37
5
16
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7100 |
PLX5622
PLX-5622 |
c-Fms; CSF-1R | Tyrosine Kinase/Adaptors |
PLX5622 是一种选择性的、高效的、能透过血脑屏障的、口服具有活性的 CSF1R 抑制剂 (IC50= 0.016 µM;Ki= 5.9 nM),具有较好的药理学特性,可用于病程发展前和过程中,扩大的和特异性的小胶质细胞的消除。 | |||
T4989 |
Fosfomycin Tromethamine
|
Antibacterial; Antibiotic | Microbiology/Virology |
Fosfomycin tromethamine 是一种能透过血脑屏障的广谱抗生素,不可逆地抑制细胞壁合成的早期阶段。它对多种细菌具有杀菌活性,包括耐多药、广泛耐药和耐全药细菌。 | |||
T3131 |
Fosfomycin calcium
Phosphomycin calcium salt,Fosmicin,磷霉素钙 |
Antibacterial; Antibiotic | Microbiology/Virology |
Fosfomycin calcium (Phosphomycin calcium salt) 是一种能透过血脑屏障的广谱抗生素,不可逆地抑制细胞壁合成的早期阶段。它对多种细菌具有杀菌活性,包括耐多药、广泛耐药和耐全药细菌。 | |||
T15604 |
IU1-47
|
DUB | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination |
IU1-47 是一种特异性 USP14抑制剂,IC50为 0.6 μM。它诱导培养的神经元中 tau 蛋白降解。它抑制 IsoT/USP5, IC50为 20 μM。 | |||
T62525 |
TP-16
|
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
TP-16是一种新型高效且具有选择性的 EP4 拮抗剂,可阻断IMCs的功能,增强细胞毒性T细胞介导的体内肿瘤消除。 | |||
T15251 |
Etebenecid
乙磺舒,Urelim |
Others | Others |
Etebenecid (Urelim) 是促尿酸排泄药,能够抑制青霉素自肾小管分泌。 | |||
T72028 |
2-Quinolinecarboxaldehyde
Quinoline-2-carbaldehyde |
Others | Others |
2-Quinolinecarboxaldehyde (Quinoline-2-carbaldehyde) 是一个小的刚性分子,是在亨利反应和随后的消除中的一个化合物。2-Quinolinecarboxaldehyde 抑制 AChE,IC50 为 13.48 μM。 | |||
T6397 |
Atracurium besylate
Tracrium,51W89,BW-33A,苯磺酸阿曲库铵 |
AChR | Neuroscience |
Atracurium besylate (51W89) 是一种神经肌肉阻断剂,ED95为0.2 mg/kg。 | |||
T5117 |
Hexaflumuron
|
Others | Others |
Hexazinone 是一种三嗪家族的非选择性除草剂。它能够同光系统 II 电子传递链的 D-1 醌蛋白结合,抑制光合作用的发生。 | |||
T0195 |
Secnidazole
RP-14539,PM-185184,塞克硝唑 |
Antibiotic; Parasite | Microbiology/Virology |
Secnidazole (PM-185184) 是一种具有口服活性唑类抗生素,半衰期比甲硝唑更长。它有潜力研究细菌性阴道病。 | |||
T40795 |
BNTA
|
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
BNTA 是一种有效的细胞外基质 (ECM) 调节剂。在大鼠关节炎模型中,BNTA 通过诱导超氧化物歧化酶 3 (SOD3) 促进软骨细胞上软骨结构分子的合成和超氧阴离子消除调节软骨生成从而调节关节炎。 | |||
T8947 |
dasiglucagon acetate
dasiglucagon acetate(1544300-84-6 free base) |
Others | Others |
dasiglucagon acetate 是一种用于糖尿病低血糖治疗的新型胰高血糖素类似物。 它已证明在水性制剂中的溶解度和稳定性。药代动力学研究表明,与传统的重组胰高血糖素相比,它的胰高血糖素具有更高的吸收率和更长的血浆消除半衰期。 | |||
T0153 |
Oltipraz
吡噻硫酮,NSC 347901,RP 35972 |
HIF/HIF Prolyl-Hydroxylase; HIV Protease; Reverse Transcriptase; Nrf2; HIF | Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; Microbiology/Virology; Proteases/Proteasome |
Oltipraz (RP 35972) 是一种 Nrf2的强效激活剂。它时间依赖性地抑制 HIF-1α激活,IC50为 10 μM,浓度 ≥ 10 μM 时完全消除 HIF-1α诱导。 | |||
T33291 |
Meproscillarin
KY-18,Rambufaside,Clift,KY 18,KY18 |
Others | Others |
Meproscillarin is a glycoside with high bioavailability (about 70%) and an elimination independent of renal function. | |||
T29075 |
UR-7247
UR7247 |
Others | Others |
UR-7247 is an angiotensin type 1 receptor antagonist with a very long plasma elimination half-life. | |||
T14682 |
BMS-962212
|
Others | Others |
BMS-962212, a direct, reversible, and selective factor XIa (FXIa) inhibitor, demonstrates fast pharmacodynamic (PD) response onset and rapid elimination with a well-tolerated profile. It dependently increases activated partial thromboplastin time and decreases FXI clotting activity exposure [1]. | |||
T30118 |
Arbaclofen placarbil
XP 19986,XP19986,XP-19986 |
Others | Others |
Arbaclofen placarbil( XP19986) is a GABA(B) receptor agonist.Arbaclofen Placarbil is a novel R-baclofen prodrug with improved absorption, distribution, metabolism, and elimination properties compared to R-baclofen. And it can reduce postprandial reflux in | |||
T17903 |
Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH
E3 ligase Ligand-Linker Conjugates 49,Cereblon Ligand-Linker Conjugates 14 |
Others | Others |
Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH is a chemically synthesized compound, designed as an E3 ligase ligand-linker conjugate, integrating the cereblon ligand derived from Pomalidomide and a linker employed in PROTAC technology. This compound serves to facilitate targeted protein degradation through the modulation of E3 ligase activity, enabling the selective elimination of specific proteins of interest. | |||
T18598 |
PROTAC BRD2/BRD4 degrader-1
|
Others | Others |
PROTAC BRD2/BRD4 degrader-1 (compound 15) serves as a potent, selective degrader of BET proteins BRD4 and BRD2, achieving rapid, reversible, and unexpectedly selective elimination of BRD4 and BRD2 compared to BRD3. Its efficacy in suppressing solid tumors manifest with minimal cytotoxic effects. This compound comprises a BET inhibitor, a connecting linker, and thalidomide as the ligand for cereblon (CRBN)/cullin 4A[1]. | |||
T76040 |
Dusquetide TFA
|
Others | Others |
Dusquetide (SGX942) TFA 是一类天然防御调节因子(IDR)。Dusquetide TFA 通过与 p62 结合调节 PAMPs 和 DAMPs 的天然免疫应答。Dusquetide TFA 在减轻炎症和增加细菌感染清除方面都显示出活性。 | |||
T68765 |
Spirorenone
|
Others | Others |
Spirorenone is an androstadienone derivative as a highly effective aldosterone antagonist. Spirorenone is 8.6 times as potent as spironolactone, but showed a lower affinity for the mineralocorticoid receptors. In phase I clinical trials Spirorenone was absorbed with a half-life of 20-30 min, achieving maximum concentrations of about 100 ng/ml (10 mg) and 260 ng/ml (40 mg) after 1-2 h. Disposition of the parent drug was biphasic with half-lives of 50-60 min (distribution) and 5-6 h (elimination).... | |||
T76959 | Vibecotamab | ||
Vibecotamab (XmAb14045) 是一种有效的针对 CD123和 CD3的双特异性抗体,可刺激 T 细胞介导的 CD123 表达细胞的靶向杀伤。Vibecotamab 具有抗肿瘤活性,可用于急性髓系白血病研究。 | |||
T12505 |
PLX5622 hemifumarate
|
c-Fms | Tyrosine Kinase/Adaptors |
PLX5622 hemifumarate 是高度选择性的、能透过血脑屏障的、具有口服活性的 CSF1R 抑制剂,IC50值为 0.016 μM,Ki 值为 5.9 nM,可用于病程发展前和过程中,扩大和特异性的小胶质细胞的消除。PLX5622 hemifumarate 具有较理想的药代动力学特性。 | |||
T76227 |
LS-BF1
|
Others | Others |
LS-BF1是一种阳性抗菌肽,具有稳定性和低毒性特点。该化合物能通过破坏细胞膜机制,对包括ESKAPE病原体在内的广泛微生物表现出有效的抗菌活性。在小鼠感染模型测试中,LS-BF1展现了优异的体内抑菌效果。 | |||
T76845 | Sotrovimab | ||
Sotrovimab (VIR 7831)为一种人源化IgG1κ泛冠状病毒(sarbecvirus)单克隆抗体,能够中和SARS-CoV-2、SARS-CoV-1以及其他多种冠状病毒。该药物基于S309研发,拥有较长半衰期,在呼吸道黏膜中展现出较高的生物利用度。Sotrovimab有助于免疫介导的病毒清除,预防Covid-19早期发展。 | |||
T79929 |
L-Methionine γ-lyase
Methionine lyase |
Others | Others |
L-Methionine γ-lyase(Methionine lyase)是一种依赖磷酸吡哆醛的多功能酶,专门催化L-蛋氨酸(L-methionine)及其类似物的α, γ-裂解反应。该酶因其抗癌和抗感染活性被用于相关疾病的研究,同时也适用于同型半胱氨酸血症研究领域。 | |||
T77228 |
Polyoxyethylene Sorbitan Monostearate
|
Others | Others |
Polyoxyethylene Sorbitan Monostearate 是一种由饱和脂肪酸硬脂酸 (C18:0) 构成的酯,广泛应用作药用辅料,包括表面活性剂、乳化剂、增溶剂和润湿剂。作为药用助剂,其主要作用是改善药物制剂的稳定性、溶解性和加工性,同时对药物的吸收、分布、代谢和消除 (ADME) 过程具有影响。 | |||
T77254 |
Maltodextrin, dextrose equivalent 16.5-19.5
|
Others | Others |
Maltodextrin(麦芽糊精),dextrose equivalent(葡萄糖当量)为16.5-19.5,可作为药用辅料。药用辅料,亦称药用助剂,非药物成分的化学物质,用于辅助药物制剂过程。此类辅料提升药物制剂的稳定性、溶解性及加工性,同时影响药物的吸收、分布、代谢及排泄(ADME)过程。 | |||
T71539 |
AFN-1252 tosylate hydrate
|
Others | Others |
AFN-1252, also known as AFN-12520000; API-1252; Debio-1452, is FASII Inhibitor which is potentially for the treatment of acute bacterial skin. AFN-1252 exhibits typical MIC(90) values of ≤0·015 μg/ml against diverse clinical isolates of S. aureus, oral absorption, long elimination half-live and efficacy in animal models. AFN-1252 efficiently blocked daptomycin-induced phospholipid decoy production, even in the case of isolates resistant to AFN-1252, which prevented the inactivation of daptomyci... | |||
T76980 | Tidutamab | ||
Tidutamab (XmAb-18087) 是一种具有完整 Fc 结构域的人源化及亲和优化双特异性抗体(bsAb),旨在通过SSTR2和CD3两个靶点特异性结合来延长血清半衰期,通过激活T细胞介导的细胞毒性(RTcC)机制,有效消除SSTR+肿瘤细胞。 | |||
T74583 |
Desmethylazelastine
|
Others | Others |
Desmethylazelastine是Azelastine经由细胞色素P450酶系统的氧化代谢形成的主要活性代谢物,具有97%的蛋白结合率和54小时的消除半衰期。Azelastine作为一种口服活性的组胺H1受体拮抗剂,特点是选择性高和亲和力强。它主要用于治疗过敏性鼻炎、哮喘、糖尿病高脂血症以及用于SARS-CoV-2的研究。 | |||
T75329 |
Cellulose
|
Others | Others |
Cellulose 可用作药用辅料。药用辅料或药用助剂,是指制药过程中使用的除药物成分以外的其他化学物质。药用辅料一般是指药物制剂中的非活性成分,能提高药物制剂的稳定性、溶解性和加工性。药用辅料还会影响合并用药的吸收、分布、代谢和消除 (ADME) 过程。 | |||
T36564 |
(S)-Acenocoumarol
|
Others | Others |
Acenocoumarol is a short-lived oral anti-coagulant, which, like warfarin, functions by inhibiting vitamin K epoxide reductase. It has higher intrinsic anticoagulant potency than warfarin and phenprocoumon, when evaluated in vitro. Acenocoumarol has a single chiral center that gives rise to two different enantiomeric forms. (S)-Acenocoumarol has a shorter plasma elimination half-life (1.8 hours) and faster plasma clearance (28.5 L/hour), compared to the (R)-enantiomer (6.6 hours, 1.9 L/hour). The... | |||
T73620 |
Poly(acrylic acid)
|
Others | Others |
Poly(acrylic acid) 通过吸附作用在金属表面形成保护层,有效抑制纯铸铝在酸性介质中的腐蚀现象。此外,Poly(acrylic acid) 还可作为药物制剂中的包衣材料、释放阻断剂等药用辅料使用。药用辅料,亦称药用助剂,是指在制药过程中,除药物活性成分外使用的其他化学物质。这些辅料通常作为非活性成分加入药物制剂中,旨在提升制剂的稳定性、溶解性及加工性。同时,药用辅料对药物的吸收、分布、代谢与排泄(ADME)过程也具有一定影响。 | |||
T84845 |
Trisodium phosphate dodecahydrate
Phosphoric acid, sodium salt, hydrate (1:3:12) |
Others | Others |
Trisodium phosphate dodecahydrate 在含0.1 M NaClO4的充气或脱气溶液中可作为铁的腐蚀抑制剂。此外,该化合物还能作为药用辅料,用于pH调节和缓冲,提升药物制剂的稳定性、溶解性及加工性。药用辅料,亦称药用助剂,是除药物活性成分外,在药物制造过程中使用的化学物质,对药物的吸收、分布、代谔和消除(ADME)过程具有影响。 | |||
T65387 |
Paromomycin, sulfate (1:1)
|
Others | Others |
Paromomycin (Sulfate Salt) is an aminoglycoside that is active against Gram-negative and many Gram-positive bacteria as well as some protozoa and cestodes. Paromomycin in combination with sodium stibogluconate has proven to be effective in African and Indian VL (visceral leishmaniasis) and improves survival in African VL[3]. PS (Paromomycin Sulfate) is effective for elimination of B. coli without hematological side effects[4]. The activity of phosphoglucose isomerase was slightly inhibited by 10... | |||
T37800 |
PF-04449613
|
Others | Others |
PF-04449613 is a phosphodiesterase 9A (PDE9A) inhibitor (IC50= 22 nM).1It is selective for PDE9A over PDE1C (IC50= >1,000 nM), as well as over a variety of other PDEs, inhibiting PDE2-8, -10, and -11 activity by less than 30% in a panel of enzymes, ion channels, and transporters at 1 μM but does inhibit the human dopamine transporter (DAT; Ki= 293 nM). PF-04449613 (0.1-100 mg/kg, s.c.) increases cerebrospinal fluid (CSF) levels of cyclic GMP (cGMP) in rats. Subcutaneous administration of PF-0444... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8262 |
Fosfomycin sodium
Fosfomycin Disodium,磷霉素钠 |
Antibacterial; Antibiotic | Microbiology/Virology |
Fosfomycin sodium 是一种能透过血脑屏障的广谱抗生素,不可逆地抑制细胞壁合成的早期阶段。它对多种细菌具有杀菌活性,包括耐多药、广泛耐药和耐全药的细菌。 | |||
T3875 |
CLINODISIDE A
|
Others | Others |
Clinodiside A 是来自中草药Clinopodium chinensis 中。 | |||
T8073 |
Disodium succinate
丁二酸二钠,Sodium succinate |
Others | Others |
Disodium succinate (Sodium succinate) 是 Succinic acid 的盐形式。Succinic acid 是无氧代谢的发酵产物,也是三羧酸循环的中间产物。 | |||
T5068 |
D-Glucuronic acid sodium salt monohydrate
Sodium D-glucuronate,D-葡糖醛酸钠一水,D-葡萄糖醛酸钠,D(+)-Glucuronic acid sodium salt monohydrate |
Others; Endogenous Metabolite | Metabolism; Others |
D-Glucuronic acid sodium salt monohydrate (Sodium D-glucuronate) 是内源性代谢产物的一种。 | |||
T3779 |
Crocin II
Crocin 2,西红花苷II,Crocetin gentiobiosylglucosyl ester,藏红花,Tricrocin,Crocin B |
Caspase; COX; NO Synthase | Apoptosis; Immunology/Inflammation; Neuroscience; Proteases/Proteasome |
Crocin II (Crocetin gentiobiosylglucosyl ester) 是从栀子果实中分离出来的一种天然产物,具有抗氧化、抗癌和抗抑郁活性。它抑制 iNOS 和 COX-2的蛋白质和 m-RNA 的表达,还抑制NO 产生,IC50值为 31.1 μM。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-02996 |
KsdD Protein, Mycobacterium smegmatis, Recombinant (His & Myc)
3-oxosteroid 1-dehydrogenase,3-keto-Delta(4)-steroid Delta(1... |
Mycolicibacterium smegmatis | E. coli |
Catalyzes the elimination of the C-1 and C-2 hydrogen atoms of the A-ring from the polycyclic ring structure of 3-ketosteroids. Is also involved in the formation of 1,4-androstadiene-3,17-dione (ADD) from 4-androstene-3,17-dione (AD) to. KsdD Protein, Mycobacterium smegmatis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 68.9 kDa and the accession number is A0R4S9. | |||
TMPK-00612 |
CSPG5 Protein, Mouse, Recombinant (His)
MGC44034,Chondroitin sulfate proteoglycan 5,Neuroglycan C,Ca... |
Mouse | HEK293 Cells |
CALEB also known as chondroitin sulfate proteoglycan (CSPG)5 or neuroglycan C, is a neural chondroitin sulfate-containing and epidermal growth factor (EGF)-domain-containing transmembrane protein that is implicated in synaptic maturation. An involvement of CALEB in the presynaptic differentiation of cerebellar GABAergic synapses and revealed a new role for CALEB in synapse elimination in Purkinje cells. | |||
TMPH-02195 |
TXNDC17 Protein, Human, Recombinant (GST)
Thioredoxin-like protein 5,Protein 42-9-9,Thioredoxin domain... |
Human | E. coli |
Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide. | |||
TMPH-03739 |
Alginate lyase Protein, Azotobacter vinelandii, Recombinant (His & Myc & SUMO)
Poly(beta-D-mannuronate) lyase,algL |
Azotobacter vinelandii | E. coli |
Catalyzes the depolymerization of alginate by cleaving the beta-1,4 glycosidic bond between two adjacent sugar residues via a beta-elimination mechanism. Splits ManA-ManA and ManA-GulA bonds, but not GulA-ManA or GulA-GulA bonds. Also cleaves acetylated residues. May serve to degrade mislocalized alginate that is trapped in the periplasmic space. | |||
TMPH-02615 |
CBS Protein, Mouse, Recombinant (His)
Cystathionine beta-synthase,Serine sulfhydrase,Beta-thionase... |
Mouse | E. coli |
Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons. | |||
TMPH-03183 |
Alginate lyase Protein, Pseudomonas fluorescens, Recombinant (His & Myc)
Poly(beta-D-mannuronate) lyase,algL |
Pseudomonas fluorescens | E. coli |
Catalyzes the depolymerization of alginate by cleaving the beta-1,4 glycosidic bond between two adjacent sugar residues via a beta-elimination mechanism. May serve to degrade mislocalized alginate that is trapped in the periplasmic space. Alginate lyase Protein, Pseudomonas fluorescens, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 47.1 kDa and the accession number is P59786. | |||
TMPH-01978 |
SFTPA1 Protein, Human, Recombinant (B2M & His & Myc)
Alveolar proteinosis protein,Pulmonary surfactant-associated... |
Human | E. coli |
In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages.; (Microbial infection) Recognition of M.tuberculosis by dendritic cells may occur partially via this molecule. Can recognize, bind, and opsonize pathogens to enhance their elimination by alveolar macrophages. SFTPA1 ... | |||
TMPJ-00788 |
UROD Protein, Human, Recombinant (His)
UPD,UROD,Uroporphyrinogen Decarboxylase,URO-D |
Human | E. coli |
Uroporphyrinogen decarboxylase (UROD), is an enzyme of the heme biosynthetic pathway which belongs to the uroporphyrinogen decarboxylase family. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. UROD is a homodimeric enzyme that catalyzes the fifth step in heme biosynthesis: the elimination of carboxyl groups from the four acetate side chains of uroporphyrinogen III to yield coproporphyrinogen... | |||
TMPH-01597 |
KYAT1 Protein, Human, Recombinant (His & SUMO)
Kynurenine aminotransferase 1,KYAT1,Glutamine--phenylpyruvat... |
Human | E. coli |
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. Also metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cl... | |||
TMPJ-00748 |
Ig kappa Protein, Human, Recombinant (His)
Ig κ chain C region AG,Ig κ,Ig kappa chain C region AG,Ig ka... |
Human | HEK293 Cells |
Immunoglobulin Kappa is constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humo... | |||
TMPJ-00614 |
CD47 Protein, Rhesus macaque, Recombinant (His & Flag)
MER6,Integrin-Associated Protein,IAP,Leukocyte Surface Antig... |
Rhesus | HEK293 Cells |
CD47, also known as Integrin‑Associated Protein (IAP) and OA3, is a glycosylated atypical member of the immunoglobulin superfamily. Mouse CD47 is an integral membrane protein that consists of a extracellular domain (ECD) with a single Ig‑like domain, five membrane-spanning regions with short intervening loops, and C‑terminal cytoplasmic tail. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. It plays an important r... | |||
TMPY-02552 |
Adenylosuccinate Lyase Protein, Human, Recombinant (His)
ASL,adenylosuccinate lyase,ASASE,AMPS |
Human | E. coli |
Adenylosuccinate lyase, also known as adenylosuccinase, ADSL or ASL, is an enzyme implicated in the reaction of adenylosuccinat converting to AMP and fumarate as part of the purine nucleotide cycle. The two substates of adenylosuccinate lyase (ADSL) are dephosphorylated derivatives of SAICA ribotide (SAICAR) and adenylosuccinate (S-AMP), which catalyzes an important reaction in the de novo pathway of purine biosynthesis. ADSL catalyzes two distinct reactions in the synthesis of purine nucleotide... | |||
TMPY-02798 |
NEIL1 Protein, Human, Recombinant (His)
NEI1,nei endonuclease VIII-like 1 (E. coli),FPG1,hFPG1 |
Human | E. coli |
NEIL1 is a member of DNA glycosylases. DNA glycosylases are a family homologous to the bacterial Fpg/Nei family. They play a role in base excision repair which is the mechanism by which damaged bases in DNA are removed and replaced. The first step of this process is catalyzed by DNA glycosylases. They remove the damaged nitrogenous base while leaving the sugar-phosphate backbone intact, creating an apurinic/apyrimidinic site, commonly referred to as an AP site. NEIL1 functions in base excision r... | |||
TMPY-03452 |
PTS Protein, Human, Recombinant (His)
PTPS,PTS,6-pyruvoyltetrahydropterin synthase |
Human | E. coli |
PTS(6-pyruvoyltetrahydropterin synthase) belongs to the PTPS family. It catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia.... | |||
TMPH-02314 |
XRCC5 Protein, Human, Recombinant (His & MBP)
Nuclear factor IV,Lupus Ku autoantigen protein p86,ATP-depen... |
Human | Baculovirus Insect Cells |
Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and bind... | |||
TMPH-02315 |
XRCC5 Protein, Human, Recombinant (His & Myc)
ATP-dependent DNA helicase 2 subunit 2,XRCC5,Ku86,Nuclear fa... |
Human | E. coli |
Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and bind... |