43
8
1
78
Cat. No. | Product Name | ||
---|---|---|---|
L7500 | 凝血与抗凝化合物库 | 144 compounds | |
144 个化合物的独特集合,可用于高通量筛选和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP2234 |
coagulation factor II (thrombin) B chain fragment [Homo sapiens]
|
Others | Others |
Thrombin is a "trypsin-like" serine protease that is encoded by the F2 gene in humans. Thrombin is produced by the enzymatic cleavage of two sites on prothrombin by activated Factor X (Xa). Thrombin in turn acts as a serine protease that converts soluble | |||
T81655 |
Nonacog alfa
BAX326,Coagulation Factor IX [Recombinant] |
||
Nonacog alfa (BAX326)为重组人凝血因子IX,主要用于血友病B临床研究。 | |||
T4502 |
BISMUTH SUBGALLATE
次没食子酸铋,Dermatol Puder,Bismuth Gallate |
Others | Others |
Bismuth subgallate (Dermatol Puder) 是一种止血剂,可作用于凝血因子 XII ,促使凝血级联的激活,改善纤维蛋白凝块的早期形成。 | |||
T67853 |
Rivaroxaban Impurity
Rivaroxaban-10 |
Factor Xa | Metabolism |
Rivaroxaban Impurity (Rivaroxaban-10) 是一种强效凝血因子Xa 抑制剂,IC50=66 nM。 | |||
T27920 |
LY 517717
LY-517717,LY517717 |
Factor Xa | Metabolism |
LY 517717 是一种具有口服活性的凝血因子 Xa 抑制剂,具有抗血栓活性,可用于研究静脉血栓栓塞(VTE)。 | |||
T3469 |
PCI-27483
PCI27483 |
Others | Others |
PCI-27483 是一种FVIIa/tissue factor 抑制剂,具有抗肿瘤的作用。 | |||
T0372 |
Gabexate mesylate
甲磺酸加贝酯,FOY |
Factor Xa; Serine Protease; Proteasome | Metabolism; Proteases/Proteasome; Ubiquitination |
Gabexate mesylate (FOY) 是一种非抗原的类胰蛋白酶丝氨酸蛋白酶抑制剂。 | |||
T7674 |
Thrombin Receptor Activator for Peptide
|
Protease-activated Receptor | GPCR/G Protein |
Thrombin Receptor Activator for Peptide 也称为凝血因子 II 受体 (1-5) 或蛋白酶激活受体 1 (1-5),用于研究冠心病 (CHD)。 | |||
T83969 |
Casein
|
Hydroxylase | Metabolism |
Casein 是一种具有多种作用的牛奶蛋白,参与新型药物递送系统,通过其胃内凝血特性以不同的方式影响餐后氨基酸递送。 | |||
T66256 |
Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
|
Factor Xa | Metabolism |
Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate 对凝血因子Xa具有抑制作用,可用于研究血栓性静脉炎、动脉粥样硬化、脑栓塞、中风、肺栓塞。 | |||
T1736 |
Apixaban
阿哌沙班,BMS-562247-01 |
Factor Xa | Metabolism |
Apixaban (BMS-562247-01) 是一种高度选择性,可逆的、口服具有活力的凝血因子 Xa (Factor Xa) 抑制剂,抑制人和兔凝血因子 Xa 的 Ki 分别为 0.08 nM 和 0.17 nM。它可以用于研究各种血栓栓塞疾病。 | |||
T78362 |
Transglutaminase
TG |
||
Transglutaminase (TG) 是一种硫醇酶,促使蛋白质分子间交联,通过催化谷氨酰胺残基的γ-羧酰胺基团与其他化合物的一级ε-胺基团形成异肽键。该酶在包括凝血、抗菌免疫反应和光合作用在内的多种生理过程中发挥作用。 | |||
T11994 |
Melagatran
|
Thrombin | Proteases/Proteasome |
Melagatran 是一种直接作用且可口服的凝血酶抑制剂。Melagatran 专一性抑制凝血酶,但不影响凝血级联中的其他酶或纤溶酶。Melagatran不依赖内源性辅因子发挥其抗凝血酶效果,可缓解内毒素血症的有害影响。因此,Melagatran作为预防动脉闭塞的策略显示出前景。 | |||
T1184 |
Rivaroxaban
BAY 59-7939,利伐沙班 |
Factor Xa; Thrombin | Metabolism; Proteases/Proteasome |
Rivaroxaban (BAY 59-7939) 是高效选择性的凝血因子 Xa (FXa) 直接抑制剂,IC50=0.7 nM,Ki 为 0.4 nM。 | |||
T20762 |
Sivelestat sodium tetrahydrate
ONO-5046 sodium tetrahydrate,Elaspol,ONO 5046,ONO5046 sodium tetrahydrate,Elaspol sodium tetrahydrate,ONO-5046,Sivelestat Sodium,Sivelestat Sodium Hydrate,ONO5046 |
Serine Protease | Proteases/Proteasome |
Sivelestat sodium tetrahydrate (ONO5046 sodium tetrahydrate) 是竞争性的人类中性粒细胞弹性蛋白酶的抑制剂,其 IC50 值为 44 nM, Ki 值为 200 nM。Sivelestat (EI546) sodium tetrahydrate 有潜力用于 COVID-19的急性肺损伤/急性呼吸窘迫综合征或弥散性血管内凝血的研究。 | |||
T39463 |
Asundexian
BAY 2433334,Asundexian,BAY2433334,BAY-2433334 |
Factor Xa | Metabolism |
Asundexian (BAY-2433334) 是一种高效且具有口服活性凝血因子 FXIa 抑制剂,可直接且可逆地与FXIa 的活性位点结合,从而抑制其活性。Asundexian 对缓冲液中的人 FXIa 的 IC50 为 1 nM。Asundexian 具有抗肿瘤活性,可用于研究急性缺血性卒中、短暂性脑缺血发作和缺血性卒中。 | |||
T26240 |
Surfen dihydrochloride
Aminokinuride dihydrochloride,Aminoquinuride dihydrochloride,NSC-12155,Aminokinuride 2HCl,Aminoquinuride 2HCl |
FGFR; Antiviral; Antibiotic | Angiogenesis; Immunology/Inflammation; Microbiology/Virology; Tyrosine Kinase/Adaptors |
Surfen dihydrochloride (Aminoquinuride dihydrochloride) 是一种有效的硫酸肝素小分子拮抗剂,具有抗菌和抗病毒活性,抑制炭疽致死因子、凝血因子 X 和致死因子。Surfen dihydrochloride 可抑制普通肝素和低分子量肝素的抗凝活性,抑制肝素的硫酸化和肝素裂解酶的降解。Surfen dihydrochloridn 抑制阻断硫酸乙酰肝素介导的 FGF2 结合和信号转导。Surfen 抑制 SEVI 和精液介导的 HIV 1 型感染增强。 | |||
T0815L |
Warfarin sodium
|
Others | Others |
Warfarin sodium 是一种抗凝血剂,通过抑制维生素 K 依赖性凝血因子的合成起作用。华法林适用于预防和/或治疗静脉血栓形成及其延伸、肺栓塞和房颤栓塞。它还用作预防心肌梗塞后全身性栓塞的辅助剂。华法林也用作杀鼠剂。 | |||
T22323 |
Enoxaparin sodium
|
Thrombin | Proteases/Proteasome |
Enoxaparin sodium 是一种低分子量肝素 (LMWH),已获得美国 FDA 批准,可用于医疗管理的 ST 段心肌梗死 (STEMI) 或 STEMI 及随后的经皮冠状动脉介入治疗 (PCI) 患者。它与抗凝血酶结合并增强其作用,并抑制凝血因子 XIa、IXa、Xa 和 IIa(凝血酶),从而防止血栓形成。 | |||
T31370 |
Delparantag
PMX60056,PMX-60056,PMX 60056 |
||
Delparantag( PMX-60056) is a heparins antidote designed to restore coagulation. | |||
T25927 |
Pegnivacogin
RB-006,RB 006,RB006 |
Others | Others |
Pegnivacogin is a coagulation factor IXa RNA aptamer inhibitor. | |||
T20616 |
Coumachlor
G-23133,Ratilan,G23133,Tomorin,G 23133 |
Others | Others |
Coumachlor, a first-generation anticoagulant rodenticide, blocks the formation of prothrombin and inhibits blood coagulation causing internal haemorrhage. | |||
T69353 |
Darexaban maleate
|
Others | Others |
Darexaban maleate is a derivative used in the preparation of inhibitors of activated blood coagulation factor X. | |||
T28921 |
Tanogitran
BIBT 986,BIBT986,BIBT-986 |
Others | Others |
Tanogitran, a coagulation factor Xa inhibitor, is used potentially for the treatment of septic shock. | |||
T80095 |
D-Pro-Phe-Arg-Chloromethylketone
|
Factor Xa | Metabolism |
D-Pro-Phe-Arg-Chloromethylketone是一种抑制剂,它针对凝血因子XII (coagulation factor XII) 和血浆激肽释放酶 (kallikrein),在血栓形成和炎症过程中具有关键作用。 | |||
T22676 |
Prothrombin (474-477) [Mus musculus]
|
Others | Others |
Prothrombin (coagulation factor II) is produced in the liver and is post-translationally modified in a vitamin K-dependent reaction that converts ten glutamic acids on prothrombin into gamma-carboxyglutamic acid. Prothrombin is proteolytically cleaved to | |||
T81234 |
S-(1,2-Dicarboxyethyl)glutathione
|
||
S-(1,2-Dicarboxyethyl)glutathione为多肽类化合物,具有抑制血液凝固与血小板聚集的功能。 | |||
T64298 |
Turoctocog alfa
|
Others | Others |
Turoctocog alfa 是一种来源于中国仓鼠卵巢 (CHO) 细胞的重组凝血因子 VIII (FVIII)。Turoctocog alfa 能够用于研究 A 型血友病。 | |||
T77109 | Omfiloctocog alfa | ||
Omfiloctocog alfa (SCT-800) 是一种重组的 factor VIII(FVIII)。FVIII 是一种必需的凝血蛋白,是液相凝血系统的关键组成部分。Omfiloctocog alfa 可用于血友病 A 的研究。 | |||
T82499 |
Efmoroctocog alfa
|
Others | Others |
Efmoroctocog alfa,一种重组人凝血因子 VIII-Fc 融合蛋白(rFVIIIFc),主要应用于血友病 A 研究。 | |||
T29190 |
YM-75466
YM 466,YM-466,YM75466,YM 75466,YM-75466 Free |
Others | Others |
YM-75466 is a factor Xa inhibitor. YM-75466 did not prolong coagulation time even at the dose which exerted significant antithrombotic effects, while it decreased TAT level in plasma in a dose-dependent manner. | |||
T76619 |
Methoxycarbonyl-D-Nle-Gly-Arg-pNA
|
||
Methoxycarbonyl-D-Nle-Gly-Arg-pNA,这是一种底物,主要用于FIXa (Factors IXa) 和 FXa (Factors Xa)的合成蛋白酶。 | |||
TP1580 |
Activated Protein C (390-404), human TFA
|
||
The peptide region containing residues 390-404 in Activated Protein C (APC) is essential for anticoagulant activity and is available for interaction with antibodies or with other proteins, such as the macromolecular substrates Factors Va or VIIIa. APC reg | |||
TP1129 |
Boc-Ile-Glu-Gly-Arg-AMC
IEGR-AMC |
||
Boc-Ile-Glu-Gly-Arg-AMC (IEGR-AMC), a specific, highly fluorogenic substrate for clotting enzyme factor Xa (coagulation factor Xa). Boc-IEGR-AMC is also hydrolyzed by acrosin from the ascidian Halocynthia roretzi. | |||
T7496 |
Thrombin Receptor Activator for Peptide 5 (TRAP-5)
Thrombin Receptor Activator for Peptide |
Protease-activated Receptor | GPCR/G Protein |
Thrombin Receptor Activator for Peptide 5 (TRAP-5) 也称为凝血因子 II 受体 (1-5) 或蛋白酶激活受体 1 (1-5),用于研究冠心病 (CHD)。 | |||
T70170 |
Milvexian TFA
|
Others | Others |
Milvexian, also known as BMS-986177 and JNJ-70033093, is a blood coagulation factor XIa inhibitor. Milvexian demonstrated good selectivity over plasma kallikreinKi = 44 nM (400-fold selective), and chymotrypsinKi = 35 nM (318-fold selective). At a dose of 1.5 mg/kg, Milvexian exhibited an overall exposure of 1215 nM/h, low clearance of 10.3 mL/min/kg, and oral bioavailability of 32%. | |||
T82585 |
Denecimig
Mim8 |
Factor Xa | Metabolism |
Denecimig (Mim8) 是活化凝血因子VIII双特异性抗体,包含抗FIXa和抗FX臂,促进FX活化,实现体外及体内止血。 | |||
T79847 |
Frunexian
EP-7041 |
Factor Xa | Metabolism |
Frunexian (EP-7041) 为针对 Factor XIa 的选择性有效凝血因子 XI/活化因子 XI 抑制剂,展现抗血栓活性,且在大鼠肠系膜动脉穿刺模型中显示出无出血倾向。此化合物亦可应用于体外膜氧合(ECMO)的研究领域。 | |||
T82526 |
Drotrecogin alfa (activated)
|
Others | Others |
Drotrecogin alfa activated (DrotAA)为重组人活化蛋白C(APC)。该化合物能够抑制由烟雾引起的大鼠肺微血管通透性上升及促炎细胞因子IL-1β水平增加,具有抗凝血与抗炎作用,并促进纤溶过程。Drotrecogin alfa activated主要用于重症脓毒症的实验研究。 | |||
T74647 |
BT5528
|
Others | Others |
BT5528 是一种双环肽毒素结合物,一种EphA2激活剂。BT5528 由双环肽和AuristatinE 组成,是 BCY6099 的衍生物。BT5528 在大鼠模型中显示出强大的抗肿瘤活性,不导致出血或引起凝血毒性。 | |||
T30192 |
Atecegatran metoxil
Atecegatran fexenetil,AZD-0837,AZD 0837,AZD0837 |
Others | Others |
Atecegatran Metoxil (Atecegatran Fexenetil ,AZD0837) is an oral direct thrombin inhibitor,which currently in clinical development for the prevention of stroke and systemic embolic events in patients with atrial fibrillation. AZD0837 is a selective and re | |||
T80240 |
Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2
|
||
Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2是一类具有生物活性的肽,作为蛋白酶激活受体1 (PAR-1) 的选择性激动剂,其特异性优于PAR-2。该肽通过HEK293细胞进行的基于细胞的钙信号传导测定确认了其对PAR-1的高特异性,并可用于研究PAR-1在体内的激活。PAR-1除了介导凝血酶的多种细胞作用外,还与PAR-4协作,参与调控凝血酶诱导的被分类为“凝血型”的肝细胞癌。 | |||
T11864 |
Iptacopan
LNP023 |
Others | Others |
Iptacopan (LNP023) 是一种与factor B 亲和力较高的抑制剂。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T19603 |
Vitamin K
Kephton,维生素K,Vitamin K1(20) |
Endogenous Metabolite | Metabolism |
Vitamin K (Kephton) 具有凝血作用,对凝血因子、基质-Gla 蛋白和骨钙素很重要。 | |||
T11012 |
Dextran
Dextran 40,葡聚糖 |
Platelet aggregation | Others |
Dextran 对血小板聚集和凝血因子有抑制作用,用作增加血浆容量的药剂。 | |||
T4S1658 |
Benzoyloxypaeoniflorin
苯甲酰氧化芍药苷,Benzoyloxypeoniflorin,苯甲酰氧芍药苷 |
NF-κB; Tyrosinase | NF-κB; Proteases/Proteasome |
Benzoyloxypaeoniflorin (Benzoyloxypeoniflorin) 是一种酪氨酸酶抑制剂,分离于Paeonia suffruticosa 的根,对mushroom tyrosinase 的 IC50为 0.453 mM。它是一种NF-κB 抑制剂,它通过对血小板聚集和凝血的抑制作用,有助于改善血液循环。 | |||
T2570 |
Vitamin K4
维生素K4,维生素 K4,Kapilin,Menadiol Diacetate,acetomenaphthone |
Apoptosis; Endogenous Metabolite | Apoptosis; Metabolism |
Vitamin K4 (Menadiol Diacetate) 是一种维生素药物,用于治疗因缺乏 VK4 引起的凝血障碍。 | |||
T5968 |
DL-Homocysteine thiolactone hydrochloride
DL-Homocysteinethiolactone hydrochloride,DL-高半胱氨酸硫内酯盐酸盐 |
Endogenous Metabolite | Metabolism |
DL-Homocysteine thiolactone hydrochloride (DL-Homocysteinethiolactone hydrochloride) 是具有根生长抑制特性的环状氨基酸衍生物。 | |||
T13693 |
Fibrin
|
Others | Others |
Fibrin 是血凝块的主要成分,为一种不溶性蛋白质,对凝血过程至关重要。这种蛋白质从牛血中分离出来,特别是在出血时合成。 | |||
TL0001 |
dencichine
L-Dencichin,ODAP,Dencichin,三七素 |
Others; HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism; Others |
Dencichine (ODAP) 是抑制从三七中分到的非蛋白氨基酸,可抑制 HIF-prolyl hydroxylase-2 的活性。 | |||
T3229 |
Cytochalasin D
|
ATPase; p38 MAPK; Calcium Channel; Akt; PI3K | Cytoskeletal Signaling; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling |
Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertilization processes such as sperm penetration or sperm head decondensation. Cytochalasin D inhibit |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01104 |
Coagulation factor XI/F11 Protein, Human, Recombinant (His)
coagulation factor 11,coagulation factor X... |
Human | HEK293 Cells |
Factor XI (plasma thromboplastin antecedent) is a plasma glycoprotein, and a zymogen acting as a serine protease which participates in blood coagulation as a catalyst in the conversion of factor IX to factor IXa in the presence of calcium ions. It is an unusual dimeric protease, with structural features that distinguish it from vitamin K-dependent coagulation proteases. The factor XI is synthesized in the liver as a single polypeptide chain with a molecular weight estimated between 125 ~160 kDa ... | |||
TMPY-02185 |
Coagulation factor XIII B/F13B Protein, Human, Recombinant (His)
Coagulation factor 13,coagulation factor X... |
Human | HEK293 Cells |
Coagulation factor XIII B chain, also known as Fibrin-stabilizing factor B subunit, Protein-glutamine gamma-glutamyltransferase B chain, Transglutaminase B chain and F13B, is a secreted protein which contains 1 Sushi ( CCP / SCR ) domains. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have en... | |||
TMPY-02215 |
Coagulation factor IX/F9 Protein, Human, Recombinant (His)
FIX,PTC,Coagulation factor 9,coagulation f... |
Human | HEK293 Cells |
Coagulation factor IX/F9 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50 kDa and the accession number is AAB59620.1. | |||
TMPY-01101 |
Coagulation factor X/F10 Protein, Human, Recombinant (His)
FXA,FX,coagulation factor X,coagulation fa... |
Human | Baculovirus Insect Cells |
Coagulation factor X, also known as FX, F10, Eponym Stuart-Prower factor, and thrombokinase, is an enzyme of the coagulation cascade. It is one of the vitamin K-dependent serine proteases, and plays a crucial role in the coagulation cascade and blood clotting, as the first enzyme in the common pathway of thrombus formation. Factor X deficiency is one of the rarest of the inherited coagulation disorders. FX deficiency among the most severe of the rare coagulation defects, typically including hema... | |||
TMPY-02530 |
Tissue Factor Protein, Human, Recombinant (His)
CD142,coagulation factor III (thromboplastin, tissu... |
Human | HEK293 Cells |
Tissue Factor Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.2 kDa and the accession number is P13726. | |||
TMPY-05094 |
Tissue Factor Protein, Cynomolgus, Recombinant (His)
coagulation factor III (thromboplastin, tissue fact... |
Cynomolgus | HEK293 Cells |
Tissue Factor Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.4 kDa and the accession number is XP_005542723.1. | |||
TMPY-02014 |
Coagulation factor VII/F7 Protein, Human, Recombinant (His)
coagulation factor VII (serum prothrombin conversio... |
Human | HEK293 Cells |
Coagulation factor VII, also known as Serum prothrombin conversion accelerator, Factor VII, F7 and FVII, is a member of the peptidase S1 family. Factor VII is one of the central proteins in the coagulation cascade. It is an enzyme of the serine protease class, and Factor VII (FVII) deficiency is the most frequent among rare congenital bleeding disorders. Factor VII contains two EGF-like domains, one Gla (gamma-carboxy-glutamate) domain and one peptidase S1 domain. The main role of factor VII is ... | |||
TMPY-04996 |
Coagulation Factor II Protein, Rat, Recombinant (His)
coagulation factor II (thrombin) |
Rat | HEK293 Cells |
Coagulation Factor II Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 69.5 kDa and the accession number is A6HND0. | |||
TMPY-05355 |
Coagulation factor IX/F9 Protein, Human, Recombinant (hFc)
P19,Coagulation factor 9,HEMB,FIX,THPH8,Coagula... |
Human | HEK293 Cells |
Coagulation factor IX/F9 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 75.5 kDa and the accession number is P00740-1. | |||
TMPY-06714 |
Coagulation factor IX/F9 Protein, Cynomolgus, Recombinant (His)
coagulation factor IX |
Cynomolgus | HEK293 Cells |
Coagulation factor IX/F9 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50.17 kDa and the accession number is A0A8J8XCV8. | |||
TMPK-01271 |
Coagulation factor XI Protein, Cynomolgus, Recombinant (His)
F11,PTA,FXI,Coagulation factor XI |
Cynomolgus | HEK293 Cells |
Factor XI (FXI) is the zymogen of a plasma protease (FXIa) that contributes to hemostasis by activating factor IX (FIX). In the original cascade model of coagulation, FXI is converted to FXIa by factor XIIa (FXIIa), a component, along with prekallikrein and high-molecular-weight kininogen (HK), of the plasma kallikrein-kinin system (KKS). | |||
TMPH-03268 |
Coagulation factor XI Protein, Rat, Recombinant (His & Myc)
Coagulation factor XI,F11 |
Rat | E. coli |
Coagulation factor XI Protein, Rat, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPJ-00301 |
Coagulation Factor X Protein, Human, Recombinant (hFc)
Stuart-Prower factor,Stuart factor,Coagulation fact... |
Human | HEK293 Cells |
F10, also known as Coagulation factor X, belongs to the peptidase S1 family that is synthesized as a 488 amino acid (aa) with a signal peptide and a pro region (residues 1‑40). Both the intrinsic and extrinsic pathways activate Factor X to Xa, which consists of light (residues 41‑179) and heavy (residues 235‑488) chains linked by a disulfide bond. Coagulation factor X is initially synthesized in the liver. The two chains are formed from a single-chain precursor by the excision of two Arg residue... | |||
TMPJ-00707 |
Coagulation factor X/F10 Protein, Mouse, Recombinant (His)
Stuart factor,Coagulation factor X,F10 |
Mouse | HEK293 Cells |
Mouse coagulation factor X / F10 a member of the peptidase S1 family. The mature F10 is composed mostly of two EGF-like domains, one Gla gamma-carboxy-glutamate domain and one peptidase S1 domain. Factor Xa is a vitamin K-dependent plasma protease that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. The two chains of F10 are formed from a single-chain precursor by the excision of two Arg residues. A single-chain precursor is initiall... | |||
TMPY-01791 |
Coagulation Factor II Protein, Mouse, Recombinant (His)
Cf-2,coagulation factor II (thrombin),Cf2,FII |
Mouse | HEK293 Cells |
Coagulation Factor II Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 69.3 kDa and the accession number is P19221. | |||
TMPH-03106 |
Coagulation factor XII Protein, Pig, Recombinant (His)
HAF,Hageman factor,F12,Coagulation factor XII |
Sus scrofa (Pig) | E. coli |
Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. Coagulation factor XII Protein, Pig, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predic... | |||
TMPH-01107 |
Coagulation factor V Protein, Human, Recombinant (His & SUMO)
F5,Activated protein C cofactor,Coagulation factor ... |
Human | E. coli |
Coagulation factor V Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPY-01030 |
TFPI Protein, Human, Recombinant (His)
TFPI1,tissue factor pathway inhibitor (lipoprotein-associate... |
Human | HEK293 Cells |
TFPI Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.6 kDa and the accession number is P10646-1. | |||
TMPK-00993 |
Coagulation Factor III/Tissue Factor Protein, Canine, Recombinant (His)
Thromboplastin,CD142,TF,FLJ17960,TFA,F3,Coagulation... |
Canine | HEK293 Cells |
Tissue factor (also named Coagulation Factor III) is a cell surface glycoprotein responsible for initiating the extrinsic pathway of coagulation.Tissue factor is the primary cellular initiator of blood coagulation via interaction with coagulation factor VII. Aberrant expression of tissue factor is responsible for thrombosis during septic shock, atherosclerosis and cancer. | |||
TMPY-05083 |
Tissue Factor Protein, Human, Recombinant (aa 1-295, His)
coagulation factor 3,TF,TFA,coagulation fa... |
Human | Baculovirus Insect Cells |
Tissue Factor Protein, Human, Recombinant (aa 1-295, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 31 kDa and the accession number is P13726-1. | |||
TMPY-02537 |
Tissue Factor Protein, Human, Recombinant (hFc)
coagulation factor III,coagulation factor ... |
Human | HEK293 Cells |
Tissue Factor Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.8 kDa and the accession number is P13726. | |||
TMPY-06957 |
Tissue Factor Protein, Human, Recombinant (hFc & Avi), Biotinylated
TFA,coagulation factor 3,coagulation facto... |
Human | HEK293 Cells |
Tissue Factor Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 53.34 kDa and the accession number is P13726. | |||
TMPY-02318 |
Tissue Factor Protein, Rabbit, Recombinant (His)
coagulation factor III (thromboplastin, tissue fact... |
Rabbit | HEK293 Cells |
Tissue Factor Protein, Rabbit, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.4 kDa and the accession number is P24055. | |||
TMPH-01975 |
Prothrombin Protein, Human, Recombinant (His & SUMO)
Prothrombin,F2,Coagulation factor II |
Human | E. coli |
Prothrombin Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPY-03209 |
Tissue Factor Protein, Rat, Recombinant (His)
coagulation factor III (thromboplastin, tissue fact... |
Rat | HEK293 Cells |
Tissue Factor Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.2 kDa and the accession number is Q66HI4. | |||
TMPH-01974 |
Prothrombin Protein, Human, Recombinant (His)
F2,Coagulation factor II,Prothrombin |
Human | P. pastoris (Yeast) |
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Prothrombin Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 67.3 kDa and the accession number is P00734. | |||
TMPJ-00535 |
F13A Protein, Human, Recombinant (His)
F13A1,Coagulation Factor XIII A Chain,Transglutamin... |
Human | HEK293 Cells |
Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is composed of just 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium io... | |||
TMPY-05025 |
Thrombin Receptor Protein, Human, Recombinant (His)
TR,PAR1,HTR,coagulation factor II (thrombin) recept... |
Human | HEK293 Cells |
Thrombin Receptor Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 10.2 kDa and the accession number is A0A024RAP7. | |||
TMPH-01108 |
Factor VII Protein, Human, Recombinant (His & SUMO)
F7,Serum prothrombin conversion accelerator,Proconvertin, |
Human | E. coli |
Factor VII Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPY-00928 |
TFPI Protein, Mouse, Recombinant (His)
AW552122,A630013F22Rik,tissue factor pathway inhibitor (lipo... |
Mouse | HEK293 Cells |
TFPI Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31 kDa and the accession number is O54819-1. | |||
TMPY-01325 |
Tissue Factor Protein, Mouse, Recombinant (His)
Cf-3,AA409063,CD142,coagulation factor III (thrombo... |
Mouse | HEK293 Cells |
Tissue Factor Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.8 kDa and the accession number is A0A0R4J088. | |||
TMPY-04029 |
Protein C Protein, Mouse, Recombinant (His)
PC,PROC,protein C, inactivator of coagulation facto... |
Mouse | HEK293 Cells |
Protein C Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.1 kDa and the accession number is NP_032960.3. | |||
TMPH-03210 |
TFPI Protein, Rabbit, Recombinant (E. coli, His)
Lipoprotein-associated coagulation inhibitor,Extrin... |
Rabbit | E. coli |
Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. TFPI Protein, Rabbit, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 35.8 kDa and the accession number is P19761. | |||
TMPY-05179 |
TFPI Protein, Human, Recombinant (His), Biotinylated
TFI,TFPI1,EPI,LACI,tissue factor pathway inhibitor (lipoprot... |
Human | HEK293 Cells |
TFPI Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.6 kDa and the accession number is P10646-1. | |||
TMPH-03211 |
TFPI Protein, Rabbit, Recombinant (His)
TFPI,Lipoprotein-associated coagulation inhibitor,E... |
Rabbit | HEK293 Cells |
Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. TFPI Protein, Rabbit, Recombinant (His) is expressed in HEK293 mammalian cells with N-10xHis tag. The predicted molecular weight is 35.4 kDa and the accession number is P19761. | |||
TMPY-03880 |
Protein C Protein, Human, Recombinant (His)
PROC,APC,THPH4,protein C, inactivator of coagulation |
Human | HEK293 Cells |
Protein C Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.5 kDa and the accession number is P04070. | |||
TMPY-04830 |
GAS6 Protein, Mouse, Recombinant (His)
growth arrest-specific 6,Gas-6 |
Mouse | HEK293 Cells |
The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. GAS6 is a vitamin K-dependent protein, plays a role in the survival, proliferation, migration, differentiation, adhesion, and apoptosis of cells. The growth arrest-specific 6 (GAS6) has been implicated in systemic inflammation and coagulation. Growth arrest-specific 6 (GAS6), plays a role in tumor... | |||
TMPY-00021 |
PADI4 Protein, Human, Recombinant (His)
PADI5,PAD4,PDI4,peptidyl arginine deiminase, type IV,PAD,PDI... |
Human | Baculovirus Insect Cells |
Protein-arginine deiminase type-4, also known as HL-6 PAD, Peptidylarginine deiminase IV, Protein-arginine deiminase type I V and PADI4, is a cytoplasm and nucleus protein that belongs to the protein arginine deiminase family. PADI4 is expressed in CD34+stem cells in normal tissues, and many more CD34+ cells expressing PADI4 are present in tumour tissues. PADI4 post-translationally converts peptidylarginine to citrulline, a process called citrullination. Studies have demonstrated the high expres... | |||
TMPH-03070 |
TAP Protein, Ornithodoros moubata, Recombinant (His)
Tick anticoagulant peptide |
Ornithodoros moubata | P. pastoris (Yeast) |
TAP is a slow, tight-binding inhibitor of blood coagulation, specific for factor Xa. | |||
TMPH-03071 |
TAP Protein, Ornithodoros moubata, Recombinant (His & Myc & SUMO)
Tick anticoagulant peptide |
Ornithodoros moubata | E. coli |
TAP is a slow, tight-binding inhibitor of blood coagulation, specific for factor Xa. | |||
TMPH-00346 |
Limulus clotting factor C Protein, Carcinoscorpius rotundicauda, Recombinant (His)
Limulus clotting factor C |
Carcinoscorpius rotundicauda | E. coli |
This enzyme is closely associated with an endotoxin-sensitive hemolymph coagulation system which may play important roles in both hemostasis and host defense mechanisms. Its active form catalyzes the activation of factor B. Limulus clotting factor C Protein, Carcinoscorpius rotundicauda, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 42.2 kDa and the accession number is Q26422. | |||
TMPY-01718 |
Serpin B12 Protein, Mouse, Recombinant (His)
2300003F07Rik,4833409F13Rik,serpin peptidase inhibitor, clad... |
Mouse | Baculovirus Insect Cells |
Serpins are the largest and most diverse family of serine protease inhibitors which are involved in some fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. Most serpins are secreted and attain physiologic concentrations in the blood and extracellular fluids. Mouse SerpinB12 is a cytoplasm protein that belongs to the serpin family and Ov-serpin subfamily. It ... | |||
TMPH-02408 |
SPI Protein, Lentinula edodes, Recombinant (His)
Serine protease inhibitor |
Lentinula edodes | E. coli |
Serine protease inhibitor. Active against beta-trypsin and alpha-chymotrypsin with dissociation constants of 0.35 nM and 40 nM respectively. Inhibits factor XIa, but not other enzymes involved in coagulation and fibrinolysis. Does not inhibit subtilisin, lysyl endopeptidase, arginyl endopeptidase or papain. | |||
TMPJ-01282 |
Serpin B12 Protein, Human, Recombinant (His)
SERPINB12,Serine Protease Inhibitor-clade B12,Serpin B12 |
Human | HEK293 Cells |
Serpin B12 is a member of the serpin family. Serpins are the largest and most diverse family of serine protease inhibitors. Most serpins are secreted and attain physiologic concentrations in the blood and extracellular fluids. Serpin B12 is expressed in many tissues, including brain, bone marrow, lymph node, heart, lung, liver, pancreas, testis, ovary, and intestine. Serpins are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysi... | |||
TMPH-00938 |
ANXA5 Protein, Human, Recombinant (His)
ANXA5,Annexin A5,Annexin V,Calphobindin I (CPB-I),ENX2,Endon... |
Human | P. pastoris (Yeast) |
This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. ANXA5 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 37.8 kDa and the accession number is P08758. | |||
TMPJ-01383 |
Serpin A10 Protein, Human, Recombinant (His)
PZI,Protein Z-Dependent Protease Inhibitor,Serpin A10,ZPI,PZ... |
Human | HEK293 Cells |
Serpin A10 is a secreted protein that belongs to the serpin family. It is predominantly expressed in the liver and secreted in the plasma. Its phosphorylation sites are present in the extracelllular medium. It inhibits factors Xa and XIa of the coagulation cascade in the presence of protein Z, calcium, and phospholipid. Mutations in SERPINA10 are associated with venous thrombosis. | |||
TMPK-00194 |
TFPI Protein, Human, Recombinant (His & Avi)
LACI,EPI,TFPI,convertin,TFI,TFPI1 |
Human | HEK293 Cells |
Oestrogens influence the pathophysiology and development of hormone-sensitive cancers, such as breast cancer. Tissue factor pathway inhibitor (TFPI) is a serine protease inhibitor of the extrinsic coagulation pathway and has recently been associated with breast cancer cell development. TFPI Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 32.1 kDa and the accession number is P10646-1. | |||
TMPK-00195 |
TFPI Protein, Human, Recombinant (His & Avi), Biotinylated
convertin,TFI,LACI,EPI,TFPI,TFPI1 |
Human | HEK293 Cells |
Oestrogens influence the pathophysiology and development of hormone-sensitive cancers, such as breast cancer. Tissue factor pathway inhibitor (TFPI) is a serine protease inhibitor of the extrinsic coagulation pathway and has recently been associated with breast cancer cell development. TFPI Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 32.1 kDa and the accession number is P10646-1. | |||
TMPH-03618 |
Clotting factor C Protein, Tachypleus tridentatus, Recombinant (His & Myc)
FC,Limulus factor C,Clotting factor C |
Tachypleus tridentatus | E. coli |
This enzyme is closely associated with an endotoxin-sensitive hemolymph coagulation system which may play important roles in both hemostasis and host defense mechanisms. Its active form catalyzes the activation of clotting factor B. Clotting factor C Protein, Tachypleus tridentatus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 33.8 kDa and the accession number is P28175. | |||
TMPH-00038 |
Thrombin-like enzyme contortrixobin Protein, Agkistrodon contortrix, Recombinant (His & Myc)
Snake venom serine protease,Thrombin-like enzyme contortrixo... |
Agkistrodon contortrix | E. coli |
Thrombin-like snake venom serine protease that cleaves beta chain of fibrinogen (FGB), releasing fibrinopeptide B. Has a coagulant activity activating blood coagulation factors V (F5) and XIII (F13A1). Thrombin-like enzyme contortrixobin Protein, Agkistrodon contortrix, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 32.4 kDa and the accession number is P82981. | |||
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