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Cat. No. | Product Name | Target | Signaling Pathways |
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T14064 |
8-Bromo-cGMP sodium
|
Calcium Channel; PKA | Membrane transporter/Ion channel; Metabolism; Tyrosine Kinase/Adaptors |
8-Bromo-cGMP sodium 是一种 PKG 激活剂, 是 cGMP 的膜渗透性类似物。8-Bromo-cGMP sodium 具有缓解疼痛和血管舒张作用,可显着抑制 Ca2+ 宏观电流,抑制高 K+ 刺激的胰岛素释放。 | |||
T11038 |
Dibutyryl-cGMP sodium
Bt2cGMP sodium |
Others | Others |
Dibutyryl-cGMP sodium (Bt2cGMP sodium) is a cell-permeable cGMP analog. Dibutyryl-cGMP sodium preferentially activates cGMP-dependent protein kinase (PKG). Dibutyryl-cGMP sodium inhibits [3H]-arachidonic acid release in human platelets stimulated by gamma | |||
T15670 |
KT5823
|
Apoptosis; PKA | Apoptosis; Tyrosine Kinase/Adaptors |
KT5823 是一种具有选择性和有效性的 cGMP 依赖性蛋白激酶 (PKG) 抑制剂,对 PKA 和 PKG 有抑制作用。KT5823 在甲状腺细胞中通过调节碘化钠交感蛋白的表达和活性来增加甲状腺刺激激素诱导的 (Na+/I- symporter) NIS 表达和碘离子摄取。 KT5823 诱导细胞凋亡。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5065 |
GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD
Monosodium-GMP,cGMP sodium salt,鸟苷-3',5'-环磷酸一钠盐,Cyclic GMP |
PKA | Tyrosine Kinase/Adaptors |
GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD (cGMP sodium salt) 也称为 cGMP,是一种细胞调节剂,被描述为第二信使。它的水平随着各种激素的增加而增加,包括乙酰胆碱、胰岛素和催产素。 cGMP 激活蛋白激酶 G(PKG) 并调节离子通道电导,信号传导影响多种过程,包括平滑肌松弛和增殖、光转导和能量稳态。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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T71141 |
Fenspiride-d5
|
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Fenspiride-d5 is intended for use as an internal standard for the quantification of fenspiride by GC- or LC-MS. Fenspiride is an antagonist of histamine H1 receptors and a non-steroidal anti-inflammatory drug (NSAID). It inhibits histamine-induced contraction of isolated guinea pig trachea but not histamine-induced inotropy of isolated guinea pig heart. It also inhibits phosphodiesterase 4 (PDE4), PDE5, and PDE3 (IC50s = 69, ~158, and 363 µM, respectively, in isolated human bronchi derived from ... |