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Search Results for " antituberculosis "

22

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9995	Antituberculosis agent-5	Others	Others
	Antituberculosis agent-5是一种用于高通量测定的小分子。
T61222	Antituberculosis agent-1	Others	Others
	Antituberculosis agent-1 (Compound 8a) 是一种抗结核剂，对 M. tuberculosisH37Rv 的 MIC 值为 3.84 μg/mL。
T75019	Antituberculosis agent-7	Others	Others
	Antituberculosis agent-7 是一种氧杂环丁基喹啉衍生物，对P. mirabilis 具有良好的抗菌活性，MIC 为 31.25 μM。Antituberculosis agent-7 对A. niger 显示出良好的抗真菌活性，MIC 为 62.5 μM。Antituberculosis agent-7 显示出优异的抗分枝杆菌活性，对结核分枝杆菌 H37Rv 的 MIC 为 3.41 μM。
T72262	Antituberculosis agent-6	Others	Others
	Antituberculosis agent-6 是一种有效的抗结核分枝杆菌 (antimycobacterial) 剂。Antituberculosis agent-6 对M. tuberculosis 显示出显著的抑制活性，MIC 为 3.49 μM。Antituberculosis agent-6 还对A. niger 表现出良好的抗真菌 (antifungal) 活性，MIC 为 62.50 μM。 Antituberculosis agent-6 表现出高胃肠道吸收。
T60879	Antituberculosis agent-2	Others	Others
	Antituberculosis agent-2 (Compound 8d) 是一种针对耐多药结核病和药物敏感结核病均有效的抗结核剂。Antituberculosis agent-2 在小鼠和人类中显示出良好的微粒稳定性，具有低细胞毒性和可接受的口服生物利用度。Antituberculosis agent-2 具有抗结核活性。Antituberculosis agent-2 对结核分枝杆菌 H37Rv、13946 和 14862 的 MIC 值分别为0.454、1.757 和 1.644 μg/mL。
T63286	Antituberculosis agent-3	Others	Others
	Antituberculosis agent-3 是一种具有抗霉菌作用的抗结核剂，对结核杆菌 H37Rv 株的生长具有抑制作用，其 MIC 值为 12.5 μg/mL。
T74769	Antituberculosis agent-9	Others	Others
	Antituberculosis agent-9 (Compound 5a) 是一种具有口服活性的抗结核剂，对H37Ra 的MIC 为 0.5 μg/mL。
T72263	Antituberculosis agent-8	Others	Others
	Antituberculosis agent-8 是一种抗结核剂，对M. tuberculosis H37Rv 的 MIC 值为 3.53 μM (1.6 μg/mL)。Antituberculosis agent-8 对A. niger 也显示出良好的抗真菌 (antifungal) 活性，MIC 为 62.50 μM。
T3583	Macozinone PBTZ169	Antibacterial; DprE1	Microbiology/Virology; Others
	Macozinone (PBTZ169) 是具有杀菌作用的苯并噻嗪酮，也有抗结核作用。它也是一种 DprE1有效抑制剂，可通过与活性位点 Cys387 残基形成共价键来抑制必需的黄素蛋白 DprE1。
T4044	DprE1-IN-2	Antibacterial; DprE1	Microbiology/Virology; Others
	DprE1-IN-2 是 DprE1抑制剂，IC50为 28 nM，有抗结核作用。
T3224	TBA-7371 AZ 7371,DprE1-IN-1	Antibacterial; PDE; DprE1	Metabolism; Microbiology/Virology; Others
	TBA-7371 (DprE1-IN-1) 是一种非共价 DprE1有效抑制剂，具有强大的抗结核活性。
T0827	Cefsulodin sodium Cefsulodine sodium,Sulcephalosporin,头孢磺啶钠	Antibacterial; Antibiotic	Microbiology/Virology
	Cefsulodin sodium (Sulcephalosporin) 是β内酰胺抗生素，对缘脓杆菌和肠杆菌有活性。
T60774	NITD-916 NITD916,NITD 916	Antibiotic	Microbiology/Virology
	NITD-916 是一种具有口服活性和高度亲脂性的分枝杆菌烯酰还原酶 InhA 抑制剂，IC50 为 570 nM。NITD-916是一种有有效的 4-羟基-2-吡啶酮衍生物，与 InhA 和 NADH 形成三元复合物，阻止进入脂肪酰基底物结合袋。NITD-916 具有抗结核活性。
T24691	Q151 Q-151,Q 151	Others	Others
	Q151 is an IMPDH inhibitor. It also is a potential antituberculosis agent.
T79288	Antitubercular agent-38	Others	Others
	Antitubercula agent-38，一种具有效抗结核活性的口服苯并噻嗪酮(BTZ)衍生物，其特点为低心脏毒性和低细胞毒性。
T82571	DHFR-IN-10	Others	Others
	DHFR-IN-10（化合物4c）是针对结核分枝杆菌DHFR的高效抑制剂，其IC50为4.21 μM，显示出卓越的抗结核活性。
T36467	Chrysomycin A	Others	Others
	Chrysomycin A 是一种可来自链霉菌的抗生素。在胶质母细胞瘤中，Chrysomycin A 通过 Akt/GSK-3β/β-catenin 信号通路抑制癌细胞的增殖、迁移和侵袭。表现出抗肿瘤和抗结核和 MRSA 活性。
T79479	MptpB-IN-2	Antibiotic	Microbiology/Virology
	MptpB-IN-2（化合物20）是一种高选择性的结核分枝杆菌蛋白酪氨酸磷酸酶B（MptpB）抑制剂，其对MptpB、MptpA和PTP1B的IC50值分别为0.64 μM、4.06 μM和4.14 μM。此化合物对Mtb H37Rv表现出较低的抗结核活性，MIC为64.9 μM。
T37880	OPC-167832	Others	Others
	OPC-167832 is a potent and orally active dprE1 Inhibitor with an IC50 of 0.258 μM. OPC-167832 has antituberculosis activity and can be used for the research of tuberculosis caused by Mycobacterium tuberculosis[1]. OPC-167832 exhibits very low MICs against laboratory strains of M. tuberculosis H37Rv (MIC: 0.0005 μg/ml) and Kurono (MIC: 0.0005 μg/ml) and strains with monoresistance to rifampin (RIF), isoniazid (INH), ethambutol (EMB), streptomycin (STR), and pyrazinamide (PZA) (MIC: 0.00024-0.001 ...
T11449	Golotimod hydrochloride (229305-39-9 free base) Golotimod hydrochloride,Gamma-D-glutamyl-L-tryptophan hydrochloride,SCV 07 hydrochloride	STAT	JAK/STAT signaling; Stem Cells
	Golotimod (SCV 07) hydrochloride 是一种免疫调节肽，具抗菌活性，能显著提升抗结核疾病研究效果。该化合物通过刺激胸腺和脾细胞增殖、改善巨噬细胞功能，展现其生物调节能力。此外，Golotimod hydrochloride 通过抑制STAT3信号传导，有效调节接受放疗或与顺铂联用治疗动物模型中的口腔粘膜炎持续时间和严重程度。还显示出对研究复发性生殖器单纯疱疹病毒 2 型 (HSV-2) 具有潜在应用价值。
T37537	Carbazomycin D	Others	Others
	Carbazomycin D is a bacterial metabolite that has been found inStreptomycesand has diverse biological activities.1,2It is active against the fungiT. asteroidesandT. mentagrophytes(MIC = 100 μg/ml for both) and the bacteriumM. tuberculosis(IC50= 25 μg/ml). Carbazomycin D is cytotoxic to MCF-7, KB, NCI H187, and Vero cells (IC50s = 21.3, 33.2, 12.9, and 34.3 μg/ml, respectively).2 1.Naid, T., Kitahara, T., Kaneda, M., et al.Carbazomycins C, D, E and F, minor components of the carbazomycin complexJ...
T37536	Carbazomycin A	Others	Others
	Carbazomycin A is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities.1,2It is active againstS. aureus,T. asteroides, andT. mentagrophytes(MIC = 12.5 μg/ml for all), as well as the plant pathogenic fungusP. oryzae(MIC = 25 μg/ml). Carbazomycin A is cytotoxic to MCF-7, KB, NCI H187, and Vero cells (IC50s = 26.2, 30.1, 18.4, and 32.6 μg/ml, respectively).2 1.Sakano, K.-I., Ishimaru, K., and Nakamura, S.New antibiotics, carbazomycins A and B. I. Fermenta...

化合物

Antituberculosis agent-5

Cat.No: T9995

Target: Others

Antituberculosis agent-1

Cat.No: T61222

Target: Others

Antituberculosis agent-7

Cat.No: T75019

Target: Others

Antituberculosis agent-6

Cat.No: T72262

Target: Others

Antituberculosis agent-2

Cat.No: T60879

Target: Others

Antituberculosis agent-3

Cat.No: T63286

Target: Others

Antituberculosis agent-9

Cat.No: T74769

Target: Others

Antituberculosis agent-8

Cat.No: T72263

Target: Others

Cat.No: T3583

Synonym: PBTZ169

Target: Antibacterial, DprE1

Cat.No: T4044

Target: Antibacterial, DprE1

Cat.No: T3224

Synonym: AZ 7371,DprE1-IN-1

Target: Antibacterial, PDE, DprE1

Cefsulodin sodium

Cat.No: T0827

Synonym: Cefsulodine sodium,Sulcephalosporin,头孢磺啶钠

Target: Antibacterial, Antibiotic

Cat.No: T60774

Synonym: NITD916,NITD 916

Target: Antibiotic

Cat.No: T24691

Synonym: Q-151,Q 151

Target: Others

Antitubercular agent-38

Cat.No: T79288

Target: Others

Cat.No: T82571

Target: Others

Cat.No: T36467

Target: Others

Cat.No: T79479

Target: Antibiotic

Cat.No: T37880

Target: Others

Golotimod hydrochloride (229305-39-9 free base)

Cat.No: T11449

Synonym: Golotimod hydrochloride,Gamma-D-glutamyl-L-tryptophan hydrochloride,SCV 07 hydrochloride

Target: STAT

Cat.No: T37537

Target: Others

Cat.No: T37536

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T4753	Imidazoleacetic acid hydrochloride I4AA,(4-Imidazolyl)acetic acid hydrochloride,4-咪唑乙酸盐酸盐,4-Imidazoleacetic acid hydrochloride	Endogenous Metabolite; Antibiotic	Metabolism; Microbiology/Virology
	Imidazoleacetic acid hydrochloride (I4AA) 是咪唑衍生物，具有潜在的抗结核性能。它还用于制备β-分泌酶的酰基胍抑制剂。
T1589	D-Cycloserine RO-1-9213,D-环丝氨酸	Others; Antibacterial; Antibiotic; iGluR	Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Others
	D-Cycloserine (RO-1-9213) 是一种抗生素，靶向细菌细胞壁肽聚糖生物合成酶。它是一种NMDA 部分激动剂，可以改善认知功能，可研究耐多药结核病。
T4964	steviolbioside CCRIS-6025,菊双糖甙,甜菊双糖苷	Others	Others
	Steviolbioside (CCRIS-6025) 是一种存在于甜菊叶中的罕见甜味剂。它对几种人类癌细胞有抑制作用，对乳腺癌具有潜在的研究价值。
TMA0395	Danshenxinkun D	Antifection	Microbiology/Virology
	Danshenxinkun D has antituberculosis H_(37)Rv activity in vitro.
TN4953	Sativan 三叶草	Antifection	Microbiology/Virology
	Sativan possesses a broad spectrum of antimicrobial activity against bacteria and phytopathogenic fungi, it exhibits antituberculosis activity against Mycobacterium tuberculosis H37Rv, with the MIC value of 50 ug/mL.

天然产物

Imidazoleacetic acid hydrochloride

Cat.No: T4753

Synonym: I4AA,(4-Imidazolyl)acetic acid hydrochloride,4-咪唑乙酸盐酸盐,4-Imidazoleacetic acid hydrochloride

Target: Endogenous Metabolite, Antibiotic

Cat.No: T1589

Synonym: RO-1-9213,D-环丝氨酸

Target: Others, Antibacterial, Antibiotic, iGluR

Cat.No: T4964

Synonym: CCRIS-6025,菊双糖甙,甜菊双糖苷

Target: Others

Danshenxinkun D

Cat.No: TMA0395

Target: Antifection

Cat.No: TN4953

Synonym: 三叶草

Target: Antifection

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