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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T16967 |
T-00127_HEV1
|
PI4K | PI3K/Akt/mTOR signaling |
T-00127_HEV1 是有效的phosphatidylinositol 4-kinase III beta 抑制剂,IC50为 60 nM。 | |||
T18993 |
Fluorescein di-beta-D-galactopyranoside
FDG,Fluorescein di(β-D-galactopyranoside) |
Others | Others |
Fluorescein di-beta-D-galactopyranoside (FDG) 是通过流式细胞术检测动植物中β-半乳糖苷酶的荧光底物 ,λex=485 nm,λem=535 nm。 | |||
T17260 |
WWL70
|
Lipase; MAGL | Metabolism |
WWL70 是选择性 α/β 水解酶结构域 6 抑制剂,其IC50=70 nM。 | |||
T2098 |
A 77-01
A77-01 |
ALK; TGF-beta/Smad | Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors |
A 77-01 是 TGF-βI 型受体家族 ALK5抑制剂(IC50:25 nM)。 | |||
T16530 |
BF738735
|
Antiviral; PI4K | Immunology/Inflammation; PI3K/Akt/mTOR signaling |
BF738735 是有效的磷脂酰肌醇 4-激酶 IIIβ 抑制剂,IC50为 5.7 nM。 | |||
T1671 |
Mirabegron
YM178,米拉贝隆 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Mirabegron (YM178) 是选择性的肾上腺素受体激动剂,EC50=22.4 nM。 | |||
T13253 |
Umibecestat
CNP520 |
BACE | Neuroscience |
Umibecestat 是一种β-位点淀粉样前体蛋白裂解酶-1 (BACE-1) 抑制剂,对人 BACE-1 和小鼠 BACE-1 的 IC50 分别为 11 nM 和 10 nM,可用于阿尔茨海默病的研究。 | |||
T0154 |
Nebivolol hydrochloride
R 065824 hydrochloride,盐酸奈必洛尔,Nebivolol HCl,R-65824 |
Apoptosis; Adrenergic Receptor | Apoptosis; GPCR/G Protein; Neuroscience |
Nebivolol hydrochloride (R 065824 hydrochloride) 是一种β1-肾上腺素受体选择性抑制剂,IC50为0.8 nM。 | |||
T22694 |
CRANAD 2
|
Others | Others |
CRANAD 2 是一种特异性近红外 (NIR) 荧光探针,可用于检测 Aβ 斑块。它可透过血脑屏障,且对 Aβ 聚集体有高亲和性,其 Kd=38 nM。 | |||
T0277 |
Metaproterenol hemisulfate
Orciprenaline sulfate,Metaproterenol Sulfate,硫酸奥西那林 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Metaproterenol hemisulfate (Orciprenaline sulfate) 是一种 β2-肾上腺素能受体 (β2AR) 激动剂(IC50=68 nM),是一种直接作用的拟交感神经药,具有抗炎活性。 | |||
T1800 |
GW788388
GW 788388 |
ALK; TGF-beta/Smad | Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors |
GW788388 是一种 ALK5抑制剂(IC50:18 nM)。它也抑制 TGF-β II 型受体和激活素 II 型受体的活性,但对 BMP II 型受体无影响。 | |||
T1527 |
Gliclazide
格列齐特,S1702,SE1702 |
Potassium Channel | Membrane transporter/Ion channel |
Gliclazide (SE1702) 是一种有效的全细胞的 β 细胞 ATP 敏感型钾流阻断剂,IC50为 184 nM,用作降糖药。 | |||
T6870 |
L-685458
L-685,458 |
Apoptosis; Gamma-secretase | Apoptosis; Neuroscience; Proteases/Proteasome; Stem Cells |
L-685458 (L-685,458) 是一种过渡状态模拟 γ-分泌酶抑制剂,抑制淀粉样 β-蛋白前体 γ-分泌酶活性,选择性高于其他检测的天冬氨酸蛋白酶 50-100 倍。它抑制 γ-分泌酶介导的 APP-C99 和 Notch-100 的裂解,可研究阿尔茨海默病和癌症。 | |||
T2265 |
Bimiralisib
5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine,PQR309,PI3K-IN-2 |
Others; PI3K; S6 Kinase; mTOR | MAPK; Others; PI3K/Akt/mTOR signaling |
Bimiralisib (PI3K-IN-2) 是一种有效的,可渗透脑的 mTOR/PI3K 抑制剂,是一种 mTORC1和 mTORC2抑制剂。它能够抑制 PI3Kα,PI3Kδ,PI3Kβ,PI3Kγ和 mTOR,IC50分别为 33 nM,451 nM,661 nM,708 nM 和 89 nM。 | |||
T6496 |
Vactosertib
TEW-7197,EW-7197 |
ALK; TGF-beta/Smad | Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors |
Vactosertib (EW-7197) 是有效的、具有 ATP 竞争性的、具有口服活性的激活素受体样激酶 5 (ALK5) 抑制剂(IC50:12.9 nM)。它还以纳摩尔浓度抑制 ALK2 和 ALK4 (IC50为 17.3 nM),表现出强大的抗转移活性和抗癌作用。 | |||
T22245 |
Arformoterol Tartrate
(R,R)-Formoterol tartrate,酒石酸福莫特罗 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Arformoterol Tartrate ((R,R)-Formoterol tartrate) 是一种长效 β2-肾上腺素能受体 (β2-AR) 激动剂,Kd=2.9 nM。它是一种 Formoterol 的 (R,R)-对映异构体,可用于慢性阻塞性肺疾病 (COPD) 的研究。 | |||
T6604 |
Nepicastat hydrochloride
Nepicastat HCl,内匹司他盐酸盐,RS-25560-197 hydrochloride,SYN-117 hydrochloride,Nepicastat (SYN-117) HCl |
Hydroxylase | Metabolism |
Nepicastat hydrochloride (RS-25560-197 hydrochloride) 是一种选择性的,有效的,口服活性的多巴胺 β 羟化酶(dopamine-beta-hydroxylase)抑制剂,对牛和人多巴胺 β 羟化酶的IC50分别为IC50=8.5 nM 和IC50=9 nM。Nepicastat HCl 可以穿过血脑屏障。 | |||
T1349 |
5-Fluorouridine
|
Others; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others |
5-Fluorouridine 是一种 5-fluorouracil 的代谢物,具有抗癌作用。它对 L1210 细胞的生长具有细胞毒性作用,其作用的 IC50值为 2 nM。它能抑制人结肠癌细胞 rRNA 的合成。 | |||
T4978 |
Sarpogrelate hydrochloride
盐酸沙格雷酯,MCI-9042 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Sarpogrelate hydrochloride (MCI-9042) 是一种选择性5-HT2R 拮抗剂,可用于研究与血栓形成有关的血管疾病,对 5-HT2A、5-HT2B 和 5-HT2C 受体的pKi 值分别为 8.52、6.57 和 7.43。 | |||
T0866 |
Propafenone
Rythmol,普罗帕酮,Propafenonum |
Potassium Channel; MRP; Sodium Channel | Immunology/Inflammation; Membrane transporter/Ion channel |
Propafenone (Propafenonum) 是钠通道阻滞剂,它对 β 受体具有高亲和力 (IC50=32 nM)。它能够阻断瞬时外向钾电流 (Ito) (IC50: 4.9 nM) 和持续延迟整流器K+电流 (Isus) (IC50: 8.6 nM) ,具有抗心律失常的作用。它能够诱导线粒体功能障碍及诱导细胞凋亡,从而抑制食管癌增殖。 | |||
T63013 |
Ruboxistaurin
|
Others | Others |
Ruboxistaurin (LY333531) 是一种选择性的、口服具有活力的 PKC beta 抑制剂,其 Ki 值为 2 nM。Ruboxistaurin 以 ATP 依赖性的方式竞争性抑制 PKC beta I (IC50: 4.7 nM)。Ruboxistaurin 能够作用于 PKC beta II (IC50: 5.9 nM)。 | |||
T12467 |
PI4KIII beta inhibitor 3
|
PI3K | PI3K/Akt/mTOR signaling |
PI4KIII beta inhibitor 3 is a novel and high effective inhibitor of PI4KIIIβ (IC50 of 5.7 nM). | |||
T24380 |
L-796568 free base
|
Others | Others |
L-796568 free base is a β3 adrenergic receptor agonist potentially for the treatment of obesity. L-796568 is a potent full beta(3) agonist (EC50: 3.6 nM). It has 600-fold selectivity over the human beta(1) and beta(2) receptors. | |||
T29034 |
U75302
U 75302,U-75302 |
Others | Others |
U75302 is an antagonist of thymosin beta-4 (TB4) receptor with a Ki value of 159 nM on guinea pig lung membranes. | |||
T10014 |
(1α,1'S,4β)-Lanabecestat
(1α,1'S,4β)-AZD3293 |
Others | Others |
(1α,1'S,4β)-Lanabecestat is a Beta site APP Cleaving Enzymel (BACE1) inhibitor, and has IC50s of 2.2 nM (TR-FRET assay) and 0.28 nM (sAPPp release assay), respectively. | |||
T27786 |
L-796568 dihydrochloride
L 796568,L-796568,L796568 |
Others | Others |
L-796568, is a β3 adrenergic receptor agonist. L-796568 is a potent full beta(3) agonist (EC(50) = 3.6 nM, 94% activation) with >600-fold selectivity over the human beta(1) and beta(2) receptors, which also displays good oral bioavailability in several | |||
T11243 |
Ethyl tosylcarbamate
|
Others | Others |
Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM. Ethyl tosylcarbamate is an intermediate in the synthesis of Gliclazide (G409877). | |||
T60633 |
Nepicastat
|
Others | Others |
Nepicastat (SYN117) 是一种选择性的,有效的,口服的多巴胺 β 羟化酶抑制剂,可穿过血脑屏障(BBB)。Nepicastat (SYN117) 对牛和人多巴胺 β 羟化酶产生浓度依赖性抑制作用,IC50值分别为8.5 nM 和 9 nM。 | |||
T31828 |
AZD4694
Flutafuranol,AZD 4694,NAV-4694,AZD-4694,NAV 4694,NAV4694 |
Others | Others |
Flutafuranol, also known as AZD 4694 and NAV4694, is a bio-active chemical. AZD4694 shows high affinity for beta-amyloid fibrils in vitro (K(d) = 2.3 +/- 0.3 nM). The fluorine-18 labeled AZD4694 may have potential for PET-visualization of cerebral beta-am | |||
T72261 |
Metallo-β-lactamase-IN-9
|
Others | Others |
Metallo-β-lactamase-IN-9 (Compound 23) 是一种高效的泛金属-β-内酰胺酶 (MBL) 抑制剂,其对 NDM-1、VIM-1 和 IMP-1 的抑制活性表现在 IC50 值上,分别为 35 nM、269 nM 和 369 nM。 | |||
T74786 |
BIBD-124
|
Others | Others |
BIBD-124 通过与淀粉样蛋白 (Aβ) 斑块结合,展现出优异的亲和力,其 IC50 值达到了 9.51 nM。作为一种放射性示踪剂,[18F]BIBD-124 能够针对 Aβ 斑块进行高效的标记。 | |||
T36296 |
BIO5192 hydrate
|
Others | Others |
BIO5192 hydrate is a selective and potent integrin α4β1 (VLA-4) inhibitor (Kd<10 pM). BIO5192 hydrate selectively binds to α4β1 (IC50=1.8 nM) over a range of other integrins. BIO5192 hydrate results in a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels[1][2]. The combination of BIO5192 hydrate (1 mg/kg; i.v.) and Plerixafor (5 mg/kg; s.c.) exert an additive effect on progenitor mobilization[1].BIO5192 hydrate (30 mg/kg; s.c; bid; during days... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4721 |
β-Nicotinamide mononucleotide
NMN,β-NM,β烟酰胺单核苷酸,烟酰胺单核苷酸 |
Others; Endogenous Metabolite | Metabolism; Others |
β-nicotinamide mononucleotide 是烟酰胺磷酸核糖转移酶 (NAMPT) 反应的产物。β-nicotinamide mononucleotide的作用包括其在细胞生化功能、心脏保护、糖尿病、肥胖相关并发症和阿尔茨海默病中的作用。 | |||
TJS0341 |
7-Amino-4-(trifluoromethyl)coumarin
香豆素151,Coumarin 151,AFC,7-氨基-4-(三氟甲基)香豆素 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
7-Amino-4-(trifluoromethyl)coumarin (Coumarin 151) 是一种荧光标记物,其激发和发射波长分别为400和500 nm,可用来灵敏的检测蛋白酶。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-03037 |
Alpha-cobratoxin Protein, Naja kaouthia, Recombinant (GST & His & Myc)
Alpha-CT,Alpha-Ctx,Alpha-EPTX-Nk2a,Long neurotoxin 1,Alpha-C... |
Naja kaouthia | E. coli |
Monomer: binds with high affinity to muscular (alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND) nAChR (tested on Torpedo californica, Kd=0.2-4.5 nM) and neuronal alpha-7/CHRNA7 nicotinic acetylcholine receptors (Kd=13-105 nM). Also inhibits GABA(A) channels. Heteropentamer targets studied are composed of alpha-1-beta-3-gamma-2 (GABRA1-GABRB3-GABRG2) subunits (IC(50)=236 nM), alpha-1-beta-2-gamma-2 (GABRA1-GABRB2-GABRG2) subunits (IC(50)=469 nM), alpha-2-beta-2-gamma-2 (GABRA2-GABRB2-GABRG2)... | |||
TMPH-02408 |
SPI Protein, Lentinula edodes, Recombinant (His)
Serine protease inhibitor |
Lentinula edodes | E. coli |
Serine protease inhibitor. Active against beta-trypsin and alpha-chymotrypsin with dissociation constants of 0.35 nM and 40 nM respectively. Inhibits factor XIa, but not other enzymes involved in coagulation and fibrinolysis. Does not inhibit subtilisin, lysyl endopeptidase, arginyl endopeptidase or papain. | |||
TMPH-00031 |
Aerolysin Protein, Aeromonas sobria, Recombinant (His & Myc)
Hemolysin |
Aeromonas sobria | E. coli |
Secreted, cytolytic toxin that forms pores in host membranes after proteolytic removal of a C-terminal propeptide, leading to destruction of the membrane permeability barrier and cell death. The pores are formed by transmembrane beta-strands and are approximately 3 nm in diameter. | |||
TMPY-01660 |
SULT1E1 Protein, Human, Recombinant (His)
ST1E1,EST,sulfotransferase family 1E member 1,EST-1,STE,MGC3... |
Human | E. coli |
Estrogen sulfotransferase, also known as Sulfotransferase, estrogen-preferring, Sulfotransferase 1E1, SULT1E1 and ST1E1, is a cytoplasm enzyme that belongs to the sulfotransferase 1 family. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. SULT1E1 may control the level of the estrogen receptor by sulfurylating free estradio... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIH-0253 |
Gliclazide-d7
|
||
Gliclazide-d7 是 Gliclazide 的氘代化合物。Gliclazide 的 CAS 号为 21187-98-4。Gliclazide 是一种有效的全细胞的 β 细胞 ATP 敏感型钾流阻断剂,IC50为 184 nM,用作降糖药。 | |||
TMIJ-0272 |
Sarpogrelate-d3 HCl
|
||
Sarpogrelate-d3 HCl 是 Sarpogrelate HCl 的氘代化合物。Sarpogrelate HCl 的 CAS 号为 135159-51-2。Sarpogrelate hydrochloride 是一种选择性5-HT2R拮抗剂,可用于研究与血栓形成有关的血管疾病,对 5-HT2A、5-HT2B 和 5-HT2C 受体的pKi值分别为 8.52、6.57 和 7.43。 |