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Search Results for " cathepsin-d "

11

抑制剂 & 化合物

1

天然产物

6

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T37504L	Cathepsin D and E FRET Substrate acetate
	Cathepsin D and E FRET Substrate acetate 是组织蛋白酶 D 和 E 的荧光底物，但不适用于 B、H 或 L。Cathepsin D and E FRET Substrate acetate 可用于组织蛋白酶 D 和 E 研究的机理研究。
T37504	Cathepsin D and E FRET Substrate
	Mca-GKPILFFRL-Dpa-r-amide, FRET substrate for cathepsin D and E. Also cleaved by napsin A.
T16777	ROC-325	Apoptosis; Autophagy	Apoptosis; Autophagy
	ROC-325 是一种有效的口服活性自噬抑制剂，具有抗癌活性。 ROC-325 诱导肾细胞癌凋亡并表现出良好的特异性。
T12188	NB-360	BACE	Neuroscience
	NB-360 是一种有效的脑穿透性 BACE1 和 BACE2 抑制剂，对小鼠和人源 BACE1 和 BACE2 的 IC50 分别为 5、5 和 6 nM。 NB-360 对相关的天冬氨酰蛋白酶、胃蛋白酶、组织蛋白酶 E 和组织蛋白酶 D 具有出色的特异性。
T3695	Pepstatin 抑肽素,Pepstatin A,Pepsin Inhibitor S 735A,Ahpatinin C	Amino Acids and Derivatives; Proteasome; HIV Protease; Autophagy	Autophagy; Metabolism; Microbiology/Virology; Proteases/Proteasome; Ubiquitination
	Pepstatin (Pepsin Inhibitor S 735A) 是由放线菌类产生的特异性天冬氨酸蛋白酶抑制剂，可抑制 HIV 蛋白酶的活性。
T2639	LY2811376	Beta Amyloid; Beta-Secretase; BACE	Neuroscience
	LY2811376 是可口服的非肽段β-secretase (BACE1)抑制剂，IC50=239 nM-249 nM，能够降低 Aβ 蛋白的分泌，EC50=300 nM。
T76614	H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH
	H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH 是一种水溶性多肽，可用作组织蛋白酶 D、胃蛋白酶及其前体的底物，并在生化分析中具有潜在应用价值。
T27595	Imarikiren HCl TAK-272 hydrochloride,TAK-272 HCl. Imarikiren HCl \|,TAK272,TAK 272,TAK-272	Others	Others
	Imarikiren is a potent, selective and orally active direct renin inhibitor. TAK-272 shows potent inhibitory activity against human renin (IC50 = 2.1 nM) in hPRA assay and excellent selectivity against other aspartic proteases, such as cathepsin D (IC50 >
T37661	LY 2886721 Hydrochloride	Others	Others
	Potent and selective β-secretase (BACE) inhibitor (IC50 values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively). Displays >5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin and renin. Inhibits Aβ1-40 and Aβ1-42 production in cells expressing mutated APP. Reduces hippocampal and cortical Aβ and sAPPβ levels in an Alzheimer's disease mouse model.
T83679	Parasin I (catfish) TFA
	Parasin I是来自鲶鱼(P. asotus)组蛋白H2A N端区域的一种抗微生物肽片段，参与宿主防御。它通过在受伤P. asotus的皮肤黏膜中的cathepsin D从组蛋白H2A形成。Parasin I对多种革兰氏阳性和阴性细菌以及真菌具有活性（MICs分别为1-2, 1-4, 和1-2 µg/ml）。
T13434	β-Secretase Inhibitor IV	Others	Others
	β-Secretase Inhibitor IV is a potent, cell-active inhibitor of BACE-1(IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively).

化合物

Cathepsin D and E FRET Substrate acetate

Cat.No: T37504L

Cathepsin D and E FRET Substrate

Cat.No: T37504

Cat.No: T16777

Target: Apoptosis, Autophagy

Cat.No: T12188

Target: BACE

Cat.No: T3695

Synonym: 抑肽素,Pepstatin A,Pepsin Inhibitor S 735A,Ahpatinin C

Target: Amino Acids and Derivatives, Proteasome, HIV Protease, Autophagy

Cat.No: T2639

Target: Beta Amyloid, Beta-Secretase, BACE

H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH

Cat.No: T76614

Cat.No: T27595

Synonym: TAK-272 hydrochloride,TAK-272 HCl. Imarikiren HCl |,TAK272,TAK 272,TAK-272

Target: Others

LY 2886721 Hydrochloride

Cat.No: T37661

Target: Others

Parasin I (catfish) TFA

Cat.No: T83679

β-Secretase Inhibitor IV

Cat.No: T13434

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T8709	Nandrolone phenylpropionate Nandrolone phenpropionate,苯丙酸诺龙	Androgen Receptor	Endocrinology/Hormones
	Nandrolone phenylpropionate (Nandrolone phenpropionate) 是一种合成代谢类固醇，是一种 19-nortestosterone 的衍生物。它能够促进蛋白质合成，用于缓解组织分解代谢，可以用于骨质疏松症和特纳综合征的研究。

天然产物

Nandrolone phenylpropionate

Cat.No: T8709

Synonym: Nandrolone phenpropionate,苯丙酸诺龙

Target: Androgen Receptor

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02450	Cathepsin D Protein, Human, Recombinant (His) HEL-S-130P,CLN10,cathepsin D,CPSD	Human	HEK293 Cells
	Cathepsin D Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44 kDa and the accession number is P07339.
TMPY-00733	Cathepsin D Protein, Mouse, Recombinant (His) CatD,CD,cathepsin D	Mouse	HEK293 Cells
	Cathepsin D Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44.4 kDa and the accession number is P18242.
TMPH-03261	Cathepsin D Protein, Rat, Recombinant (His & Myc) Ctsd,Cathepsin D	Rat	E. coli
	Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Cathepsin D Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 45.2 kDa and the accession number is P24268.
TMPH-00437	Cathepsin D Protein, Cricetulus griseus, Recombinant (His & SUMO) Ctsd,Cathepsin D	Chinese hamster	E. coli
	N/A. Cathepsin D Protein, Cricetulus griseus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 53.3 kDa and the accession number is G3I4W7.
TMPY-00729	Cystatin D Protein, Human, Recombinant (His) CST5,MGC71922,cystatin D	Human	HEK293 Cells
	Cystatins are natural inhibitors of papain-like (family C1) and legumain-related (family C13) cysteine peptidases. The mammalian cystatin superfamily members are of three major types, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. As a member of type 2 cystatin, cystatin D is a single-domain protein and also has cysteine residues that form disulfide bridges. In contrast with the wider distribution of all the other family 2 cystatins, cystatin D is tissue-restricte...
TMPJ-00845	CTSE Protein, Human, Recombinant (His) CTSE,Cathepsin E	Human	HEK293 Cells
	Cathepsin E (CTSE) is a gastric aspartyl protease that functions as a disulfide-linked homodimer. It is a member of the Peptidase C1 family, and has a specificity similar to that of Pepsin A and Cathepsin D. CTSE is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome. It is expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. CTSE is an intrac...

重组蛋白

Cathepsin D Protein, Human, Recombinant (His)

Cat.No: TMPY-02450

Species: Human

Expression System: HEK293 Cells

Cathepsin D Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00733

Species: Mouse

Expression System: HEK293 Cells

Cathepsin D Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03261

Species: Rat

Expression System: E. coli

Cathepsin D Protein, Cricetulus griseus, Recombinant (His & SUMO)

Cat.No: TMPH-00437

Species: Chinese hamster

Expression System: E. coli

Cystatin D Protein, Human, Recombinant (His)

Cat.No: TMPY-00729

Species: Human

Expression System: HEK293 Cells

CTSE Protein, Human, Recombinant (His)

Cat.No: TMPJ-00845

Species: Human

Expression System: HEK293 Cells

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