68
4
14
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T80498 |
Jingzhaotoxin-XII
JzTx-XII |
Potassium Channel | Membrane transporter/Ion channel |
Jingzhaotoxin-XII (JzTx-XII) 作为特异性 Kv4.1 通道抑制剂,表现出 0.363 μM 的 IC50 值,通过改变通道的门控行为来与其相互作用。 | |||
T21949 |
Calpain Inhibitor XII
|
Others | Others |
(Rac)-Calpain Inhibitor XII是一种可逆的,选择性抑制钙蛋白酶I(calpain I; μ-calpain)的化合物,具有19 nM的Ki值。其对钙蛋白酶II(calpain II; m-calpain; Ki=120 nM)和组织蛋白酶B(cathepsin B; Ki=750 nM)显示出较低的抑制亲和力。(Rac)-Calpain Inhibitor XII用于研究钙蛋白酶在多种生理过程中的角色,如嗜中性粒细胞趋化性、神经元信号传导和心脏对损伤的响应。 | |||
T125110 |
Eupteleasaponin XII
|
Others | Others |
Eupteleasaponin XII 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T125110,CAS号为 290809-58-4。 | |||
T125868 |
RA-XII
|
Others | Others |
RA-XII 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T125868,CAS号为 143343-98-0。 | |||
T17281 |
Z-Ile-Leu-aldehyde
Z-IL-CHO,GSI-XII,γ-Secretase inhibitor XII |
Others | Others |
Z-Ile-Leu-aldehyde is an effective and competitive peptide aldehyde inhibitor of γ-secretase and notch. | |||
T79753 |
hCAIX/XII-IN-8
|
Carbonic Anhydrase | Metabolism |
hCAIX/XII-IN-8(compound 3g)是一种对人类(碳酸酐酶)CA IX和XII高效的抑制剂,Ki值分别为8.5和6.7 nM。该化合物对与肿瘤相关的膜结合异构体hCA IX和XII表现出显著的抑制作用,且相对于胞内异构体hCA I和II具有较高的选择性。 | |||
T61384 |
hCAIX/XII-IN-4
|
Others | Others |
hCAIX/XII-IN-4 (compound 6c) is a highly potent inhibitor of CAIX/XII. It exhibits Ki values of 4.5 nM, 23.6 nM, >10000 nM, and >10000 nM for CAXII, CAIX, CAI, and CAⅡ, respectively [1]. | |||
T72840 |
hCAIX/XII-IN-6
|
Others | Others |
hCAIX/XII-IN-6 是具有口服活性的碳酸酐酶(CA)抑制剂,能够抑制人体 CA 亚型 hCA I、II、IV、IX 及 XII,其 Ki 值分别为 6697 nM、2950 nM、4093 nM、4.1 nM 和 7.7 nM。适用于类风湿关节炎(RA)研究。 | |||
T25779 |
MDK-4683
MDK 4683,CA IX/XII Inhibitor |
Others | Others |
MDK-4683, also known as CA IX/XII Inhibitor, is a hCA IX and hCA XII inhibitor. | |||
T63400 |
hA2A/hCA XII modulator 1
|
Others | Others |
hA2A/hCA XII modulator 1 是 hA2A 腺苷受体 (hA2AAR) 的有效拮抗剂,是一种三唑并吡嗪, 能够作用于hA2AAR (Ki: 6.4 nM)、hA1AR (Ki: 4.819 μM)、hA3AR (Ki>30 μM)。hA2A/hCA XII modulator 1 也人碳酸酐酶 XII (hCA XII) 的有效抑制剂,能够作用于 hCA XII (Ki: 6.2 nM)、hCA II (Ki: 46 nM)、hCA IX (Ki: 466 nM) 和 hCA I (Ki: 8.351 μM)。hA2A/hCA XII modulator 1 表现出研究癌症的潜力。 | |||
T79748 |
hCAIX/XII-IN-7
|
Carbonic Anhydrase | Metabolism |
hCAIX/XII-IN-7(compound 3e)为高效的hCA IX与XII抑制剂,对hCA I、II、IX与XII的Ki值分别为3.2 nM、9.2 nM、503.7 nM及59 nM,显示其在缺氧肿瘤研究中的应用潜力。 | |||
T60602 |
hCAIX/XII-IN-5
|
Others | Others |
hCAIX/XII-IN-5 (Coumarin 9a) 是一种碳酸酐酶 (CA) 抑制剂,具有出色的 hCA IX/XII 选择性,对 hCA I 和 hCA II 的Ki 值分别为 93.9 和 85.7 nM。hCAIX/XII-IN-5 对癌细胞具有抗增殖活性,可延迟细胞周期并诱导细胞凋亡。 | |||
T61015 |
hCAIX/XII-IN-2
|
Others | Others |
hCAIX/XII-IN-2 (compound 6a) 是有效的 hCAIX 和 hCAXII 的选择性抑制剂,其对于hCAI、hCAII、hCAIX 和 hCAXII 的Ki 值分别为 >10000、>10000、30.0、3.6 nM。 | |||
T78789 |
hCA XII-IN-6
|
Carbonic Anhydrase | Metabolism |
hCA XII-IN-6(化合物4d)是一种具有84.2 nM Ki值的hCA XII强效抑制剂,显示出抗增殖活性,并可用于癌症的研究。 | |||
T61959 |
hCAIX/XII-IN-3
|
Others | Others |
hCAIX/XII-IN-3 (compound 6q) 是一种有效的、选择性的 hCAIX 和 hCAXII 抑制剂。hCAIX/XII-IN-3抑制 hCAI、hCAII、hCAIX 和 hCAXII 的 Ki 值分别为 >10000、>10000、66.2、4.4 nM。 | |||
T61873 |
hCAIX/XII-IN-1
|
Others | Others |
hCAIX/XII-IN-1 是一种有效的CAIX/XII 抑制剂,KI 值分别为 0.48 μM 和 0.83 μM。hCAIX/XII-IN-1 显示出体外抗增殖活性。hCAIX/XII-IN-1 诱导 MCF-7 细胞凋亡apoptosis。 | |||
T79351 |
JH-XII-03-02
|
PROTACs | PROTAC |
JH-XII-03-02为高效的选择性LRRK2 PROTAC降解剂,适用于帕金森病相关研究。 | |||
T63764 |
hCA XII/II/IX-IN-1
|
Others | Others |
hCA XII/II/IX-IN-1 是人碳酸酐酶 (hCA) 的有效抑制剂,能够作用于 hCA I (IC50: 2.6 μM)、 hCA II (IC50: 0.004 μM)、hCA IX (IC50: 0.005 μM) 和 hCA XII (IC50: 0.001 μM)。hCA XII/II/IX-IN-1 表现出抗癌效果。 | |||
T4502 |
BISMUTH SUBGALLATE
次没食子酸铋,Dermatol Puder,Bismuth Gallate |
Others | Others |
Bismuth subgallate (Dermatol Puder) 是一种止血剂,可作用于凝血因子 XII ,促使凝血级联的激活,改善纤维蛋白凝块的早期形成。 | |||
T36758 |
CAIX Inhibitor S4
S4 |
Carbonic Anhydrase | Metabolism |
CAIX Inhibitor S4 (S4) 是一种有效的碳酸酐酶 IX/XII 抑制剂,Ki 分别为 7 nM 和 2 nM。 CA II 和 CA I 的 Ki 分别为 546 和 5600 nM。 | |||
T78578 |
GSK-3 Inhibitor XIII
|
GSK-3 | PI3K/Akt/mTOR signaling; Stem Cells |
GSK-3 Inhibitor XIII,一种ATP竞争性的 GSK-3抑制剂(Ki:24 nM),可用于研究糖尿病和肥胖。 | |||
T24111 |
GSK3i XIII
GSK3 inhibitor XIII,GSK3iXIII,GSK3i-XIII |
GSK-3 | PI3K/Akt/mTOR signaling; Stem Cells |
GSK3i XIII (GSK3 inhibitor XIII) 是ATP 竞争性GSK-3抑制剂(Ki: 24 nM)。 | |||
T63276 |
hCAXII-IN-4
|
Others | Others |
hCAXII-IN-4 是选择性的、有效的 CA XII 抑制剂,对人CA XII 的Ki 值为 6.4 nM。 | |||
T62101 |
hCAXII-IN-2
|
Others | Others |
hCAXII-IN-2 (compound 5i) 是一种人碳酸酐酶 XII (hCA XII) (Ki: 84.2 nM) 和 hCA IX (Ki: 268.5 nM) 的有效抑制剂,对 hCA I 和 hCA II 具有较低的活性。 | |||
T79411 |
hCAXII-IN-7
|
Carbonic Anhydrase | Metabolism |
hCAXII-IN-7 (compound 6e)为hCA XII抑制剂,且具备脑屏障通透性。此化合物能够诱导786-0、SF-539和HS 578 T细胞系的凋亡。 | |||
T61219 |
hCAXII-IN-1
|
Others | Others |
hCAXII-IN-1 demonstrates selective inhibition of tumor-related subtypes HCA IX and XII, making it potential leading molecules in the development of novel cancer therapeutic drugs with new mechanisms of action. | |||
T60930 |
CAXII-IN-1
|
Others | Others |
CAXII-IN-1 (Compound 17) 具有抗肿瘤活性,它是 CA XII 的选择性抑制剂。CAXII-IN-1 对 hCA XII 和 hCA IX 的 Ki 值分别为 3.8 nM 和 56.0 nM。 | |||
T63973 |
hCAXII-IN-3
|
Others | Others |
hCAXII-IN-3 (Compound 6o) 是人碳酸酐酶 XII(hCAXII)的选择性抑制剂 (Ki: 10.0 nM)。 | |||
T82361 |
FXIIa-IN-1
|
Others | Others |
XIIa-IN-1-IN-3(Compound 22)作为一种Factor XIIa抑制剂,其Kiapp值为97.8 nM。该化合物主要应用于血栓形成的研究。 | |||
T82360 |
FXIIa-IN-2
|
Others | Others |
XIIa-IN-1-IN-2(Compound 21)为一种高效的Factor XIIa抑制剂,具有Kiapp为62.2 nM。该化合物适用于血栓形成的研究领域。 | |||
T80485 |
μ-Conotoxin SxIIIC
|
Sodium Channel | Membrane transporter/Ion channel |
μ-Conotoxin SxIIIC是从条纹芋螺(Conus striolatus)提取的不可逆NaV通道(NaV channel)抑制剂,适用于慢性疼痛等神经系统疾病研究。 | |||
T82727 |
Chromoionophore XIII
SNARF-DE |
||
Chromoionophore XIII (SNARF-DE)是一种可用红光激发的pH传感器。其功能质使指示剂分子具有亲脂性而不溶于水,并且能抑制该染料在极性环境下发生内酯化反应。 | |||
T61769 |
hCAXII-IN-5
|
Others | Others |
hCAXII-IN-5 (compound 6o) is a highly effective and specific inhibitor of hCAXII. The compound exhibits impressive binding affinities, with Ki values of >10000, >10000, 286.1, and 1.0 nM for hCAI, hCAII, hCAIX, and hCAXII, respectively [1]. | |||
T2017 |
U-104
NSC-213841,MST-104 |
Carbonic Anhydrase | Metabolism |
U-104 (NSC-213841) 是 CA IX 和 CA XII 碳酸酐酶 (CA) 抑制剂,其 Ki 分别为 45.1 nM 和 4.5 nM。小鼠模型中,它能够表现出明显的抑制肿瘤生长的作用。 | |||
T73177 |
hCAII-IN-9
|
Carbonic Anhydrase | Metabolism |
hCAII-IN-9 是一种强效的碳酸酐酶抑制剂,对hCA II、hCA IX 和hCA XII 有抑制作用,IC50 分别为 1.18 μM 和 0.17 μM , and 2.99 μM 。hCAII-IN-9 没有血脑屏障透过性。 | |||
T77018 |
Garadacimab
CSL312 |
Factor Xa | Metabolism |
Garadacimab (CSL312) 是有效的全人 IgG4 单克隆抗体,针对活化因子 XII (FXIIa)。Garadacimab 可用于研究遗传性血管性水肿。 。 | |||
T63305 |
Carbonic anhydrase inhibitor 6
|
Carbonic Anhydrase | Metabolism |
Carbonic anhydrase inhibitor 6 是一种高效的人碳酸酐酶 (hCA) 抑制剂,抑制 hCA IX,hCA II,hCA XII和hCA I,可用于研究碳酸酐酶异常引起的疾病。 | |||
T77631 |
Enpp/Carbonic anhydrase-IN-2
|
Apoptosis; PDE; Carbonic Anhydrase | Apoptosis; Metabolism |
Enpp/Carbonic anhydrase-IN-2 is a potent dual inhibitor of Enpp and carbonic anhydrase, inhibiting NPP1, NPP2, NPP3, CA-IX, CA-XII, with IC50 values of 1.13, 1.07, 0.74, 0.33, 0.68, respectively.Enpp/Carbonic anhydrase-IN-2 induced apoptosis.Enpp/Carbonic anhydrase-IN-2 has antiproliferative activity against cancer cells and low cytotoxicity against normal cells. | |||
T61745 |
hCAI/II-IN-6
|
Carbonic Anhydrase | Metabolism |
hCAI/II-IN-6 是一种具有选择性和口服活性的human carbonic anhydrase(CA) 抑制剂。hCAI/II-IN-6对 hCA I,hCA II,hCA VII 和 hCA XII 有抑制作用,Ki 值分别为 220,4.9,6.5 和 >50000 nM。hCAI/II-IN-6 在体内显示抗惊厥活性。hCAI/II-IN-6 可以用于研究癫痫。 | |||
PDK0269 |
1-Phenylbiguanide HCl
Phenylbiguanide hydrochloride |
Others | Others |
Compound PDK0269作为5-HT3受体激动剂(3-100 μM, pEC50 5.05±0.06),可急性增加XII(舌下)发作频率和规律性,并降低发作/次。Phenylbiguanide 产生剂量依赖性(10-500 μM)的多巴胺释放增加(280-2000%)。当Ringer 溶液中加入5 μM 的 nomifensine 时,Compound PDK0269对多巴胺释放的影响得到改善或抑制。 | |||
T30909 |
Chromozym PK
|
Others | Others |
Chromozym PK is a chromogenic substrate for factor XII assay. | |||
T62026 |
hCAIX-IN-11
|
Others | Others |
hCAIX-IN-11 (Compound 5d) 是选择性的碳酸酐酶 (carbonic anhydrase) IX 和 XII 抑制剂。hCAIX-IN-11抑制 hCA IX 和 hCA XII 的Ki 分别为 32.7 和 623.5 nM。 | |||
T63158 |
hCAIX-IN-10
|
Others | Others |
hCAIX-IN-10 (Compound 6i) 是一种选择性碳酸酐酶 IX 和 XII 抑制剂,作用于 hCA IX (Ki: 61.5 nM) 和 hCA XII (Ki: 586.8 nM)。其中 hCA IX 和 hCA XII 是一种跨膜同工型碳酸酐酶,能够作为一些类型肿瘤的生物标志物。hCA XII 有助于正常细胞和肿瘤细胞中酸碱平衡的维持。 | |||
T62666 |
Carbonic anhydrase inhibitor 7
|
Others | Others |
Carbonic anhydrase inhibitor 7 是一种人碳酸酐酶 (hCA) 的有效抑制剂,作用于 hCA IX (Ki: 6.5 nM),hCA II (Ki: 7.1 nM),hCA XII (Ki: 72.1 nM) 和 hCA I (Ki: 255.8 nM)。 | |||
T79540 |
hCA/VEGFR-2-IN-1
|
Carbonic Anhydrase | Metabolism |
hCA/VEGFR-2-IN-1 是一种高效的双靶点抑制剂,对 hCA IX 和 hCA XII 两种碳酸酐酶(CA)具有极低的Ki值,分别为8.3 nM和4.7 nM。同时,hCA/VEGFR-2-IN-1 也是一种有效的 VEGFR-2 抑制剂,其 IC50 值仅为26.3 nM,并且显示出抗癌活性。 | |||
TP1866 |
β-Amyloid (1-11)
β-amyloid 1-11 |
||
Anionic interaction of Beta-amyloid (1-11) with Factor XII is suspected to cause massive activation of the C4 (complement 4) system in the cerebrospinal fluid of Alzheimer’s disease patients. | |||
T62976 |
Carbonic anhydrase inhibitor 5
|
Others | Others |
Carbonic anhydrase inhibitor 5 是一种有效的、选择性的人碳酸酐酶 (hCA) 抑制剂,能够作用于 hCA II (IC50: 42.9 nM)、hCA IX (IC50: 47.6 nM) 和 hCA XII (IC50: 6.7 nM)。 | |||
T63005 |
Carbonic anhydrase inhibitor 11
|
Others | Others |
Carbonic anhydrase inhibitor 11 (compound VI) 是一种有效的、选择性碳酸酐酶抑制剂,能够作用于 CA II (Ki: 40 nM)、CA IX (Ki: 39 nM) 和 CA XII (Ki: 900 nM)。 | |||
T79588 |
hCA/VEGFR-2-IN-3
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
hCA/VEGFR-2-IN-3(compound 8j)是一种吲哚酮基苯磺酰胺类化合物,作为hCA IX/XII和VEGFR-2的双重抑制剂,在抗癌领域具有潜在应用。该化合物对VEGFR-2表现出显著的抑制活性(IC50=358 nM),并且与hCAs有较高的亲和力,具体活性为:Ki值分别为4.2 nM(hCA IX),22.9 nM(hCA II),25.1 nM(hCA I)和28.0 nM(hCA XII)。此外,hCA/VEGFR-2-IN-3还对过表达VEGFR-2的乳腺癌细胞显示出抗增殖效果。 | |||
T80095 |
D-Pro-Phe-Arg-Chloromethylketone
|
Factor Xa | Metabolism |
D-Pro-Phe-Arg-Chloromethylketone是一种抑制剂,它针对凝血因子XII (coagulation factor XII) 和血浆激肽释放酶 (kallikrein),在血栓形成和炎症过程中具有关键作用。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13717 |
Gypenoside XIII
|
Others | Others |
Gypenoside XIII is belonging to the gypenosides. Gypenosides, extracted from Gynostemma pentaphyllum, protect against cardiovascular diseases, especially atherosclerosis. | |||
T82806 |
Bupleuroside XIII
|
||
Bupleuroside XIII为具有肝脏保护作用的天然皂苷。 | |||
T0465 |
Ellagic acid
鞣花酸,Gallogen,Elagostasine |
Hedgehog/Smoothened; Casein Kinase; Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; PKA; Syk; PKC; Carbonic Anhydrase | Angiogenesis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors |
Ellagic acid (Gallogen) 是从 Eucalyptus maculata Hook 和 E. Hemipholia F. Muell 的 kino 中分离出来的稠合四环天然产物,是一种有效的,ATP 竞争性的CK2抑制剂,IC50和Ki 值分别为 40 nM 和 20 nM。 | |||
T40611 |
(E)-Dehydrodiconiferyl alcohol
|
Others | Others |
(E)-Dehydrodiconiferyl alcohol is a potent dual inhibitor of hCA IX and hCA XII, effectively impeding the catalytic activity of both carbonic anhydrase isoforms. Additionally, (E)-Dehydrodiconiferyl alcohol exerts inhibitory effects on the nuclear translocation of NF-κB in the connective tissue of the healing area. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00694 |
Carbonic Anhydrase 12 Protein, Human, Recombinant (His)
HsT18816,FLJ20151,carbonic anhydrase XII,CA12,CA |
Human | HEK293 Cells |
Carbonic Anhydrase 12 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.6 kDa and the accession number is O43570-1. | |||
TMPH-03106 |
Coagulation factor XII Protein, Pig, Recombinant (His)
HAF,Hageman factor,F12,Coagulation factor XII |
Sus scrofa (Pig) | E. coli |
Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. Coagulation factor XII Protein, Pig, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predic... | |||
TMPY-00688 |
Carbonic Anhydrase 12 Protein, Mouse, Recombinant (His)
AI314958,Car12,2310047E01Rik,carbonic anhydrase XII |
Mouse | HEK293 Cells |
Carbonic Anhydrase 12 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.8 kDa and the accession number is Q8CI85. | |||
TMPH-01114 |
COL12A1 Protein, Human, Recombinant (His)
Collagen alpha-1(XII) chain,COL12A1L,COL12A1 |
Human | E. coli |
COL12A1 Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-03383 |
Synaptotagmin-12 Protein, Rat, Recombinant (His)
Syt12,Synaptotagmin-12,Synaptotagmin XII,Synaptotag... |
Rat | E. coli |
Synaptic vesicle phosphoprotein that enhances spontaneous neurotransmitter release but does not effect induced neurotransmitter release. Unlike other synaptotagmins, it does not bind Ca(2+) or phospholipids. Essential for mossy-fiber long-term potentiation in the hippocampus. Synaptotagmin-12 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 50.7 kDa and the accession number is P97610. | |||
TMPH-02588 |
COL12A1 Protein, Mouse, Recombinant (His)
Collagen alpha-1(XII) chain,COL12A1L,COL12A1 |
Mouse | E. coli |
Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix. | |||
TMPY-06944 |
Carbonic Anhydrase 12 Protein, Human, Recombinant (His & Avi), Biotinylated
HsT18816,carbonic anhydrase XII,CAXII,FLJ2... |
Human | HEK293 Cells |
Carbonic Anhydrase 12 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 33.45 kDa and the accession number is NP_001209.1. | |||
TMPK-00478 |
Carbonic Anhydrase 12 Protein, Cynomolgus, Recombinant (His)
CA12,CAXII,Carbonic anhydrase,CA-XII,Tumor... |
Cynomolgus | HEK293 Cells |
Carbonic anhydrases (CAs) are a family of enzymes involved in the pH regulation of metabolically active cells/tissues. Carbonic anhydrase XII (CA XII) is a key mediator of several signaling pathways that are involved in cancer development. | |||
TMPY-02185 |
Coagulation factor XIII B/F13B Protein, Human, Recombinant (His)
Coagulation factor 13,coagulation factor XIII, B po... |
Human | HEK293 Cells |
Coagulation factor XIII B chain, also known as Fibrin-stabilizing factor B subunit, Protein-glutamine gamma-glutamyltransferase B chain, Transglutaminase B chain and F13B, is a secreted protein which contains 1 Sushi ( CCP / SCR ) domains. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have en... | |||
TMPH-00051 |
Chitin deacetylase Protein, Amylomyces rouxii, Recombinant (His)
Chitin deacetylase,MrCDA,CDA |
Amylomyces rouxii | E. coli |
Hydrolyzes the N-acetamido groups of N-acetyl-D-glucosamine residues in chitin to form chitosan and acetate. Chitin deacetylase Protein, Amylomyces rouxii, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 49.9 kDa and the accession number is P50325. | |||
TMPH-00430 |
VxXIIC Protein, Conus vexillum, Recombinant (His & Myc & SUMO)
Alpha-conotoxin VxXXC,VxXIIC |
Conus vexillum | E. coli |
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin specifically blocks mammalian neuronal nAChR of the alpha-7/CHRNA7, alpha-3-beta-2/CHRNA3-CHRNB2 and alpha-4-beta-2/CHRNA4-CHRNB2 subtypes. VxXXA and VxXXB inhibit alpha-7/CHRNA7 and alpha-3-beta-2/CHRNA3-CHRNB2 nAChR more efficiently than VxXXC. VxXXB is the most effective at inhibiting alpha-4-beta-2/CHRNA4-CHRNB2 nAChR, followed by VxXXC and VxXXA. VxXII... | |||
TMPH-03352 |
KLKB1 Protein, Rat, Recombinant (His)
Fletcher factor,Klkb1,Plasma prekallikrein,Kininogenin,Plasm... |
Rat | P. pastoris (Yeast) |
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. KLKB1 Protein, Rat, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 29.8 kDa and the accession number is P14272. | |||
TMPH-03351 |
KLKB1 Protein, Rat, Recombinant (E. coli, His)
Plasma prekallikrein,Klkb1,Kininogenin,Plasma kallikrein,Fle... |
Rat | E. coli |
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. KLKB1 Protein, Rat, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.8 kDa and the accession number is P14272. | |||
TMPJ-00734 |
KNG1 Protein, Human, Recombinant (His)
KNG1,High Molecular Weight Kininogen,BDK,HMWK,KNG,Williams-F... |
Human | HEK293 Cells |
Kininogen-1 is a secreted protein which contains three cystatin domains. There are two alternatively spliced forms, designated as the high molecular weight (HMW) and low MW (LMW) forms. Kininogen-1 plays a critical role in blood coagulation and inflammatory response. Kininogens are inhibitors of thiol proteases. Kininogen-1 participates in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII, also inhibits the thrombin- and plasmin-induced aggregation... |