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抑制剂 & 化合物

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Cat. No. Product Name
L4300 Wnt/Hedgehog/Notch 通路化合物库

237 compounds
237 个Wnt & Hedgehog & Notch 靶点相关的生物活性小分子化合物的特有集合,用于相关通路的研究及药物的筛选,可用于高通量、高内涵筛选。
L1380 转录因子库

695 compounds
695 种转录因子靶向、结构新颖的化合物;
L4100 TGF-β/Smad靶点化合物库

184 compounds
184 个 TGF-β/Smad 靶点相关的小分子化合物的特有集合,用于高通量、高内涵筛选;
L8000 干细胞分化化合物库

1197 compounds
1197 种干细胞分化信号通路相关的生物活性小分子化合物的特有集合,可用于高通量、高内涵筛选;

化合物库

Wnt/Hedgehog/Notch 通路化合物库
Cat.No: L4300
Compounds: 237
转录因子库
Cat.No: L1380
Compounds: 695
TGF-β/Smad靶点化合物库
Cat.No: L4100
Compounds: 184
干细胞分化化合物库
Cat.No: L8000
Compounds: 1197
Cat. No. Product Name Target Signaling Pathways
T27246 EG1

Others Others
EG1 是特异性 Pax2<.b> 抑制剂,能够直接结合 Pax2 的配对结构域 (Kd:1.35-1.5 μM) ,可阻碍 Pax2-DNA 相互作用。它能够抑制胚胎肾脏发育,此过程直接依赖于 Pax2活性。
T11996 MELK-8a hydrochloride

MELK PI3K/Akt/mTOR signaling
MELK-8a hydrochloride 是一种有效的母体胚胎亮氨酸拉链激酶抑制剂,IC50 为 2 nM。
T16695 Pyrintegrin

Integrin Cytoskeletal Signaling
Pyrintegrin 是一种 β1 整合素激动剂,也是 2,4-二取代的嘧啶,可促进胚胎干细胞存活。它可用作足细胞保护剂,能增强细胞-细胞外基质 (ECM) 粘附介导的整联蛋白信号传导,具有强大的成脂作用。
T8987 Epiblastin A

Casein Kinase Metabolism; Stem Cells
Epiblastin A 是 ATP 竞争性的酪蛋白激酶 1 (CK1) 抑制剂,能够抑制 CK1α (IC50:8.9 µM)、 CK1δ (IC50:0.5 µM)、CK1 ɛ (IC50:4.7 µM)。它能够抑制 CK1 诱导外胚层干细胞重编程为胚胎干细胞。
T24706 RBC10

RBC 10,RBC-10

GTPase GPCR/G Protein
RBC10 抑制 Ral 与其效应物 RALBP1 的结合,以及抑制 Ral 介导的鼠胚胎成纤维细胞的细胞扩散和人类癌细胞系的非贴壁依赖性生长。
T38155 N-Acetyl-D-cysteine

Reactive Oxygen Species Immunology/Inflammation; Metabolism; NF-κB
N-Acetyl-D-cysteine 具有抗氧化活性,机制是通过与巯基反应清除ROS。N-Acetyl-D-cysteine 不能进入谷胱甘肽代谢途径。
T9681 MAK-683 hydrochloride

Histone Methyltransferase Chromatin/Epigenetic
MAK683 hydrochloride 是胚胎外胚层发育 (EED) 抑制剂。MAK683 hydrochloride 在 EED Alphascreen, ELISA 和 LC-MS 试验中测得的IC50 值分别为 59,26,89 nM。
T21981 Phthalazinone pyrazole

Aurora Kinase Cell Cycle/Checkpoint; Chromatin/Epigenetic
Phthalazinone pyrazole 是强效、选择性和口服生物可利用的 Aurora-A 激酶抑制剂,IC50值为 0.031 μM。它抑制人胚胎干细胞向肝细胞样细胞分化过程中的上皮间质转化。它还可阻止有丝分裂并随后通过增殖细胞的凋亡抑制肿瘤生长。
T1759 OTSSP167

MELK inhibitor,OTS167

MELK PI3K/Akt/mTOR signaling
OTSSP167 (OTS167) 是一种高效的,ATP 竞争性的 MELK 抑制剂,其 IC50=0.41 nM。
T6848 GSK1016790A

GSK101

Calcium Channel; TRP/TRPV Channel Membrane transporter/Ion channel; Metabolism
GSK1016790A (GSK101) 是选择性瞬时受体电位香草酸 4 通道激活剂,可引起 HEK 细胞中 Ca2+流入并升高细胞内 Ca2+。
T1874 PPQ-102

PPQ102,CFTR Inhibitor,PPQ 102

CFTR; Autophagy Autophagy; Membrane transporter/Ion channel
PPQ-102 (CFTR Inhibitor) 是一种CFTR 抑制剂,可以完全抑制CFTR 氯化物电流,IC50为90 nM。
T2431 ID-8

ID8

DYRK Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
ID-8 是 DYRK 抑制剂,长时间培养能够维持胚胎干细胞的自我更新。
T11997 MELK-IN-1

Nintedanib Impurity L,MELK inhibitor 17,尼达尼布杂质L

MELK PI3K/Akt/mTOR signaling
MELK-IN-1 (MELK inhibitor 17)是一种母体胚胎亮氨酸拉链激酶的有效抑制剂,IC50=3 nM,Ki=0.39 nM。
T21559 OTSSP167 hydrochloride

OTSSP 167 盐酸盐

MELK PI3K/Akt/mTOR signaling
OTSSP167 hydrochloride 是一种高效的,ATP 竞争性的MELK 抑制剂,其 IC50=0.41 nM。
T3221 Oct3/4-inducer-1

2-(4-(4-methoxybenzyloxy)phenyl)acetonitrile,2-(4-[(4-甲氧基苄基)氧基]苯基)乙腈

Others; OCT Membrane transporter/Ion channel; Others
Oct3/4-inducer-1 (2-(4-(4-methoxybenzyloxy)phenyl)acetonitrile) 是Oct3/4诱导剂,能够促进 Oct3/4 的表达和稳定,提高其在多种人体细胞中的转录活性。
T8005 Cardiogenol C hydrochloride

2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐,Cardiogenol C HCl,Cardiogenol C

Wnt/beta-catenin Cytoskeletal Signaling; Stem Cells
Cardiogenol C hydrochloride (Cardiogenol C) 是一种细胞渗透性嘧啶诱导剂,能够促使 ESCs 分化为心肌细胞。在有限的可塑性范围内,它可以对已经沿袭的祖细胞类型产生心肌生成效应,是一种心肌生成试剂,在动物模型中可以用作细胞移植研究中提高心脏修复的工具。
T11571 HLY78

4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine

Wnt/beta-catenin Cytoskeletal Signaling; Stem Cells
HLY78 (4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine) 是 Wnt/β-catenin 信号通路的激活剂,通过靶向通道中 Axin 的 DIX 域,增强 Axin-LRP6 交联,诱导 Wnt 信号转导。
T2161 Cardiogenol C

Wnt/beta-catenin Cytoskeletal Signaling; Stem Cells
Cardiogenol C 是一种细胞渗透性嘧啶诱导剂,能够诱导 ESCs 分化为心肌细胞(EC50:100 nM)。在有限的可塑性范围内,它可以对已经沿袭的祖细胞类型产生心肌病,是一种心肌发生剂。
T7196 HG-10-102-01

[4-[[5-氯-4-(甲基氨基)-2-嘧啶基]氨基]-3-甲氧基苯基]-4-吗啉基甲酮

LRRK2 Autophagy
HG-10-102-01 是富含亮氨酸重复激酶 2 和突变型G2019S 抑制剂,IC50分别为20.3 nM 和3.2 nM。
TP1286 Carcinoembryonic Antigen CEA

癌胚抗原

Others Others
Carcinoembryonic Antigen CEA 是一种广谱性肿瘤标志物,是大肠癌组织产生的一种糖蛋白,作为抗原可引起患者的免疫反应。
T3162 IDE1

Others Others
IDE1 是定形内胚层诱导物,有用于器官移植等方面的潜力。
T15201 MAK683

Histone Methyltransferase Chromatin/Epigenetic
MAK683 是胚胎外胚层发育 (EED) 抑制剂。在 EED Alphascreen 结合、LC-MS 和 ELISA 测定中,IC50值为 59、89 和 26 nM。
T24152 HTH-01-091

HTH-01091,HTH01-091,HTH 01-091,HTH 01091

Serine/threonin kinase; Pim; MELK; DYRK; CDK; RIP kinase Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; Metabolism; NF-κB; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
HTH-01-091 是一种强效且选择性的 maternal embryonic leucine zipper kinase (MELK) 抑制剂(IC50 :10.5 nM)。HTH-01-091 对PIM1/2/3、RIPK2、DYRK3、smMLCK 和 CLK2有抑制作用。HTH-01-091 可用于研究乳腺癌。
T11469 GSK-3484862

DNA Methyltransferase Chromatin/Epigenetic
GSK-3484862 是 有效的 DNA 甲基转移酶 Dnmt1的非共价抑制剂。GSK-3484862 通过诱导 DNA 低甲基化起抗癌作用。GSK-3484862 介导小鼠胚胎干细胞的整体去甲基化。
T6948 Pluripotin

SC1

ERK; Raf; S6 Kinase MAPK; PI3K/Akt/mTOR signaling
Pluripotin (SC1) 是ERK1和RasGAP 的双重抑制剂,KD 分别为 98 和 212 nM。它还抑制RSK1、RSK2、RSK3和RSK4,IC50分别为 0.5、2.5、3.3 和 10.0 μM。
T78170 Kras4B G12D-IN-1

Ras GPCR/G Protein; MAPK
Kras4B G12D-IN-1为Kras4B G12D的抑制剂,表现出抗癌活性。在降低Kras4B G12D表达的小鼠胚胎成纤维细胞(MEF)中减少Kras蛋白水平。
T3458 EED226

Histone Methyltransferase Chromatin/Epigenetic
EED226 是多梳抑制复合物 2 抑制剂,是一种有效的、选择性的、可口服的胚胎外胚层发育 (EED) 抑制剂,IC50 为 22 nM,具有强抗肿瘤活性。当 H3K27me0 肽用作体外酶法测定的底物时,它抑制 PRC2的 IC50为 23.4 nM。
T2019 OAC2

OCT Membrane transporter/Ion channel
OAC2 是一种 Oct4 激活剂,通过 Oct4 基因启动子激活表达, 通过提高胚胎成纤维细胞诱导多能干细胞的产生速率来提高重编程效率,是 OAC1 的类似物。
T22322 EEDi-5285

UM-EEDi-5285,EEDI5285

Histone Methyltransferase Chromatin/Epigenetic
EEDi-5285 是一种非常有效且具有口服活性的胚胎外胚层发育 (EED) 抑制剂,结合 EED 蛋白的 IC50 值为 0.2 nM,并具有抗癌活性。
T2301 SB 202190

FHPI,SB202190

Apoptosis; p38 MAPK; Autophagy Apoptosis; Autophagy; MAPK
SB 202190 (FHPI) 是一种 p38 MAPK 抑制剂,可以抑制 p38α 和 p38β2 (IC50=50/100 nM),具有选择性和细胞渗透性。SB 202190 具有抗肿瘤活性,还可以诱导人胚胎干细胞向心肌细胞分化。
T60143 MitoBloCK-6

Apoptosis Apoptosis
MitoBloCK-6 是一种有效的Erv1/ALR 抑制剂,IC50分别为 900 nM 和 700 nM。MitoBloCK-6 还抑制Erv2,IC50值为1.4 μM。MitoBloCK-6 可通过释放细胞色素 c 诱导 hESCs 细胞凋亡。
T2310 CHIR-99021

Laduviglusib,CT99021,CHIR-99021

GSK-3; Wnt/beta-catenin; Autophagy Autophagy; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Stem Cells
CHIR-99021 (CT99021) 是一种 Wnt/β-catenin 信号通路激活剂,也是一种 GSK-3α/β抑制剂 (IC50=10/6.7 nM),具有选择性和口服活性。CHIR-99021 可以诱导细胞自噬,可增强小鼠和人类胚胎干细胞的自我更新。
T35834L (Sar¹)-Angiotensin II acetate

RAAS Endocrinology/Hormones
(Sar¹)-Angiotensin II acetate 是血管紧张素 II 的类似物,是血管紧张素 AT1 受体的特异性激动剂。它与富含脑膜的颗粒结合,Kd 为 2.7 nM。它可以刺激胚胎鸡肌细胞中的蛋白质合成和细胞生长。
TP1345 Kisspeptin-10, human (TFA)(374675-21-5,FREE)

GPR; Kisspeptin Endocrinology/Hormones; GPCR/G Protein
Kisspeptin-10, human (TFA)(374675-21-5,FREE) 是一种有效的血管收缩剂和血管生成抑制剂。 Kisspeptin-10,人类 TFA 通过其受体 GPR54 充当肿瘤转移抑制因子。 Kisspeptin-10-GPR54系统在胚胎肾发育中发挥重要作用。 Kisspeptin-10/GPR54 信号通过 NFATc4 介导的 BMP2 表达诱导成骨细胞分化
T3637 Pifithrin-β hydrobromide

Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide)

Ferroptosis; p53 Apoptosis
Pifithrin-β hydrobromide (Cyclic PFT-α) 是一种 p53 的抑制剂,可逆地阻断 p53 依赖性转录激活和细胞凋亡。IC50值为23 μM。
T28866 Stemazole

Apoptosis Apoptosis
Stemazole 是一种新型小分子人类干/祖细胞增殖激活剂 ,可促进人类胚胎干细胞的存活并保持干性 ,促进少突胶质细胞前体细胞在体外的存活。Stemazole 能显著提高细胞存活率和克隆形成数,并呈剂量依赖性,降低细胞凋亡率,促进运动功能障碍的恢复和髓鞘的修复。Stemazole 可作为脱髓鞘疾病的治疗剂,促进OPC 体外存活和体内再生。
T36935 PKUMDL-LC-101-D04

GPX4-Activator-1d4,PKUMDL-LC-101-D04

GPX oxidation-reduction
PKUMDL-LC-101-D04是一种高效的谷胱甘肽过氧化物酶4(GPX4)的异位激活剂,是一种铁死亡的调节剂。 当在无细胞试验中使用浓度为20 μM 时,GPX4活性增加到对照水平的150%;在野生型而非Gpx4-/-小鼠胚胎成纤维细胞(MEF)提取物中使用浓度为61 μM 时,GPX4活性增加到对照水平的150%。PKUMDL-LC-101-D04(200 μM)能减少胆固醇过氧化氢诱导的MEF 死亡。
T77697 BML-278

BML278,BML 278

Sirtuin; Histone Methyltransferase Chromatin/Epigenetic; DNA Damage/DNA Repair
BML-278 是一种 SIRT1 激活剂 ,EC150 值为 1 μM。BML-278 增加父本和母本原核中的 H3K9 甲基化并抑制 H3K9 乙酰化,可用于改善早期胚胎发育。BML-278 促使原代人间充质细胞的细胞周期停止在 G1/S 期,可用于延缓衰老。BML-278 减少 U937 细胞中的微管蛋白乙酰化,增加小鼠 C2C12 成肌细胞的线粒体密度。
T2310L CHIR-99021 HCl

CT99021 HCl,Laduviglusib HCl

GSK-3 PI3K/Akt/mTOR signaling; Stem Cells
CHIR-99021 HCl (Laduviglusib HCl) 是GSK-3α/β的高效选择性抑制剂,IC50值分别为10 nM和6.7 nM。它对GSK-3表现出显著的选择性,对CDC2、ERK2和其他蛋白激酶的选择性超过500倍。此外,CHIR-99021 HCl 是Wnt/β-catenin信号通路的强大激活剂。此外,它在小鼠和人类胚胎干细胞中都表现出增强自我更新的能力。此外,拉杜维格西单盐酸盐诱导自噬[1][2][3]。
T70520 TWS-119

Others Others
TWS-119 is an inhibitor of glycogen synthase kinase-3β (GSK-3β) that induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells (ESCs).
T70578 BX-795 hydrochloride

Others Others
BX-795 hydrochloride is a TBK1 and IKKε inhibitor. BX-795 is a potential maternal embryonic leucine zipper kinase inhibitor.
T24129 HBX28258

HBX 28258,HBX-28258

Others Others
HBX28258 is a recombinant human USP7 protein inhibitor. In human colon cancer and embryonic kidney cell, it acts by binding the active site through a covalent mechanism and selectively inactivating USP7 protein.
T84921 CITFA

Others Others
CITFA为一种GPER激动剂,能够促进E18大鼠胚胎海马神经元的神经突生长。
T40154 FTX-6058

Others Others
FTX-6058 is a potent orally active inhibitor targeting Embryonic Ectoderm Development (EED). It effectively induces HbF protein expression in both cell and murine models. This compound holds significant potential for researching select hemoglobinopathies such as sickle cell disease and β-thalassemia.
T35549 Elsinochrome A

Others Others
Elsinochrome A is a perylenequinone fungal metabolite that has been found inHypomycesand has anticancer activity.1Photoactivation of elsinochrome A induces the production of singlet oxygen and apoptosis in R366.4 rhesus monkey embryonic stem cells and HCe-8693 colorectal carcinoma cells when used at concentrations ranging from 1 to 100 μM. 1.Ma, L., Tai, H., Li, C., et al.Photodynamic inhibitory effects of three perylenequinones on human colorectal carcinoma cell line and primate embryonic stem ...
T40155 FTX-6058 hydrochloride

Others Others
FTX-6058 hydrochloride is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED), with the ability to induce HbF protein expression in both cell and murine models. This compound is particularly valuable in the research of select hemoglobinopathies, such as sickle cell disease and β-thalassemia.
T73867 HTH-01-091 TFA

Others Others
HTH-01-091 TFA 是一种强效且选择性的maternal embryonic leucine zipper kinase (MELK)抑制剂,其IC50为 10.5 nM。HTH-01-091 TFA 还能抑制PIM1/2/3、RIPK2、DYRK3、smMLCK 和CLK2。HTH-01-091 TFA 可用于乳腺癌研究。
T69743 MEDS433

Others Others
MEDS433 is a dihydroorotate dehydrogenase inhibitor (IC50 1.2 nM). MEDS433 inhibited the in vitro replication of hCoV-OC43 and hCoV-229E, as well as of SARS-CoV-2, at low nanomolar range. Notably, the anti-SARS-CoV-2 activity of MEDS433 against SARS-CoV-2 was also observed in kidney organoids generated from human embryonic stem cells.
T69195 UC-857993

Others Others
UC-857993 是一种选择性SOS1-Ras 抑制剂 (Kd=14.7 μM, His6-SOS1cat),抑制其催化活性。UC-857993 还能抑制ERK 和Ras 激活,抑制小鼠胚胎成纤维细胞 (MEF) 的生长。
T73945 MAK683-CH2CH2COOH hydrochloride

Others Others
MAK683-CH2CH2COOH 与 EED (胚胎外胚层发育蛋白) 结合。MAK683-CH2CH2COOH 和 E3 泛素连接酶的 VHL 配体设计了 PROTACEED degrader-1 和 PROTACEED degrader-2 。

化合物

EG1
Cat.No: T27246
Synonym:
Target: Others
MELK-8a hydrochloride
Cat.No: T11996
Synonym:
Target: MELK
Pyrintegrin
Cat.No: T16695
Synonym:
Target: Integrin
Epiblastin A
Cat.No: T8987
Synonym:
Target: Casein Kinase
RBC10
Cat.No: T24706
Synonym: RBC 10,RBC-10
Target: GTPase
N-Acetyl-D-cysteine
Cat.No: T38155
Synonym:
Target: Reactive Oxygen Species
MAK-683 hydrochloride
Cat.No: T9681
Synonym:
Target: Histone Methyltransferase
Phthalazinone pyrazole
Cat.No: T21981
Synonym:
Target: Aurora Kinase
OTSSP167
Cat.No: T1759
Synonym: MELK inhibitor,OTS167
Target: MELK
GSK1016790A
Cat.No: T6848
Synonym: GSK101
Target: Calcium Channel, TRP/TRPV Channel
PPQ-102
Cat.No: T1874
Synonym: PPQ102,CFTR Inhibitor,PPQ 102
Target: CFTR, Autophagy
ID-8
Cat.No: T2431
Synonym: ID8
Target: DYRK
MELK-IN-1
Cat.No: T11997
Synonym: Nintedanib Impurity L,MELK inhibitor 17,尼达尼布杂质L
Target: MELK
OTSSP167 hydrochloride
Cat.No: T21559
Synonym: OTSSP 167 盐酸盐
Target: MELK
Oct3/4-inducer-1
Cat.No: T3221
Synonym: 2-(4-(4-methoxybenzyloxy)phenyl)acetonitrile,2-(4-[(4-甲氧基苄基)氧基]苯基)乙腈
Target: Others, OCT
Cardiogenol C hydrochloride
Cat.No: T8005
Synonym: 2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐,Cardiogenol C HCl,Cardiogenol C
Target: Wnt/beta-catenin
HLY78
Cat.No: T11571
Synonym: 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine
Target: Wnt/beta-catenin
Cardiogenol C
Cat.No: T2161
Synonym:
Target: Wnt/beta-catenin
HG-10-102-01
Cat.No: T7196
Synonym: [4-[[5-氯-4-(甲基氨基)-2-嘧啶基]氨基]-3-甲氧基苯基]-4-吗啉基甲酮
Target: LRRK2
Carcinoembryonic Antigen CEA
Cat.No: TP1286
Synonym: 癌胚抗原
Target: Others
IDE1
Cat.No: T3162
Synonym:
Target: Others
MAK683
Cat.No: T15201
Synonym:
Target: Histone Methyltransferase
HTH-01-091
Cat.No: T24152
Synonym: HTH-01091,HTH01-091,HTH 01-091,HTH 01091
Target: Serine/threonin kinase, Pim, MELK, DYRK, CDK, RIP kinase
GSK-3484862
Cat.No: T11469
Synonym:
Target: DNA Methyltransferase
Pluripotin
Cat.No: T6948
Synonym: SC1
Target: ERK, Raf, S6 Kinase
Kras4B G12D-IN-1
Cat.No: T78170
Synonym:
Target: Ras
EED226
Cat.No: T3458
Synonym:
Target: Histone Methyltransferase
OAC2
Cat.No: T2019
Synonym:
Target: OCT
EEDi-5285
Cat.No: T22322
Synonym: UM-EEDi-5285,EEDI5285
Target: Histone Methyltransferase
SB 202190
Cat.No: T2301
Synonym: FHPI,SB202190
Target: Apoptosis, p38 MAPK, Autophagy
MitoBloCK-6
Cat.No: T60143
Synonym:
Target: Apoptosis
CHIR-99021
Cat.No: T2310
Synonym: Laduviglusib,CT99021,CHIR-99021
Target: GSK-3, Wnt/beta-catenin, Autophagy
(Sar¹)-Angiotensin II acetate
Cat.No: T35834L
Synonym:
Target: RAAS
Kisspeptin-10, human (TFA)(374675-21-5,FREE)
Cat.No: TP1345
Synonym:
Target: GPR, Kisspeptin
Pifithrin-β hydrobromide
Cat.No: T3637
Synonym: Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide)
Target: Ferroptosis, p53
Stemazole
Cat.No: T28866
Synonym:
Target: Apoptosis
PKUMDL-LC-101-D04
Cat.No: T36935
Synonym: GPX4-Activator-1d4,PKUMDL-LC-101-D04
Target: GPX
BML-278
Cat.No: T77697
Synonym: BML278,BML 278
Target: Sirtuin, Histone Methyltransferase
CHIR-99021 HCl
Cat.No: T2310L
Synonym: CT99021 HCl,Laduviglusib HCl
Target: GSK-3
TWS-119
Cat.No: T70520
Synonym:
Target: Others
BX-795 hydrochloride
Cat.No: T70578
Synonym:
Target: Others
HBX28258
Cat.No: T24129
Synonym: HBX 28258,HBX-28258
Target: Others
CITFA
Cat.No: T84921
Synonym:
Target: Others
FTX-6058
Cat.No: T40154
Synonym:
Target: Others
Elsinochrome A
Cat.No: T35549
Synonym:
Target: Others
FTX-6058 hydrochloride
Cat.No: T40155
Synonym:
Target: Others
HTH-01-091 TFA
Cat.No: T73867
Synonym:
Target: Others
MEDS433
Cat.No: T69743
Synonym:
Target: Others
UC-857993
Cat.No: T69195
Synonym:
Target: Others
MAK683-CH2CH2COOH hydrochloride
Cat.No: T73945
Synonym:
Target: Others
Cat. No. Product Name Target Signaling Pathways
T19720 Colcemid

C 12669,C-12669,NSC-3096,Kolchicin,C12669,Demecolcine

Microtubule Associated Cytoskeletal Signaling
Colcemid (NSC-3096) 是一种微管聚合抑制剂,可诱导细胞凋亡,可用于肿瘤和胚胎克隆的研究。
T4S1102 Liensinine diperchlorate

莲心碱高氯酸盐,莲心碱二高氯酸盐,Liensinine-Perchlorate

Mitophagy; Others; Autophagy Autophagy; Others
Liensinine Diperchlorate 是从芙蕖种子胚中提取的一种异喹啉生物碱。它通过阻断自噬小体-溶酶体融合来抑制晚期自噬,具有抗心律不齐、抗高血压、抗肺纤维化和血管平滑肌松弛等生物学活性。
T75661 Thymopentin acetate

Others Others
Thymopentin acetate为胸腺皮质及髓质上皮细胞主要分泌的生物活性肽,是一有效免疫调节剂,具有极短的血浆半衰期(30秒),能促进自人类胚胎干细胞生成T细胞群。
T36954 Nemorosone

Others Others
Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 μM).2 It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nem...

天然产物

Colcemid
Cat.No: T19720
Synonym: C 12669,C-12669,NSC-3096,Kolchicin,C12669,Demecolcine
Target: Microtubule Associated
Liensinine diperchlorate
Cat.No: T4S1102
Synonym: 莲心碱高氯酸盐,莲心碱二高氯酸盐,Liensinine-Perchlorate
Target: Mitophagy, Others, Autophagy
Thymopentin acetate
Cat.No: T75661
Synonym:
Target: Others
Nemorosone
Cat.No: T36954
Synonym:
Target: Others
Cat. No. Product Name Species Expression System
TMPY-02379 EED Protein, Human, Recombinant (His & GST)

HEED,WAIT1,embryonic ectoderm development

Human Baculovirus Insect Cells
EED is essential for regulating the repressive histone modification, histone 3 lysine 27 tri-methylation (H3K27me3) at many developmental genes. EED depletion significantly impeded erythroid maturation. EED depletion impaired the generation of hematopoietic stem cells. The function of EED within polycomb repressive complex 2 (PRC2) is mediated by a complex network of protein-protein interactions. The targeted disruption of EED's reader function can lead to allosteric inhibition of PRC2 catalyti...
TMPY-04126 MUSTN1 Protein, Human, Recombinant (His)

musculoskeletal, embryonic nuclear protein 1,MUSTAN...

Human E. coli
MUSTN1 (Musculoskeletal, Embryonic Nuclear Protein 1) is a Protein Coding gene. It may play an important role in regulating musculoskeletal development in mammals. It belongs to the MUSTANG family. The MUSTN1 protein is localized to the nucleus in the myocardium and skeletal muscle fibers. It was expressed the greatest in skeletal muscle. The greatest relative growth rates appeared at the highest expression levels of the MUSTN1 gene, it was thought to play roles in duck muscle development. MUSTN...
TMPH-02301 VPS35 Protein, Human, Recombinant (His & Myc)

VPS35,Vacuolar protein sorting-associated protein 35,Vesicle...

Human E. coli
Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of...
TMPH-01642 MELK Protein, Human, Recombinant (His & Myc)

Protein kinase Eg3,Tyrosine-protein kinase MELK,Protein kina...

Human E. coli
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. ...
TMPH-02023 Renin receptor Protein, Human, Recombinant (His)

Vacuolar ATP synthase membrane sector-associated protein M8-...

Human E. coli
Renin receptor Protein, Human, Recombinant (His) is expressed in E. coli.
TMPY-03104 FGF-17 Protein, Human, Recombinant

fibroblast growth factor 17,HH20,FGF-13,FGF-17

Human E. coli
FGF-13, also known as FGF17, belongs to the fibroblast growth factor (FGF) family. Members of this family show broad mitogenic and cell survival activities, and play a role in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-13 is preferentially expressed in the embryonic brain. It interacts with FGFR3 and FGFR4. FGF-13 plays an important role in the regulation of embryonic development and as signaling mol...
TMPJ-00090 FGF-9 Protein, Human, Recombinant

Fibroblast Growth Factor 9,Heparin-Binding Growth Factor 9,F...

Human E. coli
Fibroblast Growth Factor 9 (FGF-9) belongs to the Fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-9 plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. In addition, FGF-9 may have a role in glial c...
TMPY-01061 FGF-10 Protein, Human, Recombinant

fibroblast growth factor 10,KGF2

Human E. coli
Fibroblast growth factor 10 (FGF10) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF10 exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. FGF10 pla...
TMPY-03382 FGF-6 Protein, Human, Recombinant

HBGF-6,HST2,fibroblast growth factor 6

Human E. coli
FGF6, also known as FGF-6, belongs to the fibroblast growth factor (FGF) family. Members of this family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF6 plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis. It is also required for normal muscle regeneration. FGF6 gene d...
TMPJ-00842 FGF-2 Protein, Rat, Recombinant

bFGF,Heparin-Binding Growth Factor 2,FGFB,Fibroblast Growth ...

Rat E. coli
FGF-basic is a members of the Fibroblast Growth Factors (FGFs) family. The family constitutes a large family of proteins involved in many aspects of development including cell proliferation, growth, and differentiation. They act on several cell types to regulate diverse physiologic functions including angiogenesis, cell growth, pattern formation, embryonic development, metabolic regulation, cell migration, neurotrophic effects, and tissue repair. FGF-basic is a non-glycosylated heparin binding g...
TMPJ-00258 TGF beta 2 Protein, Human, Recombinant

Glioblastoma-derived T-cell suppressor factor,TGF-β-2,Transf...

Human HEK293 Cells
Transforming growth factor beta-2 (TGF-β2) is a secreted protein which belongs to the TGF-beta family. It is known as a cytokine that performs many cellular functions and has a vital role during embryonic development. The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive. It is an extracellular glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumors. Defects in TGFB2 may be...
TMPJ-01471 Activin A Protein, Human, Mouse, Rat, Cynomolgus, Rhesus, Recombinant

Activin A,INHBA,Inhibin beta A chain,Inhibin β A chain

Human/Mouse/Rat HEK293 Cells
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell developm...
TMPJ-00562 PDGF-BB Protein, Mouse, Recombinant (His)

PDGFBB,PDGF-BB,血小板源生长因子

Mouse E. coli
Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. As growth factor,it plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival...
TMPY-02907 FGF-19 Protein, Human, Recombinant

fibroblast growth factor 19,FGF19

Human E. coli
FGF19, also known as FGF-19, is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF19 interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL, KLB and heparan sulfate glycosaminoglyca...
TMPY-05004 FGF-4 Protein, Human, Recombinant

HST-1,KFGF,fibroblast growth factor 4,HSTF1,K-FGF,HST,HBGF-4

Human E. coli
FGF (fibroblast growth factor) signalling is known to be required for many aspects of mesoderm formation and patterning during Xenopus development and has been implicated in regulating genes required for the specification of both blood and skeletal muscle lineages. Fibroblast growth factor 4 (FGF4) signaling induces differentiation from embryonic stem cells (ESCs) via the phosphorylation of downstream molecules such as mitogen-activated protein kinase/extracellular signal-related kinase (MEK) a...
TMPJ-00037 FGF-2 Protein, Mouse, Recombinant

Fibroblast Growth Factor 2,bFGF,HBGF-2,Basic Fibroblast Grow...

Mouse E. coli
FGF basic is one of 22 mitogenic proteins of the FGF family, which show 35-60% amino acid conservation. Unlike other FGFs, FGF acidic and basic lack signal peptides and are secreted by an alternate pathway. The 17 kDa mouse sequence has 98% aa identity with rat, and 95% identity with human, bovine, and sheep FGF basic. Binding of FGF to heparin or cell surface HSPG is necessary for binding, dimerization and activation of tyrosine kinase FGF receptors. FGF basic binds other proteins, polysacchari...
TMPJ-01065 Noggin/NOG Protein, Mouse, Recombinant (His)

Nog,Noggin

Mouse HEK293 Cells
Noggin is a secreted homodimeric glycoprotein that is an antagonist of bone morphogenetic proteins (BMPs). Mouse Noggin cDNA encodes a 232 amino acid (aa) residue precursor protein with 19 aa residue putative signal peptide that is cleaved to generate the 213 aa residue mature protein which is secreted as a homodimeric glycoprotein. Secreted Noggin probably remains close to the cell surface due to its binding of heparin-containing proteoglycans. Noggin binds some BMPs such as BMP4 with high affi...
TMPJ-01011 FGF-9 Protein, Mouse, Recombinant (His)

heparin-binding growth factor-9,GAF,HBGF-9,Glia-activating f...

Mouse E. coli
Fibroblast growth factor-9 (FGF-9) is an approximately 26 kDa secreted glycoprotein of the FGF family. Secreted mouse FGF-9 lacks the N-terminal 1-3 aa and shares >98% sequence identity with rat, human, equine, porcine and bovine FGF-9. FGF-9 plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. In the mouse embryo the location and timing of FGF-9 expression affects development of the skeleton, cerebellum, lungs, heart, v...
TMPJ-00412 VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)

Vascular endothelial growth factor receptor 1,Vascular perme...

Human HEK293 Cells
Human Vascular endothelial growth factor receptor 1(VEGFR-1, FLT-1) is a member of the the class III subfamily of receptor tyrosine kinases (RTKs) and Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 is widely expressed in human tissues including normal lung, placenta, liver, kidney, heart and brain tissues. It is specifically expressed in most of the vascular endothelial cellsand peripheral blood monocytes. VEGFR-1 contains seven Ig-like C2-type domains and one protein kinas...
TMPJ-00096 FGF-17 Protein, Human, Recombinant (His)

Fibroblast Growth Factor 17,FGF17,FGF-17

Human HEK293 Cells
Fibroblast Growth Factor 17 (FGF17) is a member of the heparin-binding growth factors family that is prominently expressed in the cerebellum and cortex. Proteins of this family possess broad mitogenic and cell survival activities and they are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth, and invasion. FGF17 plays an important role in the regulation of embryonic development and it acts as signaling molecule i...
TMPH-01895 POU5F1 Protein, Human, Recombinant (B2M & His)

Octamer-binding protein 4,Octamer-binding protein 3,POU5F1,O...

Human E. coli
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. POU5F1 Protein, Human, Recombinant (B2M & His) is expressed in E. coli expression system with N-6xHis-B2M tag. The predicted molecular weight is 52.6 kDa and the accession number is Q...
TMPH-02858 Wnt2 Protein, Mouse, Recombinant (His)

Protein Wnt-2,INT-1-related protein,Wnt2

Mouse E. coli
Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons.
TMPH-01602 LAMA5 Protein, Human, Recombinant (His & SUMO)

LAMA5,Laminin subunit alpha-5,Laminin-15 subunit alpha,Lamin...

Human E. coli
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
TMPJ-00677 TGOLN2 Protein, Human, Recombinant (His)

Trans-Golgi network protein TGN51,TGN38 homolog,TGN51,TGN46,...

Human HEK293 Cells
This protein may be involved in regulating membrane traffic to and from trans-Golgi network. Isoform TGN46 is widely expressed. Isoform TGN51 is more abundant in fetal lung and kidney. Isoform TGN48 is barely expressed in embryonic kidney and promyelocytic cells.
TMPH-03321 KRTDAP Protein, Rat, Recombinant (His & SUMO)

Keratinocyte differentiation-associated protein,Krtdap

Rat E. coli
May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis. KRTDAP Protein, Rat, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 21.5 kDa and the accession number is P85411.
TMPH-01355 FXR1 Protein, Human, Recombinant (His)

FXR1,RNA-binding protein FXR1,FMR1 autosomal homolog 1,hFXR1...

Human E. coli
RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs. FXR1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 70.5 kDa and the accession number is P51114.
TMPJ-00835 FGF-4 Protein, Mouse, Recombinant

HSTF1,HST-1,FGF4,FGF-4,HBGF-4,Fibroblast growth factor 4,HST...

Mouse E. coli
Fibroblast growth factor 4(FGF-4) is a heparin binding member of the FGF family. The human FGF4 cDNA encodes 206 amino acids (aa) with a 33 aa signal sequence and a 173 aa mature protein with an FGF homology domain that contains a heparin binding region near the C-terminus. Mature human FGF4 shares 91%, 82%, 94% and 91% aa identity with mouse, rat, canine and bovine FGF4, respectively. Human FGF-4 has been shown to exhibit cross species activity. Expression of FGF-4 and its receptors, FGF R1c, 2...
TMPK-00868 Notch 4 Protein, Mouse, Recombinant (His)

Notch-4,Int-3,Notch4,Int3

Mouse HEK293 Cells
The Notch signaling pathway is important for cell-cell communication; it is involved in gene regulation mechanisms that control multiple cell differentiation processes during embryonic and adult life. Notch-4 expression correlates with Ki67. Notch-4 also plays a key role in breast cancer stem-like cells.
TMPH-02293 UGDH Protein, Human, Recombinant (His & SUMO)

UDP-glucose 6-dehydrogenase,UGDH

Human E. coli
Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans. Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans. Required for proper brain and neuronal development.
TMPH-00068 Vitellogenin Protein, Apis mellifera, Recombinant (His)

Vitellogenin,Vg

Apis mellifera E. coli
Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development. Involved in the differentiation of honeybee larvae into queens. Vitellogenin Protein, Apis mellifera, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 32.5 kDa and the accession number is Q868N5.
TMPH-02865 Wnt3 Protein, Mouse, Recombinant (His & SUMO)

Proto-oncogene Int-4,Proto-oncogene Wnt-3,Wnt3

Mouse E. coli
Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge and for normal embryonic limb development.
TMPJ-01300 PDCD10 Protein, Human, Recombinant

TFAR15,Programmed Cell Death Protein 10,PDCD10,TF-1 Cell Apo...

Human E. coli
Programmed Cell Death Protein 10 (PDCD10) belongs to the PDCD10 family. PDCD10 exists as a homodimer and is widely expressed. PDCD10 can increase mitogen-activated protein kinase activity and MST4 activity. PDCD10 is required for normal cardiovascular development and normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development. Defects in PDCD10 are the cause of cerebral cavernous malformations type 3.
TMPK-01186 B7-H5/Gi24/VISTA Protein, Human, Recombinant (His)

VSIR,B7H5,4632428N05Rik,SISP1,PP2135,Dies1,PD-1H,VISTA,C10or...

Human HEK293 Cells
B7-H5, also known as VISTA , B7H5, Dies1, SISP1 and C10orf54, is a 55-65 kDa member of the Ig superfamily. It is a transmembrane molecule expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. B7-H5/Gi24/VISTA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 19 kDa and the accession number is Q9H7M9.
TMPJ-00879 HOXB4 Protein, Human,Recombinant (L175D, E176K, E178K, His)

Homeobox protein Hox-2.6,HOX2F,HOXB4,Homeobox protein Hox-2F...

Human E. coli
Homeobox B4 (HOXB4) is encoded by the HOXB4 gene which is a member of the the class I homeobox (HOX) gene family and encodes a nuclear protein with a homeobox DNA-binding domain. These genes are master control regulators of developmental programs including embryonic and adult hematopoiesis. Multiple HOX genes, including HOXB4, are highly expressed in the hematopoietic stem cells (HSC) compartment. HOXB4 gene can act in opposite ways when expressed by different cells, promoting the proliferation ...
TMPK-01185 B7-H5/Gi24/VISTA Protein, Human, Recombinant (hFc)

PP2135,SISP1,VISTA,Gi24,B7H5,4632428N05Rik,Dies1,PD1H,VSIR,B...

Human HEK293 Cells
B7-H5, also known as VISTA , B7H5, Dies1, SISP1 and C10orf54, is a 55-65 kDa member of the Ig superfamily. It is a transmembrane molecule expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. B7-H5/Gi24/VISTA Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 44.9 kDa and the accession number is Q9H7M9.
TMPK-00233 CEACAM6 Protein, Human, Recombinant (aa 35-320, His & Avi), Biotinylated

NCA,CEACAM6,CEA,CD66c,CEAL

Human HEK293 Cells
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) belongs to the human carcino-embryonic antigen (CEA) family. Numerous lines of studies have indicated that altered expression of CEACAM6 may have a role in carcinogenesis and development. CEACAM6 Protein, Human, Recombinant (aa 35-320, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 34.1 kDa and the accession number is P40199.
TMPK-00232 CEACAM6 Protein, Human, Recombinant (His & Avi)

CEA,CD66c,CEAL,CEACAM6,NCA

Human HEK293 Cells
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) belongs to the human carcino-embryonic antigen (CEA) family. Numerous lines of studies have indicated that altered expression of CEACAM6 may have a role in carcinogenesis and development. CEACAM6 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 34.1 kDa and the accession number is P40199.
TMPK-01311 CEACAM6 Protein, Cynomolgus, Recombinant (aa 35-320, His)

CEACAM6,CEAL,CEA,NCA,CD66c

Cynomolgus HEK293 Cells
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) belongs to the human carcino-embryonic antigen (CEA) family. Numerous lines of studies have indicated that altered expression of CEACAM6 may have a role in carcinogenesis and development. CEACAM6 Protein, Cynomolgus, Recombinant (aa 35-320, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 32.73 kDa and the accession number is XP_014979566.2.
TMPY-04003 UNC5B Protein, Rat, Recombinant (hFc)

unc-5 homolog B (C. elegans)

Rat HEK293 Cells
The netrin-1 receptor, UNC-5 Homology B, or UNC5B plays vital roles in angiogenesis, inflammation, embryonic development and carcinogenesis. Overexpression of UNC5B human colon epithelial cells suppressed dextran sodium sulfate, or DSS-induced apoptosis and caspase-3 activity. Besides, is a potential anti-neoplastic target in bladder cancer progression and inflammatory arthritis. UNC5B Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular we...
TMPY-04828 TFF3 Protein, Human, Recombinant (His)

trefoil factor 3 (intestinal),ITF,P1B,TFI

Human HEK293 Cells
Trefoil factor family (TFF) peptides are involved in the maintenance of epithelial integrity and epithelial restitution. Trefoil factor-3 (TFF3) is an estrogen-regulated gene associated with prognosis in different types of cancer. The presence and localization of TFF3 peptide was associated with the embryonic stage and tissue differentiation. TFF3 peptide distribution specific to the germ layers was not observed. The role of TFF3 peptide in cell migration and differentiation, immune response, an...
TMPK-00453 HER3/ERBB3 Protein, Human, Recombinant (His & Avi)

p45-sErbB3,MDA-BF-1,ErbB-3,HER3c-erbB-3,ErbB3,MGC88033,LCCS2...

Human HEK293 Cells
Her3, also called ErbB3, is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors.Her3 is expressed in keratinocytes, melanocytes, skeletal muscle cells, embryonic myoblasts and Schwann cells. Monomeric Her3 serves as a low affinity receptor for the heregulins (HRG). HER3/ERBB3 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 71.6 kDa and the accession number is P21860-1.
TMPK-00452 HER3/ERBB3 Protein, Human, Recombinant (His & Avi), FITC-Labeled

LCCS2,HER3c-erbB-3,p180-ErbB3,MGC88033,ErbB3,p85-sErbB3,p45-...

Human HEK293 Cells
Her3, also called ErbB3, is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors.Her3 is expressed in keratinocytes, melanocytes, skeletal muscle cells, embryonic myoblasts and Schwann cells. Monomeric Her3 serves as a low affinity receptor for the heregulins (HRG). HER3/ERBB3 Protein, Human, Recombinant (His & Avi), FITC-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 71.6 kDa and the accession numbe...
TMPK-01280 HER3/ERBB3 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)

p85-sErbB3,HER3,LCCS2,p180-ErbB3,HER3c-erbB-3,ErbB-3,ERBB3,M...

Cynomolgus,Rhesus HEK293 Cells
Her3, also called ErbB3, is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors.Her3 is expressed in keratinocytes, melanocytes, skeletal muscle cells, embryonic myoblasts and Schwann cells. Monomeric Her3 serves as a low affinity receptor for the heregulins (HRG). HER3/ERBB3 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 69.54 kDa and the accession number i...
TMPJ-00752 HBAZ Protein, Human, Recombinant (His)

Hemoglobin Subunit Zeta,Hemoglobin ζ Chain,Hemoglobin Zeta C...

Human E. coli
Hemoglobin Subunit Zeta (HBZ) is a member of the Globin family. The zeta chain is an alpha-type chain of mammalian embryonic Hemoglobin that is synthesized primarily in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal growth and adult life. The HBZ gene consists of five functional genes and two pseudogenes, the order of genes is 5-zeta-pseudozeta-mu-pseudoalpha-1-alpha-2-alpha-1-theta-1-3.
TMPJ-00692 GAS7 Protein, Human, Recombinant (His)

GAS-7,GAS7,Growth Arrest-Specific Protein 7,KIAA0394

Human E. coli
Growth Arrest-Specific Protein 7 (GAS7) is expressed primarily in terminalaly differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 may play a role in neuronal development by promoting maturation and morphological differentiation of cerebellar neurons. Inhibition of GAS7 production in terminally differentiating cultures of embryonic murine cerebullum impedes neurite outgrowth. The hyper-expression of GAS7 may play an major role in the initiation and development...
TMPH-02864 Wnt1 Protein, Mouse, Recombinant (His & Myc)

Proto-oncogene Wnt-1,Wnt1,Proto-oncogene Int-1

Mouse E. coli
Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Plays an essential role in the development of the embryonic brain and central nervous system (CNS). Has a role in osteoblast function, bone development and bone homeostasis.
TMPK-00520 PTK7/CCK4 Protein, Cynomolgus, Recombinant (His)

PTK7,CCK-4

Cynomolgus HEK293 Cells
Protein Tyrosine Kinase 7 (PTK7) is as a critical regulator of canonical and non-canonical Wnt-signaling during embryonic development and cancer cell formation. Disrupting PTK7 activity perturbs vertebrate nervous system development, and also promotes human cancer formation. Observations in different model systems suggest a complex cross-talk between PTK7 protein and Wnt signaling. PTK7/CCK4 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predict...
TMPY-00507 UNC5B Protein, Human, Recombinant (hFc)

unc-5 homolog B (C. elegans),UNC5H2,p53RDL1

Human HEK293 Cells
The netrin-1 receptor, UNC-5 Homology B, or UNC5B plays vital roles in angiogenesis, inflammation, embryonic development and carcinogenesis. Overexpression of UNC5B human colon epithelial cells suppressed dextran sodium sulfate, or DSS-induced apoptosis and caspase-3 activity. Besides, is a potential anti-neoplastic target in bladder cancer progression and inflammatory arthritis. UNC5B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular ...
TMPY-04133 UNC5B Protein, Human, Recombinant (His)

UNC5H2,p53RDL1,unc-5 homolog B (C. elegans)

Human HEK293 Cells
The netrin-1 receptor, UNC-5 Homology B, or UNC5B plays vital roles in angiogenesis, inflammation, embryonic development and carcinogenesis. Overexpression of UNC5B human colon epithelial cells suppressed dextran sodium sulfate, or DSS-induced apoptosis and caspase-3 activity. Besides, is a potential anti-neoplastic target in bladder cancer progression and inflammatory arthritis. UNC5B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular ...
TMPK-01093 Kremen-2 Protein, Mouse, Recombinant (His)

KRM2,KREMEN2,Dickkopf receptor 2,Kremen-2

Mouse HEK293 Cells
Kremen2 (Krm2) plays an important role in embryonic development, bone formation, and tumorigenesis as a crucial regulator of classical Wnt/β-catenin signaling pathway. Compared to para-cancerous tissues, Krm2 was significantly up-regulated in gastric cancer tissues and was positively correlated with the pathological grade of gastric cancer patients. Krm2 can be a potent candidate for designing of targeted therapy. Kremen-2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells ...
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重组蛋白

EED Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-02379
Species: Human
Expression System: Baculovirus Insect Cells
MUSTN1 Protein, Human, Recombinant (His)
Cat.No: TMPY-04126
Species: Human
Expression System: E. coli
VPS35 Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-02301
Species: Human
Expression System: E. coli
MELK Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01642
Species: Human
Expression System: E. coli
Renin receptor Protein, Human, Recombinant (His)
Cat.No: TMPH-02023
Species: Human
Expression System: E. coli
FGF-17 Protein, Human, Recombinant
Cat.No: TMPY-03104
Species: Human
Expression System: E. coli
FGF-9 Protein, Human, Recombinant
Cat.No: TMPJ-00090
Species: Human
Expression System: E. coli
FGF-10 Protein, Human, Recombinant
Cat.No: TMPY-01061
Species: Human
Expression System: E. coli
FGF-6 Protein, Human, Recombinant
Cat.No: TMPY-03382
Species: Human
Expression System: E. coli
FGF-2 Protein, Rat, Recombinant
Cat.No: TMPJ-00842
Species: Rat
Expression System: E. coli
TGF beta 2 Protein, Human, Recombinant
Cat.No: TMPJ-00258
Species: Human
Expression System: HEK293 Cells
Activin A Protein, Human, Mouse, Rat, Cynomolgus, Rhesus, Recombinant
Cat.No: TMPJ-01471
Species: Human/Mouse/Rat
Expression System: HEK293 Cells
PDGF-BB Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-00562
Species: Mouse
Expression System: E. coli
FGF-19 Protein, Human, Recombinant
Cat.No: TMPY-02907
Species: Human
Expression System: E. coli
FGF-4 Protein, Human, Recombinant
Cat.No: TMPY-05004
Species: Human
Expression System: E. coli
FGF-2 Protein, Mouse, Recombinant
Cat.No: TMPJ-00037
Species: Mouse
Expression System: E. coli
Noggin/NOG Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-01065
Species: Mouse
Expression System: HEK293 Cells
FGF-9 Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-01011
Species: Mouse
Expression System: E. coli
VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)
Cat.No: TMPJ-00412
Species: Human
Expression System: HEK293 Cells
FGF-17 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00096
Species: Human
Expression System: HEK293 Cells
POU5F1 Protein, Human, Recombinant (B2M & His)
Cat.No: TMPH-01895
Species: Human
Expression System: E. coli
Wnt2 Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02858
Species: Mouse
Expression System: E. coli
LAMA5 Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-01602
Species: Human
Expression System: E. coli
TGOLN2 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00677
Species: Human
Expression System: HEK293 Cells
KRTDAP Protein, Rat, Recombinant (His & SUMO)
Cat.No: TMPH-03321
Species: Rat
Expression System: E. coli
FXR1 Protein, Human, Recombinant (His)
Cat.No: TMPH-01355
Species: Human
Expression System: E. coli
FGF-4 Protein, Mouse, Recombinant
Cat.No: TMPJ-00835
Species: Mouse
Expression System: E. coli
Notch 4 Protein, Mouse, Recombinant (His)
Cat.No: TMPK-00868
Species: Mouse
Expression System: HEK293 Cells
UGDH Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-02293
Species: Human
Expression System: E. coli
Vitellogenin Protein, Apis mellifera, Recombinant (His)
Cat.No: TMPH-00068
Species: Apis mellifera
Expression System: E. coli
Wnt3 Protein, Mouse, Recombinant (His & SUMO)
Cat.No: TMPH-02865
Species: Mouse
Expression System: E. coli
PDCD10 Protein, Human, Recombinant
Cat.No: TMPJ-01300
Species: Human
Expression System: E. coli
B7-H5/Gi24/VISTA Protein, Human, Recombinant (His)
Cat.No: TMPK-01186
Species: Human
Expression System: HEK293 Cells
HOXB4 Protein, Human,Recombinant (L175D, E176K, E178K, His)
Cat.No: TMPJ-00879
Species: Human
Expression System: E. coli
B7-H5/Gi24/VISTA Protein, Human, Recombinant (hFc)
Cat.No: TMPK-01185
Species: Human
Expression System: HEK293 Cells
CEACAM6 Protein, Human, Recombinant (aa 35-320, His & Avi), Biotinylated
Cat.No: TMPK-00233
Species: Human
Expression System: HEK293 Cells
CEACAM6 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00232
Species: Human
Expression System: HEK293 Cells
CEACAM6 Protein, Cynomolgus, Recombinant (aa 35-320, His)
Cat.No: TMPK-01311
Species: Cynomolgus
Expression System: HEK293 Cells
UNC5B Protein, Rat, Recombinant (hFc)
Cat.No: TMPY-04003
Species: Rat
Expression System: HEK293 Cells
TFF3 Protein, Human, Recombinant (His)
Cat.No: TMPY-04828
Species: Human
Expression System: HEK293 Cells
HER3/ERBB3 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00453
Species: Human
Expression System: HEK293 Cells
HER3/ERBB3 Protein, Human, Recombinant (His & Avi), FITC-Labeled
Cat.No: TMPK-00452
Species: Human
Expression System: HEK293 Cells
HER3/ERBB3 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)
Cat.No: TMPK-01280
Species: Cynomolgus,Rhesus
Expression System: HEK293 Cells
HBAZ Protein, Human, Recombinant (His)
Cat.No: TMPJ-00752
Species: Human
Expression System: E. coli
GAS7 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00692
Species: Human
Expression System: E. coli
Wnt1 Protein, Mouse, Recombinant (His & Myc)
Cat.No: TMPH-02864
Species: Mouse
Expression System: E. coli
PTK7/CCK4 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-00520
Species: Cynomolgus
Expression System: HEK293 Cells
UNC5B Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00507
Species: Human
Expression System: HEK293 Cells
UNC5B Protein, Human, Recombinant (His)
Cat.No: TMPY-04133
Species: Human
Expression System: HEK293 Cells
Kremen-2 Protein, Mouse, Recombinant (His)
Cat.No: TMPK-01093
Species: Mouse
Expression System: HEK293 Cells
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