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Search Results for " yap1 "

Targets Recommended: YAP

3

抑制剂 & 化合物

8

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T8421	TED-347	YAP	Stem Cells
	TED-347 是不可逆的、共价的 YAP-TEAD 蛋白质-蛋白质相互作用变构抑制剂，对 TEAD4•Yap1 蛋白质-蛋白质相互作用的 EC50为 5.9 μM。它与 TEAD4 中央口袋内的 Cys-367 特异性共价结合(Ki:10.3 μM)。它可以抑制 TEAD 的转录活性，并且具有抗肿瘤作用。
T9954	K-975	Others	Others
	K-975是一种高选择性的具有口服活性的TEAD 抑制剂，可有效抑制TEAD 和YAP1/TAZ 之间的蛋白质-蛋白质相互作用。
T79687	TEAD-IN-6	YAP	Stem Cells
	TEAD-IN-6（Example 11-1），一种TEAD调节剂，具有阻断YAP1/TAZ与TEAD相互作用的活性，适用于癌症研究领域。

化合物

Cat.No: T8421

Target: YAP

Cat.No: T9954

Target: Others

Cat.No: T79687

Target: YAP

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00005	YAP1 Protein, Human, Recombinant (Isoform 9, His) Protein yorkie homolog,YAP1,Yes-associated...	Human	P. pastoris (Yeast)
	YAP1 Protein, Human, Recombinant (Isoform 9, His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 56.4 kDa; 80 kDa, reducing conditions and the accession number is P46937-9.
TMPH-03764	YAP1 Protein, Human, Recombinant (His) YAP1-2gamma,YAP2L,YAP65	Human	P. pastoris (Yeast)
	Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1,...
TMPY-06815	SYAP1 Protein, Human, Recombinant (His) PRO3113,synapse associated protein 1	Human	Baculovirus Insect Cells
	Synapse-associated protein 1 (SYAP1), also known as PRO3113 and BSTA, belongs to the synapse-associated BSD domain family, featuring three α-helices and two conserved tryptophan and phenylalanine residues located at the C-terminus. Expressed near neuronal Golgi and synaptic regions of cerebellar Purkinje cells, SYAP1 has been linked to intact sensorimotor control and general vesicular trafficking in neurons. SYAP1-deficient mice display impaired locomotor activity. In cultured adipocytes, SYAP1 ...
TMPY-02648	PACAP receptor/ADCYAP1R1 Protein, Human, Recombinant (hFc) adenylate cyclase activating polypeptide 1 (pituita...	Human	HEK293 Cells
	Pituitary adenylate cyclase activating polypeptide (PACAP, Adcyap1) activation of PAC1 receptors ( Adcyap1r1) significantly increases excitability of guinea pig cardiac neurons. This modulation of excitability is mediated in part by plasma membrane G protein-dependent activation of adenylyl cyclase and downstream signaling cascades. Studies point to the potential role of the (pituitary) adenylate cyclase activating polypeptide receptor 1 (ADCYAP1R1) gene, which has been implicated in stress resp...
TMPH-02226	TEAD3 Protein, Human, Recombinant (His & SUMO) DTEF-1,TEA domain family member 3,Transcriptional e...	Human	E. coli
	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expr...
TMPH-02225	TEAD2 Protein, Human, Recombinant (His & Myc) TEA domain family member 2,Transcriptional enhancer factor T...	Human	E. coli
	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expr...
TMPH-02222	TEAD1 Protein, Human, Recombinant (His) TEAD1,Transcriptional enhancer factor TEF-1	Human	E. coli
	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expr...
TMPJ-01260	WBP2 Protein, Human, Recombinant (His) WBP2,WW Domain-Binding Protein 2,WBP-2	Human	E. coli
	WW Domain-Binding Protein 2 (WBP2) is a ubiquitous protein that contains one GRAM domain. The WW domain is composed of 38 to 40 semi-conserved AA shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is participated in mediating protein-protein interactions. WBP2 binds to the WW domain of YAP1, WWP1 and WWP2. The WW-binding 1 motif of WBP2 mediates interaction with NEDD4. The function of this protein WBP2 has not been determined. Some resear...

重组蛋白

YAP1 Protein, Human, Recombinant (Isoform 9, His)

Cat.No: TMPH-00005

Species: Human

Expression System: P. pastoris (Yeast)

YAP1 Protein, Human, Recombinant (His)

Cat.No: TMPH-03764

Species: Human

Expression System: P. pastoris (Yeast)

SYAP1 Protein, Human, Recombinant (His)

Cat.No: TMPY-06815

Species: Human

Expression System: Baculovirus Insect Cells

PACAP receptor/ADCYAP1R1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-02648

Species: Human

Expression System: HEK293 Cells

TEAD3 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02226

Species: Human

Expression System: E. coli

TEAD2 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02225

Species: Human

Expression System: E. coli

TEAD1 Protein, Human, Recombinant (His)

Cat.No: TMPH-02222

Species: Human

Expression System: E. coli

WBP2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01260

Species: Human

Expression System: E. coli

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