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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T19995 |
C.I. Azoic Coupling Component 5
NSC 37212,NSC37212,Cibanaphthol AG,Diacetylacetotolidide,Daito Grounder G,NSC-37212 |
||
C.I. Azoic Coupling Component 5 is an indicator of fluorescent. | |||
T19996 |
C.I. 37550
Acna Naphthol SS,C.I. Azoic Coupling Component 12,Azoground ITR,Amanil Naphthol AS-ITR,Azotol O,Daito Grounder ITR |
||
C.I. 37550 is an indicator of fluorescent. | |||
T19444 |
N-Biotinyl-6-aminohexanoic acid
N-(+)-Biotinyl-6-aminohexanoic acid,N-生物素己酸 |
Others | Others |
N-Biotinyl-6-aminohexanoic acid(N-(+)-Biotinyl-6-aminohexanoic acid)可用于生物素化反应。 | |||
T19936 |
Xantphos
|
Others | Others |
Xantphos 是 Buchwald, Suzuki 等偶联反应中的配体,是可用于催化反应的金属螯合配体。 | |||
TP1437 |
Fmoc-N-Me-Ala-OH
|
Others | Others |
Fmoc-N-Me-Ala-OH 是一种可用于肽偶联反应的 N-Fmoc-N-甲基氨基酸。 | |||
T30355 |
Benzeneboronic acid
Phenylboric acid,Phenyldihydroxyborane,Phenylboronic acid |
Others | Others |
Benzeneboronic acid (Phenylboronic acid) 是一种用于Mizuroki Heck 和Suzuki Miyaura 偶联反应的硼酸。 | |||
TP1399 |
Fmoc-N-Me-Leu-OH
|
Others | Others |
Fmoc-N-Me-Leu-OH 是 N-Fmoc-N-甲基氨基酸的一种,能够用于肽偶联反应。 | |||
T11956L |
MBC-11
|
Others | Others |
MBC-11 通过将阿糖胞苷和依替膦酸盐浓缩在疾病部位来靶向癌症的偶联物。MBC-11 可溶用于研究肿瘤诱发的骨病。 | |||
T76707 |
Brentuximab vedotin
SGN-35 |
Others; Antibody-Drug Conjugates (ADCs) | Antibody-drug Conjugate/ADC Related; Others |
Brentuximab vedotin (SGN-35) 是一种靶向 CD30 的抗体-活性分子偶联物 (ADC),具有抗肿瘤活性,可研究淋巴瘤。 | |||
T77748 |
Tusamitamab
|
Others | Others |
Tusamitamab 是一种靶向 CEACAM5 的 IgG1 单克隆抗体,是 Tusamitamab ravtansine 的裸抗。Tusamitamab 可用于合成抗体-活性分子偶联物Tusamitamab ravtansine 。 | |||
T21354 |
HATU
|
Others | Others |
HATU 是一种用于肽偶联化学的试剂,用于从羧酸生成活性酯。 HATU 与 Hünig 碱(N,N-二异丙基乙胺,DIPEA)一起使用以形成酰胺键。 | |||
T74305 |
14:0 PEG2000 PE
DMPE-PEG2000 |
Others | Others |
14: 0 PEG2000 PE (DMPE-PEG2000) 是一种聚乙二醇 (PEG)-磷脂偶联物,可在制备囊泡制剂时阻止囊泡聚集,可用于制备纳米结构脂质载体。 | |||
T36646 |
Trastuzumab deruxtecan
DS-8201a,VRN-101099,DS 8201,T-DXd |
Others; Antibody-Drug Conjugates (ADCs) | Antibody-drug Conjugate/ADC Related; Others |
Trastuzumab deruxtecan (T-DXd) 是一种具有抗癌抗肿瘤活性的抗体-活性分子偶联物 (ADC)。Trastuzumab deruxtecan 对 HER2 阳性乳腺癌和胃癌有改善作用。 | |||
T74178 |
Glembatumumab vedotin
CR011-vcMMAE,CR 011 ADC,CDX-011 |
Microtubule Associated; Antibody-Drug Conjugates (ADCs) | Antibody-drug Conjugate/ADC Related; Cytoskeletal Signaling |
Glembatumumab vedotin (CDX-011) 是一种抗体活性小分子偶联物,Glembatumumab vedotin 具有强大的抗癌作用,可用于研究三阴性乳腺癌(TNBC)。 | |||
T83633 |
1-N-Methyl-4-mercaptohistidine disulfide
|
Others | Others |
1-N-Methyl-4-mercaptohistidine disulfide 是一种潜在的杜氏菌叶绿体偶联因子1氧化还原调节剂,是氧化形式的卵硫醇A,抑制光触发的CF1 ATP酶活性。 | |||
T19780 |
2,2′-Dipyridyl disulfide
2,2'-Dipyridyl disulfide,OPSS,2,2'-二硫二吡啶,Aldrithiol 2,Orthopyridyl disulfide |
Others | Others |
2,2′-Dipyridyl disulfide (Aldrithiol 2) 是肽化学中的常用试剂,是测定巯基的有用试剂,常用于氧化还原缩合以形成肽键或用于偶联反应以形成二硫键连接的异二聚体。 | |||
T77477 |
Polatuzumab
|
ADC Antibody | Antibody-drug Conjugate/ADC Related |
Polatuzumab 是一种靶向 CD79b 的单克隆抗体,可携带化疗活性分子。Polatuzumab 粘附在 CD79b 蛋白上并将化疗活性分子转运到细胞中用来杀死细胞。Polatuzumab 可用于合成抗体-化合物偶联物 Polatuzumab Vedotin。 | |||
T24807 |
S-Methylglutathione
Glutathione S-methyl ester,Glutathione ester,S-Methyl glutathione |
Glyoxalase | Proteases/Proteasome |
S-Methylglutathione (S-Methyl glutathione) 是一种 S 取代的谷胱甘肽,是一种转移酶A催化的1-氯-2,4-二硝基苯偶联物的抑制剂,也是一种 XOCl 清除剂。S-Methylglutathione 抑制乙二醛酶 1 (glyoxalase 1) ,诱导水螅触手球形成。 | |||
T0077 |
Dantrolene sodium
Lapatinib ditosylate monohydrate,丹曲林钠,Dantrolene sodium salt |
Others; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Others |
Dantrolene sodium (Lapatinib ditosylate monohydrate) salt 是一种骨骼肌松弛药,是一种钙通道蛋白抑制剂,可抑制钙离子从肌浆释放。 | |||
T76857 |
Anetumab
|
Others | Others |
Anetumab 是一种新型全人源抗间皮素 IgG1抗体,是 Anetumab ravtansine的裸抗。Anetumab 可用于合成抗体-活性分子偶联物 Anetumab ravtansine。Anetumab 可用于研究治疗转移性胸膜间皮瘤。 | |||
T77948 |
Tri-GalNAc-DBCO
|
PROTACs | PROTAC |
Tri-GalNAc-DBCO是一种PIP-GalNAc 偶联物,通过无铜菌株促进的叠氮化物-炔烃环加成与非特异性标记抗体上的叠氮化物偶联,可结合ASGPR以驱动蛋白质下调和靶向蛋白质降解的化合物。 | |||
T4054 |
Dantrolene sodium hemiheptahydrate
Dantrolene sodium hydrate,Dantrolene sodium salt,Dantrium,丹曲林钠五水合物,Sodium dantrolene |
Calcium Channel; Autophagy | Autophagy; Membrane transporter/Ion channel; Metabolism |
Dantrolene sodium hemiheptahydrate (Sodium dantrolene) 是一种钙通道蛋白抑制剂, 抑制钙离子从肌浆释放, 它是一种乙内酰脲衍生物和直接作用的骨骼肌松弛剂。 | |||
T77415 |
Ladiratuzumab
hLIV22 |
Others | Others |
LadiratuzumAb (hLIV22) 是一种人源化靶向 LIV-1/ZIP6 的单克隆抗体。LadiratuzumAb 是 SGN-LIV1A 的裸抗,能够合成一种抗体-活性分子偶联物 (ADC) SGN-LIV1A。LadiratuzumAb 可用于预防和治疗乳腺癌究。 | |||
T76142 |
Laccase
Denilite IIS |
Antibacterial | Microbiology/Virology |
Laccase (Denilite IIS)是一种广泛存在于微生物、植物和真菌中的多铜氧化酶(MCOs),具有抗菌活性和细胞毒性,可用于研究癌症。Laccase 促进单木质素的氧化偶联在木质素的形成。 | |||
T18988 |
FITC-Dextran (MW 10000)
FITC-Dextran,荧光素异硫氰酸酯-葡聚糖(MW 10000),荧光素异硫氰酸酯-葡聚糖 |
Others | Others |
FITC-Dextran (MW 10000) (FITC-Dextran) 是由 FITC 偶联葡聚糖形成的标记物 (10 kDa)。它是由不同长度的支链葡萄糖分子组成的被标记的多糖,能够依照所使用的葡聚糖的大小,测定血脑屏障的溶质、离子和蛋白质渗透性。 | |||
TP2158 |
TRV-120027 TFA
TRV-120027 TFA (1234510-46-3 free base) |
RAAS; Arrestin | Endocrinology/Hormones; GPCR/G Protein |
TRV-120027 TFA 是一种血管紧张素 II 介导的血管收缩抑制剂,可增加心肌细胞的收缩力。它是一种偏向 β-arrestin-1 的 AT1R 激动剂,可与 ß-arrestins 结合,同时阻断 G 蛋白信号传导。 它通过阳离子通道亚家族 C3 (TRPC3) 偶联诱导急性儿茶酚胺分泌,并促进在质膜上形成由 AT1R-β-arrestin-1-TRPC3-PLCγ 组成的大分子复合物。 | |||
T19598 |
UMP-morpholidate
|
Others | Others |
UMP-morpholidate is an intermediate of pharmaceutical synthesis by coupling. | |||
T20150 |
C.I. 37505
3-Hydroxy-2-naphthanilide,2-Naphthanilide, 3-hydroxy- (8CI) |
||
C.I. 37505 is an azo dye coupling component.It implicated in occupational pigmented contact dermatitis. | |||
T40788 |
PYBG
|
||
PYBG serves as a flexible precursor for facile conjugation with diverse fluorescent dyes using 'Click chemistry' and Sonogashira coupling reactions. | |||
T34458 |
Ryanodol
|
Others | Others |
Ryanodol is a complex diterpenoid that modulates intracellular calcium-ion release at ryanodine receptors, ion channels critical for skeletal and cardiac muscle excitation-contraction coupling and synaptic transmission. | |||
T19903 |
Alizarine Yellow R
C.I. 14030 |
||
Alizarine Yellow R is a yellow colored azo dye. Alizarine Yellow R made by the diazo coupling reaction. | |||
T40946 |
Seph-PAO
|
||
Seph-PAO, a modified form of polyalphaolefin (PAO) compound, is created by coupling a sepharose fluorophore. Its primary application lies in the detection of thioredoxin reductase (TrxR). | |||
T71021 |
Fendiline
|
Others | Others |
Fendiline is a coronary vasodilator that inhibits calcium function in muscle cells in excitation-contraction coupling; proposed as an antiarrhythmic and antianginal agent. | |||
T38997 |
BCN-PEG4-HyNic
BCN-PEG4-HyNic |
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
BCN-PEG4-HyNic is a cleavable four-unit PEG linker utilized in ADC synthesis for coupling drugs to antibodies, creating antibody-drug conjugates (ADCs). | |||
T21356 |
4-(Trifluoromethyl)phenylboronic acid
|
Others | Others |
4-(Trifluoromethyl)benzeneboronic acid is used to N-arylate imidazoles and amines with copper-exchanged fluorapatite, as well as used in microwave-promoted cross-coupling with acid chlorides leading to aryl ketones. | |||
T71923 |
EEDQ
|
Others | Others |
EEDQ is an irreversible dopamine-receptor antagonist.EEDQ is also a highly specific reagent for carboxyl groups. It enables the coupling of acylamino acids with amino acid esters in high yield and without racemization. | |||
T21125 |
Decane, 1-iodo-
1-Iododecane |
Others | Others |
Decane, 1-iodo- is used as an intermediate in organic synthesis. Through palladium-catalyzed carbonylative cross-coupling reaction with 9-octyl-9-borabicyclo[3.3.l]nonane, it is also used as a precursor to prepare 9-nonadecanone. | |||
T38611 |
Seco-DUBA
|
Others; ADC Cytotoxin | Antibody-drug Conjugate/ADC Related; Others |
Seco-DUBA, a duocarmycin (DUBA) prodrug, possess two hydroxyl groups suitable for antibody coupling through a linker. This compound, serving as a precursor, enables the synthesis of antibody-drug conjugates (ADCs). | |||
T18220 |
m-PEG8-ethoxycarbonyl-NHS ester
|
Others | Others |
m-PEG8-ethoxycarbonyl-NHS ester is a polyethylene glycol (PEG)-based linker, utilized for the synthesis of PROTACs. It serves as an effective coupling agent, facilitating the conjugation of two molecules within PROTACs. This compound offers a stable and efficient platform for the delivery of targeted protein degradation therapeutics. [1] | |||
T82291 |
Glycine, N-[(1,1-dimethylethoxy)carbonyl]thio-L-phenylalanyl-, methyl ester
|
Others | Others |
Glycine, N-[(1,1-dimethylethoxy)carbonyl]thio-L-phenylalanyl-, methyl ester (compound 3b) 是一种化合物,其多肽链末端含有磺胺基团,主要应用于多肽与活性分子偶联化合物的合成。 | |||
T84910 |
Lenalidomide 4'-alkyl-C5-azide
SUN55786,SUN 55786,Lenalidomide 4'-alkylC5-azide,SUN-55786 |
Others | Others |
Lenalidomide 4'-alkyl-C5-azide为一种功能化的小分子 ligand,专为PROTAC研发而设计,结合了E3 ligase ligand及带末端叠氮化物的烷基LC5 linker,用于与目标蛋白质的ligand进行偶联。 | |||
T25774 |
Manninotrionate
|
Others | Others |
Manninotrionate 是一种抗肿瘤化合物。将Manninotrionate 与BSA 偶联,并在兔体内制备了这种化合物-蛋白质偶联物的抗血清。该抗血清不凝集 Ehrlich 腹水肿瘤细胞,该细胞已被证明含有具有α-D-半乳糖基端基的细胞表面糖蛋白。 | |||
T60305 |
ZLc-002
|
Others | Others |
ZLc-002 是一种选择性的 nNOS-Capon 偶联小分子抑制剂。ZLc-002 抑制炎症和化疗引起的神经性疼痛。ZLc-002 可用于焦虑和炎症研究。 | |||
T79636 |
PKM2-IN-4
|
Others | Others |
PKM2-IN-4 (compound 5C)为PKM2的选择性抑制剂,具有0.35 μM的半抑制浓度(IC50),能够调控丙酮酸依赖的呼吸作用,并诱导线粒体H202的产生和电子传递系统的偶联效应。 | |||
T78191 |
NH2-C6-ARC186
|
Complement System | Immunology/Inflammation |
NH2-C6-ARC186是带有NH2-C6接头的ARC186衍生物,可用于与其他肽或分子偶联。它作为一种适体,是一种高效的补体抑制剂,通过抑制转化酶催化的C5活化发挥作用。 | |||
T39504 |
PA Janelia Fluor® 646, SE
PA-JF646-NHS |
||
PA Janelia Fluor 646, SE (PA-JF646-NHS), a photoactivatable fluorescent dye, is an NHS ester for coupling to primary amine groups. PA-JF646-NHS is non-fluorescent until activated at 365 nm. NHS ester can be converted to relevant substrate for use in self-labeling tag systems, e.g.HaloTag and SNAP-tag . PA-JF646-NHS is used for single molecule tracking and super resolution microscopy in live cells, specifically live cell sptPALM and fixed cell PALM. (λ Excitation/emission ~650/664 nm). | |||
T81048 |
TAMRA hydrazide (6-isomer)
|
||
TAMRA hydrazide (6-isomer) 作为点击化学试剂,特定于与羰基化合物,如醛和酮发生偶联反应。其中,TAMRA 组件作为一种红色荧光团,能与末端炔烃进行反应,实现荧光标记。 | |||
T82903 |
Bdp tr nhs ester
|
||
Bdp tr nhs ester 是一种具有长激发态寿命的化学发光偶联物,适用于免疫测定及显微镜和荧光偏振分析。该NHS ester 在中性或弱碱性环境中能特异性地与伯胺(如赖氨酸残基侧链)或氨基硅烷涂层表面发生反应,形成稳定的共价键。 | |||
T84762 |
DIBAC-GGFG-NH2CH2-Dxd
|
Others; Drug-Linker Conjugates for ADC | Antibody-drug Conjugate/ADC Related; Others |
DIBAC-GGFG-NH2CH2-Dxd(化合物LP4)作为Camptothecin衍生物,用作蛋白质-活性分子偶联体的链接介质。该化合物在抗体药物偶联体ADC(DS-8201a)中作为有效载荷发挥功能。作为一种点击化学试剂,含DBCO基团的DIBAC-GGFG-NH2CH2-Dxd能与含Azide基团的分子通过菌株促进的炔-叠氮环加成反应(SPAAC)发生反应。 | |||
T82842 |
BODIPY FL EDA free base
|
||
ODIPY FL EDA free base为绿色荧光胺类探针,能通过R-NH2与醛或酮反应形成可逆的席夫碱产物。使用如硼氢化钠或氰硼氢化钠等还原剂,ODIPY FL EDA free base可转化成稳定的胺衍生物,适用于检测修饰或未修饰脱氧核苷酸,以及评估DNA损伤和基因组DNA甲基化情况。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4292 |
Thiaproline
L-Thioproline,L-Thiaproline,L-硫代脯氨酸 |
Others | Others |
Thiaproline 已用于肽偶联反应。 | |||
Fr12596 |
3-Acetylcoumarin
|
Others | Others |
3-Acetylcoumarin 作为室温下铜催化 CN 偶联反应的实用配体。它具有神经保护和杀螨特性。 | |||
T74862 |
N-Lactoyl-Phenylalanine
N-Lactoylphenylalanine |
Endogenous Metabolite | Metabolism |
N-Lactoyl-Phenylalanine (Lac-Phe) 是一种乳酸和苯丙氨酸的肽偶联物,是急性运动中代谢物之一,可用于研究肥胖和代谢相关疾病。 | |||
T6323 |
Oligomycin A
MCH 32,寡霉素A |
ATPase; Antibiotic; Antifungal | Membrane transporter/Ion channel; Microbiology/Virology |
Oligomycin A (MCH 32) 属于天然产物,是一种线粒体 F0F1-ATPase 抑制剂 (Ki=1 μM)。Oligomycin A 可以抑制线粒体氧化磷酸化,诱导细胞凋亡。Oligomycin A 具有抗真菌活性。 | |||
T0864 |
L-Thyroxine
Levothyroxine,NSC 36397,L-甲状腺素,T4 |
Thyroid hormone receptor(THR); Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
L-Thyroxine (NSC 36397) 是一种合成的甲状腺激素,用于甲状腺功能减退症的研究。在 DIO 酶作用下,L-Thyroxine (NSC 36397) 转化成具有生物特性的三碘甲状腺氨酸(T3)。 | |||
T13753 |
(±)-Licarin A
(±)-trans-Dehydrodiisoeugenol |
Others | Others |
(±)-Licarin A ((±)-trans-Dehydrodiisoeugenol) is a dihydrobenzofuran neolignan, the resultant of an oxidative coupling reaction of isoeugenol and horseradish peroxidase (HRP) enzyme. (±)-Licarin A shows 100% parasites mortality at 200 μM. | |||
T82277 |
GM1a Ganglioside oligosaccharide
|
||
GM1a Ganglioside oligosaccharide为ganglioside GM1的半合成形式,后者作为霍乱毒素的天然受体,在生长调节及激素诱导反应的耦合中具有关键功能。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMID-0104 |
L-Thyroxine-13C6
|
||
L-Thyroxine-13C6 是 L-Thyroxine 的 13C 的标记化合物。L-Thyroxine 的 CAS 号为 51-48-9。L-Thyroxine (T4)是一种合成的甲状腺激素,用于甲状腺功能减退症的研究。在DIO 酶作用下, L-Thyroxine (T4)转化成具有生物特性的三碘甲状腺氨酸 (T3)。 |