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Search Results for " angiotensin ii "

Targets Recommended: RAAS Others

173

抑制剂 & 化合物

8

天然产物

12

重组蛋白

11

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1528	Angiotensin I/II (1-5) Angiotensin I/II 1-5	RAAS; Others	Endocrinology/Hormones; Others
	Angiotensin I/II (1-5) 是由血管紧张素 I/II 肽转化而来，有 1-5 个氨基酸组成的多肽。血管紧张素 I 是由肾素对血管紧张素原的作用形成的，血管紧张素 I 可产生血管紧张素 II 。血管紧张素 II 用于高血压、特发性膜性肾病和肾素-血管紧张素系统的研究。
T35834L	(Sar¹)-Angiotensin II acetate	RAAS	Endocrinology/Hormones
	(Sar¹)-Angiotensin II acetate 是血管紧张素 II 的类似物，是血管紧张素 AT1 受体的特异性激动剂。它与富含脑膜的颗粒结合，Kd 为 2.7 nM。它可以刺激胚胎鸡肌细胞中的蛋白质合成和细胞生长。
TP1579	Angiotensin I/II (1-6) Angiotensin I/II 1-6	RAAS; Others	Endocrinology/Hormones; Others
	Angiotensin I/II (1-6) 是由血管紧张素 I/II 肽转化而来，含有 1-6 个氨基酸的多肽。血管紧张素 I 被血管紧张素转换酶水解，形成具有生物活性的血管紧张素 II。血管紧张素 II 用于高血压、特发性膜性肾病和肾素-血管紧张素系统的研究。
TP1017L	Angiotensin II 5-valine TFA Angiotensin II 5-valine TFA(58-49-1 free base)	RAAS	Endocrinology/Hormones
	Angiotensin II 5-valine TFA 是血管紧张素受体的激动剂。
T7575L	[Sar1, Ile8]-Angiotensin II 3TFA [Sar1, Ile8]-Angiotensin II 3TFA(37827-06-8(free base))	Others	Others
	[Sar1, Ile8]-Angiotensin II 3TFA ([Sar1, Ile8]-Angiotensin II 3TFA (37827-06-8(free base))) 是一种对血管平滑肌具有多种作用的肽。
T7575L1	[Sar1, Ile8]-Angiotensin II acetate	RAAS	Endocrinology/Hormones
	[Sar1, Ile8]-Angiotensin II acetate 可激活 NADPH 和 NADH 氧化酶，并刺激血管平滑肌细胞中超氧阴离子的形成。 [Sar1, Ile8]-Angiotensin II acetate 对血管平滑肌有多种作用，包括正常动脉的收缩和培养细胞或病变血管的肥大或增生。
T8560	Angiotensin II human acetate Ang II acetate,DRVYIHPF acetate,Angiotensin II acetate,血管紧张素II	Apoptosis; RAAS	Apoptosis; Endocrinology/Hormones
	Angiotensin II human acetate (DRVYIHPF acetate) 是血管收缩剂，是肾素/血管紧张素系统的主要生物活性肽，在调节人类血压中起着核心作用。它刺激交感神经刺激，增加醛固酮生物合成和肾脏活动。它诱导血管平滑肌细胞生长，也诱导细胞凋亡。它通过 LOX-1 依赖的氧化还原敏感途径诱导内皮细胞毛细血管形成。
T35834	(Sar1)-Angiotensin II (Sar¹)-Angiotensin II
	The substitution with Sar at position 1 of angiotensin II resulted in a partial agonistic activity.
T38697	[Tyr(P)4] Angiotensin II
	[Tyr(P)4] Angiotensin II is a peptide that exerts a multitude of effects on vascular smooth muscle. These effects include the contraction of normal arteries, as well as the induction of hypertrophy or hyperplasia in cultured cells or diseased vessels.
T7575	[Sar1, Ile8]-Angiotensin II [Sar1, Ile8]-Angiotensin II(3TFA)	RAAS; Others	Endocrinology/Hormones; Others
	[Sar1, Ile8]-Angiotensin II 是一种在血管平滑肌细胞中有多种作用（如正常动脉的收缩，培养的细胞或病变血管的肥大或增生等）的多肽，。
T36622	Angiotensin I/II (1-6) (TFA)
	Angiotensin I/II (1-6) TFA is a chemical compound comprising amino acids 1-6. It is derived from the Angiotensin I/II peptide, which is formed by the cleavage of the precursor angiotensinogen by renin. The resulting Angiotensin I is then hydrolyzed by angiotensin-converting enzyme (ACE) to produce biologically active Angiotensin II. Angiotensin II has been extensively studied for its potential applications in the treatment of Hypertension, Renin Angiotensin System, and Idiopathic Membranous Neph...
T5824	Angiotensin II (3-8), human Angiotensin IV	RAAS	Endocrinology/Hormones
	Angiotensin II (3-8), human 是活性稍弱的血管紧张素AT1受体激动剂。
TP1017	Angiotensin II 5-valine Valine angiotensin II,5-L-Valine angiotensin II,血管紧张素 Ⅱ 5-缬氨酸
	ngiotensin II 5-valine is an angiotensin II analog which is an agonist at angiotensin receptors.
TP1522	Angiotensin II (5-8), human
	Angiotensin II (5-8) is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II
TP1609	Angiotensin II (1-4), human
	Angiotensin II is a potent direct vasoconstrictor, causing arteries and veins to constrict, so leading to an increase in blood pressure. Angiotensin also potentiates the release of norepinephrine by a direct action on postganglionic sympathetic fibers.
TP1224	[Sar1, Ile8]-Angiotensin II TFA Angiotensin 2 TFA,AngiotensinII TFA
	[Sar1, Ile8]-Angiotensin II (TFA) is a peptide compound that exerts various effects on vascular smooth muscle. These effects include the contraction of normal arteries as well as the hypertrophy or hyperplasia of cultured cells or diseased vessels.
TP2464	Pentasarcosyl angiotensin II (Sar)5 aii
	Pentasarcosyl angiotensin II is a synthetic analog of angiotensin II.
T10323	Angiotensin II (3-8), human TFA	RAAS	Endocrinology/Hormones
	Angiotensin II (3-8), human (TFA) is an angiotensin AT1 receptor agonist with less activity.
TP1661	Angiotensin II (1-4), human TFA
	Angiotensin II is a potent direct vasoconstrictor, causing arteries and veins to constrict, so leading to an increase in blood pressure.
TP1929L1	Saralasin acetate(34273-10-4 free base)	RAAS	Endocrinology/Hormones
	Saralasin acetate(34273-10-4 free base) 是一种非选择性血管紧张素 II 拮抗剂。
T2531	Eprosartan Mesylate SKF-108566J,甲磺酸依普罗沙坦	RAAS	Endocrinology/Hormones
	Eprosartan Mesylate (SKF-108566J) 是一种具有选择性、竞争性血管紧张素 II 受体拮抗剂，是具有口服活性的非肽。它结合血管紧张素 II 受体，在大鼠和人类肾上腺皮质膜中的IC50值分别为 9.2 nM 和 3.9 nM，可用作降压剂。
TP2370	Angiotensin pentapeptide Angiotensin II (4-8),(Des-1,2,3)angiotensin II
	Angiotensin pentapeptide is a peptide.
T6340	Enalaprilat Dihydrate 依那普利拉二水合物,MK-422,MK-422 Dihydrate	RAAS; Autophagy	Autophagy; Endocrinology/Hormones
	Enalaprilat Dihydrate (MK-422 Dihydrate) 是一种有效的血管紧张素转化酶抑制剂，IC50为 1.94 nM。
T1461	Candesartan CV 11974,坎地沙坦	RAAS	Endocrinology/Hormones
	Candesartan (CV 11974) 是一种血管紧张素II 受体拮抗剂(IC50:0.26 nM)。
T3461	Losartan Carboxylic Acid EXP-3174,E-3174	RAAS	Endocrinology/Hormones
	Losartan Carboxylic Acid (E-3174) 是 Losartan 的活性羧酸代谢产物，是血管紧张素Ⅱ受体 1 型(AT1)拮抗剂。它能够阻断血管紧张素 II 诱导的血管平滑肌细胞反应，可以提高血浆肾素活性，降低平均动脉压。
T74142	Angiotensin II human TFA
	Angiotensin II human (Angiotensin II) TFA 作为肾素/血管紧张素系统中关键的生物活性肽，扮演着血管收缩剂的角色并在调节人体血压中发挥中心作用。其主要通过与 G 蛋白偶联受体 (GPCRs)、血管紧张素 II 1型受体 (AT1R) 和血管紧张素 II 2型受体 (AT2R) 的相互作用来介导效应，包括刺激交感神经系统、增加醛固酮的生物合成和肾脏功能。此外，Angiotensin II human TFA 促进血管平滑肌细胞的生长和 I 型及 III 型胶原在成纤维细胞中的合成，导致血管壁与心肌增厚及纤维化，并诱导细胞凋亡。还通过LOX-1依赖的氧化还原敏感路径诱导内皮细胞中的毛细血管形成。
T76634	(Sar1,Ile4,8)-Angiotensin II
	(Sar1,Ile4,8)-Angiotensin II是一种对angiotensin II type 1 receptor (AT1R)具有功能选择性的激动剂，能增强胰岛素受体 (IR) 信号和糖原合成，同时还能促进Akt和GSK3α/β的磷酸化，这一过程被胰岛素刺激所增强。
T6595	Moexipril hydrochloride 莫昔普利盐酸盐,Moexipril HCl,RS-10085,SPM 925,CI-925	Apoptosis; RAAS	Apoptosis; Endocrinology/Hormones
	Moexipril hydrochloride (Moexipril HCl) 是一种有口服活性的，不含巯基的血管紧张素转化酶抑制剂，可治疗高血压和充血性心力衰竭。
T1615	Irbesartan 厄贝沙坦,SR-47436,BMS-186295	Apoptosis; RAAS	Apoptosis; Endocrinology/Hormones
	Irbesartan (SR-47436) 是一种 1 型血管紧张素 II 受体拮抗剂，IC50为1.3 nM。
T2400	Candesartan Cilexetil TCV-116,坎地沙坦酯,坎地沙坦西酯	Apoptosis; RAAS	Apoptosis; Endocrinology/Hormones
	Candesartan Cilexetil (TCV-116) 是一种血管紧张素II 拮抗剂，可用于治疗高血压。
T28540	Ripisartan UP 269-6,UP-2696,UP 2696,UP-269-6,UP269-6	RAAS	Endocrinology/Hormones
	Ripisartan (UP-269-6) 是一种强效的特异性血管紧张素 II 受体拮抗剂，对血管紧张素 II 介导的交感神经性心动过速反应有抑制作用。
T1484L	Perindopril erbumine 培哚普利叔丁胺,培哚普利叔丁胺盐,S9490-3,Perindopril tert-butylamine salt	Apoptosis; RAAS; MRP	Apoptosis; Endocrinology/Hormones; Immunology/Inflammation
	Perindopril erbumine (S9490-3) 是一种长效血管紧张素转换酶抑制剂。
T13390	ZD 7155 hydrochloride	RAAS	Endocrinology/Hormones
	ZD 7155 hydrochloride 是血管紧张素II 受体1型 (AT1 receptor) 拮抗剂。
T0215	Losartan potassium DuP-753 potassium,洛沙坦钾,氯沙坦钾,MK 954,DuP 753	RAAS	Endocrinology/Hormones
	Losartan potassium (DuP-753 potassium) 是一种血管紧张素 II 受体 1 型(AT1)拮抗剂，能够与血管紧张素 II 与 AT1 的结合竞争,其 IC50=20 nM。
T27762	L-162,313 L-162313,L 162,313,L162,313	RAAS	Endocrinology/Hormones
	L-162,313是一种ANG II受体激动剂，是一种模仿血管紧张素II生物学作用的非肽，可诱导MAP增加。
T40220L	TRV055 acetate TRV055 acetate (25849-90-5 Free base)	RAAS	Endocrinology/Hormones
	TRV055 acetate 是血管紧张素 II 1 型受体的配体，可刺激细胞 Gq 介导的信号传导。
T7577	Angiotensin III, human, mouse 血管紧张素III,Angiotensin III, human, mouse(3TFA)	RAAS	Endocrinology/Hormones
	Angiotensin III, human, mouse (Angiotensin III, human, mouse(3TFA)) 是一种七肽，是血管紧张素 2 型受体 (AT2R) 激动剂，能够作用于 AT2R (IC50:0.648 nM)及 AT1R (IC50:21.1nM)。
T0215L	Losartan DuP-753,氯沙坦,洛沙坦	RAAS	Endocrinology/Hormones
	Losartan (DuP-753) 是一种血管紧张素II 受体拮抗剂，能够与血管紧张素II 竞争性结合AT1受体(IC50:20 nM)。
T7663L	Angiotensin 1/2 (1-9) TFA Angiotensin 1/2 (1-9) TFA (34273-12-6 free base）	Others	Others
	Angiotensin 1/2 (1-9) TFA(34273-12-6(free base)) 含有从血管紧张素 I/II 肽转化而来的氨基酸 1-9。
T6067	PD 123319 (S)-(+)-PD 123319,PD123319	RAAS	Endocrinology/Hormones
	PD 123319 ((S)-(+)-PD 123319) 是一种血管紧张素 II 受体拮抗剂(IC50:34 nM)。
T1518	Olmesartan Medoxomil 奥美沙坦酯,CS 866,Benicar	RAAS	Endocrinology/Hormones
	Olmesartan Medoxomil (Benicar) 是血管紧张素 (angiotensin AT1) 受体选择性抑制剂(IC50:66.2 μM)。
T7797	Tasosartan 他索沙坦,WAY-ANA 756	RAAS	Endocrinology/Hormones
	Tasosartan (WAY-ANA 756) 是长效血管紧张素 II 受体拮抗剂。
T14337	Buloxibutid AT2 receptor agonist C21	RAAS	Endocrinology/Hormones
	Buloxibutid (AT2 receptor agonist C21) 是一种新型且具有选择性小分子 angiotensin II AT2 receptor (血管紧张素 II AT2 受体)激动剂，对 AT2 受体和 AT1 受体的 Ki 值分别为 0.4 nM 和 10 μM。
T3281	Delapril hydrochloride indalapril,地拉普利盐酸盐,Alindapril Hydrochloride,Delapril Hydrochloride,盐酸地拉普利,CV 3317	RAAS	Endocrinology/Hormones
	Delapril hydrochloride (indalapril) 是一种血管紧张素转化酶抑制剂，能够用于心血管疾病的研究。
T67848	Valsartan Methyl Ester	RAAS	Endocrinology/Hormones
	Valsartan Methyl Ester 是一种强效血管紧张素II 受体拮抗剂，IC50=0.06uM。
T65740	Trityl candesartan	Others	Others
	Trityl candesartan 是用于合成血管紧张素 II 受体拮抗剂 Candesartan 和 Candesartan cilexetil 的重要中间体。
T6716	Valsartan Diovan,缬沙坦,Tareg,CGP 48933	RAAS	Endocrinology/Hormones
	Valsartan (CGP 48933) 是一种血管紧张素 II 受体拮抗剂，有用于高血压和心力衰竭的研究潜力。
T2531L	Eprosartan KF-108566J free base,Teveten	RAAS	Endocrinology/Hormones
	Eprosartan (SKF-108566J free base) 是一种具有选择性和竞争性的非肽类血管紧张素II受体拮抗剂，对AT1受体亚型具有高亲和力，可用作降压剂。Eprosartan 对血管紧张素 II 受体有抑制作用，在大鼠和人类肾上腺皮质膜中的 IC50 值分别为 9.2 nM 和 3.9 nM。
T5964	Olmesartan CS 088,奥美沙坦,RNH 6270	RAAS	Endocrinology/Hormones
	Olmesartan (RNH 6270) 是一种血管紧张素 II 受体 (AT1R) 拮抗剂，常用于研究高血压。
TP1295	Angiotensin I (human, mouse, rat) Angiotensin 1 Human,血管紧张素 1 (人)	Others	Others
	Angiotensin I (human, mouse, rat) 是血管紧张素Ⅱ的前体物质，在血管紧张素转化酶 (ACE) 的参与下裂解成血管紧张素Ⅱ。

化合物

Angiotensin I/II (1-5)

Cat.No: TP1528

Synonym: Angiotensin I/II 1-5

Target: RAAS, Others

(Sar¹)-Angiotensin II acetate

Cat.No: T35834L

Target: RAAS

Angiotensin I/II (1-6)

Cat.No: TP1579

Synonym: Angiotensin I/II 1-6

Target: RAAS, Others

Angiotensin II 5-valine TFA

Cat.No: TP1017L

Synonym: Angiotensin II 5-valine TFA(58-49-1 free base)

Target: RAAS

[Sar1, Ile8]-Angiotensin II 3TFA

Cat.No: T7575L

Synonym: [Sar1, Ile8]-Angiotensin II 3TFA(37827-06-8(free base))

Target: Others

[Sar1, Ile8]-Angiotensin II acetate

Cat.No: T7575L1

Target: RAAS

Angiotensin II human acetate

Cat.No: T8560

Synonym: Ang II acetate,DRVYIHPF acetate,Angiotensin II acetate,血管紧张素II

Target: Apoptosis, RAAS

(Sar1)-Angiotensin II

Cat.No: T35834

Synonym: (Sar¹)-Angiotensin II

[Tyr(P)4] Angiotensin II

Cat.No: T38697

[Sar1, Ile8]-Angiotensin II

Cat.No: T7575

Synonym: [Sar1, Ile8]-Angiotensin II(3TFA)

Target: RAAS, Others

Angiotensin I/II (1-6) (TFA)

Cat.No: T36622

Angiotensin II (3-8), human

Cat.No: T5824

Synonym: Angiotensin IV

Target: RAAS

Angiotensin II 5-valine

Cat.No: TP1017

Synonym: Valine angiotensin II,5-L-Valine angiotensin II,血管紧张素 Ⅱ 5-缬氨酸

Angiotensin II (5-8), human

Cat.No: TP1522

Angiotensin II (1-4), human

Cat.No: TP1609

[Sar1, Ile8]-Angiotensin II TFA

Cat.No: TP1224

Synonym: Angiotensin 2 TFA,AngiotensinII TFA

Pentasarcosyl angiotensin II

Cat.No: TP2464

Synonym: (Sar)5 aii

Angiotensin II (3-8), human TFA

Cat.No: T10323

Target: RAAS

Angiotensin II (1-4), human TFA

Cat.No: TP1661

Saralasin acetate(34273-10-4 free base)

Cat.No: TP1929L1

Target: RAAS

Eprosartan Mesylate

Cat.No: T2531

Synonym: SKF-108566J,甲磺酸依普罗沙坦

Target: RAAS

Angiotensin pentapeptide

Cat.No: TP2370

Synonym: Angiotensin II (4-8),(Des-1,2,3)angiotensin II

Enalaprilat Dihydrate

Cat.No: T6340

Synonym: 依那普利拉二水合物,MK-422,MK-422 Dihydrate

Target: RAAS, Autophagy

Cat.No: T1461

Synonym: CV 11974,坎地沙坦

Target: RAAS

Losartan Carboxylic Acid

Cat.No: T3461

Synonym: EXP-3174,E-3174

Target: RAAS

Angiotensin II human TFA

Cat.No: T74142

(Sar1,Ile4,8)-Angiotensin II

Cat.No: T76634

Moexipril hydrochloride

Cat.No: T6595

Synonym: 莫昔普利盐酸盐,Moexipril HCl,RS-10085,SPM 925,CI-925

Target: Apoptosis, RAAS

Cat.No: T1615

Synonym: 厄贝沙坦,SR-47436,BMS-186295

Target: Apoptosis, RAAS

Candesartan Cilexetil

Cat.No: T2400

Synonym: TCV-116,坎地沙坦酯,坎地沙坦西酯

Target: Apoptosis, RAAS

Cat.No: T28540

Synonym: UP 269-6,UP-2696,UP 2696,UP-269-6,UP269-6

Target: RAAS

Perindopril erbumine

Cat.No: T1484L

Synonym: 培哚普利叔丁胺,培哚普利叔丁胺盐,S9490-3,Perindopril tert-butylamine salt

Target: Apoptosis, RAAS, MRP

ZD 7155 hydrochloride

Cat.No: T13390

Target: RAAS

Losartan potassium

Cat.No: T0215

Synonym: DuP-753 potassium,洛沙坦钾,氯沙坦钾,MK 954,DuP 753

Target: RAAS

Cat.No: T27762

Synonym: L-162313,L 162,313,L162,313

Target: RAAS

Cat.No: T40220L

Synonym: TRV055 acetate (25849-90-5 Free base)

Target: RAAS

Angiotensin III, human, mouse

Cat.No: T7577

Synonym: 血管紧张素III,Angiotensin III, human, mouse(3TFA)

Target: RAAS

Cat.No: T0215L

Synonym: DuP-753,氯沙坦,洛沙坦

Target: RAAS

Angiotensin 1/2 (1-9) TFA

Cat.No: T7663L

Synonym: Angiotensin 1/2 (1-9) TFA (34273-12-6 free base）

Target: Others

Cat.No: T6067

Synonym: (S)-(+)-PD 123319,PD123319

Target: RAAS

Olmesartan Medoxomil

Cat.No: T1518

Synonym: 奥美沙坦酯,CS 866,Benicar

Target: RAAS

Cat.No: T7797

Synonym: 他索沙坦,WAY-ANA 756

Target: RAAS

Cat.No: T14337

Synonym: AT2 receptor agonist C21

Target: RAAS

Delapril hydrochloride

Cat.No: T3281

Synonym: indalapril,地拉普利盐酸盐,Alindapril Hydrochloride,Delapril Hydrochloride,盐酸地拉普利,CV 3317

Target: RAAS

Valsartan Methyl Ester

Cat.No: T67848

Target: RAAS

Trityl candesartan

Cat.No: T65740

Target: Others

Cat.No: T6716

Synonym: Diovan,缬沙坦,Tareg,CGP 48933

Target: RAAS

Cat.No: T2531L

Synonym: KF-108566J free base,Teveten

Target: RAAS

Cat.No: T5964

Synonym: CS 088,奥美沙坦,RNH 6270

Target: RAAS

Angiotensin I (human, mouse, rat)

Cat.No: TP1295

Synonym: Angiotensin 1 Human,血管紧张素 1 (人)

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T7040	Angiotensin II human DRVYIHPF,Angiotensin II,Hypertensin II,血管紧张素Ⅱ,Ang II,血管紧张素II	Apoptosis; RAAS	Apoptosis; Endocrinology/Hormones
	Angiotensin II human (Ang II) 是一种生物活性肽，一种血管收缩剂。Angiotensin II 可以与 AT1R 和 AT2R 相互作用，调节人类血压，刺激交感神经，增加醛固酮生物合成和肾脏活动。
TN7109	Prosaikogenin G	RAAS	Endocrinology/Hormones
	Prosaikogenin G 是一种从柴胡的根中分离出的化合物，是 Saikosaponin d 在胃肠道中的衍生物。Prosaikogenin G 对 Angiotensin II 诱导的大鼠系膜细胞增殖具有明显的抑制作用，同时对肾脏有保护作用。
T8270	Deserpidine 地舍平,Harmonyl	RAAS	Endocrinology/Hormones
	Deserpidine (Harmonyl) 是从 Rauwolfia canescens 的根中分离的生物碱。Deserpidine 与 Reserpine 相关。Deserpidine 是竞争性血管紧张素转化酶抑制剂，可以被用作抗高血压药以及镇定剂。Deserpidine 还减少了肾上腺皮质血管紧张素 II 诱导的醛固酮分泌。
T2836	Isorhamnetin 3-methylquercetin,3'-Methylquercetin,Isorhamnetol,异鼠李素,3'-Methoxyquercetin	MEK; PI3K; Endogenous Metabolite	MAPK; Metabolism; PI3K/Akt/mTOR signaling
	Isorhamnetin (3-methylquercetin) 是从中草药沙棘中提取的一种类黄酮，可通过抑制MEK1和PI3K 来抑制皮肤癌。
T37298	Spinacine	Endogenous Metabolite	Metabolism
	Spinacine 是人内源性代谢产物。
T38593	1-Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone	Others	Others
	Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9, a quinolone alkaloid derived from Evodia rutaecarpa, is a potent antagonist of the angiotensin II receptor, displaying an IC50 value of 48.2 μM.
T81229	Safflor yellow B
	Safflor yellow B 通过抑制血管紧张素 II 介导的人脐静脉细胞损伤，调节 Bcl-2/p22 (phox) 表达，展现出神经保护作用。
T75697	1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone	Others	Others
	1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone，为喹诺酮类生物碱，作用为二酰基甘油酰基转移酶抑制剂与血管紧张素II受体阻断剂，其IC50值依次为20.1 μM与34.1 μM。此化合物亦展现对幽门螺杆菌的有效抗活性，MIC值达10 μg/mL。

天然产物

Angiotensin II human

Cat.No: T7040

Synonym: DRVYIHPF,Angiotensin II,Hypertensin II,血管紧张素Ⅱ,Ang II,血管紧张素II

Target: Apoptosis, RAAS

Prosaikogenin G

Cat.No: TN7109

Target: RAAS

Cat.No: T8270

Synonym: 地舍平,Harmonyl

Target: RAAS

Cat.No: T2836

Synonym: 3-methylquercetin,3'-Methylquercetin,Isorhamnetol,异鼠李素,3'-Methoxyquercetin

Target: MEK, PI3K, Endogenous Metabolite

Cat.No: T37298

Target: Endogenous Metabolite

1-Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone

Cat.No: T38593

Target: Others

Safflor yellow B

Cat.No: T81229

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone

Cat.No: T75697

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02268	AGTR2 Protein, Human, Recombinant (His & SUMO) AT2 receptor,Angiotensin II type-2 recepto...	Human	E. coli
	Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.
TMPH-02267	AGTRAP Protein, Human, Recombinant (His & Myc & SUMO) ATRAP,AT1 receptor-associated protein,Type-1 angiotensin...	Human	E. coli
	Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.
TMPK-00383	ACE2/ACEH Protein, Human, Recombinant (His & Avi) ACE2,ACE-2,ACEH	Human	HEK293 Cells
	ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension.The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. A...
TMPJ-00386	ACE2/ACEH Protein, Human, Recombinant (HEK293, His & Avi), Biotinylated Metalloprotease MPROT15,ACEH,Angiotensin-Converting...	Human	HEK293 Cells
	Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate...
TMPK-00552	ACE2/ACEH Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated ACEH,ACE-2,ACE2	Cynomolgus	HEK293 Cells
	ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension.The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. A...
TMPK-00551	ACE2/ACEH Protein, Cynomolgus, Recombinant (His & Avi) ACE-2,ACEH,ACE2	Cynomolgus	HEK293 Cells
	ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension.The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. A...
TMPK-00382	ACE2/ACEH Protein, Human, Recombinant (hFc & Avi), Biotinylated ACE-2,ACE2,ACEH	Human	HEK293 Cells
	ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension.The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. A...
TMPY-02574	Chymase 1 Protein, Human, Recombinant (His) MCT1,chymase 1, mast cell,chymase,CYH	Human	Baculovirus Insect Cells
	The STR polymorphism in the CMA1 gene is associated with asthma and that this association is even stronger with atopic asthma. CMA1 and IL-4 in atopic asthma and for IL-4 in atopy in general. The local angiotensin II system (LAS) has numerous functions, including the regulation of growth and differentiation in the gastrointestinal tract. Angiotensin II (AngII) may be generated by angiotensin-I-converting enzyme (ACE) or mast cell chymase (CMA1) and plays an important role in inflammatory process...
TMPH-01041	Carboxypeptidase A6 Protein, Human, Recombinant (His & SUMO) CPAH,CPA6,Carboxypeptidase A6	Human	E. coli
	May be involved in the proteolytic inactivation of enkephalins and neurotensin in some brain areas. May convert inactive angiotensin I into the biologically active angiotensin II. Releases a C-terminal amino acid, with preference for large hydrophobic C-terminal amino acids and shows only very weak activity toward small amino acids and histidine. Carboxypeptidase A6 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular w...
TMPJ-00964	PRCP Protein, Human, Recombinant (His) PCP,Proline Carboxypeptidase,PRCP,Lysosomal Pro-X Carboxypep...	Human	HEK293 Cells
	Lysosomal Pro-X Carboxypeptidase (PRCP) belongs to the peptidase S28 family. PRCP is detected in many tissues, with highest levels observed in placenta, lung, and liver. It is also present in the heart, brain, pancreas, and kidney. PRCP exists as a homodimer. PRCP cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH. PRCP has been s...
TMPY-01027	Mast Cell Protease-1/MCPT-1 Protein, Mouse, Recombinant (His) carnitine palmitoyltransferase 1B (muscle),AV080368,Mcp-1	Mouse	HEK293 Cells
	Mast Cell Protease 1 (MMCP-1), also known as MCP-1, MCPT-1 and β-chymase, is a member of the Chymase family of chymotrypsin-like serine proteases. MCPT-1 is a 26 kDa β-chymase that is a component of mast cell granules. It is a 226 amino acid (aa) protein that has a conserved pattern of six cysteines and one potential glycosylation site. The granule-derived mouse mast cell proteases-1 and -2 (mMCP-1 and -2) colocalize in similar quantities in mucosal mast cells but micrograms of mMCP-1 compared w...
TMPH-02274	JAK2 Protein, Human, Recombinant (His) JAK2,Janus kinase 2,Tyrosine-protein kinase JAK2	Human	E. coli
	Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple int...

重组蛋白

AGTR2 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02268

Species: Human

Expression System: E. coli

AGTRAP Protein, Human, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-02267

Species: Human

Expression System: E. coli

ACE2/ACEH Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00383

Species: Human

Expression System: HEK293 Cells

ACE2/ACEH Protein, Human, Recombinant (HEK293, His & Avi), Biotinylated

Cat.No: TMPJ-00386

Species: Human

Expression System: HEK293 Cells

ACE2/ACEH Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00552

Species: Cynomolgus

Expression System: HEK293 Cells

ACE2/ACEH Protein, Cynomolgus, Recombinant (His & Avi)

Cat.No: TMPK-00551

Species: Cynomolgus

Expression System: HEK293 Cells

ACE2/ACEH Protein, Human, Recombinant (hFc & Avi), Biotinylated

Cat.No: TMPK-00382

Species: Human

Expression System: HEK293 Cells

Chymase 1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02574

Species: Human

Expression System: Baculovirus Insect Cells

Carboxypeptidase A6 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01041

Species: Human

Expression System: E. coli

PRCP Protein, Human, Recombinant (His)

Cat.No: TMPJ-00964

Species: Human

Expression System: HEK293 Cells

Mast Cell Protease-1/MCPT-1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01027

Species: Mouse

Expression System: HEK293 Cells

JAK2 Protein, Human, Recombinant (His)

Cat.No: TMPH-02274

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T11870	Losartan D4 氯沙坦 D4,DuP-753 D4	Others	Others
	Losartan D4, the deuterium-labeled version of Losartan, functions as an angiotensin II receptor antagonist. It inhibits the interaction between angiotensin II and AT1 receptors by competing for binding, achieving an IC50 value of 20 nM.
T11675	Irbesartan-d4 厄贝沙坦 D4,SR-47436 D4,BMS-186295 D4	Others	Others
	Irbesartan D4, a deuterium-labeled variant of Irbesartan, is a highly potent and specific antagonist of the angiotensin II type 1 (AT1) receptor.
T11869	Losartan (D4 Carboxylic Acid) E-3174 D4,氯沙坦羧酸 D4,EXP-3174 D4	Others	Others
	Losartan D4 Carboxylic Acid is the deuterium labeled Losartan, which is an angiotensin II receptor antagonist.
T10440	Azilsartan-d5 TAK-536 D5	Others	Others
	Azilsartan (TAK-536) D5 is the deuterium-labeled Azilsartan. Azilsartan is a specific antagonist of the angiotensin II type 1 receptor.
T10670	Candesartan-d4 坎地沙坦 D4,CV-11974 D4	Others	Others
	Candesartan D4 is the deuterium labeled Candesartan. Candesartan is an antagonist of angiotensin II receptor.
T12300	Olmesartan-d4 RNH-6270 D4,奥美沙坦 D4	Others	Others
	Olmesartan D4 is the deuterium labeled Olmesartan. Olmesartan is an antagonist of angiotensin II receptor (AT1R) used to treat high blood pressure.
T13282	Valsartan-d9 CGP-48933 D9,缬沙坦 D9	Others	Others
	Valsartan D9 is a deuterium-labeled valsartan. Valsartan is an antagonist of the angiotensin II receptor and for the treatment of high blood pressure and heart failure.
TMIJ-0131	rac-Valsartan-d9
	rac-Valsartan-d9 是 rac-Valsartan 的氘代化合物。rac-Valsartan 的 CAS 号为 137862-53-4。Valsarta 是一种血管紧张素 II 受体拮抗剂，有用于高血压和心力衰竭的研究潜力。
TMID-0241	Olmesartan-d6 Acid
	Olmesartan-d6 Acid 是 Olmesartan Acid 的氘代化合物。Olmesartan Acid 的 CAS 号为 144689-24-7。Olmesartan 是一种血管紧张素II受体 (AT1R) 拮抗剂，常用于研究高血压。
TMIJ-0185	Telmisartan-13C-d3
	Telmisartan-13C-d3 是 Telmisartan 的 13C 和氘代化合物。Telmisartan 的 CAS 号为 144701-48-4。Telmisartan 是一种血管紧张素II 1型受体拮抗剂，能够抑制其活性，IC50值为 9.2 nM。
TMIJ-0317	Nadolol-d9 (Mixture of Diastereomers)
	Nadolol-d9 (Mixture of Diastereomers) 是 Nadolol 的氘代化合物。Nadolol 的 CAS 号为 42200-33-9。Nadolol 是一种有机阴离子转运多肽 1A2 (OATP1A2) 的底物，是一种非选择性的、具有口服活性的 β-肾上腺素受体 (β-adrenergic receptors) 阻滞剂，可用于高血压，心绞痛和血管性头痛的研究。

同位素标记化合物

Cat.No: T11870

Synonym: 氯沙坦 D4,DuP-753 D4

Target: Others

Cat.No: T11675

Synonym: 厄贝沙坦 D4,SR-47436 D4,BMS-186295 D4

Target: Others

Losartan (D4 Carboxylic Acid)

Cat.No: T11869

Synonym: E-3174 D4,氯沙坦羧酸 D4,EXP-3174 D4

Target: Others

Cat.No: T10440

Synonym: TAK-536 D5

Target: Others

Cat.No: T10670

Synonym: 坎地沙坦 D4,CV-11974 D4

Target: Others

Cat.No: T12300

Synonym: RNH-6270 D4,奥美沙坦 D4

Target: Others

Cat.No: T13282

Synonym: CGP-48933 D9,缬沙坦 D9

Target: Others

rac-Valsartan-d9

Cat.No: TMIJ-0131

Olmesartan-d6 Acid

Cat.No: TMID-0241

Telmisartan-13C-d3

Cat.No: TMIJ-0185

Nadolol-d9 (Mixture of Diastereomers)

Cat.No: TMIJ-0317

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