首页工具

登录

搜索结果

Search Results for " degrader "

Targets Recommended: ERK

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T39727	ERα degrader-2	ERK	MAPK
	ERα degrader-2 是一种具有选择性和有效性的雌激素受体 (SERD)降解剂，具有抗癌活性，抑制 ERα，对雌激素受体降解的 EC50 值为 0.3 nM。ERα degrader-2 可用于预防和治疗 HER 阳性乳腺癌。
T13721	Homo-PROTAC cereblon degrader 1	Others; PROTACs	Others; PROTAC
	Homo-PROTAC cereblon degrader 1 (compound 15a) 是一种高效 cereblon 降解剂，对 IKZF1 和 IKZF3 的影响很小。
T13722	Homo-PROTAC pVHL30 degrader 1	Others; PROTACs	Others; PROTAC
	Homo-PROTAC pVHL30 degrader 1 是一种基于 PROTAC 的 pVHL30 降解剂。
T9236	WSB1 Degrader 1	Others; E1/E2/E3 Enzyme	Others; Ubiquitination
	WSB1 Degrader 1 是具有口服活性的 WSB1降解剂，具有抗癌活性。
T69753	HDAC6 degrader 9c	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	HDAC6 degrader 9c 是一种小分子组蛋白脱乙酰酶 6 （HDAC6）降解剂，可用于研究癌症或其他疾病。
T4207	(S,R,S)-AHPC hydrochloride VHL Ligand 1 hydrochloride,ULM-1,Protein degrader 1 hydrochloride	Others; Ligand for E3 Ligase	Others; PROTAC
	(S,R,S)-AHPC hydrochloride (Protein degrader 1 hydrochloride) 是基于 VH032 的 VHL 配体，可用于募集 von Hippel-Lindau (VHL) 蛋白。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子。
T40112	PROTAC PD-1/PD-L1 degrader-1	PD-1/PD-L1; PROTACs	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; PROTAC
	PROTAC PD-1/PD-L1 degrader-1 是一种降解 PD-L1 的 PROTAC，抑制 PD-1/PD-L1 相互作用（IC50：39.2 nM）。PROTAC PD-1/PD-L1 degrader-1 可恢复 Hep3B/OS-8/hPD-L1 和 CD3 T 细胞共培养模型中被抑制的免疫力，可通过溶酶体依赖性方式降低 PD-L1 的蛋白质含量。
T37329	PROTAC IDO1 Degrader-1 PROTAC IDO1 Degrader-1	PROTACs	PROTAC
	PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to CRBN E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC50=2.84 μM). PROTAC IDO1 Degrader-1 moderately improves the tumor-killing activity of H ER2 CAR-T cells[1]. PROTAC IDO1 Degrader-1 (compound 2c) (10 μM; 24 hours) notably decreases IDO1 level induced by IFN-γ[1].PROTAC IDO1 Degrader-1 and IFN-γ (5 ng/mL) are incubated with HeLa cells for 24...
T40072	PROTAC BRD4 Degrader-9 PROTAC BRD4 Degrader-9	Others	Others
	PROTAC BRD4 Degrader-9 (compound 8a) is a novel chemical compound consisting of ligands for von Hippel-Lindau and BRD4, connected by a PROTAC moiety. This compound can effectively degrade the BRD4 protein in PC3 prostate cancer cells. When conjugated with STEAP1 and CLL1 antibodies, PROTAC BRD4 Degrader-9 exhibits potent activity, with respective DC50 values of 0.86 nM and 7.6 nM.
T39902	PROTAC IRAK4 degrader-5 PROTAC IRAK4 degrader-5	Others	Others
	PROTAC IRAK4 degrader-5 is a Cereblon-based IRAK4 degrader.
T36242	PROTAC BRD4 Degrader-5 PROTAC BRD4 Degrader-5	PROTACs	PROTAC
	PROTAC BRD4 Degrader-5 is a PROTAC-based BRD4 degrader. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines[1].
T40073	PROTAC BRD4 Degrader-10 PROTAC BRD4 Degrader-10	PROTACs	PROTAC
	PROTAC BRD4 Degrader-10, also known as compound 8b, is a dual ligand-based PROTAC that combines ligands for von Hippel-Lindau and BRD4. To degrade the BRD4 protein in PC3 prostate cancer cells, PROTAC BRD4 Degrader-10 can be conjugated with STEAP1 and CLL1 antibodies, with respective DC 50 values of 1.3 nM and 18 nM.
T40074	PROTAC BRD4 Degrader-15 PROTAC BRD4 Degrader-15	Others	Others
	PROTAC BRD4 Degrader-15 is a chemical compound consisting of a PROteolysis TArgeting Chimera (PROTAC) linked to ligands specific to von Hippel-Lindau and BRD4. It exhibits an IC50 of 7.2 nM for BRD4 BD1 and 8.1 nM for BRD4 BD2. Additionally, PROTAC BRD4 Degrader-15 demonstrates potent degradation activity against the BRD4 protein in PC3 prostate cancer cells.
T40143	PROTAC CBP/P300 Degrader-1 PROTAC CBP/P300 Degrader-1	PROTACs	PROTAC
	PROTAC CBP/P300 Degrader-1 is an effective compound that degrades CBP/P300 in a potent manner. It significantly reduces cell viability in various cancer cell lines.
T39920	PROTAC IRAK4 degrader-3 PROTAC IRAK4 degrader-3	PROTACs	PROTAC
	PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau.
T36628	PROTAC BRD4 Degrader-8 PROTAC BRD4 Degrader-8	PROTACs	PROTAC
	PROTAC BRD4 Degrader-8 is a potent BRD4 inhibitor, with IC50s of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-8 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells[1]. PROTAC BRD4 Degrader-8 (compound 8; 6 days) inhibits the proliferation of PC3 prostate cancer cells, with an IC50 of 28 nM[1].PROTAC BRD4 Degrader-8 (4 h) suppresses MYC gene transcript in MV4-11 AML cells, with an IC50 of 11 nM[1].PROTAC BRD4 Degrader-8 (4 h) potently degra...
T39903	PROTAC IRAK4 degrader-6 PROTAC IRAK4 degrader-6	Others	Others
	PROTAC IRAK4 degrader-6 is a potent Cereblon-based compound designed to degrade interleukin-1 receptor-associated kinase 4 (IRAK4).
T39901	PROTAC IRAK4 degrader-4 PROTAC IRAK4 degrader-4	Others	Others
	PROTAC IRAK4 degrader-4 (US20190192668A1, compound I-127) is a Cereblon-based PROTAC specifically designed to target and degrade interleukin-1 receptor-associated kinase 4 (IRAK4).
T40250	SHP2 protein degrader-1 SHP2 protein degrader-1	Others	Others
	SHP2 protein degrader-1 is a highly efficient allosteric inhibitor targeting SHP2. It effectively induces degradation of SHP2 protein, resulting in cell apoptosis. This compound shows promising potential for studying diseases associated with SHP2.
T39996	PROTAC CDK9 degrader-4 PROTAC CDK9 degrader-4	Others	Others
	PROTAC CDK9 degrader-4 is a potent and efficacious chemical compound designed specifically to degrade CDK9, a protein involved in transcription regulation. This compound effectively targets and reduces the levels of CDK9, thereby modulating transcriptional activity.
T40075	PROTAC BRD4 Degrader-13 PROTAC BRD4 Degrader-13	Others	Others
	PROTAC BRD4 Degrader-13 (compound 9d) is a bioactive compound that functions as a proteolysis targeting chimera (PROTAC), linking ligands for von Hippel-Lindau and BRD4 proteins. In the context of PC3 prostate cancer cells, this compound effectively degrades the BRD4 protein through conjugation with STEAP1 and CLL1 antibodies. The degradation of BRD4 protein is achieved with remarkable potency, exhibiting a DC 50 of 0.025 nM and 6.0 nM when combined with STEAP1 and CLL1 antibodies, respectively.
T77518	BLK degrader 1	Others	Others

T36256	LC-2 LC 2,PROTAC KRASG12C Degrader-LC-2,LC2	PROTACs	PROTAC
	LC-2 (PROTAC KRASG12C Degrader-LC-2) 是一种新型基于von Hippel-Lindau的内源性 KRAS G12C 的 PROTAC 降解剂，DC50 在 0.25 和 0.76 μM 之间。LC-2 是一种与 MRTX849 共价结合 KRAS G12C 并招募 E3 连接酶 VH的 PROTAC，诱导 KRAS G12C 快速持续降解。LC-2 对纯合和杂合子 KRAS G12C 细胞系 MAPK 信号有抑制作用。
T8745	PROTAC BRAF-V600E degrader-1 Compound 23	Raf; PROTACs	MAPK; PROTAC
	PROTAC BRAF-V600E degrader-1 (Compound 23) 选择性地诱导 BRAF-V600E 的降解，而不是野生型 BRAF。
T39685	PCSK9 degrader 1	Others	Others
	PCSK9 degrader 1 is a selective proprotein convertase substilisin-like/kexin type 9 (PCSK9) degrader. PCSK9 degrader 1 does not affect PCSK9 function.
T74982	Akt3 degrader 1	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Akt3 degrader 1 是一种特异性 Akt3 降解剂，具有抗癌抗增殖活性，可抑制小鼠体内肿瘤的生长。Akt3 degrader 1 可用于研究非小细胞肺癌和胰腺癌。
T39837	PROTAC ERRα Degrader-3	PROTACs	PROTAC
	PROTAC ERRα Degrader-3 is a highly effective and selective von Hippel-Lindau-based ligand that efficiently degrades the ERRα protein. At a concentration of 30 nM, this compound exhibits a remarkable degradation capability, reducing the ERRα protein levels by >80%. Importantly, PROTAC ERRα Degrader-3 shows no activity against the ERRβ and ERRγ proteins.
T5439	BRD4 degrader AT1	Epigenetic Reader Domain; PROTACs	Chromatin/Epigenetic; PROTAC
	BRD4 degrader AT1 是基于 PROTAC 技术的高选择性 Brd4 降解剂，在细胞中对 Brd4BD2 的 Kd 为 44 nM。
T13845	PROTAC PARP1 degrader	Others	Others
	PROTAC PARP1 degrader is a degrader of PARP1 based on the PROTAC technology. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line (IC50 of 6.12 μM).
T36243	PROTAC RIPK degrader-6	PROTACs	PROTAC
	PROTAC RIPK degrader-6 (example 1) is a PROTAC designed for the targeted degradation of RIP Kinase, featuring a RIP2 kinase inhibitor connected through a linker to a cereblon binder[1].
T83652	Cyclin K degrader 1	Others	Others
	Cyclin K degrader 1 是 Cyclin K 降解剂。Cyclin K degrader 1是由AT-7519转变而来的降解剂，对 Cyclin K 降解活性较弱，但不会导致降解亲和力持续下降。
T39374	PROTAC BET Degrader-10	PROTACs	PROTAC
	PROTAC BET Degrader-10 (WO2017007612A1, example 37) is a highly efficient and selective small molecule compound designed to degrade BET protein BRD4. PROTAC BET Degrader-10 functions by utilizing specific ligands that connect Cereblon and BRD4, with a DC 50 value of 49 nM.
T18609	PROTAC ERRα Degrader-2	Others	Others
	PROTAC ERRα Degrader-2 is a compound consisting of an MDM2 ligand binding group, a linker, and an estrogen-related receptor alpha (ERRα) binding group. This compound is designed to specifically degrade estrogen-related receptor alpha (ERRα), acting as an ERRα degrader[1].
T5438	PROTAC CDK9 Degrader-1	CDK; PROTACs	Cell Cycle/Checkpoint; PROTAC
	PROTAC CDK9 Degrader-1 是一种选择性 CDK9 降解剂，是由Cereblon 配体和CDK 配体相连的PROTAC。
T12560	PROTAC BRD9 Degrader-1	Epigenetic Reader Domain; PROTACs	Chromatin/Epigenetic; PROTAC
	PROTAC BRD9 Degrader-1 is a lead PROTAC BRD9 chemical degrader with IC50 of 13.5 nM.
T18632	PROTAC MDM2 Degrader-2	Others; PROTACs	Others; PROTAC
	PROTAC MDM2 Degrader-2 is a compound designed utilizing PROTAC technology, functioning as a MDM2 degrader. Comprised of a highly potent inhibitor targeting MDM2, a linker, and the MDM2 ligand for E3 ubiquitin ligase, this compound facilitates the degradation of MDM2[1].
T18631	PROTAC MDM2 Degrader-1	Others; PROTACs	Others; PROTAC
	PROTAC MDM2 Degrader-1 is a chemical compound that utilizes PROTAC technology to degrade MDM2. This compound is comprised of a highly effective MDM2 inhibitor, a linker, and the MDM2 ligand for E3 ubiquitin ligase[1].
T18635	PROTAC RAR Degrader-1	Others; PROTACs	Others; PROTAC
	PROTAC RAR Degrader-1 comprises a cIAP1 ligand binding group, a linker and a RAR ligand binding group. PROTAC RAR Degrader-1 is an RAR degrader. Maximal RAR degradation at 30 μM concentration in HT1080 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1].
T18605	PROTAC ERα Degrader-2	Others; PROTACs	Others; PROTAC
	PROTAC ERα Degrader-2 comprises a cIAP1 ligand binding group, a linker and an estrogen receptor α (ERα) binding group. PROTAC ERα Degrader-2 is an ERα degrader. Maximal ERα degradation at 30 μM concentration in human mammary tumor MCF7 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1].
T12553	PROTAC EED degrader-1	Others; PROTACs	Others; PROTAC
	PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.
T13833	PROTAC BRD4 Degrader-1	Epigenetic Reader Domain; PROTACs	Chromatin/Epigenetic; PROTAC
	PROTAC BRD4 Degrader-1 is an efficacious degrader of BRD4(BRD4 BD1,IC50 of 41.8 nM).
T18634	PROTAC MDM2 Degrader-4	Others	Others
	PROTAC MDM2 Degrader-4 is a compound designed using PROTAC technology to degrade MDM2. It combines a powerful MDM2 inhibitor, a linker, and the MDM2 ligand for E3 ubiquitin ligase[1].
T13847	PROTAC SGK3 degrader-1 SGK3-PROTAC1	SGK; PROTACs	Metabolism; PROTAC
	PROTAC SGK3 degrader-1 (SGK3-PROTAC1) 是一种靶向 SGK3 且与 VH032 VHL 结合配体的 PROTAC 偶联物，可诱导内源性 SGK3 降解。PROTAC SGK3 degrader-1 可抑制GDC0941诱导的癌细胞增殖。
T13840	PROTAC FAK degrader 1	Others; PROTACs	Others; PROTAC
	PROTAC FAK degrader 1 is a selective and potent degrader of focal adhesion kinase (Fak) (IC50 of 6.5 nM).
T13835	PROTAC BRD4 Degrader-3	Epigenetic Reader Domain	Chromatin/Epigenetic
	PROTAC BRD4 Degrader-3 is an efficacious degrader of PROTAC BRD4.
T13834	PROTAC BRD4 Degrader-2	Epigenetic Reader Domain	Chromatin/Epigenetic
	PROTAC BRD4 Degrader-2 is an efficacious degrader of PROTAC BRD4(BRD4 BD1,IC50 of 14.2 nM).
T16667	PROTAC Sirt2 Degrader-1	Sirtuin; PROTACs	Chromatin/Epigenetic; DNA Damage/DNA Repair; PROTAC
	PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s > 100 μM)[1].
T11975	PROTAC Mcl1 degrader-1	BCL; PROTACs	Apoptosis; PROTAC
	PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity. PROTAC Mcl1 degrader-1, a proteolysis targeting chimera (PROTAC), is a potently and selectively Mcl-1 inhibitor with an IC50 of 0.78 μM.
T17728	PROTAC CDK9 degrader-2	Others	Others
	PROTAC CDK9 degrader-2 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form PROTAC[1].
T10485	PROTAC Bcl2 degrader-1	BCL; PROTACs	Apoptosis; PROTAC
	PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 μM) and Bcl-2 (IC50: 4.94 μM; DC50: 3.0 μM).

化合物

ERα degrader-2

Cat.No: T39727

Target: ERK

Homo-PROTAC cereblon degrader 1

Cat.No: T13721

Target: Others, PROTACs

Homo-PROTAC pVHL30 degrader 1

Cat.No: T13722

Target: Others, PROTACs

WSB1 Degrader 1

Cat.No: T9236

Target: Others, E1/E2/E3 Enzyme

HDAC6 degrader 9c

Cat.No: T69753

Target: HDAC

(S,R,S)-AHPC hydrochloride

Cat.No: T4207

Synonym: VHL Ligand 1 hydrochloride,ULM-1,Protein degrader 1 hydrochloride

Target: Others, Ligand for E3 Ligase

PROTAC PD-1/PD-L1 degrader-1

Cat.No: T40112

Target: PD-1/PD-L1, PROTACs

PROTAC IDO1 Degrader-1

Cat.No: T37329

Synonym: PROTAC IDO1 Degrader-1

Target: PROTACs

PROTAC BRD4 Degrader-9

Cat.No: T40072

Synonym: PROTAC BRD4 Degrader-9

Target: Others

PROTAC IRAK4 degrader-5

Cat.No: T39902

Synonym: PROTAC IRAK4 degrader-5

Target: Others

PROTAC BRD4 Degrader-5

Cat.No: T36242

Synonym: PROTAC BRD4 Degrader-5

Target: PROTACs

PROTAC BRD4 Degrader-10

Cat.No: T40073

Synonym: PROTAC BRD4 Degrader-10

Target: PROTACs

PROTAC BRD4 Degrader-15

Cat.No: T40074

Synonym: PROTAC BRD4 Degrader-15

Target: Others

PROTAC CBP/P300 Degrader-1

Cat.No: T40143

Synonym: PROTAC CBP/P300 Degrader-1

Target: PROTACs

PROTAC IRAK4 degrader-3

Cat.No: T39920

Synonym: PROTAC IRAK4 degrader-3

Target: PROTACs

PROTAC BRD4 Degrader-8

Cat.No: T36628

Synonym: PROTAC BRD4 Degrader-8

Target: PROTACs

PROTAC IRAK4 degrader-6

Cat.No: T39903

Synonym: PROTAC IRAK4 degrader-6

Target: Others

PROTAC IRAK4 degrader-4

Cat.No: T39901

Synonym: PROTAC IRAK4 degrader-4

Target: Others

SHP2 protein degrader-1

Cat.No: T40250

Synonym: SHP2 protein degrader-1

Target: Others

PROTAC CDK9 degrader-4

Cat.No: T39996

Synonym: PROTAC CDK9 degrader-4

Target: Others

PROTAC BRD4 Degrader-13

Cat.No: T40075

Synonym: PROTAC BRD4 Degrader-13

Target: Others

BLK degrader 1

Cat.No: T77518

Target: Others

Cat.No: T36256

Synonym: LC 2,PROTAC KRASG12C Degrader-LC-2,LC2

Target: PROTACs

PROTAC BRAF-V600E degrader-1

Cat.No: T8745

Synonym: Compound 23

Target: Raf, PROTACs

PCSK9 degrader 1

Cat.No: T39685

Target: Others

Akt3 degrader 1

Cat.No: T74982

Target: Akt

PROTAC ERRα Degrader-3

Cat.No: T39837

Target: PROTACs

BRD4 degrader AT1

Cat.No: T5439

Target: Epigenetic Reader Domain, PROTACs

PROTAC PARP1 degrader

Cat.No: T13845

Target: Others

PROTAC RIPK degrader-6

Cat.No: T36243

Target: PROTACs

Cyclin K degrader 1

Cat.No: T83652

Target: Others

PROTAC BET Degrader-10

Cat.No: T39374

Target: PROTACs

PROTAC ERRα Degrader-2

Cat.No: T18609

Target: Others

PROTAC CDK9 Degrader-1

Cat.No: T5438

Target: CDK, PROTACs

PROTAC BRD9 Degrader-1

Cat.No: T12560

Target: Epigenetic Reader Domain, PROTACs

PROTAC MDM2 Degrader-2

Cat.No: T18632

Target: Others, PROTACs

PROTAC MDM2 Degrader-1

Cat.No: T18631

Target: Others, PROTACs

PROTAC RAR Degrader-1

Cat.No: T18635

Target: Others, PROTACs

PROTAC ERα Degrader-2

Cat.No: T18605

Target: Others, PROTACs

PROTAC EED degrader-1

Cat.No: T12553

Target: Others, PROTACs

PROTAC BRD4 Degrader-1

Cat.No: T13833

Target: Epigenetic Reader Domain, PROTACs

PROTAC MDM2 Degrader-4

Cat.No: T18634

Target: Others

PROTAC SGK3 degrader-1

Cat.No: T13847

Synonym: SGK3-PROTAC1

Target: SGK, PROTACs

PROTAC FAK degrader 1

Cat.No: T13840

Target: Others, PROTACs

PROTAC BRD4 Degrader-3

Cat.No: T13835

Target: Epigenetic Reader Domain

PROTAC BRD4 Degrader-2

Cat.No: T13834

Target: Epigenetic Reader Domain

PROTAC Sirt2 Degrader-1

Cat.No: T16667

Target: Sirtuin, PROTACs

PROTAC Mcl1 degrader-1

Cat.No: T11975

Target: BCL, PROTACs

PROTAC CDK9 degrader-2

Cat.No: T17728

Target: Others

PROTAC Bcl2 degrader-1

Cat.No: T10485

Target: BCL, PROTACs

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼