首页工具

登录

搜索结果

Search Results for " endocannabinoid "

Targets Recommended: Lipase

28

抑制剂 & 化合物

2

天然产物

3

重组蛋白

2

同位素标记化合物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T9687	MAGL-IN-4 His121 ARG57	Lipase	Metabolism
	MAGL-IN-4 (His121 ARG57) 是选择性的、口服有效的、可透过血脑屏障的、可逆的单酰基甘油脂肪酶抑制剂，IC50=6.2 nM。它主要通过大脑中选择性抑制 MAGL 增加 2-花生四烯酰甘油水平来增强内源性大麻素信号。
T8425	Linoleoyl Ethanolamide	TRP/TRPV Channel	Membrane transporter/Ion channel
	Linoleoyl ethanolamide 是脂肪酸乙醇酰胺。它可弱结合 CB1 和 CB2 受体，并分别抑制[3H]CP-55,940的结合，Ki 分别为 10 和 25μM。它在引起小鼠过氧化氢酶方面的效力是 anandamide 的4倍，且对睡眠时间无延长效果。
T3354	BIA 10-2474 BIA10-2474	FAAH; Autophagy	Autophagy; Metabolism; Neuroscience
	BIA 10-2474 是一种长效可逆的脂肪酸酰胺水解酶抑制剂，与人类内源性大麻素系统相互作用，可增加中枢神经系统和外周组织，对大鼠大脑不同区域的 IC50值为50至70mg/kg。它用于治疗焦虑症、帕金森氏病和多发性硬化症、高血压或肥胖症的慢性疼痛。
T23494	UCM 707	Others	Others
	endocannabinoid transport inhibitor
T84458	Tricosanoyl Ethanolamide	Others	Others
	Tricosanoyl ethanolamide, a fatty N-acyl ethanolamine within the endocannabinoid family, has an ethanolamine metabolite whose significance remains to be established.
T69740	AMG-315	Others	Others
	AMG-315 is a Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes. AMG-315 is a chiral arachidonoyl ethanolamide (AEA) analogue or (13S,1′R)-dimethylanandamide. AMG-315 is a high affinity ligand for the CB1 receptor (Ki of 7.8 ± 1.4 nM) that behaves as a potent CB1 agonist in vitro (EC50 = 0.6 ± 0.2 nM). AMG-315 is the first potent AEA analogue with significant stability for all endocannabinoid hydrolyzing enzymes as well as the oxidative enzymes COX-2. AMG-315 will serve as a ...
T84459	γ-Linolenoyl monoethanolamide	Others	Others
	γ-Linolenoyl monoethanolamide，一种脂肪N-酰乙醇胺，属于内源性大麻素。
T69899	WOBE437	Others	Others
	WOBE437 is a selective endocannabinoid reuptake inhibitor which reduces disease progression in a mouse model of multiple sclerosis
T84461	Lignoceroyl Ethanolamide	Others	Others
	Lignoceroyl ethanolamide, a fatty N-acyl ethanolamine within the endocannabinoid family, is derived from lignoceric acid, which is found in relatively high concentrations in rat cerebrospinal fluid. However, the specific function and significance of this metabolite remain unclear.
T37684	CAY10412 CAY10412	Others	Others
	Anandamide (arachidonoyl ethanolamide; AEA) is an endogenous lipid with cannabinergic activity; along with 2-arachidonoyl glycerol, it forms part of the endocannabinoid system. AEA undergoes reuptake into neurons by a facilitated process. Controversy exists as to whether there is a specific AEA transporter, or instead the uptake process is simply driven by hydrolysis of AEA by intracellular fatty acyl amide hydrolase (FAAH). CAY10412 is an analog of AEA that has no intrinsic binding affinity for...
T84630	N-Linolenoylethanolamine α-Linolenoyl ethanolamide,18:3 NAE	Others	Others
	N-Linolenoylethanolamine (18:3 NAE) 为一种内源性大麻素，同时也是香草素受体(TRPV1)的激动剂。
T84648	2-Linoleoyl Glycerol 2-LG	Others	Others
	2-Arachidonoyl glycerol (2-AG), a natural endocannabinoid ligand for the CB1 receptor, was isolated from porcine brain and characterized. Its congener, 2-linoleoyl glycerol (2-LG), which has a linoleoyl group instead of an arachidonoyl group, also exists alongside 2-AG in vivo. While 2-LG exhibits low intrinsic activity, it enhances the activity of 2-AG and other endocannabinoids through an "entourage" effect, attributed to the inhibition of breakdown and reuptake pathways that typically decreas...
T35408	(±)10(11)-EDP Ethanolamide	Others	Others
	(±)10(11)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 0.43 and 22.5 nM for CB1 and CB2 receptors, respectively). It is produced though direct epoxygenation of docosahexaenoyl ethanolamide by cytochrome P450 (CYP) epoxygenases. 10,11-EDP epoxide (12.5 and 25 μM) reduces the viability of 143B metastatic osteosarcoma cells. It induces apoptosis and inhibits cell migration in a wound-healing assay in 143B, MG63, and HOS osteosarcoma cells. (±)10(...
T77212	L-α-lysophosphatidylinositol (Soy) (sodium)	Others	Others
	L-α-lysophosphatidylinositol Soy sodium 作为GPR55的内源性配体，是一种既属于内源性溶血磷脂也是内源性大麻素神经递质的化合物。
T60957	Palmitoyl serinol	Others	Others
	Palmitoyl serinol (N-Palmitoyl serinol) 是内源性大麻素 N-棕榈酰乙醇胺(PEA) 的类似物，可改善正常和发炎皮肤的表皮通透性屏障。
T84545	N-Palmitoyl Taurine	Others	Others
	N-Palmitoyl taurine, an amino-acyl endocannabinoid prominent in rat brain lipidomics profiling, accompanies multiple arachidonoyl amino acids isolated from bovine brain, including N-arachidonoylethanolamine (NADA) and N-arachidonoyl serine (ARA-S). Mass spectral lipidomic analysis of rat brain additionally revealed a series of fatty acyl amides with taurine. The function of N-Palmitoyl taurine is under investigation.
T36065	N-Oleoyl-L-Serine
	Bone mass and shape is continuously remodeled by the concerted and balanced action of osteoblasts (bone forming cells) and osteoclasts (bone-resorbing cells). The endocannabinoid system plays an essential role in the maintenance of normal bone mass via signaling through the CB2 receptor. N-Oleoyl-L-serine is an endogenous lipid that has been reported to stimulate bone formation and to inhibit bone resorption.
T64371	Virodhamine O-arachidonoyl ethanolamine	Cannabinoid Receptor	GPCR/G Protein
	Virodhamine (O-arachidonoyl ethanolamine) 是一种内源性大麻素，是CB1受体的拮抗剂和CB2受体的激动剂。Virodhamine 可用于阿尔茨海默病等神经系统疾病的研究。
T39281	AM404	Others	Others
	AM404 is a chemical compound that functions as an inhibitor of endocannabinoid reuptake. It effectively blocks the transport of anandamide, with IC50 values measured in the low micromolar range. Moreover, AM404 exhibits the ability to induce relaxation in rat isolated hepatic arteries contracted with Phenylephrine. This relaxation effect is quantified by a pEC50 value of 7.4 (corresponding to an EC50 of 0.04 μM). Additionally, AM404 possesses a neuroprotective effect.
T84637	Prostaglandin E2-1-glyceryl ester PGE2-1-glyceryl ester	Others	Others
	Prostaglandin E2-1-glyceryl ester，前列腺素甘油酯类，作为CB1受体内源性大麻素配体，能诱导细胞内游离Ca2+迅速、瞬时升高。
T84548	N-Oleoyl Taurine	Others	Others
	N-Oleoyl taurine, an amino-acyl endocannabinoid isolated from rat brain, along with several arachidonoyl amino acids such as N-arachidonoyl dopamine and N-arachidonoyl serine, have been derived from bovine brain. Mass spectral lipidomics analysis of rat brain revealed a series of fatty acyl amides of taurine, marking the discovery of a new class of compounds. These compounds, found in the kidney, are known to activate members of the transient receptor potential (TRP) family of calcium channels, ...
T35786	O-7460	Others	Others
	In humans, two forms of diacylglycerol lipase, DAGLα and DAGLβ, generate the endocannabinoid 2-arachidonoyl glycerol by attacking DAG at the sn-1 position. O-7460 is a selective inhibitor of 2-AG biosynthesis via DAGLα (IC50 = 690 nM). It demonstrates much weaker inhibition towards human monoacylglycerol lipase and rat brain fatty acid amide hydrolase (IC50s > 10 μM) and does not bind to CB1 or CB2 cannabinoid receptors (Kis > 10 μM). At 0-12 mg/kg, i.p. in mice, O-7460 was reported to dose-depe...
T84546	N-Stearoyl Taurine	Others	Others
	N-Arachidonoyl dopamine (NADA) and N-Arachidonoyl serine (ARA-S), among various arachidonoyl amino acids, have been extracted from bovine brain, while a novel series of fatty acyl amides of taurine were unearthed in rat brain through mass spectral lipidomic analysis, indicating the discovery of a new class of compounds also located in the kidney. These compounds are known to activate members of the transient receptor potential (TRP) family of calcium channels. Notably, N-Stearoyl taurine emerges...
T84543	Arachidoyl Ethanolamide N-Arachidoylethanolamine	Others	Others
	Arachidoyl ethanolamide, a saturated fatty acyl ethanolamide lacking classical (CB1/CB2) activity, plays a role in a complex system comprising central cannabinoid (CB1), peripheral cannabinoid (CB2), and non-CB receptor-mediated pharmacology. This system has paved the way for extensive research in diverse fields such as memory, weight loss and appetite, neurodegeneration, tumor surveillance, analgesia, and inflammation. Unlike other compounds, Arachidoyl ethanolamide does not bind to the murine ...
T84551	N-Arachidonoyl-L-Serine ARA-S	Others	Others
	N-Arachidonoyl-L-serine (ARA-S), a recently isolated endocannabinoid with a distinct activity profile that diverges from typical endocannabinoids, does not interact with central cannabinoid (CB1), peripheral cannabinoid (CB2) receptors, or vanilloid receptor 1 (VR1). Unlike other compounds, ARA-S (5 mg/kg) counteracts the lowering of blood pressure induced by a 10 mg/kg intravenous bolus of abnormal cannabidiol (Abn-CBD) in anesthetized rat models. Additionally, akin to Abn-CBD, ARA-S induces re...
T85120	(±)17(18)-EpETE-Ethanolamide (±)17(18)-EpETE-EA,(±)17,18-EEQ-Ethanolamide,17,18-EEQ-EA,17,18-epoxy-Eicosatetraenoic Acid Ethanolamide	Others	Others
	(±)17(18)-EpETE-Ethanolamide, an ω-3 endocannabinoid epoxide, originates from eicosapentaenoic ethanolamide (EPEA) through cytochrome P450 (CYP) epoxygenases action and is decomposed by soluble epoxide hydrolase (sEH) and fatty acid amide hydrolase (FA, AH). Its endogenous synthesis occurs in LPS-stimulated and EPEA-supplemented BV-2 microglia cells, a process inhibited by the CYP inhibitor ketoconazole. This compound mitigates IL-6 and nitrite levels while enhancing IL-10 production following L...
T75022	JZP-MA-11	Others	Others
	JZP-MA-11是一种用于正电子发射断层扫描(PET)的配体，专一性靶向内源性大麻素α/β-水解酶结构域6(ABHD6)酶，并具有126 nM的IC50值，表明其对ABHD6有选择性抑制作用。JZP-MA-11能有效穿过血脑屏障(BBB)。[18F]JZP-MA-11展现出在靶向小鼠及非人灵长类(NHP)大脑ABHD6方面的临床前评估潜力。
T35468	(±)19(20)-EDP Ethanolamide	Others	Others
	(±)19(20)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively). It is produced through direct epoxygenation of docosahexaenoyl ethanolamide by cytochrome P450 (CYP) epoxygenases. (±)19(20)-EDP ethanolamide (25 μM) reduces the viability of 143B metastatic osteosarcoma cells. It decreases the production of IL-6 and increases the production of IL-10 when used at concentrations ranging from 2.5 to 10 μM in BV-...

化合物

Cat.No: T9687

Synonym: His121 ARG57

Target: Lipase

Linoleoyl Ethanolamide

Cat.No: T8425

Target: TRP/TRPV Channel

Cat.No: T3354

Synonym: BIA10-2474

Target: FAAH, Autophagy

Cat.No: T23494

Target: Others

Tricosanoyl Ethanolamide

Cat.No: T84458

Target: Others

Cat.No: T69740

Target: Others

γ-Linolenoyl monoethanolamide

Cat.No: T84459

Target: Others

Cat.No: T69899

Target: Others

Lignoceroyl Ethanolamide

Cat.No: T84461

Target: Others

Cat.No: T37684

Synonym: CAY10412

Target: Others

N-Linolenoylethanolamine

Cat.No: T84630

Synonym: α-Linolenoyl ethanolamide,18:3 NAE

Target: Others

2-Linoleoyl Glycerol

Cat.No: T84648

Synonym: 2-LG

Target: Others

(±)10(11)-EDP Ethanolamide

Cat.No: T35408

Target: Others

L-α-lysophosphatidylinositol (Soy) (sodium)

Cat.No: T77212

Target: Others

Palmitoyl serinol

Cat.No: T60957

Target: Others

N-Palmitoyl Taurine

Cat.No: T84545

Target: Others

N-Oleoyl-L-Serine

Cat.No: T36065

Cat.No: T64371

Synonym: O-arachidonoyl ethanolamine

Target: Cannabinoid Receptor

Cat.No: T39281

Target: Others

Prostaglandin E2-1-glyceryl ester

Cat.No: T84637

Synonym: PGE2-1-glyceryl ester

Target: Others

N-Oleoyl Taurine

Cat.No: T84548

Target: Others

Cat.No: T35786

Target: Others

N-Stearoyl Taurine

Cat.No: T84546

Target: Others

Arachidoyl Ethanolamide

Cat.No: T84543

Synonym: N-Arachidoylethanolamine

Target: Others

N-Arachidonoyl-L-Serine

Cat.No: T84551

Synonym: ARA-S

Target: Others

(±)17(18)-EpETE-Ethanolamide

Cat.No: T85120

Synonym: (±)17(18)-EpETE-EA,(±)17,18-EEQ-Ethanolamide,17,18-EEQ-EA,17,18-epoxy-Eicosatetraenoic Acid Ethanolamide

Target: Others

Cat.No: T75022

Target: Others

(±)19(20)-EDP Ethanolamide

Cat.No: T35468

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T14046	Anandamide 花生四烯酸乙醇胺,(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide	Cannabinoid Receptor; Endogenous Metabolite	GPCR/G Protein; Metabolism
	Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide) 是一种免疫调节剂，通过大麻素受体 CB1 和 CB2 起作用，还通过中枢神经系统中的其他靶点起作用，如 GPR18/GPR55。
TN3575	(±)-Cannabichromene Cannabichromene,大麻色原烯,Cannabichrome	Cannabinoid Receptor	GPCR/G Protein
	(±)-Cannabichromene 是一种发现于大麻的 2,2-dimethyl-2H-chromene 衍生物。

天然产物

Cat.No: T14046

Synonym: 花生四烯酸乙醇胺,(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide

Target: Cannabinoid Receptor, Endogenous Metabolite

(±)-Cannabichromene

Cat.No: TN3575

Synonym: Cannabichromene,大麻色原烯,Cannabichrome

Target: Cannabinoid Receptor

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01298	EPHX1 Protein, Human, Recombinant (His) EPHX1,Microsomal epoxide hydrolase,Epoxide hydratase,Epoxide...	Human	E. coli
	Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Plays a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol.
TMPH-03337	MGLL Protein, Rat, Recombinant (His) Mgll,Monoacylglycerol lipase,Monoglyceride lipase	Rat	P. pastoris (Yeast)
	Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth. MGLL Protein, Rat, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 34.8 kDa and the accession nu...
TMPH-01325	FAAH2 Protein, Human, Recombinant (His) Amidase domain-containing protein,Anandamide amidohydrolase ...	Human	E. coli
	Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules. Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates. FAAH2 Protein, Human, Recombinant (His) is expressed in E. coli e...

重组蛋白

EPHX1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01298

Species: Human

Expression System: E. coli

MGLL Protein, Rat, Recombinant (His)

Cat.No: TMPH-03337

Species: Rat

Expression System: P. pastoris (Yeast)

FAAH2 Protein, Human, Recombinant (His)

Cat.No: TMPH-01325

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0620	Arachidonoyl Ethanolamide-d4 AEA-d4
	Deuterated anandamide, a synthetically modified version of anandamide where hydrogen atoms are replaced with deuterium (D), exhibits enhanced stability against oxidative degradation. This modification conserves the compound's pharmacological properties while prolonging its shelf life and efficacy in research applications, particularly in analytical and biochemical studies to elucidate the complex mechanisms of the endocannabinoid system.
T70882	Orlistat-d3
	Orlistat-d3 is intended for use as an internal standard for the quantification of orlistat by GC- or LC-MS. Orlistat is a digestive lipase inhibitor. It inhibits diacylglycerol lipase α (DAGLα), DAGLβ, α/β-hydrolase domain-containing protein 12 (ABHD12), ABHD16A, and platelet-activating factor acetylhydrolase (PAF-AH; IC50s = 0.06, 0.1, 0.08, 0.03, and 0.05 µM, respectively), as well as pancreatic lipase and hormone-sensitive lipase (IC50s = 0.65 and 2.1 µg/ml, respectively) but does not inhibit...

同位素标记化合物

Arachidonoyl Ethanolamide-d4

Cat.No: TMIH-0620

Synonym: AEA-d4

Cat.No: T70882

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼