conjugated,TAG-39
Target: Others
Estrogen receptor-IN-1
Cat.No: T60293
Synonym:
Target: Others
Estrogen receptor antagonist 1
Cat.No: T63582
Synonym:
Target: Others
Estrogen receptor modulator 7
Cat.No: T79064
Synonym:
Target: Estrogen Receptor/ERR
Estrogen receptor antagonist 6
Cat.No: T62953
Synonym:
Target: Others
Estrogen receptor antagonist 2
Cat.No: T63277
Synonym:
Target: Others
Estrogen receptor antagonist 5
Cat.No: T62952
Synonym:
Target: Others
Estrogen receptor antagonist 7
Cat.No: T61909
Synonym:
Target: Others
Estrogen receptor antagonist 3
Cat.No: T63914
Synonym:
Target: Others
Estrogen receptor antagonist 4
Cat.No: T63106
Synonym:
Target: Others
Estrogen receptor modulator 8
Cat.No: T79109
Synonym:
Target: Estrogen Receptor/ERR
Estrogen receptor modulator 10
Cat.No: T82439
Synonym:
Target: Estrogen Receptor/ERR
Estrogen receptor α antagonist 1
Cat.No: T62764
Synonym:
Target: Others
Estrogen receptor β antagonist 2
Cat.No: T62311
Synonym:
Target: Others
PHTPP
Cat.No: T4388
Synonym:
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
FLTX1
Cat.No: T8984
Synonym:
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
SR 19881
Cat.No: T7904
Synonym:
Target: Estrogen/progestogen Receptor
DPN
Cat.No: T7644
Synonym: Diarylpropionitrile,2,3-双(4-羟苯基)丙腈
Target: Apoptosis, Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Autophagy
AZD9496
Cat.No: T3975
Synonym:
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
G15
Cat.No: T7389
Synonym:
Target: Estrogen Receptor/ERR
ARV-471
Cat.No: T39710
Synonym: Vepdegestrant
Target: Estrogen Receptor/ERR, PROTACs
GSK-4716
Cat.No: T5531
Synonym:
Target: Estrogen Receptor/ERR
Hexestrol
Cat.No: T6533
Synonym: Bibenzyl,4,4'-(1,2-二乙基亚乙基)二苯酚,Hexanoestrol,meso-Hexestrol,Hexestrofen
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Propyl pyrazole triol
Cat.No: T16566
Synonym: PPT
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
CMP8
Cat.No: T14987
Synonym:
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Diethylstilbestrol
Cat.No: T1216
Synonym: Stilbestrol,己烯雌酚,DES
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
G-1
Cat.No: T15364
Synonym:
Target: Estrogen Receptor/ERR, GPR
H3B-5942
Cat.No: T5633
Synonym:
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
XCT790
Cat.No: T0593
Synonym:
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Autophagy
WAY-200070
Cat.No: T3958
Synonym: WAY 200070
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Prochloraz
Cat.No: T20625
Synonym: 咪鲜胺,Sporgon,Prelude
Target: Estrogen Receptor/ERR, AhR, Androgen Receptor, Antifungal
Erteberel
Cat.No: T6306
Synonym: LY500307
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
GSK5182
Cat.No: T8370
Synonym:
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Reactive Oxygen Species
Elacestrant
Cat.No: T13674
Synonym: 依拉司群,RAD1901
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
(R)-Equol
Cat.No: T13443
Synonym: (+)-Equol,R-雌马酚
Target: Estrogen/progestogen Receptor
4,4'-Iminodiphenol
Cat.No: T13507
Synonym: 4-(4-羟基苯胺)苯酚,Leucoindophenol
Target: Estrogen/progestogen Receptor
Estradiol (cypionate)
Cat.No: T0168
Synonym: Depofemin,环戊丙酸雌二醇,Estradiol cypionate
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Dienestrol
Cat.No: T0035
Synonym: Restrol,双烯雌酚,Dehydrostilbestrol,Dienoestrol,Cycladiene
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Enclomiphene citrate
Cat.No: T7313
Synonym: 恩氯米芬柠檬酸盐,Enclomifene citrate,(E)-Clomiphene citrate,trans-Clomiphene citrate
Target: Estrogen Receptor/ERR
Gestrinone
Cat.No: T7223
Synonym: R 2323,孕三烯酮
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Bazedoxifene hydrochloride
Cat.No: T6404
Synonym: Bazedoxifene HCl,盐酸巴多昔芬,TSE-424
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
WAY-169916
Cat.No: T8981
Synonym: WAY 169916,WAY169916
Target: NF-κB
4-Hydroxytamoxifen
Cat.No: T4420
Synonym: ICI 79280,(Z)-4-hydroxy Tamoxifen,4-羟基他莫昔芬,trans-4-Hydroxytamoxifen
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Etonogestrel
Cat.No: T2567
Synonym: 3-Oxodesogestrel,3-keto-Desogestrel,依托孕烯,Nexplanon,Implanon
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Progesterone Receptor, Endogenous Metabolite
Estradiol benzoate
Cat.No: T0384
Synonym: Benzoestrofol,Benzhormovarine,苯甲酸雌二醇,Benovocylin
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Cat. No. Product Name Target Signaling Pathways
TN1052 Lindleyin

Estrogen Receptor/ERR; Estrogen/progestogen Receptor Endocrinology/Hormones
Lindleyin 是从 Rhei rhizoma 中分离得到，通过雌激素受体介导激素作用。它能够与 ERα结合，有类似雌激素的作用。
T5S0543 Isocurcumenol

Apoptosis; Estrogen Receptor/ERR; Reductase Apoptosis; Endocrinology/Hormones; Metabolism
Isocurcumenol 是从莪术中分离得到的一种天然产物，是一种ERα抑制剂，对 DLA 和 KB 癌细胞的IC50分别为 99.1 µg/mL 和 178.2 µg/mL，具有抗肿瘤活性。
T13768 (+)-Medicarpin

Estrogen/progestogen Receptor Endocrinology/Hormones
(+)-Medicarpin, a pterocarpan, is an isoflavonoid compound derived from multiple medicinal plant species such as Sophora japonica, Zollernia paraensis, Platymiscium yucatamun, Machaerium aristulatum, and Platymiscium floribundum. It exhibits potent inhibition of osteoclastogenesis and facilitates bone healing and increased bone mass through osteoblast differentiation, which is mediated by the estrogen receptor (ER) β.
T0301 Ethisterone

炔孕酮,17α-Ethynyltestosterone,Pregneninolone

 Estrogen Receptor/ERR; Estrogen/progestogen Receptor Endocrinology/Hormones
Ethisterone (17α-Ethynyltestosterone) 是一种口服活性类固醇避孕药，是一种合成类固醇雌激素。据报道，它具有雄激素活性，用于妇科疾病的研究。
T3665 Tectoridin

射干苷,Shekanin

 Estrogen Receptor/ERR; Reductase Endocrinology/Hormones; Metabolism
Tectoridin (Shekanin) 是分离自 Maackia amurensis 中的异黄酮，是一种植物雌激素，能够激活雌激素和甲状腺激素受体。它通过 ER 依赖性基因组途径和 GPR30 依赖性非基因组途径发挥雌激素作用。
T3855 Tracheloside

Estrogen Receptor/ERR; Phosphorylase Endocrinology/Hormones; Metabolism
Tracheloside 是抗雌激素木质素，利用 ERK1/2 刺激促进角质形成细胞增殖，是一种良好的促进伤口愈合的药物。
T13542 α-Zearalenol

Estrogen Receptor/ERR Endocrinology/Hormones
α-Zearalenol 是一种霉菌毒素，对雌激素受体具有高亲和力。它是 zearalenone (ZEN) 的一种衍生物，由于其异种雌激素效应可引起动物的生殖障碍。
T3913 Saikosaponin D

Estrogen Receptor/ERR; NF-κB; Antibacterial; STAT Endocrinology/Hormones; JAK/STAT signaling; Microbiology/Virology; NF-κB; Stem Cells
Saikosaponin D 是一种从柴胡中分离到的三萜皂苷类天然产物，具有抗炎，抗菌，抗肿瘤，抗过敏作用。它抑制 selectin，STAT3和 NF-kB 的活性，活化estrogen receptor-β。
T3325 Liquiritigenin

4',7-Dihydroxyflavanone,甘草素

 Estrogen Receptor/ERR; Estrogen/progestogen Receptor Endocrinology/Hormones
Liquiritigenin (4',7-Dihydroxyflavanone) 是一种黄烷酮，从甘草中分离得到，是高度选择性的雌激素受体β 激动剂，用于活化 ERE tk-Luc 的 EC50值为36.5 nM。
TQ0295 Coumestrol

拟雌内酯,考迈斯托醇

 Estrogen Receptor/ERR Endocrinology/Hormones
Coumestrol 是一种大豆产品中存在的植物雌激素。它抑制ES2细胞增殖的IC50值为50 μM。它可用于癌症，神经障碍和自身免疫疾病的研究。
T4000 (±)-Equol

Equol,(±)-雌马酚,(R,S)-Equol

 Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Drug Metabolite Endocrinology/Hormones; Metabolism
(±)-Equol ((R,S)-Equol) 是 equol 的外消旋体。它对 ERα 和 ERβ 的 EC50s of 分别为 200 和 74 nM。Equol 是大豆异黄酮黄豆苷和大豆黄素的代谢产物。
T3846 Bavachin

Corylifolin,补骨脂甲素,补骨脂二氢黄酮

 Estrogen Receptor/ERR; Estrogen/progestogen Receptor Endocrinology/Hormones
Bavachin (Corylifolin) 是一种从补骨脂种子中分离到的黄酮类物质，能够激活雌性激素受体 ERα (EC50:320 nM) 和 ERβ (EC50:680 nM)。
TMA1644 Segetalin B

王不留行环肽B,王不留行环肽 B

 Estrogen Receptor/ERR Endocrinology/Hormones
Segetalin B 是一种环五肽，可从Vaccaria segetalis 分离得到，具有类雌激素活性。
T1009 Estrone

Oestrone,雌酮,Fluoroethyl,Aquacrine

 Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite Endocrinology/Hormones; Metabolism
Estrone (Aquacrine) 是内源性雌激素的主要代表，由多种组织产生，尤其是脂肪组织。它是脂肪细胞中雄烯二酮芳构化过程的结果。
T1571 Estriol

NSC-12169,Oestriol,雌三醇

 Estrogen Receptor/ERR; Estrogen/progestogen Receptor; MRP; Endogenous Metabolite Endocrinology/Hormones; Immunology/Inflammation; Metabolism
Estriol (Oestriol) 是G 蛋白偶联雌激素受体拮抗剂，能够作用于雌激素受体阴性乳腺癌细胞。
T3840 Dihydroresveratrol

3,4',5-Trihydroxybibenzyl,二氢白藜芦醇,二氢藜芦醇

 Estrogen Receptor/ERR; Others Endocrinology/Hormones; Others
Dihydroresveratrol (3,4',5-Trihydroxybibenzyl) 是一种激素受体调节剂，是一种植物雌激素。它在皮摩尔和纳摩尔浓度下促进前列腺和乳腺癌细胞增殖。
T1048 Estradiol

雌二醇,E2,17β-Estradiol,17β-Oestradiol,β-Estradiol

 Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite Endocrinology/Hormones; Metabolism
Estradiol (E2) 是一种天然的类固醇性激素，对于女性生育能力和第二性征的维持至关重要。Estradiol 通过雌激素受体 β (ERβ) 上调 IL-6 表达。
T1590 Letrozole

CGS 20267,来曲唑

 Aromatase; Autophagy Autophagy; Endocrinology/Hormones
Letrozole (CGS 20267) 是一种可口服的，选择性可逆的非甾体类芳香化酶抑制剂，IC50值为 11.5 nM。它选择性抑制雌激素的生物合成，可研究乳腺癌。
T2837 Chrysin

5, 7-Dihydroxyflavone,NSC 407436,白杨素,5,7-Dihydroxyflavone

 Estrogen Receptor/ERR; Antioxidant Endocrinology/Hormones; oxidation-reduction
Chrysin (5,7-Dihydroxyflavone) 是一种雌激素阻断剂。
T3385 Gypenoside XVII

GP-17,Gynosaponin S,七叶胆苷XVII

 Estrogen Receptor/ERR; GSK-3; Endogenous Metabolite Endocrinology/Hormones; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells
Gypenoside XVII (Gynosaponin S) 是一种绞股蓝皂甙类的新型植物雌激素，能够激活雌激素受体。
T2177 Kaempferol

Kempferol,山柰酚,山奈酚,Robigenin

 Apoptosis; Estrogen Receptor/ERR; Mitophagy; Estrogen/progestogen Receptor; HIV Protease; Endogenous Metabolite; Parasite; Autophagy Apoptosis; Autophagy; Endocrinology/Hormones; Metabolism; Microbiology/Virology; Proteases/Proteasome
Kaempferol (Robigenin) 属于天然类黄酮，是一种 ERRα 和 ERRγ 的反向激动剂。Kaempferol 具有抗肿瘤、抗炎、抗氧化、抗菌和抗病毒等多种活性。
T36857 Estrone sulfate sodium

雌酮3-硫酸钠,Estrone 3-sulfate (sodium salt),17β-Estrone 3-sulfate

 Endogenous Metabolite Metabolism
Estrone sulfate sodium (17β-Estrone 3-sulfate) 是一种主要的循环血浆雌激素，无生物活性，通过类固醇硫酸酯酶(STS) 转化为生物活性雌激素雌酮。
T6491 (-)-(S)-Equol

(−)-Equol,Equol,4',7-Dihydroxyisoflavan,4',7-Isoflavandiol,雌马酚

 Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite Endocrinology/Hormones; Metabolism
(-)-(S)-Equol (4',7-Dihydroxyisoflavan) 是雌激素受体β的高亲和力配体。
T0760 Cholesterol

Cholesterin,Cholesteryl alcohol,胆固醇

 Estrogen Receptor/ERR; MRP; Endogenous Metabolite; ROR Endocrinology/Hormones; Immunology/Inflammation; Metabolism
Cholesterol (Cholesteryl alcohol) 属于天然产物，是哺乳动物中的主要固醇，是一种雌激素相关受体 α (ERRα) 的激动剂。Cholesterol 广泛存在于动物的细胞膜，也是合成几种重要荷尔蒙及胆酸的材料。
T1424 Ethynyl estradiol

乙炔基雌二醇,17α-Ethynylestradiol,Ethinyl Estradiol,炔雌醇

 Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite Endocrinology/Hormones; Metabolism
Ethynyl estradio 是一种高效的生物活性雌激素。
T2810 (20S)-Protopanaxatriol

原人参三醇,20(S)-APPT,20 (S)-原人参三醇,g-PPT

 Apoptosis; Estrogen Receptor/ERR; Glucocorticoid Receptor; Estrogen/progestogen Receptor; Liver X Receptor Apoptosis; Endocrinology/Hormones; Metabolism
(20S)-Protopanaxatriol (g-PPT) 是人参皂苷的代谢物，通过糖皮质激素受体和雌激素受体起作用，同时为LXRα的抑制剂，具有广泛的抗癌活性。
T0345 Estropipate

雌酮硫酸酯哌嗪,Piperazine estrone sulfate,Pipestrone,Estrone sulfate piperazine salt

 Estrogen Receptor/ERR; Estrogen/progestogen Receptor Endocrinology/Hormones
Estropipate (Piperazine estrone sulfate) 是一种由硫酸雌酮和哌嗪组成的天然雌激素物质。
TQ0274 27-Hydroxycholesterol

27-羟基胆固醇,5,25R-胆甾烯-3BETA,26-二醇,25(R)-27-hydroxy Cholesterol

 Estrogen/progestogen Receptor; Liver X Receptor Endocrinology/Hormones; Metabolism
27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) 是一种有效的、选择性的雌激素受体调节剂和肝X 受体激动剂。
T3806 kaempferide

Kaempferol 4'-O-methyl ether,山奈素,Kaempferol 4'-methyl ether,4'-Methylkaempferol,4'-O-Methylkaempferol

 Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Influenza Virus; Antibacterial; Autophagy Autophagy; Endocrinology/Hormones; Microbiology/Virology
kaempferide (4'-Methylkaempferol) 是一种存在于山柰中的O-甲基化黄酮醇，具有抗病毒活性。
T1549 Raloxifene hydrochloride

LY156758 hydrochloride,盐酸雷洛昔芬,Raloxifene HCl,LY139481 hydrochloride,Keoxifene hydrochloride,LY156758 (Keoxifene) HCl

 Estrogen Receptor/ERR; Others; MAO; Estrogen/progestogen Receptor; Autophagy Autophagy; Endocrinology/Hormones; Metabolism; Neuroscience; Others
Raloxifene hydrochloride (LY156758 hydrochloride) 是一种选择性且可口服的雌激素受体调节剂，用于预防绝经后妇女的骨质疏松症。它对骨骼和胆固醇代谢具有雌激素激动作用，但对乳腺和子宫组织具有完全的雌激素拮抗作用。
T2882 Genistin

染料木甙,Genistoside,Genistein glucoside,Genistein 7-glucoside,Genistine,Genistein 7-O-β-D-glucopyranoside,染料木苷

 Apoptosis; Estrogen Receptor/ERR; Others Apoptosis; Endocrinology/Hormones; Others
Genistin (Genistoside) 是一种植物雌激素家族的异黄酮，是一种抗脂肪生成剂。它通过调节ERalpha 信号通路抑制乳腺癌细胞生长和促进凋亡细胞死亡。
T7299 β-Estradiol 17-acetate

β-雌二醇 17-乙酸酯,17-乙酸-17-BETA-雌二酯,beta-estradiol 17-acetate,1,3,5(10)-Estratriene-3,17β-diol 17-acetate

 Estrogen Receptor/ERR; Others Endocrinology/Hormones; Others
β-Estradiol 17-acetate (1,3,5(10)-Estratriene-3,17β-diol 17-acetate) 是一种雌二醇代谢物。
TN1719 Gymnestrogenin

匙羹藤苷元,(3BETA,4ALPHA,16BETA,21BETA)-齐墩果-12-烯-3,16,21,23,28-五醇

 Liver X Receptor Metabolism
Gymnestrogenin has a dual LXRα±/α2 antagonistic profile.
T13481 2-Methoxyestrone

Endogenous Metabolite Metabolism
2-Methoxyestrone 是甲氧基苯二酚雌激素，也是雌酮代谢物，其 pKa=10.81。
T36857L Premarin

共轭雌激素,Estrone 3-sulfate,Estrone sulfate

 Estrogen Receptor/ERR Endocrinology/Hormones
Premarin (Estrone 3-sulfate) 是一种硫酸雌激素，在创伤性脑损伤期间具有神经保护作用。
TN2197 Secoisolariciresinol

TNF Apoptosis
Secoisolariciresinol 是一种属于苯丙素类的木脂素。
T15248 Estetrol

Donesta

 Estrogen Receptor/ERR; Endogenous Metabolite Endocrinology/Hormones; Metabolism
Estetrol(Donesta) 是可口服且具有选择性核雌激素受体 (estrogen receptor) 调节剂,是一种在怀孕期间由人类胎儿肝脏合成的天然雌激素。Estetrol 对子宫内膜或中枢神经系统有作用，但对乳房有拮抗作用。Estetrol 在低浓度时可能有助于降低血栓形成。Estetrol 可用于缓解更年期症状。
T3378 Alpha-Estradiol

α-雌二醇,Alfatradiol,雌二醇,17α-Estradiol,Epiestrol,Epiestradiol

 Estrogen/progestogen Receptor; Reductase; Endogenous Metabolite Endocrinology/Hormones; Metabolism
Alpha-Estradiol (Epiestradiol) 是一种雌性激素，可抑制5α-reductase，在雄原性脱发的研究中有潜力。
T73772 Estrone sulfate potassium

Endogenous Metabolite Metabolism
Estrone sulfate potassium 是一种雌激素酯和共轭物，是一种天然内源性类固醇。
TN1148 Isopsoralenoside

Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Antibacterial Endocrinology/Hormones; Microbiology/Virology
Isopsoralenoside 是补骨脂多糖中的一种苯并呋喃苷。它在消化道内容物中可迅速代谢为补骨脂素。它具有雌激素样活性、促进成骨细胞增殖活性、抗肿瘤活性和抗菌活性。
TN1008 Psoralenoside

CaMK; Calcium Channel; Histamine Receptor GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience
Psoralenoside 是源于补骨脂中的苯并呋喃苷，具有抗肿瘤、抗菌、促进成骨细胞增殖和雌激素样活性。它对组胺 H1、钙调素和电压门控 l 型钙通道具有较高的亲和力。
T16525 PhIP

Others Others
PhIP 是来源于熟肉的一种杂环芳香胺(HAA)，属于吡啶类杂环胺，是2B 类致癌物，具有雌激素活性。PhIP 可与 DNA 形成加合物，从而促进癌症发生。
TN1702 Glycycoumarin

甘草香豆素

 P450; JNK; AMPK; Autophagy Autophagy; Chromatin/Epigenetic; MAPK; Metabolism; PI3K/Akt/mTOR signaling
Glycycoumarin 是甘草中的一种香豆素，能直接靶向 T-LAK 细胞源蛋白激酶发挥抗肝癌活性 。它通过激活自噬，抑制内质网应激介导的 JNK 和 GSK-3 介导的线粒体途径，来抑制肝细胞脂性凋亡。它是一种雌激素激动剂，对 CYP1A2 和 CYP2B6 有中度抑制作用。
T2777 Ginsenoside Rg1

Sanchinoside C1,Panaxoside Rg1,Sanchinoside Rg1,人参皂苷Rg1,Panaxoside A,人参皂苷 Rg1,Ginsenoside A2

 Apoptosis; Beta Amyloid; NF-κB Apoptosis; Neuroscience; NF-κB
Ginsenoside Rg1 (Panaxoside Rg1) 是人参的主要活性成分之一，可减少NF-κB 核易位。它改善认知功能受损，通过降低大脑Aβ水平来发挥作用。
T16338 Norgestimate metabolite Norelgestromin

17-Deacetyl norgestimate,17-Deacylnorgestimate,甲基孕酮

 Drug Metabolite Metabolism
Norgestimate metabolite Norelgestromin (17-Deacylnorgestimate) 是norgestimate 的一种活性代谢物。它是用于避孕贴片的甾体孕激素，与雌激素乙炔雌二醇结合使用。
T3717 Hinokitiol

4-Isopropyltropolone,桧木醇,β-thujaplicin,β-桧木醇

 DNA Methyltransferase; Virus Protease; Estrogen/progestogen Receptor; Nrf2 Chromatin/Epigenetic; Endocrinology/Hormones; Immunology/Inflammation; Microbiology/Virology
Hinokitiol (4-Isopropyltropolone) 是从日本扁柏中分离到的一种挥发油成分，可抑制紫外线 B 诱导的角质形成细胞凋亡，可调节雌激素受体信号传导并抑制人乳腺癌细胞的增殖。它具有抗感染、抗氧化及抗肿瘤等活性。
T64744 Ovalbumins

Endogenous Metabolite Metabolism
Ovalbumins 是蛋清中的主要蛋白质。Ovalbumins 具有多种生物活性，如降压、抗菌、抗癌、抗氧化和免疫调节活性。Ovalbumins 是雌激素或孕酮处理的输卵管中合成的丰富的蛋白质。Ovalbumins 通常用作研究激素控制该组织中基因表达的标志物。
T3923 Calycosin

Cyclosin,3'-Hydroxyformononetin,异黄酮,毛异黄酮

 Apoptosis; Tyrosinase Apoptosis; Proteases/Proteasome
Calycosin (Cyclosin) 是一抗氧化和抗炎症活性天然产物。
T1660 Silibinin

水飞蓟宾 A,水飞蓟宾,Silibinin A,Silybin,Silymarin I

 Reactive Oxygen Species; Autophagy Autophagy; Immunology/Inflammation; Metabolism; NF-κB
Silibinin (Silybin) 是水飞蓟的主要活性成分，具有抗癌和化疗预防作用，能抑制细胞增殖和迁移。
T3390 Obacunone

Apoptosis; Aromatase; p38 MAPK Apoptosis; Endocrinology/Hormones; MAPK
Obacunone 是从沼泽白葡萄柚种子中分离得到的，通过诱导凋亡发挥抗癌作用。它在雄激素依赖性人前列腺 Y 细胞中具有细胞毒性。它对鼠伤寒沙门氏菌具有抗毒作用，可作为开发鼠伤寒沙门氏菌抗毒策略的先导化合物。
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天然产物

Lindleyin
Cat.No: TN1052
Synonym:
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Isocurcumenol
Cat.No: T5S0543
Synonym:
Target: Apoptosis, Estrogen Receptor/ERR, Reductase
(+)-Medicarpin
Cat.No: T13768
Synonym:
Target: Estrogen/progestogen Receptor
Ethisterone
Cat.No: T0301
Synonym: 炔孕酮,17α-Ethynyltestosterone,Pregneninolone
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Tectoridin
Cat.No: T3665
Synonym: 射干苷,Shekanin
Target: Estrogen Receptor/ERR, Reductase
Tracheloside
Cat.No: T3855
Synonym:
Target: Estrogen Receptor/ERR, Phosphorylase
α-Zearalenol
Cat.No: T13542
Synonym:
Target: Estrogen Receptor/ERR
Saikosaponin D
Cat.No: T3913
Synonym:
Target: Estrogen Receptor/ERR, NF-κB, Antibacterial, STAT
Liquiritigenin
Cat.No: T3325
Synonym: 4',7-Dihydroxyflavanone,甘草素
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Coumestrol
Cat.No: TQ0295
Synonym: 拟雌内酯,考迈斯托醇
Target: Estrogen Receptor/ERR
(±)-Equol
Cat.No: T4000
Synonym: Equol,(±)-雌马酚,(R,S)-Equol
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Drug Metabolite
Bavachin
Cat.No: T3846
Synonym: Corylifolin,补骨脂甲素,补骨脂二氢黄酮
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Segetalin B
Cat.No: TMA1644
Synonym: 王不留行环肽B,王不留行环肽 B
Target: Estrogen Receptor/ERR
Estrone
Cat.No: T1009
Synonym: Oestrone,雌酮,Fluoroethyl,Aquacrine
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Endogenous Metabolite
Estriol
Cat.No: T1571
Synonym: NSC-12169,Oestriol,雌三醇
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, MRP, Endogenous Metabolite
Dihydroresveratrol
Cat.No: T3840
Synonym: 3,4',5-Trihydroxybibenzyl,二氢白藜芦醇,二氢藜芦醇
Target: Estrogen Receptor/ERR, Others
Estradiol
Cat.No: T1048
Synonym: 雌二醇,E2,17β-Estradiol,17β-Oestradiol,β-Estradiol
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Endogenous Metabolite
Letrozole
Cat.No: T1590
Synonym: CGS 20267,来曲唑
Target: Aromatase, Autophagy
Chrysin
Cat.No: T2837
Synonym: 5, 7-Dihydroxyflavone,NSC 407436,白杨素,5,7-Dihydroxyflavone
Target: Estrogen Receptor/ERR, Antioxidant
Gypenoside XVII
Cat.No: T3385
Synonym: GP-17,Gynosaponin S,七叶胆苷XVII
Target: Estrogen Receptor/ERR, GSK-3, Endogenous Metabolite
Kaempferol
Cat.No: T2177
Synonym: Kempferol,山柰酚,山奈酚,Robigenin
Target: Apoptosis, Estrogen Receptor/ERR, Mitophagy, Estrogen/progestogen Receptor, HIV Protease, Endogenous Metabolite, Parasite, Autophagy
Estrone sulfate sodium
Cat.No: T36857
Synonym: 雌酮3-硫酸钠,Estrone 3-sulfate (sodium salt),17β-Estrone 3-sulfate
Target: Endogenous Metabolite
(-)-(S)-Equol
Cat.No: T6491
Synonym: (−)-Equol,Equol,4',7-Dihydroxyisoflavan,4',7-Isoflavandiol,雌马酚
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Endogenous Metabolite
Cholesterol
Cat.No: T0760
Synonym: Cholesterin,Cholesteryl alcohol,胆固醇
Target: Estrogen Receptor/ERR, MRP, Endogenous Metabolite, ROR
Ethynyl estradiol
Cat.No: T1424
Synonym: 乙炔基雌二醇,17α-Ethynylestradiol,Ethinyl Estradiol,炔雌醇
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Endogenous Metabolite
(20S)-Protopanaxatriol
Cat.No: T2810
Synonym: 原人参三醇,20(S)-APPT,20 (S)-原人参三醇,g-PPT
Target: Apoptosis, Estrogen Receptor/ERR, Glucocorticoid Receptor, Estrogen/progestogen Receptor, Liver X Receptor
Estropipate
Cat.No: T0345
Synonym: 雌酮硫酸酯哌嗪,Piperazine estrone sulfate,Pipestrone,Estrone sulfate piperazine salt
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
27-Hydroxycholesterol
Cat.No: TQ0274
Synonym: 27-羟基胆固醇,5,25R-胆甾烯-3BETA,26-二醇,25(R)-27-hydroxy Cholesterol
Target: Estrogen/progestogen Receptor, Liver X Receptor
kaempferide
Cat.No: T3806
Synonym: Kaempferol 4'-O-methyl ether,山奈素,Kaempferol 4'-methyl ether,4'-Methylkaempferol,4'-O-Methylkaempferol
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Influenza Virus, Antibacterial, Autophagy
Raloxifene hydrochloride
Cat.No: T1549
Synonym: LY156758 hydrochloride,盐酸雷洛昔芬,Raloxifene HCl,LY139481 hydrochloride,Keoxifene hydrochloride,LY156758 (Keoxifene) HCl
Target: Estrogen Receptor/ERR, Others, MAO, Estrogen/progestogen Receptor, Autophagy
Genistin
Cat.No: T2882
Synonym: 染料木甙,Genistoside,Genistein glucoside,Genistein 7-glucoside,Genistine,Genistein 7-O-β-D-glucopyranoside,染料木苷
Target: Apoptosis, Estrogen Receptor/ERR, Others
β-Estradiol 17-acetate
Cat.No: T7299
Synonym: β-雌二醇 17-乙酸酯,17-乙酸-17-BETA-雌二酯,beta-estradiol 17-acetate,1,3,5(10)-Estratriene-3,17β-diol 17-acetate
Target: Estrogen Receptor/ERR, Others
Gymnestrogenin
Cat.No: TN1719
Synonym: 匙羹藤苷元,(3BETA,4ALPHA,16BETA,21BETA)-齐墩果-12-烯-3,16,21,23,28-五醇
Target: Liver X Receptor
2-Methoxyestrone
Cat.No: T13481
Synonym:
Target: Endogenous Metabolite
Premarin
Cat.No: T36857L
Synonym: 共轭雌激素,Estrone 3-sulfate,Estrone sulfate
Target: Estrogen Receptor/ERR
Secoisolariciresinol
Cat.No: TN2197
Synonym:
Target: TNF
Estetrol
Cat.No: T15248
Synonym: Donesta
Target: Estrogen Receptor/ERR, Endogenous Metabolite
Alpha-Estradiol
Cat.No: T3378
Synonym: α-雌二醇,Alfatradiol,雌二醇,17α-Estradiol,Epiestrol,Epiestradiol
Target: Estrogen/progestogen Receptor, Reductase, Endogenous Metabolite
Estrone sulfate potassium
Cat.No: T73772
Synonym:
Target: Endogenous Metabolite
Isopsoralenoside
Cat.No: TN1148
Synonym:
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Antibacterial
Psoralenoside
Cat.No: TN1008
Synonym:
Target: CaMK, Calcium Channel, Histamine Receptor
PhIP
Cat.No: T16525
Synonym:
Target: Others
Glycycoumarin
Cat.No: TN1702
Synonym: 甘草香豆素
Target: P450, JNK, AMPK, Autophagy
Ginsenoside Rg1
Cat.No: T2777
Synonym: Sanchinoside C1,Panaxoside Rg1,Sanchinoside Rg1,人参皂苷Rg1,Panaxoside A,人参皂苷 Rg1,Ginsenoside A2
Target: Apoptosis, Beta Amyloid, NF-κB
Norgestimate metabolite Norelgestromin
Cat.No: T16338
Synonym: 17-Deacetyl norgestimate,17-Deacylnorgestimate,甲基孕酮
Target: Drug Metabolite
Hinokitiol
Cat.No: T3717
Synonym: 4-Isopropyltropolone,桧木醇,β-thujaplicin,β-桧木醇
Target: DNA Methyltransferase, Virus Protease, Estrogen/progestogen Receptor, Nrf2
Ovalbumins
Cat.No: T64744
Synonym:
Target: Endogenous Metabolite
Calycosin
Cat.No: T3923
Synonym: Cyclosin,3'-Hydroxyformononetin,异黄酮,毛异黄酮
Target: Apoptosis, Tyrosinase
Silibinin
Cat.No: T1660
Synonym: 水飞蓟宾 A,水飞蓟宾,Silibinin A,Silybin,Silymarin I
Target: Reactive Oxygen Species, Autophagy
Obacunone
Cat.No: T3390
Synonym:
Target: Apoptosis, Aromatase, p38 MAPK
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Species：
Human (20)
Mouse (2)
Canine (1)
Cynomolgus (1)
Expression System：
E. coli (11)
HEK293 Cells (9)
Baculovirus Insect Cells (3)
P. pastoris (Yeast) (1)
Tag：
N-6xHis (5)
N-His (4)
C-6xHis (3)
C-His (3)
N-GST (2)
C-10xHis (1)
C-6xHis, N-T7 (1)
C-hFc (1)
C-mFc (1)
N-10xHis, C-Myc (1)
Cat. No. Product Name Species Expression System
TMPJ-00762 ER alpha Protein, Human, Recombinant (His)

Estrogen Receptor,ER α,estrogen receptor α...

 Human E. coli
Estrogen Receptor is a major ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. Estrogen Receptor is composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but they also play a role in other tissues such as ...
TMPH-02142 ERR1 Protein, Human, Recombinant (GST)

Steroid hormone receptor ERR1,Estrogen receptor-lik...

 Human E. coli
Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.
TMPY-03496 EBAG9 Protein, Human, Recombinant (His)

EB9,PDAF,estrogen receptor binding site associated,...

 Human E. coli
RCAS1, also known as EBAG9, is a tumor-associated antigen that is expressed at high frequency in a variety of cancers. RCAS1 gene was identified as an estrogen-responsive gene. Regulation of transcription by estrogen is mediated by estrogen receptor which binds to the estrogen-responsive element (ERE) found in the 5'-flanking region of RCAS1 gene. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for RCAS1 gene. EBAG9 may participate in s...
TMPH-01305 ER beta Protein, Human, Recombinant (His)

Nuclear receptor subfamily 3 group A member 2,Estrogen

Human P. pastoris (Yeast)
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.; Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. ER beta Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 61.1 kDa and the accessio...
TMPH-01304 ER beta Protein, Human, Recombinant (E. coli, His)

ESR2,Nuclear receptor subfamily 3 group A member 2,Estro...

 Human E. coli
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.; Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. ER beta Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight...
TMPH-00956 Aromatase/CYP19A1 Protein, Human, Recombinant (His)

ARO1,CYP19A1,Estrogen synthase,Cytochrome P450 19A1...

 Human E. coli
Aromatase/CYP19A1 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-02324 SLC39A6 Protein, Human, Recombinant (His)

Solute carrier family 39 member 6,Zinc transporter ZIP6,...

 Human Baculovirus Insect Cells
May act as a zinc-influx transporter. SLC39A6 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with C-6xHis tag. The predicted molecular weight is 35.0 kDa and the accession number is Q13433.
TMPY-04396 C-ABL/ABL1 Protein, Human, Recombinant (GST)

v-abl,ABL,JTK7,ABL proto-oncogene 1, non-receptor tyrosine k...

 Human Baculovirus Insect Cells
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity an...
TMPJ-01192 ELAPOR1 Protein, Human, Recombinant (His)

ELAPOR1,Endosome-Lysosome Associated Apoptosis And Autophagy...

 Human HEK293 Cells
Endosome/lysosome-associated apoptosis and autophagy regulator (ELAPOR1), also known as EIG121 protein, is a type I transmembrane protein induced by estrogen. The estrogen-induced gene 121 (EIG121) has been associated with breast and endometrial cancers,but its mechanism of action remains unknown.May protect cells from cell death by inducing cytosolic vacuolization and upregulating the autophagy pathway. That EIG121 is a good endometrial biomarker associated with a hyperestrogenic state and estr...
TMPY-01660 SULT1E1 Protein, Human, Recombinant (His)

ST1E1,EST,sulfotransferase family 1E member 1,EST-1,STE,MGC3...

 Human E. coli
Estrogen sulfotransferase, also known as Sulfotransferase, estrogen-preferring, Sulfotransferase 1E1, SULT1E1 and ST1E1, is a cytoplasm enzyme that belongs to the sulfotransferase 1 family. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. SULT1E1 may control the level of the estrogen receptor by sulfurylating free estradio...
TMPH-00498 Prorelaxin Protein, Canine, Recombinant (His)

RLN,Prorelaxin

 Canine E. coli
Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. Prorelaxin Protein, Canine, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.6 kDa and the accession number is Q9TRM8.
TMPH-02851 PDIA2 Protein, Mouse, Recombinant (His & SUMO)

PDIp,Pdia2,Protein disulfide-isomerase A2

 Mouse E. coli
Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins.
TMPH-01302 HSD17B1 Protein, Human, Recombinant (His & Myc)

Placental 17-beta-hydroxysteroid dehydrogenase,Short chain d...

 Human E. coli
Favors the reduction of estrogens and androgens. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2). Also has 20-alpha-HSD activity. Uses preferentially NADH. HSD17B1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 42.3 kDa and the accession number is P14061.
TMPY-00375 VMO1 Protein, Human, Recombinant (mFc)

ERGA6350,PRO21055,vitelline membrane outer layer 1 homolog (...

 Human HEK293 Cells
Vitelline membrane outer layer protein 1 (VMO1), a basic protein present in the outer layer of the vitelline membrane of eggs, plays essential roles in separating the yolk from the egg white and preventing infection from bacteria by forming a barrier of fibrous layers in avian eggs. VMO1 is regulated by estrogen and target microRNAs and it is a potential diagnostic marker of ovarian cancer in laying hens. VMO1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag....
TMPJ-00705 BCAS2 Protein, Human, Recombinant (His, T7)

BCAS2,DNA Amplified in Mammary Carcinoma 1 Protein,Pre-mRNA-...

 Human E. coli
Breast Carcinoma-Amplified Sequence 2 (BCAS2) is a member of the SPF27 family. BCAS2 is a nuclear protein and widely expressed in many rtissues. BCAS2 is identified as being overexpressed in various breast cancer cell lines. BCAS2 is a component of the spliceosome, taking part in the removal of introns from mRNA precursors. BCAS2 interacts with estrogen receptor alpha and beta, thyroid hormone receptor beta, peroxisome proliferator-activated receptor gamma. BCAS2 functions as an ER co-activator ...
TMPY-04780 VMO1 Protein, Human, Recombinant

vitelline membrane outer layer 1 homolog (chicken),PRO21055,...

 Human HEK293 Cells
Vitelline membrane outer layer protein 1 (VMO1), a basic protein present in the outer layer of the vitelline membrane of eggs, plays essential roles in separating the yolk from the egg white and preventing infection from bacteria by forming a barrier of fibrous layers in avian eggs. VMO1 is regulated by estrogen and target microRNAs and it is a potential diagnostic marker of ovarian cancer in laying hens. VMO1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted mole...
TMPY-01826 Relaxin 1/RLN1 Protein, Human, Recombinant (His)

RLXH1,H1RLX,relaxin 1,bA12D24.3.1,H1,RLN1,bA12D24.3.2

 Human HEK293 Cells
Relaxin-1, also known as Prorelaxin H1 and RLN1, is a secreted protein that belongs to the insulin family. It is a peptide hormone that was first described in 1926 by Frederick Hisaw. Since its discovery as a reproductive hormone 8 years ago, relaxin has been implicated in a number of pregnancy-related functions involving extracellular matrix (ECM) turnover and collagen degradation. It is now becoming evident that relaxin's ability to reduce matrix synthesis and increase ECM degradation has impo...
TMPJ-00056 AG-2 Protein, Human, Recombinant (His)

HPC8,AG2,AG-2,hAG-2,Anterior Gradient Protein 2 Homolog,AGR2...

 Human HEK293 Cells
Anterior Gradient 2 (AGR2) is an 18-21 kDa member of the PDI family of enzymes. AGR2 is widely expressed in secretory cells, such as small intestine goblet, prostate epithelium, enteroendocrine cells, and multiple carcinoma cell types. AGR2 forms transient disulfide linkages with molecules destined for secretion, possibly aiding protein folding. Expression of AGR2 shows a positive correlation with expression of estrogen receptor in breast carcinoma and a negative correlation with expression of E...
TMPY-06226 SLC39A6/LIV-1 Protein, Cynomolgus, Recombinant (His)

solute carrier family 39 member 6

 Cynomolgus HEK293 Cells
Along with the SLC30 family, SLC39 family members regulate zinc movement in cells. SLC39 metal ion transporters accumulate zinc into the cytosol. SLC39A6, also known as LIV-1, belongs to a new subfamily of Zrt, Irt-like protein zinc transporters (LZTs). It is involved in maintaining the intracellular homeostasis of zinc, an ion that is essential in the control of cellular growth and differentiation. SLC39A6 plays a critical role in maintaining zinc homeostasis, and was originally identified as a...
TMPJ-00253 OPG Protein, Mouse, Recombinant (His)

Opg,Ocif,Tnfrsf11b,Osteoclastogenesis inhibitory factor,Oste...

 Mouse HEK293 Cells
Osteoprotegerin (OPG, Tnfrsf11b) is a secreted protein that regulates bone density. OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells, fibroblasts and endothelial cells. Regulation of its expression by estrogen, parathyroid hormone and cytokines is complex and changes with age. OPG acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TRAIL decreases the release of OPG from cells that express it, while OPG ...
TMPY-04828 TFF3 Protein, Human, Recombinant (His)

trefoil factor 3 (intestinal),ITF,P1B,TFI

 Human HEK293 Cells
Trefoil factor family (TFF) peptides are involved in the maintenance of epithelial integrity and epithelial restitution. Trefoil factor-3 (TFF3) is an estrogen-regulated gene associated with prognosis in different types of cancer. The presence and localization of TFF3 peptide was associated with the embryonic stage and tissue differentiation. TFF3 peptide distribution specific to the germ layers was not observed. The role of TFF3 peptide in cell migration and differentiation, immune response, an...
TMPY-02843 GPX7 Protein, Human, Recombinant (hFc)

GSHPx-7,UNQ469/PRO828,NPGPx,CL683,glutathione peroxidase 7,G...

 Human HEK293 Cells
GPX7 gene contains 3 distinct gt-ag introns. Transcription produces 4 different mRNAs, 3 alternatively spliced variants, and 1 unspliced form. There are 5 validated alternative polyadenylation sites. The mRNAs appear to differ by overlapping exons with different boundaries. GPX7 is an enzyme. It has molecular functions (glutathione peroxidase activity, oxidoreductase activity) and to localize in various compartments (extracellular space, extracellular region). GPX7 gene has been proposed to part...
TMPY-04422 Casein Kinase 1 gamma 2 Protein, Human, Recombinant (His)

CK1g2,casein kinase 1, γ2,casein kinase 1, gamma 2,Casein Ki...

 Human Baculovirus Insect Cells
Casein kinase I gamma 2 isoform (CSNK1G2), a member of the large casein kinase I (CKI) subfamily, protein kinase superfamily. It may affect the development of brain, and associate with vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. The CKI family includes several other isoforms (alpha, beta, gamma, and delta). Dishevelled (Dsh), another positive component of the Wnt pathway, becomes phosphorylated in response to Wnt signals. All the CKI isoforms, with the exce...
TMPY-02214 OTUB1 Protein, Human, Recombinant (His)

OTU deubiquitinase, ubiquitin aldehyde binding 1,OTB1,HSPC26...

 Human E. coli
Ubiquitin thioesterase OTUB1, also known as Deubiquitinating enzyme OTUB1, OTU domain-containing ubiquitin aldehyde-binding protein 1, Otubain-1, Ubiquitin-specific-processing protease OTUB1, OTUB1 and OTB1, is a cytoplasm protein that belongs to the peptidase C65 family. OTUB1 is a hydrolase that can remove conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. OTUB1 is a regulator of T-cell anergy, a phenomenon that...

重组蛋白

ER alpha Protein, Human, Recombinant (His)
Cat.No: TMPJ-00762
Species: Human
Expression System: E. coli
ERR1 Protein, Human, Recombinant (GST)
Cat.No: TMPH-02142
Species: Human
Expression System: E. coli
EBAG9 Protein, Human, Recombinant (His)
Cat.No: TMPY-03496
Species: Human
Expression System: E. coli
ER beta Protein, Human, Recombinant (His)
Cat.No: TMPH-01305
Species: Human
Expression System: P. pastoris (Yeast)
ER beta Protein, Human, Recombinant (E. coli, His)
Cat.No: TMPH-01304
Species: Human
Expression System: E. coli
Aromatase/CYP19A1 Protein, Human, Recombinant (His)
Cat.No: TMPH-00956
Species: Human
Expression System: E. coli
SLC39A6 Protein, Human, Recombinant (His)
Cat.No: TMPH-02324
Species: Human
Expression System: Baculovirus Insect Cells
C-ABL/ABL1 Protein, Human, Recombinant (GST)
Cat.No: TMPY-04396
Species: Human
Expression System: Baculovirus Insect Cells
ELAPOR1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01192
Species: Human
Expression System: HEK293 Cells
SULT1E1 Protein, Human, Recombinant (His)
Cat.No: TMPY-01660
Species: Human
Expression System: E. coli
Prorelaxin Protein, Canine, Recombinant (His)
Cat.No: TMPH-00498
Species: Canine
Expression System: E. coli
PDIA2 Protein, Mouse, Recombinant (His & SUMO)
Cat.No: TMPH-02851
Species: Mouse
Expression System: E. coli
HSD17B1 Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01302
Species: Human
Expression System: E. coli
VMO1 Protein, Human, Recombinant (mFc)
Cat.No: TMPY-00375
Species: Human
Expression System: HEK293 Cells
BCAS2 Protein, Human, Recombinant (His, T7)
Cat.No: TMPJ-00705
Species: Human
Expression System: E. coli
VMO1 Protein, Human, Recombinant
Cat.No: TMPY-04780
Species: Human
Expression System: HEK293 Cells
Relaxin 1/RLN1 Protein, Human, Recombinant (His)
Cat.No: TMPY-01826
Species: Human
Expression System: HEK293 Cells
AG-2 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00056
Species: Human
Expression System: HEK293 Cells
SLC39A6/LIV-1 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPY-06226
Species: Cynomolgus
Expression System: HEK293 Cells
OPG Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-00253
Species: Mouse
Expression System: HEK293 Cells
TFF3 Protein, Human, Recombinant (His)
Cat.No: TMPY-04828
Species: Human
Expression System: HEK293 Cells
GPX7 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-02843
Species: Human
Expression System: HEK293 Cells
Casein Kinase 1 gamma 2 Protein, Human, Recombinant (His)
Cat.No: TMPY-04422
Species: Human
Expression System: Baculovirus Insect Cells
OTUB1 Protein, Human, Recombinant (His)
Cat.No: TMPY-02214
Species: Human
Expression System: E. coli
Cat. No. Product Name Target Signaling Pathways
T12329 Ospemifene D4

FC-1271a D4

 Estrogen/progestogen Receptor Endocrinology/Hormones
Ospemifene D4 is a deuterium labeled Ospemifene. Ospemifene is a selective and orally active modulator of estrogen receptor.
T13076 Tamoxifen-​d5

ICI 47699-​d5,(Z)-Tamoxifen-​d5,trans-Tamoxifen-​d5

 HSP Cytoskeletal Signaling; Metabolism
Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). Tamoxifen is a potent activator of Hsp90 and enhances the Hsp90 molecular chaperone ATPase activity.
TMID-0055 17β-estradiol-d4

17β-estradiol-d4 是 17β-estradiol 的氘代化合物。17β-estradiol 的 CAS 号为 50-28-2。Estradiol 是一种类固醇性激素，对于女性生育能力和第二性征的维持至关重要。它通过雌激素受体 β 途径上调 IL-6 表达。
TMIJ-0028 17β-Estradiol-2,4-d2

17β-Estradiol-2,4-d2 是 17β-Estradiol 的氘代化合物。17β-Estradiol 的 CAS 号为 50-28-2。Estradiol 是一种类固醇性激素，对于女性生育能力和第二性征的维持至关重要。它通过雌激素受体 β 途径上调 IL-6 表达。
TMIJ-0032 17beta-Estradiol-13C2

17beta-Estradiol-13C2 是 17beta-Estradiol 的 13C 的标记化合物。17beta-Estradiol 的 CAS 号为 50-28-2。Estradiol 是一种类固醇性激素，对于女性生育能力和第二性征的维持至关重要。它通过雌激素受体 β 途径上调 IL-6 表达。
TMID-0024 Dienestrol-d6

Dienestrol-d6 是 Dienestrol 的氘代化合物。Dienestrol 的 CAS 号为 84-17-3。Dienestrol 是一种雌激素受体激动剂，是一种合成的非甾体类雌激素，用于对绝经期和绝经后症状的相关研究。
TMID-0108 17β-Estradiol-2,4,16,16,17-d5

17β-Estradiol-2,4,16,16,17-d5 是 17β-Estradiol 的氘代化合物。17β-Estradiol 的 CAS 号为 50-28-2。Estradiol 是一种类固醇性激素，对于女性生育能力和第二性征的维持至关重要。它通过雌激素受体 β 途径上调 IL-6 表达。
TMIJ-0038 α-Zearalenol-d5

α-Zearalenol-d5 是 α-Zearalenol 的氘代化合物。α-Zearalenol 的 CAS 号为 36455-72-8。α-Zearalenol 是一种霉菌毒素，对雌激素受体具有高亲和力。α-Zearalenol 是 zearalenone (ZEN) 的一种衍生物，由于其异种雌激素效应可引起动物的生殖障碍。
TMIJ-0196 17β-Estradiol-16,16,17-d3

17β-Estradiol-16,16,17-d3 是 17β-Estradiol 的氘代化合物。17β-Estradiol 的 CAS 号为 50-28-2。Estradiol 是一种类固醇性激素，对于女性生育能力和第二性征的维持至关重要。它通过雌激素受体 β 途径上调 IL-6 表达。
TMID-0140 2-Methoxyestrone-1,4,16,16-d4

2-Methoxyestrone-1,4,16,16-d4 是 2-Methoxyestrone 的氘代化合物。2-Methoxyestrone 的 CAS 号为 362-08-3。2-Methoxyestrone 是甲氧基苯二酚雌激素，也是雌酮代谢物，其 pKa=10.81。
TMIJ-0040 17alpha-Estradiol-2,4-d2

17alpha-Estradiol-2,4-d2 是 17alpha-Estradiol 的氘代化合物。17alpha-Estradiol 的 CAS 号为 57-91-0。17α-Estradiol 是一种雌性激素，可抑制5α-reductase，在雄原性脱发的研究中有潜力。
TMIJ-0244 Fulvestrant-d3

Fulvestrant-d3 是 Fulvestrant 的氘代化合物。Fulvestrant 的 CAS 号为 129453-61-8。Fulvestrant是纯抗雌激素，也是一种雌激素受体拮抗剂，IC50为 9.4 nM。它抑制ER阳性 MCF-7 细胞的生长，IC50为 0.29 nM。它还是一种GPR30的激动剂。它可诱导细胞自噬和凋亡，有抗肿瘤作用。
TMIJ-0280 Estriol-d3

Estriol-d3 是 Estriol 的氘代化合物。Estriol 的 CAS 号为 50-27-1。Estriol 是G蛋白偶联雌激素受体拮抗剂，能够作用于雌激素受体阴性乳腺癌细胞。
TMIJ-0035 16α-Hydroxy-17β-estradiol-2,4-d2

16α-Hydroxy-17β-estradiol-2,4-d2 是 Estriol 的氘代化合物。Estriol 的 CAS 号为 50-27-1。Estriol 是G蛋白偶联雌激素受体拮抗剂，能够作用于雌激素受体阴性乳腺癌细胞。
TMIJ-0313 Estrone-d2

Estrone-d2 是 Estrone 的氘代化合物。Estrone 的 CAS 号为 53-16-7。Aquacrine是内源性雌激素的主要代表，由多种组织产生，尤其是脂肪组织。它是脂肪细胞中雄烯二酮芳构化过程的结果。
TMID-0091 BISPHENOL A-d16

BISPHENOL A-d16 是 BISPHENOL-A 的氘代化合物。BISPHENOL-A 的 CAS 号为 80-05-7。Bisphenol A 是酚类有机合成化合物，广泛用于环氧树脂和聚碳酸酯塑料的生产。它是生殖、发育和全身毒性物质，常被归类为内分泌干扰物。它与许多疾病有关，包括呼吸系统疾病、心血管疾病、糖尿病、肾脏疾病、肥胖和生殖障碍。
TMIJ-0255 Estrone-d4

Estriol EP Impurity B-d4
Estrone-d4 是 Estrone 的氘代化合物。Estrone 的 CAS 号为 53-16-7。Aquacrine是内源性雌激素的主要代表，由多种组织产生，尤其是脂肪组织。它是脂肪细胞中雄烯二酮芳构化过程的结果。
T35783 Zearalenone-13C18

Zearalenone-13C18
Zearalenone-13C18is intended for use as an internal standard for the quantification of zearalenone by GC- or LC-MS. Zearalenone is a mycotoxin that has been found inFusariumand has estrogenic activities.1It binds to human estrogen receptor α (ERα) and ERβ (IC50s = 9 and 5.8 nM, respectively).2Zearalenone induces precocious development of mammary tissues in young female pigs and prepucial enlargement in young male pigs.3Zearalenone (1.5-5 mg/kg of diet) induces hyperestrogenism in pigs. It also i...
TMID-0090 BISPHENOL-A-2,2',3,3',5,5',6,6'-d8

BISPHENOL-A-2,2',3,3',5,5',6,6'-d8 是 BISPHENOL-A 的氘代化合物。BISPHENOL-A 的 CAS 号为 80-05-7。Bisphenol A 是酚类有机合成化合物，广泛用于环氧树脂和聚碳酸酯塑料的生产。它是生殖、发育和全身毒性物质，常被归类为内分泌干扰物。它与许多疾病有关，包括呼吸系统疾病、心血管疾病、糖尿病、肾脏疾病、肥胖和生殖障碍。
TMID-0093 BISPHENOL-A-2,2',6,6'-d4

BISPHENOL-A-2,2',6,6'-d4 是 BISPHENOL-A 的氘代化合物。BISPHENOL-A 的 CAS 号为 80-05-7。Bisphenol A 是酚类有机合成化合物，广泛用于环氧树脂和聚碳酸酯塑料的生产。它是生殖、发育和全身毒性物质，常被归类为内分泌干扰物。它与许多疾病有关，包括呼吸系统疾病、心血管疾病、糖尿病、肾脏疾病、肥胖和生殖障碍。
TMID-0092 BISPHENOL-A-3,3',5,5'-d4

BISPHENOL-A-3,3',5,5'-d4 是 BISPHENOL-A 的氘代化合物。BISPHENOL-A 的 CAS 号为 80-05-7。Bisphenol A 是酚类有机合成化合物，广泛用于环氧树脂和聚碳酸酯塑料的生产。它是生殖、发育和全身毒性物质，常被归类为内分泌干扰物。它与许多疾病有关，包括呼吸系统疾病、心血管疾病、糖尿病、肾脏疾病、肥胖和生殖障碍。
TMIH-0521 Silibinin-d3

Silibinin-d3 是 Silibinin 的氘代化合物。Silibinin 的 CAS 号为 22888-70-6。Silibinin 是水飞蓟的主要活性成分，具有抗癌和化疗预防作用，能抑制细胞增殖和迁移。

同位素标记化合物

Ospemifene D4
Cat.No: T12329
Synonym: FC-1271a D4
Target: Estrogen/progestogen Receptor
Tamoxifen-​d5
Cat.No: T13076
Synonym: ICI 47699-​d5,(Z)-Tamoxifen-​d5,trans-Tamoxifen-​d5
Target: HSP
17β-estradiol-d4
Cat.No: TMID-0055
Synonym:
Target:
17β-Estradiol-2,4-d2
Cat.No: TMIJ-0028
Synonym:
Target:
17beta-Estradiol-13C2
Cat.No: TMIJ-0032
Synonym:
Target:
Dienestrol-d6
Cat.No: TMID-0024
Synonym:
Target:
17β-Estradiol-2,4,16,16,17-d5
Cat.No: TMID-0108
Synonym:
Target:
α-Zearalenol-d5
Cat.No: TMIJ-0038
Synonym:
Target:
17β-Estradiol-16,16,17-d3
Cat.No: TMIJ-0196
Synonym:
Target:
2-Methoxyestrone-1,4,16,16-d4
Cat.No: TMID-0140
Synonym:
Target:
17alpha-Estradiol-2,4-d2
Cat.No: TMIJ-0040
Synonym:
Target:
Fulvestrant-d3
Cat.No: TMIJ-0244
Synonym:
Target:
Estriol-d3
Cat.No: TMIJ-0280
Synonym:
Target:
16α-Hydroxy-17β-estradiol-2,4-d2
Cat.No: TMIJ-0035
Synonym:
Target:
Estrone-d2
Cat.No: TMIJ-0313
Synonym:
Target:
BISPHENOL A-d16
Cat.No: TMID-0091
Synonym:
Target:
Estrone-d4
Cat.No: TMIJ-0255
Synonym: Estriol EP Impurity B-d4
Target:
Zearalenone-13C18
Cat.No: T35783
Synonym: Zearalenone-13C18
Target:
BISPHENOL-A-2,2',3,3',5,5',6,6'-d8
Cat.No: TMID-0090
Synonym:
Target:
BISPHENOL-A-2,2',6,6'-d4
Cat.No: TMID-0093
Synonym:
Target:
BISPHENOL-A-3,3',5,5'-d4
Cat.No: TMID-0092
Synonym:
Target:
Silibinin-d3
Cat.No: TMIH-0521
Synonym:
Target:
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