35
8
11
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T61953 |
Zika virus-IN-2
|
Others | Others |
Zika virus-IN-2 (Compd 3) 是Zika 病毒的抑制剂(EC50= 7.4 μM)。 | |||
T61762 |
Zika virus-IN-3
|
Others | Others |
Zika virus-IN-3 (Compd 7) 是Zika 病毒的抑制剂,其EC50值为 3.4 μM。 | |||
T63586 |
Zika virus-IN-1
|
Others | Others |
Zika virus-IN-1 是一种 Zika 病毒的抑制剂 (EC50: 1.56 μM)。 | |||
T23004 |
ML-SA1
Mucolipin synthetic agonist 1 |
Others; TRP/TRPV Channel | Membrane transporter/Ion channel; Others |
ML-SA1 (Mucolipin synthetic agonist 1) 是一种选择性的TRPML 激动剂,通过促进溶酶体的酸化和蛋白酶活性抑制登格病毒 2 和寨卡病毒,抗 DENV2 RNA 和 ZIKV RNA 的IC50分别为 8.3 μM 和 52.99 μM。ML SA1可诱发自噬。ML SA1可用于广谱抗病毒研究。 | |||
T6826 |
Emricasan
PF 03491390,恩利卡生,IDN-6556 |
Influenza Virus; Caspase | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Emricasan (IDN-6556) 是一种泛的 caspase 抑制剂,具有不可逆性。Emricasan 具有抗炎和抗凋亡活性,可以用于治疗感染和肝衰竭等。Emricasan 还可以抑制 Zika 病毒感染。 | |||
T72051 |
LabMol-319
|
Virus Protease | Microbiology/Virology |
LabMol-319 是一种有效的寨卡病毒 (ZIKV) NS5 RdRp 抑制剂,具有抗病毒活性,可用于研究 ZIKV 病毒。 | |||
T16325 |
NITD008
7-Deaza-2'-C-acetylene-adenosine |
Others | Others |
NITD008 (7-Deaza-2'-C-acetylene-adenosine) 是一种有效的和选择性的腺苷核苷抑制剂,是一种腺苷核苷类似物,具有广谱的抗病毒活性,抑制登革热病毒、动物杯状病毒和寨卡病毒。 | |||
T25130 |
Azaribine
2',3',5'-Tri-O-acetyl-6-azauridine,NSC 67239 |
Antiviral | Immunology/Inflammation |
Azaribine (2;,3;,5;-Tri-O-acetyl-6-azauridine) 是一种乳清碱单磷酸脱羧酶 (OMPD) 抑制剂,具有广谱的抗病毒活性,可抑制病毒基因组复制和基因转录。Azaribine 可用于研究寨卡病毒 (ZIKV)感染,可用于研究银屑病关节炎和蕈样肉芽肿。 | |||
TNU0007 |
3'-Deoxy-3'-fluoroadenosine
|
Nucleoside Antimetabolite/Analog | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
3'-Deoxy-3'-fluoroadenosine 是一种嘌呤核苷类似物,具有广泛的抗肿瘤活性和抗病毒活性,对蜱传脑炎病毒(TBEV),寨卡病毒和西尼罗河病毒(WNV)具有抑制作用,EC50分别为1.1μM、 0.1 μM和4.7 1.5 μM。3'-Deoxy-3'-fluoroadenosine可用于研究肿瘤疾病。 | |||
T0265 |
Merbromin
红汞,Mercury dibromofluorescein disodium salt |
Others; Antibacterial | Microbiology/Virology; Others |
Merbromin (Mercury dibromofluorescein disodium salt) 有效抑制 Zika 病毒 (ZIKV) 复制,通过抑制 ZIKVpro 表现出抗 ZIKV 效力。它用作割伤和擦伤的局部消毒剂,并用作生物染料。 | |||
T69942 |
CN-716 HCl
|
Others | Others |
cn-716 is a novel Zika virus (ZIKV) NS2B-NS3pro protease inhibitor. | |||
T63125 |
Antiviral agent 19
|
Others | Others |
Antiviral agent 19 (Compound 3) 是一种 Zika 病毒的选择性抑制剂 (EC50: 1.3 μM),具有低细胞毒性。 | |||
T73292 |
ZIKV-IN-3
|
Others | Others |
ZIKV-IN-3, 一个穿心莲内酯衍生物,作为有效的ZIKV NS5甲基转移酶(MTase)抑制剂,展示了18.34 μM的IC50值。该化合物能抑制ZIKV的复制与感染,适用于寨卡病毒(ZIKV)的研究。 | |||
T69186 |
CP26
|
Others | Others |
CP26 is a novel inhibitor of ER-to-cytosol protein dislocation, exhibiting anti-dengue and anti-Zika virus activity. | |||
T81642 |
NS2B-NS3pro-IN-1
|
Virus Protease | Microbiology/Virology |
NS2B-NS3pro-IN-1为Zika Virus NS2B-NS3蛋白酶抑制剂,具有50 μM的EC50值,对Zika Virus (ZIKV)循环具有关键影响。 | |||
T69416 |
JMX0207
|
Others | Others |
JMX0207 is a novel inhibitor of viral protease function, suppressing Zika virus Infection both In vitro and In vivo. | |||
T64166 |
Antiviral agent 20
|
Others | Others |
Antiviral agent 20 (Compound 17b) 是一种 Zika 病毒的选择性抑制剂 (EC50: 4.5 μM),表现出低细胞毒性。 | |||
T80760 |
XSJ2-46
|
Influenza Virus | Microbiology/Virology |
XSJ2-46,一种5'-氨基NI类似物,表现为有效的抗病毒药物,尤其针对Zika病毒。它通过抑制RNA依赖性RNA聚合酶(RdRp),展示出其活性,具有8.78 μM的IC50值。 | |||
T14658 |
Bis-propargyl-PEG5
|
Others | Others |
Bis-propargyl-PEG5 serves as a PEG-based PROTAC linker, facilitating the synthesis of PROTACs. This chemical compound is particularly employed in the synthesis of carbohydrate receptors (SCRs) with anti-Zika activity[1]. | |||
T72887 |
NS2B/NS3-IN-7
|
Others | Others |
NS2B/NS3-IN-7 是一种高效的寨卡病毒 (Zika virus)NS2B-NS3 蛋白酶抑制剂,Ki 为 2.33 nM。NS2B/NS3-IN-7 能减少寨卡病毒感染的细胞数量。 | |||
T67784 |
6-fluorinated-aristeromycin2c
|
Others | Others |
6-fluorinated-aristeromycin2c 具有抗病毒感染活性,对热病毒、寨卡病毒和Sars 冠状病毒具有抑制作用。 | |||
T63131 |
ZIKV-IN-1
|
Others | Others |
ZIKV-IN-1 是一种 zika virus 的有效抑制剂 (EC50: 2.8 μM, EC90: 6.8 μM)。ZIKV-IN-1 具有抗 ZIKV 作用,且细胞毒性低。ZIKV-IN-1 对 ZIKV RdRp 结构域表现出很高的亲和力。 | |||
T82957 |
ASN 07115873
|
Others | Others |
ASN 07115873为具有显著抗ZIKV活性的化合物,其半抑制浓度(IC50)为189.2 pM,适用于抗病毒研究领域。 | |||
T78618 |
NSC 288387
|
Virus Protease | Microbiology/Virology |
NSC 288387是泛黄病毒MTase的抑制剂,能与SAM结合袋发生作用。该化合物对ZIKV表现出抑制活性,IC50值为0.2 μM,并能够抑制细胞培养中的病毒复制。 | |||
T73156 |
LabMol-301
|
Others | Others |
LabMol-301 抑制NS5 RdRp 和NS2B-NS3pro 的活性 (IC50分别为 0.8 和 7.4 μM)。LabMol-301 具有细胞保护作用并阻止寨卡病毒 (ZIKV) 诱导的细胞死亡。 | |||
T63495 |
CYP2C1/CYP2C19-IN-2
|
Others | Others |
CYP2C1/CYP2C19-IN-2 是无肝脏毒性和遗传毒性的CYP2C9/CYP2C19强效抑制剂,能够用于研究寨卡病毒 (ZIKV) 感染。 | |||
T63496 |
CYP2C9/CYP2C19-IN-1
|
Others | Others |
CYP2C9/CYP2C19-IN-1 是无肝脏毒性和遗传毒性的CYP2C9/CYP2C19强效抑制剂,能够用于研究寨卡病毒 (ZIKV) 感染。 | |||
T81641 |
NS2B-NS3pro-IN-2
|
Virus Protease | Microbiology/Virology |
NS2B-NS3pro-IN-2是针对寨卡病毒NS2B-NS3蛋白酶的抑制剂,展示了在50μM浓度时的抗病毒特性。 | |||
T21978 |
p-nitro-Pifithrin-α
|
Others | Others |
p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α, a potent p53 inhibitor. It suppresses p53-mediated TGF-β1 expression in HK-2 cells and inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. Moreover, p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice subjected to a high-fat diet, mitigating the effects of non-alcoholic fatty liver disease [1] [2] [3] [4]. | |||
T64067 |
ZIKV-IN-2
|
Others | Others |
ZIKV-IN-2 是 ZIKV NS5 甲基转移酶 (MTase) 的有效抑制剂 (IC50: 38.86 μM),可以抑制 ZIKV 的复制和感染。ZIKV-IN-2 能够用于研究寨卡病毒 (ZIKV)。 | |||
T70941 |
CLR01 sodium
|
Others | Others |
CLR01 is a molecular tweezer. CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy. CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro and in the G93A-SOD1 mouse model of ALS. CLR01 inhibits Ebola and Zika virus infection. CLR01 Stabilizes a Disordered Protein-Protein Interface. CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity. | |||
T63337 |
CYP2C19-IN-1
|
Others | Others |
CYP2C19-IN-1 是强效的,无遗传毒性的、无肝脏毒性的 CYP2C19 抑制剂。 CYP2C19-IN-1 能够抑制 RNA 依赖的 RNA 聚合酶 (RdRP) (Ki: 6.16 μM),能够用于研究寨卡病毒 (ZIKV) 感染。 | |||
T82592 |
DEC-RVRK-CMK
Decanoyl-Arg-Val-Arg-Lys-chloromethylketone |
||
DEC-RVRK-CMK为一种小型合成抗病毒化合物,具不可逆性及细胞渗透性,作为竞争性弗林蛋白酶抑制剂,该化合物对寨卡病毒(ZIKV)和日本脑炎病毒(JEV)显示出显著的抗病毒活性。 | |||
T80729 |
ZIKV-IN-6
|
Others | Others |
ZIKV-IN-6(化合物22)是一种针对寨卡病毒(ZIKV)的抑制剂,显示出低细胞毒性(CC50>50 μM)。该化合物能够直接结合至ZIKV RdRp,进而抑制ZIKV NS5的病毒RNA合成功能,并能够抑制过度炎症反应以及细胞的焦亡(pyroptosis)。 | |||
T79334 |
Antiviral agent 36
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Antiviralagent 36 (compound 27) 作为一种抗病毒化合物,对登革热病毒(DENV)和寨卡病毒(ZIKV)展现出高效的抑制作用。通过抑制这两种病毒的复制,Antiviralagent 36 对ZIKV-FLR、ZIKV-HN16、DENV-2和DENV-3的半数抑制浓度(EC50)分别达到100 nM、90 nM、210 nM和120 nM,表明其具有较强的抗病毒活性。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3S1852 |
Cephaeline hydrochloride
|
Others; Virus Protease; Influenza Virus | Microbiology/Virology; Others |
Cephaeline hydrochloride 是 Indian Ipecac 中的一种酚类生物碱。它有效抑制病毒 ZIKV 和 EBOV 感染。 | |||
TN1480 |
Cephaeline
吐根鹼,吐根酚碱 |
Virus Protease; Influenza Virus; HIF | Angiogenesis; Chromatin/Epigenetic; Microbiology/Virology |
Cephaeline 对受保护的原代 CLL 细胞具有高度活性(相对 IC50 为 35nM),并通过抑制 HIF-1α± 和扰乱细胞内氧化还原稳态发挥作用。 | |||
T8504 |
Dianemycin
Nanchangmycin (free acid) |
Antibacterial; Antibiotic | Microbiology/Virology |
Dianemycin (Nanchangmycin (free acid)) 由Streptomyces nanchangensis 产生的一种聚醚抗生素,抑制革兰氏阳性菌。它也是一种针对 Zika 病毒的广谱抗病毒药物。 | |||
T3366 |
Cephalotaxine
ZINC19795976,三尖杉碱,(-)-Cephalotaxine,Cephalotaxlen |
Antiviral; Influenza Virus | Immunology/Inflammation; Microbiology/Virology |
Cephalotaxine (ZINC19795976) 是从头孢紫杉中分离得到的一种生物碱,具有抗白血病和抗病毒活性,如抗 Zika 病毒。 | |||
T80768 |
XA-E
Xanthoangelol E |
Others | Others |
XA-E是一种从A. keiskei中提取并通过甲醇-乙酸乙酯纯化得到的化合物。该化合物展现出对ZIKV(Zika病毒)的抗活性,其半抑制浓度(IC50)为22.0 µM。 | |||
T80002 |
Wulfenioidin F
|
Virus Protease | Microbiology/Virology |
Wulfenioidin F是从Orthosiphon wulfenioides全草分离的二萜类化合物。该化合物对抗寨卡病毒(ZIKV)活性显著,其半数有效浓度(EC50)为8.07 μM。Wulfenioidin F的抗病毒机制通过抑制ZIKV包膜(E)蛋白的表达,从而干扰病毒复制。 | |||
T80003 |
Wulfenioidin H
|
Others | Others |
Wulfenioidin H (Compound 5) 是二萜类化合物,对抗寨卡病毒(ZIKV)活性显著,其EC50为 8.50 μM。该化合物能够通过抑制ZIKV包膜(E)蛋白表达来干预病毒复制。 | |||
T6601 |
Nanchangmycin
Nanchangmycin A,南昌霉素 |
Antibacterial; Antibiotic | Microbiology/Virology |
Nanchangmycin (Nanchangmycin A) 由 Streptomyces nanchangensis 产生的一种聚醚抗生素,抑制革兰氏阳性菌。它也是一种广谱抗病毒药物,有抗 Zika 病毒作用。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-04892 |
Zika virus (ZIKV) (strain Zika SPH2015) E/Envelope protein (His)
|
ZIKV | Baculovirus Insect Cells |
Zika virus (ZIKV) (strain Zika SPH2015) E/Envelope protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 45.5 kDa and the accession number is ALU33341.1. | |||
TMPY-04870 |
Zika virus (ZIKV) (strain Zika SPH2015) ZIKV-NS1 protein (His)
|
ZIKV | HEK293 Cells |
Zika virus NS1 antigen is one of seven non-structural proteins. NS1 is involved in RNA replication. The possible effects of NS1 on hosts include: localizes to host cell surface and secreted extracellularly, modulates signalling of the innate immune system, has possible damages to platelets and endothelial cells through anti-NS1 antibodies. | |||
TMPY-05310 |
Zika virus (strain Zika SPH2015) E/Envelope protein (His & MBP)
|
ZIKV | E. coli |
Zika virus (strain Zika SPH2015) E/Envelope protein (His & MBP) is expressed in E. coli expression system with His and MBP tag. The predicted molecular weight is 57.2 kDa and the accession number is ALU33341.1. | |||
TMPY-04895 |
Zika virus (strain Zika SPH2015) E/Envelope protein (His)
|
ZIKV | P. pastoris (Yeast) |
Zika virus (strain Zika SPH2015) E/Envelope protein (His) is expressed in yeast with His tag. The predicted molecular weight is 12.9 kDa and the accession number is ALU33341.1. | |||
TMPY-05024 |
Zika virus (ZIKV) (strain Zika SPH2015) ZIKV-NS5 protein (His)
|
ZIKV | Baculovirus Insect Cells |
Zika virus NS5 is involved in methytransferase and RNA guanylytransferase activities and capping and synthesis of RNA. And, NS5 is also an RNA-dependent RNA polymerase. | |||
TMPY-04904 |
Zika virus (ZIKV) (strain Zika SPH2015) M/Membrane protein (Fc)
|
ZIKV | HEK293 Cells |
Zika virus (ZIKV) infection causes microcephaly and has been linked to other brain abnormalities. ZIKV has a more selective and larger impact on the expression of genes involved in DNA replication and repair. P53 inhibitors can block the apoptosis induced by ZIKV-M in hNPCs. | |||
TMPY-04869 |
Zika virus (ZIKV) (strain Zika SPH2015) ZIKV-E/Envelope protein (Fc)
|
ZIKV | HEK293 Cells |
Zika virus (ZIKV) (strain Zika SPH2015) ZIKV-E/Envelope protein (Fc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 38.2 kDa and the accession number is ALU33341.1. | |||
TMPY-04868 |
Zika virus (ZIKV) (strain Zika SPH2015) ZIKV-E/Envelope protein (His)
|
ZIKV | HEK293 Cells |
Zika virus (ZIKV) (strain Zika SPH2015) ZIKV-E/Envelope protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13 kDa and the accession number is ALU33341.1. | |||
TMPY-05709 |
Zika virus (ZIKV) (strain Zika SPH2015) ZIKV-E/Envelope protein (His), Biotinylated
|
ZIKV | HEK293 Cells |
Zika virus (ZIKV) (strain Zika SPH2015) ZIKV-E/Envelope protein (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13 kDa and the accession number is ALU33341.1. | |||
TMPY-05331 |
Zika virus (ZIKV) (strain Zika SPH2015) E/Envelope protein (aa 291-696, His)
|
ZIKV | Baculovirus Insect Cells |
Zika virus (ZIKV) (strain Zika SPH2015) E/Envelope protein (aa 291-696, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 45.6 kDa and the accession number is ALU33341.1. | |||
TMPY-04905 |
Zika virus (ZIKV) (strain Zika SPH2016) ZIKV-E (Stem/anchor domain of flavivirus envelope glycoprotein E) protein (Fc)
|
ZIKV | HEK293 Cells |
Zika virus (ZIKV) (strain Zika SPH2016) ZIKV-E (Stem/anchor domain of flavivirus envelope glycoprotein E) protein (Fc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 36.7 kDa and the accession number is ALU33341.1. |