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Search Results for " aggressive "

Targets Recommended: Others HIV Protease

18

抑制剂 & 化合物

13

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T2556	Nandrolone decanoate 癸酸诺龙,19-Nortestosterone decanoate	Others; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	Nandrolone decanoate (19-Nortestosterone decanoate) 是一种合成代谢雄激素，通过涉及谷氨酸诱导的 N-甲基-D-天冬氨酸受体过度兴奋的机制诱导攻击性行为表征。
T23483	U 99194 maleate U-99194A maleate,U-99194 maleate salt,U-99194 maleate	Dopamine Receptor	GPCR/G Protein; Neuroscience
	U 99194 maleate (U-99194A maleate) 是一种 D3 拮抗剂，可增加隔离诱导的攻击性雄性小鼠的社会行为。
T11421	Glutaminase-IN-1 CB839 derivative	transporter	Metabolism
	Glutaminase-IN-1 (CB839 derivative)，是一种新型 1,3,4-硒二氮基肾型谷氨酰胺酶(KGA) 的变构抑制剂，在侵袭性 H22 肝癌异种移植模型中显示出抗肿瘤活性。
T0609	Azobenzene 偶氮苯,Diazene,Diphenyldiazene	Others	Others
	Azobenzene是一种光触发器，可用于设计和合成各种光响应系统。Azobenzene 具有遗传毒性，可诱发脾脏和其他腹部器官的侵袭性肉瘤。
T78526	4A3-SC8 4A3 SC8,4A3SC8	Liposome	Metabolism
	4A3-SC8 为一种具有阳离子基团和亲脂基团的模块化树枝状大分子，可在侵袭性肝癌模型中使小RNA延长生存期，可用于合成脂质纳米颗粒。
T3275	Nefazodone hydrochloride Dutonin,MJ-13754-1,Serzone,BMY-13754-1,BMY-13754,萘法唑酮盐酸盐	5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Nefazodone hydrochloride (Serzone) 是一种强效和选择性的5HT2A 拮抗剂，Ki 为5.8 nM，对 5-HT 和去甲肾上腺素摄取具有中度抑制作用，IC50分别为 290 和 300 nM。它是一种苯哌嗪类抗抑郁药，具有微弱的 α-肾上腺素阻断活性，用于治疗抑郁症、攻击性行为和恐慌症。
T17206	UPGL00004	Others; Glutaminase	Others; Proteases/Proteasome
	UPGL00004 是一种有效的谷氨酰胺酶 C (GAC) 抑制剂，其 IC50为29 nM。UPGL00004 对 GAC 的 Kd 为27 nM。UPGL00004 对高度侵袭性三阴性乳腺癌细胞系的增殖具有很强的抑制作用。
T24519	Naprodoxime HCl Naprodoxime hydrochloride,L 7660,L7660,L-7660	Others	Others
	Naprodoxime HCl is an antidepressant. It also is an anti-aggressive agent.
T28850	SR57227A SR 57227A,SR-57227A	Others	Others
	SR 57227A is a highly selective of peripheral and central 5-HT3 receptors and an inhibitor of NMDA receptor-mediated responses in rat cortical pyramidal cells. It exhibits anti-depressant like effects in rats and decreased isolation-induced aggressive beh
T68189	Anpirtoline free base	Others	Others
	Anpirtoline free base is a highly potent 5-HT1B receptor agonist. Anpirtoline has been shown to decreases central serotonin synthesis and attenuate aggressive behavior in vivo. Anpirtoline also acts as an antagonist at 5-HT3 receptors and can bypass the blood-brain barrier.
T60794	HDAC10-IN-1	Others	Others
	HDAC10-IN-1 (化合物 13b) 是一种有效且高选择性的HDAC10抑制剂 (IC 50 = 58 nM)，可用于调节侵袭性 FLT3-ITD 阳性急性髓系白血病细胞的自噬。
T78145	HDAC10-IN-2 hydrochloride	Autophagy	Autophagy
	HDAC10-IN-2 hydrochloride（化合物10c）是一种对HDAC10具有高效性和高选择性的抑制剂，IC50值为20 nM。该化合物能够调控FLT3-ITD阳性急性髓系白血病细胞的自噬过程。
T60760	HDAC10-IN-2	Others	Others
	HDAC10-IN-2 (化合物 10c) 调节侵袭性 FLT3-ITD 阳性急性髓系白血病细胞的自噬。HDAC10-IN-2是HDAC10的高选择性抑制剂 (IC50 = 20 nM)。
T80981	Tisagenlecleucel CTL019
	Tisagenlecleucel (CTL019) 是一种自体抗CD19嵌合抗原受体 (CAR) T 细胞治疗，专门针对并消除表达CD19的 B 细胞。该疗法主要用于研究治疗难治性侵袭性弥漫性大 B 细胞淋巴瘤。
T63368	CDK7-IN-2	Others	Others
	CDK7-IN-2 是 CDK7 的有效抑制剂。其中 CDK7 利用 RNA 聚合酶 II (RNAPII) 的 Rbpl 亚基的磷酸化参与转录起始过程，其与细胞周期和转录活性的时间控制有关。CDK7 对癌症疾病，尤其是侵袭性和难以治疗的癌症具有研究潜力。
T68400	STA-9584	Others	Others
	STA-9584 is a potent vascular disrupting agent, which exhibits potent antitumor activity by selectively targeting microvasculature at both the center and periphery of tumors. In vitro, 2-methoxy-5-(5-(3,4,5-trimethoxyphenyl)isoxazol-4-yl)aniline (STA-9122) (active metabolite of STA-9584 ) displayed increased potency relative to other tubulin-binding agents and was highly cytotoxic to tumor cells. STA-9584 induced significant tumor regressions in prostate and breast xenograft models in vivo and, ...
T63902	XP-524	Others	Others
	XP-524 是 BET 和 EP300 的有效抑制剂。 XP-524 在体内具有显著的杀肿瘤作用，能够阻止 KRAS 诱导的体内肿瘤转化，并延长两种侵袭性 PDAC 转基因小鼠模型的存活时间。XP-524 也提高了自身肽的表达及将肿瘤细胞向细胞毒性 T 淋巴细胞的募集。XP-524 对胰腺导管腺癌（PDAC）表现出研究潜力。
T38145	Eltoprazine	Others	Others
	Eltoprazine(DU28853) is a serenic or antiaggressive agent which as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor.IC50 value:Target: 5-HT1A/1B agonist; 5-HT2C antagonistin vitro: The binding of [3H]eltoprazine to whole tissue sections was saturable and revealed an apparent dissociation constant (Kd) of 11 nM. Specific [3H]eltoprazine binding was completely displaced by 5-HT; conversely, unlabelled eltoprazine reduced [3H]5-HT binding to the levels of no...

化合物

Nandrolone decanoate

Cat.No: T2556

Synonym: 癸酸诺龙,19-Nortestosterone decanoate

Target: Others, HIV Protease

U 99194 maleate

Cat.No: T23483

Synonym: U-99194A maleate,U-99194 maleate salt,U-99194 maleate

Target: Dopamine Receptor

Glutaminase-IN-1

Cat.No: T11421

Synonym: CB839 derivative

Target: transporter

Cat.No: T0609

Synonym: 偶氮苯,Diazene,Diphenyldiazene

Target: Others

Cat.No: T78526

Synonym: 4A3 SC8,4A3SC8

Target: Liposome

Nefazodone hydrochloride

Cat.No: T3275

Synonym: Dutonin,MJ-13754-1,Serzone,BMY-13754-1,BMY-13754,萘法唑酮盐酸盐

Target: 5-HT Receptor, Adrenergic Receptor

Cat.No: T17206

Target: Others, Glutaminase

Naprodoxime HCl

Cat.No: T24519

Synonym: Naprodoxime hydrochloride,L 7660,L7660,L-7660

Target: Others

Cat.No: T28850

Synonym: SR 57227A,SR-57227A

Target: Others

Anpirtoline free base

Cat.No: T68189

Target: Others

Cat.No: T60794

Target: Others

HDAC10-IN-2 hydrochloride

Cat.No: T78145

Target: Autophagy

Cat.No: T60760

Target: Others

Tisagenlecleucel

Cat.No: T80981

Synonym: CTL019

Cat.No: T63368

Target: Others

Cat.No: T68400

Target: Others

Cat.No: T63902

Target: Others

Cat.No: T38145

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01882	PARP9 Protein, Human, Recombinant (His) PARP9,Poly [ADP-ribose] polymerase 9,ADP-ribosyltransferase ...	Human	E. coli
	PARP9 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 30.0 kDa and the accession number is Q8IXQ6.
TMPH-01944	PARP9 Protein, Human, Recombinant (His & Myc) Poly [ADP-ribose] polymerase 9,ADP-ribosyltransferase diphth...	Human	HEK293 Cells
	PARP9 Protein, Human, Recombinant (His & Myc) is expressed in HEK293.
TMPH-01942	PARP14 Protein, Human, Recombinant (His & Myc) Protein mono-ADP-ribosyltransferase PARP14,B aggressive<...	Human	HEK293 Cells
	PARP14 Protein, Human, Recombinant (His & Myc) is expressed in HEK293.
TMPY-04764	PCK2 Protein, Human, Recombinant (His & GST) PEPCK-M,PEPCK2,PEPCK,phosphoenolpyruvate carboxykinase 2 (mi...	Human	Baculovirus Insect Cells
	PCK2 promotes tumor initiation by lowering acetyl-CoA level through reducing the mitochondrial tricarboxylic acid (TCA) cycle. The levels of phosphoenolpyruvate carboxykinase isoform 2 (PCK2) are critical for the metabolic switch and the maintenance of TICs in prostate cancer. PCK2 is a potential therapeutic target for aggressive prostate tumors.
TMPY-00361	Pellino-1 Protein, Human, Recombinant (His & GST) pellino E3 ubiquitin protein ligase 1,PRISM	Human	Baculovirus Insect Cells
	PELI is a family of E3 ubiquitin ligases that regulate protein activity through a post-translational modification, ubiquitination. PELI1 may function to control inadvertent activation of RIP3, thus preventing aberrant cell death and maintaining cellular homeostasis. PELI1 might participate in B-cell maturation or oncogenic activation of aggressive B-cell lymphomas, both during and after germinal center stages.
TMPK-01217	MFAP5 Protein, Mouse, Recombinant (hFc) MP25,AAT9,MAGP2,MAGP-2,MFAP-5	Mouse	HEK293 Cells
	Human basal-like breast cancer (BLBC) is an aggressive malignancy with poor prognosis. Since most current treatments are ineffective, there is an urgent need to identify therapeutic targets for BLBC. Microfibrillar-associated protein 5 (MFAP5) plays an important role in the integration of elastic microfibers and the regulation of endothelial cell behaviors.MFAP5 was significantly overexpressed in BLBC tissues and associated with poor metastasis-free survival of patients with BLBC. MFAP5 Protein,...
TMPJ-00859	AREG Protein, Human, Recombinant AR,CRDGF,Amphiregulin,Colorectum Cell-Derived Growth Factor,...	Human	E. coli
	Amphiregulin (AREG) is a single-pass membrane protein with 252 amino acids. AREG belongs to the amphiregulin family, which contains 1 EGF-like domain. AREG is expressed in a variety of tissues including ovary, placenta, lung, kidney, stomach, colon, and breast. It is related to Epidermal Growth Factor (EGF) and Transforming Growth Factor Alpha (TGF-alpha). As an EGF-related growth factor, AREG interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits...
TMPK-00933	ADAM8/CD156a Protein, Mouse, Recombinant (His) CD156a,MGC134985,ADAM 8,Ms2,Adam8	Mouse	HEK293 Cells
	A Disintegrin And Metalloproteinase (ADAM) proteases constitute a family of multifunctional, membrane-bound proteins with traditional sheddase functions. Their protumorigenic potential has been attributed to both, essential (ADAM10 and ADAM17) and 'dispensable' ADAM proteases (ADAM8, 9, 12, 15, and 19). Of specific interest in this review is the ADAM proteinase ADAM8 that has been identified as a significant player in aggressive malignancies including breast, pancreatic, and brain cancer. ADAM8/...
TMPK-00957	MFAP5 Protein, Human, Recombinant (hFc) MAGP2,AAT9,MAGP-2,MP25,MFAP-5	Human	HEK293 Cells
	Human basal-like breast cancer (BLBC) is an aggressive malignancy with poor prognosis. Since most current treatments are ineffective, there is an urgent need to identify therapeutic targets for BLBC. Microfibrillar-associated protein 5 (MFAP5) plays an important role in the integration of elastic microfibers and the regulation of endothelial cell behaviors.MFAP5 was significantly overexpressed in BLBC tissues and associated with poor metastasis-free survival of patients with BLBC. MFAP5 Protein,...
TMPK-00918	ADAM8/CD156a Protein, Human, Recombinant (aa 17-655, His) CD156a,ADAM 8,MGC134985,Adam8,Ms2	Human	HEK293 Cells
	A Disintegrin And Metalloproteinase (ADAM) proteases constitute a family of multifunctional, membrane-bound proteins with traditional sheddase functions. Their protumorigenic potential has been attributed to both, essential (ADAM10 and ADAM17) and 'dispensable' ADAM proteases (ADAM8, 9, 12, 15, and 19). Of specific interest in this review is the ADAM proteinase ADAM8 that has been identified as a significant player in aggressive malignancies including breast, pancreatic, and brain cancer. ADAM8/...
TMPY-03047	Stathmin 1 Protein, Human, Recombinant (His) SMN,OP18,stathmin 1,LAP18,C1orf215,PP17,Lag,PP19,PR22	Human	E. coli
	Stathmin1 (STMN1) is a cytosolic phosphoprotein that regulates cellular microtubule dynamics and is known to have oncogenic activity. STMN1 is a possible biomarker for paclitaxel sensitivity and poor prognosis in GC and could be a novel therapeutic target in metastatic GC. STMN1 expression might serve as a biomarker for determining patient atypical meningioma prognosis. Stathmin1 (STMN1) is a cytosolic protein involved in microtubule dynamics through inhibition of tubulin polymerization and prom...
TMPY-04930	Notch 2 Protein, Human, Recombinant (His) AGS2,HJCYS,hN2,notch 2	Human	Baculovirus Insect Cells
	NOTCH2 (Notch Receptor 2) is a Protein Coding gene. This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics and play a role in a variety of developmental processes by controlling cell fate decisions. Hajdu Cheney Syndrome (HCS) is a rare disease associated with mutations of NOTCH2 that lead to the translation of a truncated, presumably stable, NOTCH2 protein. NOTCH2 is down-regulated in colon cancer, and reduced express...
TMPY-01926	S100A10 Protein, Human, Recombinant (His) ANX2L,S100 calcium binding protein A10,p10,CLP11,MGC111133,G...	Human	E. coli
	S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S1 proteins have been implicated in a variety of int...

重组蛋白

PARP9 Protein, Human, Recombinant (His)

Cat.No: TMPH-01882

Species: Human

Expression System: E. coli

PARP9 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01944

Species: Human

Expression System: HEK293 Cells

PARP14 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01942

Species: Human

Expression System: HEK293 Cells

PCK2 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04764

Species: Human

Expression System: Baculovirus Insect Cells

Pellino-1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-00361

Species: Human

Expression System: Baculovirus Insect Cells

MFAP5 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01217

Species: Mouse

Expression System: HEK293 Cells

AREG Protein, Human, Recombinant

Cat.No: TMPJ-00859

Species: Human

Expression System: E. coli

ADAM8/CD156a Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00933

Species: Mouse

Expression System: HEK293 Cells

MFAP5 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00957

Species: Human

Expression System: HEK293 Cells

ADAM8/CD156a Protein, Human, Recombinant (aa 17-655, His)

Cat.No: TMPK-00918

Species: Human

Expression System: HEK293 Cells

Stathmin 1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03047

Species: Human

Expression System: E. coli

Notch 2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04930

Species: Human

Expression System: Baculovirus Insect Cells

S100A10 Protein, Human, Recombinant (His)

Cat.No: TMPY-01926

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T70960	Maprotiline-d3 hydrochloride
	Maprotiline-d3 is intended for use as an internal standard for the quantification of maprotiline by GC- or LC-MS. Maprotiline is a tricyclic antidepressant. It binds to the norepinephrine transporter (NET) and is selective for NET over the serotonin and dopamine transporters. Maprotiline also binds to the serotonin (5-HT) receptor subtype 5-HT2A, as well as histamine H1, muscarinic acetylcholine, α1-adrenergic, and dopamine D2 receptors. In vivo, maprotiline inhibits norepinephrine reuptake in r...

同位素标记化合物

Maprotiline-d3 hydrochloride

Cat.No: T70960

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