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Targets Recommended: Kinesin

1

抑制剂 & 化合物

12

天然产物

1

化合物库

8

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name
L8200	抗衰老化合物库		3279 compounds
	3279 个抗衰老化合物的独特集合，可用于高通量筛选和高内涵筛选；

化合物库

抗衰老化合物库

Cat.No: L8200

Compounds: 3279

Cat. No.	Product Name	Target	Signaling Pathways
T29059	UMK57 UMK 57,UMK-57	Kinesin	Cytoskeletal Signaling
	UMK57 是一种CENP-Ei、MCAK 增强剂，选择性促进 k-MT 附着错误纠正以抑制染色体错误分离的小分子化合物，可以通过破坏有丝分裂过程中动粒微管 (k-MT) 附着的稳定性来提高染色体分离保守性。

化合物

Cat.No: T29059

Synonym: UMK 57,UMK-57

Target: Kinesin

Cat. No.	Product Name	Target	Signaling Pathways
T4766	3-Methylglutaric acid	Endogenous Metabolite	Metabolism
	3-Methylglutaric acid 是亮氨酸代谢物，是一种与两种亮氨酸途径 HMGCL、AUH 酶缺陷显著相关的 C6 二元羧酸有机酸。
T5291	Malonic acid Carboxyacetic Acid,1,3-Propanedioic Acid,丙二酸,Propanedioic Acid	Others	Others
	Malonic acid (propanedioic acid) 是竞争性抑制剂的典型例子：它作用于呼吸电子传递链中的琥珀酸脱氢酶(复合物 II)。发现丙二酸与丙二酰辅酶A 脱羧酶缺乏有关，这是一种先天性代谢错误。
T4872	Palmitoleic acid 棕榈油酸,(Z)-Hexadec-9-enoic acid,(Z)-9-hexadecenoic acid	Endogenous Metabolite	Metabolism
	Palmitoleic acid ((Z)-Hexadec-9-enoic acid) 是脂肪酸的组成部分，能够预防 SHRSP 大鼠因脑血管疾病引起的死亡。
T5251	Phenylpyruvic acid 2-Oxo-3-phenylpropanoic acid,3-Phenylpyruvic acid,苯丙酮酸	Others; Endogenous Metabolite	Metabolism; Others
	Phenylpyruvic acid (3-Phenylpyruvic acid) 可以通过乳酸脱氢酶合成3-苯基乳酸 (PLA)。
T37177	Norcholic Acid	Others	Others
	Norcholic acid is a bile acid and 23-carbon derivative of cholic acid .1Levels of norcholic acid are increased in the urine of patients with liver cirrhosis or cerebrotendinous xanthomatosis (CTX), an inborn error of metabolism characterized by a deficiency in the mitochondrial enzyme sterol 27-hydrolylase (CYP27A1) that leads to progressive neurological symptoms.2,3,4
T4829	3-Hydroxyphenylacetic acid	Others; Endogenous Metabolite	Metabolism; Others
	3-Hydroxyphenylacetic acid 是内源性代谢产物的一种。
T4843	2,2-Dihydroxyacetic acid Formylformic acid,Glyoxylic acid monohydrate,乙醛酸水合物	Others; Endogenous Metabolite	Metabolism; Others
	2,2-Dihydroxyacetic acid (Formylformic acid) 是乙醛酸循环的中间体，使某些生物体能够将脂肪酸转化为碳水化合物。2,2-Dihydroxyacetic acid 被发现与原发性高草酸尿有关，这是一种先天性代谢错误。作为一种醛，乙醛酸酯也具有高活性，可以修饰蛋白质形成晚期糖基化产物(AGEs)。
T4887	3-Amino-2-methylpropanoic acid DL-3-AMINOISOBUTYRIC ACID,3-氨基异丁酸,α-Methyl-β-alanine	Endogenous Metabolite	Metabolism
	3-Amino-2-methylpropanoic acid (α-Methyl-β-alanine) 是 N-carbamyl-beta-aminoisobutyric acid 经 enzyme Beta-ureidopropionase (EC 3.5.1.6)转化后的产物，是嘧啶降解的最后一步。-尿嘧啶丙酸酶缺乏症是一种与神经异常相关的嘧啶降解的先天性错误。
T4867	Erucic acid Prifac 2990,芥酸,13(Z)-Docosenoic Acid,cis-13-docosenoic acid	PI3K; Endogenous Metabolite	Metabolism; PI3K/Akt/mTOR signaling
	Erucic acid (13(Z)-Docosenoic Acid) 是单不饱和脂肪酸，分离自萝卜的种子。Erucic acid 可以容易地穿过血脑屏障，使大脑中长链脂肪酸的积累正常化。Erucic acid 能够改善认知障碍并有效预防痴呆。
T4848	Mandelic acid acidomandelico,DL-Mandelic acid,扁桃酸	Others; Endogenous Metabolite; Antibacterial	Metabolism; Microbiology/Virology; Others
	DL-Mandelic acid (acidomandelico) 是一种 α-羟基羧酸，有抗菌活性，广泛用作医药和精细化学品的中间体，已用于研究尿路感染和阴道滴虫病，还具有较高的精子固定活性和较低的阴道刺激性。
T4858	4-Hydroxyphenylpyruvic acid 4-羟苯基丙酮酸,4-Hydroxyphenylpyruvic acid	Endogenous Metabolite	Metabolism
	4-Hydroxyphenylpyruvic acid 是一种苯丙氨酸代谢的中间产物，是一种酶抑制剂。
T19281	Dihydroxyacetone phosphate	Others	Others
	Dihydroxyacetone phosphate is an important intermediate for lipid biosynthesis and glycolysis. It is a biochemical compound involved in many metabolic pathways, including the Calvin cycle and glycolysis in plants. It was found that dihydroxyacetone phosph

天然产物

3-Methylglutaric acid

Cat.No: T4766

Target: Endogenous Metabolite

Cat.No: T5291

Synonym: Carboxyacetic Acid,1,3-Propanedioic Acid,丙二酸,Propanedioic Acid

Target: Others

Palmitoleic acid

Cat.No: T4872

Synonym: 棕榈油酸,(Z)-Hexadec-9-enoic acid,(Z)-9-hexadecenoic acid

Target: Endogenous Metabolite

Phenylpyruvic acid

Cat.No: T5251

Synonym: 2-Oxo-3-phenylpropanoic acid,3-Phenylpyruvic acid,苯丙酮酸

Target: Others, Endogenous Metabolite

Cat.No: T37177

Target: Others

3-Hydroxyphenylacetic acid

Cat.No: T4829

Target: Others, Endogenous Metabolite

2,2-Dihydroxyacetic acid

Cat.No: T4843

Synonym: Formylformic acid,Glyoxylic acid monohydrate,乙醛酸水合物

Target: Others, Endogenous Metabolite

3-Amino-2-methylpropanoic acid

Cat.No: T4887

Synonym: DL-3-AMINOISOBUTYRIC ACID,3-氨基异丁酸,α-Methyl-β-alanine

Target: Endogenous Metabolite

Cat.No: T4867

Synonym: Prifac 2990,芥酸,13(Z)-Docosenoic Acid,cis-13-docosenoic acid

Target: PI3K, Endogenous Metabolite

Cat.No: T4848

Synonym: acidomandelico,DL-Mandelic acid,扁桃酸

Target: Others, Endogenous Metabolite, Antibacterial

4-Hydroxyphenylpyruvic acid

Cat.No: T4858

Synonym: 4-羟苯基丙酮酸,4-Hydroxyphenylpyruvic acid

Target: Endogenous Metabolite

Dihydroxyacetone phosphate

Cat.No: T19281

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02707	PAH Protein, Human, Recombinant (415 Asn/Asp, His) phenylalanine hydroxylase,PH,PKU1,PKU	Human	Baculovirus Insect Cells
	PAH (phenylalanine hydroxylase), also known as PH, belongs to the biopterin-dependent aromatic amino acid hydroxylase family. It contains 1 ACT domain, N-terminal region of PAH is thought to contain allosteric binding sites for phenylalanine and to constitute an "inhibitory" domain that regulates the activity of a catalytic domain in the C-terminal portion of the molecule. In humans, PAH is expressed both in the liver and the kidney, and there is some indication that it may be differentially reg...
TMPH-00427	DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant DNA polymerase IV,dinB,Pol IV	Colwellia psychrerythraea	E. coli
	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant is expressed in E. coli expression syste...
TMPJ-00863	GNS Protein, Human, Recombinant (His) N-Acetylglucosamine-6-Sulfatase,G6S,GNS,Glucosamine-6-Sulfat...	Human	HEK293 Cells
	N-Acetylglucosamine-6-Sulfatase is a member of the Sulfatase family. N-Acetylglucosamine-6-Sulfatase is required for the lysosomal degradation of the Glycosaminoglycans (GAG) Heparan Sulfate and Keratan Sulfate. N-Acetylglucosamine-6-Sulfatase hydrolyzes the 6-Sulfate groups of the N-Acetyl-D-Glucosamine 6-Sulfate units of Heparan Sulfate and Keratan Sulfate. N-Acetylglucosamine-6-Sulfatase binds 1 Calcium ion per subunit. N-Acetylglucosamine-6-Sulfatase deficiency are the cause of Mucopolysacch...
TMPH-00426	DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant (His) dinB,DNA polymerase IV,Pol IV	Colwellia psychrerythraea	E. coli
	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant (His) is expressed in E. coli expression...
TMPJ-01131	UBE2V2 Protein, Human, Recombinant (His) Enterocyte Differentiation-Associated Factor 1,Vitamin D3-In...	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 Variant 2 (UBE2V2) is an enzyme that belongs to the ubiquitin-conjugating enzyme family. UBE2V2 can be detected in the placenta, colon, liver, and skin. It forms a heterodimer with UBE2N. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains and which leads to protein degradation by the proteasome. UBE2V2 mediates transcriptional activation of target genes. It plays a role in the control of progress through the cell cycle and...
TMPJ-01100	UBE2V1 Protein, Human, Recombinant (His) TRAF6-Regulated IKK Activator 1 Beta Uev1A,P/OKcl.19,TRAF6-R...	Human	E. coli
	Ubiquitin-Conjugating Enzyme Variant 1a (UBE2V1) is a member of the Ubiquitin-conjugating (E2) enzyme family. The E2 catalytic core domain of UBE2V1 lacks an active site cysteine residue, rendering it catalytically inactive on its own. However, in the cytoplasm UBE2V1 is able to form a catalytically active complex with UBE2N/Ubc13, which mediates the synthesis Lys63-linked Ubiquitin chains and is required for NF-kappa B activation. UBE2V1 is required for UBE2N (Ubc13)/UBE2V1 Complex-dependent Ly...
TMPH-01238	POLQ Protein, Human, Recombinant (His) DNA polymerase eta,POLQ,DNA polymerase theta	Human	Baculovirus Insect Cells
	DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA. MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation. POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumul...
TMPH-01237	POLQ Protein, Human, Recombinant (E. coli, His) DNA polymerase eta,POLQ,DNA polymerase theta	Human	E. coli
	DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA. MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation. POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumul...

重组蛋白

PAH Protein, Human, Recombinant (415 Asn/Asp, His)

Cat.No: TMPY-02707

Species: Human

Expression System: Baculovirus Insect Cells

DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant

Cat.No: TMPH-00427

Species: Colwellia psychrerythraea

Expression System: E. coli

GNS Protein, Human, Recombinant (His)

Cat.No: TMPJ-00863

Species: Human

Expression System: HEK293 Cells

DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant (His)

Cat.No: TMPH-00426

Species: Colwellia psychrerythraea

Expression System: E. coli

UBE2V2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01131

Species: Human

Expression System: E. coli

UBE2V1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01100

Species: Human

Expression System: E. coli

POLQ Protein, Human, Recombinant (His)

Cat.No: TMPH-01238

Species: Human

Expression System: Baculovirus Insect Cells

POLQ Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-01237

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T35698	Octanoic Acid-13C
	Octanoic acid-13C is intended for use as an internal standard for the quantification of octanoic acid by GC- or LC-MS. Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from goat, ovine, or bovine milk.1 Octanoic acid is active against the bacteria S. mutans, S. gordonii, F. nucleatum, and P. gingivalis (IC80s = <125, <125, 1,403, and 2,294 μM, respectively).2 Levels of octanoic acid are increased in the plasma of patients with medium-chain acyl-CoA d...
TMID-0056	(±)-Mandelic-2,3,4,5,6-d5 Acid
	(±)-Mandelic-2,3,4,5,6-d5 Acid 是 (±)-Mandelic Acid 的氘代化合物。(±)-Mandelic Acid 的 CAS 号为 90-64-2。DL-Mandelic acid 是一种 α-羟基羧酸，有抗菌活性，广泛用作医药和精细化学品的中间体，已用于研究尿路感染和阴道滴虫病，还具有较高的精子固定活性和较低的阴道刺激性。

同位素标记化合物

Octanoic Acid-13C

Cat.No: T35698

(±)-Mandelic-2,3,4,5,6-d5 Acid

Cat.No: TMID-0056

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