70
14
2
704
Cat. No. | Product Name | ||
---|---|---|---|
L2130 | 抗癌细胞代谢库 | 1268 compounds | |
1268 种癌细胞代谢相关的生物活性小分子化合物的特有集合,用于肿瘤相关的研究以及抗肿瘤药物的筛选,用于高通量、高内涵筛选; | |||
L2550 | 谷氨酰胺代谢化合物库 | 565 compounds | |
565 种谷氨酰胺代谢相关的分子,可以用于高通量和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP1315 |
c-Myc Peptide Trifluoroacetate
|
Others | Others |
c-Myc Peptide Trifluoroacetate (145646-22-6 free base) 是一种合成肽,对应于人类 c-myc 蛋白的 C 末端氨基酸 (410-419),参与调控生长相关基因的转录。 | |||
TP2311 |
C-MYC PEPTIDE EPITOPE TFA
|
Others | Others |
C-MYC PEPTIDE EPITOPE TFA 是 c-myc 原癌基因的产物,是一种螺旋-环-螺旋亮氨酸拉链磷蛋白,可调节细胞增殖、细胞分化和凋亡中的基因转录。该肽是人类 c-myc 表位。 | |||
T3048 |
10058-F4
c-Myc Inhibitor |
c-Myc; Autophagy | Autophagy; Cell Cycle/Checkpoint |
10058-F4 (c-Myc Inhibitor) 是一种细胞渗透性噻唑烷酮,可特异性抑制 c-Myc-Max 相互作用并防止 c-Myc 靶基因表达的反式激活;诱导细胞周期停滞和凋亡。 | |||
T3686 |
10074-G5
|
c-Myc; Autophagy | Autophagy; Cell Cycle/Checkpoint |
10074-G5是一种c-Myc-Max 二聚化的抑制剂,IC50值为146 μM。 | |||
T9061 |
EN4
EN4 MYC inhibitor |
c-Myc | Cell Cycle/Checkpoint |
EN4 (EN4 MYC inhibitor) 是一种靶向 MYC 的半胱氨酸 171 (C171) 的共价配体。它抑制 MYC 转录活性,下调 MYC 靶标,并具有抗肿瘤作用。它对 c-MYC 的选择性高于 N-MYC 和 L-MYC。 | |||
T15665 |
KJ Pyr 9
|
c-Myc; Autophagy | Autophagy; Cell Cycle/Checkpoint |
KJ Pyr 9 是一种 MYC 的抑制剂,在体外实验中的 Kd 值为 6.5 nM。 | |||
T4252 |
ML327
|
c-Myc; Autophagy | Autophagy; Cell Cycle/Checkpoint |
ML327 是 MYC 的阻断剂,还可抑制 E-钙粘蛋白转录和逆转上皮间质转化。 | |||
T9628 |
10074-A4
|
c-Myc | Cell Cycle/Checkpoint |
10074-A4 是与 c-Myc370-409 结合的 c-Myc 结合化合物,具有抗癌作用,其行为类似于“蛋白质云”周围的“配体云”,具有与非结合配体不同的特征。 | |||
T72040 |
c-Myc inhibitor 7
|
Others | Others |
c-Myc inhibitor 7是c-Myc 抑制剂和多靶点蛋白降解剂,可有效降解多种肿瘤细胞中的c-Myc、CK1α、GSPT1和IKZF1/2/3蛋白,可用于c-Myc 高表达相关疾病的研究,如癌症、心脑血管疾病和病毒感染。 | |||
T4367 |
Mycro 3
Mycro-3 |
c-Myc; Autophagy | Autophagy; Cell Cycle/Checkpoint |
Mycro 3 在全细胞分析中对 c-Myc 具有强效选择性,可用于胰腺癌的研究。 | |||
TP2179 |
c-Myc tag Peptide
|
Others | Others |
c-Myc Peptide is a useful displacement of c-Myc-tagged fusion proteins bound to anti-c-Myc antibodies in immunoassays. The successful inhibition of antibody binding by c-Myc peptide demonstrates binding is specific. c-Myc peptide participates in the regul | |||
T12132 |
MYCi361
NUCC-0196361 |
c-Myc | Cell Cycle/Checkpoint |
MYCi361 (NUCC-0196361) 是一种 MYC 抑制剂,抑制肿瘤生长并增强 anti-PD1 免疫疗法,其与 MYC 结合的 Kd 为 3.2 μM。 | |||
T12134 |
MYCMI-6
NSC354961 |
Apoptosis; c-Myc | Apoptosis; Cell Cycle/Checkpoint |
MYCMI-6 (NSC-354961) 是一种内源性MYC:MAX 蛋白相互作用抑制剂,选择性结合 MYC bHLHZip 域,Kd 值为 1.6 μM。它阻断 MYC 驱动的转录,以 MYC 依赖性的方式抑制肿瘤细胞的生长 ,诱导细胞凋亡。 | |||
T9033 |
BTYNB
MDK6620,BTYNB IMP1 Inhibitor |
Others; c-Myc; NF-κB | Cell Cycle/Checkpoint; NF-κB; Others |
BTYNB (MDK6620) 是IMP1结合 c-Myc mRNA 的有效选择性抑制剂,IC50为 5 μM。它下调 β-TrCP1 mRNA 并减少NF-κB 的激活。它通过损害 IGF2 mRNA 结合蛋白 1 结合来破坏这种增强子功能,可用于癌症研究。 | |||
T60019 |
VPC-70063
Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)- |
Apoptosis; PARP; c-Myc | Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair |
VPC-70063 (Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-) 是 c-Myc-MAX 的抑制剂。 VPC-70063 的 Myc-Max 转录活性抑制率为 106%,IC50 为 8.9 μM,Myc-Max/UBE2C 下游通路抑制率为 94%。 VPC-70063 可用于抗癌研究。 | |||
T10352 |
APTO-253
LOR-253,LT-253 |
Apoptosis; c-Myc; KLF | Apoptosis; Cell Cycle/Checkpoint; MAPK |
APTO-253 (LOR-253) 抑制 c-Myc 表达,稳定 G-四链体 DNA,并诱导急性髓细胞白血病细胞的细胞周期停滞和凋亡。 它通过诱导 KLF4 肿瘤抑制因子介导抗癌活性,具有抗关节炎活性。 | |||
T11284 |
FIDAS-3
|
Others; Wnt/beta-catenin; Methionine Adenosyltransferase (MAT) | Chromatin/Epigenetic; Cytoskeletal Signaling; Others; Stem Cells |
FIDAS-3 是一种强效Wnt 抑制剂,也是一种二苯乙烯衍生物,对甲硫氨酸腺苷转移酶 2A (MAT2A) 的IC50为 4.9 μM。它能够与 S-腺苷甲硫氨酸有效竞争MAT2A 结合,并具有抗癌作用。 | |||
T11285 |
FIDAS-5
|
Others | Others |
FIDAS-5 是甲硫氨酸腺苷转移酶 2A 抑制剂(IC50:2.1 μM),具有口服活性。它能够与 S-腺苷甲硫氨酸有效竞争 MAT2A 结合,并具有抗癌作用。 | |||
T20533 |
NNK
Nicotine-derived nitrosamine ketone |
Lipoxygenase | Metabolism |
NNK (Nicotine-derived nitrosamine ketone) 是尼古丁亚硝化衍生物。它可以激活 ERK1/2和 PKCα,并在 Ser70 激活 Bcl2磷酸化,以及在 Thr58和 Ser62激活 c-Myc。它可用于构建肺癌小鼠模型,以及诱导人肺癌细胞的增殖和存活。 | |||
T10760 |
Ceramides Mixture
神经酰胺混合物,神经酰胺 |
Telomerase | DNA Damage/DNA Repair |
Ceramides Mixture 是表皮渗透屏障的主要脂质成分,参与生长抑制,细胞周期停滞和端粒酶活性的调节。它是一种内源性神经酰胺,由含羟基和非羟基脂肪酸的神经酰胺组成。 | |||
T9093 |
NY2267
Acetic acid, 2-[[6-[2-(cyclohexylamino)-1-[[(4-methoxyphenyl)methyl](2-pyridinylcarbonyl)amino]-2-oxoethyl]-2-naphthalenyl]oxy]-, 1,1-dimethylethyl ester |
c-Myc | Cell Cycle/Checkpoint |
NY2267 (Acetic acid, 2-[[6-[2-(cyclohexylamino)-1-[[(4-methoxyphenyl)methyl](2-pyridinylcarbonyl)amino]-2-oxoethyl]-2-naphthalenyl]oxy]-, 1,1-dimethylethyl ester) 是一种 Myc-Max 相互作用干扰物,抑制 Myc 和 Jun 诱导的转录激活,其 IC50值为 36.5 μM。 | |||
T10765 |
Eragidomide
CC-90009,Cereblon modulator 1 |
Apoptosis; Ligand for E3 Ligase; Molecular Glues | Apoptosis; PROTAC |
Cereblon modulator 1 是一种 GSPT1 选择性cereblon (CRBN)E3 连接酶调节剂,以分子胶的方式作用。它通过 CRL4CRBN选择性靶向 GSPT1 进行泛素化和蛋白酶体降解。 | |||
T6010 |
Idarubicin hydrochloride
盐酸伊达比星,Idamycin,4-demethoxydaunorubicin (NSC256439, 4-DMDR) HCl,4-Demethoxydaunorubicin hydrochloride,Idarubicin HCl,伊达比星盐酸盐,Zavedos |
Topoisomerase; Antibacterial; Autophagy; Antifungal | Autophagy; DNA Damage/DNA Repair; Microbiology/Virology |
Idarubicin hydrochloride (Zavedos) 是一种蒽环类抗白血病药物,能抑制细菌和酵母菌生长,还抑制拓扑异构酶 II,干扰 DNA 复制和 RNA 转录。 | |||
T6203 |
Saxagliptin
BMS-477118,沙克列汀,Onglyza,沙格列汀 |
Proteasome; DPP-4 | Proteases/Proteasome; Ubiquitination |
Saxagliptin (BMS-477118) 是一种选择性,可逆性,竞争性和口服活性的二肽基肽酶 4 (DPP-4) (Ki= 0.6-1.3 nM) 抑制剂。Saxagliptin 能够用于 2 型糖尿病的研究。 | |||
T79439 |
c-Myc inhibitor 12
|
c-Myc | Cell Cycle/Checkpoint |
c-Myc inhibitor12 (compound 67h),作为c-Myc抑制剂,具有pEC50值为6.4。 | |||
T79438 |
c-Myc inhibitor 11
|
c-Myc | Cell Cycle/Checkpoint |
c-Myc inhibitor11(Compound 67e),一种c-MYC抑制剂(pEC50: 6.4),在大鼠药代动力学评估中表现出高清除率、中等体积分布和短半衰期,适用于癌症研究领域。 | |||
T72619 |
c-Myc inhibitor 8
|
Others | Others |
c-Myc inhibitor8 是一种 c-Myc 抑制剂。c-Myc inhibitor8 有效抑制多种癌细胞的细胞活力。c-Myc inhibitor8 在小鼠模型中抑制人前列腺癌和肺癌肿瘤的生长。c-Myc inhibitor8 可用于癌症研究。 | |||
T63359 |
c-Myc inhibitor 4
|
Others | Others |
c-Myc inhibitor 4 是有效的、口服具有活性的 c-Myc-reducing 化合物。C-Myc 是一种重要的原癌基因,与多种肿瘤的发生发展密切相关。 | |||
T0178 |
Saxagliptin hydrate
沙格列汀单水化合物,Onglyza hydrate,BMS-477118 hydrate |
Proteasome; DPP-4 | Proteases/Proteasome; Ubiquitination |
Saxagliptin hydrate (Onglyza hydrate) 是一种选择性,竞争性,可逆性和口服活性的二肽基肽酶 4 (DPP-4) (Ki= 0.6-1.3 nM) 抑制剂。Saxagliptin hydrate 能够用于 2 型糖尿病的研究。 | |||
T74460 |
c-Myc inhibitor 5
|
Others | Others |
c-Myc inhibitor5 (DA3) 是一种荧光长链桥双嘌呤,可选择性靶向 c-MYCG-四链体(KD16 μM)。c-Myc inhibitor5 显示对 c-MYC 表达的抑制作用,而不是其他 G4 驱动的癌基因。 | |||
T75239 |
c-Myc inhibitor 10
|
Others | Others |
c-Myc inhibitor10 (compound 17) 是 c-myc 的抑制剂,表现出一定的的细胞效力,与甲基化的 morpholine 氮的通透性增加一致。 | |||
T72620 |
c-Myc inhibitor 9
|
Others | Others |
c-Myc inhibitor9 是一种c-Myc 抑制剂,logEC50值 ≥6。c-Myc inhibitor9 抑制异种移植裸鼠模型中肿瘤的生长。c-Myc inhibitor9 可用于癌症研究。 | |||
T74793 |
USP28-IN-3
|
DUB | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination |
USP28-IN-3是一种高选择性 USP28 抑制剂,对USP28的IC50 值为 0.1 μM。USP28-IN-3 具有抗癌活性,抑制 USP2、USP7、USP8、USP9x、UCHL3和UCHL5。USP28-IN-3 对人结直肠癌和肺鳞癌细胞具有细胞毒性,通过泛素-蛋白酶体系统对c-Myc的细胞水平进行剂量依赖性下调。 | |||
T28543 |
RK-9123016
RK9123016,RK 9123016 |
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
RK-9123016是一种SIRT2抑制剂。RK-9123016增加真核翻译起始因子5A(eIF5A)(SIRT2的生理底物)的乙酰化水平,降低人乳腺癌细胞的细胞活力,同时降低c-Myc 表达。 | |||
T74794 |
USP28-IN-4
|
DUB | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination |
USP28-IN-4 是一种高效的 USP28 抑制剂,对 USP28 的 IC50 值为 0.04 μM。USP28-IN-4 具有抗癌活性,抑制 USP2、USP7、USP8、USP9x、UCHL3和UCHL5。USP28-IN-4 对人结直肠癌和肺鳞癌细胞具有细胞毒性,通过泛素-蛋白酶体系统对c-Myc的细胞水平进行剂量依赖性下调。 | |||
T15137 |
DK419
|
Wnt/beta-catenin; AMPK | Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Stem Cells |
DK419 是一种具有口服活性的 Wnt/β-catenin 信号通路抑制剂,IC50 为 0.19 μM。 DK419 降低 Axin2、β-catenin、c-Myc、Cyclin D1 和 Survivin 的蛋白质水平。它还诱导 pAMPK 的产生。 | |||
T60485 |
DIF-3
|
Others | Others |
DIF-3 is a chemical compound that acts by activating GSK-3β to facilitate the degradation of cyclin D1 and c-Myc, resulting in reduced expression levels of these proteins. In addition, DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in DLD-1 cells. This compound exerts a potent antiproliferative effect on the HeLa human cervical cancer cell line by inducing cyclin D1 degradation and inhibiting cyclin D1 mRNA expression [1]. | |||
T16932 |
SRT 2183
|
Apoptosis; Sirtuin | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair |
SRT 2183 是一种选择性Sirtuin-1激活剂,其EC1.5值为 0.36 μM。它诱导生长停滞和凋亡,同时伴随 STAT3 和 NF-κB 去乙酰化,并降低 c-Myc 蛋白水平。 | |||
T3708 |
BP-1-102
|
STAT | JAK/STAT signaling; Stem Cells |
BP-1-102 是可口服的转录因子Stat3小分子抑制剂,IC50值为 6.8 μM。 | |||
T10717 |
Inobrodib
CBP-IN-1 |
Epigenetic Reader Domain | Chromatin/Epigenetic |
Inobrodib (CBP-IN-1) 是一种口服活性的强选择性p300/CBP 抑制剂,与 p300 和 CBP 结合,Kd 值为 1.3 和 1.7 nM。它抑制前列腺癌细胞系的细胞增殖并降低雄激素受体和 C-MYC 调节的基因表达。 | |||
T11783 | KSI-3716 | c-Myc | Cell Cycle/Checkpoint |
KSI-3716 is an inhibitor of c-Myc. | |||
T11698 |
IZCZ-3
|
Others | Others |
IZCZ-3,antitumor activity. is a potent c-MYC transcription inhibitor. | |||
T77939 |
WBC100
14-D-Valine-TPL |
c-Myc | Cell Cycle/Checkpoint |
WBC100(14-D-Valine-TPL),一款高效、选择性和具口服活性的c-Myc小分子降解剂,通过针对泛素E3连结酶CHIP介导的26S蛋白酶体途径实现其作用。主要应用于c-Myc过表达肿瘤的研究领域。 | |||
T63884 |
IZTZ-1
|
Others | Others |
IZTZ-1 是一种 c-MYC G4配体,是咪唑-苯并噻唑缀合物。IZTZ-1 能够稳定 c-MYC G4,并下调 c-MYC 的表达。IZTZ-1 能够阻滞细胞周期,并诱导细胞凋亡 (apoptosis),能够抑制 B16 细胞的增殖。IZTZ-1 表现出抗肿瘤作用,能够用于研究黑色素瘤。 | |||
T24548 |
NSC10010 hydrochloride
NSC#10010,NSC 10010,NSC# 10010,NSC#-10010,NSC-10010 |
Others | Others |
NSC10010 hydrochloride is an effective growth inhibitor for gammaherpesvirus-associated B-lymphomas. It acts through activation of both the NF-κB and c-Myc-mediated signaling pathways. | |||
T74961 |
Anticancer agent 84
|
Others | Others |
Anticancer agent 84 是抗癌剂。Anticancer agent 84 通过稳定 G-四链体 (G4) 结构来抑制c-MYC 的转录。Anticancer agent 84 可用于癌症研究。 | |||
T69464 |
Mycro2
|
Others | Others |
Mycro2 is an inhibitor of the protein-protein interactions between the bHLHZip proteins c-Myc and Max. | |||
T37036 |
hnRNPK-IN-1
|
Others | Others |
hnRNPK-IN-1 is a specific ligand that binds to the heterogeneous nuclear ribonucleoprotein K (hnRNPK) with high affinity, evidenced by Kd values of 4.6 μM and 2.6 μM determined using surface plasmon resonance (SPR) and microscale thermophoresis (MST), respectively. This binding event leads to the disruption of hnRNPK's interaction with the c-myc promoter, resulting in the inhibition of c-myc transcription. Additionally, hnRNPK-IN-1 induces apoptosis in Hela cells and exhibits potent anti-tumor a... | |||
T23872 |
Cellocidin
NSC65381,NSC# 65381,NSC-65381,NSC#65381,NSC 65381 |
Others | Others |
Cellocidin is a potent gammaherpesvirus-associated B-lymphomas growth inhibitor. It acts through the activation of both the NF-κB and c-Myc-mediated signaling pathways. | |||
T79872 |
m-Se3
|
c-Myc | Cell Cycle/Checkpoint |
m-Se3 为一选择性c-MYC转录抑制剂,有效抑制肿瘤生长且表现出抗癌活性。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1892 |
Lusianthridin
|
Others; c-Myc | Cell Cycle/Checkpoint; Others |
Lusianthridin 是来自石斛 Dendrobium venustum 的天然产物。 Lusianthridin 在无毒浓度下表现出抗迁移特性。 Lusianthridin 通过抑制 Src-STAT3 信号传导增强 c-Myc 降解。 | |||
T21065 |
Artemisitene
|
Others | Others |
Artemisitene 是青蒿素的氧化形式,是一种抗疟药。青蒿素前体是青蒿素生物合成的重要基础物质,包括青蒿素 B、青蒿素、青蒿酸等。 | |||
T3673 |
Mollugin
大叶茜草素,Rubimaillin |
HER; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Mollugin (Rubimaillin) 是Rubia cordifolia L.中主要的生物活性成分。它能通过 p38-Smad 信号通路增强 BMP-2 的成骨作用。它通过抑制 TNF-α 诱导的 NF-κB 激活起抗癌疗效。 | |||
T4S1173 |
Agrimol B
仙鹤草酚B,仙鹤草酚 B |
Sirtuin; PPAR | Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism |
Agrimol B 是从仙鹤草中分离得到的一种多酚衍生物,可抑制脂肪形成,降低PPARγ的表达,诱导SIRT1易位和表达。 | |||
T2764 |
(S)-10-Hydroxycamptothecin
10-羟喜树碱,10-羟基喜树碱,10-Hydroxycamptothecin,10-HCPT |
Apoptosis; Topoisomerase | Apoptosis; DNA Damage/DNA Repair |
(S)-10-Hydroxycamptothecin (10-HCPT) 是一种从喜树中分离的 DNA 拓扑异构酶 I 抑制剂。它显著诱导细胞凋亡,可研究肝癌、胃癌、结肠癌和白血病。 | |||
TN1543 |
Cynaropicrin
|
HCV Protease; NF-κB; Microtubule Associated | Cytoskeletal Signaling; Microbiology/Virology; NF-κB; Proteases/Proteasome |
Cynaropicrin 是一种存在于朝鲜蓟 (Cynara scolymus) 中倍半萜内酯,具有抗丙型肝炎活性和抗锥虫活性活性,抑制NF-κB活化。 Cynaropicrin 破坏微管蛋白和 c-Myc 相关信号传导,并诱导多发性骨髓瘤中的 parthanatos 型细胞死亡。 | |||
T5S1103 |
Isoliensinine
异莲心碱,Isoliensinin |
Apoptosis; Antioxidant | Apoptosis; oxidation-reduction |
Isoliensinine (Isoliensinin) 是从水芙蓉种子胚中提取的一种双苄基异喹啉生物碱,能诱导三阴性乳腺癌细胞凋亡,具有抗氧化、抗炎、抗癌活性。 | |||
T2336 |
Vitamin K2
Menatetrenone,四烯甲萘醌 |
Endogenous Metabolite | Metabolism |
Vitamin K2 (Menatetrenone) 是内源性代谢产物的一种。 | |||
TN6508 |
Trachelogenin
(-)-Trachelogenin |
Virus Protease; c-Myc; HCV Protease; Wnt/beta-catenin | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Microbiology/Virology; Proteases/Proteasome; Stem Cells |
Trachelogenin ((-)-Trachelogenin) 分离自Combretum fruticosum,是一种 HCV 进入抑制剂 具有抗增殖作用,其机制与影响β-Catenin 信号通路中的 β-Catenin、c-Myc 和 GSK3 等关键蛋白的磷酸化有关,且呈浓度依赖性。Trachelogenin具有抗病毒、抗炎和镇痛活性,在 HCVcc 和 HCVpp 模型中的 IC50 分别为 0.325 和 0.259 μg/mL。 | |||
T27304 |
Farnesiferol C
Farnesiferol-C |
||
Farnesiferol C induces apoptosis via regulation of L11 and c-Myc. | |||
TMA1743 |
Ergosterol peroxide
|
ERK; VEGFR; p38 MAPK; Wnt/beta-catenin; Akt; JAK; CDK; JNK; STAT; Antifection | Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; MAPK; Microbiology/Virology; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Foxo3a activity by inhibiting pAKT and c-Myc and activating pro-apoptotic protein Puma and Bax to | |||
T75621 |
Secalonic acid D
|
Others | Others |
Secalonic acid D 是一种抗肿瘤细胞的有毒化合物。Secalonic acid D 可以从Aspergillus aculeatus 的代谢产物中分离得到。Secalonic acid D 激活GSK3-β,并降解β-catenin。因此,Secalonic acid D 下调c-Myc 表达,使细胞周期停滞在 G1 期,诱导细胞凋亡 (apoptosis)。 | |||
TN4582 |
Moracin T
|
c-Myc; COX | Cell Cycle/Checkpoint; Immunology/Inflammation; Neuroscience |
Moracin treatment can inhibit the double 12-O-tetradecanoylphorbol 13-acetate (TPA) treatment-induced morphological changes reflecting inflammatory response, including leucocyte infiltration, hyperplasia and cell proliferation; moracin treatment furthermo | |||
T36954 |
Nemorosone
|
Others | Others |
Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 μM).2 It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nem... |
Cat. No. | Product Name | Species | Expression System |
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TMPH-01720 |
c-Myc Protein, Human, Recombinant (His)
Myc proto-oncogene protein,Transc... |
Human | E. coli |
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release. c-Myc Protein, Human, Recombinant (His) is... | |||
TMPH-02791 |
c-Myc Protein, Mouse, Recombinant (GST)
bHLHe39,MYC,Transcription factor ... |
Mouse | E. coli |
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release. c-Myc Protein, Mouse, Recombinant (GST) is... | |||
TMPH-01721 |
c-Myc Protein, Human, Recombinant (Avi & His & MBP), Biotinylated
BHLHE39,Class E basic helix-loop-helix pro... |
Human | E. coli |
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release. c-Myc Protein, Human, Recombinant (Avi & H... | |||
TMPH-01801 |
NME2 Protein, Human, Recombinant (His & Myc)
NME2,nm23-H2,Histidine protein kinase NDKB,Nucleosi... |
Human | E. coli |
NME2 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 24.2 kDa and the accession number is P22392. | |||
TMPH-02665 |
Aldolase C Protein, Mouse, Recombinant (His & Myc)
Aldolase 3,Brain-type aldolase,Aldo3,Scrg2,Sc |
Mouse | E. coli |
Aldolase C Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli with N-terminal 10xHis tag and C-terminal Myc tag. The predicted molecular weight is 46.7 kDa. Accession number: P05063 | |||
TMPH-02628 |
Cathepsin C Protein, Mouse, Recombinant (His & Myc)
Dipeptidyl transferase,Dipeptidyl peptidase I,Cathe... |
Mouse | E. coli |
Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function. | |||
TMPH-01375 |
Gasdermin-C Protein, Human, Recombinant (His & Myc)
GSDMC,Melanoma-derived leucine zipper-... |
Human | Baculovirus Insect Cells |
Gasdermin-C Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 61.7 kDa and the accession number is Q9BYG8. | |||
TMPH-00014 |
Abrin-c Protein, Abrus precatorius, Recombinant (His & Myc)
|
Abrus precatorius | E. coli |
The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. Abrin-a is more toxic than ricin.; The B chain is a galactose-specific lectin that facilitates the binding of abrin to the cell membrane that precedes endocytosis. Abrin-c Protein, Abrus precatorius, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight ... | |||
TMPH-00902 |
Human adenovirus C serotype 5 Protease (His & Myc)
Protease,Adenain,Endoprotease,Adenovirus proteinase,L3,Adeno... |
HAdV-5 | E. coli |
Human adenovirus C serotype 5 Protease (His & Myc) is expressed in E. coli. | |||
TMPH-02688 |
Granzyme C/GZMC Protein, Mouse, Recombinant (His & Myc)
Cytotoxic cell protease 2,B10,Gzm... |
Mouse | E. coli |
This enzyme is probably necessary for target cell lysis in cell-mediated immune responses. Granzyme C/GZMC Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 32.6 kDa and the accession number is P08882. | |||
TMPH-02773 |
Lysozyme C-2 Protein, Mouse, Recombinant (His & Myc)
Lysozyme C-2,1,4-beta-N-acetylmuramidase <... |
Mouse | E. coli |
Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Lyz2 is active against a range of Gram-positive and Gram-negative bacteria. More effective than Lyz1 in killing Gram-negative bacteria. Lyz1 and Lyz2 are equally effective in killing Gram-positive bacteria. Lysozyme C-2 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-M... | |||
TMPH-03618 |
Clotting factor C Protein, Tachypleus tridentatus, Recombinant (His & Myc)
FC,Limulus factor C,Clot... |
Tachypleus tridentatus | E. coli |
This enzyme is closely associated with an endotoxin-sensitive hemolymph coagulation system which may play important roles in both hemostasis and host defense mechanisms. Its active form catalyzes the activation of clotting factor B. Clotting factor C Protein, Tachypleus tridentatus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 33.8 kDa and the accession number is P28175. | |||
TMPH-00901 |
Human adenovirus C serotype 5 Fiber protein (His & Myc)
Fiber protein,Protein IV |
HAdV-5 | E. coli |
Human adenovirus C serotype 5 Fiber protein (His & Myc) is expressed in E. coli. | |||
TMPH-03600 |
Glucosyltransferase-SI Protein, S. mutans serotype c, Recombinant (His & Myc)
gtfC,Glucosyltransferase-SI,Dextransuc... |
Streptococcus mutans | E. coli |
Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris. Glucosyltransferase-SI Protein, S. mutans serotype c, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 26.7 kDa and the accession number is P13470. | |||
TMPH-00413 |
HA-33 Protein, Clostridium botulinum C phage, Recombinant (His & Myc & SUMO)
HA 33 kDa subunit,ANTP33,HA1,HA-33,Main hemagglutinin c<... |
Clostridium botulinum | E. coli |
HA-33 Protein, Clostridium botulinum C phage, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 53.6 kDa and the accession number is P0DPR0. | |||
TMPH-00899 |
Human adenovirus C serotype 5 E1B 55 kDa protein (His & Myc)
E1B protein, large T-antigen,E1B-495R,E1B 55 kDa protein |
HAdV-5 | E. coli |
Human adenovirus C serotype 5 E1B 55 kDa protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 62.4 kDa and the accession number is P03243. | |||
TMPH-01519 |
HIV-1 (group M, subtype C, isolate 92BR025) Protein Vpr (His & Myc)
Viral protein R,vpr,Protein Vpr,R ORF protein |
HIV-1 | E. coli |
HIV-1 (group M, subtype C, isolate 92BR025) Protein Vpr (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 18.9 kDa and the accession number is O12160. | |||
TMPH-01439 |
Human herpesvirus 1 (HHV-1) (strain 17) Envelope glycoprotein C (His & Myc)
gC,Envelope glycoprotein C |
HHV-1 | E. coli |
Human herpesvirus 1 (HHV-1) (strain 17) Envelope glycoprotein C (His & Myc) is expressed in E. coli. | |||
TMPH-00897 |
Human adenovirus C serotype 2 Early E3 18.5 kDa glycoprotein (His & Myc)
GP19K,Early E3 18.5 kDa glycoprotein,E3gp 19 kDa,E3... |
HAdV-2 | E. coli |
Binds and retains class I heavy chains in the endoplasmic reticulum during the early period of virus infection, thereby impairing their transport to the cell surface. Also delays the expression of class I alleles that it cannot affect by direct retention. Binds transporters associated with antigen processing (TAP) and acts as a tapasin inhibitor, preventing class I/TAP association. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes. Human adenovirus C ser... | |||
TMPH-00857 |
ABAT Protein, Human, Recombinant (His & Myc & SUMO)
L-AIBAT,GABA aminotransferase,GABA transaminase,GABA-T,(S)-3... |
Human | E. coli |
Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine. ABAT Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 73.3 kDa and the accession number is P80404. | |||
TMPH-01034 |
CTAG1A Protein, Human, Recombinant (hFc & Myc)
CTAG1,ESO1,LAGE-2,CT6.1,LAGE2,L antigen fa... |
Human | HEK293 Cells |
CTAG1A Protein, Human, Recombinant (hFc & Myc) is expressed in HEK293 mammalian cells with C-hFc-Myc tag. The predicted molecular weight is 48.1 kDa and the accession number is P78358. | |||
TMPH-00845 |
HSD17B13 Protein, Human, Recombinant (His & Myc)
Hepatic retinol/retinal dehydrogenase,Short c |
Human | P. pastoris (Yeast) |
HSD17B13 Protein, Human, Recombinant (His & Myc) is expressed in yeast with N-6xHis and C-Myc tag. The predicted molecular weight is 34.8 kDa and the accession number is Q7Z5P4. | |||
TMPH-03747 |
CCDC112 Protein, Human, Recombinant (His & Myc)
Mutated in bladder cancer protein 1,C<... |
Human | E. coli |
CCDC112 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 61.0 kDa and the accession number is Q8NEF3. | |||
TMPH-02182 |
CD3G Protein, Human, Recombinant (His & Myc)
T-cell receptor T3 gamma chain, |
Human | E. coli |
CD3G Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 18.2 kDa and the accession number is P09693. | |||
TMPH-02421 |
APOE Protein, Cynomolgus, Recombinant (His & Myc)
Apolipoprotein E,Apo-E,APOE |
Cynomolgus | E. coli |
APOE Protein, Cynomolgus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 39.0 kDa and the accession number is P10517. | |||
TMPH-00978 |
DDX3X Protein, Human, Recombinant (His & Myc)
DEAD box, X isoform,DEAD box protein 3, X-chromosom... |
Human | Baculovirus Insect Cells |
DDX3X Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 77 kDa and the accession number is O00571. | |||
TMPH-01255 |
DNM1L Protein, Human, Recombinant (His & Myc)
Dynamin-like protein IV,Dynamin-related protein 1,DLP1,Dympl... |
Human | E. coli |
DNM1L Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 84.4 kDa and the accession number is O00429. | |||
TMPH-02950 |
HADHB Protein, Mouse, Recombinant (His & Myc)
TP-beta,Trifunctional enzyme subunit beta, mito... |
Mouse | E. coli |
HADHB Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 54.6 kDa and the accession number is Q99JY0. | |||
TMPH-02786 |
MAPK14 Protein, Mouse, Recombinant (His & Myc)
Mapk14,Mitogen-activated protein kinase p38 alpha,<... |
Mouse | E. coli |
MAPK14 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 48.6 kDa and the accession number is P47811. | |||
TMPH-02322 |
SLC30A10 Protein, Human, Recombinant (His & Myc)
SLC30A10,Zinc transporter 10,Cal<... |
Human | E. coli |
SLC30A10 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 27.9 kDa and the accession number is Q6XR72. | |||
TMPH-01884 |
PCBP2 Protein, Human, Recombinant (His & Myc)
Heterogeneous nuclear ribonucleoprotein E2... |
Human | E. coli |
PCBP2 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 46.0 kDa and the accession number is Q15366. | |||
TMPH-01657 |
MAGEA3 Protein, Human, Recombinant (His & Myc)
Melanoma-associated antigen 3,MAGE-3 antigen,C<... |
Human | E. coli |
MAGEA3 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 39.8 kDa and the accession number is P43357. | |||
TMPH-02942 |
TEAD4 Protein, Mouse, Recombinant (His & Myc)
TEF-1-related factor FR-19,TEF-1-related fac |
Mouse | E. coli |
TEAD4 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 33.0 kDa and the accession number is Q62296. | |||
TMPH-02224 |
TEAD4 Protein, Human, Recombinant (His & Myc)
Transcription factor 13-like 1,TEA domain ... |
Human | Baculovirus Insect Cells |
TEAD4 Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 44.5 kDa and the accession number is Q15561. | |||
TMPH-02015 |
Recoverin Protein, Human, Recombinant (His & Myc)
RCVRN,Recoverin,Cancer-a... |
Human | HEK293 Cells |
Recoverin Protein, Human, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 27.0 kDa and the accession number is P35243. | |||
TMPH-02793 |
Myocilin Protein, Mouse, Recombinant (His & Myc)
Trabecular meshwork-induced gluco... |
Mouse | Baculovirus Insect Cells |
Myocilin Protein, Mouse, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 35.2 kDa and the accession number is O70624. | |||
TMPH-00856 |
RPSA Protein, Human, Recombinant (His & Myc)
67 kDa laminin receptor,RPSA,Laminin-binding protei... |
Human | E. coli |
RPSA Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 37.7 kDa and the accession number is P08865. | |||
TMPH-02916 |
SULT1A1 Protein, Mouse, Recombinant (His & Myc)
Sulfotransferase 1A1,ST1A4,Aryl sulfotransferase,Sulfokinase... |
Mouse | E. coli |
SULT1A1 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 39.0 kDa and the accession number is P52840. | |||
TMPH-03366 |
RUNX1 Protein, Rat, Recombinant (His & Myc)
Runt-related transcription factor 1,C<... |
Rat | Baculovirus Insect Cells |
RUNX1 Protein, Rat, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 52.4 kDa and the accession number is Q63046. | |||
TMPH-01701 |
SMAD6 Protein, Human, Recombinant (His & Myc)
SMAD family member 6,Mothers against decapentaplegi... |
Human | Baculovirus Insect Cells |
SMAD6 Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 57.4 kDa and the accession number is O43541. | |||
TMPH-01786 |
NCBP1 Protein, Human, Recombinant (His & Myc)
Nuclear cap-binding protein subunit 1,N |
Human | Baculovirus Insect Cells |
NCBP1 Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 95.7 kDa and the accession number is Q09161. | |||
TMPH-02429 |
Fukutin Protein, Cynomolgus, Recombinant (His & Myc)
FKTN,Fukutin,Fukuyama-type congenital musc... |
Cynomolgus | E. coli |
Fukutin Protein, Cynomolgus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 58.0 kDa and the accession number is Q60HG0. | |||
TMPH-02302 |
VPS4A Protein, Human, Recombinant (His & Myc)
VPS4-1,Protein SKD2,VPS4A,Vacuolar protein sorting-... |
Human | E. coli |
VPS4A Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 53.9 kDa and the accession number is Q9UN37. | |||
TMPH-00055 |
Alpha-toxin Amm8 Protein, Androctonus mauritanicus, Recombinant (His & Myc)
AmmVIII,Neurotoxin 8,Alpha-anatoxin Amm VIII,Amm VIII |
Androctonus mauritanicus | Baculovirus Insect Cells |
Alpha-toxin Amm8 Protein, Androctonus mauritanicus, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 11.3 kDa and the accession number is Q7YXD3. | |||
TMPH-01901 |
DDX53 Protein, Human, Recombinant (His & Myc)
DEAD box protein CAGE,DEAD box protein 53,C |
Human | E. coli |
N/A. DDX53 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 76.2 kDa and the accession number is Q86TM3. | |||
TMPH-00226 |
ATPase subunit g Protein, Bovine, Recombinant (His & Myc)
ATP synthase subunit g, mitochondrial,ATP5MG,ATP sy... |
Bovine | E. coli |
ATPase subunit g Protein, Bovine, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 18.7 kDa and the accession number is Q28852. | |||
TMPH-02589 |
COL26A1 Protein, Mouse, Recombinant (His & Myc)
Col26a,Col26a1,Emu2,Emid2,Emilin and multi... |
Mouse | Baculovirus Insect Cells |
N/A. COL26A1 Protein, Mouse, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 47.7 kDa and the accession number is Q91VF6. | |||
TMPH-03678 |
Vaccinia virus (strain Copenhagen) OPG125 Protein (His & Myc)
62 kDa protein,Rifampicin resistance prote... |
VACV | E. coli |
Vaccinia virus (strain Copenhagen) OPG125 Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 33.2 kDa and the accession number is P68441. | |||
TMPH-02657 |
Fibrin Protein, Mouse, Recombinant (His & Myc)
Fibin,Fin bud initiation factor homolog |
Mouse | Baculovirus Insect Cells |
N/A. Fibrin Protein, Mouse, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 26.5 kDa and the accession number is Q9CQS3. | |||
TMPH-01342 |
Filamin-A Protein, Human, Recombinant (His & Myc)
FLNA,Filamin-1,Actin-binding protein 280,Alpha-fila... |
Human | E. coli |
Filamin-A Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 38.0 kDa and the accession number is P21333. | |||
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