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Search Results for " catalytic "

Targets Recommended: Others

127

抑制剂 & 化合物

17

天然产物

122

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T50029	G6Pase catalytic subunit 1 inhibitor 1 2-((2,2-Dibenzylhydrazineylidene)methyl)pyridine,2-[(1E)-(dibenzylhydrazin-1-ylidene)methyl]pyridine	Others	Others
	2-((2,2-Dibenzylhydrazineylidene)methyl)pyridine (2-[(1E)-(dibenzylhydrazin-1-ylidene)methyl]pyridine) 是一种杂环化合物。它可以抑制单胺氧化酶，导致体内单胺水平升高；也可以抑制腺苷脱氨酶，导致体内腺苷水平升高；还可以可以增加某些神经递质的活性，包括血清素和多巴胺。
T12189	NBDHEX	Apoptosis; Glutathione Peroxidase; Autophagy	Apoptosis; Autophagy; Metabolism
	NBDHEX 是一种谷胱甘肽 S-转移酶 P1-1 抑制剂，也是晚期自噬抑制剂。它诱导肿瘤细胞凋亡，通过抑制 GST 的催化活性，避免抑制剂被特异性泵从细胞中排出，以及破坏 GSTP1-1和关键信号传导因子之间的相互作用，从而起到抗癌的作用。
T9884	EN523	Others	Others
	EN523 靶向 K48 泛素特异性去泛素酶 OTUB1 中的非催化变构半胱氨酸 C23。
T14505	BAY-524	Others	Others
	BAY524 是Bub1抑制剂，当 2 mM ATP 时，其IC50=450 nM。
T5363	Tempo 2,2,6,6-四甲基哌啶氧化物,2,2,6,6-Tetramethylpiperidinooxy	Free radical scavengers; Reactive Oxygen Species; DNA/RNA Synthesis; Mitochondrial Metabolism	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	Tempo (2,2,6,6-Tetramethylpiperidinooxy) 可用作自由基清除剂、有机合成中的试剂和电子自旋共振光谱中的结构探针。它可在催化循环中使超氧化物歧化，也可诱导DNA 链断裂。
T39341	FCPR03	PDE	Metabolism
	FCPR03 是一种特异性磷酸二酯酶 4 (PDE4) 抑制剂，对 PDE4B1、PDE4D7 和 PDE4 催化结构域的 IC50 分别为 31 nM、47 nM 和 60 nM。 FCPR03 具有神经保护、抗炎和抗抑郁样作用。
T15069	DBCO-PEG4-Biotin ADIBO-NH-PEG2-Biotin	Others	Others
	DBCO-PEG4-Biotin (ADIBO-NH-PEG2-Biotin) 是一种 azadibenzocyclooctyne-biotin 衍生物，含有生物素基团和 4 个 PEG。DBCO-PEG4-Biotin 是一种用途广泛的生物素酰化试剂，能通过无铜催化烷基叠氮化反应 (SPAAC) 将生物素的一部分引入叠氮标记的生物分子中。
T9961	L82-G17	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	L82-G17 是人体细胞中的一种非竞争性 LigI 选择性抑制剂，可用作 LigI 的催化活性和细胞功能的探针。
T5461	GNE-6640	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	GNE 6640 是一种选择性泛素特异性肽酶 7(USP7)的非共价抑制剂，其对全长USP7、USP7 催化结构域、全长USP43 以及 Ub-MDM2 的IC50值分别为 0.75 μM、0.43 μM、20.3 μM 和 0.23 μM。
T33795	3-OMFP Cyclohexylammonium salt OMFP Cyclohexylammonium salt	Others	Others
	3-OMFP Cyclohexylammonium salt (OMFP Cyclohexylammonium salt) 是 PTEN 抑制研究的底物，可用来测定CDC25B催化结构域的酶活性。
T8864	Thymidylate Kinase Inhibitor, YMU1	Others	Others
	YMU1 是一种选择性抑制剂，特异性作用于人胸苷酸激酶 (IC50: 610 nM) 。
T2661	TGX-221 TGX221	PI3K	PI3K/Akt/mTOR signaling
	TGX-221 是一种选择性的、高效的、细胞膜渗透的 PI3K p110β 抑制剂，常用于研究癌症。
T60169	BLU0588	Others	Others
	BLU0588是一种选择性的PRKACA 抑制剂。BLU0588以1nM 的 IC50 抑制PRKACA 催化活性。
T5097	Ezatiostat TER199(free base),TLK199	Apoptosis; Glutathione Peroxidase; GST	Apoptosis; Metabolism; oxidation-reduction
	Ezatiostat (TER199(free base)) 是一种谷胱甘肽的三肽类似物，也是一种选择性的口服活性的谷胱甘肽 S-转移酶 P1-1 (GSTP1) 抑制剂。它通过抑制GSTP1导致 JNK 激活，刺激淋巴细胞生成和骨髓祖细胞增殖，可研究骨髓增生异常综合症。
T22380	Nor-benzetimide 3-苯基-[3,4-联哌啶]-2,6-二酮	Others; AChR	Neuroscience; Others
	Norbenzetimide 是 Benzetimide 的主要代谢产物。Benzetimide 是一种mAChR 拮抗剂，具有抗胆碱能活性。
T9262	MAT2A inhibitor 4	Others; Methionine Adenosyltransferase (MAT)	Chromatin/Epigenetic; Others
	MAT2A inhibitor 4 是一种甲硫氨酸 S- 腺苷转移酶 -2 催化亚基的抑制剂，可用于研究癌症。
T15351	FT827	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	FT827 是选择性泛素特异性蛋白酶 7（USP7）共价抑制剂（Ki=4.2 µM，Kd=7.8 μM），靶向 USP7 的自抑制载脂蛋白形式的催化中心,可用于研究癌症。
T22086	HA 155 Autotaxin Inhibitor IV	PDE	Metabolism
	HA 155 (Autotaxin Inhibitor IV) 是一种基于硼酸的化合物，通过选择性结合其催化苏氨酸来抑制 ATX，IC50 为 5.7 nM。
T1994	Pictilisib RG7321,GDC-0941	Apoptosis; PI3K; Autophagy	Apoptosis; Autophagy; PI3K/Akt/mTOR signaling
	Pictilisib (GDC-0941) 是一种PI3Kα/δ抑制剂，IC50为 3 nM。它对110β和 p110γ 具有适度的选择性，分别为11倍和25倍。
T28416	PIK-108 PIK 108,PIK108	PI3K	PI3K/Akt/mTOR signaling
	PIK-108 是选择性的、变构的、非 ATP 竞争性的 p110β/p110δ 抑制剂。
T14073	A-485	Epigenetic Reader Domain; Histone Acetyltransferase	Chromatin/Epigenetic
	A-485 是 p300/CBP 的一种选择性催化抑制剂，对 p300和 CBP 组蛋白乙酰转移酶的 IC50值分别为 9.8 和 2.6 nM。
T23819	Braco-19 trihydrochloride BRAC-O19,BRACO19 hydrochloride,BRACO19 3HCl,BRACO 19,BRACO19 HCl	Telomerase	DNA Damage/DNA Repair
	Braco-19 trihydrochloride (BRACO19 3HCl) 是一种端粒酶抑制剂，可阻止端粒酶的加帽和催化作用。 Braco-19 trihydrochloride 抑制 HAdV 病毒复制。
T6326	BMS-345541 BMS-345541 free base,IKK Inhibitor III,BMS345541	IκB/IKK	NF-κB
	BMS-345541 (IKK Inhibitor III) 是选择性的 IKK 催化亚基 IKK-1 和 IKK-2 抑制剂，抑制 IKK-2 (IC50=0.3 nM) 和 IKK-1 (IC50=4 nM)。它与 IKK 的变构位点结合。
T1894	Idelalisib 艾代拉里斯,GS-1101,CAL-101	PI3K; Autophagy	Autophagy; PI3K/Akt/mTOR signaling
	Idelalisib (GS-1101) 是 PI3K 催化亚基 p110δ 的小分子抑制剂，IC50为 2.5 nM，对 p110δ 的选择性是 p110α/β/γ 的 40 到 300 倍。
T7541	PTP inhibitor 1 PTP Inhibitor II,alpha-溴-4-甲氧基苯乙酮	Phosphatase	Metabolism
	PTP inhibitor 1 是蛋白酪氨酸磷酸酶 (PTP) 抑制剂，具有抗血管生成作用。
T6324	(E/Z)-BIX02188 334949-59-6	ERK; MEK; TGF-beta/Smad	MAPK; Stem Cells
	BIX02188 是一种特异性 MEK5 抑制剂 (IC50: 4.3 nM)，也抑制 ERK5 催化活性 (IC50: 810 nM)，并且不抑制密切相关的激酶 MEK1/2、JNK2 和 ERK2。
T3623	Cobimetinib 可美替尼,考比替尼,RG7420,XL518,GDC-0973	Apoptosis; MEK	Apoptosis; MAPK
	Cobimetinib (GDC-0973) 是一种可口服的 MEK1选择性抑制剂，抑制MEK1的IC50为4.2 nM。
T67844	RBN-3143	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	RBN-3143 是有效的 NAD+ 竞争性催化 PARP14 抑制剂 (IC50= 4 nM)。 RBN-3143 可以抑制 PARP14 介导的 ADP-核糖基化，并稳定细胞系中的 PARP14。 RBN-3143 可用于肺部炎症研究。
T8813	Tetrakis (4-carboxyphenyl) porphyrin 中-四(4-羧基苯基)卟吩,TCPP,Tetracarboxyphenylporphine	Others	Others
	Tetrakis (4-carboxyphenyl) porphyrin (TCPP) 是一种金属去除剂。
T39217	PKA-IN-1	PKA	Tyrosine Kinase/Adaptors
	PKA-IN-1 是一种具有选择性和有效性的 cyclic AMP 依赖性蛋白激酶 (PKA) 催化亚基 (cAK) 抑制剂（IC50 ： 0.03 μM）。PKA-IN-1 可用于研究免疫系统疾病。
T14052	5-IAF 5-Iodoacetamidofluorescein
	5-IAF 是吲哚乙酰胺的一种荧光素衍生物，是一种荧光探针，可用来标记蛋白质和其他含有游离硫醇（半胱氨酸侧链）。5-IAF 可标记狗肾脏Na,K-ATP 酶的催化（α）亚单位。
T16333	NKY80 Adenylyl cyclase type V Inhibitor	Adenylyl cyclase	Neuroscience
	NKY80 调节心脏和肺组织中的腺苷酸环化酶催化活性。 NKY80 是腺苷酸环化酶 V 型亚型的非竞争性抑制剂（IC50 值：V、III 和 II 型分别为 8.3 µM、132 µM 和 1.7 mM）。
Fr14395	2,2'-Bipyridine	Others	Others
	2,2'-Bipyridine 是一种独特的生物活性天然产物分子支架，常用于许多螯合配体的核心结构。2,2'-Bipyridine 在催化中心的排列中起到桥梁的作用。2,2'-Bipyridine 具有良好的氧化还原稳定性和升糖活性。
T33631	Neocuproine Neocuproin	Others	Others
	Neocuproine 是一种铜（I）螯合剂，可增强电场刺激引起的输精管收缩的嘌呤能成分，常被用作配位试剂和铜离子检测剂。Neocuproine 与铜离子形成稳定的络合物，并可在某些化学反应和分析方法中起到催化作用。Neocuproine 作为铁和钴上的氧化还原活性配体平台，对NSC34细胞氧化损伤的保护作用。
T37571	4-Methylumbelliferyl-β-D-Glucopyranoside MU-GLU,4-MUG,4-MU-GLU,4-MU-β-Gluc,4-甲基伞形酮酰-Β-D-吡喃葡糖酸苷	Others	Others
	4-Methylumbelliferyl-β-D-Glucopyranoside (4-MU-GLU) 是β-glucosidase 的荧光底物，可用于β-glucosidase 活性的测定，期间释放出高荧光的 4-methylumbelliferyl (4-MU)，发射波长为 445-454 nm。4-MU 激发波长值与 pH 值有关，在 pH 值为 4.6、7.4 和 10.4 时分别为 330、370 和 385 nm。
T23046	N-tert-butyl-α-Phenylnitrone (Z)-N-benzylidene-2-Methylpropan-2-aMine oxide,N-叔丁基-α-苯基硝酮	ROS; COX	Immunology/Inflammation; Neuroscience
	N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) 是基于硝酮的自由基清除剂，可形成一氧化氮自旋加合物。它可以穿透血脑屏障，抑制 COX2的催化活性，有 ROS 清除、抗炎、神经保护、抗衰老和抗糖尿病的作用。
T60278	Tyrosinase-IN-2	Tyrosinase	Proteases/Proteasome
	Tyrosinase-IN-2 (compound 67) 是一种有效的酪氨酸酶抑制剂。酪氨酸酶是一种含铜金属酶，负责黑色素生物合成和酶促褐变中的限速催化步骤。Tyrosinase-IN-2 具有研究皮肤美白剂和食品防腐剂的潜力。
T11807	L002	Others; Histone Acetyltransferase; STAT	Chromatin/Epigenetic; JAK/STAT signaling; Others; Stem Cells
	L002 是一种细胞可渗透的，可逆特定性乙酰转移酶 p300(KAT3B)抑制剂，IC50为 1.98 μM。它结合乙酰辅酶 A 口袋并竞争性抑制 FATp300 催化结构域，阻断组蛋白乙酰化和 p53 乙酰化，且抑制 STAT3 激活，有用于高血压引起的心脏肥大和纤维化的研究潜力。
T60130	USP5-IN-1	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	USP5-IN-1 (compound 64) 是一种有效的去泛素酶USP5抑制剂，与 USP5 ZnF UBD 结合，KD 值为 2.8 μM。USP5-IN-1对九种含有结构相似的 ZnF UBD 结构域的蛋白质具有选择性。USP5-IN-1 抑制 USP5 对双泛素底物的催化裂解。
T27453	GSK1733953A DG70	Antibacterial	Microbiology/Virology
	GSK1733953A 可作为一种小分子结核分枝杆菌呼吸抑制剂，对 MenG 活性有抑制作用，IC50 值为 2.6 ± 0.6 μM。GSK1733953A 是一种具有选择性的联苯苯甲酰胺，对结核分枝杆菌去甲基萘醌甲基转移酶的催化甲基化有抑制作用，对结核分枝杆菌H4Rv的MIC为8.37 μg/ml，对耐药菌株的MIC为1.2至9.6 μg/ml。GSK1733953A 是治疗结核病的候选化合物。
T7084	2-Bromo-4'-hydroxyacetophenone SHP-1 Inhibitor II,PTP Inhibitor I,α-Bromo-4-hydroxyacetophenone,4-Hydroxyphenacyl bromide,2-溴-4'-羟基苯乙酮	Phosphatase	Metabolism
	2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I) 是一种PTP1B 的有效抑制剂，其Ki=42 μM。
T63049	CHD1Li 6.11	Others	Others
	CHD1Li 6.11 是一种致癌 CHD1L 的有效抑制剂，能够作用于 cat-CHD1L 重组蛋白 (IC50: 3.3 μM)。CHD1Li 6.11 是一种口服具有活力的抗肿瘤剂，明显减少由分离的准间充质细胞 (M 表型) 产生的 CRC 异种移植物的肿瘤体积，这些细胞具有增强的致瘤特性。
T25893	NU/ICRF 500	Others	Others
	NU/ICRF 500 is a novel anthracenyl-amino acid catalytic inhibitor of topoisomerase II.
T29196	YU142670 YU 142670,YU-142670	Others	Others
	YU142670 is a selective inhibitor of OCRL1/INPP5F and OCRL2/INPP5B by targeting OCRL catalytic domain.
T70465	Mf 268	Others	Others
	Mf 268 is a pseudo-reversible carbamate-type inhibitor which interacts with the catalytic and regulatory anionic site of the enzyme.
T70591	PF1070A	Others	Others
	PF1070A is a natural cyclic tetrapeptide HDAC Inhibitor through the inhibition of PfHDAC1 catalytic activity, potently inducing the synthesis of metallothionein.
T25140	BCH 2763 BCH2763,BCH-2763	Others	Others
	BCH 2763 is an effective, selective bifunctional thrombin inhibitor that blocks both the anion binding exosite and the active catalytic site.
T11552	hDDAH-1-IN-1	Others	Others
	hDDAH-1-IN-1 is a selective non-amino acid catalytic site inhibitor of human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1) (Ki: 18 μM).
T27145	Demethoxyviridin DMV	Others	Others
	Demethoxyviridin is a potent inhibitor of mammalian Ptdlns 3-kinase, it binds to the catalytic subunit (p110) of the enzyme. Demethoxyviridin is also an antifungal agent.
T61950	UIAA-II-232	Others	Others
	UIAA-II-232 (compound 19b) 是有效的DNA 促旋酶催化抑制剂（IC50= 3.5 μM）。

化合物

G6Pase catalytic subunit 1 inhibitor 1

Cat.No: T50029

Synonym: 2-((2,2-Dibenzylhydrazineylidene)methyl)pyridine,2-[(1E)-(dibenzylhydrazin-1-ylidene)methyl]pyridine

Target: Others

Cat.No: T12189

Target: Apoptosis, Glutathione Peroxidase, Autophagy

Cat.No: T9884

Target: Others

Cat.No: T14505

Target: Others

Cat.No: T5363

Synonym: 2,2,6,6-四甲基哌啶氧化物,2,2,6,6-Tetramethylpiperidinooxy

Target: Free radical scavengers, Reactive Oxygen Species, DNA/RNA Synthesis, Mitochondrial Metabolism

Cat.No: T39341

Target: PDE

DBCO-PEG4-Biotin

Cat.No: T15069

Synonym: ADIBO-NH-PEG2-Biotin

Target: Others

Cat.No: T9961

Target: DNA/RNA Synthesis

Cat.No: T5461

Target: DUB

3-OMFP Cyclohexylammonium salt

Cat.No: T33795

Synonym: OMFP Cyclohexylammonium salt

Target: Others

Thymidylate Kinase Inhibitor, YMU1

Cat.No: T8864

Target: Others

Cat.No: T2661

Synonym: TGX221

Target: PI3K

Cat.No: T60169

Target: Others

Cat.No: T5097

Synonym: TER199(free base),TLK199

Target: Apoptosis, Glutathione Peroxidase, GST

Nor-benzetimide

Cat.No: T22380

Synonym: 3-苯基-[3,4-联哌啶]-2,6-二酮

Target: Others, AChR

MAT2A inhibitor 4

Cat.No: T9262

Target: Others, Methionine Adenosyltransferase (MAT)

Cat.No: T15351

Target: DUB

Cat.No: T22086

Synonym: Autotaxin Inhibitor IV

Target: PDE

Cat.No: T1994

Synonym: RG7321,GDC-0941

Target: Apoptosis, PI3K, Autophagy

Cat.No: T28416

Synonym: PIK 108,PIK108

Target: PI3K

Cat.No: T14073

Target: Epigenetic Reader Domain, Histone Acetyltransferase

Braco-19 trihydrochloride

Cat.No: T23819

Synonym: BRAC-O19,BRACO19 hydrochloride,BRACO19 3HCl,BRACO 19,BRACO19 HCl

Target: Telomerase

Cat.No: T6326

Synonym: BMS-345541 free base,IKK Inhibitor III,BMS345541

Target: IκB/IKK

Cat.No: T1894

Synonym: 艾代拉里斯,GS-1101,CAL-101

Target: PI3K, Autophagy

PTP inhibitor 1

Cat.No: T7541

Synonym: PTP Inhibitor II,alpha-溴-4-甲氧基苯乙酮

Target: Phosphatase

Cat.No: T6324

Synonym: 334949-59-6

Target: ERK, MEK, TGF-beta/Smad

Cat.No: T3623

Synonym: 可美替尼,考比替尼,RG7420,XL518,GDC-0973

Target: Apoptosis, MEK

Cat.No: T67844

Target: PARP

Tetrakis (4-carboxyphenyl) porphyrin

Cat.No: T8813

Synonym: 中-四(4-羧基苯基)卟吩,TCPP,Tetracarboxyphenylporphine

Target: Others

Cat.No: T39217

Target: PKA

Cat.No: T14052

Synonym: 5-Iodoacetamidofluorescein

Cat.No: T16333

Synonym: Adenylyl cyclase type V Inhibitor

Target: Adenylyl cyclase

2,2'-Bipyridine

Cat.No: Fr14395

Target: Others

Cat.No: T33631

Synonym: Neocuproin

Target: Others

4-Methylumbelliferyl-β-D-Glucopyranoside

Cat.No: T37571

Synonym: MU-GLU,4-MUG,4-MU-GLU,4-MU-β-Gluc,4-甲基伞形酮酰-Β-D-吡喃葡糖酸苷

Target: Others

N-tert-butyl-α-Phenylnitrone

Cat.No: T23046

Synonym: (Z)-N-benzylidene-2-Methylpropan-2-aMine oxide,N-叔丁基-α-苯基硝酮

Target: ROS, COX

Tyrosinase-IN-2

Cat.No: T60278

Target: Tyrosinase

Cat.No: T11807

Target: Others, Histone Acetyltransferase, STAT

Cat.No: T60130

Target: DUB

Cat.No: T27453

Synonym: DG70

Target: Antibacterial

2-Bromo-4'-hydroxyacetophenone

Cat.No: T7084

Synonym: SHP-1 Inhibitor II,PTP Inhibitor I,α-Bromo-4-hydroxyacetophenone,4-Hydroxyphenacyl bromide,2-溴-4'-羟基苯乙酮

Target: Phosphatase

Cat.No: T63049

Target: Others

Cat.No: T25893

Target: Others

Cat.No: T29196

Synonym: YU 142670,YU-142670

Target: Others

Cat.No: T70465

Target: Others

Cat.No: T70591

Target: Others

Cat.No: T25140

Synonym: BCH2763,BCH-2763

Target: Others

Cat.No: T11552

Target: Others

Demethoxyviridin

Cat.No: T27145

Synonym: DMV

Target: Others

Cat.No: T61950

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T5855	Edrophonium chloride	AChE	Neuroscience
	Edrophonium chloride 是一种乙酰胆碱酯酶抑制剂，可通过特异性结合其催化位点来防止神经递质乙酰胆碱的分解。
T8072	S-Methyl-L-cysteine S-甲基-L-半胱氨酸,S-Methylcysteine	Antioxidant; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	S-Methyl-L-cysteine (S-Methylcysteine) 是一种催化抗氧化系统中甲硫氨酸硫氧化物还原酶 A 的作用底物，是一种天然产物，具有抗氧化、神经保护及减肥的功效。
T6830	Epoxomicin BU-4061T,BU-4061T,Aids010837,环氧酶素	Apoptosis; Proteasome	Apoptosis; Proteases/Proteasome; Ubiquitination
	Epoxomicin (BU-4061T,Aids010837) 是一种含环氧酮的天然产物，可穿越血脑屏障，并具有很强的抗肿瘤和抗炎活性。它是一种选择性不可逆的蛋白酶体抑制剂，抑制类胰凝乳蛋白酶的活性。
T4839	Ac-Ala-OH N-Acetylalanine,N-Acetyl-L-alanine,N-乙酰-L-丙氨酸	Others; Endogenous Metabolite	Metabolism; Others
	Ac-Ala-OH (N-Acetyl-L-alanine) 是鸟嘌呤核苷酸结合蛋白G(I)/G(S)/G(O) γ -2亚基、髓鞘碱性蛋白、GTP-结合核蛋白 Ran、原肌球蛋白 α - 4链、HIV-1 Rev 结合蛋白2、Xaa-Pro 二肽酶、胸腺酶 β -10、肌动蛋白样蛋白3、丙氨酸转氨酶、丝氨酸/苏氨酸蛋白磷酸酶PP1 - β催化亚基、10 kda 热休克蛋白(线粒体)、钙调蛋白和 β -1-syntrophin 的底物。
T4858	4-Hydroxyphenylpyruvic acid 4-羟苯基丙酮酸,4-Hydroxyphenylpyruvic acid	Endogenous Metabolite	Metabolism
	4-Hydroxyphenylpyruvic acid 是一种苯丙氨酸代谢的中间产物，是一种酶抑制剂。
T70725	Motuporin	Others	Others
	Motuporin is an inhibitor of type-1 and type-2A protein phosphatase catalytic subunits (PP-1c and PP-2Ac).
TN4173	Guajadial C	Topoisomerase	DNA Damage/DNA Repair
	Guajadial C acts as a Top1 catalytic inhibitor and can delay Top1 poison-mediated DNA damage. It shows cytotoxicity against five human cancer cell lines.
TN5348	Guajadial F
	Guajadial F acts as a Top1 catalytic inhibitor and can delay Top1 poison-mediated DNA damage. Guajadial F shows cytotoxicity against five human cancer cell lines.
T14196	Alternariol	Others	Others
	Alternariol (AOH), a mycotoxin synthesized by Alternaria species, displays numerous therapeutic and biological effects, including phytotoxic, cytotoxic, anti-HIV, anti-cancer, and anti-microbial properties. It functions by inhibiting the catalytic activity of topoisomerase I and II enzymes.
TN4172	Guajadial B	Topoisomerase	DNA Damage/DNA Repair
	Guajadial B acts as a Top1 catalytic inhibitor and delays Top1 poison-mediated DNA damage. Guajadial B shows cytotoxicities against five human cancer cell lines, it is the most effective having an IC50 value of 150 nM toward A549 cells.
TN6514	2-Carboxybenzaldehyde
	The major peak of 2-Carboxybenzaldehyde reductase activity in human liver co-purifies with hAFAR protein. Sulphydryl substances and some proteins play important roles in preserving the molecular and catalytic properties of 2-Carboxybenzaldehyde reductase.
T40611	(E)-Dehydrodiconiferyl alcohol	Others	Others
	(E)-Dehydrodiconiferyl alcohol is a potent dual inhibitor of hCA IX and hCA XII, effectively impeding the catalytic activity of both carbonic anhydrase isoforms. Additionally, (E)-Dehydrodiconiferyl alcohol exerts inhibitory effects on the nuclear translocation of NF-κB in the connective tissue of the healing area.
T37055	Cytostatin	Others	Others
	Cytostatin is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 μg/ml, respectively) and B16 cells metastatic activity in mice. It induces apoptosis of FS3 mouse fibrosarcoma cells (IC50 = 3.1 μg/ml). Cytostatin potently and selectively inhibits protein phosphatase 2A (PP2A; IC50 = 29 nM against the catalytic subunit), while having no effect against PP1, PP2B, or PP5.
T72645	Norbatzelladine L	Others	Others
	Norbatzelladine L 是一种 Pdr5p 转运蛋白催化活性和功能活性的抑制剂。Norbatzelladine L 抑制 Pdr5p ATPase 活性，IC50值为 3.8 µM。Norbatzelladine L 具有抗真菌 (antifungal)、抗寄生虫 (antiparasitic)、抗病毒 (antiviral)、抗细菌 (antibacterial) 和抗肿瘤活性。
T16332	NKH477 Colforsin dapropate hydrochloride	NMDAR	Neuroscience
	NKH477 is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 shows an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute
T38108	Fulvic Acid	Antioxidant; PDE	Metabolism; oxidation-reduction
	Fulvic Acid 是一种来自土壤、沉积物或水生环境中微生物产生的腐殖质的天然产物，是一种首次青霉菌中分离出的酚酸和真菌代谢产物。Fulvic Acid 抑制淀粉样蛋白b (17-42) (AB17-42)二聚化，破坏预先形成的AB17-42三聚体，并结合到磷酸二酯酶5A (PDE5A)的催化位点，可以调节机体免疫系统，影响细胞的氧化状态，改善胃肠功能。Fulvic Acid 可作为氧化剂或还原剂，具有研究糖尿病等慢性炎症性疾病的潜力。
T35415	α-D-Glucose-1,6-bisphosphate (potassium salt hydrate)	Others	Others
	α-D-Glucose-1,6-bisphosphate is abis-phosphorylated derivative of α-D-glucose that has roles in carbohydrate metabolism.1It is the product of the reaction of glucose-1- or 6-phosphate with glucose-1,6-bisphosphate synthase (PGM2LI) in the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate.2It is also a cofactor for the bacterial enzyme phosphopentomutase.3,4α-D-Glucose-1,6-bisphosphate has been used in the study of carbohydrate metabolism. 1.Beitner, R.Regulation of carbohydrate metabol...

天然产物

Edrophonium chloride

Cat.No: T5855

Target: AChE

S-Methyl-L-cysteine

Cat.No: T8072

Synonym: S-甲基-L-半胱氨酸,S-Methylcysteine

Target: Antioxidant, Reactive Oxygen Species

Cat.No: T6830

Synonym: BU-4061T,BU-4061T,Aids010837,环氧酶素

Target: Apoptosis, Proteasome

Cat.No: T4839

Synonym: N-Acetylalanine,N-Acetyl-L-alanine,N-乙酰-L-丙氨酸

Target: Others, Endogenous Metabolite

4-Hydroxyphenylpyruvic acid

Cat.No: T4858

Synonym: 4-羟苯基丙酮酸,4-Hydroxyphenylpyruvic acid

Target: Endogenous Metabolite

Cat.No: T70725

Target: Others

Cat.No: TN4173

Target: Topoisomerase

Cat.No: TN5348

Cat.No: T14196

Target: Others

Cat.No: TN4172

Target: Topoisomerase

2-Carboxybenzaldehyde

Cat.No: TN6514

(E)-Dehydrodiconiferyl alcohol

Cat.No: T40611

Target: Others

Cat.No: T37055

Target: Others

Norbatzelladine L

Cat.No: T72645

Target: Others

Cat.No: T16332

Synonym: Colforsin dapropate hydrochloride

Target: NMDAR

Cat.No: T38108

Target: Antioxidant, PDE

α-D-Glucose-1,6-bisphosphate (potassium salt hydrate)

Cat.No: T35415

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02869	MMP-12 Protein, Human, Recombinant (catalytic domain) HME,ME,MMP-12,MME,matrix metallopeptidase 12	Human	E. coli
	Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis, and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases, and tumor invasion. Macrophage Metalloelastase, also known as Matrix metalloproteinase-12, Macrophage elastase, ...
TMPY-01186	Argonaute-2 Protein, Human, Recombinant (His) EIF2C2,argonaute RISC catalytic component 2,Argonau...	Human	Baculovirus Insect Cells
	Argonaute-2 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 99 kDa and the accession number is Q9UKV8.
TMPY-02130	Argonaute-2 Protein, Mouse, Recombinant (His) mKIAA4215,1110029L17Rik,2310051F07Rik,Ago2,argonaute RISC	Mouse	Baculovirus Insect Cells
	Argonaute-2 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 99 kDa and the accession number is Q8CJG0.
TMPY-02311	AGO3 Protein, Human, Recombinant (His) EIF2C3,argonaute RISC catalytic component 3	Human	Baculovirus Insect Cells
	Argonaute (Ago) protein family plays a key role in the RNA interference (RNAi) process in different insects including Lepidopteran. AGO3 also coexists and interacts with Armitage in the mitochondrial fraction. Furthermore, AGO3 acts in conjunction with the mitochondria-associated protein Zucchini to control the dynamic subcellular localization of Armitage between mitochondria and nuage in a Slicer-dependent fashion.
TMPH-01029	CAPN1 Protein, Human, Recombinant (His) CANPL1,CAPN1,Calpain-1 catalytic subunit,Micromolar...	Human	E. coli
	Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409'. CAPN1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 85.9 kDa and the accession number is P07384.
TMPH-00476	DNA-PKcs Protein, Dictyostelium discoideum, Recombinant (His & Myc) DNA-PKcs,DNA-PK catalytic subunit,dnapkcs,DNA-depen...	Dictyostelium discoideum	E. coli
	DNA-PKcs Protein, Dictyostelium discoideum, Recombinant (His & Myc) is expressed in E. coli.
TMPH-01031	CAPN2 Protein, Human, Recombinant (His) Calpain-2 catalytic subunit,Millimolar-calpain,Calp...	Human	E. coli
	Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs. CAPN2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 82...
TMPJ-00944	PPP1CC Protein, Human, Recombinant (His) PP-1G,Serine/Threonine-Protein Phosphatase PP1-Gamma Cat...	Human	E. coli
	Serine/Threonine-Protein Phosphatase PP1-Υ Catalytic Subunit (PPP1CC) is a member of the PPP phosphatase family. It is essential for cell division, participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. PPP1CC colocalizes with SPZ1 in the nucleus, with URI1 at mitochondrion, Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments. As a cofactor, PPP1CC binds one iron ion and one manganese ion per subunit.. In addition, PPP1C...
TMPH-02926	TRET Protein, Mouse, Recombinant (His & SUMO) Telomerase catalytic subunit,Telomerase reverse tra...	Mouse	E. coli
	TRET Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 54.1 kDa and the accession number is O70372.
TMPH-01857	PIK3CG Protein, Human, Recombinant (His & Myc) p120-PI3K,Phosphoinositide-3-kinase catalytic gamma...	Human	E. coli
	PIK3CG Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 35.4 kDa and the accession number is P48736.
TMPH-02098	PPP1CB Protein, Human, Recombinant (His) PPP1CB,Serine/threonine-protein phosphatase PP1-beta cat...	Human	E. coli
	PPP1CB Protein, Human, Recombinant (His) is expressed in E. coli.
TMPY-01308	AGO1 Protein, Human, Recombinant (His) EIF2C,GERP95,argonaute RISC catalytic component 1,E...	Human	Baculovirus Insect Cells
	Protein argonaute-1, also known as eukaryotic translation initiation factor 2C 1, EIF2C1, and AGO1, is a member of the argonaute family and ago subfamily. Protein argonaute-1 in humans is encoded by the EIF2C1 gene. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and argonaute 4. This genomic region is frequently lost in human cancers such as Wilms tumors, neuroblastoma, and carcinomas of the breast, liver, and colon. The human EIF...
TMPH-00499	PPP1CA Protein, Canine, Recombinant (His & Myc) PPP1CA,Serine/threonine-protein phosphatase PP1-alpha ca...	Canine	E. coli
	PPP1CA Protein, Canine, Recombinant (His & Myc) is expressed in E. coli.
TMPH-02186	TERT Protein, Human, Recombinant (His) Telomerase reverse transcriptase,Telomerase catalytic	Human	E. coli
	Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-de...
TMPY-02963	Calcineurin A/PPP3CA Protein, Human, Recombinant (His) CALNA1,CNA1,PPP2B,CALNA,CCN1,protein phosphatase 3, cata...	Human	Baculovirus Insect Cells
	PPP3CA, also known as protein phosphatase 2B, is a member of the PPP phosphatase family, PP-2B subfamily. It is the alpha catalytic subunit of protein phosphatase 2B (PP2B). PP2B is a holoenzyme that is comprised of a catalytic subunit associated with regulatory subunits. It is a calcium regulated enzyme that is activated by calmodulin and participates in the signaling cascades involved in development of the nervous, cardiovascular, and musculoskeletal systems. PPP3CA activates the T cells of th...
TMPY-02050	DDOST Protein, Human, Recombinant CDG1R,OST48,OKSWcl45,AGER1,OST,dolichyl-diphosphooligosaccha...	Human	E. coli
	The enzyme oligosaccharyltransferase (dolichyl-diphosphooligosaccharide-protein glycosyltransferase) (DDOST), or 48-kDa subunit (OST48) is one of the catalytic subunits in this complex, exerts a typical type I membrane topology, containing a large luminal domain, a hydrophobic transmembrane domain and a short cytosolic peptide tail. DDOST/OST48 catalyzes the transfer of a high-mannose oligosaccharide (GlcNac2Man9Glc3) from a dolichol-linked oligosaccharide donor (dolichol-P-GlcNac2Man9Glc3) onto...
TMPH-02096	PPP2CA Protein, Human, Recombinant (His & Myc) Serine/threonine-protein phosphatase 2A catalytic s...	Human	E. coli
	PPP2CA Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPY-03339	NAA10/ARD1 Protein, Human, Recombinant (His & GST) ARD1P,DXS707,ARD1,NATD,ARD1A,N(alpha)-acetyltransferase 10, ...	Human	Baculovirus Insect Cells
	NAA10/ARD1 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 54 kDa and the accession number is P41227.
TMPH-01390	G6PC Protein, Human, Recombinant (His & SUMO) Glucose-6-phosphatase alpha,G6PC1,Glucose-6-phosphatase,Gluc...	Human	E. coli
	Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels. G6PC Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 17.1 kDa and the accession number i...
TMPH-01171	CDK5 Protein, Human, Recombinant Serine/threonine-protein kinase PSSALRE,Cyclin-dependent-lik...	Human	E. coli
	CDK5 Protein, Human, Recombinant is expressed in E. coli.
TMPH-01389	G6PC Protein, Human, Recombinant (His) Glucose-6-phosphatase,Glucose-6-phosphatase catalytic	Human	P. pastoris (Yeast)
	Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels. G6PC Protein, Human, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 5.6 kDa and the accession number is P35575.
TMPY-04266	NAA10/ARD1 Protein, Human, Recombinant NAA10,ARD1,ARD1A,ARD1P,NATD,TE2,N(α)-acetyltransferase 10, N...	Human	Baculovirus Insect Cells
	NAA10/ARD1 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 26.6 kDa and the accession number is P41227.
TMPH-01734	METTL3 Protein, Human, Recombinant (His) METTL3,N6-adenosine-methyltransferase catalytic sub...	Human	E. coli
	METTL3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 70.4 kDa and the accession number is Q86U44.
TMPH-02110	SEC11C Protein, Human, Recombinant (His & SUMO) Microsomal signal peptidase 21 kDa subunit,SEC11-like protei...	Human	E. coli
	Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.
TMPH-02479	PRKAA1 Protein, Mouse, Recombinant (E. coli, His) 5'-AMP-activated protein kinase catalytic subunit a...	Mouse	E. coli
	PRKAA1 Protein, Mouse, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 39.8 kDa and the accession number is Q5EG47.
TMPH-02478	PRKAA1 Protein, Mouse, Recombinant (His) Prkaa1,Tau-protein kinase PRKAA1,Hydroxymethylglutaryl-CoA r...	Mouse	Baculovirus Insect Cells
	PRKAA1 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with N-6xHis tag. The predicted molecular weight is 65 kDa and the accession number is Q5EG47.
TMPH-02557	CAPN1 Protein, Mouse, Recombinant (His) CANP 1,Calpain-1 catalytic subunit,muCANP,CANPL1,Ca...	Mouse	E. coli
	Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-388' and 'His-410'.
TMPY-04125	PTP1B Protein, Human, Recombinant (His) protein tyrosine phosphatase, non-receptor type 1,PTP1B,PTPN...	Human	E. coli
	PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1B contains 1 tyrosine-protein p...
TMPY-02585	Acid sphingomyelinase/SMPD1 Protein, Mouse, Recombinant (His) aSMase,ASM,Zn-SMase,A-SMase,sphingomyelin phosphodiesterase ...	Mouse	Baculovirus Insect Cells
	Sphingomyelin phosphodiesterase 1 (SMPD1) , also known as ASM ( acid sphingomyelinase ), is a member of the acid sphingomyelinase family of enzymes. Three isoforms have been identified, isoform 1 is 631 amino acids (aa) in length as the pro form, while Isoform 2 and isoform 3 have lost catalytic activity. The active SMPD1 isoform 1 contains one saposin B-type domain that likely interacts with sphingomyelin, and a catalytic region. Human SMPD1 is 86% aa identical to mouse SMPD1. SMPD1 is a monome...
TMPY-00570	Alkaline Phosphatase/PLAP Protein, Human, Recombinant (His) ALPI,PALP,PLAP,PLAP-1,alkaline phosphatase, placental,IAP,AL...	Human	P. pastoris (Yeast)
	Most importantly, placental alkaline phosphatase (ALPP), an ectoenzyme that locates on cell surface with catalytic domains outside the plasma membrane and is overexpressed on many cancer cells, dephosphorylate the d-tyrosine phosphates on the surface of the magnetic nanoparticle and enable the magnetic nanoparticles to adhere selectively to the cancer cells, such as HeLa cells. Placental alkaline phosphatase (PLAP), encoded by the ALPP gene, is produced by the fetal side of the placenta.
TMPY-02801	PHGDH Protein, Human, Recombinant (His) phosphoglycerate dehydrogenase,HEL-S-113,3PGDH,NLS1,PHGDHD,P...	Human	E. coli
	PHGDH is a member of the D-isomer specific 2-hydroxyacid dehydrogenase family. This new family consists of D-isomer-stereospecific enzymes. The conserved residues in this family appear to be the residues involved in the substrate binding and the catalytic reaction, and thus to be targets for site-directed mutagenesis. A number of NAD-dependent 2-hydroxyacid dehydrogenases which seem to be specific for the D-isomer of their substrate have been shown to be functionally and structurally related. PH...
TMPY-02707	PAH Protein, Human, Recombinant (415 Asn/Asp, His) phenylalanine hydroxylase,PH,PKU1,PKU	Human	Baculovirus Insect Cells
	PAH (phenylalanine hydroxylase), also known as PH, belongs to the biopterin-dependent aromatic amino acid hydroxylase family. It contains 1 ACT domain, N-terminal region of PAH is thought to contain allosteric binding sites for phenylalanine and to constitute an "inhibitory" domain that regulates the activity of a catalytic domain in the C-terminal portion of the molecule. In humans, PAH is expressed both in the liver and the kidney, and there is some indication that it may be differentially reg...
TMPY-00203	LOXL2 Protein, Mouse, Recombinant (His) 1110004B06Rik,4930526G11Rik,9430067E15Rik,lysyl oxidase-like...	Mouse	HEK293 Cells
	Lysyl oxidase homolog 2, also known as Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2, Lysyl oxidase-related protein WS9-14 and LOXL2, is a secreted protein that belongs to the lysyl oxidase family. LOXL2 contains four SRCR domains. The lysyl oxidase family is made up of five members: lysyl oxidase (LOX) and lysyl oxidase-like 1-4 ( LOXL1, LOXL2, LOXL3, LOXL4 ). All members share conserved C-terminal catalytic domains that provide for lysyl oxidase or lysyl oxidase-like enzyme act...
TMPY-02543	PCNA Protein, Human, Recombinant (His) ATLD2,proliferating cell nuclear antigen	Human	Baculovirus Insect Cells
	Proliferating Cell Nuclear Antigen (PCNA) is a protein only expressed in normal proliferate cells and cancer cells. It is central to both DNA replication and repair. One of the well-established functions for PCNA is its role as the processivity factor for DNA polymerase delta and epsilon. PCNA tethers the polymerase catalytic unit to the DNA template for rapid and processive DNA synthesis. Two forms of PCNA exist in cells: (i) a detergent-insoluble trimeric form stably associated with the replic...
TMPY-04548	CDK4 Protein, Human, Recombinant (GST) CMM3,PSK-J3,cyclin-dependent kinase 4	Human	Baculovirus Insect Cells
	CDK4 is a member of the Ser/Thr protein kinase family. It is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of CDK4 is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). CDK4 was shown to be responsible for the phosphorylation of retinoblastoma gene product. CDK4 is the ser...
TMPY-02185	Coagulation factor XIII B/F13B Protein, Human, Recombinant (His) Coagulation factor 13,coagulation factor XIII, B polypeptide...	Human	HEK293 Cells
	Coagulation factor XIII B chain, also known as Fibrin-stabilizing factor B subunit, Protein-glutamine gamma-glutamyltransferase B chain, Transglutaminase B chain and F13B, is a secreted protein which contains 1 Sushi ( CCP / SCR ) domains. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have en...
TMPY-01104	Coagulation factor XI/F11 Protein, Human, Recombinant (His) coagulation factor 11,coagulation factor XI,FXI	Human	HEK293 Cells
	Factor XI (plasma thromboplastin antecedent) is a plasma glycoprotein, and a zymogen acting as a serine protease which participates in blood coagulation as a catalyst in the conversion of factor IX to factor IXa in the presence of calcium ions. It is an unusual dimeric protease, with structural features that distinguish it from vitamin K-dependent coagulation proteases. The factor XI is synthesized in the liver as a single polypeptide chain with a molecular weight estimated between 125 ~160 kDa ...
TMPY-03609	ATP5D Protein, Human, Recombinant (His) ATP synthase, H+ transporting, mitochondrial F1 complex, del...	Human	E. coli
	ATP5D is a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase consists of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon...
TMPH-02530	ATP5B Protein, Mouse, Recombinant (His & Myc & SUMO) ATP synthase F1 subunit beta,Atp5b,Atp5f1b,ATP synthase subu...	Mouse	E. coli
	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain ...
TMPH-00015	Abrin-d Protein, Abrus precatorius, Recombinant (His & Myc)	Abrus precatorius	E. coli
	The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA.; The B chain is a galactose-specific lectin that facilitates the binding of abrin to the cell membrane that precedes endocytosis.
TMPH-00516	StxA2 Protein, Enterobacteria phage 933W, Recombinant (E189K, His & Myc) Verotoxin 2 subunit A,Verocytotoxin 2 subunit A,Shiga-like t...	Enterobacteria phage 933W	E. coli
	The A subunit is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits. After endocytosis, the A subunit is cleaved by furin in two fragments, A1 and A2: A1 is the catalytically active fragment, and A2 is essential for holotoxin assembly with the B subunits.
TMPH-01665	TIMP3 Protein, Human, Recombinant (His) Tissue inhibitor of metalloproteinases 3,TIMP3,Protein MIG-5...	Human	E. coli
	Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
TMPY-02978	ABHD14B Protein, Human, Recombinant (His) CIB,abhydrolase domain containing 14B,HEL-S-299	Human	E. coli
	ABHD14B belongs to the AB hydrolase superfamily, ABHD14 family. It can be detected in spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocyte, heart, placenta, lung, liver, skeletal muscle, pancreas and kidney. ABHD14B has hydrolase activity towards p-nitrophenyl butyrate (in vitro) and may interact with TAF1. It may activate transcription. Recombinant human ABHD14B protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventi...
TMPY-03788	ATP1B1 Protein, Human, Recombinant (His) ATPase, Na+/K+ transporting, β 1 polypeptide,ATPase, Na+/K+ ...	Human	HEK293 Cells
	ATP1B1 belongs to the family of Na+/K+and H+/K+-ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. ATP1B1 is a subunit of Na+/K+-ATPase. Na+/K+-ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. Na+/K+-ATPase is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). ATP1B1 regulates, through assembly of alpha/beta heterodim...
TMPY-04557	PHKG1 Protein, Human, Recombinant (GST) phosphorylase kinase, γ 1 (muscle),phosphorylase kinase, gam...	Human	Baculovirus Insect Cells
	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform, also known as Phosphorylase kinase subunit gamma-1 and PHKG1, is a member of the protein kinase superfamily and CAMK Ser/Thr protein kinase family. PHKG1 is the catalytic member of a 16 subunit protein kinase complex that contains equimolar ratios of 4 subunit types. The complex is a crucial glycogenolytic regulatory enzyme. Muscle glycogenosis caused by phosphorylase kinase (Phk) deficiency may lead to exercise intolerance, ...
TMPJ-01309	PKI-Beta Protein, Human, Recombinant (His) PRKACN2,PKI-beta,PKI-β,cAMP-Dependent Protein Kinase Inhibit...	Human	E. coli
	cAMP-Dependent Protein Kinase Inhibitor β (PKI-β) is a member of the PKI family. As a member of the cAMP-dependent protein kinase inhibitor family,It has been shown that PKI-β is an extremely potent competitive inhibitor of cAMP-dependent protein kinase activity; this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. It may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and...
TMPH-03453	GPI3 Protein, S. cerevisiae, Recombinant (His & Myc) Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 su...	Saccharomyces cerevisiae	E. coli
	Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. GPI3 Protein, S. cerevisiae, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 49.8 kDa and the accession number is P32363.
TMPJ-01289	TIMP-4 Protein, Human, Recombinant (His) TIMP4,TIMP-4,Metalloproteinase inhibitor 4,Tissue inhibitor ...	Human	HEK293 Cells
	Metalloproteinase inhibitor 4 is an enzyme that in humans is encoded by the TIMP4 gene, belongs to the protease inhibitor I35 (TIMP) family. The protein complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.
TMPH-03326	MASP2 Protein, Rat, Recombinant (His) Mannan-binding lectin serine protease 2,MBL-associated serin...	Rat	Baculovirus Insect Cells
	Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase. MASP2 Protein, Rat, Recombinant (His) is expressed in Baculovirus insect cells with C-6xHis tag. The predicted molecular weight is 79.2 kDa and the accession number is Q9JJS8.
TMPK-01308	TAG-72 Protein, Canine, Recombinant (His) mRNA-methyltransferase,mRNA (guanine-N(7))-methyltransferase...	Canine	E. coli
	The guanine-N7 methyltransferase domain of vaccinia virus mRNA capping enzyme is a heterodimer composed of a catalytic subunit and a stimulatory subunit. Cap (guanine-N7) methylation is an essential step in eukaryal mRNA synthesis and a potential target for antiviral, antifungal, and antiprotozoal drug discovery.
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重组蛋白

MMP-12 Protein, Human, Recombinant (catalytic domain)

Cat.No: TMPY-02869

Species: Human

Expression System: E. coli

Argonaute-2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01186

Species: Human

Expression System: Baculovirus Insect Cells

Argonaute-2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02130

Species: Mouse

Expression System: Baculovirus Insect Cells

AGO3 Protein, Human, Recombinant (His)

Cat.No: TMPY-02311

Species: Human

Expression System: Baculovirus Insect Cells

CAPN1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01029

Species: Human

Expression System: E. coli

DNA-PKcs Protein, Dictyostelium discoideum, Recombinant (His & Myc)

Cat.No: TMPH-00476

Species: Dictyostelium discoideum

Expression System: E. coli

CAPN2 Protein, Human, Recombinant (His)

Cat.No: TMPH-01031

Species: Human

Expression System: E. coli

PPP1CC Protein, Human, Recombinant (His)

Cat.No: TMPJ-00944

Species: Human

Expression System: E. coli

TRET Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02926

Species: Mouse

Expression System: E. coli

PIK3CG Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01857

Species: Human

Expression System: E. coli

PPP1CB Protein, Human, Recombinant (His)

Cat.No: TMPH-02098

Species: Human

Expression System: E. coli

AGO1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01308

Species: Human

Expression System: Baculovirus Insect Cells

PPP1CA Protein, Canine, Recombinant (His & Myc)

Cat.No: TMPH-00499

Species: Canine

Expression System: E. coli

TERT Protein, Human, Recombinant (His)

Cat.No: TMPH-02186

Species: Human

Expression System: E. coli

Calcineurin A/PPP3CA Protein, Human, Recombinant (His)

Cat.No: TMPY-02963

Species: Human

Expression System: Baculovirus Insect Cells

DDOST Protein, Human, Recombinant

Cat.No: TMPY-02050

Species: Human

Expression System: E. coli

PPP2CA Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02096

Species: Human

Expression System: E. coli

NAA10/ARD1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-03339

Species: Human

Expression System: Baculovirus Insect Cells

G6PC Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01390

Species: Human

Expression System: E. coli

CDK5 Protein, Human, Recombinant

Cat.No: TMPH-01171

Species: Human

Expression System: E. coli

G6PC Protein, Human, Recombinant (His)

Cat.No: TMPH-01389

Species: Human

Expression System: P. pastoris (Yeast)

NAA10/ARD1 Protein, Human, Recombinant

Cat.No: TMPY-04266

Species: Human

Expression System: Baculovirus Insect Cells

METTL3 Protein, Human, Recombinant (His)

Cat.No: TMPH-01734

Species: Human

Expression System: E. coli

SEC11C Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02110

Species: Human

Expression System: E. coli

PRKAA1 Protein, Mouse, Recombinant (E. coli, His)

Cat.No: TMPH-02479

Species: Mouse

Expression System: E. coli

PRKAA1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02478

Species: Mouse

Expression System: Baculovirus Insect Cells

CAPN1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02557

Species: Mouse

Expression System: E. coli

PTP1B Protein, Human, Recombinant (His)

Cat.No: TMPY-04125

Species: Human

Expression System: E. coli

Acid sphingomyelinase/SMPD1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02585

Species: Mouse

Expression System: Baculovirus Insect Cells

Alkaline Phosphatase/PLAP Protein, Human, Recombinant (His)

Cat.No: TMPY-00570

Species: Human

Expression System: P. pastoris (Yeast)

PHGDH Protein, Human, Recombinant (His)

Cat.No: TMPY-02801

Species: Human

Expression System: E. coli

PAH Protein, Human, Recombinant (415 Asn/Asp, His)

Cat.No: TMPY-02707

Species: Human

Expression System: Baculovirus Insect Cells

LOXL2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00203

Species: Mouse

Expression System: HEK293 Cells

PCNA Protein, Human, Recombinant (His)

Cat.No: TMPY-02543

Species: Human

Expression System: Baculovirus Insect Cells

CDK4 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04548

Species: Human

Expression System: Baculovirus Insect Cells

Coagulation factor XIII B/F13B Protein, Human, Recombinant (His)

Cat.No: TMPY-02185

Species: Human

Expression System: HEK293 Cells

Coagulation factor XI/F11 Protein, Human, Recombinant (His)

Cat.No: TMPY-01104

Species: Human

Expression System: HEK293 Cells

ATP5D Protein, Human, Recombinant (His)

Cat.No: TMPY-03609

Species: Human

Expression System: E. coli

ATP5B Protein, Mouse, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-02530

Species: Mouse

Expression System: E. coli

Abrin-d Protein, Abrus precatorius, Recombinant (His & Myc)

Cat.No: TMPH-00015

Species: Abrus precatorius

Expression System: E. coli

StxA2 Protein, Enterobacteria phage 933W, Recombinant (E189K, His & Myc)

Cat.No: TMPH-00516

Species: Enterobacteria phage 933W

Expression System: E. coli

TIMP3 Protein, Human, Recombinant (His)

Cat.No: TMPH-01665

Species: Human

Expression System: E. coli

ABHD14B Protein, Human, Recombinant (His)

Cat.No: TMPY-02978

Species: Human

Expression System: E. coli

ATP1B1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03788

Species: Human

Expression System: HEK293 Cells

PHKG1 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04557

Species: Human

Expression System: Baculovirus Insect Cells

PKI-Beta Protein, Human, Recombinant (His)

Cat.No: TMPJ-01309

Species: Human

Expression System: E. coli

GPI3 Protein, S. cerevisiae, Recombinant (His & Myc)

Cat.No: TMPH-03453

Species: Saccharomyces cerevisiae

Expression System: E. coli

TIMP-4 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01289

Species: Human

Expression System: HEK293 Cells

MASP2 Protein, Rat, Recombinant (His)

Cat.No: TMPH-03326

Species: Rat

Expression System: Baculovirus Insect Cells

TAG-72 Protein, Canine, Recombinant (His)

Cat.No: TMPK-01308

Species: Canine

Expression System: E. coli

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Cat. No.	Product Name	Target	Signaling Pathways
TMID-0166	Thymine-d4
	Thymine-d4 是 Thymine 的氘代化合物。Thymine 的 CAS 号为 65-71-4。Thymine 是 DNA 的四个碱基之一，在动物癌症模型中，能够作为5-氟尿嘧啶的靶标，其 Km=2.3 μM。

同位素标记化合物

Cat.No: TMID-0166

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