186
48
7
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8239 |
Cromoglicic acid
|
Others | Others |
Cromoglicic acid 可防止肥大细胞释放炎性化学物质,例如组胺。 | |||
T82424 |
Experimental allergic encephalitogenic peptide (human)
|
||
Experimental allergic encephalitogenic peptide (human) 为EAE多肽类化合物,能够诱导豚鼠发生脑脊髓炎。 | |||
T15598 |
Isosulfan blue
|
Others | Others |
Isosulfan blue 是用于淋巴管造影中淋巴管识别的蓝色染料,可用于乳腺癌前哨淋巴结活检,但其在乳腺癌手术中有发生过敏反应的可能性。 | |||
T5424 |
Etosalamide
依托柳胺,Ethosalamide |
Others | Others |
Etosalamide (Ethosalamide) 是一种解热缓解疼痛的试剂。它具有抗炎作用,可用于研究过敏性疾病。 | |||
T9926 |
Omalizumab
|
Others | Others |
Omalizumab 是针对人免疫球蛋白 E 的重组人源化单克隆抗体(KD:0.393 nM)。它能够结合人 FcγRIIb 受体(KD:6.37 uM)。它对持续性过敏性哮喘具有潜在的研究价值。 | |||
T4563 |
Thonzylamine
neohetramine,松齐拉敏 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Thonzylamine (neohetramine) 是可口服的H1组胺受体拮抗剂,具有抗组胺和抗过敏特性,可用于鼻充血、过敏性结膜炎和其他过敏性疾病的研究。 | |||
T5449 |
Bamaquimast
L 0042,F 10126 |
Proton pump | Membrane transporter/Ion channel |
Bamaquimast (L 0042) 是一种 proton pump 抑制剂,可用于研究哮喘类的免疫系统疾病和呼吸系统疾病。 | |||
T3979 |
Emedastine
LY188695,依美斯汀,Emadine |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Emedastine (LY188695) 是一种可口服的,选择性和高亲和力的组胺 H1受体拮抗剂,Ki 值为 1.3 nM。它是苯并咪唑衍生物,可用于过敏性鼻炎、过敏性皮肤疾病和过敏性结膜炎的研究。 | |||
T9043 |
AS1810722
|
P450; STAT | JAK/STAT signaling; Metabolism; Stem Cells |
AS1810722 是口服有效的STAT6抑制剂,IC50为 1.9 nM。它是一种稠合双环嘧啶衍生物,对有良好的CYP3A4抑制作用,具有用于过敏性疾病,如哮喘和特应性疾病的研究潜力。 | |||
T7860 |
SM-324405
SM 324405 |
TLR | Immunology/Inflammation |
SM-324405 是TLR7的激动剂,EC50 为 50 nM,对人和大鼠 TLR7 的 pEC50值分别为 7.3 和 6.6,可用于过敏性疾病的免疫治疗研究。 | |||
T4348 |
Syk Inhibitor II
|
5-HT Receptor; Syk | Angiogenesis; GPCR/G Protein; Neuroscience; Tyrosine Kinase/Adaptors |
Syk Inhibitor II 是一种可渗透细胞、具有 ATP 竞争性的嘧啶-甲酰胺化合物,可选择性且可逆地抑制 Syk,IC50为 41 nM。 | |||
T0211 |
Azelastine
Azelastina,Astelin,Azelastinum,氮卓斯汀 |
SARS-CoV; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience |
Azelastine (Azelastinum) 是一种选择性组胺 1 拮抗剂,可研究过敏性鼻炎、哮喘、糖尿病高脂血症和 SARS-CoV-2 。 | |||
T0118 |
Mizolastine
SL 850324,咪唑司汀,咪唑斯汀 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Mizolastine (SL 850324) 是组胺 H1 受体拮抗剂,IC50为 47 nM。它用于治疗过敏反应,如花粉热和荨麻疹等。 | |||
T5310 |
TR-14035
MDK-1191 |
Integrin | Cytoskeletal Signaling |
TR-14035 (MDK-1191) 是一种具有口服活性的 α4β7/α4β1整合素双重抑制剂,对 α4β7和 α4β1作用的 IC50值分别为 7 和 87 nM,可用于炎症和自体免疫疾病的研究。 | |||
T6242 |
Rupatadine Fumarate
富马酸卢帕他定,Rinialer,Rupafin,Alergoliber |
PAFR; Autophagy; Histamine Receptor | Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Rupatadine Fumarate (Rinialer) 是一种可口服的长效PAF/H1受体的双抑制剂,Ki 值分别为 0.55 μM 和 0.1 μM。它可研究过敏性鼻炎和荨麻疹。 | |||
T3185 |
R112
(E)-Elafibranor |
Syk | Angiogenesis; Tyrosine Kinase/Adaptors |
R112 ((E)-Elafibranor) 是ATP 竞争性的 Syk 激酶抑制剂,它能够抑制Syk 激酶活性,Ki=6 nM,IC50=226 nM。 | |||
T0059 |
Diphenylpyraline hydrochloride
盐酸双苯比拉林,4-Diphenylmethoxy-1-methylpiperidine hydrochloride |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Diphenylpyraline hydrochloride (4-Diphenylmethoxy-1-methylpiperidine hydrochloride) 是一种组胺 H1 受体的拮抗剂,抑制多巴胺的吸收。它是可口服的抗组胺试剂,具有抗胆碱和抗过敏作用,可用于缓解过敏性疾病,如鼻炎、花粉热和瘙痒性皮肤疾病等。 | |||
T21404 |
Fluticasone furoate
Veramyst,Allermist,Avamys,糠酸氟替卡松,Fluticasone furoate |
Glucocorticoid Receptor | Endocrinology/Hormones |
Fluticasone furoate (Avamys) 是一种合成的三氟化皮质类固醇,衍生自氟替卡松,Kd 为 0.3 nM。Fluticasone furoate 具有有效的抗炎、抗哮喘活性和低全身暴露。Fluticasone furoate 可用作过敏性鼻炎治疗研究的鼻喷雾剂。 | |||
T0211L |
Azelastine hydrochloride
Optivar,Azelastine HCl,Allergodil,盐酸氮卓斯汀,Astelin |
SARS-CoV; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience |
Azelastine hydrochloride (Astelin) 是一种选择性组胺 1拮抗剂,可研究过敏性鼻炎、哮喘、糖尿病高脂血症和 SARS-CoV-2 。 | |||
T1030 |
Triprolidine hydrochloride monohydrate
盐酸曲普利啶,盐酸曲普利啶一水合物,Triprolidine hydrochloride |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Triprolidine hydrochloride monohydrate 是一种组胺 H1 拮抗剂,用于过敏性鼻炎、哮喘。 | |||
T12412L |
PDK4-IN-1 hydrochloride
|
Apoptosis; PDK | Apoptosis; PI3K/Akt/mTOR signaling |
PDK4-IN-1 hydrochloride 是一种蒽醌衍生物,对丙酮酸脱氢酶激酶 4有抑制作用,IC50为 84 nM,具有口服活性。它抑制细胞转化和细胞增殖并诱导细胞凋亡。它具有抗过敏,抗糖尿病和抗癌作用。 | |||
T21412 |
Ketorolac
Toradol,Sprix,Acuvail,Macril,酮咯酸,Acular |
COX | Immunology/Inflammation; Neuroscience |
Ketorolac (Acuvail) 是非甾体抗炎剂,是非选择性的COX 抑制剂,对 COX-1 和 COX-2 的IC50值分别为 20 和 120 nM。 | |||
T1269 |
Tripelennamine hydrochloride
Pyribenzamine hydrochloride,去敏灵,Tripelennamine HCl,Pyribenzamine HCl,盐酸曲吡那敏 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Tripelennamine hydrochloride (Pyribenzamine hydrochloride) 是一种组胺 H1 拮抗剂,具有低镇静作用,但经常刺激胃肠道。 | |||
T2335 |
Ebastine
Ebastel,依巴斯汀,LAS-W 090,Ebastin,Kestine,RP64305 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Ebastine (Kestine) 是一种可口服的组胺 H1 受体拮抗剂,用于过敏性鼻炎的症状和慢性特发性荨麻疹的研究。 | |||
T0147 |
Clemastine fumarate
HS-592 (fumarate),富马酸氯马斯汀,Meclastine fumarate,Meclastine (fumarate) |
Autophagy; Histamine Receptor | Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Clemastine fumarate (Meclastine (fumarate)) 是一种合成乙醇胺,具有抗胆碱能、镇静和组胺 H1 拮抗作用。 | |||
T0188 |
Fluticasone (propionate)
丙酸氟替卡松,CCI-187881,氟替卡松丙酸酯,Fluticasone propionate |
Glucocorticoid Receptor; Virus Protease; Estrogen/progestogen Receptor; Phospholipase; Endogenous Metabolite; ADC Cytotoxin | Antibody-drug Conjugate/ADC Related; Endocrinology/Hormones; Metabolism; Microbiology/Virology |
Fluticasone propionate (CCI-187881) 是一种选择性糖皮质激素受体激动剂,是一种局部抗炎激素,亲和力KD 为 0.5 nM。具有抗病毒活性。 | |||
T0089 |
Cetirizine dihydrochloride
盐酸西替利嗪,P071,UCB P071,Cetirizine DiHCl |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Cetirizine dihydrochloride (UCB P071) 是羟嗪的羧化代谢物,是特异性口服有效的 H1 受体长效拮抗剂。它标记抗过敏特性,抑制过敏反应期间嗜酸性粒细胞趋化,可有效治疗过敏性鼻炎、确诊荨麻疹和花粉诱发的哮喘。 | |||
T0205 |
Brompheniramine maleate
Dimotane,马来酸溴苯那敏,Rolabromophen,Brompheniramine hydrogen maleate,Dimetane |
5-HT Receptor; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Brompheniramine maleate (Dimotane) 是一种可口服的丙胺类抗组胺剂,具有抗胆碱能和抗抑郁作用,可用于过敏性鼻炎和缓解疼痛的研究。它是一种选择性组胺 H1 受体拮抗剂,Kd 为 6.06 nM。 | |||
T63825 |
Antiallergic agent-1
|
Others | Others |
Antiallergic agent-1 是 Src 家族激酶抑制剂,是一种新的有价值的先导化合物,具有作为抗过敏剂的潜力。 | |||
T15772 |
Lodoxamide tromethamine
U-42585E |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Lodoxamide tromethamine 是一种的肥大细胞稳定剂,具有抗过敏特性,可用于治疗哮喘和过敏性结膜炎的研究。 | |||
T0113 |
Mebhydrolin napadisylate
Incidal,Diazolin,Mebhydroline 1,5-naphthalenedisulfonate salt,美海屈林萘二磺酸盐,Omeril,Diazoline |
5-HT Receptor; AChR; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Mebhydrolin napadisylate (Incidal) 是一种抗组胺药,用于缓解组胺释放引起的过敏症状,如鼻过敏和过敏性皮肤病。 | |||
T7812 |
Acitazanolast
MTCC,阿扎司特,WP-871 |
Others | Others |
Acitazanolast (WP-871) 是一种抗过敏候选药物。 | |||
T15666 |
KP136
AL136 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
KP136 (AL136) 是一种具有口服活性的抗过敏化合物,抑制组胺释放,可用于研究哮喘和过敏性水肿。 | |||
T68150 |
Talastine
|
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Talastine 是一种抗组胺化合物,可诱发过敏性皮疹。 | |||
T68094 |
Lodoxamide ethyl
|
Others | Others |
lodoxamide ethyl 是一种新的口服活性抗过敏化合物,可用于预防抗原诱导的支气管收缩和阻断皮肤过敏反应。 | |||
T27159 |
DF-1111301
DF1111301,DF 1111301 |
Platelet aggregation; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience; Others |
DF-1111301 是一种具有抗组胺 H1和抗PAF活性的新型抗过敏化合物。 | |||
T1278 |
Astemizole
Laridal,Histaminos,Paralergin,阿司咪唑 |
Potassium Channel; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience |
Astemizole (Laridal) 是一种长效、非镇静抗组胺药,用于治疗季节性过敏性鼻炎、哮喘、过敏性结膜炎和慢性特发性荨麻疹。它是组胺 H1 受体的拮抗剂,IC50值为 4 nM,还阻断 hERG K+通道,IC50值为 0.9 nM,具有抗胆碱能和止痒作用。 | |||
T1170 |
Olopatadine hydrochloride
盐酸奥洛他定,Olopatadine HCl,KW4679,ALO4943A |
5-HT Receptor; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Olopatadine hydrochloride (ALO4943A) 是一种抗组胺药,具有稳定肥大细胞的特性,用作治疗过敏性结膜炎的滴眼液。 | |||
T21060L |
NPC 567 acetate
NPC 567 acetate(109333-26-8 Free base) |
Bradykinin Receptor | GPCR/G Protein |
NPC 567 acetate 是一种缓激肽 B2 拮抗剂,可用于治疗过敏性气道疾病的研究。 | |||
T1553 |
Chlorpheniramine maleate
马来酸氯苯那敏,NCI-C55265,Chlorphenamine maleate |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Chlorpheniramine maleate (NCI-C55265) 是一种组胺 H1 拮抗剂,IC50为12 nM,用于过敏反应、花粉热、鼻炎、荨麻疹和哮喘。 | |||
T21361 |
Alclometasone dipropionate
Vaderm,Sch 22219,Aclovate,Delonal |
Others | Others |
Alclometasone dipropionate (Sch 22219) 是一种人工合成的糖皮质激素,属于类固醇化合物,具有抗增生、抗炎、抗过敏、止痒和收缩血管的作用,可用于研究皮肤炎症。 | |||
T2392 |
Nafamostat mesylate
甲磺酸萘莫司他,FUT-175 |
Apoptosis; Serine/threonin kinase; SARS-CoV; Serine Protease | Apoptosis; Cell Cycle/Checkpoint; Metabolism; Microbiology/Virology; Proteases/Proteasome |
Nafamostat mesylate (FUT-175) 是一种广谱丝氨酸蛋白酶抑制剂,血管舒缓素抑制剂,能抑制血液凝固。它通过降低颗粒酶活性和 CTL 细胞溶解抑制T 细胞自身反应活性,可抑制SARS-CoV-2 的激活。它还是潜在的补体抑制剂。 | |||
T1531 |
Mometasone furoate
糠酸莫美他松,糠酸莫米松,Sch32088 |
Glucocorticoid Receptor | Endocrinology/Hormones |
Mometasone furoate (Sch32088) 是糖皮质激素受体激动剂,具有抗炎和抗过敏作用。它是皮质固醇类试剂,动物模型中,可局部应用于气道炎症、慢性皮肤湿疹、哮喘。 | |||
T69730 |
F092
|
PGE Synthase | Immunology/Inflammation |
F092 是一种高效的造血前列腺素 D 合成酶 (H-PGDS) 抑制剂, 可以用于研究过敏性炎症和与血管相关的疾病。 | |||
T68128 |
Picumast
|
Others | Others |
Picumast 是一种具有抗过敏活性,可被用于治疗哮喘,可能用于治疗治疗过敏性气道疾病。 | |||
T10945 |
D18024
|
Others | Others |
D18024 是一种酞嗪酮的衍生物,显示出抗过敏和抗组胺活性。 | |||
T2270 |
Trans-Tranilast
Tranilast trans-,反式-曲尼司特,反-曲尼司特 |
RAAS | Endocrinology/Hormones |
Trans-Tranilast 是抗过敏剂,可用于过敏性鼻炎、支气管哮喘和特应性皮炎的研究。 | |||
T0298 |
Dimenhydrinate
茶苯海明,Dramamine,Chloranautine,乘晕宁,Vomex A |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Dimenhydrinate (Vomex A) 是一种乙醇胺和组胺拮抗剂,具有抗过敏活性,可作为抗催吐剂。 | |||
T27244 |
Efletirizine
UCB 28754,UCB-28754,UCB28754 |
Lipoxygenase; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience |
Efletirizine (UCB-28754) 是一种组胺受体拮抗剂,对5-脂氧合酶(5-LO)具有抑制作用,对可用于局部治疗过敏疾病。 | |||
T6660 |
SB-705498
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
SB705498 是一种口服有效的 TRPV1选择性拮抗剂,pIC50值为 7.1。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4S0398 |
Rosin
松香树脂 |
p38 MAPK | MAPK |
Rosin 分离自松木或松树桩中,是一种频繁接触的过敏原,能够导致过敏性接触性皮炎。 | |||
TN1416 |
Ayanin
|
IL Receptor; P450; PARP; PDE | Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism |
Ayanin 是从Croton schiedeanus Schlecht 中分离得到的黄酮类物质。它是非选择性的磷酸二酯酶抑制剂,在呼吸道疾病中有研究的价值,如过敏性哮喘等。 | |||
T12651 |
Rabdosiin
(+)-Rabdosiin |
Others | Others |
Rabdosiin ((+)-Rabdosiin) 是一种分离自 Rabdosia japonicaHara 中的咖啡酸四聚体,具有抗过敏、抗 HIV 和抑制 DNA 拓扑异构酶作用。 | |||
T4S0878 |
Prunetin
樱黄素,Prunusetin |
ERK; Dehydrogenase; NF-κB | MAPK; Metabolism; NF-κB |
Prunetin (Prunusetin) 是一种O-甲基化异黄酮,具有抗炎的作用。它是人醛脱氢酶的有效抑制剂。 | |||
TN2244 |
Sulfuretin
硫黄菊素 |
NF-κB; Autophagy | Autophagy; NF-κB |
Sulfuretin 是竞争性单酚酶和二酚酶活性抑制剂,IC50=13.64 μM。它通过抑制NF-κB 通路来抑制炎症反应。 它可用于过敏性气道炎症的研究。它减少氧化应激、血小板聚集和诱变。 | |||
T4038 |
Ectoine
THP(B),L-Ectoine,四氢甲基嘧啶羧酸 |
Others; Antibacterial | Microbiology/Virology; Others |
Ectoine (L-Ectoine) 是生活在极其恶劣环境中的细菌所产生的氨基酸衍生物,是一种天然的细胞保护剂。它具有良好的安全性,可研究过敏性鼻炎。它用作渗透调节相容性溶质,可增加皮肤表面的水合作用并稳定脂质层,常用于皮肤护理。 | |||
T2S2173 |
(E)-Naringenin chalcone
Isosalipurpol,柚皮苷查尔酮,Chalconaringenin,trans-2'4'6'4-tetrahydroxychalcone,柚皮素查耳酮 |
Others | Others |
Naringenin chalcone (Isosalipurpol) 是一种黄酮醇生物合成的中间体,在查耳酮异构酶的作用下,自发代谢成柚皮素。它具有抗炎和抗过敏活性。 | |||
T2902 |
Costunolide
Costus lactone,NSC 106404,Costunolid,(+)-Costunolide,木香烃内酯 |
Apoptosis; Endogenous Metabolite; Telomerase | Apoptosis; DNA Damage/DNA Repair; Metabolism |
Costunolide (Costus lactone) 是一种天然的倍半萜内酯,具有抗氧化、抗炎、抗过敏、骨重塑、神经保护、促进毛发生长、抗癌和抗糖尿病的特性,可诱导乳腺癌细胞周期阻滞和凋亡。 | |||
T2982 |
Xanthone
Genicide,呫吨酮,氧杂蒽酮,Xanthenone,Benzophenone oxide |
Apoptosis; Others; Influenza Virus; Antibacterial; Antifungal | Apoptosis; Microbiology/Virology; Others |
Xanthone (Xanthenone) 是一种从山竹果中分离得到的天然产物,具有抗炎,抗氧化,抗肿瘤,抗过敏,抗细菌,抗真菌和抗病毒活性。在癌变的不同阶段可控制细胞分裂和生长,凋亡,炎症和转移。 | |||
T5320 |
Tulipalin A
α-methylene-γ-butyrolactone,2-Methylenebutyrolactone,2-甲烯基丁内酯 |
Others; Drug Metabolite | Metabolism; Others |
Tulipalin A (α-methylene-γ-butyrolactone) 是来源于郁金香鳞茎的有毒糖苷。Tulipalin A 是引起过敏性接触皮炎的致敏性致敏物 (causative allergen),在低剂量影响免疫细胞的功能,例如 Jurkat T 细胞。 | |||
T2S2362 |
Dehydrocorydaline nitrate
去氢延胡索甲素硝酸盐,硝酸脱氢紫堇碱 |
BCL; Others; PARP; p38 MAPK; Caspase; Parasite; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Others; Proteases/Proteasome |
Dehydrocorydaline nitrate 是生物碱。Dehydrocorydaline 调节 Bax,Bcl-2蛋白表达,激活 caspase-7,caspase-8,并使 PARP 失活。它能增强 p38 MAPK 活化,具有抗炎、抗癌、抗疟疾等功效。 | |||
T5666 |
Dipotassium glycyrrhizinate
|
Virus Protease | Microbiology/Virology |
Dipotassium glycyrrhizinate 是一种具有抗过敏和抗炎活性的阴离子表面活性剂。 | |||
T2S0504 |
Ilexoside D
|
Others | Others |
Ilexoside D has ant-allergic, and anti-coagulant activities, it shows anti-tissue factor activity as well as the antithrombotic activity. | |||
T3872 |
Nodakenin
紫花前胡苷,(+)-Marmesinin |
AChE | Neuroscience |
Nodakenin ((+)-Marmesinin) 是一种Peucedanum decursivum Maxim 根中的主要香豆素苷。它能够抑制乙酰胆碱酯酶活性,IC50=84.7 μM。 | |||
T4S2164 |
Narirutin
Naringenin-7-O-rutinoside,Isonaringin,芸香柚皮苷,柚皮芸香苷 |
Others; Antibacterial | Microbiology/Virology; Others |
Narirutin (Naringenin-7-O-rutinoside) 是从Citrus unshiu 中分离的活性成分之一,具有抗氧化和抗炎活性。它是一种具有抗结核效力的shikimate 激酶抑制剂。 | |||
TMA1570 |
Sappanone A
|
NF-κB; Nrf2 | Immunology/Inflammation; NF-κB |
Sappanone A 是一种高异黄烷酮,通过调节 Nrf2 和 NF-κB 表现出抗炎作用。Sappanone A 可以减轻卵清蛋白引起的哮喘中的过敏性气道炎症。 | |||
TN1040 |
Skullcapflavone II
|
COX; Antibacterial; TGF-beta/Smad | Immunology/Inflammation; Microbiology/Virology; Neuroscience; Stem Cells |
Skullcapflavone II 是从黄芩中提取的黄酮,具有抗炎作用。它对 M. aurum 和 M. bovisBCG 具有较强的抗菌活性。它还调节破骨细胞的分化、存活和功能。 | |||
T4946 |
(+)-Columbianetin acetate
二氢欧山芹醇醋酸酯,COLUMBIANETIN ACETATE |
Others | Others |
(+)-Columbianetin acetate (COLUMBIANETIN ACETATE) 是一种 Columbianetin 异构体。其中Columbianetin 是植物抗毒素,与芹菜贮藏过程中对病原体的抗性有关,表现出良好的抗炎及抗真菌活性。 | |||
TN1088 |
3,5,6,7,8,3',4'-Heptemthoxyflavone
3,3',4',5,6,7,8-heptamethoxyflavone,3,5,6,7,8,3',4'-七甲氧基黄酮 |
Others | Others |
3,5,6,7,8,3',4'-Heptemthoxyflavone 是来自蜜柑皮中的黄酮,具有抗肿瘤起始活性和抗神经炎症作用。它能通过 cAMP/ERK/CREB 信号诱导脑源性神经营养因子表达,降低 C6 细胞磷酸二酯酶活性。它能抑制胶原酶的活性,增加人真皮成纤维细胞新生细胞中 I 型前胶原含量。 | |||
TN1712 |
Gossypin
|
NF-κB; S6 Kinase | MAPK; NF-κB; PI3K/Akt/mTOR signaling |
Gossypin 是一种从Hibiscus vitifolius 中分离得到的黄酮,能够抑制NF-κB 和 NF-κB 的调节基因表达。在小鼠原代骨髓细胞和 RAW264.7 细胞中,它也可抑制 RANKL 诱导的破骨细胞形成。它具有抗氧化、抗炎、抗癌、抗衰老、抗糖尿病和保护肝脏的活性。 | |||
TN1470 |
Cassiaside B2
决明子苷B2 |
Phosphatase; MAO; 5-HT Receptor | GPCR/G Protein; Metabolism; Neuroscience |
Cassiaside B2 是蛋白酪氨酸磷酸酶1B (PTP1B) 和人单胺氧化酶A (hMAO-A) 的抑制剂。Cassiaside B2是 5-HT2C 受体的激动剂, 具有抗过敏活性。Cassiaside B2 是萘吡喃酮参比提取物(NRE)的有效成分之一。 | |||
T5S1285 |
(+)-(3R,8S)-Falcarindiol
Falcarindiol,镰叶芹二醇 |
Others | Others |
(+)-(3R,8S)-Falcarindiol 是一种从胡萝卜中得到的聚乙炔,有抗炎、抗肿瘤和抗脂质过氧化活性。它具有抗分歧杆菌作用,对Mycobacterium tuberculosisH37Ra 的 MIC 和 IC50值分别为 24 μM 和 6 μM。 | |||
TN1516 |
Cnidicin
蛇床素,4,9-双[(3-甲基-2-丁烯-1-基)氧基]-7H-呋喃并[3,2-G][1]苯并吡喃-7-酮 |
NOS; NO Synthase | Immunology/Inflammation |
Cnidicin 是一种香豆素,对肥大细胞脱颗粒及 RAW 264.7 细胞产生一氧化氮具有抑制作用。 | |||
T5S1286 |
(+)-Columbianetin
二氢山芹醇,(S)-Columbianetin,Columbianetin |
Antifungal | Microbiology/Virology |
(+)-Columbianetin ((S)-Columbianetin) 是 Columbianetin 的异构体。其中Columbianetin 是一种植物抗毒素,与芹菜贮藏过程中对病原体的抗性有关,具有良好的抗真菌和抗炎作用。 | |||
T6S0117 |
Avicularin
Fenicularin,扁蓄苷 |
ERK | MAPK |
Avicularin (Fenicularin) 具有抗过敏、抗炎、保肝、抗氧化、抗肿瘤等活性。它能通过调节 NF-κB(p65)、COX-2 和 PPAR-γ 的活性来改善人类肝细胞癌。在 LPS 刺激的 RAW 264.7 巨噬细胞中,它通过抑制 ERK 信号通路产生抗炎活性。 | |||
T17214 |
Valencene
NSC 148969,NSC-148969,NSC148969 |
Others; Antioxidant; NF-κB | NF-κB; Others; oxidation-reduction |
Valencene (NSC-148969) 是一种从 Cyperus rotundus 中分离出来的倍半萜类化合物,是柑橘类水果和柑橘类衍生气味的香气成分。ValenceneValencene 具有抗过敏、抗炎、抗黑色素生成、和抗氧化活性。通过阻断 NF-κB 通路,Valencene 通过阻断 NF-κB 通路抑制 Th2 趋化因子和促炎性趋化因子的过度表达。 | |||
T4518 |
Licochalcone D
|
ERK; NF-κB | MAPK; NF-κB |
Licochalcone D 是一种 NF-κB p65的有效抑制剂,是一种存在于 Glycyrrhiza inflate 中的黄酮类化合物,具有抗氧化、抗炎、抗癌等作用。 | |||
T4S1943 |
Kirenol
奇壬醇,奇任醇,Kirel |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Kirenol (Kirel) 是分离自 Siegesbeckia orientalis 中的,具有抗氧化、抗炎、抗过敏、抗关节炎活性,可用于缓解疼痛的研究。 | |||
T2520 |
Desloratadine
Sch34117,地氯雷他定,NSC 675447 |
Endogenous Metabolite; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience |
Desloratadine (Sch34117) 是非镇静H1抗组胺药 Loratadine 的主要口服代谢物,可减少对支气管平滑肌、毛细血管和胃肠道平滑肌中 H1 受体的典型组胺能作用,包括血管舒张、支气管收缩、血管通透性增加、疼痛、瘙痒和胃肠道平滑肌的痉挛性收缩。它是一种选择性H1受体拮抗剂,具有抗过敏和抗炎活性。 | |||
T3S1612 |
kuwanon G
桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G |
Phosphatase; Antibacterial; Bombesin Receptor; AChR; AChE; Glucosidase | GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience |
Kuwanon G (Moracenin B) 是一种从桑树中得到的黄酮类蛙皮素受体拮抗剂,具有杀菌作用。 | |||
TN3482 |
Bakkenolide B
|
NOS; COX | Immunology/Inflammation; Neuroscience |
Bakkenolide B has suppressive properties for allergic and inflammatory responses and may be utilized as a potent agent for the treatment of asthma. | |||
TN3483 |
Bakkenolide D
|
IL Receptor; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Bakkenolide D has anti-allergic effect, it and bakkenolide D demonstrates inhibitory effect on the trachea contraction induced by histamine in vitro, they have obvious anti-histamine activities. | |||
TN5062 | Stigmast-4-ene-3,6-dione | ||
Stigmast-4-ene-3,6-dione has anti-inflammatory and anti-allergic properties. | |||
TN7449 |
8-Hydroxy-5,7-dimethoxyflavanone
|
Others | Others |
8-Hydroxy-5,7-dimethoxyflavanone (PDMF) is a phytochemical with tumor-preventive properties, promoting p53-driven G2/M cell cycle arrest and apoptosis. It is a potent anti-allergic agent for preventing IgE-driven hypersensitivity reactions and possesses anti-inflammatory activity. | |||
T39570 |
Cycloartenyl ferulate
Cycloartenolferulate,Cycloartenolferulicacidester,环木菠萝烯醇阿魏酸酯 |
Others | Others |
Cycloartenyl ferulate (also known as cycloartenol ferulate) is a representative triterpene alcohol with diverse biological properties, such as antioxidant, anti-allergic, anti-inflammatory, and anticancer activities. | |||
TN3836 |
Desacetylmatricarin
|
Others | Others |
Desacetylmatricarin has anti-allergic property, it shows a potent inhibitory activity upon the beta-hexosaminidase release from RBL-2H3 cells in a dose-dependent manner and the IC50 of 7.5 microM. | |||
TN4429 |
Leucodin
|
MMP; TNF | Apoptosis; Proteases/Proteasome |
Leucodin shows high anti-hypercholesterolemic potential. Leucodin may have anti-allergic activity, it shows a potent inhibitory activity upon the beta-hexosaminidase release from RBL-2H3 cells in a dose-dependent manner with IC50 of 80 microM. | |||
TN3513 |
Bis-5,5-nortrachelogenin
|
Others | Others |
Bis-5,5-nortrachelogenin has anti-allergic activity, it inhibited NO production with IC50 value of 48.6 microM. | |||
TN1845 |
Kushenol N
|
Others | Others |
Kushenol N may have anti-allergic activity, it demonstrates significant inhibition of the release of beta-hexosaminidase from cultured RBL-2H3 cells . | |||
TN3936 |
ent-16-Kaurene-3beta,15beta,18-triol
|
Others | Others |
ent-16-Kaurene-3beta,15beta,18-triol, ent-16-kaurene-3beta,15beta-diol,abbeokutone,and helioscopinolide A possess appreciable anti-allergic activities in RBL-2H3 cells model with IC50 values ranging from 22.5 to 42.2 microM. | |||
TN4392 |
Koaburaside
|
IL Receptor; TNF; Influenza Virus | Apoptosis; Immunology/Inflammation; Microbiology/Virology |
Koaburaside exhibits antioxidant activity with an IC50 value of 9.0μM, it shows weak inhibitory activity against influenza A neuraminidase. Koaburaside may have anti-allergic inflammatory activity, it can suppress histamine release from mast cells. | |||
TN3325 |
9-O-Feruloyl-5,5'-dimethoxylariciresinol
|
IL Receptor; TNF | Apoptosis; Immunology/Inflammation |
(+)-9'-O-trans-feruloyl-5,5'-dimethoxylariciresinol may have anti-allergic inflammatory effect, it can inhibit release of histamine from mast cells. It shows cytotoxicity against a small panel of human tumor cell lines, with ED50 values of 9.86 to approxi | |||
TN3870 |
Iriflophenone 2-O-Rhamnoside
Dimethylmatairesinol |
Others | Others |
Dimethylmatairesinol can reduce the amount of Immunoglobulin E (IgE) secreted by human myeloma U266 cells, it has potential as an anti-allergic agent. Dimethylmatairesinol also exhibits significant cytotoxicity against three human tumor cells(A-549 lung c | |||
T82248 |
Gymnoside I
|
||
Gymnoside I(化合物1)是糖苷氧基苄基2-异丁基苹果酸,其在小鼠被动皮肤过敏反应(PCA)实验中展现出抗过敏效能。该化合物有望在哮喘、神经衰弱和慢性肝炎治疗研究中应用。 | |||
TN5033 |
Skullcapflavone I
|
IL Receptor; Caspase; Prostaglandin Receptor | Apoptosis; GPCR/G Protein; Immunology/Inflammation; Proteases/Proteasome |
Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages and inhibit LPS induced IL-6 production in a concentration dependent manner. Skullcapflavone I se | |||
T75499 |
Maceneolignan H
|
Others | Others |
Maceneolignan H (Compound 8)是一种新的木脂素化合物,从肉豆蔻假种皮中分离而来。它表现为选择性CCR3拮抗剂(EC50=1.4 μM),具有研究过敏性疾病潜力。 | |||
TN2511 |
Britannilactone diacetate
1,6-O,O-Diacetylbritannilactone |
IL Receptor; PARP; ROS; MAPK; Caspase; JAK; JNK; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; JAK/STAT signaling; MAPK; Proteases/Proteasome; Stem Cells |
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airway disease as a lead compound. OODBL has anti-asthmatic activity, it reduces leukotriene C4 pro | |||
TN4489 | Manassantin A | ERK; cAMP; TNF; NF-κB; MAPK; COX; HIF; Prostaglandin Receptor; JNK; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; MAPK; Neuroscience; NF-κB; Stem Cells |
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX/PGE2 stimulation, inhibition of iNOS production and NF-κB act |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIJ-0328 |
Mometasone furoate-d3
|
||
Mometasone furoate-d3 是 Mometasone furoate 的氘代化合物。Mometasone furoate 的 CAS 号为 83919-23-7。Mometasone furoate 是糖皮质激素受体激动剂,具有抗炎和抗过敏作用。它是皮质固醇类试剂,动物模型中,可局部应用于气道炎症、慢性皮肤湿疹、哮喘。 | |||
TMIJ-0498 |
Fluticasone Propionate-d5
|
||
Fluticasone Propionate-d5 是 Fluticasone Propionate 的氘代化合物。Fluticasone Propionate 的 CAS 号为 80474-14-2。Fluticasone propionate 是一种选择性糖皮质激素受体激动剂,是一种局部抗炎激素,绝对亲和力KD为 0.5 nM。具有抗病毒活性。 | |||
T71329 |
Theophylline-d6
|
||
Theophylline-d6 is intended for use as an internal standard for the quantification of theophylline by GC- or LC-MS. Theophylline is an inhibitor of phosphodiesterase. It is also an adenosine A1 and A2 receptor antagonist. Theophylline induces relaxation of isolated cat bronchial smooth muscle segments precontracted with acetylcholine. It inhibits ovalbumin-induced increases in bronchoalveolar lavage fluid (BALF) eosinophil infiltration in an ovalbumin-sensitized mouse model of allergic asthma. F... | |||
TMIJ-0200 |
Loratadine-d5
|
||
Loratadine-d5 是 Loratadine 的氘代化合物。Loratadine 的 CAS 号为 79794-75-5。Loratadine是一种组胺 H1受体反向激动剂,IC50>32 μM。它抑制炎症介质的免疫释放,具有抗登革热病毒的活性。 | |||
TMIJ-0505 |
Fluticasone Furoate-d3
|
||
Fluticasone Furoate-d3 是 Fluticasone Furoate 的氘代化合物。Fluticasone Furoate 的 CAS 号为 397864-44-7。Fluticasone furoate 是一种合成的三氟化皮质类固醇,衍生自氟替卡松,Kd 为 0.3 nM。Fluticasone furoate 具有有效的抗炎、抗哮喘活性和低全身暴露。Fluticasone furoate 可用作过敏性鼻炎治疗研究的鼻喷雾剂。 | |||
TMID-0006 |
Budesonide-d8
mixture of diastereomers-d8 |
||
Budesonide-d8 是 Budesonide 的氘代化合物。Budesonide 的 CAS 号为 51333-22-3。Budesonide 是吸入型糖皮质类固醇,是一种口服具有活性的糖皮质激素受体激动剂。它能够减小肺部肿瘤的体积,逆转 DNA 低度甲基化,调节基因的 mRNA 表达。它是能够用于哮喘的抗炎药。 | |||
TMIJ-0202 |
Desloratadine-d5
|
||
Desloratadine-d5 是 Desloratadine 的氘代化合物。Desloratadine 的 CAS 号为 100643-71-8。Desloratadine 是非镇静H1抗组胺药 Loratadine 的主要口服代谢物,可减少对支气管平滑肌、毛细血管和胃肠道平滑肌中 H1 受体的典型组胺能作用,包括血管舒张、支气管收缩、血管通透性增加、疼痛、瘙痒和胃肠道平滑肌的痉挛性收缩。它是一种选择性H1受体拮抗剂,具有抗过敏和抗炎活性。 |