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Cat. No. | Product Name | ||
---|---|---|---|
L4700 | 免疫/炎症分子化合物库 | 4720 compounds | |
4720 种具有抗炎症活性的化合物的特有集合,可用于高通量筛选和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13920L |
Terlipressin Acetate
Terlipressin diacetate anhydrous,Terlipressin acetate anhydrous,醋酸特利加压素 |
Vasopressin Receptor | GPCR/G Protein |
Terlipressin Acetate 是一种高度选择性的加压素 V1 受体激动剂,对氧和葡萄糖剥夺/再氧合 (OGD/R) 诱导的肠上皮细胞损伤 (IEC-6) 具有抗炎和抗氧化作用,可用于肝肾综合征和耐去甲肾上腺素的败血性休克的研究。 | |||
T6991 |
Nitroprusside disodium dihydrate
硝普钠二水合物,硝普钠,Sodium Nitroferricyanide(III) Dihydrate,Sodium Nitroprusside Dihydrate |
Guanylate cyclase; Autophagy | Autophagy; GPCR/G Protein |
Nitroprusside disodium dihydrate (Sodium Nitroprusside Dihydrate) 是一种血管扩张剂,通过在血液中自发释放 NO 发挥作用。它可在谷胱甘肽耗竭的成骨细胞中诱导自噬,用于急性高血压和心力衰竭的研究。 | |||
T11918 |
Lysipressin
Lysine vasopressin,[Lys8]-Vasopressin,赖氨加压素 |
Others | Others |
Lysipressin ([Lys8]-Vasopressin) 是一种抗利尿激素,从猪身上发现,能够诱发兔膀胱平滑肌的收缩,激活腺苷酸环化酶。 | |||
T7601L |
Carbetocin acetate
醋酸卡贝缩宫素,Carbetocin acetate(37025-55-1 free base),卡贝缩宫素醋酸盐 |
Oxytocin Receptor | Endocrinology/Hormones; GPCR/G Protein |
Carbetocin acetate 是催产素类似物,是催产素受体激动剂,Ki 是 7.1 nM。它对催产素受体的嵌合 N 末端具有高亲和力,Ki 为 1.17 μM。它能透过血脑屏障,可以通过激活 CNS 中的催产素受体而具有类抗抑郁活性,具有用于产后出血的研究潜力。 | |||
T1514 |
Norethindrone
Norethisterone,炔诺酮 |
Estrogen/progestogen Receptor; Progesterone Receptor | Endocrinology/Hormones; Others |
Norethindrone (Norethisterone) 是孕激素,能够用于子宫内膜异位症、由激素水平异常引起的子宫出血和继发性闭经的研究。 | |||
T11824LL |
Lanraplenib
GS-9876 |
Syk | Angiogenesis; Tyrosine Kinase/Adaptors |
Lanraplenib (GS-9876) 是高效的、选择性的、口服具有活力的 SYK 抑制剂 (IC50=9.5 nM) ,能够用于炎症性疾病的研究。它通过糖蛋白 VI (GPVI) 受体抑制血小板中的 SYK 活性,而不会延长猴子或人类的出血时间 (BT)。 | |||
T3536 |
AZD1283
|
P2Y Receptor | GPCR/G Protein; Neuroscience |
AZD1283是P2Y12受体拮抗剂,EC50为3.0 ug/kg/min,结合的IC50为11 nM。它剂量依赖性地诱导血流量增加和抑制 ADP 诱导的血小板聚集,抗血栓形成的 ED50 值分别为 3.0 和 10 μg/kg/min。 | |||
T70349 |
DJT06001
|
Others | Others |
DJT06001 is a selective Factor Xa inhibitor, reducing thrombus formation with low risk of bleeding. | |||
T20855 |
Gemeprost
SC-37681,SC 37681,Carprost,Gemeprostum,Cervagem,Preglandin |
Others | Others |
Gemeprost, an analog of prostaglandin E1, is used for the treatment of obstetric bleeding. It is used to terminate pregnancy up to 24 weeks gestation together with mifepristone. | |||
T28237 |
Onapristone
IVV-1001,ZK 98299,IVV 1001,ZK98299,ZK-98299,IVV1001 |
Others | Others |
Onapristone, a progesterone receptor antagonist, is used potentially for the treatment of breast cancer, advanced prostate cancer, and inducer of vaginal bleeding. | |||
T28491 |
R-1663
R1663 |
Others | Others |
R-1663 is a factor Xa inhibitor. R-1663 prolonged clotting times, inhibited thrombin generation (peak height and endogenous thrombin potential [ETP]) and anti-factor Xa activity in a concentration-dependent manner without increasing bleeding time. Pharmac | |||
T0171 |
Norethynodrel
Lynestrol,异炔诺酮 |
Estrogen/progestogen Receptor | Endocrinology/Hormones |
Norethynodrel (Lynestrol) 是一种合成的孕激素,其作用和用途类似于孕酮。它已被用于治疗功能性子宫出血和子宫内膜异位症。它作为避孕药,通常与 MESTRANOL 联合使用。 | |||
T16377 |
Odiparcil
SB-424323 |
Thrombin | Proteases/Proteasome |
Odiparcil is an orally active beta-d-thioxyloside analog. Odiparcil is an indirect thrombin inhibitor that exerts its anticoagulant effect through activation of antithrombin II (heparin cofactor II). It also has an antithrombotic activity associated with a reduced risk of adverse bleeding events. | |||
T68681 |
Casuarinin
|
Others | Others |
Casuarinin is an ellagitannin. It is found in the pericarp of pomegranates. It is also found in Casuarina and Stachyurus species and in Alnus sieboldiana. It is an isomer of casuarictin. It is a highly active carbonic anhydrase inhibitor. It is a compound that causes the contraction of body tissues, typically used to reduce bleeding from minor abrasions. | |||
T11824L |
Lanraplenib monosuccinate
GS-9876 monosuccinate |
Syk | Angiogenesis; Tyrosine Kinase/Adaptors |
Lanraplenib monosuccinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans. Lanraplenib monosuccinate is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. | |||
T11824 |
Lanraplenib succinate
GS-9876 succinate |
Syk | Angiogenesis; Tyrosine Kinase/Adaptors |
Lanraplenib succinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans. Lanraplenib succinate is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. | |||
T36178 |
Aspalatone
|
Others | Others |
Aspalatone is an anti-platelet aggregator (IC50 = 180 μM, in vitro) that prolongs bleeding time significantly in a rodent model of thromboembolism. Additionally at a minimal effective dose of 24 mg/kg, aspalatone generates antioxidant and neuroprotective effects against kainic acid-induced epilepsy in rat hippocampus. | |||
T71980 |
Omeprazole acid
|
Others | Others |
Omeprazole acid is a medication used in the treatment of gastroesophageal reflux disease, peptic ulcer disease, and Zollinger–Ellison syndrome. It is also used to prevent upper gastrointestinal bleeding in people who are at high risk. Omeprazole is a proton pump inhibitor and as such blocks the release of stomach acid. | |||
T7601 |
Carbetocin
卡贝缩宫素,醋酸卡贝缩宫素 |
Oxytocin Receptor | Endocrinology/Hormones; GPCR/G Protein |
Carbetocin 是催产素类似物,是催产素受体激动剂,Ki 是 7.1 nM。它对催产素受体的嵌合 N 末端具有高亲和力,Ki 为 1.17 μM。它能透过血脑屏障,可以通过激活 CNS 中的催产素受体而具有类抗抑郁活性,具有用于产后出血的研究潜力。 | |||
T64257 |
FXIa-IN-8
|
Others | Others |
FXIa-IN-8 是一种有效的、选择性的 FXIa 抑制剂 (IC50: 14.2 nM)。FXIa-IN-8 表现出抗血栓形成效果,而且不会提高出血风险及明显的毒性 sup>[1]。 | |||
T28099 |
MRS2179
MRS 2179,MRS-2179 |
Others | Others |
MRS2179 is a competitive P2Y1 receptor antagonist (Kb = 100 nM) with no appreciable activity at P2Y2, P2Y4, or P2Y6 at concentrations up to 30 µM, or at P2Y12 and P2Y13. It inhibits ADP-induced platelet shape change and aggregation (pA2 = 6.55) in vitro a | |||
T74647 |
BT5528
|
Others | Others |
BT5528 是一种双环肽毒素结合物,一种EphA2激活剂。BT5528 由双环肽和AuristatinE 组成,是 BCY6099 的衍生物。BT5528 在大鼠模型中显示出强大的抗肿瘤活性,不导致出血或引起凝血毒性。 | |||
T36553 |
Thrombin Receptor Peptide Ligand (trifluoroacetate salt)
|
Others | Others |
Thrombin receptor peptide ligand is antagonist of the thrombin receptor (EC50s = 16-33 μM to inhibit platelet aggregation in vitro). It inhibits α-thrombin and platelet aggregation induced by thrombin receptor activating peptide in vitro when used at a concentration of 32 μM but does not affect platelet aggregation induced by ADP or collagen. It also inhibits thrombin- and TRAP-induced proliferation of vascular smooth muscle cells (VSMCs). Thrombin receptor peptide ligand (100 μmol/kg bolus, i.v... | |||
T79847 |
Frunexian
EP-7041 |
Factor Xa | Metabolism |
Frunexian (EP-7041) 为针对 Factor XIa 的选择性有效凝血因子 XI/活化因子 XI 抑制剂,展现抗血栓活性,且在大鼠肠系膜动脉穿刺模型中显示出无出血倾向。此化合物亦可应用于体外膜氧合(ECMO)的研究领域。 | |||
T72113 |
6-Aminocaproic acid hydrochloride
EACA hydrochloride,EACA hydrochloride ; Epsilon-Amino-n-caproic Acid hydrochloride ; 6-Aminohexanoic acid hydrochloride,6-Aminohexanoic acid hydrochloride,Epsilon-Amino-n-caproic Acid hydrochloride |
Others | Others |
6-Aminocaproic acid hydrochloride,一种单氨基羧酸,作为有效及口服活性的纤溶酶和纤溶酶原抑制剂,具备显著的抗纤溶能力。通过竞争性结合纤溶酶原上的赖氨酸残基,6-Aminocaproic acid hydrochloride 阻止血块溶解,抑制纤溶酶生成,减少纤维蛋白溶解,用于出血性疾病研究。 | |||
T38178 |
Ristocetin A (sulfate)
Ristomycin III |
Others | Others |
Ristocetin A, a glycopeptide related to vancomycin, is an antibiotic produced by the microorganism Nocardia lurida[1]. Ristocetin A is currently in clinical use to treat bacterial infections [1]. Ristocetin A is an antibiotic which can be used to treat staphylococcal infections. The side effects of ristocetin A include thrombocytopenia and platelet agglutination. Ristocetin A has been used in two assays: the ristocetin cofactor assay and the ristocetin-induced platelet aggregation assay. These t... | |||
T36660 |
Olsalazine-13C6
Olsalazine-13C6 |
Others | Others |
Olsalazine-13C6is intended for use as an internal standard for the quantification of olsalazine by GC- or LC-MS. Olsalazine is an orally bioavailable prodrug form of the anti-inflammatory agent 5-aminosalicylic acid that is cleaved by bacterial azo reductases in the gut to generate active 5-ASA.1In vitro, olsalazine increases ion transport in isolated rabbit distal ileum when applied to the luminal side (ED50= 0.3 mM) and stimulates fluid transport in rat jejunum when used at a concentration of ... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0881 |
6-Aminocaproic acid
氨基己酸,EACA,6-氨基己酸,6-Aminohexanoic acid,Epsilon-Amino-n-caproic Acid,(6-)ε-Aminocaproic acid |
Others | Others |
6-Aminocaproic acid (EACA) 是一种单氨基羧酸,是一种有效的、具有口服活性的纤溶酶和纤溶酶原的抑制剂。它是一种有效的抗纤维蛋白溶解剂,能够竞争性结合纤溶酶原上的赖氨酸残基,防止血块溶解,并抑制纤溶酶的形成,减少纤维蛋白溶解。它可用于出血性疾病的研究。 | |||
T14865 |
Carboprost tromethamine
|
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Carboprost tromethamine 是合成的前列腺素 F2α的15-甲基类似物,能有效促进子宫的规律收缩,显着减少产中及产后出血量。 | |||
T13693 |
Fibrin
|
Others | Others |
Fibrin 是血凝块的主要成分,为一种不溶性蛋白质,对凝血过程至关重要。这种蛋白质从牛血中分离出来,特别是在出血时合成。 | |||
TN7238L |
Sanguinarine citrate
Sanguinarium citrate,Sanguinarin citrate,Pseudochelerythrine citrate |
Antibiotic | Microbiology/Virology |
Sanguinarine citrate (Pseudochelerythrine chloride) 是一种来源于 Sanguinaria Canadensis 的生物碱,具有抗菌、抗炎和镇痛活性,可用于治疗口腔炎、牙龈出血和喉炎等口腔炎症疾病 。 | |||
T80680 |
γ-Isofagarine
Iso-γ-fagarine |
||
Isofagarine (Iso-γ-fagarine) 为一生物碱,源自Dictamnus angustifolius根皮。该化合物参与风湿、出血、瘙痒、黄疸、慢性肝炎和皮肤病等病态研究。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00238 |
Lefty-A Protein, Human, Recombinant (His)
Endometrial bleeding-associated factor,TGFB4,TGF-β-... |
Human | HEK293 Cells |
Left-right determination factor 2(LEFTY2) is a secreted protein which belongs to the TGF-beta family. Lefty was first identified in a screen for undifferentiated cell-specific cDNAs from the P19 mouse embryonal carcinoma cells. Its mRNA expression on the left side of the developing embryo earned the name “Lefty”. The human orthologue was initially identified as Ebaf, Endometrial bleeding associated factor. Lefty contains the six cysteine residues that are conserved among TGF-β related proteins a... | |||
TMPY-02185 |
Coagulation factor XIII B/F13B Protein, Human, Recombinant (His)
Coagulation factor 13,coagulation factor XIII, B polypeptide... |
Human | HEK293 Cells |
Coagulation factor XIII B chain, also known as Fibrin-stabilizing factor B subunit, Protein-glutamine gamma-glutamyltransferase B chain, Transglutaminase B chain and F13B, is a secreted protein which contains 1 Sushi ( CCP / SCR ) domains. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have en... | |||
TMPY-01104 |
Coagulation factor XI/F11 Protein, Human, Recombinant (His)
coagulation factor 11,coagulation factor XI,FXI |
Human | HEK293 Cells |
Factor XI (plasma thromboplastin antecedent) is a plasma glycoprotein, and a zymogen acting as a serine protease which participates in blood coagulation as a catalyst in the conversion of factor IX to factor IXa in the presence of calcium ions. It is an unusual dimeric protease, with structural features that distinguish it from vitamin K-dependent coagulation proteases. The factor XI is synthesized in the liver as a single polypeptide chain with a molecular weight estimated between 125 ~160 kDa ... | |||
TMPY-01101 |
Coagulation factor X/F10 Protein, Human, Recombinant (His)
FXA,FX,coagulation factor X,coagulation factor 10 |
Human | Baculovirus Insect Cells |
Coagulation factor X, also known as FX, F10, Eponym Stuart-Prower factor, and thrombokinase, is an enzyme of the coagulation cascade. It is one of the vitamin K-dependent serine proteases, and plays a crucial role in the coagulation cascade and blood clotting, as the first enzyme in the common pathway of thrombus formation. Factor X deficiency is one of the rarest of the inherited coagulation disorders. FX deficiency among the most severe of the rare coagulation defects, typically including hema... | |||
TMPY-00990 |
Lefty-A Protein, Human, Recombinant (hFc)
LEFTYA,left-right determination factor 2,LEFTA,TGFB4,EBAF |
Human | HEK293 Cells |
left-right determination factor 2 (Lefty2), also known as Left-right determination factor A (Lefty A), endometrial bleeding associated factor (left-right determination, factor A transforming growth factor-beta superfamily), and transforming growth factor beta-4, is a member of the TGF-beta family of proteins. This protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. Lefty2/Lefty A may also play a role in endometrial bleeding. Mutations i... | |||
TMPY-02014 |
Coagulation factor VII/F7 Protein, Human, Recombinant (His)
coagulation factor VII (serum prothrombin conversion acceler... |
Human | HEK293 Cells |
Coagulation factor VII, also known as Serum prothrombin conversion accelerator, Factor VII, F7 and FVII, is a member of the peptidase S1 family. Factor VII is one of the central proteins in the coagulation cascade. It is an enzyme of the serine protease class, and Factor VII (FVII) deficiency is the most frequent among rare congenital bleeding disorders. Factor VII contains two EGF-like domains, one Gla (gamma-carboxy-glutamate) domain and one peptidase S1 domain. The main role of factor VII is ... | |||
TMPU-00002 |
SOS1-Cat Protein, Human, Recombinant (His)
SOS-1,Son of sevenless homolog 1 |
Human | E. coli |
Defects in SOS1 are the cause of gingival fibromatosis 1 (GGF1) [MIM:135300]; also known as GINGF1. Gingival fibromatosis is a rare overgrowth condition. Defects in SOS1 are the cause of Noonan syndrome type 4 (NS4) [MIM:610733]. NS4 is an autosomal dominant disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. It is a genetically heterogeneous and relatively common syndrome, with an estimated incid... | |||
TMPJ-00605 |
GPVI Protein, Mouse, Recombinant (His)
Glycoprotein 6,GP6,glycoprotein VI (platelet),GPVI,GPIV,MGC1... |
Mouse | HEK293 Cells |
Glycoprotein VI (GPVI) is a 63 kDa platelet/megakaryocyte-specific type I transmembrane glycoprotein of the immunoglobulin superfamily that is an important collagen receptor and initiator of platelet activation, aggregation and thrombin generation. GPVI is also a secondary receptor required for platelet spreading on laminin. GPVI associates with the Fc receptor gamma -chain via charged aa in the TM domains of GPVI (arginine) and the FcR gamma (aspartic acid). Collagen binding by the GPVI Ig-like... | |||
TMPJ-00535 |
F13A Protein, Human, Recombinant (His)
F13A1,Coagulation Factor XIII A Chain,Transglutaminase A Cha... |
Human | HEK293 Cells |
Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is composed of just 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium io... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMID-0131 |
Norethindrone-2,2,4,6,6,10-d6
|
||
Norethindrone-2,2,4,6,6,10-d6 是 Norethindrone 的氘代化合物。Norethindrone 的 CAS 号为 68-22-4。Norethindrone 是孕激素,能够用于子宫内膜异位症、由激素水平异常引起的子宫出血和继发性闭经的研究。 | |||
TMIJ-0382 |
Norethindrone (Ethynyl-13C2)
|
||
Norethindrone (Ethynyl-13C2) 是 Norethindrone 的 13C 的标记化合物。Norethindrone 的 CAS 号为 68-22-4。Norethindrone 是孕激素,能够用于子宫内膜异位症、由激素水平异常引起的子宫出血和继发性闭经的研究。 |