79
4
4
126
Cat. No. | Product Name | ||
---|---|---|---|
L4300 | Wnt/Hedgehog/Notch 通路化合物库 | 237 compounds | |
237 个Wnt & Hedgehog & Notch 靶点相关的生物活性小分子化合物的特有集合,用于相关通路的研究及药物的筛选,可用于高通量、高内涵筛选。 | |||
L1380 | 转录因子库 | 695 compounds | |
695 种转录因子靶向、结构新颖的化合物; | |||
L4100 | TGF-β/Smad靶点化合物库 | 184 compounds | |
184 个 TGF-β/Smad 靶点相关的小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L8000 | 干细胞分化化合物库 | 1197 compounds | |
1197 种干细胞分化信号通路相关的生物活性小分子化合物的特有集合,可用于高通量、高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T27246 |
EG1
|
Others | Others |
EG1 是特异性 Pax2<.b> 抑制剂,能够直接结合 Pax2 的配对结构域 (Kd:1.35-1.5 μM) ,可阻碍 Pax2-DNA 相互作用。它能够抑制胚胎肾脏发育,此过程直接依赖于 Pax2活性。 | |||
T11996 |
MELK-8a hydrochloride
|
MELK | PI3K/Akt/mTOR signaling |
MELK-8a hydrochloride 是一种有效的母体胚胎亮氨酸拉链激酶抑制剂,IC50 为 2 nM。 | |||
T16695 |
Pyrintegrin
|
Integrin | Cytoskeletal Signaling |
Pyrintegrin 是一种 β1 整合素激动剂,也是 2,4-二取代的嘧啶,可促进胚胎干细胞存活。它可用作足细胞保护剂,能增强细胞-细胞外基质 (ECM) 粘附介导的整联蛋白信号传导,具有强大的成脂作用。 | |||
T8987 |
Epiblastin A
|
Casein Kinase | Metabolism; Stem Cells |
Epiblastin A 是 ATP 竞争性的酪蛋白激酶 1 (CK1) 抑制剂,能够抑制 CK1α (IC50:8.9 µM)、 CK1δ (IC50:0.5 µM)、CK1 ɛ (IC50:4.7 µM)。它能够抑制 CK1 诱导外胚层干细胞重编程为胚胎干细胞。 | |||
T24706 |
RBC10
RBC 10,RBC-10 |
GTPase | GPCR/G Protein |
RBC10 抑制 Ral 与其效应物 RALBP1 的结合,以及抑制 Ral 介导的鼠胚胎成纤维细胞的细胞扩散和人类癌细胞系的非贴壁依赖性生长。 | |||
T38155 |
N-Acetyl-D-cysteine
|
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
N-Acetyl-D-cysteine 具有抗氧化活性,机制是通过与巯基反应清除ROS。N-Acetyl-D-cysteine 不能进入谷胱甘肽代谢途径。 | |||
T9681 |
MAK-683 hydrochloride
|
Histone Methyltransferase | Chromatin/Epigenetic |
MAK683 hydrochloride 是胚胎外胚层发育 (EED) 抑制剂。MAK683 hydrochloride 在 EED Alphascreen, ELISA 和 LC-MS 试验中测得的IC50 值分别为 59,26,89 nM。 | |||
T21981 |
Phthalazinone pyrazole
|
Aurora Kinase | Cell Cycle/Checkpoint; Chromatin/Epigenetic |
Phthalazinone pyrazole 是强效、选择性和口服生物可利用的 Aurora-A 激酶抑制剂,IC50值为 0.031 μM。它抑制人胚胎干细胞向肝细胞样细胞分化过程中的上皮间质转化。它还可阻止有丝分裂并随后通过增殖细胞的凋亡抑制肿瘤生长。 | |||
T1759 |
OTSSP167
MELK inhibitor,OTS167 |
MELK | PI3K/Akt/mTOR signaling |
OTSSP167 (OTS167) 是一种高效的,ATP 竞争性的 MELK 抑制剂,其 IC50=0.41 nM。 | |||
T6848 |
GSK1016790A
GSK101 |
Calcium Channel; TRP/TRPV Channel | Membrane transporter/Ion channel; Metabolism |
GSK1016790A (GSK101) 是选择性瞬时受体电位香草酸 4 通道激活剂,可引起 HEK 细胞中 Ca2+流入并升高细胞内 Ca2+。 | |||
T1874 |
PPQ-102
PPQ102,CFTR Inhibitor,PPQ 102 |
CFTR; Autophagy | Autophagy; Membrane transporter/Ion channel |
PPQ-102 (CFTR Inhibitor) 是一种CFTR 抑制剂,可以完全抑制CFTR 氯化物电流,IC50为90 nM。 | |||
T2431 |
ID-8
ID8 |
DYRK | Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors |
ID-8 是 DYRK 抑制剂,长时间培养能够维持胚胎干细胞的自我更新。 | |||
T11997 |
MELK-IN-1
Nintedanib Impurity L,MELK inhibitor 17,尼达尼布杂质L |
MELK | PI3K/Akt/mTOR signaling |
MELK-IN-1 (MELK inhibitor 17)是一种母体胚胎亮氨酸拉链激酶的有效抑制剂,IC50=3 nM,Ki=0.39 nM。 | |||
T21559 |
OTSSP167 hydrochloride
OTSSP 167 盐酸盐 |
MELK | PI3K/Akt/mTOR signaling |
OTSSP167 hydrochloride 是一种高效的,ATP 竞争性的MELK 抑制剂,其 IC50=0.41 nM。 | |||
T3221 |
Oct3/4-inducer-1
2-(4-(4-methoxybenzyloxy)phenyl)acetonitrile,2-(4-[(4-甲氧基苄基)氧基]苯基)乙腈 |
Others; OCT | Membrane transporter/Ion channel; Others |
Oct3/4-inducer-1 (2-(4-(4-methoxybenzyloxy)phenyl)acetonitrile) 是Oct3/4诱导剂,能够促进 Oct3/4 的表达和稳定,提高其在多种人体细胞中的转录活性。 | |||
T8005 |
Cardiogenol C hydrochloride
2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐,Cardiogenol C HCl,Cardiogenol C |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Cardiogenol C hydrochloride (Cardiogenol C) 是一种细胞渗透性嘧啶诱导剂,能够促使 ESCs 分化为心肌细胞。在有限的可塑性范围内,它可以对已经沿袭的祖细胞类型产生心肌生成效应,是一种心肌生成试剂,在动物模型中可以用作细胞移植研究中提高心脏修复的工具。 | |||
T11571 |
HLY78
4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
HLY78 (4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine) 是 Wnt/β-catenin 信号通路的激活剂,通过靶向通道中 Axin 的 DIX 域,增强 Axin-LRP6 交联,诱导 Wnt 信号转导。 | |||
T2161 |
Cardiogenol C
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Cardiogenol C 是一种细胞渗透性嘧啶诱导剂,能够诱导 ESCs 分化为心肌细胞(EC50:100 nM)。在有限的可塑性范围内,它可以对已经沿袭的祖细胞类型产生心肌病,是一种心肌发生剂。 | |||
T7196 |
HG-10-102-01
[4-[[5-氯-4-(甲基氨基)-2-嘧啶基]氨基]-3-甲氧基苯基]-4-吗啉基甲酮 |
LRRK2 | Autophagy |
HG-10-102-01 是富含亮氨酸重复激酶 2 和突变型G2019S 抑制剂,IC50分别为20.3 nM 和3.2 nM。 | |||
TP1286 |
Carcinoembryonic Antigen CEA
癌胚抗原 |
Others | Others |
Carcinoembryonic Antigen CEA 是一种广谱性肿瘤标志物,是大肠癌组织产生的一种糖蛋白,作为抗原可引起患者的免疫反应。 | |||
T3162 |
IDE1
|
Others | Others |
IDE1 是定形内胚层诱导物,有用于器官移植等方面的潜力。 | |||
T15201 |
MAK683
|
Histone Methyltransferase | Chromatin/Epigenetic |
MAK683 是胚胎外胚层发育 (EED) 抑制剂。在 EED Alphascreen 结合、LC-MS 和 ELISA 测定中,IC50值为 59、89 和 26 nM。 | |||
T24152 |
HTH-01-091
HTH-01091,HTH01-091,HTH 01-091,HTH 01091 |
Serine/threonin kinase; Pim; MELK; DYRK; CDK; RIP kinase | Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; Metabolism; NF-κB; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
HTH-01-091 是一种强效且选择性的 maternal embryonic leucine zipper kinase (MELK) 抑制剂(IC50 :10.5 nM)。HTH-01-091 对PIM1/2/3、RIPK2、DYRK3、smMLCK 和 CLK2有抑制作用。HTH-01-091 可用于研究乳腺癌。 | |||
T11469 |
GSK-3484862
|
DNA Methyltransferase | Chromatin/Epigenetic |
GSK-3484862 是 有效的 DNA 甲基转移酶 Dnmt1的非共价抑制剂。GSK-3484862 通过诱导 DNA 低甲基化起抗癌作用。GSK-3484862 介导小鼠胚胎干细胞的整体去甲基化。 | |||
T6948 |
Pluripotin
SC1 |
ERK; Raf; S6 Kinase | MAPK; PI3K/Akt/mTOR signaling |
Pluripotin (SC1) 是ERK1和RasGAP 的双重抑制剂,KD 分别为 98 和 212 nM。它还抑制RSK1、RSK2、RSK3和RSK4,IC50分别为 0.5、2.5、3.3 和 10.0 μM。 | |||
T78170 |
Kras4B G12D-IN-1
|
Ras | GPCR/G Protein; MAPK |
Kras4B G12D-IN-1为Kras4B G12D的抑制剂,表现出抗癌活性。在降低Kras4B G12D表达的小鼠胚胎成纤维细胞(MEF)中减少Kras蛋白水平。 | |||
T3458 |
EED226
|
Histone Methyltransferase | Chromatin/Epigenetic |
EED226 是多梳抑制复合物 2 抑制剂,是一种有效的、选择性的、可口服的胚胎外胚层发育 (EED) 抑制剂,IC50 为 22 nM,具有强抗肿瘤活性。当 H3K27me0 肽用作体外酶法测定的底物时,它抑制 PRC2的 IC50为 23.4 nM。 | |||
T2019 |
OAC2
|
OCT | Membrane transporter/Ion channel |
OAC2 是一种 Oct4 激活剂,通过 Oct4 基因启动子激活表达, 通过提高胚胎成纤维细胞诱导多能干细胞的产生速率来提高重编程效率,是 OAC1 的类似物。 | |||
T22322 |
EEDi-5285
UM-EEDi-5285,EEDI5285 |
Histone Methyltransferase | Chromatin/Epigenetic |
EEDi-5285 是一种非常有效且具有口服活性的胚胎外胚层发育 (EED) 抑制剂,结合 EED 蛋白的 IC50 值为 0.2 nM,并具有抗癌活性。 | |||
T2301 |
SB 202190
FHPI,SB202190 |
Apoptosis; p38 MAPK; Autophagy | Apoptosis; Autophagy; MAPK |
SB 202190 (FHPI) 是一种 p38 MAPK 抑制剂,可以抑制 p38α 和 p38β2 (IC50=50/100 nM),具有选择性和细胞渗透性。SB 202190 具有抗肿瘤活性,还可以诱导人胚胎干细胞向心肌细胞分化。 | |||
T60143 |
MitoBloCK-6
|
Apoptosis | Apoptosis |
MitoBloCK-6 是一种有效的Erv1/ALR 抑制剂,IC50分别为 900 nM 和 700 nM。MitoBloCK-6 还抑制Erv2,IC50值为1.4 μM。MitoBloCK-6 可通过释放细胞色素 c 诱导 hESCs 细胞凋亡。 | |||
T2310 |
CHIR-99021
Laduviglusib,CT99021,CHIR-99021 |
GSK-3; Wnt/beta-catenin; Autophagy | Autophagy; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Stem Cells |
CHIR-99021 (CT99021) 是一种 Wnt/β-catenin 信号通路激活剂,也是一种 GSK-3α/β抑制剂 (IC50=10/6.7 nM),具有选择性和口服活性。CHIR-99021 可以诱导细胞自噬,可增强小鼠和人类胚胎干细胞的自我更新。 | |||
T35834L |
(Sar¹)-Angiotensin II acetate
|
RAAS | Endocrinology/Hormones |
(Sar¹)-Angiotensin II acetate 是血管紧张素 II 的类似物,是血管紧张素 AT1 受体的特异性激动剂。它与富含脑膜的颗粒结合,Kd 为 2.7 nM。它可以刺激胚胎鸡肌细胞中的蛋白质合成和细胞生长。 | |||
TP1345 |
Kisspeptin-10, human (TFA)(374675-21-5,FREE)
|
GPR; Kisspeptin | Endocrinology/Hormones; GPCR/G Protein |
Kisspeptin-10, human (TFA)(374675-21-5,FREE) 是一种有效的血管收缩剂和血管生成抑制剂。 Kisspeptin-10,人类 TFA 通过其受体 GPR54 充当肿瘤转移抑制因子。 Kisspeptin-10-GPR54系统在胚胎肾发育中发挥重要作用。 Kisspeptin-10/GPR54 信号通过 NFATc4 介导的 BMP2 表达诱导成骨细胞分化 | |||
T3637 |
Pifithrin-β hydrobromide
Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide) |
Ferroptosis; p53 | Apoptosis |
Pifithrin-β hydrobromide (Cyclic PFT-α) 是一种 p53 的抑制剂,可逆地阻断 p53 依赖性转录激活和细胞凋亡。IC50值为23 μM。 | |||
T28866 |
Stemazole
|
Apoptosis | Apoptosis |
Stemazole 是一种新型小分子人类干/祖细胞增殖激活剂 ,可促进人类胚胎干细胞的存活并保持干性 ,促进少突胶质细胞前体细胞在体外的存活。Stemazole 能显著提高细胞存活率和克隆形成数,并呈剂量依赖性,降低细胞凋亡率,促进运动功能障碍的恢复和髓鞘的修复。Stemazole 可作为脱髓鞘疾病的治疗剂,促进OPC 体外存活和体内再生。 | |||
T36935 |
PKUMDL-LC-101-D04
GPX4-Activator-1d4,PKUMDL-LC-101-D04 |
GPX | oxidation-reduction |
PKUMDL-LC-101-D04是一种高效的谷胱甘肽过氧化物酶4(GPX4)的异位激活剂,是一种铁死亡的调节剂。 当在无细胞试验中使用浓度为20 μM 时,GPX4活性增加到对照水平的150%;在野生型而非Gpx4-/-小鼠胚胎成纤维细胞(MEF)提取物中使用浓度为61 μM 时,GPX4活性增加到对照水平的150%。PKUMDL-LC-101-D04(200 μM)能减少胆固醇过氧化氢诱导的MEF 死亡。 | |||
T77697 |
BML-278
BML278,BML 278 |
Sirtuin; Histone Methyltransferase | Chromatin/Epigenetic; DNA Damage/DNA Repair |
BML-278 是一种 SIRT1 激活剂 ,EC150 值为 1 μM。BML-278 增加父本和母本原核中的 H3K9 甲基化并抑制 H3K9 乙酰化,可用于改善早期胚胎发育。BML-278 促使原代人间充质细胞的细胞周期停止在 G1/S 期,可用于延缓衰老。BML-278 减少 U937 细胞中的微管蛋白乙酰化,增加小鼠 C2C12 成肌细胞的线粒体密度。 | |||
T2310L |
CHIR-99021 HCl
CT99021 HCl,Laduviglusib HCl |
GSK-3 | PI3K/Akt/mTOR signaling; Stem Cells |
CHIR-99021 HCl (Laduviglusib HCl) 是GSK-3α/β的高效选择性抑制剂,IC50值分别为10 nM和6.7 nM。它对GSK-3表现出显著的选择性,对CDC2、ERK2和其他蛋白激酶的选择性超过500倍。此外,CHIR-99021 HCl 是Wnt/β-catenin信号通路的强大激活剂。此外,它在小鼠和人类胚胎干细胞中都表现出增强自我更新的能力。此外,拉杜维格西单盐酸盐诱导自噬[1][2][3]。 | |||
T70520 |
TWS-119
|
Others | Others |
TWS-119 is an inhibitor of glycogen synthase kinase-3β (GSK-3β) that induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells (ESCs). | |||
T70578 |
BX-795 hydrochloride
|
Others | Others |
BX-795 hydrochloride is a TBK1 and IKKε inhibitor. BX-795 is a potential maternal embryonic leucine zipper kinase inhibitor. | |||
T24129 |
HBX28258
HBX 28258,HBX-28258 |
Others | Others |
HBX28258 is a recombinant human USP7 protein inhibitor. In human colon cancer and embryonic kidney cell, it acts by binding the active site through a covalent mechanism and selectively inactivating USP7 protein. | |||
T84921 |
CITFA
|
Others | Others |
CITFA为一种GPER激动剂,能够促进E18大鼠胚胎海马神经元的神经突生长。 | |||
T40154 |
FTX-6058
|
Others | Others |
FTX-6058 is a potent orally active inhibitor targeting Embryonic Ectoderm Development (EED). It effectively induces HbF protein expression in both cell and murine models. This compound holds significant potential for researching select hemoglobinopathies such as sickle cell disease and β-thalassemia. | |||
T35549 |
Elsinochrome A
|
Others | Others |
Elsinochrome A is a perylenequinone fungal metabolite that has been found inHypomycesand has anticancer activity.1Photoactivation of elsinochrome A induces the production of singlet oxygen and apoptosis in R366.4 rhesus monkey embryonic stem cells and HCe-8693 colorectal carcinoma cells when used at concentrations ranging from 1 to 100 μM. 1.Ma, L., Tai, H., Li, C., et al.Photodynamic inhibitory effects of three perylenequinones on human colorectal carcinoma cell line and primate embryonic stem ... | |||
T40155 |
FTX-6058 hydrochloride
|
Others | Others |
FTX-6058 hydrochloride is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED), with the ability to induce HbF protein expression in both cell and murine models. This compound is particularly valuable in the research of select hemoglobinopathies, such as sickle cell disease and β-thalassemia. | |||
T73867 |
HTH-01-091 TFA
|
Others | Others |
HTH-01-091 TFA 是一种强效且选择性的maternal embryonic leucine zipper kinase (MELK)抑制剂,其IC50为 10.5 nM。HTH-01-091 TFA 还能抑制PIM1/2/3、RIPK2、DYRK3、smMLCK 和CLK2。HTH-01-091 TFA 可用于乳腺癌研究。 | |||
T69743 |
MEDS433
|
Others | Others |
MEDS433 is a dihydroorotate dehydrogenase inhibitor (IC50 1.2 nM). MEDS433 inhibited the in vitro replication of hCoV-OC43 and hCoV-229E, as well as of SARS-CoV-2, at low nanomolar range. Notably, the anti-SARS-CoV-2 activity of MEDS433 against SARS-CoV-2 was also observed in kidney organoids generated from human embryonic stem cells. | |||
T69195 |
UC-857993
|
Others | Others |
UC-857993 是一种选择性SOS1-Ras 抑制剂 (Kd=14.7 μM, His6-SOS1cat),抑制其催化活性。UC-857993 还能抑制ERK 和Ras 激活,抑制小鼠胚胎成纤维细胞 (MEF) 的生长。 | |||
T73945 |
MAK683-CH2CH2COOH hydrochloride
|
Others | Others |
MAK683-CH2CH2COOH 与 EED (胚胎外胚层发育蛋白) 结合。MAK683-CH2CH2COOH 和 E3 泛素连接酶的 VHL 配体设计了 PROTACEED degrader-1 和 PROTACEED degrader-2 。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T19720 |
Colcemid
C 12669,C-12669,NSC-3096,Kolchicin,C12669,Demecolcine |
Microtubule Associated | Cytoskeletal Signaling |
Colcemid (NSC-3096) 是一种微管聚合抑制剂,可诱导细胞凋亡,可用于肿瘤和胚胎克隆的研究。 | |||
T4S1102 |
Liensinine diperchlorate
莲心碱高氯酸盐,莲心碱二高氯酸盐,Liensinine-Perchlorate |
Mitophagy; Others; Autophagy | Autophagy; Others |
Liensinine Diperchlorate 是从芙蕖种子胚中提取的一种异喹啉生物碱。它通过阻断自噬小体-溶酶体融合来抑制晚期自噬,具有抗心律不齐、抗高血压、抗肺纤维化和血管平滑肌松弛等生物学活性。 | |||
T75661 |
Thymopentin acetate
|
Others | Others |
Thymopentin acetate为胸腺皮质及髓质上皮细胞主要分泌的生物活性肽,是一有效免疫调节剂,具有极短的血浆半衰期(30秒),能促进自人类胚胎干细胞生成T细胞群。 | |||
T36954 |
Nemorosone
|
Others | Others |
Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 μM).2 It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nem... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02379 |
EED Protein, Human, Recombinant (His & GST)
HEED,WAIT1,embryonic ectoderm development |
Human | Baculovirus Insect Cells |
EED is essential for regulating the repressive histone modification, histone 3 lysine 27 tri-methylation (H3K27me3) at many developmental genes. EED depletion significantly impeded erythroid maturation. EED depletion impaired the generation of hematopoietic stem cells. The function of EED within polycomb repressive complex 2 (PRC2) is mediated by a complex network of protein-protein interactions. The targeted disruption of EED's reader function can lead to allosteric inhibition of PRC2 catalyti... | |||
TMPY-04126 |
MUSTN1 Protein, Human, Recombinant (His)
musculoskeletal, embryonic nuclear protein 1,MUSTAN... |
Human | E. coli |
MUSTN1 (Musculoskeletal, Embryonic Nuclear Protein 1) is a Protein Coding gene. It may play an important role in regulating musculoskeletal development in mammals. It belongs to the MUSTANG family. The MUSTN1 protein is localized to the nucleus in the myocardium and skeletal muscle fibers. It was expressed the greatest in skeletal muscle. The greatest relative growth rates appeared at the highest expression levels of the MUSTN1 gene, it was thought to play roles in duck muscle development. MUSTN... | |||
TMPH-02301 |
VPS35 Protein, Human, Recombinant (His & Myc)
VPS35,Vacuolar protein sorting-associated protein 35,Vesicle... |
Human | E. coli |
Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of... | |||
TMPH-01642 |
MELK Protein, Human, Recombinant (His & Myc)
Protein kinase Eg3,Tyrosine-protein kinase MELK,Protein kina... |
Human | E. coli |
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. ... | |||
TMPH-02023 |
Renin receptor Protein, Human, Recombinant (His)
Vacuolar ATP synthase membrane sector-associated protein M8-... |
Human | E. coli |
Renin receptor Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPY-03104 |
FGF-17 Protein, Human, Recombinant
fibroblast growth factor 17,HH20,FGF-13,FGF-17 |
Human | E. coli |
FGF-13, also known as FGF17, belongs to the fibroblast growth factor (FGF) family. Members of this family show broad mitogenic and cell survival activities, and play a role in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-13 is preferentially expressed in the embryonic brain. It interacts with FGFR3 and FGFR4. FGF-13 plays an important role in the regulation of embryonic development and as signaling mol... | |||
TMPJ-00090 |
FGF-9 Protein, Human, Recombinant
Fibroblast Growth Factor 9,Heparin-Binding Growth Factor 9,F... |
Human | E. coli |
Fibroblast Growth Factor 9 (FGF-9) belongs to the Fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-9 plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. In addition, FGF-9 may have a role in glial c... | |||
TMPY-01061 |
FGF-10 Protein, Human, Recombinant
fibroblast growth factor 10,KGF2 |
Human | E. coli |
Fibroblast growth factor 10 (FGF10) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF10 exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. FGF10 pla... | |||
TMPY-03382 |
FGF-6 Protein, Human, Recombinant
HBGF-6,HST2,fibroblast growth factor 6 |
Human | E. coli |
FGF6, also known as FGF-6, belongs to the fibroblast growth factor (FGF) family. Members of this family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF6 plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis. It is also required for normal muscle regeneration. FGF6 gene d... | |||
TMPJ-00842 |
FGF-2 Protein, Rat, Recombinant
bFGF,Heparin-Binding Growth Factor 2,FGFB,Fibroblast Growth ... |
Rat | E. coli |
FGF-basic is a members of the Fibroblast Growth Factors (FGFs) family. The family constitutes a large family of proteins involved in many aspects of development including cell proliferation, growth, and differentiation. They act on several cell types to regulate diverse physiologic functions including angiogenesis, cell growth, pattern formation, embryonic development, metabolic regulation, cell migration, neurotrophic effects, and tissue repair. FGF-basic is a non-glycosylated heparin binding g... | |||
TMPJ-00258 |
TGF beta 2 Protein, Human, Recombinant
Glioblastoma-derived T-cell suppressor factor,TGF-β-2,Transf... |
Human | HEK293 Cells |
Transforming growth factor beta-2 (TGF-β2) is a secreted protein which belongs to the TGF-beta family. It is known as a cytokine that performs many cellular functions and has a vital role during embryonic development. The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive. It is an extracellular glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumors. Defects in TGFB2 may be... | |||
TMPJ-01471 |
Activin A Protein, Human, Mouse, Rat, Cynomolgus, Rhesus, Recombinant
Activin A,INHBA,Inhibin beta A chain,Inhibin β A chain |
Human/Mouse/Rat | HEK293 Cells |
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell developm... | |||
TMPJ-00562 |
PDGF-BB Protein, Mouse, Recombinant (His)
PDGFBB,PDGF-BB,血小板源生长因子 |
Mouse | E. coli |
Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. As growth factor,it plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival... | |||
TMPY-02907 |
FGF-19 Protein, Human, Recombinant
fibroblast growth factor 19,FGF19 |
Human | E. coli |
FGF19, also known as FGF-19, is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF19 interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL, KLB and heparan sulfate glycosaminoglyca... | |||
TMPY-05004 |
FGF-4 Protein, Human, Recombinant
HST-1,KFGF,fibroblast growth factor 4,HSTF1,K-FGF,HST,HBGF-4 |
Human | E. coli |
FGF (fibroblast growth factor) signalling is known to be required for many aspects of mesoderm formation and patterning during Xenopus development and has been implicated in regulating genes required for the specification of both blood and skeletal muscle lineages. Fibroblast growth factor 4 (FGF4) signaling induces differentiation from embryonic stem cells (ESCs) via the phosphorylation of downstream molecules such as mitogen-activated protein kinase/extracellular signal-related kinase (MEK) a... | |||
TMPJ-00037 |
FGF-2 Protein, Mouse, Recombinant
Fibroblast Growth Factor 2,bFGF,HBGF-2,Basic Fibroblast Grow... |
Mouse | E. coli |
FGF basic is one of 22 mitogenic proteins of the FGF family, which show 35-60% amino acid conservation. Unlike other FGFs, FGF acidic and basic lack signal peptides and are secreted by an alternate pathway. The 17 kDa mouse sequence has 98% aa identity with rat, and 95% identity with human, bovine, and sheep FGF basic. Binding of FGF to heparin or cell surface HSPG is necessary for binding, dimerization and activation of tyrosine kinase FGF receptors. FGF basic binds other proteins, polysacchari... | |||
TMPJ-01065 |
Noggin/NOG Protein, Mouse, Recombinant (His)
Nog,Noggin |
Mouse | HEK293 Cells |
Noggin is a secreted homodimeric glycoprotein that is an antagonist of bone morphogenetic proteins (BMPs). Mouse Noggin cDNA encodes a 232 amino acid (aa) residue precursor protein with 19 aa residue putative signal peptide that is cleaved to generate the 213 aa residue mature protein which is secreted as a homodimeric glycoprotein. Secreted Noggin probably remains close to the cell surface due to its binding of heparin-containing proteoglycans. Noggin binds some BMPs such as BMP4 with high affi... | |||
TMPJ-01011 |
FGF-9 Protein, Mouse, Recombinant (His)
heparin-binding growth factor-9,GAF,HBGF-9,Glia-activating f... |
Mouse | E. coli |
Fibroblast growth factor-9 (FGF-9) is an approximately 26 kDa secreted glycoprotein of the FGF family. Secreted mouse FGF-9 lacks the N-terminal 1-3 aa and shares >98% sequence identity with rat, human, equine, porcine and bovine FGF-9. FGF-9 plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. In the mouse embryo the location and timing of FGF-9 expression affects development of the skeleton, cerebellum, lungs, heart, v... | |||
TMPJ-00412 |
VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)
Vascular endothelial growth factor receptor 1,Vascular perme... |
Human | HEK293 Cells |
Human Vascular endothelial growth factor receptor 1(VEGFR-1, FLT-1) is a member of the the class III subfamily of receptor tyrosine kinases (RTKs) and Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 is widely expressed in human tissues including normal lung, placenta, liver, kidney, heart and brain tissues. It is specifically expressed in most of the vascular endothelial cellsand peripheral blood monocytes. VEGFR-1 contains seven Ig-like C2-type domains and one protein kinas... | |||
TMPJ-00096 |
FGF-17 Protein, Human, Recombinant (His)
Fibroblast Growth Factor 17,FGF17,FGF-17 |
Human | HEK293 Cells |
Fibroblast Growth Factor 17 (FGF17) is a member of the heparin-binding growth factors family that is prominently expressed in the cerebellum and cortex. Proteins of this family possess broad mitogenic and cell survival activities and they are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth, and invasion. FGF17 plays an important role in the regulation of embryonic development and it acts as signaling molecule i... | |||
TMPH-01895 |
POU5F1 Protein, Human, Recombinant (B2M & His)
Octamer-binding protein 4,Octamer-binding protein 3,POU5F1,O... |
Human | E. coli |
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. POU5F1 Protein, Human, Recombinant (B2M & His) is expressed in E. coli expression system with N-6xHis-B2M tag. The predicted molecular weight is 52.6 kDa and the accession number is Q... | |||
TMPH-02858 |
Wnt2 Protein, Mouse, Recombinant (His)
Protein Wnt-2,INT-1-related protein,Wnt2 |
Mouse | E. coli |
Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons. | |||
TMPH-01602 |
LAMA5 Protein, Human, Recombinant (His & SUMO)
LAMA5,Laminin subunit alpha-5,Laminin-15 subunit alpha,Lamin... |
Human | E. coli |
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. | |||
TMPJ-00677 |
TGOLN2 Protein, Human, Recombinant (His)
Trans-Golgi network protein TGN51,TGN38 homolog,TGN51,TGN46,... |
Human | HEK293 Cells |
This protein may be involved in regulating membrane traffic to and from trans-Golgi network. Isoform TGN46 is widely expressed. Isoform TGN51 is more abundant in fetal lung and kidney. Isoform TGN48 is barely expressed in embryonic kidney and promyelocytic cells. | |||
TMPH-03321 |
KRTDAP Protein, Rat, Recombinant (His & SUMO)
Keratinocyte differentiation-associated protein,Krtdap |
Rat | E. coli |
May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis. KRTDAP Protein, Rat, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 21.5 kDa and the accession number is P85411. | |||
TMPH-01355 |
FXR1 Protein, Human, Recombinant (His)
FXR1,RNA-binding protein FXR1,FMR1 autosomal homolog 1,hFXR1... |
Human | E. coli |
RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs. FXR1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 70.5 kDa and the accession number is P51114. | |||
TMPJ-00835 |
FGF-4 Protein, Mouse, Recombinant
HSTF1,HST-1,FGF4,FGF-4,HBGF-4,Fibroblast growth factor 4,HST... |
Mouse | E. coli |
Fibroblast growth factor 4(FGF-4) is a heparin binding member of the FGF family. The human FGF4 cDNA encodes 206 amino acids (aa) with a 33 aa signal sequence and a 173 aa mature protein with an FGF homology domain that contains a heparin binding region near the C-terminus. Mature human FGF4 shares 91%, 82%, 94% and 91% aa identity with mouse, rat, canine and bovine FGF4, respectively. Human FGF-4 has been shown to exhibit cross species activity. Expression of FGF-4 and its receptors, FGF R1c, 2... | |||
TMPK-00868 |
Notch 4 Protein, Mouse, Recombinant (His)
Notch-4,Int-3,Notch4,Int3 |
Mouse | HEK293 Cells |
The Notch signaling pathway is important for cell-cell communication; it is involved in gene regulation mechanisms that control multiple cell differentiation processes during embryonic and adult life. Notch-4 expression correlates with Ki67. Notch-4 also plays a key role in breast cancer stem-like cells. | |||
TMPH-02293 |
UGDH Protein, Human, Recombinant (His & SUMO)
UDP-glucose 6-dehydrogenase,UGDH |
Human | E. coli |
Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans. Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans. Required for proper brain and neuronal development. | |||
TMPH-00068 |
Vitellogenin Protein, Apis mellifera, Recombinant (His)
Vitellogenin,Vg |
Apis mellifera | E. coli |
Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development. Involved in the differentiation of honeybee larvae into queens. Vitellogenin Protein, Apis mellifera, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 32.5 kDa and the accession number is Q868N5. | |||
TMPH-02865 |
Wnt3 Protein, Mouse, Recombinant (His & SUMO)
Proto-oncogene Int-4,Proto-oncogene Wnt-3,Wnt3 |
Mouse | E. coli |
Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge and for normal embryonic limb development. | |||
TMPJ-01300 |
PDCD10 Protein, Human, Recombinant
TFAR15,Programmed Cell Death Protein 10,PDCD10,TF-1 Cell Apo... |
Human | E. coli |
Programmed Cell Death Protein 10 (PDCD10) belongs to the PDCD10 family. PDCD10 exists as a homodimer and is widely expressed. PDCD10 can increase mitogen-activated protein kinase activity and MST4 activity. PDCD10 is required for normal cardiovascular development and normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development. Defects in PDCD10 are the cause of cerebral cavernous malformations type 3. | |||
TMPK-01186 |
B7-H5/Gi24/VISTA Protein, Human, Recombinant (His)
VSIR,B7H5,4632428N05Rik,SISP1,PP2135,Dies1,PD-1H,VISTA,C10or... |
Human | HEK293 Cells |
B7-H5, also known as VISTA , B7H5, Dies1, SISP1 and C10orf54, is a 55-65 kDa member of the Ig superfamily. It is a transmembrane molecule expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. B7-H5/Gi24/VISTA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 19 kDa and the accession number is Q9H7M9. | |||
TMPJ-00879 |
HOXB4 Protein, Human,Recombinant (L175D, E176K, E178K, His)
Homeobox protein Hox-2.6,HOX2F,HOXB4,Homeobox protein Hox-2F... |
Human | E. coli |
Homeobox B4 (HOXB4) is encoded by the HOXB4 gene which is a member of the the class I homeobox (HOX) gene family and encodes a nuclear protein with a homeobox DNA-binding domain. These genes are master control regulators of developmental programs including embryonic and adult hematopoiesis. Multiple HOX genes, including HOXB4, are highly expressed in the hematopoietic stem cells (HSC) compartment. HOXB4 gene can act in opposite ways when expressed by different cells, promoting the proliferation ... | |||
TMPK-01185 |
B7-H5/Gi24/VISTA Protein, Human, Recombinant (hFc)
PP2135,SISP1,VISTA,Gi24,B7H5,4632428N05Rik,Dies1,PD1H,VSIR,B... |
Human | HEK293 Cells |
B7-H5, also known as VISTA , B7H5, Dies1, SISP1 and C10orf54, is a 55-65 kDa member of the Ig superfamily. It is a transmembrane molecule expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. B7-H5/Gi24/VISTA Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 44.9 kDa and the accession number is Q9H7M9. | |||
TMPK-00233 |
CEACAM6 Protein, Human, Recombinant (aa 35-320, His & Avi), Biotinylated
NCA,CEACAM6,CEA,CD66c,CEAL |
Human | HEK293 Cells |
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) belongs to the human carcino-embryonic antigen (CEA) family. Numerous lines of studies have indicated that altered expression of CEACAM6 may have a role in carcinogenesis and development. CEACAM6 Protein, Human, Recombinant (aa 35-320, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 34.1 kDa and the accession number is P40199. | |||
TMPK-00232 |
CEACAM6 Protein, Human, Recombinant (His & Avi)
CEA,CD66c,CEAL,CEACAM6,NCA |
Human | HEK293 Cells |
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) belongs to the human carcino-embryonic antigen (CEA) family. Numerous lines of studies have indicated that altered expression of CEACAM6 may have a role in carcinogenesis and development. CEACAM6 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 34.1 kDa and the accession number is P40199. | |||
TMPK-01311 |
CEACAM6 Protein, Cynomolgus, Recombinant (aa 35-320, His)
CEACAM6,CEAL,CEA,NCA,CD66c |
Cynomolgus | HEK293 Cells |
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) belongs to the human carcino-embryonic antigen (CEA) family. Numerous lines of studies have indicated that altered expression of CEACAM6 may have a role in carcinogenesis and development. CEACAM6 Protein, Cynomolgus, Recombinant (aa 35-320, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 32.73 kDa and the accession number is XP_014979566.2. | |||
TMPY-04003 |
UNC5B Protein, Rat, Recombinant (hFc)
unc-5 homolog B (C. elegans) |
Rat | HEK293 Cells |
The netrin-1 receptor, UNC-5 Homology B, or UNC5B plays vital roles in angiogenesis, inflammation, embryonic development and carcinogenesis. Overexpression of UNC5B human colon epithelial cells suppressed dextran sodium sulfate, or DSS-induced apoptosis and caspase-3 activity. Besides, is a potential anti-neoplastic target in bladder cancer progression and inflammatory arthritis. UNC5B Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular we... | |||
TMPY-04828 |
TFF3 Protein, Human, Recombinant (His)
trefoil factor 3 (intestinal),ITF,P1B,TFI |
Human | HEK293 Cells |
Trefoil factor family (TFF) peptides are involved in the maintenance of epithelial integrity and epithelial restitution. Trefoil factor-3 (TFF3) is an estrogen-regulated gene associated with prognosis in different types of cancer. The presence and localization of TFF3 peptide was associated with the embryonic stage and tissue differentiation. TFF3 peptide distribution specific to the germ layers was not observed. The role of TFF3 peptide in cell migration and differentiation, immune response, an... | |||
TMPK-00453 |
HER3/ERBB3 Protein, Human, Recombinant (His & Avi)
p45-sErbB3,MDA-BF-1,ErbB-3,HER3c-erbB-3,ErbB3,MGC88033,LCCS2... |
Human | HEK293 Cells |
Her3, also called ErbB3, is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors.Her3 is expressed in keratinocytes, melanocytes, skeletal muscle cells, embryonic myoblasts and Schwann cells. Monomeric Her3 serves as a low affinity receptor for the heregulins (HRG). HER3/ERBB3 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 71.6 kDa and the accession number is P21860-1. | |||
TMPK-00452 |
HER3/ERBB3 Protein, Human, Recombinant (His & Avi), FITC-Labeled
LCCS2,HER3c-erbB-3,p180-ErbB3,MGC88033,ErbB3,p85-sErbB3,p45-... |
Human | HEK293 Cells |
Her3, also called ErbB3, is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors.Her3 is expressed in keratinocytes, melanocytes, skeletal muscle cells, embryonic myoblasts and Schwann cells. Monomeric Her3 serves as a low affinity receptor for the heregulins (HRG). HER3/ERBB3 Protein, Human, Recombinant (His & Avi), FITC-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 71.6 kDa and the accession numbe... | |||
TMPK-01280 |
HER3/ERBB3 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)
p85-sErbB3,HER3,LCCS2,p180-ErbB3,HER3c-erbB-3,ErbB-3,ERBB3,M... |
Cynomolgus,Rhesus | HEK293 Cells |
Her3, also called ErbB3, is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors.Her3 is expressed in keratinocytes, melanocytes, skeletal muscle cells, embryonic myoblasts and Schwann cells. Monomeric Her3 serves as a low affinity receptor for the heregulins (HRG). HER3/ERBB3 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 69.54 kDa and the accession number i... | |||
TMPJ-00752 |
HBAZ Protein, Human, Recombinant (His)
Hemoglobin Subunit Zeta,Hemoglobin ζ Chain,Hemoglobin Zeta C... |
Human | E. coli |
Hemoglobin Subunit Zeta (HBZ) is a member of the Globin family. The zeta chain is an alpha-type chain of mammalian embryonic Hemoglobin that is synthesized primarily in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal growth and adult life. The HBZ gene consists of five functional genes and two pseudogenes, the order of genes is 5-zeta-pseudozeta-mu-pseudoalpha-1-alpha-2-alpha-1-theta-1-3. | |||
TMPJ-00692 |
GAS7 Protein, Human, Recombinant (His)
GAS-7,GAS7,Growth Arrest-Specific Protein 7,KIAA0394 |
Human | E. coli |
Growth Arrest-Specific Protein 7 (GAS7) is expressed primarily in terminalaly differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 may play a role in neuronal development by promoting maturation and morphological differentiation of cerebellar neurons. Inhibition of GAS7 production in terminally differentiating cultures of embryonic murine cerebullum impedes neurite outgrowth. The hyper-expression of GAS7 may play an major role in the initiation and development... | |||
TMPH-02864 |
Wnt1 Protein, Mouse, Recombinant (His & Myc)
Proto-oncogene Wnt-1,Wnt1,Proto-oncogene Int-1 |
Mouse | E. coli |
Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Plays an essential role in the development of the embryonic brain and central nervous system (CNS). Has a role in osteoblast function, bone development and bone homeostasis. | |||
TMPK-00520 |
PTK7/CCK4 Protein, Cynomolgus, Recombinant (His)
PTK7,CCK-4 |
Cynomolgus | HEK293 Cells |
Protein Tyrosine Kinase 7 (PTK7) is as a critical regulator of canonical and non-canonical Wnt-signaling during embryonic development and cancer cell formation. Disrupting PTK7 activity perturbs vertebrate nervous system development, and also promotes human cancer formation. Observations in different model systems suggest a complex cross-talk between PTK7 protein and Wnt signaling. PTK7/CCK4 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predict... | |||
TMPY-00507 |
UNC5B Protein, Human, Recombinant (hFc)
unc-5 homolog B (C. elegans),UNC5H2,p53RDL1 |
Human | HEK293 Cells |
The netrin-1 receptor, UNC-5 Homology B, or UNC5B plays vital roles in angiogenesis, inflammation, embryonic development and carcinogenesis. Overexpression of UNC5B human colon epithelial cells suppressed dextran sodium sulfate, or DSS-induced apoptosis and caspase-3 activity. Besides, is a potential anti-neoplastic target in bladder cancer progression and inflammatory arthritis. UNC5B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular ... | |||
TMPY-04133 |
UNC5B Protein, Human, Recombinant (His)
UNC5H2,p53RDL1,unc-5 homolog B (C. elegans) |
Human | HEK293 Cells |
The netrin-1 receptor, UNC-5 Homology B, or UNC5B plays vital roles in angiogenesis, inflammation, embryonic development and carcinogenesis. Overexpression of UNC5B human colon epithelial cells suppressed dextran sodium sulfate, or DSS-induced apoptosis and caspase-3 activity. Besides, is a potential anti-neoplastic target in bladder cancer progression and inflammatory arthritis. UNC5B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular ... | |||
TMPK-01093 |
Kremen-2 Protein, Mouse, Recombinant (His)
KRM2,KREMEN2,Dickkopf receptor 2,Kremen-2 |
Mouse | HEK293 Cells |
Kremen2 (Krm2) plays an important role in embryonic development, bone formation, and tumorigenesis as a crucial regulator of classical Wnt/β-catenin signaling pathway. Compared to para-cancerous tissues, Krm2 was significantly up-regulated in gastric cancer tissues and was positively correlated with the pathological grade of gastric cancer patients. Krm2 can be a potent candidate for designing of targeted therapy. Kremen-2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells ... | |||
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