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Search Results for " disease (ad) "

Targets Recommended: Calcium Channel Sodium Channel Carbonic Anhydrase

102

抑制剂 & 化合物

17

天然产物

3

化合物库

18

重组蛋白

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同位素标记化合物

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Cat. No.	Product Name
L9840	抗阿尔茨海默症化合物库		986 compounds
	986 种阿尔茨海默症相关的化合物集合，可用于高通量和高内涵筛选；
L2620	神经退行性疾病化合物库		2154 compounds
	2154 种与神经退行性疾病相关的化合物，可用于高通量和高内涵筛选；
L1310	细胞骨架化合物库		759 compounds
	759 种细胞骨架相关的化合物，可以用于高通量和高内涵筛选；

化合物库

抗阿尔茨海默症化合物库

Cat.No: L9840

Compounds: 986

神经退行性疾病化合物库

Cat.No: L2620

Compounds: 2154

细胞骨架化合物库

Cat.No: L1310

Compounds: 759

Cat. No.	Product Name	Target	Signaling Pathways
T0267	Zonisamide AD 810,唑尼沙胺,CI 912	Calcium Channel; Sodium Channel; Carbonic Anhydrase	Membrane transporter/Ion channel; Metabolism
	Zonisamide (AD 810) 是锌酶碳酸酐酶 (carbonic anhydrase) 的有效抑制剂，对人类线粒体同工酶 hCA II 和 hCA V 作用的 Ki 值分别为 35.2 nM 和 20.6 nM。Zonisamide 具有抗癫痫活性，在癫痫、癫痫发作和帕金森病的研究中具有价值。
T28750	Sembragiline RG-1577,EVT-302,RO-4602522,RO4602522,RG1577,EVT302	MAO	Metabolism; Neuroscience
	Sembragiline (EVT-302) 是一种具有选择性的 MAO-B 抑制剂，可用于研究阿尔茨海默病（AD）。
T28441	PPI-1019 PPI1019,Apan	Beta Amyloid	Neuroscience
	PPI-1019 是一种 APP( β -淀粉状蛋白 A4 )抑制剂，可用于治疗神经系统疾病和研究阿尔茨海默病（AD）。
T21956	GSK3β inhibitor II	GSK-3	PI3K/Akt/mTOR signaling; Stem Cells
	GSK3β inhibitor II 是 GSK3β 的抑制剂。GSK3β inhibitor II 可用于研究阿尔茨海默病 (AD)。
TP1140L	Neuropeptide Y (29-64), amide, human acetate	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Neuropeptide Y (29-64), amide, human acetate 参与阿尔茨海默病 (AD) 并保护大鼠皮质神经元免受 β-淀粉样蛋白毒性。
T9379	L-Threonic acid magnesium salt	Others	Others
	L-Threonic acid magnesium salt 可增加老年大鼠和晚期阿尔茨海默病 (AD) 模型小鼠的突触密度和记忆能力。
T8448	ZSET1446 ZSET-1446,ST-101	Calcium Channel; AChR	Membrane transporter/Ion channel; Metabolism; Neuroscience
	ZSET1446 (ST-101) 是一种 T 型钙通道激活剂，用于治疗各类阿尔茨海默病 (AD) 模型中的学习缺陷。
T8583	Tenilsetam 替尼西坦,3-(2-thienyl)- (9CI),Piperazinone	Others	Others
	Tenilsetam (Piperazinone) 是一种核酸内切酶调节剂；一种促智剂和晚期糖基化终产物 (AGE) 抑制剂，具有治疗阿尔茨海默病 (AD) 的潜力。
TP2194L	Neuropeptide Y (scrambled) Acetate Pro-Neuropeptide Y (scrambled) Acetate,NPY (scrambled) Acetate	Others	Others
	Neuropeptide Y (scrambled) Acetate (Pro-Neuropeptide Y (scrambled) Acetate) 是一种 Neuropeptide Y 的杂序肽，Neuropeptide Y 参与阿尔茨海默病 (AD) ，可能具有神经保护作用。
T77054	Lecanemab BAN-2401	Beta Amyloid	Neuroscience
	Lecanemab (BAN-2401) 是一种靶向可溶性聚集性 β 淀粉样蛋白（Abeta）的 IgG1 单克隆抗体，对寡聚体、原纤维和不溶性原纤维具有活性，可用于研究阿尔茨海默病（AD）引起的轻度认知障碍和轻度 AD 痴呆。
T2507	Azeliragon TTP488,阿齐瑞格	Beta Amyloid; advanced glycation end products	Neuroscience; Others
	Azeliragon (TTP488) 是一种生物可利用的、可穿过血脑屏障 (BBB)的晚期糖基化终产物 (RAGE) 受体抑制剂，可缓解轻度阿尔茨海默病 (AD) 的发展。
T63540	Astrophloxine	Beta Amyloid	Neuroscience
	Astrophloxine 是能够靶向反平行二聚体的荧光成像探针。Astrophloxine 可用于检测阿尔茨海默症 (AD) 小鼠脑组织和脑脊液样本中聚集的Aβ。
T9062	CA77.1	Autophagy	Autophagy
	CA77.1 是一种新型伴侣介导的自噬激活剂，用于治疗阿尔茨海默病。它是 AR7 的衍生物，可以增加溶酶体受体在溶酶体中的表达。
T84317	AVN 322 free base	5-HT Receptor	GPCR/G Protein; Neuroscience
	AVN 322 free base 是一种可口服且具有选择性和高效性的 5-HT6R 拮抗剂，可用于研究阿尔茨海默病（AD）和精神分裂症等神经病理系统疾病。
T77042	Aducanumab BIIB037	Beta Amyloid	Neuroscience
	Aducanumab (BIIB037)，一种选择性人免疫球蛋白γ-1（IgG1）单克隆抗体，靶向β淀粉样蛋白 (Aβ) 的聚集形式。Aducanumab 显示出脑渗透性，可用于治疗阿尔茨海默病 (AD) 。
T60150	(1S,2R)-Alicapistat	Cysteine Protease	Proteases/Proteasome
	(1S,2R)-Alicapistat ((1S,2R)-ABT-957) is a highly efficient, orally active compound that selectively inhibits human calpains 1 and 2, with promising implications for Alzheimer's disease (AD) therapy [1]. This compound effectively addresses the metabolic liability associated with carbonyl reduction, while demonstrating potent inhibition of calpain 1 with an IC50 value of 395 nM [2].
T60739L	Y13g dihydrochloride Y13g 2HCl(T60739 Free base)	IL Receptor; AChE	Immunology/Inflammation; Neuroscience
	Y13g dihydrochloride 是白细胞介素 6 (IL-6) 和乙酰胆碱酯酶 (AChE)的有效抑制剂（这两个靶点阿尔茨海默症 (AD) 进展的有关）。Y13g dihydrochloride 逆转 STZ 诱导的记忆缺陷，并表现出与正常动物相似的组织病理学。
T7003	Leucomethylene blue mesylate N3,N3,N7,N7-四甲基-10H-吩噻嗪-3,7-二胺二甲磺酸盐,TRx0237 mesylate,TRx0237 (LMTX) mesylate,Methylene blue leuco base mesylate salt,Leucomethylene Blue Dimesylate	Beta Amyloid; Microtubule Associated	Cytoskeletal Signaling; Neuroscience
	Leucomethylene blue mesylate (TRx0237 mesylate) 是一种 Methylene blue (亚甲基蓝)的还原形式, 亚甲基蓝是一种化学指示剂和生物染色剂。它是一种具有口服活性的二代 tau 蛋白聚集的抑制剂 (Ki=为0.12 μM)，可用于阿尔兹海默症的研究。
T11175	Elenbecestat E2609	Beta-Secretase; BACE	Neuroscience
	Elenbecestat (E2609) 是一种高效、有口服活性的，能透过 CNS 的 BACE-1抑制剂，它有用于阿尔茨海默病 (AD) 的研究潜力。
T4364	Aftin-4 Aftin 4,Aftin4	Beta Amyloid; Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Aftin-4 是一种 β-淀粉样蛋白42(Aβ42) 的诱导剂。
T22243	Anserine L-鹅肌肽,L-Anserine	Endogenous Metabolite	Metabolism
	Anserine (L-Anserine) 是 Carnosine 的甲基化形式，是口服具有活性的天然二肽，存在于脊椎动物的骨骼肌。它不会被血清肌肽酶裂解，能够作为生化缓冲液，螯合剂，抗糖化剂和抗氧化剂。它能够改善阿尔茨海默氏病模型小鼠的记忆功能。
T31090	CRANAD-102 CRANAD 102	Others	Others
	CRANAD-102 is a probe for selectively detecting sAβ species in Alzheimer's disease (AD).
T14178	Alicapistat ABT-957	Others	Others
	Alicapistat (ABT-957) is a human calpains 1 and 2 inhibitor. It can potentially be used to treat Alzheimer's disease (AD).
T68950	Hepta-histidine	Others	Others
	Hepta-histidine is a novel inhibitor of Tau aggregation against Tau-related neurodegenerative diseases including Alzheimer's disease (AD).
T41102	BSc3094	Others	Others
	BSc3094 is a potent Tau aggregation inhibitor that demonstrates the potential for Alzheimer's disease (AD) research.
T36446	Neuropeptide Y (human) (TFA)
	Neuropeptide Y (human) TFA, a compound implicated in Alzheimer's disease (AD), exhibits protective effects against β-Amyloid toxicity in rat cortical neurons.
TP1673	β-Amyloid (11-22) β-Amyloid 11-22
	β-Amyloid (11-22) is a peptide fragment of β-Amyloid.Beta-amyloid peptide (Abeta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be the cause of Alzheimer’s Disease (AD). AD is the most common neurodegenerat
T84812	CNS-11	Others	Others
	CNS-11为一种能够分解tau原纤维的化学化合物，适用于阿尔茨海默病(AD)的研究。
T76738	Bapineuzumab
	Bapineuzumab，一种针对β-淀粉样蛋白(APP)的单克隆抗体，适用于阿尔茨海默病(AD)的研究。
T30266	AZD8926 AZD 8926,AZD-8926	Others	Others
	AZD8926 is a potent and selective inhibitor of GSK3β(glycogen synthase kinase-3β). AZD8926 is potential for treating Alzheimer’s disease (AD), schizophrenia, and chronic as well as acute neurodegenerative diseases.
T69872	TM-9	Others	Others
	TM-9 is a novel multi-function inhibitor for the treatment of Alzheimer's disease (AD). TM-9 exhibits potent and balanced inhibitory activities against ChE and MAO-B.
T80878	Vanutide cridificar PF 05236806,ACC-001
	Vanutide cridificar (ACC-001)是一种氨基末端Aβ1-7肽的偶联物，用于阿尔茨海默病(AD)的研究。
T39678	Multitarget AD inhibitor-1	Others	Others
	Multitarget AD inhibitor-1 is a reversible and selective inhibitor of butyrylcholinesterase (BuChE) with IC50 values of 7.22 μM and 1.55 μM for human BuChE (hBuChE) and equine serum BuChE (eqBuChE), respectively. Additionally, it exhibits inhibitory activity towards β-secretase (IC50 value of 41.60 μM), amyloid β aggregation (IC50 value of 3.09 μM), and tau aggregation. As a diphenylpropylamine derivative, Multitarget AD inhibitor-1 holds promise for research pertaining to the multifunctional, d...
T79752	DDC 2′,3′-O-disulfate	Others	Others
	DDC 2′,3′-O-disulfate (compound 4) 可防止Aβ42纤维化和寡聚化，显示出在阿尔茨海默病（AD）研究中的应用潜力。
T61408	BChE-IN-2	Others	Others
	BChE-IN-2 (compound 22) is a highly effective inhibitor of BChE, exhibiting a Ki value of 0.099 μM. This compound represents a promising pyrimidine and pyridine derivative for investigating Alzheimer's disease (AD). [1]
T30876	CHF 2819 Ganstigmine HCl,CHF-2819,Ganstigmine hydrochloride,CHF2819	Others	Others
	CHF 2819 is a novel orally active acetylcholinesterase inhibitor (AChE) developed for the treatment of Alzheimer's disease (AD). CHF 2819 is a selective inhibitor of AChE, it is 115 times more potent against this enzyme than against butyrylcholinesterase (BuChE).
T68257	Hydromethylthionine HBr	Others	Others
	Hydromethylthionine, also known as LMTM and Leucomethylene Blue, is a apotent tau aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. Hydromethylthionine showed pharmacological activity on brain structure and function as both monotherapy and as an add-on to symptomatic treatment in certain patients with Alzheimer’s disease.
T73495	q-FTAA	Others	Others
	q-FTAA 与 Aβ1-42 原纤维结合，对 Aβ1-42 原纤维和阿尔茨海默病 PIB 结合复合物 (ADPBC) 的 EC50值分别为 330-630，300-500 nM。q-FTAA 具有研究阿尔茨海默病 (AD) 的潜力。
T80118	α-Synuclein (61-95) (human)
	α-Synuclein(61-95) (human) 是 α-Synuclein 的疏水核心区段，具有诱导神经元死亡的能力。该肽段在神经退行性疾病的研究中有应用，涉及阿尔茨海默病 (AD) 与帕金森病 (PD)。
T77028	Gosuranemab
	Gosuranemab (BMS-986168) 是一种人源化 IgG4抗tau 单克隆抗体。Gosuranemab 与人 N 端 tau 残基 15-22 结合。Gosuranemab 具有用于阿尔茨海默病 (AD) 研究的潜力。
T80700	β Amyloid(17-28) human
	β Amyloid(17-28) human 为β-淀粉样肽(Abeta)的一段核心片段，其结构受脂质诱导。本化合物能够促进β Amyloid40全长肽段的聚集，导致阿尔茨海默病(AD)中具毒性的聚集体形成。
T79011	TrkB-IN-1	Trk receptor	Tyrosine Kinase/Adaptors
	TrkB-IN-1为一种有效的口服活性TrkB激动剂，展现出优良的药代动力学特性。该化合物能够逆转AD模型小鼠的认知功能缺陷，适用于阿尔茨海默病的研究。
T76926	Bepranemab
	Bepranemab (UCB 0107)为人源化全长IgG4单克隆抗体，特异性结合中央tau表位（氨基酸235-250）。该化合物适用于阿尔茨海默病(AD)研究。
T79010	Lp-PLA2-IN-12	Phospholipase	Metabolism
	Lp-PLA2-IN-12（compound 19）为一种Lp-PLA2抑制剂，主要应用于神经退行性疾病（如AD、青光眼、AMD）及心血管疾病（诸如动脉粥样硬化）的研究。
T35892	Q134R Q134R	Others	Others
	Q134R, a neuroprotective hydroxyquinoline derivative that suppresses nuclear factor of activated T cell (NFAT) signaling. Q134R can across blood-brain barrier. Q134R has the potential for Alzheimer’s disease (AD) and aging-related disorders research[1]. Q134R (1-10 μM) suppresses NFAT signaling, without inhibiting calcineurin activity. Q134R partially inhibits NFAT activity in primary rat astrocytes, but does not prevent calcineurin-mediated dephosphorylation of a non-NFAT target, either in vivo...
TP1338	Neuropeptide Y (29-64), amide, human TFA
	Neuropeptide Y (29-64), amide, human (TFA) is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.It is showed that Neuropeptide Y (29-64), amide, human (TFA) is able to protect cortical neurons from Aβ25-35 t
T61785	BChE-IN-6	Others	Others
	BChE-IN-6 (compound 12) is a highly effective inhibitor of BChE, showcasing a Ki value of 0.182 μM. Notably, BChE-IN-6 exhibits significant chelating abilities towards Zn 2+. Due to these characteristics, BChE-IN-6 serves as a valuable tool for researchers in the field of Alzheimer's disease (AD) [1].
T62728	AChE-IN-24	Others	Others
	AChE-IN-24 是一种有效的、能透过血脑屏障的 AChE 抑制剂。AChE-IN-24 可以较强的抑制 hAChE (IC50: 0.053 μM)。AChE-IN-24 能够用于研究阿尔茨海默病 (AD)。
T76395	(Met(O)35)-Amyloid β-Protein (1-42)
	'(Met(O)35)-Amyloid β-Protein (1-42)，Aβ42的一种氧化形态，位于Met35。该化合物可形成与Aβ40具有相似大小和分布特征的寡聚体，适用于阿尔茨海默病（AD）研究。'
TP1228	β-Amyloid (1-16) Amyloid β-Protein (1-16),β-Amyloid 1-16
	β-Amyloid (1-16) is an amyloidogenic protein fragment with a sequence derived from β-amyloid. It exhibits the ability to bind to metal ions, indicating its involvement in metal-binding processes. β-Amyloid, a peptide, is responsible for the formation of amyloid plaques in the brains of individuals affected by Alzheimer's disease (AD).

化合物

Cat.No: T0267

Synonym: AD 810,唑尼沙胺,CI 912

Target: Calcium Channel, Sodium Channel, Carbonic Anhydrase

Cat.No: T28750

Synonym: RG-1577,EVT-302,RO-4602522,RO4602522,RG1577,EVT302

Target: MAO

Cat.No: T28441

Synonym: PPI1019,Apan

Target: Beta Amyloid

GSK3β inhibitor II

Cat.No: T21956

Target: GSK-3

Neuropeptide Y (29-64), amide, human acetate

Cat.No: TP1140L

Target: Neuropeptide Y Receptor

L-Threonic acid magnesium salt

Cat.No: T9379

Target: Others

Cat.No: T8448

Synonym: ZSET-1446,ST-101

Target: Calcium Channel, AChR

Cat.No: T8583

Synonym: 替尼西坦,3-(2-thienyl)- (9CI),Piperazinone

Target: Others

Neuropeptide Y (scrambled) Acetate

Cat.No: TP2194L

Synonym: Pro-Neuropeptide Y (scrambled) Acetate,NPY (scrambled) Acetate

Target: Others

Cat.No: T77054

Synonym: BAN-2401

Target: Beta Amyloid

Cat.No: T2507

Synonym: TTP488,阿齐瑞格

Target: Beta Amyloid, advanced glycation end products

Cat.No: T63540

Target: Beta Amyloid

Cat.No: T9062

Target: Autophagy

AVN 322 free base

Cat.No: T84317

Target: 5-HT Receptor

Cat.No: T77042

Synonym: BIIB037

Target: Beta Amyloid

(1S,2R)-Alicapistat

Cat.No: T60150

Target: Cysteine Protease

Y13g dihydrochloride

Cat.No: T60739L

Synonym: Y13g 2HCl(T60739 Free base)

Target: IL Receptor, AChE

Leucomethylene blue mesylate

Cat.No: T7003

Synonym: N3,N3,N7,N7-四甲基-10H-吩噻嗪-3,7-二胺二甲磺酸盐,TRx0237 mesylate,TRx0237 (LMTX) mesylate,Methylene blue leuco base mesylate salt,Leucomethylene Blue Dimesylate

Target: Beta Amyloid, Microtubule Associated

Cat.No: T11175

Synonym: E2609

Target: Beta-Secretase, BACE

Cat.No: T4364

Synonym: Aftin 4,Aftin4

Target: Beta Amyloid, Gamma-secretase

Cat.No: T22243

Synonym: L-鹅肌肽,L-Anserine

Target: Endogenous Metabolite

Cat.No: T31090

Synonym: CRANAD 102

Target: Others

Cat.No: T14178

Synonym: ABT-957

Target: Others

Hepta-histidine

Cat.No: T68950

Target: Others

Cat.No: T41102

Target: Others

Neuropeptide Y (human) (TFA)

Cat.No: T36446

β-Amyloid (11-22)

Cat.No: TP1673

Synonym: β-Amyloid 11-22

Cat.No: T84812

Target: Others

Cat.No: T76738

Cat.No: T30266

Synonym: AZD 8926,AZD-8926

Target: Others

Cat.No: T69872

Target: Others

Vanutide cridificar

Cat.No: T80878

Synonym: PF 05236806,ACC-001

Multitarget AD inhibitor-1

Cat.No: T39678

Target: Others

DDC 2′,3′-O-disulfate

Cat.No: T79752

Target: Others

Cat.No: T61408

Target: Others

Cat.No: T30876

Synonym: Ganstigmine HCl,CHF-2819,Ganstigmine hydrochloride,CHF2819

Target: Others

Hydromethylthionine HBr

Cat.No: T68257

Target: Others

Cat.No: T73495

Target: Others

α-Synuclein (61-95) (human)

Cat.No: T80118

Cat.No: T77028

β Amyloid(17-28) human

Cat.No: T80700

Cat.No: T79011

Target: Trk receptor

Cat.No: T76926

Cat.No: T79010

Target: Phospholipase

Cat.No: T35892

Synonym: Q134R

Target: Others

Neuropeptide Y (29-64), amide, human TFA

Cat.No: TP1338

Cat.No: T61785

Target: Others

Cat.No: T62728

Target: Others

(Met(O)35)-Amyloid β-Protein (1-42)

Cat.No: T76395

β-Amyloid (1-16)

Cat.No: TP1228

Synonym: Amyloid β-Protein (1-16),β-Amyloid 1-16

Cat. No.	Product Name	Target	Signaling Pathways
T0086	Galanthamine hydrobromide Galantamine hydrobromide,Galanthamine HBr,氢溴酸加兰他敏	AChR; AChE	Neuroscience
	Galanthamine hydrobromide (Galantamine hydrobromide) 是一种长效的中枢活性 AChE 抑制剂，IC50为 410 nM。它是神经元烟碱型 ACh 受体的变构增强剂，IC50值为 0.35 µM，可用于阿尔茨海默症的研究。
TN1341	8-Deoxygartanin 8-脱氧藤黄苷	Beta Amyloid; NF-κB; Parasite	Microbiology/Virology; Neuroscience; NF-κB
	8-Deoxygartanin 是山竹果中的异戊烯化呫吨酮。它是丁基胆碱酯酶选择性抑制剂，对阿尔茨海默病 (AD) 具有多功能活性，可能是有希望治疗 AD 的化合物。
T4955	saponaretin Isovitexin,Apigenin-6-C-glucoside,异牧荆素	Apoptosis; Antioxidant	Apoptosis; oxidation-reduction
	saponaretin 是许多中药的活性成分，具有多种活性，如抗氧化、抗炎、抗阿尔茨海默病（AD）作用等。
TN1472	Cassiaside	Beta-Secretase; BACE	Neuroscience
	Cassiaside 是一种萘甲酮糖苷，抑制 BACE1 (IC50= 4.45 μM; Ki=9.85 μM)。Cassiaside 对半乳糖胺损伤具有明显的肝脏保护作用，具有潜在的抗阿尔茨海默病 (AD) 活性。
TN1725	Hederacolchiside E 革叶常春藤皂苷E	Beta Amyloid; ROS	Immunology/Inflammation; Neuroscience
	Hederacolchiside E 具有抗氧化活性，并通过调节氧化应激在阿尔茨海默病 (AD) 模型中显示神经保护作用。 Hederacolchiside E 对亚油酸乳液的脂质过氧化具有抑制作用。 Hederacolchiside E 可能通过阻断缓激肽或其他炎症介质发挥其抗炎作用。
T3026	(-)-Huperzine A HupA,石杉碱,Huperzine A,石杉碱甲	Apoptosis; AChR; AChE; iGluR	Apoptosis; Membrane transporter/Ion channel; Neuroscience
	(-)-Huperzine A (HupA) 是从中国梅花苔中分离得到的一种生物碱，具有神经保护活性。它是高特异性可逆的，具有血脑屏障渗透性的一种乙酰胆碱酯酶抑制剂，其IC50值为 82 nM。它也是 N-甲基-D-天冬氨酸受体的非竞争性拮抗剂，可研究神经退行性疾病，如阿尔茨海默病。
T3392	Sinapine thiocyanate	P-gp; AChE	Membrane transporter/Ion channel; Neuroscience
	Sinapine thiocyanate 是萝卜中分离出来的一种生物碱，具有抗炎、抗氧化、抗肿瘤、抗血管生成和放射防护作用。它还是乙酰胆碱酯酶抑制剂，可用于研究阿尔茨海默症，共济失调，重症肌无力和帕金森氏病。
T4881	Phosphorylethanolamine O-Phosphorylethanolamine,乙醇胺磷酸酯	Others; Endogenous Metabolite	Metabolism; Others
	Phosphorylethanolamine (O-Phosphorylethanolamine) 是磷脂代谢的一种磷酸单酯代谢物。Phosphorylethanolamine 是磷脂合成的前体，也是磷脂分解的产物。与其他器官相比，大脑中磷酸单酯的含量要高得多。在大脑发育过程中，磷单酯通常在神经增生期间升高。这也与大脑发育过程中正常的程序性细胞死亡和突触修剪的发生相吻合。这些发现与磷酸单酯在膜生物合成中的作用是一致的。Phosphorylethanolamine 与抑制性神经递质GABA和GABAB受体部分激动剂 3-氨基丙基膦酸具有很强的结构相似性。Phosphorylethanolamine 是一种磷单酯，在阿尔茨海默病患者的大脑中减少。
TN1450	Brassicasterol 菜籽甾醇,油菜	Others	Others
	Brassicasterol may be a relevant additional biomarker in Alzheimer's disease (AD).
TN3218	7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one	Beta Amyloid; PI3K; mTOR	Neuroscience; PI3K/Akt/mTOR signaling
	7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may provide new insights on drug discovery of Alzheimer's disease (AD).
T75512	Bleformin A	Others	Others
	Bleformin A 是一种有效的BChE 抑制剂，其IC50值为 5.2 μM。Bleformin A 是可以从Bletilla striata 中分离得到的天然产物。Bleformin A 可用于研究阿尔茨海默病 (AD)。
T75511	BChE-IN-10	Others	Others
	BChE-IN-10 (compound 6)，一种从白芨 (Bletilla striata) 分离提取的丁酰胆碱酯酶 (BChE) 混合型抑制剂，具有 6.4 μM 的IC50，适用于阿尔兹海默症 (AD) 研究。
T75514	Blestrin D	Others	Others
	Blestrin D，作为一种丁酰胆碱酯酶(BChE)的有效混合型抑制剂，具有8.1 μM的IC50值，可从白芨(Bletilla striata)中分离提取，适用于阿尔兹海默症(AD)研究。
T73202	BChE-IN-11	Others	Others
	BChE-IN-11 是一种有效的、选择性的、非竞争性BChE(丁基胆碱酯酶)抑制剂，其IC50为 2.1 μM。BChE-IN-11 可用于阿尔茨海默病 (AD) 的研究。
T75513	BChE-IN-12	Others	Others
	BChE-IN-12 (compound 12) 为一种高效BChE非竞争性抑制剂，其IC50值为2.3 μM。该化合物可从白芨(Bletilla striata)中分离提取，适用于阿尔兹海默症(AD)的研究。
T75628	Methyl ganoderate A acetonide	Others	Others
	Methyl ganoderate A acetonide，羊毛甾烷三萜类化合物，是一种可从灵芝子实体中分离得到天然产物。Methyl ganoderate A acetonide 是一种有效的 AChE 抑制剂，IC50值为 18.35 μM。Methyl ganoderate A acetonide 可用于阿尔茨海默病 (AD) 的研究。
T75544	AChE/BChE-IN-11	Others	Others
	AChE/BChE-IN-11 (compound 1) 是一种有效的 AChE 和 BChE 双重抑制剂，AChE 和BChE 的IC50值为分别为 70 和 71 μM。AChE/BChE-IN-11 是一种天然产物，可以从朝鲜蓟叶中分离得到。AChE/BChE-IN-11 可用于阿尔茨海默病 (AD) 研究。

天然产物

Galanthamine hydrobromide

Cat.No: T0086

Synonym: Galantamine hydrobromide,Galanthamine HBr,氢溴酸加兰他敏

Target: AChR, AChE

8-Deoxygartanin

Cat.No: TN1341

Synonym: 8-脱氧藤黄苷

Target: Beta Amyloid, NF-κB, Parasite

Cat.No: T4955

Synonym: Isovitexin,Apigenin-6-C-glucoside,异牧荆素

Target: Apoptosis, Antioxidant

Cat.No: TN1472

Target: Beta-Secretase, BACE

Hederacolchiside E

Cat.No: TN1725

Synonym: 革叶常春藤皂苷E

Target: Beta Amyloid, ROS

(-)-Huperzine A

Cat.No: T3026

Synonym: HupA,石杉碱,Huperzine A,石杉碱甲

Target: Apoptosis, AChR, AChE, iGluR

Sinapine thiocyanate

Cat.No: T3392

Target: P-gp, AChE

Phosphorylethanolamine

Cat.No: T4881

Synonym: O-Phosphorylethanolamine,乙醇胺磷酸酯

Target: Others, Endogenous Metabolite

Cat.No: TN1450

Synonym: 菜籽甾醇,油菜

Target: Others

7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one

Cat.No: TN3218

Target: Beta Amyloid, PI3K, mTOR

Cat.No: T75512

Target: Others

Cat.No: T75511

Target: Others

Cat.No: T75514

Target: Others

Cat.No: T73202

Target: Others

Cat.No: T75513

Target: Others

Methyl ganoderate A acetonide

Cat.No: T75628

Target: Others

AChE/BChE-IN-11

Cat.No: T75544

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04310	Apolipoprotein A-IV/APOA4 Protein, Human, Recombinant (His) apolipoprotein A-IV	Human	HEK293 Cells
	Apolipoprotein is genetically associated with the risk of Alzheimer's disease (AD). The APOA1, APOC3, and APOA4 genes are closely linked and located on human chromosome 11. There was a decreased trend for levels of APOA1, APOC3, and APOA4 in AD patients. CONCLUSION: Low levels of APOA1, APOC3, and APOA4 are associated with risk of AD. APOA1, APOC3, and APOA4 should be developed as combined drugs for the therapy of AD. SNP(single nucleotide polymorphisms)in APOA1and APOA4 genes influences atherog...
TMPY-03407	NQO1 Protein, Human, Recombinant (His) NAD(P)H dehydrogenase, quinone 1,NMORI,DIA4,QR1,NMO...	Human	E. coli
	NQO1 gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. NQO1 forms homodimers and reduces quinones to hydroquinones. NQO1's enzymatic activity prevents the one-electron reduction of quinones that results in the production of radical species. Mutations in the NQO1 gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered ex...
TMPK-00191	PILRA Protein, Mouse, Recombinant (hFc) PILR-α,FDF03,PILRA,PILR-alpha,PILRalpha,PILRα	Mouse	HEK293 Cells
	Alzheimer's disease (AD) is a neurodegenerative disease characterized by a progressive decline in cognitive performance; Mild Cognitive Impairment (MCI) is instead an objective decline in cognitive performance that does not reach pathology. Paired immunoglobulin-like type 2 receptor alpha (PILRA) is a cell surface inhibitory receptor that was recently suggested to be involved in AD pathogenesis. In particular, the arginine-to-glycine substitution in position 78 (R78, rs1859788) was shown to be p...
TMPK-01146	LGMN Protein, Human, Recombinant (His) AI746452,Legumain,LGMN1,Prsc1,AEP,LGMN,AU022324	Human	HEK293 Cells
	Recently, functional studies have demonstrated that legumain (LGMN) cleaves both amyloid β-protein precursor and tau, promoting senile plaques and formation of neurofibrillary tangles, which may play a crucial role in the pathogenesis of Alzheimer's disease (AD). In single-variant association analysis, none of the common variants in LGMN were statistically significant. In gene-based analysis, the LGMN gene also showed no association with AD.
TMPY-01303	Serpin A3 Protein, Human, Recombinant (His) ACT,GIG25,serpin peptidase inhibitor, clade A (alph...	Human	HEK293 Cells
	SerpinA3, also known as Alpha 1-antichymotrypsin (AACT), is a plasma alpha globulin glycoprotein, and is a member of serpin superfamily of the serine protease inhibitors consisting of at least 35 members. SerpinA3 has been demonstrated to inhibit the activity of certain serine proteases, such as cathepsin G found in neutrophils, and chymases present in mast cells, by inducing a major conformational rearrangement, and thus protects some tissues from damage caused by proteolytic enzymes. This enzy...
TMPY-03842	PRNP/Prion Protein Protein, Human, Recombinant (hFc) PrPc,GSS,p27-30,ASCR,AltPrP,PRIP,PrP33-35C,PrP,CD230,PrP27-3...	Human	HEK293 Cells
	Prion protein (PRNP) gene is well known for affecting mammal transmissible spongiform encephalopathies (TSE), and is also reported to regulate phenotypic traits (e.g. growth traits) in healthy ruminants. PRNP is fundamental in the pathogenesis of transmissible spongiform encephalopathies. Generally, PRNP gene is associated with prion diseases, whereas variants of the PRNP gene may also explain some cases of Alzheimer disease (AD) and frontotemporal dementia (FTD) in Caucasian populations.
TMPK-00763	Apolipoprotein E/APOE3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated APOE3,Apo-E,apolipo E,Apolipoprotein E,APOE	Human	HEK293 Cells
	Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). Apolipoprotein E/APOE3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated i...
TMPK-00588	Apolipoprotein E/APOE4 Protein, Human, Recombinant (hFc) Apolipoprotein E,Apo-E,apolipo E,APOE4,APOE	Human	HEK293 Cells
	Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). Apolipoprotein E/APOE4 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells w...
TMPK-00589	Apolipoprotein E/APOE4 Protein, Human, Recombinant (His) APOE,apolipo E,Apo-E,APOE4,Apolipoprotein E	Human	HEK293 Cells
	Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). Apolipoprotein E/APOE4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells w...
TMPK-00788	Apolipoprotein E/APOE Protein, Mouse, Recombinant (hFc) apolipo E,Apo-E,Apolipoprotein E,APOE	Mouse	HEK293 Cells
	Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). Apolipoprotein E/APOE Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells wi...
TMPK-00762	Apolipoprotein E/APOE3 Protein, Human, Recombinant (hFc) APOE,Apo-E,Apolipoprotein E,APOE3,apolipo E	Human	HEK293 Cells
	Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). Apolipoprotein E/APOE3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells w...
TMPY-03653	CTRL Protein, Human, Recombinant (His) CTRL1,chymotrypsin-like	Human	HEK293 Cells
	CTRL-1, also known as chymotrypsin-like protease, belongs to thepeptidase S1 family. CTRL-1 contains 1peptidase S1 domain. Its expression is increased in preeclampsia (PE). Placental-derived chymotrypsin-like protease is responsible for inducing endothelial inflammatory phenotypic changes possibly by upregulation of cell adhesion molecule expressions, activation of cellular protease, and induction of extracellular regulated kinase phosphorylation. Activated microglia have been observed in variou...
TMPJ-00782	Amyloid Precursor Protein, Human, Recombinant (hFc) Amyloid Precursor,Amyloid Precursor Protein 695,APP695	Human	HEK293 Cells
	Amyloid precursor protein (APP) is a type I membrane protein with several isoforms due to alternative splicing, performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Of the three major splice isoforms of APP (APP695, APP751, and APP770) APP695 is the predominant neuronal form from which Amyloid beta peptide and transcriptionally-active cleaved intracellular domain of APP (AICD) are preferentially generated by selective process...
TMPY-02393	Thimet Oligopeptidase/THOP1 Protein, Mouse, Recombinant (His) thimet oligopeptidase 1,EP24.15,AI131655,AI327041	Mouse	Baculovirus Insect Cells
	THOP1, also known as Thimet oligopeptidase 1, Thimet oligopeptidase, EC 3.4.24.15, or EP24.15, is a zinc(II) endopeptidase implicated in the processing of numerous physiological peptides. As an intracellular enzyme, highly expressed in the brain, kidneys and neuroendocrine tissue, THOP1 has been proposed to metabolize peptides within cells, thereby affecting antigen presentation and G protein-coupled receptor signal transduction. Its substrates is gonadotrophin-releasing hormone (GnRH), an impor...
TMPY-00519	Gastrokine 1 Protein, Human, Recombinant (His) UNQ489/PRO1005,CA11,foveolin,BRICD1,AMP18,gastrokine 1,FOV	Human	Baculovirus Insect Cells
	Gastrokine 1 (GKN1) belongs to the BRICHOS domain family and plays a major role in maintaining gastric mucosa integrity. GKN1 is highly expressed in gastric tissue and is secreted into the stomach but is not expressed in gastric cancer. GKN1-mediated inhibition of APP processing might represent a new approach for the prevention and therapy of Alzheimer's disease (AD). In the presence of GKN2, GKN1 loses its ability to decrease cell proliferation, induce apoptosis, and inhibit epigenetic alterati...
TMPY-00473	NRBF2 Protein, Human, Recombinant (His & GST) NRBF-2,nuclear receptor binding factor 2,COPR2,COPR1	Human	Baculovirus Insect Cells
	NRBF2 (Nuclear Receptor Binding Factor 2) is a Protein Coding gene. The encoded protein may modulate transcriptional activation by target nuclear receptors. It is widely expressed in the appendix, placenta, and other tissues. NRBF2/Atg38 has been identified as the fifth subunit of the macroautophagy/autophagy class III phosphatidylinositol 3-kinase (PtdIns3K) complex, along with ATG14/Barkor, BECN1/Vps30, PIK3R4/p150/Vps15, and PIK3C3/Vps34. NRBF2 is a critical molecular switch of PtdIns3K and a...
TMPY-02300	BIN1 Protein, Human, Recombinant (His) AMPHL,bridging integrator 1,AMPH2,SH3P9	Human	E. coli
	Amphiphysin 2, also named bridging integrator-1 (BIN1) or SH3P9, Amphiphysin2/BIN1 is a crescent-shaped N-BAR protein playing a key role in forming deeply invaginated tubes in muscle T-tubules, has been recently implicated in rare and common diseases affecting different tissues and physiological functions. BIN1 downregulation is linked to cancer progression and also correlates with ventricular cardiomyopathy and arrhythmia preceding heart failure. Increased BIN1 expression is linked to increased...
TMPY-02063	Alpha-2-macroglobulin Protein, Human, Recombinant (His) α-2-macroglobulin,FWP007,CPAMD5,A2MD,S863-7,alpha-2-macroglo...	Human	Baculovirus Insect Cells
	alpha-2-macroglobulin, also known as α2-macroglobulin (α2M and A2M), is an abundant protein of the plasma of vertebrates and members of several invertebrate phyla and functions as a broad-spectrum protease-binding protein. alpha-2-macroglobulin is produced by the liver, and is a major component of the alpha-2 band in protein electrophoresis. alpha-2-macroglobulin is a large plasma glycoprotein that has long been known as an irreversible inhibitor of a variety of proteinases. More recently, it ha...

重组蛋白

Apolipoprotein A-IV/APOA4 Protein, Human, Recombinant (His)

Cat.No: TMPY-04310

Species: Human

Expression System: HEK293 Cells

NQO1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03407

Species: Human

Expression System: E. coli

PILRA Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00191

Species: Mouse

Expression System: HEK293 Cells

LGMN Protein, Human, Recombinant (His)

Cat.No: TMPK-01146

Species: Human

Expression System: HEK293 Cells

Serpin A3 Protein, Human, Recombinant (His)

Cat.No: TMPY-01303

Species: Human

Expression System: HEK293 Cells

PRNP/Prion Protein Protein, Human, Recombinant (hFc)

Cat.No: TMPY-03842

Species: Human

Expression System: HEK293 Cells

Apolipoprotein E/APOE3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated

Cat.No: TMPK-00763

Species: Human

Expression System: HEK293 Cells

Apolipoprotein E/APOE4 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00588

Species: Human

Expression System: HEK293 Cells

Apolipoprotein E/APOE4 Protein, Human, Recombinant (His)

Cat.No: TMPK-00589

Species: Human

Expression System: HEK293 Cells

Apolipoprotein E/APOE Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00788

Species: Mouse

Expression System: HEK293 Cells

Apolipoprotein E/APOE3 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00762

Species: Human

Expression System: HEK293 Cells

CTRL Protein, Human, Recombinant (His)

Cat.No: TMPY-03653

Species: Human

Expression System: HEK293 Cells

Amyloid Precursor Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00782

Species: Human

Expression System: HEK293 Cells

Thimet Oligopeptidase/THOP1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02393

Species: Mouse

Expression System: Baculovirus Insect Cells

Gastrokine 1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00519

Species: Human

Expression System: Baculovirus Insect Cells

NRBF2 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-00473

Species: Human

Expression System: Baculovirus Insect Cells

BIN1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02300

Species: Human

Expression System: E. coli

Alpha-2-macroglobulin Protein, Human, Recombinant (His)

Cat.No: TMPY-02063

Species: Human

Expression System: Baculovirus Insect Cells

Cat. No.	Product Name	Target	Signaling Pathways
T37847	Zonisamide-13C2,15N Zonisamide-13C2,15N
	Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium...

同位素标记化合物

Zonisamide-13C2,15N

Cat.No: T37847

Synonym: Zonisamide-13C2,15N

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