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Search Results for " dsrna "

Targets Recommended: Others

8

抑制剂 & 化合物

1

天然产物

14

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T16698	Pyronin Y C.I. 45005,派洛宁Y,派洛宁 Y,Pyronine G	Others	Others
	Pyronin Y (Pyronine G) 是一种可插入 RNA 的阳离子染料，可以靶向包括 RNA，DNA 和细胞器的细胞结构。它能够与双链核酸(尤其是 RNA) 形成荧光复合物，半定量分析细胞 RNA。它可用于活细胞中核糖核蛋白复合物的特定 RNA 亚种的鉴定。
T22698	TLR3-IN-1 CU CPT 4a	TLR	Immunology/Inflammation
	TLR3-IN-1 (CU CPT 4a) 是一种选择性的TLR3信号抑制剂，在 RAW 264.7 细胞中 IC50 为 3.44 μM。它可以抑制 TLR3/dsRNA 复合物介导的下游信号通路，并抑制全细胞中 TNF-α 和 IL-1β 的产生。
T12516	Polyinosinic-polycytidylic acid sodium 双链聚肌胞,Poly(I:C) sodium	Apoptosis; Others; TLR	Apoptosis; Immunology/Inflammation; Others
	Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) 是双链 RNA 的合成类似物，是TLR3和视黄酸诱导型基因 I 受体激动剂。它可以用作疫苗佐剂，直接触发癌细胞发生凋亡，还增强先天性和适应性免疫反应，并改变肿瘤的微环境。
T23171	Polyinosinic-polycytidylic acid Poly(I:C),聚胞苷酸	TLR	Immunology/Inflammation
	Polyinosinic-polycytidylic acid (Poly(I:C)) 是一种双链 RNA (dsRNA)，是一种 TLR3 激动剂。Polyinosinic-polycytidylic acid 可以诱导哺乳动物天然免疫。
T39802	Nedosiran DCR-PHXC	Others	Others
	Nedosiran (DCR-PHXC) is a GalNAc-dsRNA conjugate designed for RNA interference (RNAi) targeting lactate dehydrogenase (LDH). It serves as a potential therapeutic option for patients with primary hyperoxaluria (PH) and end-stage renal disease (ESRD).
T73994	Nedosiran sodium	Others	Others
	Nedosiran sodium 是一种靶向乳酸脱氢酶 (LDH)的 RNA 干扰剂 (RNAi)。Nedosiran sodium?可用于研究并发终末期肾病 (ESRD)的原发性高草酸尿症 (PH)。
T73674	Poly (I:C):Kanamycin (1:1)	Others	Others
	Poly (I:C):Kanamycin (1:1) 是一种 Poly (I:C) 与卡那霉素 (kanamycin) 以 1:1 比例混合得到的化合物。Poly (I:C) 为双链 RNA 的合成模拟物，充当 TLR3 受体的激动剂，而卡那霉素则能够增强 Poly (I:C) 的稳定性。
T38234	HCoV-229E-IN-1	Others	Others
	HCoV-229E-IN-1 is a potent inhibitor of HCoV-229E replication, with an EC50 of 0.65 μM and 0.6 μM in MTS and CPE cells, respectively[1]. HCoV-229E-IN-1 (compound 5h) (0.01-100 μM) fully suppresses the capacity of HCoV-229E replication in a dose-dependent manner[1].HCoV-229E-IN-1 (12 μM) fully prevented the formation of dsRNA intermediates of CoV RNA synthesis[1]. [1]. Stevaert A, et, al. Betulonic Acid Derivatives Interfering with Human Coronavirus 229E Replication via the nsp15 Endoribonuclease...

化合物

Cat.No: T16698

Synonym: C.I. 45005,派洛宁Y,派洛宁 Y,Pyronine G

Target: Others

Cat.No: T22698

Synonym: CU CPT 4a

Target: TLR

Polyinosinic-polycytidylic acid sodium

Cat.No: T12516

Synonym: 双链聚肌胞,Poly(I:C) sodium

Target: Apoptosis, Others, TLR

Polyinosinic-polycytidylic acid

Cat.No: T23171

Synonym: Poly(I:C),聚胞苷酸

Target: TLR

Cat.No: T39802

Synonym: DCR-PHXC

Target: Others

Nedosiran sodium

Cat.No: T73994

Target: Others

Poly (I:C):Kanamycin (1:1)

Cat.No: T73674

Target: Others

Cat.No: T38234

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T9113	Myristicin Myristicine,肉豆蔻醚	IL Receptor; Anti-infection; BCL; P450; PARP; 5-HT Receptor; Caspase; GABA Receptor; NO Synthase	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Myristicin (Myristicine) 是一种在香料和伞形植物中发现的天然产物。肉豆蔻素具有抗胆碱能、抗菌和肝保护作用，还具有抗炎作用，其通过钙途径抑制dsrna 刺激的巨噬细胞中的NO、细胞因子、趋化因子和生长因子。Myristicin 可以诱导细胞凋亡，其特征是改变线粒体膜电位、细胞色素c 释放、Caspase-3激活、parp 切割和DNA 断裂。

天然产物

Cat.No: T9113

Synonym: Myristicine,肉豆蔻醚

Target: IL Receptor, Anti-infection, BCL, P450, PARP, 5-HT Receptor, Caspase, GABA Receptor, NO Synthase

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02219	Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS1 Protein (His) NS1 Protein	H1N1	E. coli
	The NS1 Influenza protein is created by the internal protein-encoding, linear negative-sense, single-stranded RNA, NS gene segment and which also codes for the nuclear export protein or NEP, formerly referred to as the NS2 protein, which mediates the export of vRNPs. The non-structural (NS1) protein is found in Influenzavirus A, Influenzavirus B, and Influenzavirus C. The non-structural (NS1) protein of the highly pathogenic avian H5N1 viruses circulating in poultry and waterfowl in Southeast As...
TMPH-01902	DDX60 Protein, Human, Recombinant (His) Probable ATP-dependent RNA helicase DDX60,DEAD box protein 6...	Human	E. coli
	Positively regulates DDX58/RIG-I- and IFIH1/MDA5-dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of DDX58/RIG-I to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV). DDX60 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.1 kDa and the accession number is Q8IY2...
TMPH-02977	ZNF346 Protein, Mouse, Recombinant (His & SUMO) Just another zinc finger protein,Znf346,Zinc finger protein ...	Mouse	E. coli
	Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity. May bind to specific miRNA hairpins. ZNF346 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 48.7 kDa and the accession number is Q9R0B7.
TMPH-03404	Reovirus type 3 (strain Dearing) Outer capsid protein sigma-3 (His) S4,Outer capsid protein sigma-3	Reo-3	E. coli
	Stimulates translation by blocking the activation of the dsRNA-dependent protein kinase EIF2AK2/PKR, thereby inhibiting the host interferon response. Sigma3 prevents the activation of EIF2AK2 by competing with the kinase for dsRNA-binding.; The viral outer shell polypeptides, of which sigma-3 is one, impose structural constraints that prevent elongation of nascent transcripts by the RNA-dependent RNA polymerase lambda-3. Reovirus type 3 (strain Dearing) Outer capsid protein sigma-3 (His) is expr...
TMPH-03712	Clp1 Protein, Xenopus laevis, Recombinant (His) clp1,Pre-mRNA cleavage complex II protein Clp1,Polyadenylati...	Xenopus laevis	E. coli
	Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the...
TMPY-00323	Hepatitis C virus (HCV-1a) NS3 protease/helicase immunodominant region Protein (aa 1356-1459, GST) NS3	HCV	E. coli
	HCV NS3 displays three enzymatic activities: serine protease, NTPase, and RNA helicase. HCV NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A, and NS5A-NS5B. HCV NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction, and likely RNA stable secondary structure in the template strand (By similarity). Cleaves and inhibits the host antiviral protein MAVS. NS3/NS4A complex also prevents phosphorylation of human IRF3, t...
TMPJ-01429	SARS-CoV-2 Guanine-N7 methyltransferase Protein (His) SARS-CoV 2 nsp14,Guanine-N7 methyltransferase,SARS-CoV 2 Exo...	SARS-CoV-2	E. coli
	The nonstructural protein (nsp) 14 of SARS-CoV 2 was identified as a cap (guanine-N7)-methyltransferase (N7-MTase). Nsp14 of coronaviruses two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity. It may be involved in the proof-reading ability during the viral RNA replication and transcription. GTP, dGTP as well as cap analogs GpppG, GpppA and m7GpppG could be methylated by nsp14.
TMPH-01247	POLR3K Protein, Human, Recombinant (His) RNA polymerase III subunit C11,POLR3K,RNA polymerase III 12....	Human	Baculovirus Insect Cells
	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase I...
TMPH-03733	Zaire ebolavirus (strain Kikwit-95) VP35 Protein (His & Myc) Polymerase cofactor VP35,VP35,Ebola VP35	ZEBOV	HEK293 Cells
	Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/NP monomer chaperone prior to the formation of the large oligomeric RNA-bound complexes. Regulates RNA synthesis by modulating NP-RNA interactions and interacting with DYNLL1. VP35-NP interaction controls the switch between RNA-bound NP and free NP and thus the switch between gen...
TMPH-03732	Zaire ebolavirus (strain Kikwit-95) VP35 Protein (E. col, His & Myc) Polymerase cofactor VP35,Ebola VP35,VP35	ZEBOV	E. coli
	Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/NP monomer chaperone prior to the formation of the large oligomeric RNA-bound complexes. Regulates RNA synthesis by modulating NP-RNA interactions and interacting with DYNLL1. VP35-NP interaction controls the switch between RNA-bound NP and free NP and thus the switch between gen...
TMPJ-01427	SARS-CoV-2 NSP7 Protein (His) SARS-CoV 2 nsp7	SARS-CoV-2	E. coli
	The ∼30kb positive-stranded RNA genome of coronaviruses encodes a replication/transcription machinery that is unusually complex and composed of 16 nonstructural proteins (nsps). The four proteins nsp7 to nsp10, which are conserved among all CoVs but have no functional homologs outside of the Coronaviridae, are translated as part of the viral polyproteins pp1a and pp1ab, and the mature proteins are released by the action of the SARS-CoV protease nsp5. Hexadecamer of nsp7 and nsp8 may possess dsRN...
TMPH-01246	POLR3A Protein, Human, Recombinant (His) RNA polymerase III subunit C160,RNA polymerase III 155 kDa s...	Human	E. coli
	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft ...
TMPH-02133	DDX39B Protein, Human, Recombinant (GST) UAP56,HLA-B-associated transcript 1 protein,DDX39B,ATP-depen...	Human	E. coli
	Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it fun...
TMPH-01248	ADAR Protein, Human, Recombinant (His & SUMO) ADAR1,IFI-4,136 kDa double-stranded RNA-binding protein,Inte...	Human	E. coli
	Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences duri...

重组蛋白

Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS1 Protein (His)

Cat.No: TMPY-02219

Species: H1N1

Expression System: E. coli

DDX60 Protein, Human, Recombinant (His)

Cat.No: TMPH-01902

Species: Human

Expression System: E. coli

ZNF346 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02977

Species: Mouse

Expression System: E. coli

Reovirus type 3 (strain Dearing) Outer capsid protein sigma-3 (His)

Cat.No: TMPH-03404

Species: Reo-3

Expression System: E. coli

Clp1 Protein, Xenopus laevis, Recombinant (His)

Cat.No: TMPH-03712

Species: Xenopus laevis

Expression System: E. coli

Hepatitis C virus (HCV-1a) NS3 protease/helicase immunodominant region Protein (aa 1356-1459, GST)

Cat.No: TMPY-00323

Species: HCV

Expression System: E. coli

SARS-CoV-2 Guanine-N7 methyltransferase Protein (His)

Cat.No: TMPJ-01429

Species: SARS-CoV-2

Expression System: E. coli

POLR3K Protein, Human, Recombinant (His)

Cat.No: TMPH-01247

Species: Human

Expression System: Baculovirus Insect Cells

Zaire ebolavirus (strain Kikwit-95) VP35 Protein (His & Myc)

Cat.No: TMPH-03733

Species: ZEBOV

Expression System: HEK293 Cells

Zaire ebolavirus (strain Kikwit-95) VP35 Protein (E. col, His & Myc)

Cat.No: TMPH-03732

Species: ZEBOV

Expression System: E. coli

SARS-CoV-2 NSP7 Protein (His)

Cat.No: TMPJ-01427

Species: SARS-CoV-2

Expression System: E. coli

POLR3A Protein, Human, Recombinant (His)

Cat.No: TMPH-01246

Species: Human

Expression System: E. coli

DDX39B Protein, Human, Recombinant (GST)

Cat.No: TMPH-02133

Species: Human

Expression System: E. coli

ADAR Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01248

Species: Human

Expression System: E. coli

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